SIMILAR PATTERNS OF AMINO ACIDS FOR 5UOC_B_H4BB502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR

(Trypanosoma
cruzi) 		PF00254
(FKBP_C) 		4 TRP A 123
PHE A 139
VAL A 165
ARG A  95
 None
 1.22A 5uocA-1jvwA:
0.0
5uocB-1jvwA:
0.4		 5uocA-1jvwA:
18.81
5uocB-1jvwA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bih NITRATE REDUCTASE
[NADPH]

(Ogataea angusta) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 TRP A 386
PHE A 328
VAL A 138
ARG A 143
 None
 1.50A 5uocA-2bihA:
0.0
5uocB-2bihA:
0.0		 5uocA-2bihA:
20.55
5uocB-2bihA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans) 		PF14498
(Glyco_hyd_65N_2) 		4 TRP A 630
TRP A 635
PHE A 638
VAL A 588
 None
 1.07A 5uocA-2rdyA:
0.0
5uocB-2rdyA:
0.0		 5uocA-2rdyA:
20.86
5uocB-2rdyA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9t V-TYPE PROTON ATPASE
SUBUNIT H

(Saccharomyces
cerevisiae) 		PF03224
(V-ATPase_H_N)
PF11698
(V-ATPase_H_C) 		4 TRP P 370
TRP P 380
PHE P 379
VAL P 422
 None
 1.42A 5uocA-3j9tP:
0.0
5uocB-3j9tP:
0.0		 5uocA-3j9tP:
20.81
5uocB-3j9tP:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1d UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 4 TRP B 142
VAL B 193
ARG B 150
TRP B  63
 None
 1.47A 5uocA-4r1dB:
0.0
5uocB-4r1dB:
0.0		 5uocA-4r1dB:
22.69
5uocB-4r1dB:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wz9 AGAP004809-PA

(Anopheles
gambiae) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 TRP A 617
PHE A 660
VAL A 599
ARG A 636
 None
 0.93A 5uocA-4wz9A:
0.0
5uocB-4wz9A:
0.0		 5uocA-4wz9A:
19.11
5uocB-4wz9A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jse PHIAB6 TAILSPIKE

(unidentified
phage) 		PF12708
(Pectate_lyase_3) 		4 TRP A 347
PHE A 290
VAL A 341
TRP A 323
 None
 1.13A 5uocA-5jseA:
0.0
5uocB-5jseA:
0.0		 5uocA-5jseA:
18.54
5uocB-5jseA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4c PROLYL
OLIGOPEPTIDASE

(Galerina
marginata) 		no annotation 4 TRP A  97
PHE A 120
ARG A 431
TRP A  95
 None
 1.42A 5uocA-5n4cA:
0.0
5uocB-5n4cA:
0.0		 5uocA-5n4cA:
21.05
5uocB-5n4cA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhe DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA'

(Mycobacterium
tuberculosis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 TRP D 662
PHE D 683
VAL D 635
ARG D 670
 None
 1.50A 5uocA-5uheD:
0.0
5uocB-5uheD:
0.1		 5uocA-5uheD:
15.28
5uocB-5uheD:
15.28