SIMILAR PATTERNS OF AMINO ACIDS FOR 5UO9_D_H4BD502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		4 TRP A 155
PHE A 156
GLU A 154
ARG A 340
 None
 1.36A 5uo9C-1l5jA:
0.0
5uo9D-1l5jA:
0.0		 5uo9C-1l5jA:
20.71
5uo9D-1l5jA:
20.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		4 TRP A 306
TRP A 676
PHE A 691
GLU A 694
 None
 0.20A 5uo9C-1lzxA:
59.2
5uo9D-1lzxA:
51.5		 5uo9C-1lzxA:
61.88
5uo9D-1lzxA:
61.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE

(Homo sapiens) 		PF02898
(NO_synthase) 		4 TRP A  74
TRP A 445
PHE A 460
GLU A 463
 None
MPD  A 603 (-4.6A)
MPD  A 603 (-4.2A)
None
 0.22A 5uo9C-1m9qA:
62.3
5uo9D-1m9qA:
62.7		 5uo9C-1m9qA:
100.00
5uo9D-1m9qA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Mus musculus) 		PF02898
(NO_synthase) 		4 TRP A  84
TRP A 455
PHE A 470
GLU A 473
 None
 0.28A 5uo9C-1qw5A:
56.6
5uo9D-1qw5A:
57.1		 5uo9C-1qw5A:
61.43
5uo9D-1qw5A:
61.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4j SULFATASE MODIFYING
FACTOR 2

(Homo sapiens) 		PF03781
(FGE-sulfatase) 		4 TRP A 169
TRP A 237
GLU A 236
TRP A 235
 None
None
CA  A1004 (-3.6A)
None
 1.17A 5uo9C-1y4jA:
0.0
5uo9D-1y4jA:
undetectable		 5uo9C-1y4jA:
20.69
5uo9D-1y4jA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d52 PENTAKETIDE CHROMONE
SYNTHASE

(Aloe
arborescens) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 PHE A  83
GLU A  87
VAL A  52
ARG A  81
 None
 1.42A 5uo9C-2d52A:
0.7
5uo9D-2d52A:
1.0		 5uo9C-2d52A:
20.39
5uo9D-2d52A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi8 SULFATASE-MODIFYING
FACTOR 1

(Homo sapiens) 		PF03781
(FGE-sulfatase) 		4 TRP X 231
TRP X 301
GLU X 300
TRP X 299
 None
None
CA  X1016 (-3.3A)
BR  X1001 ( 4.4A)
 1.27A 5uo9C-2hi8X:
undetectable
5uo9D-2hi8X:
0.0		 5uo9C-2hi8X:
21.09
5uo9D-2hi8X:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9u CYTOSINE/GUANINE
DEAMINASE RELATED
PROTEIN

(Clostridium
acetobutylicum) 		PF01979
(Amidohydro_1) 		4 PHE A  99
GLU A 101
ARG A 202
TRP A  93
 None
None
GUN  A 503 (-3.7A)
None
 1.34A 5uo9C-2i9uA:
0.0
5uo9D-2i9uA:
0.0		 5uo9C-2i9uA:
20.20
5uo9D-2i9uA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS) 		4 PHE A  29
GLU A  27
VAL A  23
ARG A 116
 None
 1.17A 5uo9C-2incA:
0.0
5uo9D-2incA:
0.0		 5uo9C-2incA:
21.77
5uo9D-2incA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans) 		PF14498
(Glyco_hyd_65N_2) 		4 TRP A 630
TRP A 635
PHE A 638
VAL A 588
 None
 1.12A 5uo9C-2rdyA:
undetectable
5uo9D-2rdyA:
0.0		 5uo9C-2rdyA:
20.86
5uo9D-2rdyA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rtt CHIC

(Streptomyces
coelicolor) 		PF00553
(CBM_2) 		4 PHE A  41
GLU A  38
VAL A  37
TRP A  22
 None
 1.34A 5uo9C-2rttA:
undetectable
5uo9D-2rttA:
undetectable		 5uo9C-2rttA:
15.38
5uo9D-2rttA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqx ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D

(Streptococcus
pneumoniae) 		PF00754
(F5_F8_type_C) 		4 TRP A 840
PHE A 816
GLU A 826
VAL A 811
 None
 1.47A 5uo9C-2xqxA:
undetectable
5uo9D-2xqxA:
undetectable		 5uo9C-2xqxA:
14.58
5uo9D-2xqxA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yd3 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S

(Homo sapiens) 		PF07679
(I-set) 		4 PHE A  78
GLU A 102
VAL A 124
ARG A  77
 None
 1.49A 5uo9C-2yd3A:
undetectable
5uo9D-2yd3A:
undetectable		 5uo9C-2yd3A:
19.36
5uo9D-2yd3A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2f DNA POLYMERASE

(Pyrococcus
furiosus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 TRP A 526
PHE A 564
GLU A 530
VAL A 537
 None
 1.42A 5uo9C-3a2fA:
0.0
5uo9D-3a2fA:
0.0		 5uo9C-3a2fA:
19.51
5uo9D-3a2fA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwv PUTATIVE
5'(3')-DEOXYRIBONUCL
EOTIDASE

(Staphylococcus
epidermidis) 		PF06941
(NT5C) 		4 PHE A 110
GLU A  75
VAL A  76
TRP A 167
 None
 1.47A 5uo9C-3bwvA:
undetectable
5uo9D-3bwvA:
undetectable		 5uo9C-3bwvA:
17.52
5uo9D-3bwvA:
17.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		4 TRP A  90
TRP A 461
PHE A 476
GLU A 479
 None
 0.22A 5uo9C-3e7gA:
55.0
5uo9D-3e7gA:
55.6		 5uo9C-3e7gA:
58.24
5uo9D-3e7gA:
58.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 TRP A 248
PHE A 243
GLU A 245
ARG A 260
 None
 1.31A 5uo9C-3f3zA:
undetectable
5uo9D-3f3zA:
undetectable		 5uo9C-3f3zA:
21.22
5uo9D-3f3zA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1

(Homo sapiens) 		PF00632
(HECT) 		4 PHE A4109
GLU A4033
VAL A4019
TRP A4065
 None
 1.26A 5uo9C-3g1nA:
undetectable
5uo9D-3g1nA:
undetectable		 5uo9C-3g1nA:
21.02
5uo9D-3g1nA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k25 SLR1438 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF01263
(Aldose_epim) 		4 TRP A 256
PHE A 233
GLU A 254
VAL A 241
 None
 0.97A 5uo9C-3k25A:
undetectable
5uo9D-3k25A:
undetectable		 5uo9C-3k25A:
20.67
5uo9D-3k25A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcc PUTATIVE METHYL
CHLORIDE TRANSFERASE

(Arabidopsis
thaliana) 		PF05724
(TPMT) 		4 PHE A 133
GLU A 122
VAL A 120
ARG A  69
 None
 1.28A 5uo9C-3lccA:
undetectable
5uo9D-3lccA:
undetectable		 5uo9C-3lccA:
17.98
5uo9D-3lccA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcs VERSATILE PEROXIDASE
VPL2

(Pleurotus
eryngii) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 TRP A 164
TRP A 244
GLU A 243
VAL A 160
 None
 1.37A 5uo9C-4fcsA:
undetectable
5uo9D-4fcsA:
undetectable		 5uo9C-4fcsA:
20.35
5uo9D-4fcsA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3q CATECHOL OXIDASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		4 TRP A  58
TRP A 143
PHE A 158
ARG A 239
 None
 1.28A 5uo9C-4j3qA:
undetectable
5uo9D-4j3qA:
undetectable		 5uo9C-4j3qA:
21.05
5uo9D-4j3qA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nk2 HEMOGLOBIN-LIKE
PROTEIN

(Methylacidiphilum
infernorum) 		PF01152
(Bac_globin) 		4 PHE A 191
GLU A 186
VAL A 182
TRP A 159
 None
 1.00A 5uo9C-4nk2A:
undetectable
5uo9D-4nk2A:
undetectable		 5uo9C-4nk2A:
18.22
5uo9D-4nk2A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6x ANKYRIN-3

(Homo sapiens) 		PF00531
(Death) 		4 PHE A  28
GLU A  25
VAL A  71
ARG A  58
 None
 1.15A 5uo9C-4o6xA:
undetectable
5uo9D-4o6xA:
undetectable		 5uo9C-4o6xA:
12.95
5uo9D-4o6xA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qbu ZMAA

(Bacillus cereus) 		PF00698
(Acyl_transf_1) 		4 TRP A 428
PHE A 431
GLU A 429
ARG A   9
 None
 1.42A 5uo9C-4qbuA:
undetectable
5uo9D-4qbuA:
undetectable		 5uo9C-4qbuA:
21.46
5uo9D-4qbuA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3v POLYKETIDE SYNTHASE
PKSR

(Bacillus
subtilis) 		PF14765
(PS-DH) 		4 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.05A 5uo9C-4u3vA:
0.0
5uo9D-4u3vA:
undetectable		 5uo9C-4u3vA:
20.76
5uo9D-4u3vA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cow PUTATIVE
UNCHARACTERIZED
PROTEIN

(Caenorhabditis
remanei) 		no annotation 4 TRP A 407
PHE A 404
GLU A 410
VAL A 409
 None
 1.31A 5uo9C-5cowA:
undetectable
5uo9D-5cowA:
undetectable		 5uo9C-5cowA:
21.97
5uo9D-5cowA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ft6 CYSTEINE DESULFURASE
CSDA

(Escherichia
coli) 		PF00266
(Aminotran_5) 		4 TRP A 288
PHE A  13
GLU A  33
VAL A  36
 None
 1.50A 5uo9C-5ft6A:
0.5
5uo9D-5ft6A:
undetectable		 5uo9C-5ft6A:
22.63
5uo9D-5ft6A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gn5 GLYCEROL KINASE

(Trypanosoma
brucei) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.40A 5uo9C-5gn5A:
undetectable
5uo9D-5gn5A:
0.0		 5uo9C-5gn5A:
21.73
5uo9D-5gn5A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hh9 PVDN

(Pseudomonas
aeruginosa) 		PF00266
(Aminotran_5) 		4 PHE A 367
GLU A 246
VAL A 245
TRP A 265
 None
 1.44A 5uo9C-5hh9A:
undetectable
5uo9D-5hh9A:
undetectable		 5uo9C-5hh9A:
21.59
5uo9D-5hh9A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jse PHIAB6 TAILSPIKE

(unidentified
phage) 		PF12708
(Pectate_lyase_3) 		4 TRP A 347
PHE A 290
VAL A 341
TRP A 323
 None
 1.06A 5uo9C-5jseA:
undetectable
5uo9D-5jseA:
undetectable		 5uo9C-5jseA:
18.54
5uo9D-5jseA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1h EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B

(Homo sapiens) 		PF00076
(RRM_1)
PF08662
(eIF2A) 		4 TRP B 607
TRP B 562
GLU B 561
VAL B 570
 None
 1.35A 5uo9C-5k1hB:
undetectable
5uo9D-5k1hB:
undetectable		 5uo9C-5k1hB:
20.00
5uo9D-5k1hB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		4 TRP A 251
GLU A 254
VAL A 329
TRP A 324
 FAD  A 901 (-3.9A)
None
None
None
 1.42A 5uo9C-5l46A:
undetectable
5uo9D-5l46A:
undetectable		 5uo9C-5l46A:
18.71
5uo9D-5l46A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1

(Homo sapiens) 		no annotation 4 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.19A 5uo9C-5lp8B:
undetectable
5uo9D-5lp8B:
undetectable		 5uo9C-5lp8B:
22.42
5uo9D-5lp8B:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m7r PROTEIN O-GLCNACASE

(Homo sapiens) 		PF07555
(NAGidase) 		4 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.39A 5uo9C-5m7rA:
undetectable
5uo9D-5m7rA:
0.0		 5uo9C-5m7rA:
19.59
5uo9D-5m7rA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		4 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.05A 5uo9C-5m8tA:
undetectable
5uo9D-5m8tA:
undetectable		 5uo9C-5m8tA:
22.16
5uo9D-5m8tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no8 BACCELL_00875

(Bacteroides
cellulosilyticus) 		no annotation 4 TRP A 599
PHE A 606
VAL A 538
ARG A 205
 None
 1.39A 5uo9C-5no8A:
0.0
5uo9D-5no8A:
0.2		 5uo9C-5no8A:
21.46
5uo9D-5no8A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE

(Thermomonospora
curvata) 		PF03781
(FGE-sulfatase) 		4 TRP A 160
TRP A 230
GLU A 229
TRP A 228
 None
None
CA  A 407 (-3.9A)
ACT  A 405 (-3.9A)
 1.16A 5uo9C-5nyyA:
undetectable
5uo9D-5nyyA:
undetectable		 5uo9C-5nyyA:
20.76
5uo9D-5nyyA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhp O-GLCNACASE
TIM-BARREL DOMAIN

(Homo sapiens) 		PF07555
(NAGidase) 		4 TRP A  73
PHE A 318
GLU A 317
ARG A  84
 None
 1.50A 5uo9C-5uhpA:
undetectable
5uo9D-5uhpA:
undetectable		 5uo9C-5uhpA:
23.16
5uo9D-5uhpA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyo THIOL:DISULFIDE
INTERCHANGE PROTEIN

(Burkholderia
pseudomallei) 		no annotation 4 PHE A  49
GLU A  54
VAL A  57
TRP A  56
 None
 1.07A 5uo9C-5vyoA:
undetectable
5uo9D-5vyoA:
undetectable		 5uo9C-5vyoA:
12.05
5uo9D-5vyoA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gk6 -

(-) 		no annotation 4 TRP A  45
TRP A 297
GLU A 313
VAL A 309
 None
 1.30A 5uo9C-6gk6A:
0.0
5uo9D-6gk6A:
undetectable		 5uo9C-6gk6A:
undetectable
5uo9D-6gk6A:
undetectable