SIMILAR PATTERNS OF AMINO ACIDS FOR 5UO9_B_H4BB502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dvk PRP18

(Saccharomyces
cerevisiae) 		PF02840
(Prp18) 		4 TRP A 242
PHE A 239
GLU A 241
ARG A 123
 None
 1.43A 5uo9A-1dvkA:
0.0
5uo9B-1dvkA:
0.1		 5uo9A-1dvkA:
16.48
5uo9B-1dvkA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kex NEUROPILIN-1

(Homo sapiens) 		PF00754
(F5_F8_type_C) 		4 TRP A  97
PHE A 131
GLU A  95
ARG A 130
 None
 1.50A 5uo9A-1kexA:
0.0
5uo9B-1kexA:
0.0		 5uo9A-1kexA:
16.39
5uo9B-1kexA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		4 TRP A 155
PHE A 156
GLU A 154
ARG A 340
 None
 1.30A 5uo9A-1l5jA:
0.0
5uo9B-1l5jA:
0.0		 5uo9A-1l5jA:
20.71
5uo9B-1l5jA:
20.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		4 TRP A 306
TRP A 676
PHE A 691
GLU A 694
 None
 0.28A 5uo9A-1lzxA:
58.3
5uo9B-1lzxA:
59.4		 5uo9A-1lzxA:
61.88
5uo9B-1lzxA:
61.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE

(Homo sapiens) 		PF02898
(NO_synthase) 		4 TRP A  74
TRP A 445
PHE A 460
GLU A 463
 None
MPD  A 603 (-4.6A)
MPD  A 603 (-4.2A)
None
 0.25A 5uo9A-1m9qA:
61.0
5uo9B-1m9qA:
63.0		 5uo9A-1m9qA:
100.00
5uo9B-1m9qA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Mus musculus) 		PF02898
(NO_synthase) 		4 TRP A  84
TRP A 455
PHE A 470
GLU A 473
 None
 0.34A 5uo9A-1qw5A:
43.3
5uo9B-1qw5A:
56.7		 5uo9A-1qw5A:
61.43
5uo9B-1qw5A:
61.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4j SULFATASE MODIFYING
FACTOR 2

(Homo sapiens) 		PF03781
(FGE-sulfatase) 		4 TRP A 169
TRP A 237
GLU A 236
TRP A 235
 None
None
CA  A1004 (-3.6A)
None
 1.18A 5uo9A-1y4jA:
0.0
5uo9B-1y4jA:
0.0		 5uo9A-1y4jA:
20.69
5uo9B-1y4jA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d52 PENTAKETIDE CHROMONE
SYNTHASE

(Aloe
arborescens) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 PHE A  83
GLU A  87
VAL A  52
ARG A  81
 None
 1.38A 5uo9A-2d52A:
0.9
5uo9B-2d52A:
0.9		 5uo9A-2d52A:
20.39
5uo9B-2d52A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9j REGULATOR OF
G-PROTEIN SIGNALLING
7

(Homo sapiens) 		PF00615
(RGS) 		4 PHE A 123
GLU A  30
VAL A  27
TRP A  15
 None
 1.35A 5uo9A-2d9jA:
0.0
5uo9B-2d9jA:
0.0		 5uo9A-2d9jA:
17.36
5uo9B-2d9jA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi8 SULFATASE-MODIFYING
FACTOR 1

(Homo sapiens) 		PF03781
(FGE-sulfatase) 		4 TRP X 231
TRP X 301
GLU X 300
TRP X 299
 None
None
CA  X1016 (-3.3A)
BR  X1001 ( 4.4A)
 1.31A 5uo9A-2hi8X:
undetectable
5uo9B-2hi8X:
undetectable		 5uo9A-2hi8X:
21.09
5uo9B-2hi8X:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS) 		4 PHE A  29
GLU A  27
VAL A  23
ARG A 116
 None
 1.29A 5uo9A-2incA:
undetectable
5uo9B-2incA:
undetectable		 5uo9A-2incA:
21.77
5uo9B-2incA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans) 		PF14498
(Glyco_hyd_65N_2) 		4 TRP A 630
TRP A 635
PHE A 638
VAL A 588
 None
 1.14A 5uo9A-2rdyA:
undetectable
5uo9B-2rdyA:
0.0		 5uo9A-2rdyA:
20.86
5uo9B-2rdyA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rtt CHIC

(Streptomyces
coelicolor) 		PF00553
(CBM_2) 		4 PHE A  41
GLU A  38
VAL A  37
TRP A  22
 None
 1.44A 5uo9A-2rttA:
undetectable
5uo9B-2rttA:
undetectable		 5uo9A-2rttA:
15.38
5uo9B-2rttA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1

(Schizosaccharomyces
pombe) 		PF10471
(ANAPC_CDC26)
PF12895
(ANAPC3)
PF13181
(TPR_8)
PF13424
(TPR_12) 		4 PHE A 321
VAL A 505
ARG B   4
TRP A 515
 None
 1.49A 5uo9A-2xpiA:
undetectable
5uo9B-2xpiA:
0.0		 5uo9A-2xpiA:
20.66
5uo9B-2xpiA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2f DNA POLYMERASE

(Pyrococcus
furiosus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 TRP A 526
PHE A 564
GLU A 530
VAL A 537
 None
 1.37A 5uo9A-3a2fA:
undetectable
5uo9B-3a2fA:
undetectable		 5uo9A-3a2fA:
19.51
5uo9B-3a2fA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckb SUSD

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB) 		4 TRP A 485
PHE A 489
GLU A 484
ARG A 437
 None
 0.94A 5uo9A-3ckbA:
undetectable
5uo9B-3ckbA:
0.0		 5uo9A-3ckbA:
20.99
5uo9B-3ckbA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4e PUTATIVE
BETA-LACTAMASE
INHIBITOR PROTEIN

(Streptococcus
mutans) 		PF12978
(DUF3862) 		4 TRP A 175
PHE A 127
VAL A 151
ARG A  52
 None
 1.24A 5uo9A-3d4eA:
undetectable
5uo9B-3d4eA:
undetectable		 5uo9A-3d4eA:
16.06
5uo9B-3d4eA:
16.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		4 TRP A  90
TRP A 461
PHE A 476
GLU A 479
 None
 0.26A 5uo9A-3e7gA:
54.5
5uo9B-3e7gA:
55.3		 5uo9A-3e7gA:
58.24
5uo9B-3e7gA:
58.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k25 SLR1438 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF01263
(Aldose_epim) 		4 TRP A 256
PHE A 233
GLU A 254
VAL A 241
 None
 0.93A 5uo9A-3k25A:
undetectable
5uo9B-3k25A:
undetectable		 5uo9A-3k25A:
20.67
5uo9B-3k25A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k77 DNA REPAIR PROTEIN
XRCC1

(Homo sapiens) 		PF01834
(XRCC1_N) 		4 PHE A  93
GLU A  69
VAL A  89
ARG A 109
 None
 1.43A 5uo9A-3k77A:
undetectable
5uo9B-3k77A:
undetectable		 5uo9A-3k77A:
15.58
5uo9B-3k77A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcc PUTATIVE METHYL
CHLORIDE TRANSFERASE

(Arabidopsis
thaliana) 		PF05724
(TPMT) 		4 PHE A 133
GLU A 122
VAL A 120
ARG A  69
 None
 1.33A 5uo9A-3lccA:
undetectable
5uo9B-3lccA:
undetectable		 5uo9A-3lccA:
17.98
5uo9B-3lccA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv4 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN

(Thermosynechococcus
elongatus) 		PF01590
(GAF) 		4 PHE A  67
GLU A  73
VAL A  72
TRP A  71
 None
None
None
PVG  A 201 (-3.6A)
 1.09A 5uo9A-3vv4A:
undetectable
5uo9B-3vv4A:
undetectable		 5uo9A-3vv4A:
18.33
5uo9B-3vv4A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zn6 VP17

(Thermus virus
P23-77) 		no annotation 4 PHE A 166
GLU A 179
VAL A 102
ARG A 114
 None
 1.33A 5uo9A-3zn6A:
undetectable
5uo9B-3zn6A:
undetectable		 5uo9A-3zn6A:
20.18
5uo9B-3zn6A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcs VERSATILE PEROXIDASE
VPL2

(Pleurotus
eryngii) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 TRP A 164
TRP A 244
GLU A 243
VAL A 160
 None
 1.29A 5uo9A-4fcsA:
undetectable
5uo9B-4fcsA:
undetectable		 5uo9A-4fcsA:
20.35
5uo9B-4fcsA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6x ANKYRIN-3

(Homo sapiens) 		PF00531
(Death) 		4 PHE A  28
GLU A  25
VAL A  71
ARG A  58
 None
 1.20A 5uo9A-4o6xA:
undetectable
5uo9B-4o6xA:
undetectable		 5uo9A-4o6xA:
12.95
5uo9B-4o6xA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3v POLYKETIDE SYNTHASE
PKSR

(Bacillus
subtilis) 		PF14765
(PS-DH) 		4 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.09A 5uo9A-4u3vA:
undetectable
5uo9B-4u3vA:
undetectable		 5uo9A-4u3vA:
20.76
5uo9B-4u3vA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8d SULFOXIDE SYNTHASE
EGTB

(Mycolicibacterium
thermoresistibile) 		PF03781
(FGE-sulfatase)
PF12867
(DinB_2) 		4 TRP A 299
TRP A 361
GLU A 360
TRP A 359
 None
None
CA  A 517 (-3.9A)
None
 1.19A 5uo9A-4x8dA:
0.0
5uo9B-4x8dA:
0.0		 5uo9A-4x8dA:
22.77
5uo9B-4x8dA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cow PUTATIVE
UNCHARACTERIZED
PROTEIN

(Caenorhabditis
remanei) 		no annotation 4 TRP A 407
PHE A 404
GLU A 410
VAL A 409
 None
 1.34A 5uo9A-5cowA:
undetectable
5uo9B-5cowA:
undetectable		 5uo9A-5cowA:
21.97
5uo9B-5cowA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ft6 CYSTEINE DESULFURASE
CSDA

(Escherichia
coli) 		PF00266
(Aminotran_5) 		4 TRP A 288
PHE A  13
GLU A  33
VAL A  36
 None
 1.45A 5uo9A-5ft6A:
undetectable
5uo9B-5ft6A:
undetectable		 5uo9A-5ft6A:
22.63
5uo9B-5ft6A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gn5 GLYCEROL KINASE

(Trypanosoma
brucei) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.50A 5uo9A-5gn5A:
undetectable
5uo9B-5gn5A:
undetectable		 5uo9A-5gn5A:
21.73
5uo9B-5gn5A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jse PHIAB6 TAILSPIKE

(unidentified
phage) 		PF12708
(Pectate_lyase_3) 		4 TRP A 347
PHE A 290
VAL A 341
TRP A 323
 None
 1.09A 5uo9A-5jseA:
undetectable
5uo9B-5jseA:
undetectable		 5uo9A-5jseA:
18.54
5uo9B-5jseA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1h EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B

(Homo sapiens) 		PF00076
(RRM_1)
PF08662
(eIF2A) 		4 TRP B 607
TRP B 562
GLU B 561
VAL B 570
 None
 1.38A 5uo9A-5k1hB:
undetectable
5uo9B-5k1hB:
undetectable		 5uo9A-5k1hB:
20.00
5uo9B-5k1hB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		4 TRP A 251
GLU A 254
VAL A 329
TRP A 324
 FAD  A 901 (-3.9A)
None
None
None
 1.49A 5uo9A-5l46A:
0.0
5uo9B-5l46A:
undetectable		 5uo9A-5l46A:
18.71
5uo9B-5l46A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1

(Homo sapiens) 		no annotation 4 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.23A 5uo9A-5lp8B:
undetectable
5uo9B-5lp8B:
undetectable		 5uo9A-5lp8B:
22.42
5uo9B-5lp8B:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG

(Homo sapiens) 		PF08641
(Mis14)
PF15622
(CENP_C_N) 		4 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.12A 5uo9A-5lskN:
undetectable
5uo9B-5lskN:
undetectable		 5uo9A-5lskN:
20.23
5uo9B-5lskN:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		4 TRP A 414
PHE A 411
GLU A 413
ARG A 225
 None
 1.06A 5uo9A-5m8tA:
0.0
5uo9B-5m8tA:
undetectable		 5uo9A-5m8tA:
22.16
5uo9B-5m8tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE

(Thermomonospora
curvata) 		PF03781
(FGE-sulfatase) 		4 TRP A 160
TRP A 230
GLU A 229
TRP A 228
 None
None
CA  A 407 (-3.9A)
ACT  A 405 (-3.9A)
 1.19A 5uo9A-5nyyA:
undetectable
5uo9B-5nyyA:
undetectable		 5uo9A-5nyyA:
20.76
5uo9B-5nyyA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyo THIOL:DISULFIDE
INTERCHANGE PROTEIN

(Burkholderia
pseudomallei) 		no annotation 4 PHE A  49
GLU A  54
VAL A  57
TRP A  56
 None
 0.98A 5uo9A-5vyoA:
0.0
5uo9B-5vyoA:
undetectable		 5uo9A-5vyoA:
12.05
5uo9B-5vyoA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S5-B,
PUTATIVE
UNCHARACTERIZED
PROTEIN

(Trichomonas
vaginalis) 		PF00177
(Ribosomal_S7)
PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C) 		4 PHE F  50
GLU c  51
VAL c  16
ARG F  49
 None
None
None
C  21421 ( 4.4A)
 0.98A 5uo9A-5xyiF:
undetectable
5uo9B-5xyiF:
undetectable		 5uo9A-5xyiF:
18.69
5uo9B-5xyiF:
18.69