SIMILAR PATTERNS OF AMINO ACIDS FOR 5UO8_A_H4BA502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a88 CHLOROPEROXIDASE L

(Streptomyces
lividans) 		PF00561
(Abhydrolase_1) 		4 SER A 203
ARG A 104
PHE A 207
GLU A 204
 None
 1.34A 5uo8A-1a88A:
0.0
5uo8B-1a88A:
0.0		 5uo8A-1a88A:
20.78
5uo8B-1a88A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a8s CHLOROPEROXIDASE F

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		4 SER A 201
ARG A 102
PHE A 205
GLU A 202
 None
 1.39A 5uo8A-1a8sA:
0.0
5uo8B-1a8sA:
0.0		 5uo8A-1a8sA:
21.43
5uo8B-1a8sA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b2h PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Salmonella
enterica) 		PF00496
(SBP_bac_5) 		4 SER A  21
TRP A 397
PHE A 400
GLU A 396
 None
ACT  A 518 ( 4.2A)
None
None
 1.46A 5uo8A-1b2hA:
0.0
5uo8B-1b2hA:
0.0		 5uo8A-1b2hA:
21.88
5uo8B-1b2hA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j85 YIBK

(Haemophilus
influenzae) 		PF00588
(SpoU_methylase) 		4 SER A  87
ARG A  74
PHE A  76
GLU A 143
 None
 1.39A 5uo8A-1j85A:
0.0
5uo8B-1j85A:
0.0		 5uo8A-1j85A:
15.23
5uo8B-1j85A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k38 BETA-LACTAMASE OXA-2

(Salmonella
enterica) 		PF00905
(Transpeptidase) 		4 SER A  64
ARG A  58
TRP A 214
GLU A 209
 None
 1.22A 5uo8A-1k38A:
0.1
5uo8B-1k38A:
0.3		 5uo8A-1k38A:
20.75
5uo8B-1k38A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kex NEUROPILIN-1

(Homo sapiens) 		PF00754
(F5_F8_type_C) 		4 ARG A 130
TRP A  97
PHE A 131
GLU A  95
 None
 1.48A 5uo8A-1kexA:
0.0
5uo8B-1kexA:
0.0		 5uo8A-1kexA:
16.39
5uo8B-1kexA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfu M-CALPAIN LARGE
SUBUNIT

(Homo sapiens) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		4 SER L 236
ARG L 500
PHE L 502
GLU L 339
 None
 1.04A 5uo8A-1kfuL:
0.0
5uo8B-1kfuL:
0.0		 5uo8A-1kfuL:
21.13
5uo8B-1kfuL:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		4 ARG A 340
TRP A 155
PHE A 156
GLU A 154
 None
 1.35A 5uo8A-1l5jA:
0.0
5uo8B-1l5jA:
0.0		 5uo8A-1l5jA:
20.71
5uo8B-1l5jA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxp MU-LIKE CALPAIN

(Bos taurus;
Rattus
norvegicus) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		4 SER A 236
ARG A 501
PHE A 503
GLU A 339
 None
 1.45A 5uo8A-1qxpA:
0.0
5uo8B-1qxpA:
0.0		 5uo8A-1qxpA:
20.13
5uo8B-1qxpA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9f ARGININOSUCCINATE
LYASE

(Thermus
thermophilus) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		4 ARG A 123
TRP A  37
PHE A 221
GLU A 218
 None
 1.37A 5uo8A-2e9fA:
undetectable
5uo8B-2e9fA:
0.0		 5uo8A-2e9fA:
22.12
5uo8B-2e9fA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqo NEUROPILIN-2

(Homo sapiens) 		PF00431
(CUB)
PF00754
(F5_F8_type_C) 		4 ARG A 405
TRP A 372
PHE A 406
GLU A 370
 None
 1.49A 5uo8A-2qqoA:
undetectable
5uo8B-2qqoA:
undetectable		 5uo8A-2qqoA:
22.95
5uo8B-2qqoA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		4 SER A  21
TRP A 397
PHE A 400
GLU A 396
 None
 1.40A 5uo8A-2z23A:
0.0
5uo8B-2z23A:
0.0		 5uo8A-2z23A:
20.97
5uo8B-2z23A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckb SUSD

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB) 		4 ARG A 437
TRP A 485
PHE A 489
GLU A 484
 None
 1.01A 5uo8A-3ckbA:
0.0
5uo8B-3ckbA:
0.0		 5uo8A-3ckbA:
20.99
5uo8B-3ckbA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Enterococcus
faecalis) 		PF13377
(Peripla_BP_3) 		4 SER A 266
ARG A 187
PHE A 263
GLU A 238
 None
GOL  A 401 (-2.6A)
None
GOL  A 401 ( 4.9A)
 1.48A 5uo8A-3cs3A:
undetectable
5uo8B-3cs3A:
undetectable		 5uo8A-3cs3A:
20.40
5uo8B-3cs3A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hri HISTIDYL-TRNA
SYNTHETASE

(Trypanosoma
brucei) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 SER A 149
TRP A 170
PHE A  83
GLU A  85
 None
 1.47A 5uo8A-3hriA:
undetectable
5uo8B-3hriA:
undetectable		 5uo8A-3hriA:
22.48
5uo8B-3hriA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if6 OXA-46 OXACILLINASE

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase) 		4 SER C  69
ARG C  63
TRP C 219
GLU C 214
 None
 1.12A 5uo8A-3if6C:
undetectable
5uo8B-3if6C:
undetectable		 5uo8A-3if6C:
19.77
5uo8B-3if6C:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kve L-AMINO ACID OXIDASE

(Vipera
ammodytes) 		PF01593
(Amino_oxidase) 		4 SER A 468
ARG A 478
PHE A  19
GLU A 461
 None
 1.44A 5uo8A-3kveA:
undetectable
5uo8B-3kveA:
undetectable		 5uo8A-3kveA:
20.35
5uo8B-3kveA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0g ISOPRENE SYNTHASE

(Populus tremula
x Populus alba) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 SER A 171
ARG A 159
PHE A 155
GLU A 168
 None
 1.19A 5uo8A-3n0gA:
0.0
5uo8B-3n0gA:
undetectable		 5uo8A-3n0gA:
21.35
5uo8B-3n0gA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0q PUTATIVE
AROMATIC-RING
HYDROXYLATING
DIOXYGENASE

(Ruegeria sp.
TM1040) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 SER A 394
TRP A 391
PHE A 388
GLU A 390
 None
None
None
GOL  A 507 (-2.5A)
 1.10A 5uo8A-3n0qA:
undetectable
5uo8B-3n0qA:
undetectable		 5uo8A-3n0qA:
22.18
5uo8B-3n0qA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0s HYGROMYCIN-B
4-O-KINASE

(Escherichia
coli) 		PF01636
(APH) 		4 SER A 218
TRP A 217
PHE A 136
GLU A 219
 HY0  A 401 (-3.5A)
None
None
HY0  A 401 (-4.0A)
 1.16A 5uo8A-3w0sA:
undetectable
5uo8B-3w0sA:
undetectable		 5uo8A-3w0sA:
22.49
5uo8B-3w0sA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A

(Saccharomyces
cerevisiae) 		PF16787
(NDC10_II) 		4 SER A 232
ARG A 355
PHE A 359
GLU A 229
 None
 1.38A 5uo8A-4acoA:
undetectable
5uo8B-4acoA:
0.0		 5uo8A-4acoA:
17.69
5uo8B-4acoA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eei ADENYLOSUCCINATE
LYASE

(Francisella
tularensis) 		PF00206
(Lyase_1) 		4 SER A  75
ARG A  50
PHE A  80
GLU A  78
 None
 1.40A 5uo8A-4eeiA:
undetectable
5uo8B-4eeiA:
undetectable		 5uo8A-4eeiA:
19.18
5uo8B-4eeiA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fm9 DNA TOPOISOMERASE
2-ALPHA

(Homo sapiens) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		4 SER A 601
TRP A 598
PHE A 595
GLU A 597
 None
 1.48A 5uo8A-4fm9A:
undetectable
5uo8B-4fm9A:
undetectable		 5uo8A-4fm9A:
21.14
5uo8B-4fm9A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas sp.
WBC-3) 		PF00171
(Aldedh) 		4 SER A 174
ARG A 331
TRP A 148
GLU A 175
 NAD  A 601 (-3.8A)
None
NAD  A 601 (-4.0A)
NAD  A 601 (-3.7A)
 1.50A 5uo8A-4go4A:
undetectable
5uo8B-4go4A:
undetectable		 5uo8A-4go4A:
20.38
5uo8B-4go4A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gym GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Conexibacter
woesei) 		no annotation 4 SER A 116
TRP A 125
PHE A  91
GLU A 126
 None
 1.22A 5uo8A-4gymA:
undetectable
5uo8B-4gymA:
undetectable		 5uo8A-4gymA:
16.44
5uo8B-4gymA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kdz TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Escherichia
coli) 		PF00588
(SpoU_methylase) 		4 SER A  87
ARG A  74
PHE A  76
GLU A 143
 None
 1.28A 5uo8A-4kdzA:
undetectable
5uo8B-4kdzA:
undetectable		 5uo8A-4kdzA:
14.77
5uo8B-4kdzA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oro POLYMERASE PB2

(Influenza B
virus) 		PF00604
(Flu_PB2) 		4 SER A 407
ARG A 334
TRP A 359
PHE A 365
 None
GDP  A 501 (-4.1A)
GDP  A 501 (-3.3A)
None
 1.22A 5uo8A-4oroA:
undetectable
5uo8B-4oroA:
undetectable		 5uo8A-4oroA:
19.89
5uo8B-4oroA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN

(Nitratireductor
pacificus) 		PF12838
(Fer4_7)
PF13486
(Dehalogenase) 		4 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.49A 5uo8A-4rasA:
undetectable
5uo8B-4rasA:
0.0		 5uo8A-4rasA:
20.90
5uo8B-4rasA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tq5 PRENYLTRANSFERASE

(Archaeoglobus
fulgidus) 		PF01040
(UbiA) 		4 SER A  64
TRP A  26
TRP A  60
PHE A  57
 None
 1.41A 5uo8A-4tq5A:
undetectable
5uo8B-4tq5A:
undetectable		 5uo8A-4tq5A:
20.85
5uo8B-4tq5A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bv9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Bacillus
pumilus) 		PF02011
(Glyco_hydro_48) 		4 ARG A 644
TRP A 185
PHE A 640
GLU A 186
 None
None
None
CA  A 801 (-2.3A)
 1.28A 5uo8A-5bv9A:
undetectable
5uo8B-5bv9A:
undetectable		 5uo8A-5bv9A:
21.23
5uo8B-5bv9A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fip GH5 CELLULASE

(unidentified) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		4 SER A 266
TRP A 314
PHE A 317
GLU A 313
 IPA  A1395 (-4.8A)
None
PEG  A1387 (-4.7A)
None
 1.50A 5uo8A-5fipA:
undetectable
5uo8B-5fipA:
undetectable		 5uo8A-5fipA:
23.44
5uo8B-5fipA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iwz SYNAPTONEMAL COMPLEX
PROTEIN 2

(Mus musculus) 		no annotation 4 SER A 201
TRP A 239
PHE A 249
GLU A 205
 None
 1.17A 5uo8A-5iwzA:
undetectable
5uo8B-5iwzA:
undetectable		 5uo8A-5iwzA:
20.69
5uo8B-5iwzA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		4 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.03A 5uo8A-5m8tA:
undetectable
5uo8B-5m8tA:
undetectable		 5uo8A-5m8tA:
22.16
5uo8B-5m8tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE

(Archaeoglobus
fulgidus) 		no annotation 4 SER A 278
ARG A  44
PHE A  43
GLU A 282
 None
 1.39A 5uo8A-5mqzA:
undetectable
5uo8B-5mqzA:
undetectable		 5uo8A-5mqzA:
12.96
5uo8B-5mqzA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 4 SER W 523
ARG W 537
PHE W 558
GLU W 527
 None
 1.45A 5uo8A-5o9gW:
undetectable
5uo8B-5o9gW:
undetectable		 5uo8A-5o9gW:
13.99
5uo8B-5o9gW:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tul TETRACYCLINE
DESTRUCTASE TET(55)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		4 SER A 350
TRP A 346
PHE A 343
GLU A 349
 None
 1.26A 5uo8A-5tulA:
0.0
5uo8B-5tulA:
undetectable		 5uo8A-5tulA:
23.01
5uo8B-5tulA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uv2 (+)-LIMONENE
SYNTHASE

(Citrus sinensis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 SER A 168
ARG A 156
PHE A 152
GLU A 165
 None
 1.25A 5uo8A-5uv2A:
0.0
5uo8B-5uv2A:
undetectable		 5uo8A-5uv2A:
21.51
5uo8B-5uv2A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE

(Escherichia
coli) 		no annotation 4 SER A 224
ARG A  24
TRP A 219
GLU A 222
 None
 1.09A 5uo8A-5wlyA:
undetectable
5uo8B-5wlyA:
undetectable		 5uo8A-5wlyA:
10.83
5uo8B-5wlyA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o POLYMERASE BASIC
PROTEIN 2

(Influenza B
virus) 		no annotation 4 SER C 407
ARG C 334
TRP C 359
PHE C 365
 None
 1.47A 5uo8A-6f5oC:
0.0
5uo8B-6f5oC:
undetectable		 5uo8A-6f5oC:
11.50
5uo8B-6f5oC:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gsa -

(-) 		no annotation 4 SER E 232
ARG E 355
PHE E 359
GLU E 229
 None
 1.38A 5uo8A-6gsaE:
0.0
5uo8B-6gsaE:
undetectable		 5uo8A-6gsaE:
undetectable
5uo8B-6gsaE:
undetectable