SIMILAR PATTERNS OF AMINO ACIDS FOR 5UO7_A_H4BA802_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyx R-PHYCOERYTHRIN

(Gracilaria
chilensis) 		PF00502
(Phycobilisome) 		4 SER A  26
ARG A  17
VAL A   8
GLU A  25
 None
 1.35A 5uo7A-1eyxA:
undetectable
5uo7B-1eyxA:
1.6		 5uo7A-1eyxA:
18.46
5uo7B-1eyxA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fep FERRIC ENTEROBACTIN
RECEPTOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 SER A 612
MET A 621
VAL A 578
TRP A 613
 None
 1.34A 5uo7A-1fepA:
undetectable
5uo7B-1fepA:
undetectable		 5uo7A-1fepA:
20.56
5uo7B-1fepA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3j PEROXIDASE

(Coprinopsis
cinerea) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 MET A 268
VAL A 177
TRP A 258
PHE A 211
 None
None
None
HSO  A 183 ( 3.5A)
 1.34A 5uo7A-1h3jA:
undetectable
5uo7B-1h3jA:
undetectable		 5uo7A-1h3jA:
22.59
5uo7B-1h3jA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		4 MET A 815
VAL A 707
TRP A 819
GLU A 814
 None
 1.13A 5uo7A-1jqoA:
0.0
5uo7B-1jqoA:
undetectable		 5uo7A-1jqoA:
17.67
5uo7B-1jqoA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfu M-CALPAIN LARGE
SUBUNIT

(Homo sapiens) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		4 SER L 236
ARG L 500
PHE L 502
GLU L 339
 None
 0.90A 5uo7A-1kfuL:
0.0
5uo7B-1kfuL:
0.0		 5uo7A-1kfuL:
20.66
5uo7B-1kfuL:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kh2 ARGININOSUCCINATE
SYNTHETASE

(Thermus
thermophilus) 		PF00764
(Arginosuc_synth) 		4 ARG A 282
VAL A 226
PHE A 220
GLU A 222
 None
 1.29A 5uo7A-1kh2A:
0.1
5uo7B-1kh2A:
0.1		 5uo7A-1kh2A:
23.65
5uo7B-1kh2A:
23.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		5 SER A 334
MET A 336
ARG A 596
VAL A 677
TRP A 678
 None
H4B  A 760 ( 3.8A)
H4B  A 760 (-3.5A)
H4B  A 760 (-4.6A)
H4B  A 760 ( 3.6A)
 0.60A 5uo7A-1lzxA:
61.4
5uo7B-1lzxA:
61.9		 5uo7A-1lzxA:
96.90
5uo7B-1lzxA:
96.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m5y SURVIVAL PROTEIN
SURA

(Escherichia
coli) 		PF00639
(Rotamase)
PF09312
(SurA_N)
PF13616
(Rotamase_3) 		4 SER A 412
MET A 414
TRP A 413
PHE A 406
 None
 1.27A 5uo7A-1m5yA:
undetectable
5uo7B-1m5yA:
0.0		 5uo7A-1m5yA:
25.00
5uo7B-1m5yA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzb FERRIC UPTAKE
REGULATION PROTEIN

(Pseudomonas
aeruginosa) 		PF01475
(FUR) 		4 ARG A  69
VAL A  54
PHE A  79
GLU A  36
 None
 1.01A 5uo7A-1mzbA:
0.3
5uo7B-1mzbA:
undetectable		 5uo7A-1mzbA:
14.73
5uo7B-1mzbA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pdu NUCLEAR HORMONE
RECEPTOR HR38

(Drosophila
melanogaster) 		PF00104
(Hormone_recep) 		4 MET A 440
VAL A 401
TRP A 435
PHE A 432
 None
 0.88A 5uo7A-1pduA:
0.0
5uo7B-1pduA:
0.0		 5uo7A-1pduA:
20.53
5uo7B-1pduA:
20.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Mus musculus) 		PF02898
(NO_synthase) 		4 SER A 112
MET A 114
ARG A 375
TRP A 457
 H4B  A 901 (-4.8A)
H4B  A 901 (-4.0A)
H4B  A 901 (-3.4A)
H4B  A 901 ( 3.7A)
 0.75A 5uo7A-1qw5A:
57.9
5uo7B-1qw5A:
57.5		 5uo7A-1qw5A:
64.37
5uo7B-1qw5A:
64.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wf0 TAR DNA-BINDING
PROTEIN-43

(Homo sapiens) 		PF00076
(RRM_1) 		4 MET A  17
VAL A  35
PHE A  26
GLU A  21
 None
 1.16A 5uo7A-1wf0A:
undetectable
5uo7B-1wf0A:
undetectable		 5uo7A-1wf0A:
12.73
5uo7B-1wf0A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wql ETHYLBENZENE
DIOXYGENASE SMALL
SUBUNIT

(Pseudomonas
fluorescens) 		PF00866
(Ring_hydroxyl_B) 		4 ARG B 156
VAL B 128
PHE B 163
GLU B  26
 None
 1.15A 5uo7A-1wqlB:
undetectable
5uo7B-1wqlB:
undetectable		 5uo7A-1wqlB:
17.80
5uo7B-1wqlB:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys9 PROTEIN SPY1043

(Streptococcus
pyogenes) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 SER A 248
VAL A 225
PHE A  27
GLU A 251
 None
 1.35A 5uo7A-1ys9A:
undetectable
5uo7B-1ys9A:
undetectable		 5uo7A-1ys9A:
20.53
5uo7B-1ys9A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 ARG A 708
VAL A1424
PHE A 722
GLU A 693
 None
 1.07A 5uo7A-2b39A:
undetectable
5uo7B-2b39A:
undetectable		 5uo7A-2b39A:
13.24
5uo7B-2b39A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpn GLYCEROL KINASE

(Thermus
thermophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 SER A 322
ARG A 369
VAL A 310
GLU A 321
 None
 1.05A 5uo7A-2dpnA:
undetectable
5uo7B-2dpnA:
undetectable		 5uo7A-2dpnA:
20.67
5uo7B-2dpnA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE

(Pseudomonas
aeruginosa) 		PF00682
(HMGL-like) 		4 SER A  93
VAL A  95
PHE A  87
GLU A  92
 None
 0.89A 5uo7A-2ftpA:
undetectable
5uo7B-2ftpA:
undetectable		 5uo7A-2ftpA:
22.98
5uo7B-2ftpA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggm CENTRIN-2

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 MET A 145
VAL A 157
PHE A 162
GLU A 148
 None
 1.29A 5uo7A-2ggmA:
undetectable
5uo7B-2ggmA:
undetectable		 5uo7A-2ggmA:
16.79
5uo7B-2ggmA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glf PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Thermotoga
maritima) 		PF02127
(Peptidase_M18) 		4 ARG A 261
VAL A 443
PHE A  21
GLU A  17
 None
 1.21A 5uo7A-2glfA:
undetectable
5uo7B-2glfA:
undetectable		 5uo7A-2glfA:
23.30
5uo7B-2glfA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnl GLUTATHIONE
S-TRANSFERASE 1

(Onchocerca
volvulus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 SER A 148
MET A 151
PHE A 142
GLU A 147
 None
 1.33A 5uo7A-2hnlA:
undetectable
5uo7B-2hnlA:
undetectable		 5uo7A-2hnlA:
18.38
5uo7B-2hnlA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obh CENTRIN-2

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 MET A 145
VAL A 157
PHE A 162
GLU A 148
 None
CA  A1001 ( 4.9A)
None
None
 1.31A 5uo7A-2obhA:
undetectable
5uo7B-2obhA:
undetectable		 5uo7A-2obhA:
16.34
5uo7B-2obhA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pag HYPOTHETICAL PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF14567
(SUKH_5) 		4 SER A 123
VAL A 106
TRP A 127
PHE A  42
 None
 1.31A 5uo7A-2pagA:
undetectable
5uo7B-2pagA:
undetectable		 5uo7A-2pagA:
15.91
5uo7B-2pagA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA

(Desulfovibrio
vulgaris) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 MET A 370
TRP A 369
TRP A 368
GLU A 371
 None
 1.09A 5uo7A-2v4jA:
undetectable
5uo7B-2v4jA:
undetectable		 5uo7A-2v4jA:
21.09
5uo7B-2v4jA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xw7 DIHYDROFOLATE
REDUCTASE

(Mycolicibacterium
smegmatis) 		PF01872
(RibD_C) 		4 SER A 150
VAL A 122
TRP A 152
GLU A 151
 None
 1.24A 5uo7A-2xw7A:
undetectable
5uo7B-2xw7A:
undetectable		 5uo7A-2xw7A:
18.14
5uo7B-2xw7A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywb GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Thermus
thermophilus) 		PF00117
(GATase)
PF00958
(GMP_synt_C) 		4 ARG A 211
VAL A 239
PHE A 309
GLU A 305
 None
 1.31A 5uo7A-2ywbA:
undetectable
5uo7B-2ywbA:
undetectable		 5uo7A-2ywbA:
22.74
5uo7B-2ywbA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		4 SER A  21
TRP A 397
PHE A 400
GLU A 396
 None
 1.33A 5uo7A-2z23A:
undetectable
5uo7B-2z23A:
undetectable		 5uo7A-2z23A:
21.11
5uo7B-2z23A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zf8 COMPONENT OF
SODIUM-DRIVEN POLAR
FLAGELLAR MOTOR

(Vibrio
alginolyticus) 		PF00691
(OmpA) 		4 MET A  17
TRP A  15
PHE A 137
GLU A  16
 None
 1.32A 5uo7A-2zf8A:
undetectable
5uo7B-2zf8A:
undetectable		 5uo7A-2zf8A:
20.28
5uo7B-2zf8A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a24 ALPHA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		4 SER A  60
VAL A  68
TRP A  69
GLU A 140
 None
 1.17A 5uo7A-3a24A:
undetectable
5uo7B-3a24A:
0.9		 5uo7A-3a24A:
19.82
5uo7B-3a24A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7f GLYCOSYL HYDROLASE,
BNR REPEAT

(Cupriavidus
pinatubonensis) 		no annotation 4 VAL A 314
TRP A 293
TRP A 374
GLU A 372
 None
None
None
EDO  A 404 ( 3.8A)
 1.33A 5uo7A-3b7fA:
undetectable
5uo7B-3b7fA:
undetectable		 5uo7A-3b7fA:
20.22
5uo7B-3b7fA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3be4 ADENYLATE KINASE

(Cryptosporidium
parvum) 		PF00406
(ADK)
PF05191
(ADK_lid) 		4 SER A  60
ARG A  93
VAL A 175
PHE A  63
 None
AP5  A 219 (-2.6A)
None
AP5  A 219 ( 4.7A)
 1.32A 5uo7A-3be4A:
undetectable
5uo7B-3be4A:
undetectable		 5uo7A-3be4A:
18.25
5uo7B-3be4A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjd PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE

(Pseudomonas
aeruginosa) 		PF14515
(HOASN)
PF14518
(Haem_oxygenas_2) 		4 SER A 127
ARG A 256
VAL A 130
GLU A 122
 None
 1.31A 5uo7A-3bjdA:
undetectable
5uo7B-3bjdA:
undetectable		 5uo7A-3bjdA:
20.75
5uo7B-3bjdA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3by9 SENSOR PROTEIN

(Vibrio cholerae) 		PF02743
(dCache_1) 		4 SER A 205
MET A 203
TRP A 185
GLU A 182
 None
 1.29A 5uo7A-3by9A:
undetectable
5uo7B-3by9A:
undetectable		 5uo7A-3by9A:
23.77
5uo7B-3by9A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d2w TAR DNA-BINDING
PROTEIN 43

(Mus musculus) 		PF00076
(RRM_1) 		4 MET A 202
VAL A 220
PHE A 211
GLU A 206
 None
 0.97A 5uo7A-3d2wA:
undetectable
5uo7B-3d2wA:
undetectable		 5uo7A-3d2wA:
12.72
5uo7B-3d2wA:
12.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		4 SER A 118
MET A 120
ARG A 381
TRP A 463
 None
H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 ( 3.6A)
 0.65A 5uo7A-3e7gA:
57.2
5uo7B-3e7gA:
56.7		 5uo7A-3e7gA:
65.80
5uo7B-3e7gA:
65.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efa PUTATIVE
ACETYLTRANSFERASE

(Lactobacillus
plantarum) 		PF13673
(Acetyltransf_10) 		4 SER A  30
ARG A  19
VAL A  24
PHE A  35
 None
 1.28A 5uo7A-3efaA:
undetectable
5uo7B-3efaA:
undetectable		 5uo7A-3efaA:
15.67
5uo7B-3efaA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eli AHA1 DOMAIN PROTEIN

(Ruegeria
pomeroyi) 		PF08327
(AHSA1) 		4 SER A  97
VAL A  99
TRP A  84
GLU A  96
 None
 1.35A 5uo7A-3eliA:
undetectable
5uo7B-3eliA:
undetectable		 5uo7A-3eliA:
16.27
5uo7B-3eliA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez0 UNCHARACTERIZED
PROTEIN WITH
FERRITIN-LIKE FOLD

(Arthrobacter
sp. FB24) 		PF13794
(MiaE_2) 		4 SER A 119
ARG A  66
VAL A 122
GLU A 131
 None
 1.32A 5uo7A-3ez0A:
undetectable
5uo7B-3ez0A:
undetectable		 5uo7A-3ez0A:
17.58
5uo7B-3ez0A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0p MALATE DEHYDROGENASE

(Entamoeba
histolytica) 		PF02615
(Ldh_2) 		4 SER A 277
ARG A 148
PHE A 280
GLU A 273
 None
 1.26A 5uo7A-3i0pA:
0.9
5uo7B-3i0pA:
1.6		 5uo7A-3i0pA:
21.23
5uo7B-3i0pA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1u BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE

(Clostridium
acetobutylicum) 		PF04616
(Glyco_hydro_43) 		4 SER A 262
VAL A 275
PHE A  29
GLU A  75
 None
None
None
MG  A 409 (-3.1A)
 1.11A 5uo7A-3k1uA:
undetectable
5uo7B-3k1uA:
undetectable		 5uo7A-3k1uA:
21.02
5uo7B-3k1uA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k28 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
2

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		4 SER A 189
VAL A 182
PHE A 222
GLU A 188
 None
 1.30A 5uo7A-3k28A:
undetectable
5uo7B-3k28A:
undetectable		 5uo7A-3k28A:
22.15
5uo7B-3k28A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5z FEM-3 MRNA-BINDING
FACTOR 2

(Caenorhabditis
elegans) 		PF00806
(PUF) 		4 MET A 471
ARG A 518
TRP A 534
PHE A 531
 None
 1.33A 5uo7A-3k5zA:
undetectable
5uo7B-3k5zA:
undetectable		 5uo7A-3k5zA:
22.98
5uo7B-3k5zA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kve L-AMINO ACID OXIDASE

(Vipera
ammodytes) 		PF01593
(Amino_oxidase) 		4 SER A 468
ARG A 478
PHE A  19
GLU A 461
 None
 1.34A 5uo7A-3kveA:
undetectable
5uo7B-3kveA:
undetectable		 5uo7A-3kveA:
21.26
5uo7B-3kveA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		4 MET A 786
VAL A 832
TRP A 819
GLU A 787
 None
 1.31A 5uo7A-3lltA:
undetectable
5uo7B-3lltA:
undetectable		 5uo7A-3lltA:
21.06
5uo7B-3lltA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mga ENTEROCHELIN
ESTERASE

(Salmonella
enterica) 		PF00756
(Esterase)
PF11806
(DUF3327) 		4 SER A 310
ARG A 114
VAL A 353
TRP A 314
 None
 1.14A 5uo7A-3mgaA:
undetectable
5uo7B-3mgaA:
undetectable		 5uo7A-3mgaA:
20.73
5uo7B-3mgaA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mga ENTEROCHELIN
ESTERASE

(Salmonella
enterica) 		PF00756
(Esterase)
PF11806
(DUF3327) 		4 SER A 310
ARG A 118
VAL A 353
TRP A 314
 None
GOL  A 407 ( 4.6A)
None
None
 0.89A 5uo7A-3mgaA:
undetectable
5uo7B-3mgaA:
undetectable		 5uo7A-3mgaA:
20.73
5uo7B-3mgaA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mxz TUBULIN-SPECIFIC
CHAPERONE A

(Arabidopsis
thaliana) 		PF02970
(TBCA) 		4 SER A  58
MET A  60
VAL A  28
GLU A  57
 None
 1.29A 5uo7A-3mxzA:
undetectable
5uo7B-3mxzA:
undetectable		 5uo7A-3mxzA:
16.08
5uo7B-3mxzA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3or2 SULFITE REDCUTASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF01077
(NIR_SIR) 		4 MET A 370
TRP A 369
TRP A 368
GLU A 371
 None
 1.29A 5uo7A-3or2A:
undetectable
5uo7B-3or2A:
undetectable		 5uo7A-3or2A:
20.67
5uo7B-3or2A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owc PROBABLE
ACETYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00583
(Acetyltransf_1) 		4 ARG A 175
VAL A  92
PHE A 121
GLU A 119
 None
 1.23A 5uo7A-3owcA:
1.7
5uo7B-3owcA:
1.6		 5uo7A-3owcA:
17.73
5uo7B-3owcA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjy ENDOGLUCANASE
FNCEL5A

(Fervidobacterium
nodosum) 		PF00150
(Cellulase) 		4 VAL A 149
TRP A 146
PHE A 162
GLU A 187
 None
 1.28A 5uo7A-3rjyA:
1.4
5uo7B-3rjyA:
1.4		 5uo7A-3rjyA:
20.54
5uo7B-3rjyA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqu NON-CANONICAL PURINE
NTP PYROPHOSPHATASE

(Coxiella
burnetii) 		PF01725
(Ham1p_like) 		4 VAL A 162
TRP A 140
PHE A 118
GLU A 141
 None
 1.22A 5uo7A-3tquA:
undetectable
5uo7B-3tquA:
undetectable		 5uo7A-3tquA:
19.76
5uo7B-3tquA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uet ALPHA-1,3/4-FUCOSIDA
SE

(Bifidobacterium
longum) 		PF01120
(Alpha_L_fucos) 		4 SER A 464
ARG A 445
VAL A 461
GLU A 419
 None
 1.23A 5uo7A-3uetA:
undetectable
5uo7B-3uetA:
undetectable		 5uo7A-3uetA:
22.08
5uo7B-3uetA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor) 		PF00195
(Chal_sti_synt_N) 		4 SER A 202
VAL A 200
PHE A 353
GLU A 203
 None
 1.14A 5uo7A-3v7iA:
undetectable
5uo7B-3v7iA:
0.4		 5uo7A-3v7iA:
20.34
5uo7B-3v7iA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0s HYGROMYCIN-B
4-O-KINASE

(Escherichia
coli) 		PF01636
(APH) 		4 SER A 218
TRP A 217
PHE A 136
GLU A 219
 HY0  A 401 (-3.5A)
None
None
HY0  A 401 (-4.0A)
 1.21A 5uo7A-3w0sA:
undetectable
5uo7B-3w0sA:
undetectable		 5uo7A-3w0sA:
19.95
5uo7B-3w0sA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgd PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT) 		4 VAL C2274
TRP C2314
PHE C2329
GLU C2310
 None
 1.31A 5uo7A-4bgdC:
undetectable
5uo7B-4bgdC:
undetectable		 5uo7A-4bgdC:
20.63
5uo7B-4bgdC:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ce4 MRPL44

(Sus scrofa) 		no annotation 4 SER h 131
ARG h 192
PHE h 196
GLU h 127
 None
 1.18A 5uo7A-4ce4h:
undetectable
5uo7B-4ce4h:
undetectable		 5uo7A-4ce4h:
19.91
5uo7B-4ce4h:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Aeropyrum
pernix) 		PF01269
(Fibrillarin) 		4 SER A  88
MET A 115
VAL A 121
GLU A 109
 None
None
None
SAM  A 301 (-2.9A)
 1.31A 5uo7A-4df3A:
undetectable
5uo7B-4df3A:
undetectable		 5uo7A-4df3A:
19.91
5uo7B-4df3A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gym GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Conexibacter
woesei) 		no annotation 4 SER A 116
TRP A 125
PHE A  91
GLU A 126
 None
 1.21A 5uo7A-4gymA:
undetectable
5uo7B-4gymA:
undetectable		 5uo7A-4gymA:
15.71
5uo7B-4gymA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN

(Lactobacillus
acidophilus) 		PF06100
(MCRA) 		4 SER A  36
MET A 517
ARG A  95
VAL A  39
 None
 1.27A 5uo7A-4ia5A:
undetectable
5uo7B-4ia5A:
undetectable		 5uo7A-4ia5A:
21.29
5uo7B-4ia5A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kdz TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Escherichia
coli) 		PF00588
(SpoU_methylase) 		4 SER A  87
ARG A  74
PHE A  76
GLU A 143
 None
 1.26A 5uo7A-4kdzA:
1.0
5uo7B-4kdzA:
undetectable		 5uo7A-4kdzA:
16.95
5uo7B-4kdzA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 ARYLPHORIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 VAL B 351
TRP B 355
PHE B 327
GLU B 424
 None
 1.05A 5uo7A-4l37B:
undetectable
5uo7B-4l37B:
undetectable		 5uo7A-4l37B:
19.86
5uo7B-4l37B:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		4 SER A 787
MET A 789
TRP A 788
GLU A 539
 None
 1.20A 5uo7A-4lglA:
undetectable
5uo7B-4lglA:
undetectable		 5uo7A-4lglA:
19.43
5uo7B-4lglA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmv GLUTATHIONE
TRANSFERASE

(Phanerochaete
chrysosporium) 		PF13417
(GST_N_3) 		4 ARG A  29
VAL A  73
PHE A   7
GLU A  42
 None
FLC  A 300 (-4.1A)
None
None
 1.09A 5uo7A-4lmvA:
undetectable
5uo7B-4lmvA:
undetectable		 5uo7A-4lmvA:
21.09
5uo7B-4lmvA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mln PREDICTED HD
PHOSPHOHYDROLASE
PHNZ

(uncultured
bacterium
HF130_AEPn_1) 		PF01966
(HD) 		4 MET A 180
VAL A   9
PHE A  93
GLU A 183
 None
 1.11A 5uo7A-4mlnA:
undetectable
5uo7B-4mlnA:
undetectable		 5uo7A-4mlnA:
16.99
5uo7B-4mlnA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6w PREDICTED HD
PHOSPHOHYDROLASE
PHNZ

(uncultured
bacterium
HF130_AEPn_1) 		PF01966
(HD) 		4 MET A 180
VAL A   9
PHE A  93
GLU A 183
 None
 1.16A 5uo7A-4n6wA:
undetectable
5uo7B-4n6wA:
undetectable		 5uo7A-4n6wA:
20.00
5uo7B-4n6wA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9x PUTATIVE
MONOOXYGENASE

(Pectobacterium
atrosepticum) 		PF01494
(FAD_binding_3) 		4 SER A  95
VAL A 386
PHE A 101
GLU A  97
 None
 1.32A 5uo7A-4n9xA:
undetectable
5uo7B-4n9xA:
undetectable		 5uo7A-4n9xA:
21.24
5uo7B-4n9xA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oro POLYMERASE PB2

(Influenza B
virus) 		PF00604
(Flu_PB2) 		4 SER A 407
ARG A 334
TRP A 359
PHE A 365
 None
GDP  A 501 (-4.1A)
GDP  A 501 (-3.3A)
None
 1.25A 5uo7A-4oroA:
undetectable
5uo7B-4oroA:
undetectable		 5uo7A-4oroA:
18.51
5uo7B-4oroA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pne METHYLTRANSFERASE-LI
KE PROTEIN

(Saccharopolyspora
spinosa) 		PF08241
(Methyltransf_11) 		4 ARG A  75
VAL A  79
PHE A 141
GLU A 162
 None
 1.32A 5uo7A-4pneA:
undetectable
5uo7B-4pneA:
undetectable		 5uo7A-4pneA:
21.10
5uo7B-4pneA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE SUBUNIT D

(Thermococcus
kodakarensis) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		4 SER D 162
VAL D 165
TRP D 168
GLU D 188
 None
 1.21A 5uo7A-4qiwD:
undetectable
5uo7B-4qiwD:
undetectable		 5uo7A-4qiwD:
20.09
5uo7B-4qiwD:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qo5 HYPOTHETICAL
MULTIHEME PROTEIN

(Ignicoccus
hospitalis) 		PF13435
(Cytochrome_C554)
PF13447
(Multi-haem_cyto) 		4 SER A 281
TRP A 278
PHE A 275
GLU A 280
 None
HEC  A 607 (-4.7A)
None
None
 1.31A 5uo7A-4qo5A:
undetectable
5uo7B-4qo5A:
undetectable		 5uo7A-4qo5A:
21.57
5uo7B-4qo5A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tq5 PRENYLTRANSFERASE

(Archaeoglobus
fulgidus) 		PF01040
(UbiA) 		4 SER A  64
TRP A  26
TRP A  60
PHE A  57
 None
 1.35A 5uo7A-4tq5A:
1.6
5uo7B-4tq5A:
1.5		 5uo7A-4tq5A:
19.91
5uo7B-4tq5A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj5 CYCLIC AMP-GMP
SYNTHASE

(Vibrio cholerae) 		no annotation 4 ARG A 280
VAL A 309
TRP A 267
PHE A 268
 None
 1.16A 5uo7A-4xj5A:
undetectable
5uo7B-4xj5A:
undetectable		 5uo7A-4xj5A:
22.63
5uo7B-4xj5A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj6 VC0179-LIKE PROTEIN

(Escherichia
coli) 		no annotation 4 ARG A 276
VAL A 305
PHE A 264
GLU A 266
 None
 1.16A 5uo7A-4xj6A:
undetectable
5uo7B-4xj6A:
undetectable		 5uo7A-4xj6A:
20.42
5uo7B-4xj6A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj6 VC0179-LIKE PROTEIN

(Escherichia
coli) 		no annotation 4 VAL A 305
TRP A 263
PHE A 264
GLU A 266
 None
 1.10A 5uo7A-4xj6A:
undetectable
5uo7B-4xj6A:
undetectable		 5uo7A-4xj6A:
20.42
5uo7B-4xj6A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z48 UNCHARACTERIZED
PROTEIN

(Desulfovibrio
piger) 		PF17131
(LolA_like) 		4 SER A 105
ARG A 127
VAL A 103
TRP A 104
 None
 1.12A 5uo7A-4z48A:
undetectable
5uo7B-4z48A:
undetectable		 5uo7A-4z48A:
20.57
5uo7B-4z48A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bni UNCHARACTERIZED
PROTEIN

(Sus scrofa) 		PF02267
(Rib_hydrolayse) 		4 SER A 163
VAL A 189
TRP A 193
PHE A  94
 None
 1.30A 5uo7A-5bniA:
undetectable
5uo7B-5bniA:
undetectable		 5uo7A-5bniA:
21.19
5uo7B-5bniA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
ALPHA SUBUNIT

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 4 SER A 254
ARG A 518
VAL A 271
PHE A 206
 None
 1.17A 5uo7A-5c2vA:
undetectable
5uo7B-5c2vA:
undetectable		 5uo7A-5c2vA:
18.34
5uo7B-5c2vA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cqs ELONGATOR COMPLEX
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF04762
(IKI3) 		4 SER A 985
VAL A 997
PHE A 968
GLU A 982
 None
 1.31A 5uo7A-5cqsA:
undetectable
5uo7B-5cqsA:
undetectable		 5uo7A-5cqsA:
20.39
5uo7B-5cqsA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1p ATP-DEPENDENT RNA
LIGASE

(Methanothermobacter
thermautotrophicus) 		PF09414
(RNA_ligase) 		4 MET A  98
ARG A 192
VAL A 234
GLU A 151
 APK  A  97 ( 4.2A)
None
APK  A  97 ( 4.3A)
APK  A  97 ( 3.0A)
 1.23A 5uo7A-5d1pA:
undetectable
5uo7B-5d1pA:
undetectable		 5uo7A-5d1pA:
23.21
5uo7B-5d1pA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dku PREX DNA POLYMERASE

(Plasmodium
falciparum) 		PF00476
(DNA_pol_A)
PF01612
(DNA_pol_A_exo1) 		4 SER A 626
TRP A 624
PHE A 406
GLU A 396
 None
 1.31A 5uo7A-5dkuA:
undetectable
5uo7B-5dkuA:
undetectable		 5uo7A-5dkuA:
19.44
5uo7B-5dkuA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5w GLYCINE--TRNA LIGASE
ALPHA SUBUNIT

(Aquifex
aeolicus) 		PF02091
(tRNA-synt_2e) 		4 SER A 220
ARG A 269
VAL A 224
GLU A 217
 None
 1.34A 5uo7A-5f5wA:
undetectable
5uo7B-5f5wA:
undetectable		 5uo7A-5f5wA:
21.23
5uo7B-5f5wA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjn L-AMINO ACID
DEAMINASE

(Cosenzaea
myxofaciens) 		PF01266
(DAO) 		4 ARG A 316
VAL A 438
TRP A 439
GLU A 418
 BE2  A1476 (-4.0A)
BE2  A1476 ( 4.3A)
BE2  A1476 ( 3.7A)
None
 1.30A 5uo7A-5fjnA:
undetectable
5uo7B-5fjnA:
undetectable		 5uo7A-5fjnA:
23.66
5uo7B-5fjnA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6

(Homo sapiens) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		4 SER B 884
ARG B 644
VAL B 671
PHE B 633
 None
 1.23A 5uo7A-5gjeB:
undetectable
5uo7B-5gjeB:
undetectable		 5uo7A-5gjeB:
19.97
5uo7B-5gjeB:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iwz SYNAPTONEMAL COMPLEX
PROTEIN 2

(Mus musculus) 		no annotation 4 SER A 201
TRP A 239
PHE A 249
GLU A 205
 None
 1.10A 5uo7A-5iwzA:
undetectable
5uo7B-5iwzA:
undetectable		 5uo7A-5iwzA:
22.27
5uo7B-5iwzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kn8 ADENINE DNA
GLYCOSYLASE

(Geobacillus
stearothermophilus) 		PF00633
(HHH)
PF00730
(HhH-GPD) 		4 VAL A  92
TRP A  83
PHE A  61
GLU A  84
 None
 1.36A 5uo7A-5kn8A:
undetectable
5uo7B-5kn8A:
undetectable		 5uo7A-5kn8A:
21.21
5uo7B-5kn8A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 SER A 149
VAL A 248
TRP A 150
PHE A 164
 None
None
CU  A 601 ( 4.4A)
None
 1.19A 5uo7A-5lm8A:
undetectable
5uo7B-5lm8A:
undetectable		 5uo7A-5lm8A:
20.81
5uo7B-5lm8A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		4 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.05A 5uo7A-5m8tA:
undetectable
5uo7B-5m8tA:
undetectable		 5uo7A-5m8tA:
20.25
5uo7B-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE

(Archaeoglobus
fulgidus) 		no annotation 4 SER A 278
ARG A  44
PHE A  43
GLU A 282
 None
 1.30A 5uo7A-5mqzA:
undetectable
5uo7B-5mqzA:
undetectable		 5uo7A-5mqzA:
11.88
5uo7B-5mqzA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olp PECTATE LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 SER A 133
ARG A 207
VAL A 120
PHE A 139
 None
 1.35A 5uo7A-5olpA:
undetectable
5uo7B-5olpA:
undetectable		 5uo7A-5olpA:
20.44
5uo7B-5olpA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tul TETRACYCLINE
DESTRUCTASE TET(55)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		4 SER A 350
TRP A 346
PHE A 343
GLU A 349
 None
 1.21A 5uo7A-5tulA:
undetectable
5uo7B-5tulA:
undetectable		 5uo7A-5tulA:
21.00
5uo7B-5tulA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE

(Homo sapiens) 		PF04095
(NAPRTase) 		4 SER A 398
VAL A 153
PHE A 132
GLU A  38
 SO4  A 502 (-2.8A)
None
None
None
 1.32A 5uo7A-5u2nA:
undetectable
5uo7B-5u2nA:
undetectable		 5uo7A-5u2nA:
20.81
5uo7B-5u2nA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w62 APOPTOSIS REGULATOR
BAX

(Mus musculus) 		no annotation 4 SER A  62
ARG A  34
PHE A  30
GLU A  61
 None
 1.21A 5uo7A-5w62A:
2.3
5uo7B-5w62A:
1.9		 5uo7A-5w62A:
11.75
5uo7B-5w62A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE

(Escherichia
coli) 		no annotation 4 SER A 224
ARG A  24
TRP A 219
GLU A 222
 None
 1.14A 5uo7A-5wlyA:
undetectable
5uo7B-5wlyA:
undetectable		 5uo7A-5wlyA:
11.66
5uo7B-5wlyA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xct VH(S112C)-SARAH
CHIMERA

(Homo sapiens;
Mus musculus) 		PF07686
(V-set)
PF11629
(Mst1_SARAH) 		4 VAL A  37
TRP A  47
PHE A  69
GLU A  95
 None
 1.30A 5uo7A-5xctA:
undetectable
5uo7B-5xctA:
undetectable		 5uo7A-5xctA:
17.81
5uo7B-5xctA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwd VH CHAIN OF 059-152
VL CHAIN OF 059-152

(Homo sapiens) 		no annotation 4 MET H 105
VAL D  98
TRP D  91
TRP H  49
 None
 1.16A 5uo7A-5xwdH:
undetectable
5uo7B-5xwdH:
undetectable		 5uo7A-5xwdH:
13.62
5uo7B-5xwdH:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk1 UDP-GLYCOSYLTRANSFER
ASE 79

(Oryza sativa) 		no annotation 4 ARG A 331
VAL A 317
TRP A 316
GLU A 322
 None
UDP  A 501 ( 4.8A)
None
None
 1.26A 5uo7A-6bk1A:
undetectable
5uo7B-6bk1A:
undetectable		 5uo7A-6bk1A:
13.48
5uo7B-6bk1A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c1d UNCONVENTIONAL
MYOSIN-IB

(Rattus
norvegicus) 		no annotation 4 SER P 186
MET P 170
VAL P 365
PHE P 166
 None
 1.21A 5uo7A-6c1dP:
undetectable
5uo7B-6c1dP:
undetectable		 5uo7A-6c1dP:
11.81
5uo7B-6c1dP:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d7t TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6

(Homo sapiens) 		no annotation 4 SER A 112
MET A  78
PHE A 152
GLU A 113
 None
 1.21A 5uo7A-6d7tA:
0.1
5uo7B-6d7tA:
undetectable		 5uo7A-6d7tA:
undetectable
5uo7B-6d7tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 4 MET A 393
VAL A 431
TRP A 421
GLU A 394
 None
 1.32A 5uo7A-6fylA:
undetectable
5uo7B-6fylA:
undetectable		 5uo7A-6fylA:
undetectable
5uo7B-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 4 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.33A 5uo7A-6fyoA:
undetectable
5uo7B-6fyoA:
undetectable		 5uo7A-6fyoA:
undetectable
5uo7B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 4 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.24A 5uo7A-6fyvA:
undetectable
5uo7B-6fyvA:
undetectable		 5uo7A-6fyvA:
undetectable
5uo7B-6fyvA:
undetectable