SIMILAR PATTERNS OF AMINO ACIDS FOR 5UO6_A_H4BA802_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3j PEROXIDASE

(Coprinopsis
cinerea) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 MET A 268
VAL A 177
TRP A 258
PHE A 211
 None
None
None
HSO  A 183 ( 3.5A)
 1.35A 5uo6A-1h3jA:
1.0
5uo6B-1h3jA:
1.1		 5uo6A-1h3jA:
22.59
5uo6B-1h3jA:
22.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		4 MET A 336
ARG A 596
VAL A 677
TRP A 678
 H4B  A 760 ( 3.8A)
H4B  A 760 (-3.5A)
H4B  A 760 (-4.6A)
H4B  A 760 ( 3.6A)
 0.60A 5uo6A-1lzxA:
21.7
5uo6B-1lzxA:
59.9		 5uo6A-1lzxA:
96.90
5uo6B-1lzxA:
96.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pdu NUCLEAR HORMONE
RECEPTOR HR38

(Drosophila
melanogaster) 		PF00104
(Hormone_recep) 		4 MET A 440
VAL A 401
TRP A 435
PHE A 432
 None
 0.91A 5uo6A-1pduA:
0.0
5uo6B-1pduA:
0.0		 5uo6A-1pduA:
20.53
5uo6B-1pduA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1j HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF09152
(DUF1937) 		4 ARG A   2
VAL A  28
TRP A 110
PHE A 117
 None
 1.47A 5uo6A-1t1jA:
0.0
5uo6B-1t1jA:
0.0		 5uo6A-1t1jA:
15.63
5uo6B-1t1jA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV

(Homo sapiens) 		PF00069
(Pkinase) 		4 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.41A 5uo6A-2w4oA:
0.0
5uo6B-2w4oA:
0.0		 5uo6A-2w4oA:
21.36
5uo6B-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5z FEM-3 MRNA-BINDING
FACTOR 2

(Caenorhabditis
elegans) 		PF00806
(PUF) 		4 MET A 471
ARG A 518
TRP A 534
PHE A 531
 None
 1.36A 5uo6A-3k5zA:
0.0
5uo6B-3k5zA:
0.0		 5uo6A-3k5zA:
22.98
5uo6B-3k5zA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ma6 CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		4 ARG A 269
VAL A 260
TRP A 257
PHE A 252
 None
 1.40A 5uo6A-3ma6A:
0.0
5uo6B-3ma6A:
0.0		 5uo6A-3ma6A:
21.21
5uo6B-3ma6A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3u LIGNIN PEROXIDASE

(Trametopsis
cervina) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 MET A 259
VAL A 169
TRP A 249
PHE A 203
 None
 1.39A 5uo6A-3q3uA:
0.4
5uo6B-3q3uA:
0.5		 5uo6A-3q3uA:
21.64
5uo6B-3q3uA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g76 PHOSPHODIESTERASE

(Pseudomonas
aeruginosa) 		PF14859
(Colicin_M) 		4 MET A 258
VAL A 265
TRP A  62
PHE A  85
 None
 1.38A 5uo6A-4g76A:
0.0
5uo6B-4g76A:
0.0		 5uo6A-4g76A:
20.05
5uo6B-4g76A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj5 CYCLIC AMP-GMP
SYNTHASE

(Vibrio cholerae) 		no annotation 4 ARG A 280
VAL A 309
TRP A 267
PHE A 268
 None
 1.15A 5uo6A-4xj5A:
undetectable
5uo6B-4xj5A:
undetectable		 5uo6A-4xj5A:
22.63
5uo6B-4xj5A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwd VH CHAIN OF 059-152
VL CHAIN OF 059-152

(Homo sapiens) 		no annotation 4 MET H 105
VAL D  98
TRP D  91
TRP H  49
 None
 1.16A 5uo6A-5xwdH:
undetectable
5uo6B-5xwdH:
undetectable		 5uo6A-5xwdH:
13.62
5uo6B-5xwdH:
13.62