SIMILAR PATTERNS OF AMINO ACIDS FOR 5UMX_B_RBFB202_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp3 N-ACYL-D-GLUCOSAMINE
2-EPIMERASE

(Sus scrofa) 		PF07221
(GlcNAc_2-epim) 		5 LEU A 240
ASN A 228
GLN A 296
GLY A 300
GLN A 305
 None
 1.47A 5umxA-1fp3A:
0.0
5umxB-1fp3A:
0.0		 5umxA-1fp3A:
12.30
5umxB-1fp3A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3z PUTATIVE DEACETYLASE

(Streptococcus
mutans) 		PF01522
(Polysacc_deac_1) 		5 LEU A 229
GLN A 232
GLY A 142
HIS A 166
GLN A 194
 None
None
None
ZN  A1312 ( 3.3A)
None
 1.50A 5umxA-2w3zA:
0.0
5umxB-2w3zA:
0.0		 5umxA-2w3zA:
13.96
5umxB-2w3zA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay3 NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Chromohalobacter
salexigens) 		PF01370
(Epimerase) 		5 TRP A 212
ASN A 208
GLY A 115
HIS A 112
TRP A 213
 None
 1.49A 5umxA-3ay3A:
0.0
5umxB-3ay3A:
0.0		 5umxA-3ay3A:
18.34
5umxB-3ay3A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gua NON-STRUCTURAL
POLYPROTEIN

(Sindbis virus) 		PF01661
(Macro)
PF01707
(Peptidase_C9) 		5 LEU A1150
GLN A1244
ASN A1240
GLN A1041
GLN A1133
 None
 1.47A 5umxA-4guaA:
0.0
5umxB-4guaA:
0.0		 5umxA-4guaA:
8.61
5umxB-4guaA:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pne METHYLTRANSFERASE-LI
KE PROTEIN

(Saccharopolyspora
spinosa) 		PF08241
(Methyltransf_11) 		5 LEU A  30
GLN A 233
GLY A  43
HIS A  41
TRP A  53
 MLI  A 302 ( 4.7A)
None
None
SAH  A 301 ( 3.6A)
None
 1.33A 5umxA-4pneA:
0.0
5umxB-4pneA:
0.9		 5umxA-4pneA:
21.37
5umxB-4pneA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qa9 EPOXIDE HYDROLASE

(Streptomyces
carzinostaticus) 		PF06441
(EHN) 		5 LEU A 260
GLN A 256
GLN A 301
GLY A 135
GLN A 238
 None
 1.35A 5umxA-4qa9A:
0.0
5umxB-4qa9A:
0.0		 5umxA-4qa9A:
14.90
5umxB-4qa9A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yio SUPEROXIDE DISMUTASE

(Streptococcus
thermophilus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 LEU A  86
TRP A 130
GLY A  75
HIS A  77
TRP A 128
 None
 1.48A 5umxA-4yioA:
0.0
5umxB-4yioA:
0.0		 5umxA-4yioA:
14.75
5umxB-4yioA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yip SUPEROXIDE DISMUTASE
[MN/FE]

(Streptococcus
mutans) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 LEU A  86
TRP A 130
GLY A  75
HIS A  77
TRP A 128
 None
 1.46A 5umxA-4yipA:
0.1
5umxB-4yipA:
0.0		 5umxA-4yipA:
18.68
5umxB-4yipA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 GLN A 529
GLN A 410
GLN A 119
GLY A 122
HIS A 154
 None
None
None
None
CU  A 602 ( 3.4A)
 1.31A 5umxA-5lm8A:
0.5
5umxB-5lm8A:
0.5		 5umxA-5lm8A:
8.82
5umxB-5lm8A:
8.82