SIMILAR PATTERNS OF AMINO ACIDS FOR 5UMW_B_RBFB201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b2h PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Salmonella
enterica) 		PF00496
(SBP_bac_5) 		4 VAL A 152
TYR A 420
GLU A 422
LEU A 431
 None
 1.05A 5umwB-1b2hA:
1.4
5umwE-1b2hA:
1.8		 5umwB-1b2hA:
8.90
5umwE-1b2hA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3r HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN)

(Aquifex
aeolicus) 		PF00850
(Hist_deacetyl) 		4 VAL A   4
TYR A 291
GLU A 288
LEU A 276
 None
 1.08A 5umwB-1c3rA:
0.0
5umwE-1c3rA:
0.0		 5umwB-1c3rA:
11.27
5umwE-1c3rA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evq SERINE HYDROLASE

(Alicyclobacillus
acidocaldarius) 		PF07859
(Abhydrolase_3) 		4 VAL A  45
ARG A  49
GLU A  47
LEU A 144
 None
 1.07A 5umwB-1evqA:
0.0
5umwE-1evqA:
0.0		 5umwB-1evqA:
12.50
5umwE-1evqA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lia R-PHYCOERYTHRIN

(Polysiphonia
urceolata) 		PF00502
(Phycobilisome) 		4 VAL A  52
ARG A  93
TYR B  18
LEU A 107
 None
CYC  A 175 ( 4.9A)
None
None
 1.01A 5umwB-1liaA:
undetectable
5umwE-1liaA:
undetectable		 5umwB-1liaA:
18.90
5umwE-1liaA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lia R-PHYCOERYTHRIN

(Polysiphonia
urceolata) 		PF00502
(Phycobilisome) 		4 VAL B  52
ARG B  93
TYR A  18
LEU B 107
 None
 1.12A 5umwB-1liaB:
undetectable
5umwE-1liaB:
undetectable		 5umwB-1liaB:
16.29
5umwE-1liaB:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2v PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 ARG B 570
TYR B 572
GLU B 597
LEU B 674
 None
 1.08A 5umwB-1m2vB:
0.0
5umwE-1m2vB:
0.0		 5umwB-1m2vB:
6.92
5umwE-1m2vB:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1now BETA-HEXOSAMINIDASE
BETA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		4 ARG A 279
GLU A 276
LEU A 169
ARG A 100
 None
 0.93A 5umwB-1nowA:
0.0
5umwE-1nowA:
0.0		 5umwB-1nowA:
10.24
5umwE-1nowA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q14 HST2 PROTEIN

(Saccharomyces
cerevisiae) 		PF02146
(SIR2) 		4 VAL A 219
ARG A 111
TYR A 113
TRP A 196
 None
 1.08A 5umwB-1q14A:
0.0
5umwE-1q14A:
0.0		 5umwB-1q14A:
12.47
5umwE-1q14A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1a HST2 PROTEIN

(Saccharomyces
cerevisiae) 		PF02146
(SIR2) 		4 VAL A 219
ARG A 111
TYR A 113
TRP A 196
 None
 1.07A 5umwB-1q1aA:
0.0
5umwE-1q1aA:
0.0		 5umwB-1q1aA:
15.25
5umwE-1q1aA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9k RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE C

(Escherichia
coli) 		PF00849
(PseudoU_synth_2) 		4 ARG A 316
TYR A 226
GLU A 224
LEU A 308
 None
 1.04A 5umwB-1v9kA:
0.0
5umwE-1v9kA:
0.0		 5umwB-1v9kA:
17.59
5umwE-1v9kA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdw HYPOTHETICAL PROTEIN
PH1897

(Pyrococcus
horikoshii) 		PF00459
(Inositol_P) 		4 ARG A 123
TYR A 125
GLU A 118
LEU A 187
 None
 1.04A 5umwB-1vdwA:
0.0
5umwE-1vdwA:
0.0		 5umwB-1vdwA:
14.17
5umwE-1vdwA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlj NADH-DEPENDENT
BUTANOL
DEHYDROGENASE

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		4 ARG A 307
TYR A 204
GLU A 218
LEU A 322
 None
 1.13A 5umwB-1vljA:
0.2
5umwE-1vljA:
0.4		 5umwB-1vljA:
12.91
5umwE-1vljA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6j LANOSTEROL SYNTHASE

(Homo sapiens) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		4 ARG A 162
TYR A 158
GLU A 262
LEU A 200
 None
 1.16A 5umwB-1w6jA:
undetectable
5umwE-1w6jA:
undetectable		 5umwB-1w6jA:
8.23
5umwE-1w6jA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima) 		PF03537
(Glyco_hydro_114) 		4 ARG A  99
TYR A 101
GLU A  96
LEU A 142
 UNL  A   1 (-3.9A)
None
UNL  A   1 (-4.2A)
None
 0.96A 5umwB-2aamA:
undetectable
5umwE-2aamA:
undetectable		 5umwB-2aamA:
16.16
5umwE-2aamA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1p IGH-4 PROTEIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL B  18
ARG B  38
TYR B  90
LEU B  59
 None
 0.92A 5umwB-2c1pB:
undetectable
5umwE-2c1pB:
undetectable		 5umwB-2c1pB:
15.21
5umwE-2c1pB:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cx9 ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 VAL A  14
ARG A  69
GLU A  11
ARG A  19
 None
 1.07A 5umwB-2cx9A:
undetectable
5umwE-2cx9A:
undetectable		 5umwB-2cx9A:
10.59
5umwE-2cx9A:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00456
(Transketolase_N) 		4 VAL A 668
TYR A 714
GLU A 665
LEU A 764
 None
 1.20A 5umwB-2g28A:
undetectable
5umwE-2g28A:
undetectable		 5umwB-2g28A:
7.62
5umwE-2g28A:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2)
no annotation 		4 ARG I 247
GLU I 244
LEU I 136
ARG A  67
 None
 1.01A 5umwB-2gk1I:
undetectable
5umwE-2gk1I:
undetectable		 5umwB-2gk1I:
11.36
5umwE-2gk1I:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2igt SAM DEPENDENT
METHYLTRANSFERASE

(Agrobacterium
fabrum) 		PF10672
(Methyltrans_SAM) 		4 VAL A 160
ARG A 197
GLU A 189
ARG A 185
 None
GOL  A1005 (-3.9A)
GOL  A1005 ( 3.1A)
GOL  A1005 ( 4.3A)
 0.97A 5umwB-2igtA:
undetectable
5umwE-2igtA:
undetectable		 5umwB-2igtA:
14.77
5umwE-2igtA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF01380
(SIS)
PF13522
(GATase_6) 		4 VAL A 376
ARG A  26
TYR A  25
GLU A 351
 None
 0.90A 5umwB-2j6hA:
undetectable
5umwE-2j6hA:
undetectable		 5umwB-2j6hA:
10.82
5umwE-2j6hA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jdj REDY-LIKE PROTEIN

(Hahella
chejuensis) 		PF11639
(HapK) 		4 VAL A  23
ARG A  44
TYR A  55
GLU A  20
 None
 1.16A 5umwB-2jdjA:
undetectable
5umwE-2jdjA:
undetectable		 5umwB-2jdjA:
18.10
5umwE-2jdjA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		4 ARG A 100
TYR A 164
GLU A 189
LEU A  95
 None
 1.12A 5umwB-2jgdA:
undetectable
5umwE-2jgdA:
undetectable		 5umwB-2jgdA:
6.75
5umwE-2jgdA:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjd RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE EPSILON

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 VAL A 267
ARG A 649
TYR A 490
GLU A 653
 None
 1.07A 5umwB-2jjdA:
1.5
5umwE-2jjdA:
undetectable		 5umwB-2jjdA:
8.89
5umwE-2jjdA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oew PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN

(Homo sapiens) 		PF03097
(BRO1) 		4 ARG A  50
TYR A  71
GLU A 119
LEU A  21
 None
 1.19A 5umwB-2oewA:
undetectable
5umwE-2oewA:
undetectable		 5umwB-2oewA:
15.91
5umwE-2oewA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0l LIPOATE-PROTEIN
LIGASE A

(Streptococcus
agalactiae) 		PF03099
(BPL_LplA_LipB) 		4 VAL A 231
TYR A  19
GLU A 232
LEU A  49
 None
 1.17A 5umwB-2p0lA:
undetectable
5umwE-2p0lA:
undetectable		 5umwB-2p0lA:
12.37
5umwE-2p0lA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkh HISTIDINE
UTILIZATION
REPRESSOR

(Pseudomonas
syringae group
genomosp. 3) 		PF07702
(UTRA) 		4 VAL A 184
ARG A 157
TYR A 167
LEU A 130
 None
 1.09A 5umwB-2pkhA:
undetectable
5umwE-2pkhA:
undetectable		 5umwB-2pkhA:
17.33
5umwE-2pkhA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN

(Homo sapiens) 		PF03097
(BRO1)
PF13949
(ALIX_LYPXL_bnd) 		4 ARG A  50
TYR A  71
GLU A 119
LEU A  21
 None
 1.18A 5umwB-2r05A:
undetectable
5umwE-2r05A:
undetectable		 5umwB-2r05A:
6.98
5umwE-2r05A:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vjh PHYCOERYTHRIN ALPHA
CHAIN
PHYCOERYTHRIN BETA
SUBUNIT

(Gloeobacter
violaceus) 		PF00502
(Phycobilisome) 		4 VAL A  52
ARG A  91
TYR B  18
LEU A 105
 None
 1.07A 5umwB-2vjhA:
undetectable
5umwE-2vjhA:
undetectable		 5umwB-2vjhA:
19.53
5umwE-2vjhA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w82 ORF18

(Enterococcus
faecalis) 		PF07275
(ArdA) 		4 VAL A 130
ARG A 118
TYR A 140
GLU A 122
 None
 1.05A 5umwB-2w82A:
undetectable
5umwE-2w82A:
undetectable		 5umwB-2w82A:
16.57
5umwE-2w82A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro) 		4 ARG A 444
TYR A 311
GLU A 437
LEU A 397
 None
 1.15A 5umwB-2xdqA:
undetectable
5umwE-2xdqA:
undetectable		 5umwB-2xdqA:
10.85
5umwE-2xdqA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv1 SUCCINYL-COA LIGASE
[ADP-FORMING]
SUBUNIT ALPHA

(Methanocaldococcus
jannaschii) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		4 ARG A 158
TYR A 193
GLU A 220
LEU A 162
 None
 1.01A 5umwB-2yv1A:
undetectable
5umwE-2yv1A:
undetectable		 5umwB-2yv1A:
14.13
5umwE-2yv1A:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		4 VAL A 152
TYR A 420
GLU A 422
LEU A 431
 None
 1.03A 5umwB-2z23A:
2.0
5umwE-2z23A:
1.9		 5umwB-2z23A:
10.53
5umwE-2z23A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a24 ALPHA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		4 ARG A  93
TYR A  92
GLU A 537
ARG A 492
 None
 1.18A 5umwB-3a24A:
undetectable
5umwE-3a24A:
undetectable		 5umwB-3a24A:
8.36
5umwE-3a24A:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahy BETA-GLUCOSIDASE

(Trichoderma
reesei) 		PF00232
(Glyco_hydro_1) 		4 VAL A 286
ARG A 136
GLU A 282
LEU A 275
 None
 0.94A 5umwB-3ahyA:
undetectable
5umwE-3ahyA:
undetectable		 5umwB-3ahyA:
11.44
5umwE-3ahyA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bm3 PSPGI RESTRICTION
ENDONUCLEASE

(Pyrococcus sp.
GI-H) 		PF09019
(EcoRII-C) 		4 VAL A  74
ARG A  96
TYR A  67
GLU A  71
 None
 1.04A 5umwB-3bm3A:
undetectable
5umwE-3bm3A:
undetectable		 5umwB-3bm3A:
16.08
5umwE-3bm3A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckb SUSD

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB) 		4 ARG A 437
GLU A 492
LEU A 225
ARG A 229
 None
 0.96A 5umwB-3ckbA:
undetectable
5umwE-3ckbA:
undetectable		 5umwB-3ckbA:
8.93
5umwE-3ckbA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3

(Mus musculus) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		4 VAL A 490
ARG A 382
GLU A 435
LEU A 413
 None
 1.14A 5umwB-3cwgA:
undetectable
5umwE-3cwgA:
undetectable		 5umwB-3cwgA:
8.54
5umwE-3cwgA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwu DNA-3-METHYLADENINE
GLYCOSYLASE 2

(Escherichia
coli) 		PF00730
(HhH-GPD)
PF06029
(AlkA_N) 		4 ARG A  37
TYR A  35
GLU A  28
ARG A 226
 None
 0.91A 5umwB-3cwuA:
undetectable
5umwE-3cwuA:
undetectable		 5umwB-3cwuA:
13.12
5umwE-3cwuA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dra PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA

(Candida
albicans) 		PF01239
(PPTA) 		4 ARG A 109
TYR A 149
GLU A 129
TRP A 152
 None
 1.18A 5umwB-3draA:
undetectable
5umwE-3draA:
undetectable		 5umwB-3draA:
12.42
5umwE-3draA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcr PUTATIVE
AMINOTRANSFERASE

(Ruegeria sp.
TM1040) 		PF00202
(Aminotran_3) 		4 ARG A 189
TYR A 186
GLU A 386
LEU A 165
 None
 1.19A 5umwB-3fcrA:
undetectable
5umwE-3fcrA:
undetectable		 5umwB-3fcrA:
9.98
5umwE-3fcrA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ff6 ACETYL-COA
CARBOXYLASE 2

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		4 VAL A2339
ARG A2332
GLU A2336
TRP A2384
 None
 1.15A 5umwB-3ff6A:
undetectable
5umwE-3ff6A:
undetectable		 5umwB-3ff6A:
8.23
5umwE-3ff6A:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE

(Oenococcus oeni) 		PF12697
(Abhydrolase_6) 		4 ARG A  49
TYR A  51
GLU A  39
LEU A 262
 None
CSO  A  35 ( 3.6A)
None
None
 1.20A 5umwB-3fsgA:
undetectable
5umwE-3fsgA:
undetectable		 5umwB-3fsgA:
13.66
5umwE-3fsgA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gju PUTATIVE
AMINOTRANSFERASE

(Mesorhizobium
japonicum) 		PF00202
(Aminotran_3) 		4 ARG A 190
TYR A 187
GLU A 387
LEU A 166
 None
 1.14A 5umwB-3gjuA:
undetectable
5umwE-3gjuA:
undetectable		 5umwB-3gjuA:
9.91
5umwE-3gjuA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gn6 CT0912, ORFAN
PROTEIN WITH A
FERREDOXIN-LIKE
DOMAIN REPEAT

(Chlorobaculum
tepidum) 		no annotation 4 VAL A 218
ARG A 259
TYR A 270
GLU A 215
 None
 0.97A 5umwB-3gn6A:
undetectable
5umwE-3gn6A:
undetectable		 5umwB-3gn6A:
12.46
5umwE-3gn6A:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jap EIF3C

(Saccharomyces
cerevisiae) 		PF00203
(Ribosomal_S19) 		4 ARG p 436
TYR p 405
GLU p 452
LEU p 413
 None
 1.10A 5umwB-3japp:
undetectable
5umwE-3japp:
undetectable		 5umwB-3japp:
0.00
5umwE-3japp:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kez PUTATIVE SUGAR
BINDING PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 VAL A  66
ARG A 357
GLU A 416
ARG A 225
 None
 0.80A 5umwB-3kezA:
undetectable
5umwE-3kezA:
undetectable		 5umwB-3kezA:
10.24
5umwE-3kezA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvv GLUTAMATE--CYSTEINE
LIGASE

(Saccharomyces
cerevisiae) 		PF03074
(GCS) 		4 ARG A 591
TYR A 595
GLU A 119
LEU A 659
 None
 0.99A 5umwB-3lvvA:
undetectable
5umwE-3lvvA:
undetectable		 5umwB-3lvvA:
7.21
5umwE-3lvvA:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		4 ARG A 374
TYR A 138
GLU A 379
LEU A 346
 None
 1.20A 5umwB-3nieA:
undetectable
5umwE-3nieA:
undetectable		 5umwB-3nieA:
12.25
5umwE-3nieA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3od1 ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Bacillus
halodurans) 		PF13393
(tRNA-synt_His) 		4 ARG A 102
TYR A  40
GLU A 141
ARG A 296
 None
 1.09A 5umwB-3od1A:
undetectable
5umwE-3od1A:
undetectable		 5umwB-3od1A:
14.02
5umwE-3od1A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3od1 ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Bacillus
halodurans) 		PF13393
(tRNA-synt_His) 		4 VAL A  77
ARG A  88
GLU A  49
LEU A 300
 None
 1.02A 5umwB-3od1A:
undetectable
5umwE-3od1A:
undetectable		 5umwB-3od1A:
14.02
5umwE-3od1A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)

(Mycobacterium
tuberculosis) 		PF00857
(Isochorismatase) 		4 VAL A 131
ARG A   2
TYR A  41
LEU A 120
 None
 0.96A 5umwB-3pl1A:
undetectable
5umwE-3pl1A:
undetectable		 5umwB-3pl1A:
19.43
5umwE-3pl1A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 VAL A 544
TYR A 126
GLU A 114
LEU A  41
 None
 1.16A 5umwB-3ppsA:
undetectable
5umwE-3ppsA:
undetectable		 5umwB-3ppsA:
9.09
5umwE-3ppsA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT M
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 4 VAL N 328
ARG M  74
GLU N 324
LEU M 190
 None
 1.20A 5umwB-3rkoN:
undetectable
5umwE-3rkoN:
undetectable		 5umwB-3rkoN:
9.73
5umwE-3rkoN:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1s FAB PGT145 HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H  18
ARG H  38
TYR H  90
LEU H  57
 None
 1.07A 5umwB-3u1sH:
undetectable
5umwE-3u1sH:
undetectable		 5umwB-3u1sH:
13.93
5umwE-3u1sH:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v57 PHYCOERYTHRIN ALPHA
SUBUNIT
PHYCOERYTHRIN BETA
SUBUNIT

(Porphyridium
purpureum) 		PF00502
(Phycobilisome) 		4 VAL A  52
ARG A  91
TYR B  18
LEU A 105
 None
 1.02A 5umwB-3v57A:
undetectable
5umwE-3v57A:
undetectable		 5umwB-3v57A:
19.51
5umwE-3v57A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vaa SHIKIMATE KINASE

(Bacteroides
thetaiotaomicron) 		PF01202
(SKI) 		4 ARG A  39
TYR A  35
GLU A  66
LEU A  47
 None
 1.20A 5umwB-3vaaA:
undetectable
5umwE-3vaaA:
undetectable		 5umwB-3vaaA:
20.71
5umwE-3vaaA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waf IRON ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING PROTEIN

(Thermus
thermophilus) 		PF13416
(SBP_bac_8) 		4 VAL A  39
TYR A  54
GLU A  36
ARG A  49
 None
 0.91A 5umwB-3wafA:
undetectable
5umwE-3wafA:
undetectable		 5umwB-3wafA:
14.39
5umwE-3wafA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apf CULLIN 3

(Homo sapiens) 		PF00888
(Cullin) 		4 VAL B 263
ARG B 247
GLU B 244
LEU B 166
 None
 1.11A 5umwB-4apfB:
undetectable
5umwE-4apfB:
undetectable		 5umwB-4apfB:
11.51
5umwE-4apfB:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asi ACETYL-COA
CARBOXYLASE 1

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		4 VAL A2265
ARG A2258
GLU A2262
TRP A2310
 None
 1.14A 5umwB-4asiA:
0.4
5umwE-4asiA:
undetectable		 5umwB-4asiA:
8.50
5umwE-4asiA:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Pseudomonas
aeruginosa) 		PF00483
(NTP_transferase) 		4 VAL A 292
TYR A 283
GLU A 255
LEU A 242
 None
None
N5Y  A1294 (-3.5A)
None
 1.16A 5umwB-4asyA:
undetectable
5umwE-4asyA:
undetectable		 5umwB-4asyA:
13.31
5umwE-4asyA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cxf RNA POLYMERASE SIGMA
FACTOR CNRH

(Cupriavidus
metallidurans) 		PF04542
(Sigma70_r2)
PF08281
(Sigma70_r4_2) 		4 VAL A 147
ARG A  84
TYR A  87
GLU A 144
 None
None
SO4  A1190 (-4.4A)
None
 1.12A 5umwB-4cxfA:
undetectable
5umwE-4cxfA:
undetectable		 5umwB-4cxfA:
19.27
5umwE-4cxfA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d5g CYCLOHEXANE-1,2-DION
E HYDROLASE

(Azoarcus sp.
BH72) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 VAL A 506
ARG A 531
TYR A 515
GLU A 517
 None
 1.14A 5umwB-4d5gA:
undetectable
5umwE-4d5gA:
undetectable		 5umwB-4d5gA:
10.75
5umwE-4d5gA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0t C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN

(Synechocystis
sp. PCC 6803) 		PF00502
(Phycobilisome) 		4 VAL A  52
ARG A  93
TYR B  18
LEU A 107
 None
 1.18A 5umwB-4f0tA:
undetectable
5umwE-4f0tA:
undetectable		 5umwB-4f0tA:
17.65
5umwE-4f0tA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqu PUTATIVE GLUTATHIONE
TRANSFERASE

(Sphingobium
chlorophenolicum) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		4 VAL A 152
ARG A  44
GLU A  41
LEU A 125
 None
 1.11A 5umwB-4fquA:
undetectable
5umwE-4fquA:
undetectable		 5umwB-4fquA:
14.69
5umwE-4fquA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE

(Bacillus
anthracis) 		PF00144
(Beta-lactamase) 		4 VAL A 287
TYR A  54
LEU A 201
TRP A  44
 None
 0.98A 5umwB-4gb7A:
undetectable
5umwE-4gb7A:
undetectable		 5umwB-4gb7A:
13.18
5umwE-4gb7A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ieg RNA-DEPENDENT RNA
POLYMERASE P2

(Pseudomonas
phage phi12) 		no annotation 4 ARG A 556
GLU A 525
TRP A 608
ARG A 623
 None
 1.14A 5umwB-4iegA:
undetectable
5umwE-4iegA:
undetectable		 5umwB-4iegA:
8.56
5umwE-4iegA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENC2

(Yersinia
entomophaga) 		no annotation 4 VAL B 618
ARG B 411
TYR B 409
LEU B 682
 None
 1.18A 5umwB-4iglB:
undetectable
5umwE-4iglB:
undetectable		 5umwB-4iglB:
6.67
5umwE-4iglB:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jot ENOYL-COA HYDRATASE,
PUTATIVE

(Deinococcus
radiodurans) 		PF00378
(ECH_1) 		4 VAL A 188
ARG A 201
GLU A 190
LEU A 209
 None
 1.17A 5umwB-4jotA:
undetectable
5umwE-4jotA:
undetectable		 5umwB-4jotA:
15.60
5umwE-4jotA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mad BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF01301
(Glyco_hydro_35) 		4 ARG A 117
TYR A 167
GLU A 155
LEU A 108
 None
 1.18A 5umwB-4madA:
undetectable
5umwE-4madA:
undetectable		 5umwB-4madA:
10.62
5umwE-4madA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbg CAAX
FARNESYLTRANSFERASE
ALPHA SUBUNIT RAM2

(Aspergillus
fumigatus) 		PF01239
(PPTA) 		4 ARG A 115
TYR A 152
GLU A 132
TRP A 155
 None
 1.16A 5umwB-4mbgA:
undetectable
5umwE-4mbgA:
undetectable		 5umwB-4mbgA:
14.53
5umwE-4mbgA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhc NUCLEOPORIN NUP157

(Saccharomyces
cerevisiae) 		PF08801
(Nucleoporin_N) 		4 ARG A 140
TYR A 612
GLU A 610
LEU A 560
 None
 0.97A 5umwB-4mhcA:
undetectable
5umwE-4mhcA:
undetectable		 5umwB-4mhcA:
6.57
5umwE-4mhcA:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nge PRESEQUENCE
PROTEASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		4 VAL D 701
ARG D 633
TYR D 632
GLU D 367
 None
MLY  D 363 ( 4.1A)
None
MLY  D 363 ( 4.3A)
 1.15A 5umwB-4ngeD:
undetectable
5umwE-4ngeD:
undetectable		 5umwB-4ngeD:
6.20
5umwE-4ngeD:
6.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ony EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 5

(Brucella
melitensis) 		PF00496
(SBP_bac_5) 		4 ARG A 282
TYR A 287
GLU A 277
LEU A 272
 None
 1.19A 5umwB-4onyA:
2.3
5umwE-4onyA:
2.4		 5umwB-4onyA:
10.55
5umwE-4onyA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		4 VAL A  73
TYR A  79
GLU A 327
LEU A   3
 None
None
None
SAC  A   2 ( 4.1A)
 1.15A 5umwB-4ouaA:
undetectable
5umwE-4ouaA:
undetectable		 5umwB-4ouaA:
11.26
5umwE-4ouaA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3

(Thermobaculum
terrenum) 		PF00271
(Helicase_C) 		4 ARG A 611
TYR A 607
GLU A 936
ARG A 932
 None
 0.93A 5umwB-4q2cA:
undetectable
5umwE-4q2cA:
undetectable		 5umwB-4q2cA:
8.56
5umwE-4q2cA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN

(Nitratireductor
pacificus) 		PF12838
(Fer4_7)
PF13486
(Dehalogenase) 		4 VAL A 457
ARG A 334
TYR A 392
GLU A 456
 None
 0.96A 5umwB-4rasA:
0.7
5umwE-4rasA:
1.3		 5umwB-4rasA:
7.50
5umwE-4rasA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB

(Lactococcus
lactis) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		4 ARG A 826
TYR A 827
GLU A 823
ARG A 966
 None
 1.19A 5umwB-4wd9A:
undetectable
5umwE-4wd9A:
undetectable		 5umwB-4wd9A:
5.63
5umwE-4wd9A:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9e DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE

(Escherichia
coli) 		PF01966
(HD) 		4 ARG A 477
TYR A 455
GLU A 473
LEU A 180
 None
 1.07A 5umwB-4x9eA:
undetectable
5umwE-4x9eA:
undetectable		 5umwB-4x9eA:
9.50
5umwE-4x9eA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
ORIGIN RECOGNITION
COMPLEX SUBUNIT 6

(Drosophila
melanogaster) 		PF07034
(ORC3_N)
no annotation 		4 ARG C 357
TYR F 225
GLU C 354
LEU F 233
 None
 1.01A 5umwB-4xgcC:
0.4
5umwE-4xgcC:
0.6		 5umwB-4xgcC:
8.94
5umwE-4xgcC:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xul MG662

(Megavirus
chiliensis) 		no annotation 4 VAL A  29
ARG A  55
TYR A  21
GLU A  26
 None
 1.09A 5umwB-4xulA:
undetectable
5umwE-4xulA:
0.8		 5umwB-4xulA:
14.17
5umwE-4xulA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b13 PHYCOERYTHRIN ALPHA
SUBUNIT
PHYCOERYTHRIN BETA
SUBUNIT

(Palmaria
palmata) 		PF00502
(Phycobilisome) 		4 VAL A  52
ARG A  91
TYR G  18
LEU A 105
 None
 1.08A 5umwB-5b13A:
undetectable
5umwE-5b13A:
undetectable		 5umwB-5b13A:
20.25
5umwE-5b13A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1q U14 PROTEIN

(Human
betaherpesvirus
6B) 		PF04637
(Herpes_pp85) 		4 VAL A  59
ARG A 255
GLU A 252
TRP A 259
 None
 1.19A 5umwB-5b1qA:
undetectable
5umwE-5b1qA:
undetectable		 5umwB-5b1qA:
10.22
5umwE-5b1qA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bo4 SUPPRESSOR OF
CYTOKINE SIGNALING 2

(Homo sapiens) 		PF00017
(SH2)
PF07525
(SOCS_box) 		4 VAL A 122
GLU A  42
LEU A 169
TRP A  48
 None
 1.19A 5umwB-5bo4A:
undetectable
5umwE-5bo4A:
undetectable		 5umwB-5bo4A:
19.65
5umwE-5bo4A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwe CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		4 ARG A 113
GLU A 148
LEU A 121
ARG A 157
 None
 1.05A 5umwB-5cweA:
undetectable
5umwE-5cweA:
undetectable		 5umwB-5cweA:
11.81
5umwE-5cweA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7t MINOR STRUCTURAL
PROTEIN 5

(Lactococcus
phage Tuc2009) 		no annotation 4 ARG B 232
TYR B 234
GLU B 271
LEU B  28
 None
 1.06A 5umwB-5e7tB:
undetectable
5umwE-5e7tB:
undetectable		 5umwB-5e7tB:
12.23
5umwE-5e7tB:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ebg T-CELL SURFACE
GLYCOPROTEIN CD8
ALPHA CHAIN

(Bos taurus) 		PF07686
(V-set) 		4 VAL A  19
ARG A  38
TYR A  94
LEU A  60
 None
 1.11A 5umwB-5ebgA:
undetectable
5umwE-5ebgA:
undetectable		 5umwB-5ebgA:
16.95
5umwE-5ebgA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz SPINDLE POLE BODY
COMPONENT SPC97

(Saccharomyces
cerevisiae) 		PF04130
(Spc97_Spc98) 		4 VAL A 149
ARG A 143
GLU A 147
LEU A 189
 None
 1.16A 5umwB-5flzA:
undetectable
5umwE-5flzA:
undetectable		 5umwB-5flzA:
5.72
5umwE-5flzA:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g06 EXOSOME COMPLEX
COMPONENT RRP42

(Saccharomyces
cerevisiae) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 VAL E 130
ARG E  49
GLU E  57
LEU E  41
 None
 1.20A 5umwB-5g06E:
undetectable
5umwE-5g06E:
undetectable		 5umwB-5g06E:
13.26
5umwE-5g06E:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i47 RIMK DOMAIN PROTEIN
ATP-GRASP

(Sphaerobacter
thermophilus) 		PF08443
(RimK) 		4 VAL A 264
ARG A 255
GLU A  14
ARG A 179
 None
 1.12A 5umwB-5i47A:
undetectable
5umwE-5i47A:
undetectable		 5umwB-5i47A:
15.94
5umwE-5i47A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbk BETA-GLUCOSIDASE

(Trichoderma
harzianum) 		PF00232
(Glyco_hydro_1) 		4 VAL A 286
ARG A 137
GLU A 282
LEU A 275
 None
 1.06A 5umwB-5jbkA:
undetectable
5umwE-5jbkA:
undetectable		 5umwB-5jbkA:
10.96
5umwE-5jbkA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME

(Pseudomonas
savastanoi) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		4 VAL A  79
ARG A 174
GLU A  94
LEU A 272
 None
 1.20A 5umwB-5lunA:
undetectable
5umwE-5lunA:
undetectable		 5umwB-5lunA:
12.50
5umwE-5lunA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6v AMYLOSUCRASE

(Neisseria
polysaccharea) 		no annotation 4 ARG A 524
TYR A 535
GLU A 124
LEU A 486
 None
 1.02A 5umwB-5n6vA:
undetectable
5umwE-5n6vA:
undetectable		 5umwB-5n6vA:
23.60
5umwE-5n6vA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t12 PHOSPHOENOLPYRUVATE-
-PROTEIN
PHOSPHOTRANSFERASE

(Escherichia
coli) 		PF00391
(PEP-utilizers)
PF05524
(PEP-utilisers_N) 		4 VAL A 262
ARG A 211
GLU A 208
LEU A 306
 None
 1.07A 5umwB-5t12A:
undetectable
5umwE-5t12A:
undetectable		 5umwB-5t12A:
14.75
5umwE-5t12A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3s FAB 35022 HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL D  18
ARG D  38
TYR D  90
LEU D  59
 None
 0.92A 5umwB-5t3sD:
undetectable
5umwE-5t3sD:
undetectable		 5umwB-5t3sD:
15.16
5umwE-5t3sD:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlh LBACAS13A H328A
(C2C2)

(Lachnospiraceae
bacterium
NK4A179) 		no annotation 4 ARG A 908
TYR A 904
GLU A 628
LEU A 510
 None
 0.77A 5umwB-5wlhA:
undetectable
5umwE-5wlhA:
undetectable		 5umwB-5wlhA:
4.30
5umwE-5wlhA:
4.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xrf SNAKE VENOM SERINE
PROTEASE DA-36

(Deinagkistrodon
acutus) 		no annotation 4 VAL A 114
ARG A  71
GLU A  97
ARG A 101
 None
 1.02A 5umwB-5xrfA:
undetectable
5umwE-5xrfA:
undetectable		 5umwB-5xrfA:
20.69
5umwE-5xrfA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bb9 4-AMINO-4-DEOXYCHORI
SMATE LYASE

(Salmonella
enterica) 		no annotation 4 VAL A 171
ARG A 227
TYR A 247
GLU A 223
 None
 1.12A 5umwB-6bb9A:
undetectable
5umwE-6bb9A:
undetectable		 5umwB-6bb9A:
17.83
5umwE-6bb9A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 4 VAL A2242
TYR A2426
LEU A2404
ARG A2216
 None
 1.11A 5umwB-6fb3A:
undetectable
5umwE-6fb3A:
2.2		 5umwB-6fb3A:
21.43
5umwE-6fb3A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gk6 -

(-) 		no annotation 4 ARG A 121
GLU A 156
LEU A 129
ARG A 165
 None
 0.94A 5umwB-6gk6A:
undetectable
5umwE-6gk6A:
undetectable		 5umwB-6gk6A:
undetectable
5umwE-6gk6A:
undetectable