SIMILAR PATTERNS OF AMINO ACIDS FOR 5UL4_A_SAMA803_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)

(Malus domestica) 		PF00155
(Aminotran_1_2) 		5 ALA A  46
PHE A 360
GLY A 358
GLY A 205
LEU A 196
 None
 1.17A 5ul4A-1b8gA:
2.6		 5ul4A-1b8gA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 PHE A 292
ALA A 223
GLY A 231
GLY A 235
LEU A 294
 None
 1.04A 5ul4A-1ebvA:
undetectable		 5ul4A-1ebvA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h81 POLYAMINE OXIDASE

(Zea mays) 		PF01593
(Amino_oxidase) 		5 ARG A  22
GLY A 447
GLY A 429
GLU A  35
LEU A 231
 None
None
FAD  A 579 (-3.1A)
FAD  A 579 (-2.7A)
None
 1.21A 5ul4A-1h81A:
undetectable		 5ul4A-1h81A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)

(Homo sapiens) 		PF00012
(HSP70) 		5 PHE A 233
GLY A 201
GLY A 339
ILE A 343
LEU A 237
 None
ADP  A 383 (-3.6A)
ADP  A 383 (-3.2A)
ADP  A 383 ( 4.9A)
None
 1.03A 5ul4A-1hjoA:
undetectable		 5ul4A-1hjoA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktw IOTA-CARRAGEENASE

(Alteromonas sp.
ATCC 43554) 		PF12708
(Pectate_lyase_3) 		5 PHE A  94
GLY A  59
GLY A  90
ILE A  87
LEU A 126
 None
CA  A   7 ( 4.9A)
None
None
None
 1.14A 5ul4A-1ktwA:
undetectable		 5ul4A-1ktwA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus;
Bos taurus) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C) 		5 ALA E 957
ARG A 177
GLY A 175
GLY A 154
GLU A 149
 None
 1.07A 5ul4A-1o7dE:
undetectable		 5ul4A-1o7dE:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1orf GRANZYME A

(Homo sapiens) 		PF00089
(Trypsin) 		5 ARG A 156
GLY A 142
LYS A  16
GLY A 193
LEU A 200
 None
None
None
0G6  A   1 (-3.6A)
None
 1.15A 5ul4A-1orfA:
undetectable		 5ul4A-1orfA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4e GALACTOKINASE

(Pyrococcus
furiosus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		5 ALA A 297
GLY A 264
ILE A  15
GLU A  17
LEU A 274
 None
None
None
GLA  A 500 (-3.6A)
None
 1.11A 5ul4A-1s4eA:
undetectable		 5ul4A-1s4eA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udq RIBONUCLEASE PH

(Aquifex
aeolicus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 ARG A  99
GLY A  57
GLY A 108
ILE A 150
GLU A 152
 SO4  A 911 (-4.2A)
None
None
None
None
 1.04A 5ul4A-1udqA:
undetectable		 5ul4A-1udqA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE

(Saccharomyces
cerevisiae) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 PHE A 106
ALA A 152
GLY A  13
GLY A  41
ILE A 102
 None
None
FAD  A 480 ( 4.8A)
None
None
 1.17A 5ul4A-1v59A:
undetectable		 5ul4A-1v59A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ven BETA-AMYLASE

(Bacillus cereus) 		PF00686
(CBM_20)
PF01373
(Glyco_hydro_14) 		5 GLY A 285
GLU A 164
LYS A 162
ILE A  85
LEU A 396
 None
 1.20A 5ul4A-1venA:
2.1		 5ul4A-1venA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w2d INOSITOL-TRISPHOSPHA
TE 3-KINASE A

(Homo sapiens) 		PF03770
(IPK) 		5 ARG A 433
GLY A 443
GLY A 266
ILE A 396
LEU A 275
 None
 0.89A 5ul4A-1w2dA:
undetectable		 5ul4A-1w2dA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0u HYPOTHETICAL
METHYLMALONYL-COA
DECARBOXYLASE ALPHA
SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01039
(Carboxyl_trans) 		5 PHE A 353
GLY A 329
GLY A 319
ILE A 296
MET A 292
 None
 1.16A 5ul4A-1x0uA:
2.9		 5ul4A-1x0uA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xap RETINOIC ACID
RECEPTOR BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 187
ARG A 185
PHE A 235
GLY A 320
ILE A 325
 None
 1.18A 5ul4A-1xapA:
undetectable		 5ul4A-1xapA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdk RETINOIC ACID
RECEPTOR, BETA

(Mus musculus) 		PF00104
(Hormone_recep) 		5 ALA B 187
ARG B 185
PHE B 235
GLY B 320
ILE B 325
 None
 1.11A 5ul4A-1xdkB:
undetectable		 5ul4A-1xdkB:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqs HEAT SHOCK 70 KDA
PROTEIN 1

(Homo sapiens) 		PF00012
(HSP70) 		5 PHE C 233
GLY C 201
GLY C 339
ILE C 343
LEU C 237
 None
AMP  C 401 ( 3.9A)
AMP  C 401 (-3.4A)
AMP  C 401 (-4.7A)
None
 1.20A 5ul4A-1xqsC:
undetectable		 5ul4A-1xqsC:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys2 LIPASE

(Burkholderia
cepacia) 		PF00561
(Abhydrolase_1) 		5 ALA X 163
PHE X  52
GLY X  51
GLY X 147
LEU X 287
 None
None
None
None
2HS  X 600 ( 4.8A)
 1.17A 5ul4A-1ys2X:
3.4		 5ul4A-1ys2X:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aee OROTATE
PHOSPHORIBOSYLTRANSF
ERASE

(Streptococcus
pyogenes) 		PF00156
(Pribosyltran) 		5 ALA A  74
ARG A  40
GLY A  77
GLY A  81
ILE A  83
 None
GOL  A2431 (-3.6A)
None
None
None
 1.20A 5ul4A-2aeeA:
3.7		 5ul4A-2aeeA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dej PROBABLE
GALACTOKINASE

(Pyrococcus
horikoshii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		5 ALA A 295
GLY A 262
ILE A  13
GLU A  15
LEU A 272
 None
None
None
GLA  A 401 (-3.5A)
None
 1.12A 5ul4A-2dejA:
undetectable		 5ul4A-2dejA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE

(Pyrococcus
horikoshii) 		PF02222
(ATP-grasp) 		5 ALA A  60
GLY A  31
GLY A  28
ILE A  90
LEU A  74
 None
 1.11A 5ul4A-2dwcA:
6.0		 5ul4A-2dwcA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9y ACETYL-COA
CARBOXYLASE,
CARBOXYLTRANSFERASE
ALPHA CHAIN
ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA

(Escherichia
coli;
Escherichia
coli) 		PF03255
(ACCA)
PF01039
(Carboxyl_trans) 		5 ALA B 178
GLY A 212
GLY A 214
ILE A 157
GLU A 151
 None
 1.04A 5ul4A-2f9yB:
undetectable		 5ul4A-2f9yB:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		5 ARG A  89
GLY A  85
GLY A  83
ILE A 145
LEU A  69
 None
 1.21A 5ul4A-2fk7A:
2.1		 5ul4A-2fk7A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfn GLUTAMATE RACEMASE

(Escherichia
coli) 		PF01177
(Asp_Glu_race) 		5 ALA A 134
GLY A 137
GLY A  61
ILE A  68
LEU A 100
 None
None
GLU  A1287 (-3.5A)
None
UMA  A1286 (-4.4A)
 1.02A 5ul4A-2jfnA:
2.7		 5ul4A-2jfnA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqc FILAMIN-C

(Homo sapiens) 		PF00630
(Filamin) 		5 ALA A2570
GLY A2494
GLY A2492
ILE A2507
LEU A2518
 None
None
None
None
IMD  A 201 (-4.5A)
 1.05A 5ul4A-2nqcA:
undetectable		 5ul4A-2nqcA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)

(Mycobacterium
tuberculosis) 		PF00155
(Aminotran_1_2) 		5 PHE A 374
ALA A 209
ARG A 288
GLY A 314
GLY A 173
 None
 1.16A 5ul4A-2o0rA:
2.7		 5ul4A-2o0rA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o69 IRON-UTILIZATION
PERIPLASMIC PROTEIN

(Haemophilus
influenzae) 		PF01547
(SBP_bac_1) 		5 ALA A 285
ARG A 103
GLY A 222
MET A 117
GLU A 114
 None
 1.15A 5ul4A-2o69A:
2.6		 5ul4A-2o69A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ofy PUTATIVE XRE-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF13560
(HTH_31) 		5 ARG A  13
GLY A  14
GLY A  50
ILE A  47
LEU A  69
 None
 1.11A 5ul4A-2ofyA:
undetectable		 5ul4A-2ofyA:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqc PENICILLIN V ACYLASE

(Bacillus
subtilis) 		PF02275
(CBAH) 		5 ALA A  79
GLY A  70
GLY A  56
ILE A  30
LEU A  61
 None
 1.19A 5ul4A-2oqcA:
undetectable		 5ul4A-2oqcA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqo NEUROPILIN-2

(Homo sapiens) 		PF00431
(CUB)
PF00754
(F5_F8_type_C) 		5 ALA A 581
GLY A 584
GLY A 505
ILE A 503
GLU A 550
 None
 1.00A 5ul4A-2qqoA:
undetectable		 5ul4A-2qqoA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA

(Escherichia
coli) 		PF00654
(Voltage_CLC) 		5 PHE A 348
GLY A 354
LYS A 131
GLY A 355
GLU A 113
 None
None
None
CL  A   2 ( 3.0A)
None
 1.22A 5ul4A-2r9hA:
undetectable		 5ul4A-2r9hA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr2 DIHYDROPYRIMIDINASE

(Homo sapiens) 		PF01979
(Amidohydro_1) 		5 ALA A 383
ARG A 391
GLY A  62
ILE A 403
LEU A  35
 None
 1.13A 5ul4A-2vr2A:
2.2		 5ul4A-2vr2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfx HEDGEHOG-INTERACTING
PROTEIN

(Homo sapiens) 		PF07995
(GSDH) 		5 ALA B 436
GLY B 493
GLY B 512
ILE B 551
LEU B 579
 None
 1.16A 5ul4A-2wfxB:
undetectable		 5ul4A-2wfxB:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Bacillus
subtilis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 PHE A 288
GLY A 266
GLY A  91
ILE A  67
GLU A  12
 None
 1.17A 5ul4A-2xd4A:
4.8		 5ul4A-2xd4A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK

([Ruminococcus]
gnavus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		5 PHE A 280
PHE A 251
GLY A 274
GLU A 278
LEU A 279
 None
None
None
MG  A1726 ( 4.9A)
None
 1.20A 5ul4A-2yfnA:
3.0		 5ul4A-2yfnA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1

(Arabidopsis
thaliana) 		PF07859
(Abhydrolase_3) 		5 ALA A 197
PHE A 112
GLY A 162
ILE A  70
LEU A 175
 None
 1.08A 5ul4A-2zsiA:
4.1		 5ul4A-2zsiA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfn KINESIN-LIKE PROTEIN
KIF22

(Homo sapiens) 		PF00225
(Kinesin) 		5 ARG A 245
GLY A 277
GLU A 279
GLY A 127
GLU A 348
 None
 1.01A 5ul4A-3bfnA:
undetectable		 5ul4A-3bfnA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo sapiens) 		PF00069
(Pkinase) 		5 PHE A 264
ALA A 149
GLY A 214
ILE A 268
LEU A 257
 None
 1.08A 5ul4A-3dakA:
2.3		 5ul4A-3dakA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dez OROTATE
PHOSPHORIBOSYLTRANSF
ERASE

(Streptococcus
mutans) 		PF00156
(Pribosyltran) 		5 ALA A  74
ARG A  40
GLY A  77
GLY A  81
ILE A  83
 None
SO4  A 211 (-4.1A)
None
None
None
 1.14A 5ul4A-3dezA:
2.7		 5ul4A-3dezA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e60 3-OXOACYL-[ACYL-CARR
IER-PROTEIN ]
SYNTHASE II

(Bartonella
henselae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ALA A 149
ARG A 144
GLY A 116
GLY A 114
MET A 239
 None
 1.21A 5ul4A-3e60A:
undetectable		 5ul4A-3e60A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe1 HEAT SHOCK 70 KDA
PROTEIN 6

(Homo sapiens) 		PF00012
(HSP70) 		5 PHE A 235
GLY A 203
GLY A 341
ILE A 345
LEU A 239
 None
ADP  A 386 (-3.0A)
ADP  A 386 (-3.2A)
ADP  A 386 (-4.8A)
None
 1.05A 5ul4A-3fe1A:
undetectable		 5ul4A-3fe1A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpz THIAZOLE
BIOSYNTHETIC ENZYME

(Saccharomyces
cerevisiae) 		PF01946
(Thi4) 		5 ALA A 289
GLY A  77
GLY A  74
ILE A 149
LEU A 126
 None
None
AHZ  A1100 (-3.6A)
None
None
 1.05A 5ul4A-3fpzA:
undetectable		 5ul4A-3fpzA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1t TYPE I SITE-SPECIFIC
RESTRICTION-MODIFICA
TION SYSTEM, R
(RESTRICTION)
SUBUNIT

(Vibrio
vulnificus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF13588
(HSDR_N_2) 		5 PHE A 552
ALA A 206
ARG A 542
GLY A 538
ILE A 554
 None
 1.17A 5ul4A-3h1tA:
undetectable		 5ul4A-3h1tA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifc FRUCTOSE-1,6-BISPHOS
PHATASE ISOZYME 2

(Homo sapiens) 		PF00316
(FBPase) 		5 ALA A 130
GLY A 122
GLY A 133
ILE A 135
LEU A 318
 None
SO4  A 342 ( 3.0A)
None
None
None
 1.07A 5ul4A-3ifcA:
2.1		 5ul4A-3ifcA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 2

(Homo sapiens) 		PF00899
(ThiF)
PF14732
(UAE_UbL) 		5 ALA B  73
GLY B  29
ILE B 398
GLU B 138
LEU B 136
 None
 1.14A 5ul4A-3kydB:
4.1		 5ul4A-3kydB:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE II

(Brucella
melitensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ALA A 149
ARG A 144
GLY A 116
GLY A 114
MET A 239
 None
 1.22A 5ul4A-3kzuA:
undetectable		 5ul4A-3kzuA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0o TRANSCRIPTION
TERMINATION FACTOR
RHO

(Thermotoga
maritima) 		PF00006
(ATP-synt_ab)
PF07497
(Rho_RNA_bind)
PF07498
(Rho_N) 		5 PHE A  57
GLY A  58
GLY A 106
ILE A 104
LEU A 257
 None
 1.12A 5ul4A-3l0oA:
undetectable		 5ul4A-3l0oA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4i HEAT SHOCK 70
(HSP70) PROTEIN

(Cryptosporidium
parvum) 		PF00012
(HSP70) 		5 PHE A 249
GLY A 217
GLY A 356
ILE A 360
LEU A 253
 None
ADP  A 401 (-3.4A)
ADP  A 401 (-3.2A)
ADP  A 401 ( 4.9A)
None
 1.06A 5ul4A-3l4iA:
2.1		 5ul4A-3l4iA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmb UNCHARACTERIZED
PROTEIN

(Oleispira
antarctica) 		PF09500
(YiiD_C) 		5 ALA A 134
PHE A 155
GLY A 157
GLY A  91
LEU A  22
 None
 0.98A 5ul4A-3lmbA:
2.2		 5ul4A-3lmbA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mil ISOAMYL
ACETATE-HYDROLYZING
ESTERASE

(Saccharomyces
cerevisiae) 		PF13472
(Lipase_GDSL_2) 		5 PHE A  79
ALA A 172
PHE A 173
GLY A 122
LEU A   8
 None
 0.97A 5ul4A-3milA:
5.2		 5ul4A-3milA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moy PROBABLE ENOYL-COA
HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		5 ALA A  64
GLY A 109
GLU A 133
ILE A 138
LEU A  85
 None
EDO  A 263 (-3.3A)
EDO  A 262 (-3.5A)
None
None
 1.21A 5ul4A-3moyA:
2.1		 5ul4A-3moyA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvq SEMAPHORIN-7A

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI)
PF13895
(Ig_2) 		5 ALA A 106
GLU A 102
GLY A 103
GLU A 494
LEU A 492
 None
 1.20A 5ul4A-3nvqA:
undetectable		 5ul4A-3nvqA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxg NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB

(Bacillus
subtilis) 		PF00004
(AAA)
PF02151
(UVR)
PF02861
(Clp_N) 		5 ALA A  49
GLY A  44
GLU A  41
GLY A  42
GLU A  20
 None
 1.20A 5ul4A-3pxgA:
undetectable		 5ul4A-3pxgA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxi NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB

(Bacillus
subtilis) 		PF00004
(AAA)
PF02151
(UVR)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 ALA A  49
GLY A  44
GLU A  41
GLY A  42
GLU A  20
 None
 1.20A 5ul4A-3pxiA:
undetectable		 5ul4A-3pxiA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3saj GLUTAMATE RECEPTOR 1

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		5 PHE A  13
GLY A  69
GLY A  11
ILE A   9
LEU A  31
 None
 1.19A 5ul4A-3sajA:
7.6		 5ul4A-3sajA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A

(Homo sapiens) 		PF00149
(Metallophos)
PF04152
(Mre11_DNA_bind) 		5 ARG A 155
PHE A 153
GLY A 154
GLY A 180
ILE A 216
 None
 1.11A 5ul4A-3t1iA:
3.2		 5ul4A-3t1iA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw0 PECTINESTERASE

(Yersinia
enterocolitica) 		PF01095
(Pectinesterase) 		5 ARG A  85
GLY A  87
GLY A  65
GLU A  69
LEU A  71
 None
 1.02A 5ul4A-3uw0A:
undetectable		 5ul4A-3uw0A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bju N-ACETYLGLUCOSAMINE-
PHOSPHATE MUTASE

(Aspergillus
fumigatus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		5 ALA A 310
ARG A 308
GLY A 306
GLY A 383
LEU A 212
 None
 1.19A 5ul4A-4bjuA:
undetectable		 5ul4A-4bjuA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fso PROBABLE PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		5 PHE A 111
ARG A 154
GLY A 137
GLY A 114
MET A 104
 C8E  A 508 (-4.5A)
None
None
None
C8E  A 508 (-4.2A)
 1.18A 5ul4A-4fsoA:
undetectable		 5ul4A-4fsoA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fx5 VON WILLEBRAND
FACTOR TYPE A

(Catenulispora
acidiphila) 		PF13768
(VWA_3) 		5 ALA A  34
GLY A 287
GLY A 235
ILE A 156
GLU A  53
 None
 1.15A 5ul4A-4fx5A:
4.1		 5ul4A-4fx5A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im4 ENDOGLUCANASE E

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase) 		5 PHE A 188
ARG A 178
GLY A 229
ILE A 225
LEU A 187
 None
 1.19A 5ul4A-4im4A:
2.6		 5ul4A-4im4A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN

(Homo sapiens;
Rattus
norvegicus) 		PF00012
(HSP70) 		5 PHE A 233
GLY A 201
GLY A 339
ILE A 343
LEU A 237
 None
ADP  A 601 (-2.9A)
ADP  A 601 (-3.2A)
None
None
 1.01A 5ul4A-4j8fA:
2.4		 5ul4A-4j8fA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jl0 REGULATORY PROTEIN
PCRH

(Pseudomonas
aeruginosa) 		PF07720
(TPR_3) 		5 PHE A 106
ARG A  71
GLY A  75
GLY A  77
LEU A  98
 None
 1.02A 5ul4A-4jl0A:
undetectable		 5ul4A-4jl0A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1

(Rattus
norvegicus) 		PF00245
(Alk_phosphatase) 		5 PHE A 309
ALA A 337
PHE A 334
GLY A 312
GLY A  41
 None
 1.20A 5ul4A-4kjdA:
undetectable		 5ul4A-4kjdA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldn PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Aliivibrio
fischeri) 		PF01048
(PNP_UDP_1) 		5 PHE A  74
ALA A  26
GLY A  21
GLY A  64
GLU A  76
 None
None
PO4  A 301 (-3.4A)
EDO  A 306 ( 4.8A)
None
 1.07A 5ul4A-4ldnA:
undetectable		 5ul4A-4ldnA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nge PRESEQUENCE
PROTEASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		5 PHE D 688
ALA D 580
GLY D 775
GLY D 804
GLU D 686
 None
 1.10A 5ul4A-4ngeD:
undetectable		 5ul4A-4ngeD:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nq3 CYANURIC ACID
AMIDOHYDROLASE

(Azorhizobium
caulinodans) 		PF09663
(Amido_AtzD_TrzD) 		5 ALA A 223
GLY A 336
GLU A 337
GLY A 335
LEU A 122
 None
MG  A 409 (-3.9A)
None
None
None
 1.20A 5ul4A-4nq3A:
undetectable		 5ul4A-4nq3A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A

(Staphylococcus
aureus) 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		5 PHE B1022
ALA B1034
GLY B1178
MET B 622
LEU B 519
 None
 1.21A 5ul4A-4plbB:
4.5		 5ul4A-4plbB:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 PHE A2659
GLY A2660
GLY A2737
GLU A2776
LEU A2742
 None
 1.20A 5ul4A-4qyrA:
undetectable		 5ul4A-4qyrA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE

(Methylovorus
sp. MP688) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 ALA A  16
GLY A  13
GLU A  36
GLY A  12
LEU A  71
 FAD  A 700 (-3.3A)
FAD  A 700 ( 4.8A)
FAD  A 700 (-2.7A)
FAD  A 700 (-3.2A)
None
 1.19A 5ul4A-4udrA:
2.4		 5ul4A-4udrA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyu PROTEIN SCRIBBLE
HOMOLOG

(Homo sapiens) 		PF00595
(PDZ) 		5 ALA A  79
ARG A  77
GLY A  45
GLY A  30
LEU A  62
 None
 1.11A 5ul4A-4wyuA:
undetectable		 5ul4A-4wyuA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y81 PROTEASOME SUBUNIT
BETA TYPE-6

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		5 ARG L 137
GLY L 140
GLY L  10
GLU L 203
LEU L 205
 None
 1.09A 5ul4A-4y81L:
undetectable		 5ul4A-4y81L:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwl BETAINE-ALDEHYDE
DEHYDROGENASE

(Staphylococcus
aureus) 		PF00171
(Aldedh) 		5 ALA A 291
GLY A 258
GLY A 257
GLU A 467
LEU A 468
 None
None
NAD  A 501 (-2.9A)
None
None
 1.21A 5ul4A-4zwlA:
3.9		 5ul4A-4zwlA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxb INSULIN RECEPTOR

(Homo sapiens) 		PF00041
(fn3)
PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		5 ALA E 636
ARG E 774
GLY E 778
ILE E 781
GLU E 782
 None
 1.18A 5ul4A-4zxbE:
2.0		 5ul4A-4zxbE:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		5 ALA A 604
ARG A 602
PHE A 588
GLY A 590
GLY A 525
 None
 1.18A 5ul4A-5a42A:
undetectable		 5ul4A-5a42A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST

(Pseudomonas
aeruginosa) 		no annotation 5 ALA A 507
GLU A1054
GLY A 479
GLU A1041
LEU A1043
 None
 0.79A 5ul4A-5b7iA:
2.2		 5ul4A-5b7iA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR

(Homo sapiens) 		PF00089
(Trypsin) 		5 PHE E  40
GLY E 142
LYS E  16
GLY E 193
ILE E 213
 None
 1.12A 5ul4A-5brrE:
undetectable		 5ul4A-5brrE:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5m CYTOTOXIC
T-LYMPHOCYTE PROTEIN
4

(Mus musculus) 		PF07686
(V-set) 		5 PHE A  52
GLY A  68
GLY A  59
GLU A  46
LEU A  37
 None
 1.09A 5ul4A-5e5mA:
undetectable		 5ul4A-5e5mA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fif CARBOXYLASE

(Deinococcus
radiodurans) 		PF01039
(Carboxyl_trans) 		5 ALA A 422
ARG A 420
PHE A 449
GLY A 447
ILE A 505
 None
 1.17A 5ul4A-5fifA:
2.5		 5ul4A-5fifA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fwx GLUTAMATE RECEPTOR 4

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		5 PHE B  12
GLY B  75
GLY B  10
ILE B   8
LEU B 285
 None
 1.06A 5ul4A-5fwxB:
7.4		 5ul4A-5fwxB:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmx CARBOXYLESTERASE

(uncultured
bacterium) 		PF00144
(Beta-lactamase) 		5 PHE A  22
ALA A 214
GLY A  33
GLY A  51
ILE A   7
 None
 1.21A 5ul4A-5gmxA:
undetectable		 5ul4A-5gmxA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h83 HETEROYOHIMBINE
SYNTHASE HYS

(Catharanthus
roseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 PHE A 224
GLY A 190
GLY A 193
ILE A 197
LEU A 221
 None
 1.21A 5ul4A-5h83A:
5.2		 5ul4A-5h83A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hf4 DISKS LARGE HOMOLOG
4

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 ALA A 370
ARG A 368
GLY A 335
GLY A 329
LEU A 353
 None
 1.07A 5ul4A-5hf4A:
undetectable		 5ul4A-5hf4A:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huc 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE (DAHP)
SYNTHASE

(Corynebacterium
glutamicum) 		PF01474
(DAHP_synth_2) 		5 PHE A 422
GLY A  94
GLY A  95
ILE A 137
LEU A 196
 None
 1.10A 5ul4A-5hucA:
2.5		 5ul4A-5hucA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huc 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE (DAHP)
SYNTHASE

(Corynebacterium
glutamicum) 		PF01474
(DAHP_synth_2) 		5 PHE A 422
GLY A  94
GLY A  95
ILE A 137
MET A 190
 None
 1.17A 5ul4A-5hucA:
2.5		 5ul4A-5hucA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I

(Geobacillus
stearothermophilus) 		PF01654
(Cyt_bd_oxida_I) 		5 PHE A 322
ALA A 294
GLY A 242
GLY A 238
LEU A 270
 None
None
HEB  A 501 (-3.4A)
HEB  A 501 (-3.5A)
None
 1.15A 5ul4A-5ir6A:
undetectable		 5ul4A-5ir6A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum) 		PF00920
(ILVD_EDD) 		5 ALA A 452
GLY A 444
GLU A 494
GLY A 447
LEU A 563
 None
 1.10A 5ul4A-5j84A:
5.5		 5ul4A-5j84A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo sapiens) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		5 ALA A 275
GLY A 296
GLY A 298
ILE A 317
LEU A 199
 None
 1.07A 5ul4A-5kznA:
4.7		 5ul4A-5kznA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Bos taurus) 		PF00361
(Proton_antipo_M)
PF01059
(Oxidored_q5_N) 		5 ALA M 300
GLY M 311
GLY M 377
ILE M 373
LEU M  68
 None
 1.16A 5ul4A-5lc5M:
undetectable		 5ul4A-5lc5M:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lii MAJOR CAPSID PROTEIN

(Staphylococcus
phage 812) 		no annotation 5 PHE P  64
ARG P 454
GLY P 177
ILE P  68
LEU P  62
 None
 1.20A 5ul4A-5liiP:
undetectable		 5ul4A-5liiP:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6u BETA-MANNOSIDASE

(Dictyoglomus
thermophilum) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		5 ALA A  23
GLY A  27
GLY A 174
ILE A  84
LEU A  79
 None
 1.12A 5ul4A-5n6uA:
2.5		 5ul4A-5n6uA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nzz TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1

(Homo sapiens) 		no annotation 5 PHE A 110
ALA A 188
GLY A 184
GLU A 269
LEU A 107
 None
 1.03A 5ul4A-5nzzA:
undetectable		 5ul4A-5nzzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oex -

(-) 		no annotation 5 PHE A 394
GLY A 351
GLY A 333
ILE A 373
LEU A 361
 None
 1.08A 5ul4A-5oexA:
undetectable		 5ul4A-5oexA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 5 ARG A  55
GLY A 158
GLU A  59
ILE A  90
LEU A  87
 None
G93  A 301 ( 4.9A)
G93  A 301 (-3.2A)
G93  A 301 ( 3.8A)
None
 1.21A 5ul4A-5u94A:
2.2		 5ul4A-5u94A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uan RETINOIC ACID
RECEPTOR BETA

(Homo sapiens) 		no annotation 5 ALA B 187
ARG B 185
PHE B 235
GLY B 320
ILE B 325
 None
 1.20A 5ul4A-5uanB:
undetectable		 5ul4A-5uanB:
19.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ul4 OXSB PROTEIN

(Bacillus
megaterium) 		PF02310
(B12-binding) 		12 PHE A 320
ALA A 397
ARG A 399
PHE A 432
GLY A 434
GLU A 436
LYS A 448
GLY A 472
ILE A 474
MET A 544
GLU A 545
LEU A 547
 SAM  A 803 (-4.5A)
SAM  A 803 (-3.4A)
None
SAM  A 803 (-3.6A)
SAM  A 803 (-3.2A)
SAM  A 803 (-2.5A)
SAM  A 803 (-3.3A)
SAM  A 803 (-3.2A)
SAM  A 803 (-4.2A)
SAM  A 803 (-3.7A)
B12  A 802 (-4.4A)
SAM  A 803 ( 4.4A)
 0.00A 5ul4A-5ul4A:
62.3		 5ul4A-5ul4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ul4 OXSB PROTEIN

(Bacillus
megaterium) 		PF02310
(B12-binding) 		5 PHE A 320
ALA A 398
GLY A 434
GLU A 436
GLY A 472
 SAM  A 803 (-4.5A)
None
SAM  A 803 (-3.2A)
SAM  A 803 (-2.5A)
SAM  A 803 (-3.2A)
 1.04A 5ul4A-5ul4A:
62.3		 5ul4A-5ul4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgw ISOASPARTYL
DIPEPTIDASE

(Colwellia
psychrerythraea) 		no annotation 5 PHE A  95
ARG A 314
GLY A 295
GLY A  76
ILE A  74
 None
 1.11A 5ul4A-5xgwA:
3.5		 5ul4A-5xgwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029

(Streptococcus
pneumoniae) 		no annotation 5 ALA A 280
GLY A 314
GLY A 316
ILE A 318
LEU A 435
 None
 1.02A 5ul4A-5xj1A:
4.1		 5ul4A-5xj1A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE

(Marinobacter
hydrocarbonoclasticus) 		no annotation 5 PHE A  11
GLY A 141
ILE A 403
GLU A  15
LEU A  12
 None
 1.08A 5ul4A-6chjA:
undetectable		 5ul4A-6chjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE

(Homo sapiens) 		no annotation 5 GLY A 438
LYS A 111
GLY A 435
GLU A  66
LEU A 156
 None
 1.03A 5ul4A-6dd3A:
2.7		 5ul4A-6dd3A:
undetectable