SIMILAR PATTERNS OF AMINO ACIDS FOR 5UIZ_B_CUB301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hq9 MLL6688 PROTEIN

(Mesorhizobium
loti) 		PF12900
(Pyridox_ox_2) 		4 HIS A  44
HIS A  95
GLN A  98
TYR A  46
 None
 1.24A 5uizB-2hq9A:
undetectable		 5uizB-2hq9A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v0o FCH DOMAIN ONLY
PROTEIN 2

(Homo sapiens) 		PF00611
(FCH) 		4 HIS A 209
HIS A 112
GLN A 108
TYR A 104
 None
 1.39A 5uizB-2v0oA:
undetectable		 5uizB-2v0oA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vtc CEL61B

(Trichoderma
reesei) 		PF03443
(Glyco_hydro_61) 		4 HIS A   1
HIS A  89
GLN A 174
TYR A 176
 NI  A1231 (-3.2A)
NI  A1231 (-3.2A)
NI  A1231 ( 4.7A)
NI  A1231 (-4.7A)
 0.99A 5uizB-2vtcA:
8.6		 5uizB-2vtcA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eja PROTEIN GH61E

(Thielavia
terrestris) 		PF03443
(Glyco_hydro_61) 		4 HIS A   1
HIS A 142
GLN A 151
TYR A 153
 MG  A 701 (-3.2A)
SO4  A4851 (-3.9A)
SO4  A4851 (-3.2A)
None
 0.98A 5uizB-3ejaA:
8.5		 5uizB-3ejaA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b5q GLYCOSIDE HYDROLASE
FAMILY 61 PROTEIN D

(Phanerochaete
chrysosporium) 		PF03443
(Glyco_hydro_61) 		4 HIS A   1
HIS A 149
GLN A 158
TYR A 160
 CU  A 221 ( 3.0A)
GOL  A 222 (-4.2A)
GOL  A 222 (-3.0A)
CU  A 221 (-4.9A)
 0.90A 5uizB-4b5qA:
8.4		 5uizB-4b5qA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7u ENDOGLUCANASE II

(Neurospora
crassa) 		PF03443
(Glyco_hydro_61) 		4 HIS A   1
HIS A  83
GLN A 164
TYR A 166
 CU  A 300 (-3.0A)
CU  A 300 (-3.1A)
CU  A 300 (-4.3A)
None
 0.89A 5uizB-4d7uA:
7.9		 5uizB-4d7uA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7u ENDOGLUCANASE II

(Neurospora
crassa) 		PF03443
(Glyco_hydro_61) 		4 HIS A   1
HIS A 155
GLN A 164
TYR A 166
 CU  A 300 (-3.0A)
None
CU  A 300 (-4.3A)
None
 1.01A 5uizB-4d7uA:
7.9		 5uizB-4d7uA:
20.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbo E7

(Thermobifida
fusca) 		PF03067
(LPMO_10) 		4 HIS A  37
HIS A 144
GLN A 211
TYR A 213
 CU  A 301 (-2.9A)
CU  A 301 (-3.4A)
CU  A 301 ( 4.7A)
None
 0.55A 5uizB-4gboA:
37.5		 5uizB-4gboA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbo E7

(Thermobifida
fusca) 		PF03067
(LPMO_10) 		4 HIS A  37
HIS A 208
GLN A 211
TYR A 213
 CU  A 301 (-2.9A)
None
CU  A 301 ( 4.7A)
None
 0.77A 5uizB-4gboA:
37.5		 5uizB-4gboA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foh POLYSACCHARIDE
MONOOXYGENASE

(Neurospora
crassa) 		PF03443
(Glyco_hydro_61) 		4 HIS A   1
HIS A  81
GLN A 162
TYR A 164
 CU  A1226 ( 3.0A)
CU  A1226 ( 3.3A)
SO4  A1227 ( 3.3A)
None
 0.84A 5uizB-5fohA:
8.7		 5uizB-5fohA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foh POLYSACCHARIDE
MONOOXYGENASE

(Neurospora
crassa) 		PF03443
(Glyco_hydro_61) 		4 HIS A   1
HIS A 153
GLN A 162
TYR A 164
 CU  A1226 ( 3.0A)
SO4  A1227 (-4.1A)
SO4  A1227 ( 3.3A)
None
 1.04A 5uizB-5fohA:
8.7		 5uizB-5fohA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nns GLYCOSYL HYDROLASE
FAMILY 61, 2 PROTEIN

(Heterobasidion
irregulare) 		no annotation 4 HIS A   1
HIS A  80
GLN A 165
TYR A 167
 CU  A 303 (-3.2A)
CU  A 303 ( 3.3A)
GOL  A 309 (-3.3A)
None
 0.81A 5uizB-5nnsA:
8.1		 5uizB-5nnsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nns GLYCOSYL HYDROLASE
FAMILY 61, 2 PROTEIN

(Heterobasidion
irregulare) 		no annotation 4 HIS A   1
HIS A 159
GLN A 165
TYR A 167
 CU  A 303 (-3.2A)
GOL  A 309 (-4.2A)
GOL  A 309 (-3.3A)
None
 0.96A 5uizB-5nnsA:
8.1		 5uizB-5nnsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no7 LYTIC POLYSACCHARIDE
MONOOXYGENASE

(Trametes
cinnabarina) 		no annotation 4 HIS A   1
HIS A  99
GLN A 174
TYR A 176
 None
 0.70A 5uizB-5no7A:
6.2		 5uizB-5no7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opf CHITIN-BINDING
DOMAIN 3 PROTEIN

(Micromonospora
aurantiaca) 		no annotation 4 HIS A  37
HIS A 144
GLN A 219
TYR A 221
 CU  A 301 (-3.0A)
CU  A 301 (-3.2A)
CU  A 301 ( 4.2A)
None
 0.61A 5uizB-5opfA:
34.0		 5uizB-5opfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opf CHITIN-BINDING
DOMAIN 3 PROTEIN

(Micromonospora
aurantiaca) 		no annotation 4 HIS A  37
HIS A 216
GLN A 219
TYR A 221
 CU  A 301 (-3.0A)
None
CU  A 301 ( 4.2A)
None
 0.80A 5uizB-5opfA:
34.0		 5uizB-5opfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tkf LYTIC POLYSACCHARIDE
MONOOXYGENASE

(Neurospora
crassa) 		PF03443
(Glyco_hydro_61) 		4 HIS A   1
HIS A  84
GLN A 166
TYR A 168
 CU  A 308 (-3.0A)
CU  A 308 (-3.1A)
CU  A 308 (-4.2A)
CU  A 308 (-4.9A)
 0.90A 5uizB-5tkfA:
8.4		 5uizB-5tkfA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tkf LYTIC POLYSACCHARIDE
MONOOXYGENASE

(Neurospora
crassa) 		PF03443
(Glyco_hydro_61) 		4 HIS A   1
HIS A 157
GLN A 166
TYR A 168
 CU  A 308 (-3.0A)
None
CU  A 308 (-4.2A)
CU  A 308 (-4.9A)
 0.97A 5uizB-5tkfA:
8.4		 5uizB-5tkfA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis) 		no annotation 4 HIS A1122
HIS A 908
GLN A 904
TYR A 928
 C  B  38 ( 3.6A)
A  B  40 ( 4.1A)
C  B  38 ( 3.8A)
None
 0.95A 5uizB-5xwyA:
undetectable		 5uizB-5xwyA:
9.75