SIMILAR PATTERNS OF AMINO ACIDS FOR 5UIH_A_8CVA201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cz3 DIHYDROFOLATE
REDUCTASE


(Thermotoga
maritima)
PF00186
(DHFR_1)
4 ALA A   8
ASP A  27
ILE A 100
THR A 121
None
0.46A 5uihA-1cz3A:
20.0
5uihA-1cz3A:
30.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dr6 DIHYDROFOLATE
REDUCTASE


(Gallus gallus)
PF00186
(DHFR_1)
4 ILE A   7
ALA A   9
TYR A 121
THR A 136
HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
None
HBI  A 198 ( 4.5A)
0.26A 5uihA-1dr6A:
19.2
5uihA-1dr6A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fnn CELL DIVISION
CONTROL PROTEIN 6


(Pyrobaculum
aerophilum)
PF09079
(Cdc6_C)
PF13401
(AAA_22)
4 ILE A  90
ALA A  88
LEU A 136
ILE A  93
None
0.85A 5uihA-1fnnA:
undetectable
5uihA-1fnnA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oaa SEPIAPTERIN
REDUCTASE


(Mus musculus)
PF00106
(adh_short)
4 ILE A  99
LEU A 245
ILE A 156
THR A 152
None
None
NAP  A 800 (-4.1A)
None
0.73A 5uihA-1oaaA:
undetectable
5uihA-1oaaA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgv TROPOMODULIN TMD-1

(Caenorhabditis
elegans)
no annotation 4 ILE A 286
ALA A 282
LEU A 310
ILE A 289
None
0.74A 5uihA-1pgvA:
undetectable
5uihA-1pgvA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzx HYPOTHETICAL PROTEIN
APC36103


(Geobacillus
stearothermophilus)
PF02645
(DegV)
4 ILE A   5
ALA A  24
LEU A 114
ILE A  85
None
0.89A 5uihA-1pzxA:
undetectable
5uihA-1pzxA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcj POKEWEED ANTIVIRAL
PROTEIN


(Phytolacca
americana)
PF00161
(RIP)
4 MET A 173
LEU A  54
ILE A 144
THR A  11
None
0.87A 5uihA-1qcjA:
undetectable
5uihA-1qcjA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3g X-LINKED
INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN-LIKE 1


(Homo sapiens)
PF01582
(TIR)
4 ILE A 510
LEU A 431
ILE A 474
THR A 478
None
0.84A 5uihA-1t3gA:
2.1
5uihA-1t3gA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u70 DIHYDROFOLATE
REDUCTASE


(Mus musculus)
PF00186
(DHFR_1)
4 ILE A   7
ALA A   9
TYR A 121
THR A 136
MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
None
MTX  A 187 (-4.4A)
0.16A 5uihA-1u70A:
18.8
5uihA-1u70A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u71 DIHYDROFOLATE
REDUCTASE


(Homo sapiens)
PF00186
(DHFR_1)
4 ILE A   7
ALA A   9
TYR A 121
THR A 136
MXA  A 187 (-4.5A)
MXA  A 187 (-3.6A)
None
MXA  A 187 (-4.3A)
0.30A 5uihA-1u71A:
19.2
5uihA-1u71A:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc4 DIOL DEHYDRASE BETA
SUBUNIT


(Klebsiella
oxytoca)
PF02288
(Dehydratase_MU)
4 ILE B 130
ALA B 117
LEU B 153
ILE B 132
None
None
CNC  B2601 (-4.0A)
None
0.83A 5uihA-1uc4B:
undetectable
5uihA-1uc4B:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens)
PF00704
(Glyco_hydro_18)
4 ALA A 183
ASP A 136
LEU A  93
TYR A 212
None
0.87A 5uihA-1wb0A:
undetectable
5uihA-1wb0A:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yco BRANCHED-CHAIN
PHOSPHOTRANSACYLASE


(Enterococcus
faecalis)
PF01515
(PTA_PTB)
4 ALA A 194
LEU A 116
ILE A 151
THR A 195
None
0.89A 5uihA-1ycoA:
undetectable
5uihA-1ycoA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE


(Spinacia
oleracea)
PF01450
(IlvC)
PF07991
(IlvN)
4 ILE I 364
ALA I 497
LEU I 471
ILE I 360
None
0.85A 5uihA-1yveI:
undetectable
5uihA-1yveI:
9.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zdr DIHYDROFOLATE
REDUCTASE


(Geobacillus
stearothermophilus)
PF00186
(DHFR_1)
6 ILE A   5
ALA A   7
ASP A  27
LEU A  28
ILE A  96
THR A 115
None
None
None
SO4  A3486 ( 4.8A)
None
None
0.32A 5uihA-1zdrA:
23.4
5uihA-1zdrA:
31.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2blb DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE


(Plasmodium
vivax)
PF00186
(DHFR_1)
6 ILE A  13
ALA A  15
ASP A  53
ILE A 173
TYR A 179
THR A 194
CP7  A1240 (-4.1A)
CP7  A1240 (-3.7A)
CP7  A1240 (-3.1A)
CP7  A1240 ( 3.8A)
None
CP7  A1240 (-4.1A)
0.31A 5uihA-2blbA:
19.0
5uihA-2blbA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cun PHOSPHOGLYCERATE
KINASE


(Pyrococcus
horikoshii)
PF00162
(PGK)
4 ILE A 193
ALA A 217
LEU A 196
ILE A 322
None
0.91A 5uihA-2cunA:
undetectable
5uihA-2cunA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A


(Archaeoglobus
fulgidus)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
4 ILE A  25
ALA A 207
LEU A 434
ILE A  27
None
0.81A 5uihA-2fjaA:
undetectable
5uihA-2fjaA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE


(Trypanosoma
cruzi)
PF00186
(DHFR_1)
PF00303
(Thymidylat_synt)
5 ALA A  28
ASP A  48
ILE A 154
TYR A 160
THR A 178
NAP  A 523 (-3.7A)
None
None
None
None
0.32A 5uihA-2h2qA:
18.2
5uihA-2h2qA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR


(Cryptosporidium
hominis)
PF00186
(DHFR_1)
PF00303
(Thymidylat_synt)
5 ALA A  11
ASP A  32
LEU A  33
TYR A 119
THR A 134
MTX  A 605 ( 3.6A)
MTX  A 605 ( 3.0A)
MTX  A 605 ( 4.0A)
None
MTX  A 605 ( 4.2A)
0.51A 5uihA-2oipA:
19.6
5uihA-2oipA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4g HYPOTHETICAL PROTEIN

(Corynebacterium
diphtheriae)
PF01872
(RibD_C)
4 ILE A  38
ASP A  61
TYR A 199
THR A 214
EDO  A 278 (-4.7A)
EDO  A 278 (-3.2A)
EDO  A 280 (-4.3A)
None
0.43A 5uihA-2p4gA:
15.2
5uihA-2p4gA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4g HYPOTHETICAL PROTEIN

(Corynebacterium
diphtheriae)
PF01872
(RibD_C)
4 ILE A 190
ALA A  72
LEU A 111
ILE A 192
None
0.85A 5uihA-2p4gA:
15.2
5uihA-2p4gA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfv EXOCYST COMPLEX
COMPONENT EXO70


(Saccharomyces
cerevisiae)
PF03081
(Exo70)
4 ILE A 352
ALA A 371
ILE A 353
THR A 372
None
0.83A 5uihA-2pfvA:
undetectable
5uihA-2pfvA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pv7 T-PROTEIN [INCLUDES:
CHORISMATE MUTASE
(EC 5.4.99.5) (CM)
AND PREPHENATE
DEHYDROGENASE (EC
1.3.1.12) (PDH)]


(Haemophilus
influenzae)
PF02153
(PDH)
4 ILE A 103
ALA A 145
LEU A 174
ILE A 105
None
0.76A 5uihA-2pv7A:
undetectable
5uihA-2pv7A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qi9 VITAMIN B12 IMPORT
SYSTEM PERMEASE
PROTEIN BTUC


(Escherichia
coli)
PF01032
(FecCD)
4 ILE A 256
ALA A  68
LEU A 288
ILE A 253
None
0.85A 5uihA-2qi9A:
undetectable
5uihA-2qi9A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk8 DIHYDROFOLATE
REDUCTASE


(Bacillus
anthracis)
PF00186
(DHFR_1)
4 ALA A   8
LEU A  29
TYR A 102
THR A 115
MTX  A 200 ( 3.4A)
MTX  A 200 ( 4.3A)
None
MTX  A 200 ( 4.4A)
0.48A 5uihA-2qk8A:
23.6
5uihA-2qk8A:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzf NAPHTHOATE SYNTHASE

(Staphylococcus
aureus)
PF00378
(ECH_1)
4 ILE A 105
ALA A 222
ASP A 240
ILE A 106
None
0.78A 5uihA-2uzfA:
undetectable
5uihA-2uzfA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2va1 URIDYLATE KINASE

(Ureaplasma
parvum)
PF00696
(AA_kinase)
4 ILE A   6
ALA A 146
LEU A 209
ILE A   8
None
0.74A 5uihA-2va1A:
undetectable
5uihA-2va1A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3w DIHYDROFOLATE
REDUCTASE


(Mycobacterium
avium)
PF00186
(DHFR_1)
6 ALA A  11
ASP A  31
LEU A  32
ILE A 102
TYR A 108
THR A 121
VG9  A1168 ( 3.8A)
VG9  A1168 (-3.0A)
VG9  A1168 (-4.7A)
VG9  A1168 ( 4.2A)
None
VG9  A1168 ( 4.7A)
0.39A 5uihA-2w3wA:
23.2
5uihA-2w3wA:
26.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9s DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003


(Staphylococcus
aureus)
PF00186
(DHFR_1)
6 ILE A   5
ALA A   7
ASP A  27
LEU A  28
TYR A  98
THR A 111
TOP  A1160 (-4.2A)
TOP  A1160 ( 3.6A)
TOP  A1160 (-2.8A)
TOP  A1160 ( 4.6A)
None
TOP  A1160 ( 4.5A)
0.35A 5uihA-2w9sA:
24.0
5uihA-2w9sA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wae PENICILLIN-BINDING
PROTEIN 2B


(Streptococcus
pneumoniae)
PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
4 ILE A 308
ASP A 494
LEU A 495
ILE A  63
None
0.90A 5uihA-2waeA:
undetectable
5uihA-2waeA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus)
PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110)
4 ILE A 612
ALA A 605
ASP A 553
ILE A  95
None
0.89A 5uihA-2xvgA:
undetectable
5uihA-2xvgA:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5q PUTATIVE SULFATASE
YIDJ


(Bacteroides
thetaiotaomicron)
PF00884
(Sulfatase)
PF16347
(DUF4976)
5 ALA A  57
LEU A 334
ILE A 310
TYR A  34
THR A 328
None
None
None
None
EDO  A 503 (-4.0A)
1.14A 5uihA-3b5qA:
undetectable
5uihA-3b5qA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfr DIHYDROFOLATE
REDUCTASE


(Lactobacillus
casei)
PF00186
(DHFR_1)
4 ALA A   6
ASP A  26
LEU A  27
THR A 116
MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.3A)
0.33A 5uihA-3dfrA:
22.0
5uihA-3dfrA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dg8 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE


(Plasmodium
falciparum)
PF00186
(DHFR_1)
5 ILE A  14
ALA A  16
ASP A  54
TYR A 170
THR A 185
RJ6  A 609 (-4.5A)
RJ6  A 609 (-3.7A)
RJ6  A 609 (-3.0A)
NDP  A 610 ( 4.9A)
RJ6  A 609 ( 4.5A)
0.21A 5uihA-3dg8A:
19.1
5uihA-3dg8A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxi PUTATIVE ALDOLASE

(Bacteroides
vulgatus)
PF00682
(HMGL-like)
4 ILE A 154
ALA A 120
ILE A 115
THR A 123
None
0.85A 5uihA-3dxiA:
undetectable
5uihA-3dxiA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8a DIHYDROFOLATE
REDUCTASE


(Staphylococcus
aureus)
PF00186
(DHFR_1)
5 ALA X   7
ASP X  27
LEU X  28
TYR X  98
THR X 111
N22  X 219 ( 3.6A)
N22  X 219 (-2.8A)
N22  X 219 (-4.4A)
None
N22  X 219 (-4.4A)
0.42A 5uihA-3i8aX:
24.0
5uihA-3i8aX:
29.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ia4 DIHYDROFOLATE
REDUCTASE


(Moritella
profunda)
PF00186
(DHFR_1)
6 ILE A   6
ALA A   8
LEU A  29
ILE A  96
TYR A 102
THR A 115
MTX  A 164 (-4.0A)
MTX  A 164 ( 3.7A)
MTX  A 164 (-4.0A)
MTX  A 164 ( 4.2A)
None
MTX  A 164 (-4.3A)
0.55A 5uihA-3ia4A:
25.9
5uihA-3ia4A:
34.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ian CHITINASE

(Lactococcus
lactis)
PF00704
(Glyco_hydro_18)
4 ALA A 198
ASP A 158
LEU A 121
TYR A 229
EDO  A 361 ( 4.7A)
None
None
EDO  A 361 (-4.5A)
0.87A 5uihA-3ianA:
undetectable
5uihA-3ianA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihv SUSD HOMOLOG

(Bacteroides
thetaiotaomicron)
PF07980
(SusD_RagB)
PF14322
(SusD-like_3)
4 ILE A 120
ALA A  39
LEU A 137
ILE A 124
None
0.82A 5uihA-3ihvA:
undetectable
5uihA-3ihvA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuo ATP-DEPENDENT DNA
HELICASE RECQ


(Porphyromonas
gingivalis)
no annotation 4 ILE A 628
ALA A 642
LEU A 653
ILE A 632
None
0.77A 5uihA-3iuoA:
undetectable
5uihA-3iuoA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ix9 DIHYDROFOLATE
REDUCTASE


(Streptococcus
pneumoniae)
PF00186
(DHFR_1)
4 ILE A   8
ALA A  10
LEU A  31
THR A 119
MTX  A 200 (-4.1A)
MTX  A 200 (-3.8A)
MTX  A 200 ( 4.1A)
MTX  A 200 ( 4.5A)
0.32A 5uihA-3ix9A:
23.0
5uihA-3ix9A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jck 26S PROTEASOME
REGULATORY SUBUNIT
RPN3


(Saccharomyces
cerevisiae)
PF01399
(PCI)
PF08375
(Rpn3_C)
4 ILE A 293
ALA A 270
LEU A 310
ILE A 294
None
0.89A 5uihA-3jckA:
undetectable
5uihA-3jckA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE


(Babesia bovis)
PF00186
(DHFR_1)
PF00303
(Thymidylat_synt)
4 ALA A  16
ASP A  37
TYR A 129
THR A 144
NAP  A 512 (-3.7A)
None
None
None
0.19A 5uihA-3kjrA:
19.4
5uihA-3kjrA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9x GLUTATHIONE-REGULATE
D POTASSIUM-EFFLUX
SYSTEM PROTEIN KEFC,
LINKER, ANCILLARY
PROTEIN KEFF


(Escherichia
coli)
PF02254
(TrkA_N)
PF02525
(Flavodoxin_2)
4 ILE A1002
ALA A1056
LEU A1100
ILE A1004
None
0.85A 5uihA-3l9xA:
2.2
5uihA-3l9xA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5


(Homo sapiens)
PF01094
(ANF_receptor)
4 ILE A  37
ALA A  39
LEU A  73
ILE A  36
None
0.77A 5uihA-3lmkA:
3.3
5uihA-3lmkA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnl UPF0135 PROTEIN
SA1388


(Staphylococcus
aureus)
PF01784
(NIF3)
4 ILE A 283
ALA A 302
LEU A 325
ILE A 285
None
0.84A 5uihA-3lnlA:
undetectable
5uihA-3lnlA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oet ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE


(Salmonella
enterica)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410)
4 ILE A 119
ALA A 168
LEU A 203
ILE A 121
None
0.92A 5uihA-3oetA:
undetectable
5uihA-3oetA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvz UDP-N-ACETYLGLUCOSAM
INE 4,6-DEHYDRATASE


(Aliivibrio
fischeri)
PF02719
(Polysacc_synt_2)
4 ILE A 270
ALA A 201
LEU A   5
ILE A 265
None
SCN  A 604 ( 4.9A)
None
None
0.71A 5uihA-3pvzA:
undetectable
5uihA-3pvzA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg9 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE


(Trypanosoma
brucei)
PF00186
(DHFR_1)
5 ALA A  34
ASP A  54
ILE A 160
TYR A 166
THR A 184
WRA  A 602 (-3.9A)
WRA  A 602 (-2.9A)
WRA  A 602 ( 3.9A)
None
WRA  A 602 (-4.2A)
0.27A 5uihA-3rg9A:
18.3
5uihA-3rg9A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sob LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6


(Homo sapiens)
PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition)
4 ALA B 101
MET B 152
LEU B 187
ILE B 119
None
0.90A 5uihA-3sobB:
undetectable
5uihA-3sobB:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t3c HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
4 ILE A  85
ALA A  28
LEU A  76
ILE A  89
None
017  A 201 (-3.5A)
None
None
0.75A 5uihA-3t3cA:
undetectable
5uihA-3t3cA:
21.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tq9 DIHYDROFOLATE
REDUCTASE


(Coxiella
burnetii)
PF00186
(DHFR_1)
6 ILE A   6
ALA A   8
ASP A  28
LEU A  29
ILE A  96
THR A 115
MTX  A2001 (-4.0A)
MTX  A2001 ( 3.4A)
MTX  A2001 (-2.7A)
MTX  A2001 (-3.9A)
MTX  A2001 ( 4.2A)
MTX  A2001 (-4.3A)
0.40A 5uihA-3tq9A:
23.8
5uihA-3tq9A:
32.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u02 PUTATIVE
TRANSCRIPTION-ASSOCI
ATED PROTEIN TFIIS


(Pyrococcus
furiosus)
PF08489
(DUF1743)
4 ILE A   3
ALA A  33
LEU A  75
ILE A  69
None
0.84A 5uihA-3u02A:
undetectable
5uihA-3u02A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u3g RIBONUCLEASE H

(uncultured
organism)
no annotation 4 ILE D  25
LEU D  57
ILE D   4
THR D   8
None
0.76A 5uihA-3u3gD:
undetectable
5uihA-3u3gD:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE


(Plasmodium
falciparum)
PF00186
(DHFR_1)
PF00303
(Thymidylat_synt)
5 ILE A  14
ASP A  54
ILE A 164
TYR A 170
THR A 185
1CY  A 609 (-4.3A)
1CY  A 609 (-2.9A)
1CY  A 609 ( 4.0A)
None
1CY  A 609 (-4.3A)
0.25A 5uihA-3um6A:
19.1
5uihA-3um6A:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vco DIHYDROFOLATE
REDUCTASE


(Schistosoma
mansoni)
PF00186
(DHFR_1)
5 ALA A   8
ASP A  28
ILE A 111
TYR A 117
THR A 133
None
0.47A 5uihA-3vcoA:
18.8
5uihA-3vcoA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zcw KINESIN-LIKE PROTEIN
KIF11


(Homo sapiens)
PF00225
(Kinesin)
4 ILE A  19
LEU A 320
ILE A 332
THR A 328
None
None
4A2  A1366 (-3.9A)
None
0.66A 5uihA-3zcwA:
undetectable
5uihA-3zcwA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5o BIFUNCTIONAL PROTEIN
FOLD


(Pseudomonas
aeruginosa)
PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C)
4 ILE A 226
ALA A 253
LEU A   5
ILE A 228
None
0.88A 5uihA-4a5oA:
undetectable
5uihA-4a5oA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axn CHITINASE C1

(Serratia
marcescens)
PF00704
(Glyco_hydro_18)
4 ALA A 177
ASP A 137
LEU A 100
TYR A 208
ACT  A1331 ( 3.9A)
None
None
ACT  A1331 (-4.6A)
0.81A 5uihA-4axnA:
undetectable
5uihA-4axnA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SEC23P

(Saccharomyces
cerevisiae)
PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS)
4 ILE A 490
LEU A  65
ILE A 502
THR A 506
None
0.80A 5uihA-4bziA:
undetectable
5uihA-4bziA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3y DIHYDRODIPICOLINATE
REDUCTASE


(Burkholderia
thailandensis)
PF01113
(DapB_N)
PF05173
(DapB_C)
4 ILE A   6
ALA A  70
LEU A  96
ILE A   8
None
0.81A 5uihA-4f3yA:
2.0
5uihA-4f3yA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE


(Homo sapiens)
PF00884
(Sulfatase)
PF14707
(Sulfatase_C)
4 ILE A 265
MET A  41
LEU A  37
ILE A 261
None
0.90A 5uihA-4fdjA:
undetectable
5uihA-4fdjA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flc ADENYLOSUCCINATE
LYASE


(Homo sapiens)
PF00206
(Lyase_1)
PF10397
(ADSL_C)
4 ILE A 237
ALA A 235
ASP A 223
ILE A 238
None
0.85A 5uihA-4flcA:
undetectable
5uihA-4flcA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g8z DIHYDROFOLATE
REDUCTASE


(Pneumocystis
jirovecii)
PF00186
(DHFR_1)
5 ILE X  10
ALA X  12
ILE X 123
TYR X 129
THR X 144
TOP  X 301 (-4.2A)
NDP  X 302 ( 3.8A)
TOP  X 301 ( 4.0A)
None
TOP  X 301 (-4.5A)
0.23A 5uihA-4g8zX:
18.7
5uihA-4g8zX:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h96 DIHYDROFOLATE
REDUCTASE


(Candida
albicans)
PF00186
(DHFR_1)
5 ILE A   9
ALA A  11
ILE A 112
TYR A 118
THR A 133
14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
0.30A 5uihA-4h96A:
16.5
5uihA-4h96A:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h98 DIHYDROFOLATE
REDUCTASE


([Candida]
glabrata)
PF00186
(DHFR_1)
5 ILE A   9
ALA A  11
ILE A 121
TYR A 127
THR A 140
14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
0.20A 5uihA-4h98A:
17.0
5uihA-4h98A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha6 PYRIDOXINE 4-OXIDASE

(Mesorhizobium
loti)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
4 ILE A  20
ALA A 260
LEU A 489
ILE A  22
None
0.81A 5uihA-4ha6A:
undetectable
5uihA-4ha6A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7h PEROXIDE STRESS
SENSING REGULATOR


(Streptococcus
pyogenes)
PF01475
(FUR)
4 ILE A  39
ASP A  11
LEU A  10
ILE A  35
None
0.91A 5uihA-4i7hA:
undetectable
5uihA-4i7hA:
18.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4m2x DIHYDROFOLATE
REDUCTASE


(Mycobacterium
tuberculosis)
PF00186
(DHFR_1)
6 ILE A   5
ALA A   7
ASP A  27
ILE A  94
TYR A 100
THR A 113
TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
0.25A 5uihA-4m2xA:
21.6
5uihA-4m2xA:
30.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7v DIHYDROFOLATE
REDUCTASE


(Enterococcus
faecalis)
PF00186
(DHFR_1)
5 ILE A   5
ALA A   7
ASP A  27
LEU A  28
THR A 116
RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.4A)
0.46A 5uihA-4m7vA:
23.3
5uihA-4m7vA:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6g UNCHARACTERIZED
PROTEIN


(Mycobacterium
tuberculosis)
PF15598
(Imm61)
4 ILE A  56
ALA A  71
MET A  74
ILE A  47
None
0.85A 5uihA-4o6gA:
undetectable
5uihA-4o6gA:
24.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p68 DIHYDROFOLATE
REDUCTASE


(Escherichia
coli)
PF00186
(DHFR_1)
6 ILE A   5
ALA A   7
ASP A  27
ILE A  94
TYR A 100
THR A 113
MTX  A 201 (-4.1A)
MTX  A 201 ( 4.0A)
MTX  A 201 (-3.0A)
MTX  A 201 ( 4.3A)
None
MTX  A 201 ( 4.5A)
0.19A 5uihA-4p68A:
27.9
5uihA-4p68A:
98.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q66 PROTEIN BCH1

(Saccharomyces
cerevisiae)
no annotation 4 ALA K 403
LEU K 484
ILE K 490
THR K 391
None
0.85A 5uihA-4q66K:
undetectable
5uihA-4q66K:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4toq CLASS III CHITINASE

(Punica granatum)
PF00704
(Glyco_hydro_18)
4 ALA A 156
ASP A 123
LEU A  75
TYR A 183
None
0.84A 5uihA-4toqA:
undetectable
5uihA-4toqA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uri CHITINASE-RELATED
AGGLUTININ


(Robinia
pseudoacacia)
PF00704
(Glyco_hydro_18)
4 ALA A 155
ASP A 112
LEU A  67
TYR A 185
MPD  A 401 (-3.4A)
None
None
MPD  A 401 (-4.8A)
0.84A 5uihA-4uriA:
undetectable
5uihA-4uriA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usq PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE


(Cellvibrio sp.
BR)
PF13738
(Pyr_redox_3)
4 ILE A  16
ALA A 130
LEU A 324
ILE A  18
None
0.90A 5uihA-4usqA:
undetectable
5uihA-4usqA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5u CHITINASE

(Streptomyces
thermoviolaceus)
no annotation 4 ALA B 219
ASP B 179
LEU B 136
TYR B 250
None
0.89A 5uihA-4w5uB:
undetectable
5uihA-4w5uB:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5z CHITINASE 60

(Moritella
marina)
PF00704
(Glyco_hydro_18)
4 ALA A 189
ASP A 149
LEU A 112
TYR A 220
ACT  A 404 ( 3.1A)
None
None
ACT  A 404 (-4.6A)
0.89A 5uihA-4w5zA:
undetectable
5uihA-4w5zA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8o LUCIFERASE-LIKE
ENZYMEAMP-COA-LIGASE


(Zophobas
atratus)
PF00501
(AMP-binding)
4 ASP A 101
LEU A 104
TYR A 273
THR A 224
None
0.90A 5uihA-4w8oA:
undetectable
5uihA-4w8oA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x84 RIBOSE-5-PHOSPHATE
ISOMERASE A


(Pseudomonas
aeruginosa)
PF06026
(Rib_5-P_isom_A)
4 ILE A 118
ALA A 207
LEU A 221
ILE A 120
None
0.88A 5uihA-4x84A:
undetectable
5uihA-4x84A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeh KETOL-ACID
REDUCTOISOMERASE


(Ignisphaera
aggregans)
PF01450
(IlvC)
PF07991
(IlvN)
4 ILE A  20
ALA A  74
LEU A 104
ILE A  22
None
0.74A 5uihA-4xehA:
undetectable
5uihA-4xehA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xri PUTATIVE
UNCHARACTERIZED
PROTEIN


(Chaetomium
thermophilum)
PF03810
(IBN_N)
PF13513
(HEAT_EZ)
4 ILE A 720
ALA A 772
LEU A 728
ILE A 716
None
0.77A 5uihA-4xriA:
undetectable
5uihA-4xriA:
6.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3k SEPIAPTERIN
REDUCTASE


(Homo sapiens)
PF00106
(adh_short)
4 ILE A  95
LEU A 241
ILE A 152
THR A 148
None
None
NAP  A 801 (-4.5A)
None
0.64A 5uihA-4z3kA:
undetectable
5uihA-4z3kA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3y BENZOYL-COA
REDUCTASE, PUTATIVE


(Geobacter
metallireducens)
PF01314
(AFOR_C)
PF02730
(AFOR_N)
4 ILE A 150
ALA A 163
LEU A 120
ILE A 149
None
0.90A 5uihA-4z3yA:
undetectable
5uihA-4z3yA:
8.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dxv RETHREADED DHFR

(synthetic
construct)
PF00186
(DHFR_1)
5 ILE A   5
ALA A   7
ILE A 111
TYR A 117
THR A 130
None
NAP  A 201 (-3.7A)
None
None
CME  A 140 ( 4.5A)
0.35A 5uihA-5dxvA:
17.4
5uihA-5dxvA:
73.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dxv RETHREADED DHFR

(synthetic
construct)
PF00186
(DHFR_1)
5 ILE A   5
LEU A  45
ILE A 111
TYR A 117
THR A 130
None
PEG  A 202 (-4.2A)
None
None
CME  A 140 ( 4.5A)
0.61A 5uihA-5dxvA:
17.4
5uihA-5dxvA:
73.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4r KETOL-ACID
REDUCTOISOMERASE


(Ignisphaera
aggregans)
PF01450
(IlvC)
PF07991
(IlvN)
4 ILE A  20
ALA A  74
LEU A 104
ILE A  22
None
0.76A 5uihA-5e4rA:
undetectable
5uihA-5e4rA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE


(Pseudomonas
putida)
PF01494
(FAD_binding_3)
4 ILE A   7
ALA A 152
LEU A 289
ILE A   9
None
0.87A 5uihA-5eowA:
undetectable
5uihA-5eowA:
11.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fda DIHYDROFOLATE
REDUCTASE


(Yersinia pestis)
PF00186
(DHFR_1)
4 ILE A   6
ALA A   8
TYR A 101
THR A 114
None
0.25A 5uihA-5fdaA:
20.7
5uihA-5fdaA:
49.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltg AUTOPHAGY-RELATED
PROTEIN 18


(Ogataea angusta)
no annotation 4 ILE A 206
ALA A 253
LEU A 236
ILE A 218
None
0.80A 5uihA-5ltgA:
undetectable
5uihA-5ltgA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mu4 TAIL TUBULAR PROTEIN
A


(Klebsiella
virus KP32)
PF17212
(Tube)
4 ILE A  50
MET A  20
LEU A 156
ILE A  46
None
0.84A 5uihA-5mu4A:
undetectable
5uihA-5mu4A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0l BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE


(Toxoplasma
gondii)
PF00186
(DHFR_1)
PF00303
(Thymidylat_synt)
4 ALA A  10
ASP A  31
TYR A 157
THR A 172
73X  A 704 (-4.0A)
73X  A 704 (-2.8A)
None
73X  A 704 (-4.2A)
0.21A 5uihA-5t0lA:
19.7
5uihA-5t0lA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tcs KINETOCHORE PROTEIN
NDC80


(Saccharomyces
cerevisiae)
PF03801
(Ndc80_HEC)
4 ILE A 190
MET A 221
LEU A 169
ILE A 187
None
0.57A 5uihA-5tcsA:
undetectable
5uihA-5tcsA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyb PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE


(Pseudomonas
aeruginosa)
no annotation 4 ILE B 113
ALA B  63
ILE B 133
THR B  27
None
0.92A 5uihA-5wybB:
undetectable
5uihA-5wybB:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xb6 UNCHARACTERIZED
PROTEIN YCJY


(Escherichia
coli)
no annotation 4 ILE A 144
ALA A 233
MET A 258
ILE A 147
None
0.89A 5uihA-5xb6A:
undetectable
5uihA-5xb6A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL


(Homo sapiens)
PF00384
(Molybdopterin)
PF09326
(NADH_dhqG_C)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4)
4 ILE M 455
ALA M 492
LEU M 476
ILE M 451
None
0.76A 5uihA-5xtbM:
undetectable
5uihA-5xtbM:
9.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6cxm DIHYDROFOLATE
REDUCTASE


(Mycolicibacterium
smegmatis)
no annotation 7 ILE A   6
ALA A   8
ASP A  28
LEU A  29
ILE A  92
TYR A  98
THR A 111
MMV  A 202 (-4.0A)
NAP  A 201 (-3.9A)
MMV  A 202 (-2.9A)
MMV  A 202 (-4.7A)
MMV  A 202 ( 4.2A)
None
MMV  A 202 (-4.4A)
0.58A 5uihA-6cxmA:
20.1
5uihA-6cxmA:
41.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e4e -

(-)
no annotation 4 ALA A   7
ASP A  27
LEU A  28
THR A 111
MMV  A 202 ( 3.5A)
MMV  A 202 (-2.9A)
MMV  A 202 (-4.2A)
MMV  A 202 (-4.3A)
0.30A 5uihA-6e4eA:
23.9
5uihA-6e4eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g72 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1


(Mus musculus)
no annotation 4 ALA H 236
LEU H 264
ILE H 231
THR H 239
None
0.83A 5uihA-6g72H:
undetectable
5uihA-6g72H:
26.04