SIMILAR PATTERNS OF AMINO ACIDS FOR 5UIH_A_8CVA201
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1cz3 | DIHYDROFOLATEREDUCTASE (Thermotogamaritima) |
PF00186(DHFR_1) | 4 | ALA A 8ASP A 27ILE A 100THR A 121 | None | 0.46A | 5uihA-1cz3A:20.0 | 5uihA-1cz3A:30.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dr6 | DIHYDROFOLATEREDUCTASE (Gallus gallus) |
PF00186(DHFR_1) | 4 | ILE A 7ALA A 9TYR A 121THR A 136 | HBI A 198 (-4.1A)HBI A 198 ( 3.6A)NoneHBI A 198 ( 4.5A) | 0.26A | 5uihA-1dr6A:19.2 | 5uihA-1dr6A:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fnn | CELL DIVISIONCONTROL PROTEIN 6 (Pyrobaculumaerophilum) |
PF09079(Cdc6_C)PF13401(AAA_22) | 4 | ILE A 90ALA A 88LEU A 136ILE A 93 | None | 0.85A | 5uihA-1fnnA:undetectable | 5uihA-1fnnA:11.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oaa | SEPIAPTERINREDUCTASE (Mus musculus) |
PF00106(adh_short) | 4 | ILE A 99LEU A 245ILE A 156THR A 152 | NoneNoneNAP A 800 (-4.1A)None | 0.73A | 5uihA-1oaaA:undetectable | 5uihA-1oaaA:14.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pgv | TROPOMODULIN TMD-1 (Caenorhabditiselegans) |
no annotation | 4 | ILE A 286ALA A 282LEU A 310ILE A 289 | None | 0.74A | 5uihA-1pgvA:undetectable | 5uihA-1pgvA:13.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pzx | HYPOTHETICAL PROTEINAPC36103 (Geobacillusstearothermophilus) |
PF02645(DegV) | 4 | ILE A 5ALA A 24LEU A 114ILE A 85 | None | 0.89A | 5uihA-1pzxA:undetectable | 5uihA-1pzxA:15.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qcj | POKEWEED ANTIVIRALPROTEIN (Phytolaccaamericana) |
PF00161(RIP) | 4 | MET A 173LEU A 54ILE A 144THR A 11 | None | 0.87A | 5uihA-1qcjA:undetectable | 5uihA-1qcjA:15.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t3g | X-LINKEDINTERLEUKIN-1RECEPTOR ACCESSORYPROTEIN-LIKE 1 (Homo sapiens) |
PF01582(TIR) | 4 | ILE A 510LEU A 431ILE A 474THR A 478 | None | 0.84A | 5uihA-1t3gA:2.1 | 5uihA-1t3gA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u70 | DIHYDROFOLATEREDUCTASE (Mus musculus) |
PF00186(DHFR_1) | 4 | ILE A 7ALA A 9TYR A 121THR A 136 | MTX A 187 (-3.8A)NDP A 188 (-3.6A)NoneMTX A 187 (-4.4A) | 0.16A | 5uihA-1u70A:18.8 | 5uihA-1u70A:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u71 | DIHYDROFOLATEREDUCTASE (Homo sapiens) |
PF00186(DHFR_1) | 4 | ILE A 7ALA A 9TYR A 121THR A 136 | MXA A 187 (-4.5A)MXA A 187 (-3.6A)NoneMXA A 187 (-4.3A) | 0.30A | 5uihA-1u71A:19.2 | 5uihA-1u71A:27.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uc4 | DIOL DEHYDRASE BETASUBUNIT (Klebsiellaoxytoca) |
PF02288(Dehydratase_MU) | 4 | ILE B 130ALA B 117LEU B 153ILE B 132 | NoneNoneCNC B2601 (-4.0A)None | 0.83A | 5uihA-1uc4B:undetectable | 5uihA-1uc4B:13.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wb0 | CHITOTRIOSIDASE 1 (Homo sapiens) |
PF00704(Glyco_hydro_18) | 4 | ALA A 183ASP A 136LEU A 93TYR A 212 | None | 0.87A | 5uihA-1wb0A:undetectable | 5uihA-1wb0A:10.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yco | BRANCHED-CHAINPHOSPHOTRANSACYLASE (Enterococcusfaecalis) |
PF01515(PTA_PTB) | 4 | ALA A 194LEU A 116ILE A 151THR A 195 | None | 0.89A | 5uihA-1ycoA:undetectable | 5uihA-1ycoA:14.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yve | ACETOHYDROXY ACIDISOMEROREDUCTASE (Spinaciaoleracea) |
PF01450(IlvC)PF07991(IlvN) | 4 | ILE I 364ALA I 497LEU I 471ILE I 360 | None | 0.85A | 5uihA-1yveI:undetectable | 5uihA-1yveI:9.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1zdr | DIHYDROFOLATEREDUCTASE (Geobacillusstearothermophilus) |
PF00186(DHFR_1) | 6 | ILE A 5ALA A 7ASP A 27LEU A 28ILE A 96THR A 115 | NoneNoneNoneSO4 A3486 ( 4.8A)NoneNone | 0.32A | 5uihA-1zdrA:23.4 | 5uihA-1zdrA:31.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2blb | DIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumvivax) |
PF00186(DHFR_1) | 6 | ILE A 13ALA A 15ASP A 53ILE A 173TYR A 179THR A 194 | CP7 A1240 (-4.1A)CP7 A1240 (-3.7A)CP7 A1240 (-3.1A)CP7 A1240 ( 3.8A)NoneCP7 A1240 (-4.1A) | 0.31A | 5uihA-2blbA:19.0 | 5uihA-2blbA:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cun | PHOSPHOGLYCERATEKINASE (Pyrococcushorikoshii) |
PF00162(PGK) | 4 | ILE A 193ALA A 217LEU A 196ILE A 322 | None | 0.91A | 5uihA-2cunA:undetectable | 5uihA-2cunA:9.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fja | ADENYLYLSULFATEREDUCTASE, SUBUNIT A (Archaeoglobusfulgidus) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 4 | ILE A 25ALA A 207LEU A 434ILE A 27 | None | 0.81A | 5uihA-2fjaA:undetectable | 5uihA-2fjaA:7.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h2q | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Trypanosomacruzi) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 5 | ALA A 28ASP A 48ILE A 154TYR A 160THR A 178 | NAP A 523 (-3.7A)NoneNoneNoneNone | 0.32A | 5uihA-2h2qA:18.2 | 5uihA-2h2qA:13.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oip | CHAIN A, CRYSTALSTRUCTURE OF DHFR (Cryptosporidiumhominis) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 5 | ALA A 11ASP A 32LEU A 33TYR A 119THR A 134 | MTX A 605 ( 3.6A)MTX A 605 ( 3.0A)MTX A 605 ( 4.0A)NoneMTX A 605 ( 4.2A) | 0.51A | 5uihA-2oipA:19.6 | 5uihA-2oipA:8.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p4g | HYPOTHETICAL PROTEIN (Corynebacteriumdiphtheriae) |
PF01872(RibD_C) | 4 | ILE A 38ASP A 61TYR A 199THR A 214 | EDO A 278 (-4.7A)EDO A 278 (-3.2A)EDO A 280 (-4.3A)None | 0.43A | 5uihA-2p4gA:15.2 | 5uihA-2p4gA:13.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p4g | HYPOTHETICAL PROTEIN (Corynebacteriumdiphtheriae) |
PF01872(RibD_C) | 4 | ILE A 190ALA A 72LEU A 111ILE A 192 | None | 0.85A | 5uihA-2p4gA:15.2 | 5uihA-2p4gA:13.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pfv | EXOCYST COMPLEXCOMPONENT EXO70 (Saccharomycescerevisiae) |
PF03081(Exo70) | 4 | ILE A 352ALA A 371ILE A 353THR A 372 | None | 0.83A | 5uihA-2pfvA:undetectable | 5uihA-2pfvA:10.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pv7 | T-PROTEIN [INCLUDES:CHORISMATE MUTASE(EC 5.4.99.5) (CM)AND PREPHENATEDEHYDROGENASE (EC1.3.1.12) (PDH)] (Haemophilusinfluenzae) |
PF02153(PDH) | 4 | ILE A 103ALA A 145LEU A 174ILE A 105 | None | 0.76A | 5uihA-2pv7A:undetectable | 5uihA-2pv7A:15.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qi9 | VITAMIN B12 IMPORTSYSTEM PERMEASEPROTEIN BTUC (Escherichiacoli) |
PF01032(FecCD) | 4 | ILE A 256ALA A 68LEU A 288ILE A 253 | None | 0.85A | 5uihA-2qi9A:undetectable | 5uihA-2qi9A:12.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qk8 | DIHYDROFOLATEREDUCTASE (Bacillusanthracis) |
PF00186(DHFR_1) | 4 | ALA A 8LEU A 29TYR A 102THR A 115 | MTX A 200 ( 3.4A)MTX A 200 ( 4.3A)NoneMTX A 200 ( 4.4A) | 0.48A | 5uihA-2qk8A:23.6 | 5uihA-2qk8A:29.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uzf | NAPHTHOATE SYNTHASE (Staphylococcusaureus) |
PF00378(ECH_1) | 4 | ILE A 105ALA A 222ASP A 240ILE A 106 | None | 0.78A | 5uihA-2uzfA:undetectable | 5uihA-2uzfA:15.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2va1 | URIDYLATE KINASE (Ureaplasmaparvum) |
PF00696(AA_kinase) | 4 | ILE A 6ALA A 146LEU A 209ILE A 8 | None | 0.74A | 5uihA-2va1A:undetectable | 5uihA-2va1A:14.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w3w | DIHYDROFOLATEREDUCTASE (Mycobacteriumavium) |
PF00186(DHFR_1) | 6 | ALA A 11ASP A 31LEU A 32ILE A 102TYR A 108THR A 121 | VG9 A1168 ( 3.8A)VG9 A1168 (-3.0A)VG9 A1168 (-4.7A)VG9 A1168 ( 4.2A)NoneVG9 A1168 ( 4.7A) | 0.39A | 5uihA-2w3wA:23.2 | 5uihA-2w3wA:26.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w9s | DIHYDROFOLATEREDUCTASE TYPE 1FROM TN4003 (Staphylococcusaureus) |
PF00186(DHFR_1) | 6 | ILE A 5ALA A 7ASP A 27LEU A 28TYR A 98THR A 111 | TOP A1160 (-4.2A)TOP A1160 ( 3.6A)TOP A1160 (-2.8A)TOP A1160 ( 4.6A)NoneTOP A1160 ( 4.5A) | 0.35A | 5uihA-2w9sA:24.0 | 5uihA-2w9sA:29.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wae | PENICILLIN-BINDINGPROTEIN 2B (Streptococcuspneumoniae) |
PF00905(Transpeptidase)PF03717(PBP_dimer) | 4 | ILE A 308ASP A 494LEU A 495ILE A 63 | None | 0.90A | 5uihA-2waeA:undetectable | 5uihA-2waeA:8.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xvg | ALPHA XYLOSIDASE (Cellvibriojaponicus) |
PF01055(Glyco_hydro_31)PF16338(DUF4968)PF17137(DUF5110) | 4 | ILE A 612ALA A 605ASP A 553ILE A 95 | None | 0.89A | 5uihA-2xvgA:undetectable | 5uihA-2xvgA:5.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b5q | PUTATIVE SULFATASEYIDJ (Bacteroidesthetaiotaomicron) |
PF00884(Sulfatase)PF16347(DUF4976) | 5 | ALA A 57LEU A 334ILE A 310TYR A 34THR A 328 | NoneNoneNoneNoneEDO A 503 (-4.0A) | 1.14A | 5uihA-3b5qA:undetectable | 5uihA-3b5qA:11.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dfr | DIHYDROFOLATEREDUCTASE (Lactobacilluscasei) |
PF00186(DHFR_1) | 4 | ALA A 6ASP A 26LEU A 27THR A 116 | MTX A 164 (-3.8A)MTX A 164 ( 2.9A)MTX A 164 ( 4.5A)MTX A 164 ( 4.3A) | 0.33A | 5uihA-3dfrA:22.0 | 5uihA-3dfrA:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dg8 | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumfalciparum) |
PF00186(DHFR_1) | 5 | ILE A 14ALA A 16ASP A 54TYR A 170THR A 185 | RJ6 A 609 (-4.5A)RJ6 A 609 (-3.7A)RJ6 A 609 (-3.0A)NDP A 610 ( 4.9A)RJ6 A 609 ( 4.5A) | 0.21A | 5uihA-3dg8A:19.1 | 5uihA-3dg8A:15.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dxi | PUTATIVE ALDOLASE (Bacteroidesvulgatus) |
PF00682(HMGL-like) | 4 | ILE A 154ALA A 120ILE A 115THR A 123 | None | 0.85A | 5uihA-3dxiA:undetectable | 5uihA-3dxiA:14.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i8a | DIHYDROFOLATEREDUCTASE (Staphylococcusaureus) |
PF00186(DHFR_1) | 5 | ALA X 7ASP X 27LEU X 28TYR X 98THR X 111 | N22 X 219 ( 3.6A)N22 X 219 (-2.8A)N22 X 219 (-4.4A)NoneN22 X 219 (-4.4A) | 0.42A | 5uihA-3i8aX:24.0 | 5uihA-3i8aX:29.37 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ia4 | DIHYDROFOLATEREDUCTASE (Moritellaprofunda) |
PF00186(DHFR_1) | 6 | ILE A 6ALA A 8LEU A 29ILE A 96TYR A 102THR A 115 | MTX A 164 (-4.0A)MTX A 164 ( 3.7A)MTX A 164 (-4.0A)MTX A 164 ( 4.2A)NoneMTX A 164 (-4.3A) | 0.55A | 5uihA-3ia4A:25.9 | 5uihA-3ia4A:34.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ian | CHITINASE (Lactococcuslactis) |
PF00704(Glyco_hydro_18) | 4 | ALA A 198ASP A 158LEU A 121TYR A 229 | EDO A 361 ( 4.7A)NoneNoneEDO A 361 (-4.5A) | 0.87A | 5uihA-3ianA:undetectable | 5uihA-3ianA:13.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ihv | SUSD HOMOLOG (Bacteroidesthetaiotaomicron) |
PF07980(SusD_RagB)PF14322(SusD-like_3) | 4 | ILE A 120ALA A 39LEU A 137ILE A 124 | None | 0.82A | 5uihA-3ihvA:undetectable | 5uihA-3ihvA:10.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iuo | ATP-DEPENDENT DNAHELICASE RECQ (Porphyromonasgingivalis) |
no annotation | 4 | ILE A 628ALA A 642LEU A 653ILE A 632 | None | 0.77A | 5uihA-3iuoA:undetectable | 5uihA-3iuoA:18.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ix9 | DIHYDROFOLATEREDUCTASE (Streptococcuspneumoniae) |
PF00186(DHFR_1) | 4 | ILE A 8ALA A 10LEU A 31THR A 119 | MTX A 200 (-4.1A)MTX A 200 (-3.8A)MTX A 200 ( 4.1A)MTX A 200 ( 4.5A) | 0.32A | 5uihA-3ix9A:23.0 | 5uihA-3ix9A:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jck | 26S PROTEASOMEREGULATORY SUBUNITRPN3 (Saccharomycescerevisiae) |
PF01399(PCI)PF08375(Rpn3_C) | 4 | ILE A 293ALA A 270LEU A 310ILE A 294 | None | 0.89A | 5uihA-3jckA:undetectable | 5uihA-3jckA:14.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kjr | DIHYDROFOLATEREDUCTASE/THYMIDYLATE SYNTHASE (Babesia bovis) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 4 | ALA A 16ASP A 37TYR A 129THR A 144 | NAP A 512 (-3.7A)NoneNoneNone | 0.19A | 5uihA-3kjrA:19.4 | 5uihA-3kjrA:9.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l9x | GLUTATHIONE-REGULATED POTASSIUM-EFFLUXSYSTEM PROTEIN KEFC,LINKER, ANCILLARYPROTEIN KEFF (Escherichiacoli) |
PF02254(TrkA_N)PF02525(Flavodoxin_2) | 4 | ILE A1002ALA A1056LEU A1100ILE A1004 | None | 0.85A | 5uihA-3l9xA:2.2 | 5uihA-3l9xA:11.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lmk | METABOTROPICGLUTAMATE RECEPTOR 5 (Homo sapiens) |
PF01094(ANF_receptor) | 4 | ILE A 37ALA A 39LEU A 73ILE A 36 | None | 0.77A | 5uihA-3lmkA:3.3 | 5uihA-3lmkA:10.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lnl | UPF0135 PROTEINSA1388 (Staphylococcusaureus) |
PF01784(NIF3) | 4 | ILE A 283ALA A 302LEU A 325ILE A 285 | None | 0.84A | 5uihA-3lnlA:undetectable | 5uihA-3lnlA:13.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oet | ERYTHRONATE-4-PHOSPHATE DEHYDROGENASE (Salmonellaenterica) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C)PF11890(DUF3410) | 4 | ILE A 119ALA A 168LEU A 203ILE A 121 | None | 0.92A | 5uihA-3oetA:undetectable | 5uihA-3oetA:11.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pvz | UDP-N-ACETYLGLUCOSAMINE 4,6-DEHYDRATASE (Aliivibriofischeri) |
PF02719(Polysacc_synt_2) | 4 | ILE A 270ALA A 201LEU A 5ILE A 265 | NoneSCN A 604 ( 4.9A)NoneNone | 0.71A | 5uihA-3pvzA:undetectable | 5uihA-3pvzA:15.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rg9 | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Trypanosomabrucei) |
PF00186(DHFR_1) | 5 | ALA A 34ASP A 54ILE A 160TYR A 166THR A 184 | WRA A 602 (-3.9A)WRA A 602 (-2.9A)WRA A 602 ( 3.9A)NoneWRA A 602 (-4.2A) | 0.27A | 5uihA-3rg9A:18.3 | 5uihA-3rg9A:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sob | LOW-DENSITYLIPOPROTEINRECEPTOR-RELATEDPROTEIN 6 (Homo sapiens) |
PF00058(Ldl_recept_b)PF14670(FXa_inhibition) | 4 | ALA B 101MET B 152LEU B 187ILE B 119 | None | 0.90A | 5uihA-3sobB:undetectable | 5uihA-3sobB:12.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t3c | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | ILE A 85ALA A 28LEU A 76ILE A 89 | None017 A 201 (-3.5A)NoneNone | 0.75A | 5uihA-3t3cA:undetectable | 5uihA-3t3cA:21.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tq9 | DIHYDROFOLATEREDUCTASE (Coxiellaburnetii) |
PF00186(DHFR_1) | 6 | ILE A 6ALA A 8ASP A 28LEU A 29ILE A 96THR A 115 | MTX A2001 (-4.0A)MTX A2001 ( 3.4A)MTX A2001 (-2.7A)MTX A2001 (-3.9A)MTX A2001 ( 4.2A)MTX A2001 (-4.3A) | 0.40A | 5uihA-3tq9A:23.8 | 5uihA-3tq9A:32.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u02 | PUTATIVETRANSCRIPTION-ASSOCIATED PROTEIN TFIIS (Pyrococcusfuriosus) |
PF08489(DUF1743) | 4 | ILE A 3ALA A 33LEU A 75ILE A 69 | None | 0.84A | 5uihA-3u02A:undetectable | 5uihA-3u02A:15.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u3g | RIBONUCLEASE H (unculturedorganism) |
no annotation | 4 | ILE D 25LEU D 57ILE D 4THR D 8 | None | 0.76A | 5uihA-3u3gD:undetectable | 5uihA-3u3gD:19.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3um6 | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumfalciparum) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 5 | ILE A 14ASP A 54ILE A 164TYR A 170THR A 185 | 1CY A 609 (-4.3A)1CY A 609 (-2.9A)1CY A 609 ( 4.0A)None1CY A 609 (-4.3A) | 0.25A | 5uihA-3um6A:19.1 | 5uihA-3um6A:7.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vco | DIHYDROFOLATEREDUCTASE (Schistosomamansoni) |
PF00186(DHFR_1) | 5 | ALA A 8ASP A 28ILE A 111TYR A 117THR A 133 | None | 0.47A | 5uihA-3vcoA:18.8 | 5uihA-3vcoA:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zcw | KINESIN-LIKE PROTEINKIF11 (Homo sapiens) |
PF00225(Kinesin) | 4 | ILE A 19LEU A 320ILE A 332THR A 328 | NoneNone4A2 A1366 (-3.9A)None | 0.66A | 5uihA-3zcwA:undetectable | 5uihA-3zcwA:12.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a5o | BIFUNCTIONAL PROTEINFOLD (Pseudomonasaeruginosa) |
PF00763(THF_DHG_CYH)PF02882(THF_DHG_CYH_C) | 4 | ILE A 226ALA A 253LEU A 5ILE A 228 | None | 0.88A | 5uihA-4a5oA:undetectable | 5uihA-4a5oA:15.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4axn | CHITINASE C1 (Serratiamarcescens) |
PF00704(Glyco_hydro_18) | 4 | ALA A 177ASP A 137LEU A 100TYR A 208 | ACT A1331 ( 3.9A)NoneNoneACT A1331 (-4.6A) | 0.81A | 5uihA-4axnA:undetectable | 5uihA-4axnA:12.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bzi | SEC23P (Saccharomycescerevisiae) |
PF00626(Gelsolin)PF04810(zf-Sec23_Sec24)PF04811(Sec23_trunk)PF04815(Sec23_helical)PF08033(Sec23_BS) | 4 | ILE A 490LEU A 65ILE A 502THR A 506 | None | 0.80A | 5uihA-4bziA:undetectable | 5uihA-4bziA:8.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f3y | DIHYDRODIPICOLINATEREDUCTASE (Burkholderiathailandensis) |
PF01113(DapB_N)PF05173(DapB_C) | 4 | ILE A 6ALA A 70LEU A 96ILE A 8 | None | 0.81A | 5uihA-4f3yA:2.0 | 5uihA-4f3yA:16.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fdj | N-ACETYLGALACTOSAMINE-6-SULFATASE (Homo sapiens) |
PF00884(Sulfatase)PF14707(Sulfatase_C) | 4 | ILE A 265MET A 41LEU A 37ILE A 261 | None | 0.90A | 5uihA-4fdjA:undetectable | 5uihA-4fdjA:10.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4flc | ADENYLOSUCCINATELYASE (Homo sapiens) |
PF00206(Lyase_1)PF10397(ADSL_C) | 4 | ILE A 237ALA A 235ASP A 223ILE A 238 | None | 0.85A | 5uihA-4flcA:undetectable | 5uihA-4flcA:11.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g8z | DIHYDROFOLATEREDUCTASE (Pneumocystisjirovecii) |
PF00186(DHFR_1) | 5 | ILE X 10ALA X 12ILE X 123TYR X 129THR X 144 | TOP X 301 (-4.2A)NDP X 302 ( 3.8A)TOP X 301 ( 4.0A)NoneTOP X 301 (-4.5A) | 0.23A | 5uihA-4g8zX:18.7 | 5uihA-4g8zX:19.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h96 | DIHYDROFOLATEREDUCTASE (Candidaalbicans) |
PF00186(DHFR_1) | 5 | ILE A 9ALA A 11ILE A 112TYR A 118THR A 133 | 14Q A 202 (-4.3A)14Q A 202 ( 3.7A)14Q A 202 ( 4.2A)None14Q A 202 ( 4.6A) | 0.30A | 5uihA-4h96A:16.5 | 5uihA-4h96A:26.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h98 | DIHYDROFOLATEREDUCTASE ([Candida]glabrata) |
PF00186(DHFR_1) | 5 | ILE A 9ALA A 11ILE A 121TYR A 127THR A 140 | 14Q A 302 (-4.1A)14Q A 302 ( 3.4A)14Q A 302 ( 4.0A)None14Q A 302 (-4.2A) | 0.20A | 5uihA-4h98A:17.0 | 5uihA-4h98A:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ha6 | PYRIDOXINE 4-OXIDASE (Mesorhizobiumloti) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 4 | ILE A 20ALA A 260LEU A 489ILE A 22 | None | 0.81A | 5uihA-4ha6A:undetectable | 5uihA-4ha6A:12.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i7h | PEROXIDE STRESSSENSING REGULATOR (Streptococcuspyogenes) |
PF01475(FUR) | 4 | ILE A 39ASP A 11LEU A 10ILE A 35 | None | 0.91A | 5uihA-4i7hA:undetectable | 5uihA-4i7hA:18.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4m2x | DIHYDROFOLATEREDUCTASE (Mycobacteriumtuberculosis) |
PF00186(DHFR_1) | 6 | ILE A 5ALA A 7ASP A 27ILE A 94TYR A 100THR A 113 | TMQ A 202 (-4.0A)TMQ A 202 ( 3.5A)TMQ A 202 ( 2.7A)TMQ A 202 ( 3.8A)NoneTMQ A 202 (-4.2A) | 0.25A | 5uihA-4m2xA:21.6 | 5uihA-4m2xA:30.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m7v | DIHYDROFOLATEREDUCTASE (Enterococcusfaecalis) |
PF00186(DHFR_1) | 5 | ILE A 5ALA A 7ASP A 27LEU A 28THR A 116 | RAR A 200 (-4.0A)RAR A 200 ( 3.6A)RAR A 200 (-2.6A)RAR A 200 (-3.8A)RAR A 200 (-4.4A) | 0.46A | 5uihA-4m7vA:23.3 | 5uihA-4m7vA:26.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o6g | UNCHARACTERIZEDPROTEIN (Mycobacteriumtuberculosis) |
PF15598(Imm61) | 4 | ILE A 56ALA A 71MET A 74ILE A 47 | None | 0.85A | 5uihA-4o6gA:undetectable | 5uihA-4o6gA:24.16 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4p68 | DIHYDROFOLATEREDUCTASE (Escherichiacoli) |
PF00186(DHFR_1) | 6 | ILE A 5ALA A 7ASP A 27ILE A 94TYR A 100THR A 113 | MTX A 201 (-4.1A)MTX A 201 ( 4.0A)MTX A 201 (-3.0A)MTX A 201 ( 4.3A)NoneMTX A 201 ( 4.5A) | 0.19A | 5uihA-4p68A:27.9 | 5uihA-4p68A:98.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q66 | PROTEIN BCH1 (Saccharomycescerevisiae) |
no annotation | 4 | ALA K 403LEU K 484ILE K 490THR K 391 | None | 0.85A | 5uihA-4q66K:undetectable | 5uihA-4q66K:7.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4toq | CLASS III CHITINASE (Punica granatum) |
PF00704(Glyco_hydro_18) | 4 | ALA A 156ASP A 123LEU A 75TYR A 183 | None | 0.84A | 5uihA-4toqA:undetectable | 5uihA-4toqA:13.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uri | CHITINASE-RELATEDAGGLUTININ (Robiniapseudoacacia) |
PF00704(Glyco_hydro_18) | 4 | ALA A 155ASP A 112LEU A 67TYR A 185 | MPD A 401 (-3.4A)NoneNoneMPD A 401 (-4.8A) | 0.84A | 5uihA-4uriA:undetectable | 5uihA-4uriA:16.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4usq | PYRIDINENUCLEOTIDE-DISULFIDEOXIDOREDUCTASE (Cellvibrio sp.BR) |
PF13738(Pyr_redox_3) | 4 | ILE A 16ALA A 130LEU A 324ILE A 18 | None | 0.90A | 5uihA-4usqA:undetectable | 5uihA-4usqA:13.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w5u | CHITINASE (Streptomycesthermoviolaceus) |
no annotation | 4 | ALA B 219ASP B 179LEU B 136TYR B 250 | None | 0.89A | 5uihA-4w5uB:undetectable | 5uihA-4w5uB:11.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w5z | CHITINASE 60 (Moritellamarina) |
PF00704(Glyco_hydro_18) | 4 | ALA A 189ASP A 149LEU A 112TYR A 220 | ACT A 404 ( 3.1A)NoneNoneACT A 404 (-4.6A) | 0.89A | 5uihA-4w5zA:undetectable | 5uihA-4w5zA:12.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w8o | LUCIFERASE-LIKEENZYMEAMP-COA-LIGASE (Zophobasatratus) |
PF00501(AMP-binding) | 4 | ASP A 101LEU A 104TYR A 273THR A 224 | None | 0.90A | 5uihA-4w8oA:undetectable | 5uihA-4w8oA:9.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x84 | RIBOSE-5-PHOSPHATEISOMERASE A (Pseudomonasaeruginosa) |
PF06026(Rib_5-P_isom_A) | 4 | ILE A 118ALA A 207LEU A 221ILE A 120 | None | 0.88A | 5uihA-4x84A:undetectable | 5uihA-4x84A:16.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xeh | KETOL-ACIDREDUCTOISOMERASE (Ignisphaeraaggregans) |
PF01450(IlvC)PF07991(IlvN) | 4 | ILE A 20ALA A 74LEU A 104ILE A 22 | None | 0.74A | 5uihA-4xehA:undetectable | 5uihA-4xehA:16.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xri | PUTATIVEUNCHARACTERIZEDPROTEIN (Chaetomiumthermophilum) |
PF03810(IBN_N)PF13513(HEAT_EZ) | 4 | ILE A 720ALA A 772LEU A 728ILE A 716 | None | 0.77A | 5uihA-4xriA:undetectable | 5uihA-4xriA:6.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z3k | SEPIAPTERINREDUCTASE (Homo sapiens) |
PF00106(adh_short) | 4 | ILE A 95LEU A 241ILE A 152THR A 148 | NoneNoneNAP A 801 (-4.5A)None | 0.64A | 5uihA-4z3kA:undetectable | 5uihA-4z3kA:15.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z3y | BENZOYL-COAREDUCTASE, PUTATIVE (Geobactermetallireducens) |
PF01314(AFOR_C)PF02730(AFOR_N) | 4 | ILE A 150ALA A 163LEU A 120ILE A 149 | None | 0.90A | 5uihA-4z3yA:undetectable | 5uihA-4z3yA:8.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5dxv | RETHREADED DHFR (syntheticconstruct) |
PF00186(DHFR_1) | 5 | ILE A 5ALA A 7ILE A 111TYR A 117THR A 130 | NoneNAP A 201 (-3.7A)NoneNoneCME A 140 ( 4.5A) | 0.35A | 5uihA-5dxvA:17.4 | 5uihA-5dxvA:73.74 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5dxv | RETHREADED DHFR (syntheticconstruct) |
PF00186(DHFR_1) | 5 | ILE A 5LEU A 45ILE A 111TYR A 117THR A 130 | NonePEG A 202 (-4.2A)NoneNoneCME A 140 ( 4.5A) | 0.61A | 5uihA-5dxvA:17.4 | 5uihA-5dxvA:73.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e4r | KETOL-ACIDREDUCTOISOMERASE (Ignisphaeraaggregans) |
PF01450(IlvC)PF07991(IlvN) | 4 | ILE A 20ALA A 74LEU A 104ILE A 22 | None | 0.76A | 5uihA-5e4rA:undetectable | 5uihA-5e4rA:12.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eow | 6-HYDROXYNICOTINATE3-MONOOXYGENASE (Pseudomonasputida) |
PF01494(FAD_binding_3) | 4 | ILE A 7ALA A 152LEU A 289ILE A 9 | None | 0.87A | 5uihA-5eowA:undetectable | 5uihA-5eowA:11.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5fda | DIHYDROFOLATEREDUCTASE (Yersinia pestis) |
PF00186(DHFR_1) | 4 | ILE A 6ALA A 8TYR A 101THR A 114 | None | 0.25A | 5uihA-5fdaA:20.7 | 5uihA-5fdaA:49.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ltg | AUTOPHAGY-RELATEDPROTEIN 18 (Ogataea angusta) |
no annotation | 4 | ILE A 206ALA A 253LEU A 236ILE A 218 | None | 0.80A | 5uihA-5ltgA:undetectable | 5uihA-5ltgA:9.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mu4 | TAIL TUBULAR PROTEINA (Klebsiellavirus KP32) |
PF17212(Tube) | 4 | ILE A 50MET A 20LEU A 156ILE A 46 | None | 0.84A | 5uihA-5mu4A:undetectable | 5uihA-5mu4A:24.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t0l | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Toxoplasmagondii) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 4 | ALA A 10ASP A 31TYR A 157THR A 172 | 73X A 704 (-4.0A)73X A 704 (-2.8A)None73X A 704 (-4.2A) | 0.21A | 5uihA-5t0lA:19.7 | 5uihA-5t0lA:10.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tcs | KINETOCHORE PROTEINNDC80 (Saccharomycescerevisiae) |
PF03801(Ndc80_HEC) | 4 | ILE A 190MET A 221LEU A 169ILE A 187 | None | 0.57A | 5uihA-5tcsA:undetectable | 5uihA-5tcsA:13.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wyb | PROBABLE ENOYL-COAHYDRATASE/ISOMERASE (Pseudomonasaeruginosa) |
no annotation | 4 | ILE B 113ALA B 63ILE B 133THR B 27 | None | 0.92A | 5uihA-5wybB:undetectable | 5uihA-5wybB:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xb6 | UNCHARACTERIZEDPROTEIN YCJY (Escherichiacoli) |
no annotation | 4 | ILE A 144ALA A 233MET A 258ILE A 147 | None | 0.89A | 5uihA-5xb6A:undetectable | 5uihA-5xb6A:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xtb | NADH-UBIQUINONEOXIDOREDUCTASE 75KDA SUBUNIT,MITOCHONDRIAL (Homo sapiens) |
PF00384(Molybdopterin)PF09326(NADH_dhqG_C)PF10588(NADH-G_4Fe-4S_3)PF13510(Fer2_4) | 4 | ILE M 455ALA M 492LEU M 476ILE M 451 | None | 0.76A | 5uihA-5xtbM:undetectable | 5uihA-5xtbM:9.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6cxm | DIHYDROFOLATEREDUCTASE (Mycolicibacteriumsmegmatis) |
no annotation | 7 | ILE A 6ALA A 8ASP A 28LEU A 29ILE A 92TYR A 98THR A 111 | MMV A 202 (-4.0A)NAP A 201 (-3.9A)MMV A 202 (-2.9A)MMV A 202 (-4.7A)MMV A 202 ( 4.2A)NoneMMV A 202 (-4.4A) | 0.58A | 5uihA-6cxmA:20.1 | 5uihA-6cxmA:41.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6e4e | - (-) |
no annotation | 4 | ALA A 7ASP A 27LEU A 28THR A 111 | MMV A 202 ( 3.5A)MMV A 202 (-2.9A)MMV A 202 (-4.2A)MMV A 202 (-4.3A) | 0.30A | 5uihA-6e4eA:23.9 | 5uihA-6e4eA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g72 | NADH-UBIQUINONEOXIDOREDUCTASE CHAIN1 (Mus musculus) |
no annotation | 4 | ALA H 236LEU H 264ILE H 231THR H 239 | None | 0.83A | 5uihA-6g72H:undetectable | 5uihA-6g72H:26.04 |