SIMILAR PATTERNS OF AMINO ACIDS FOR 5UIG_A_EDTA501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0c XYLOSE ISOMERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF01261
(AP_endonuc_2) 		4 ASN A 115
THR A 114
ARG A 102
ILE A 175
 None
 1.19A 5uigA-1a0cA:
undetectable		 5uigA-1a0cA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0e XYLOSE ISOMERASE

(Thermotoga
neapolitana) 		PF01261
(AP_endonuc_2) 		4 ASN A 115
THR A 114
ARG A 102
ILE A 175
 None
 1.22A 5uigA-1a0eA:
undetectable		 5uigA-1a0eA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1alq CP254 BETA-LACTAMASE

(Staphylococcus
aureus) 		PF13354
(Beta-lactamase2) 		4 ASN A 136
THR A 133
ILE A 167
GLU A 168
 None
 1.34A 5uigA-1alqA:
undetectable		 5uigA-1alqA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cs1 PROTEIN
(CYSTATHIONINE
GAMMA-SYNTHASE)

(Escherichia
coli) 		PF01053
(Cys_Met_Meta_PP) 		4 ASN A 258
THR A 364
ILE A 373
GLU A 370
 None
 1.30A 5uigA-1cs1A:
0.0		 5uigA-1cs1A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj0 PSEUDOURIDINE
SYNTHASE I

(Escherichia
coli) 		PF01416
(PseudoU_synth_1) 		4 THR A  84
ASN A  88
ILE A  16
GLU A  17
 None
 1.08A 5uigA-1dj0A:
undetectable		 5uigA-1dj0A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dll TETANUS TOXIN

(Clostridium
tetani) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		4 ASN A1045
THR A1037
ILE A1058
GLU A1057
 None
 1.33A 5uigA-1dllA:
undetectable		 5uigA-1dllA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc9 PHOTOSYSTEM II D1
PROTEASE

(Tetradesmus
obliquus) 		PF03572
(Peptidase_S41)
PF13180
(PDZ_2) 		4 ASN A 314
ASN A 367
ARG A 281
GLU A 441
 None
 1.34A 5uigA-1fc9A:
1.3		 5uigA-1fc9A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q80 SARCOPLASMIC
CALCIUM-BINDING
PROTEIN

(Hediste
diversicolor) 		PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		4 THR A 165
ASN A 166
ILE A 137
GLU A 149
 None
 1.15A 5uigA-1q80A:
undetectable		 5uigA-1q80A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s94 S-SYNTAXIN

(Doryteuthis
pealeii) 		PF00804
(Syntaxin) 		4 THR A 121
ARG A 117
ILE A 103
GLU A 100
 None
 1.17A 5uigA-1s94A:
3.2		 5uigA-1s94A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ven BETA-AMYLASE

(Bacillus cereus) 		PF00686
(CBM_20)
PF01373
(Glyco_hydro_14) 		4 ASN A 218
THR A 223
ILE A 231
GLU A 228
 None
 1.10A 5uigA-1venA:
undetectable		 5uigA-1venA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT

(Methanocaldococcus
jannaschii) 		PF01420
(Methylase_S) 		4 ASN A 112
THR A 111
ILE A  59
GLU A  57
 None
 1.30A 5uigA-1yf2A:
undetectable		 5uigA-1yf2A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7e PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF01370
(Epimerase)
PF02911
(Formyl_trans_C) 		4 THR A 538
ASN A 567
ILE A 623
GLU A 633
 None
 1.01A 5uigA-1z7eA:
undetectable		 5uigA-1z7eA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT

(Chlamydia
trachomatis) 		PF00268
(Ribonuc_red_sm) 		4 ASN A  22
THR A 172
ILE A 241
GLU A 244
 None
 1.15A 5uigA-2aniA:
2.7		 5uigA-2aniA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5d ALPHA-AMYLASE

(Thermotoga
maritima) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 ASN X 372
ARG X 366
ILE X  48
GLU X  49
 None
 1.26A 5uigA-2b5dX:
3.6		 5uigA-2b5dX:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bll PROTEIN YFBG

(Escherichia
coli) 		PF01370
(Epimerase) 		4 THR A 538
ASN A 567
ILE A 623
GLU A 633
 None
 1.18A 5uigA-2bllA:
undetectable		 5uigA-2bllA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)

(Geobacillus
stearothermophilus) 		PF00121
(TIM) 		4 THR A 138
ARG A 133
ILE A 168
GLU A 166
 None
None
None
PGA  A 301 (-2.9A)
 1.07A 5uigA-2btmA:
undetectable		 5uigA-2btmA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cx6 HYPOTHETICAL PROTEIN
YHCO

(Escherichia
coli) 		PF01337
(Barstar) 		4 THR A  62
ARG A  65
ILE A  11
GLU A  10
 None
 1.29A 5uigA-2cx6A:
undetectable		 5uigA-2cx6A:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		4 ASN A  48
ARG A  31
ILE A  66
GLU A  62
 None
 1.27A 5uigA-2e4uA:
undetectable		 5uigA-2e4uA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fb0 CONSERVED
HYPOTHETICAL PROTEIN

(Bacteroides
thetaiotaomicron) 		PF03992
(ABM) 		4 ASN A  11
THR A  13
ASN A  14
GLU A  83
 None
 1.22A 5uigA-2fb0A:
2.1		 5uigA-2fb0A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus) 		PF00343
(Phosphorylase) 		4 ASN A 696
THR A 691
ILE A 458
GLU A 698
 None
 1.35A 5uigA-2gj4A:
undetectable		 5uigA-2gj4A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2go7 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Streptococcus
pneumoniae) 		PF13419
(HAD_2) 		4 ASN A 112
THR A 115
ASN A  80
GLU A  78
 None
 1.16A 5uigA-2go7A:
undetectable		 5uigA-2go7A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inv INSULIN
FRUCTOTRANSFERASE

(Bacillus sp.
snu-7) 		no annotation 4 ASN A 334
THR A 308
ASN A 310
ILE A 297
 None
 1.27A 5uigA-2invA:
undetectable		 5uigA-2invA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nba PREPILIN-TYPE
CLEAVAGE/METHYLATION
N-TERMINAL DOMAIN
PROTEIN

(Neisseria
subflava) 		PF16732
(ComP_DUS) 		4 THR A  70
ARG A  86
ILE A  64
GLU A  66
 None
 1.13A 5uigA-2nbaA:
undetectable		 5uigA-2nbaA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3v MEVALONATE KINASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 ASN A 186
THR A 209
ASN A 205
ILE A 221
 None
 1.32A 5uigA-2r3vA:
undetectable		 5uigA-2r3vA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbi PYRUVATE
DECARBOXYLASE

(Acetobacter
pasteurianus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ASN A 390
THR A 537
ASN A 363
ILE A 461
 None
 1.19A 5uigA-2vbiA:
undetectable		 5uigA-2vbiA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yek BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo sapiens) 		PF00439
(Bromodomain) 		4 THR A  76
ASN A  77
ARG A  74
GLU A 183
 None
 1.21A 5uigA-2yekA:
3.3		 5uigA-2yekA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv5 YJEQ PROTEIN

(Aquifex
aeolicus) 		PF03193
(RsgA_GTPase) 		4 THR A  59
ARG A  31
ILE A  62
GLU A  63
 None
 1.19A 5uigA-2yv5A:
undetectable		 5uigA-2yv5A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yw4 4-HYDROXY-2-OXOGLUTA
RATE
ALDOLASE/2-DEYDRO-3-
DEOXYPHOSPHOGLUCONAT
E ALDOLASE

(Thermus
thermophilus) 		PF01081
(Aldolase) 		4 THR A  48
ARG A  22
ILE A  44
GLU A  43
 None
 1.28A 5uigA-2yw4A:
undetectable		 5uigA-2yw4A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zcx TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		4 THR A 108
ARG A 112
ILE A 149
GLU A 152
 None
 1.07A 5uigA-2zcxA:
undetectable		 5uigA-2zcxA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2

(Thermotoga
maritima;
synthetic
construct) 		PF00749
(tRNA-synt_1c)
PF02686
(Glu-tRNAGln) 		4 THR C 562
ARG C 553
ILE C 569
GLU C 570
 U  E  35 ( 4.6A)
C  E  34 ( 2.8A)
None
None
 1.28A 5uigA-3al0C:
undetectable		 5uigA-3al0C:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bv6 METAL-DEPENDENT
HYDROLASE

(Vibrio cholerae) 		PF13483
(Lactamase_B_3) 		4 ASN A  57
THR A  56
ASN A  55
GLU A  29
 None
 1.32A 5uigA-3bv6A:
undetectable		 5uigA-3bv6A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1

(Saccharomyces
cerevisiae) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		4 THR A 835
ASN A 839
ILE A 609
GLU A 848
 None
 1.22A 5uigA-3cmmA:
undetectable		 5uigA-3cmmA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN

(Homo sapiens) 		PF08324
(PUL) 		4 THR A 704
ASN A 708
ARG A 744
GLU A 539
 None
 1.06A 5uigA-3ebbA:
undetectable		 5uigA-3ebbA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gry DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00398
(RrnaAD) 		4 ASN A 260
ARG A 267
ILE A 242
GLU A 241
 None
 1.00A 5uigA-3gryA:
undetectable		 5uigA-3gryA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5t AMINOTRANSFERASE

(Rhodobacter
sphaeroides) 		PF00202
(Aminotran_3) 		4 THR A 218
ARG A 145
ILE A 211
GLU A 212
 None
 1.11A 5uigA-3i5tA:
undetectable		 5uigA-3i5tA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3maz SIGNAL-TRANSDUCING
ADAPTOR PROTEIN 1

(Homo sapiens) 		PF00017
(SH2) 		4 THR A 260
ASN A 263
ILE A 219
GLU A 218
 None
 1.26A 5uigA-3mazA:
undetectable		 5uigA-3mazA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcx SUSD SUPERFAMILY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 THR A 135
ASN A 139
ILE A 125
GLU A 126
 None
 1.27A 5uigA-3mcxA:
2.7		 5uigA-3mcxA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0w ABC BRANCHED CHAIN
AMINO ACID FAMILY
TRANSPORTER,
PERIPLASMIC LIGAND
BINDING PROTEIN

(Paraburkholderia
xenovorans) 		PF13458
(Peripla_BP_6) 		4 ASN A 302
THR A 300
ASN A 301
ILE A 255
 None
 1.09A 5uigA-3n0wA:
undetectable		 5uigA-3n0wA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0y LIPOPROTEIN

(Colwellia
psychrerythraea) 		PF05960
(DUF885) 		4 ASN A 590
ASN A 601
ARG A 461
ILE A 100
 None
 1.26A 5uigA-3o0yA:
undetectable		 5uigA-3o0yA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oy2 GLYCOSYLTRANSFERASE
B736L

(Paramecium
bursaria
Chlorella virus
NY2A) 		no annotation 4 ASN A 191
ASN A 279
ARG A 196
GLU A 292
 None
 1.31A 5uigA-3oy2A:
undetectable		 5uigA-3oy2A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p52 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Campylobacter
jejuni) 		PF02540
(NAD_synthase) 		4 THR A   7
ARG A  45
ILE A  14
GLU A  16
 None
 1.26A 5uigA-3p52A:
undetectable		 5uigA-3p52A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 THR A  64
ASN A  65
ARG A 128
GLU A 389
 None
 0.85A 5uigA-3pblA:
28.3		 5uigA-3pblA:
29.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poy NEUREXIN-1-ALPHA

(Bos taurus) 		PF00008
(EGF)
PF02210
(Laminin_G_2) 		4 ASN A 804
THR A 789
ARG A 791
GLU A 819
 None
 1.33A 5uigA-3poyA:
undetectable		 5uigA-3poyA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pst PROTEIN DOA1

(Saccharomyces
cerevisiae) 		PF08324
(PUL)
PF09070
(PFU) 		4 ASN A 565
THR A 567
ILE A 532
GLU A 531
 None
 1.10A 5uigA-3pstA:
undetectable		 5uigA-3pstA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qak ADENOSINE RECEPTOR
A2A,LYSOZYME CHIMERA

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 ASN A  39
THR A  41
ASN A  42
ARG A 102
GLU A 294
 None
 0.67A 5uigA-3qakA:
31.3		 5uigA-3qakA:
71.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qak ADENOSINE RECEPTOR
A2A,LYSOZYME CHIMERA

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 ASN A  39
THR A  41
ASN A  42
ILE A 292
GLU A 294
 None
 0.51A 5uigA-3qakA:
31.3		 5uigA-3qakA:
71.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2q UNCHARACTERIZED
GST-LIKE PROTEIN
YIBF

(Escherichia
coli) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 THR A 150
ASN A 152
ILE A  93
GLU A  94
 None
 1.34A 5uigA-3r2qA:
undetectable		 5uigA-3r2qA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgz HYDROXYACID OXIDASE
2

(Rattus
norvegicus) 		PF01070
(FMN_dh) 		4 THR A  61
ARG A 296
ILE A 342
GLU A 341
 None
 0.85A 5uigA-3sgzA:
undetectable		 5uigA-3sgzA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t24 PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 ASN A 375
THR A 374
ILE A 333
GLU A 341
 None
 1.31A 5uigA-3t24A:
undetectable		 5uigA-3t24A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 THR A  90
ARG A 120
ILE A 337
GLU A 339
 None
SO4  A 408 (-2.6A)
None
GOL  A 404 (-3.7A)
 1.29A 5uigA-3tz6A:
undetectable		 5uigA-3tz6A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3viu PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 2

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 THR A 204
ARG A 307
ILE A 209
GLU A 297
 None
 1.31A 5uigA-3viuA:
undetectable		 5uigA-3viuA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrc CYTOCHROME C'

(Thermochromatium
tepidum) 		PF01322
(Cytochrom_C_2) 		4 ASN A  65
ARG A  72
ILE A   9
GLU A   6
 None
None
HEC  A 200 ( 4.7A)
None
 1.17A 5uigA-3vrcA:
5.3		 5uigA-3vrcA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wb1 UNCHARACTERIZED
PROTEIN MJ0488

(Methanocaldococcus
jannaschii) 		PF11576
(DUF3236) 		4 THR A  45
ASN A  47
ILE A 139
GLU A 140
 SO4  A 202 (-3.4A)
None
None
None
 1.27A 5uigA-3wb1A:
undetectable		 5uigA-3wb1A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3win HA3

(Clostridium
botulinum) 		PF03505
(Clenterotox) 		4 THR E 552
ASN E 600
ARG E 597
ILE E 624
 None
 1.06A 5uigA-3winE:
undetectable		 5uigA-3winE:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zef PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		4 THR B 950
ARG B 953
ILE B 940
GLU B 941
 None
 1.20A 5uigA-3zefB:
undetectable		 5uigA-3zefB:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgb PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Flaveria
pringlei) 		PF00311
(PEPcase) 		4 THR A 228
ARG A 226
ILE A 952
GLU A 948
 None
 1.20A 5uigA-3zgbA:
4.7		 5uigA-3zgbA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3m RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD

(Bacillus
subtilis) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		4 THR A 239
ARG A 216
ILE A 225
GLU A 227
 None
 1.00A 5uigA-4g3mA:
undetectable		 5uigA-4g3mA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h62 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Saccharomyces
cerevisiae) 		PF10156
(Med17) 		4 ASN Q 642
ASN Q 639
ARG Q 550
GLU Q 636
 None
 1.24A 5uigA-4h62Q:
undetectable		 5uigA-4h62Q:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1t RNA-DIRECTED RNA
POLYMERASE L

(Cali
mammarenavirus) 		PF17296
(ArenaCapSnatch) 		4 THR A  64
ASN A  63
ARG A  65
GLU A  74
 None
 1.20A 5uigA-4i1tA:
3.3		 5uigA-4i1tA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kwm HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 ASN A 166
THR A 167
ASN A 168
ILE A 114
 None
 0.97A 5uigA-4kwmA:
undetectable		 5uigA-4kwmA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lej VICILIN

(Pinus
koraiensis) 		PF00190
(Cupin_1) 		4 ASN A 403
ASN A 318
ARG A 286
GLU A 406
 None
PO4  A 502 ( 4.8A)
None
None
 0.96A 5uigA-4lejA:
undetectable		 5uigA-4lejA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg9 F-BOX-LIKE/WD
REPEAT-CONTAINING
PROTEIN TBL1XR1

(Homo sapiens) 		PF00400
(WD40) 		4 THR A 423
ARG A 425
ILE A 394
GLU A 393
 None
 1.15A 5uigA-4lg9A:
undetectable		 5uigA-4lg9A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mgu STRUCTURAL PROTEIN
VP2

(Orthopteran
ambidensovirus
1) 		PF02336
(Denso_VP4) 		4 ASN A 368
THR A  47
ASN A 366
ILE A 135
 None
 1.11A 5uigA-4mguA:
undetectable		 5uigA-4mguA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Methanocaldococcus
jannaschii) 		PF02350
(Epimerase_2) 		4 ASN A  97
THR A  71
ILE A 131
GLU A 129
 UD1  A 400 (-3.4A)
None
None
UD1  A 400 (-3.6A)
 1.34A 5uigA-4nesA:
undetectable		 5uigA-4nesA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		4 THR A 342
ARG A 345
ILE A 275
GLU A 277
 None
 1.16A 5uigA-4oflA:
undetectable		 5uigA-4oflA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plj CAPSID PROTEIN

(Orthohepevirus
A) 		PF03014
(SP2) 		4 ASN A 587
THR A 583
ILE A 595
GLU A 549
 None
 1.16A 5uigA-4pljA:
undetectable		 5uigA-4pljA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qn3 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ASN A  89
THR A  79
ILE A  32
GLU A  30
 None
 0.91A 5uigA-4qn3A:
undetectable		 5uigA-4qn3A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3l MAJOR PILIN PROTEIN

(Streptococcus
pneumoniae) 		no annotation 4 ASN A  65
THR A  67
ASN A 213
GLU A 208
 None
 1.28A 5uigA-4s3lA:
undetectable		 5uigA-4s3lA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trq NUCLEAR MRNA EXPORT
PROTEIN THP1

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		4 THR B 379
ASN B 392
ILE B 388
GLU B 387
 None
 1.18A 5uigA-4trqB:
3.4		 5uigA-4trqB:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trq NUCLEAR MRNA EXPORT
PROTEIN SAC3
NUCLEAR MRNA EXPORT
PROTEIN THP1

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF03399
(SAC3_GANP)
PF01399
(PCI) 		4 THR B 379
ASN B 392
ARG A 428
GLU B 387
 None
 1.18A 5uigA-4trqB:
3.4		 5uigA-4trqB:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0q DNA POLYMERASE THETA

(Homo sapiens) 		PF00476
(DNA_pol_A) 		4 THR A2471
ARG A2448
ILE A2453
GLU A2465
 None
 0.96A 5uigA-4x0qA:
undetectable		 5uigA-4x0qA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnq INFLUENZA H5 HA HEAD
DOMAIN VIETNAM RDT
MUTATIONS

(Influenza A
virus) 		no annotation 4 ASN D 170
THR D 171
ASN D 172
ILE D 121
 None
 1.04A 5uigA-4xnqD:
undetectable		 5uigA-4xnqD:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Brucella ovis) 		PF00497
(SBP_bac_3) 		4 ASN A  81
ASN A  19
ARG A  66
ILE A 159
 GSH  A 401 (-3.3A)
GSH  A 401 (-3.2A)
GSH  A 401 (-3.1A)
GSH  A 401 (-3.6A)
 0.96A 5uigA-4z9nA:
undetectable		 5uigA-4z9nA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zej METALLO-BETA-LACTAMA
SE

(Pseudomonas
stutzeri) 		no annotation 4 THR A 117
ASN A 103
ILE A  86
GLU A 112
 None
 1.28A 5uigA-4zejA:
undetectable		 5uigA-4zejA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3k PUTATIVE
PTERIDINE-DEPENDENT
DIOXYGENASE

(Streptomyces
hygroscopicus) 		no annotation 4 ASN A   9
THR A  12
ARG A  28
GLU A  89
 None
 1.30A 5uigA-5a3kA:
undetectable		 5uigA-5a3kA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
GAMMA

(Methanothermobacter
marburgensis) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 ASN B 207
THR B 208
ILE B 429
GLU B 427
 None
 1.29A 5uigA-5a8rB:
undetectable		 5uigA-5a8rB:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN

(Escherichia
coli;
Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		4 THR A 736
ASN A 737
ILE A 841
GLU A   3
 None
 1.22A 5uigA-5azaA:
2.4		 5uigA-5azaA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d5p HCGB

(Methanococcus
maripaludis) 		PF11576
(DUF3236) 		4 THR A 124
ARG A 152
ILE A  27
GLU A  26
 None
 0.96A 5uigA-5d5pA:
undetectable		 5uigA-5d5pA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e32 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 THR A 200
ASN A 250
ILE A 194
GLU A 190
 None
 1.21A 5uigA-5e32A:
undetectable		 5uigA-5e32A:
20.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5g53 ADENOSINE RECEPTOR
A2A

(Homo sapiens) 		PF00001
(7tm_1) 		4 ASN A  39
THR A  41
ASN A  42
ILE A 292
 None
 0.71A 5uigA-5g53A:
30.2		 5uigA-5g53A:
69.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1k GEM-ASSOCIATED
PROTEIN 5

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 THR A 250
ARG A 252
ILE A 198
GLU A 197
 None
None
None
U  C   3 ( 4.9A)
 1.22A 5uigA-5h1kA:
undetectable		 5uigA-5h1kA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h53 MYOSIN LIGHT CHAIN
1/3, SKELETAL MUSCLE
ISOFORM

(Oryctolagus
cuniculus) 		PF13405
(EF-hand_6) 		4 ASN C 142
ASN C 177
ARG C 151
GLU C 140
 None
 1.27A 5uigA-5h53C:
undetectable		 5uigA-5h53C:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h53 MYOSIN LIGHT CHAIN
1/3, SKELETAL MUSCLE
ISOFORM

(Oryctolagus
cuniculus) 		PF13405
(EF-hand_6) 		4 ASN C 142
THR C 144
ASN C 177
GLU C 183
 None
 1.01A 5uigA-5h53C:
undetectable		 5uigA-5h53C:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5icl LIPOATE--PROTEIN
LIGASE

(Enterococcus
faecalis) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		4 ASN A  81
THR A 149
ASN A  83
ILE A  42
 LAQ  A 401 (-3.8A)
LAQ  A 401 (-3.1A)
LAQ  A 401 ( 4.2A)
LAQ  A 401 ( 4.1A)
 0.96A 5uigA-5iclA:
undetectable		 5uigA-5iclA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqc VP1

(Black queen
cell virus) 		PF08762
(CRPV_capsid) 		4 THR A 104
ASN A 107
ILE A  74
GLU A  75
 None
 1.01A 5uigA-5mqcA:
undetectable		 5uigA-5mqcA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnz DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1

(Homo sapiens) 		no annotation 4 THR B 410
ARG B 412
ILE B 390
GLU B 389
 None
 1.23A 5uigA-5nnzB:
undetectable		 5uigA-5nnzB:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1

(Synechocystis
sp. PCC 6803) 		no annotation 4 ASN 1 424
ASN 1 421
ILE 1 343
GLU 1 342
 None
 1.06A 5uigA-5oy01:
2.6		 5uigA-5oy01:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tu4 PAGF
PRENYLTRANSFERASE

(Planktothrix
agardhii) 		no annotation 4 THR A 253
ASN A 251
ILE A 287
GLU A 278
 None
 1.22A 5uigA-5tu4A:
undetectable		 5uigA-5tu4A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC24A
VESICLE-TRAFFICKING
PROTEIN SEC22B

(Homo sapiens;
Mus musculus) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS)
PF13774
(Longin) 		4 THR B 540
ASN B 539
ILE C 113
GLU B 815
 None
 1.23A 5uigA-5vniB:
undetectable		 5uigA-5vniB:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Desulfovibrio
gigas) 		no annotation 4 THR A 350
ASN A 356
ILE A 338
GLU A 335
 None
 1.15A 5uigA-5xmjA:
3.2		 5uigA-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zbh NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME,NEUROPEPTID
E Y RECEPTOR TYPE 1

(Homo sapiens;
Escherichia
virus T4) 		no annotation 4 ASN A  73
THR A  75
ASN A  76
ARG A 138
 None
 0.92A 5uigA-5zbhA:
25.5		 5uigA-5zbhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zbq NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		no annotation 4 ASN A  73
THR A  75
ASN A  76
ARG A 138
 None
 1.09A 5uigA-5zbqA:
23.5		 5uigA-5zbqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a0z HEMAGGLUTININ,ENVELO
PE GLYCOPROTEIN

(Influenza A
virus;
Human
immunodeficiency
virus 1) 		no annotation 4 ASN A 170
THR A 171
ASN A 172
ILE A 121
 None
 1.02A 5uigA-6a0zA:
undetectable		 5uigA-6a0zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aqf ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A

(Escherichia
coli;
Homo sapiens) 		no annotation 6 ASN A  39
THR A  41
ASN A  42
ARG A 102
ILE A 292
GLU A 294
 None
 0.56A 5uigA-6aqfA:
41.1		 5uigA-6aqfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6at7 PHENYLALANINE
AMMONIA-LYASE

(Sorghum bicolor) 		no annotation 4 ASN A 525
THR A 521
ILE A 554
GLU A 550
 None
 1.33A 5uigA-6at7A:
2.5		 5uigA-6at7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b6l GLYCOSYL HYDROLASE
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
cellulosilyticus) 		no annotation 4 ASN A  73
THR A  72
ILE A 752
GLU A 753
 None
 1.03A 5uigA-6b6lA:
undetectable		 5uigA-6b6lA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bsu XYLOGLUCAN
6-XYLOSYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 4 THR A 417
ASN A 408
ILE A 360
GLU A 357
 None
 1.08A 5uigA-6bsuA:
undetectable		 5uigA-6bsuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f1s CGLIIR PROTEIN

(Corynebacterium
glutamicum) 		no annotation 4 ASN A 598
THR A 608
ILE A 594
GLU A 595
 None
None
None
FMT  A 701 ( 3.9A)
 1.32A 5uigA-6f1sA:
undetectable		 5uigA-6f1sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8y THREONYLCARBAMOYL-AM
P SYNTHASE

(Pyrococcus
abyssi) 		no annotation 4 THR A  33
ARG A 121
ILE A 132
GLU A 133
 THR  A 401 ( 3.8A)
THR  A 401 (-3.1A)
None
None
 1.34A 5uigA-6f8yA:
undetectable		 5uigA-6f8yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gqz -

(-) 		no annotation 4 ASN A  72
THR A  77
ARG A  79
ILE A  52
 None
 1.28A 5uigA-6gqzA:
undetectable		 5uigA-6gqzA:
undetectable