SIMILAR PATTERNS OF AMINO ACIDS FOR 5UHG_C_RFPC1201_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE

(Pseudomonas
putida) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 ARG A 177
GLN A 138
PHE A 448
LEU A 141
 None
 1.43A 5uhgC-1re5A:
0.8		 5uhgC-1re5A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3

(Homo sapiens) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		4 ARG A  56
GLN A 167
PHE A 161
LEU A 170
 None
 1.48A 5uhgC-1y8pA:
0.0		 5uhgC-1y8pA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3z BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF00232
(Glyco_hydro_1) 		4 ARG A 248
GLN A 307
PHE A 252
LEU A 305
 None
 1.48A 5uhgC-2e3zA:
0.0		 5uhgC-2e3zA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		4 ARG A 148
GLN A 173
PHE A 170
LEU A 143
 None
 1.28A 5uhgC-2phkA:
0.0		 5uhgC-2phkA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3frq REPRESSOR PROTEIN
MPHR(A)

(Escherichia
coli) 		PF00440
(TetR_N) 		4 ARG A  51
GLN A 111
PHE A  28
LEU A 110
 None
 1.36A 5uhgC-3frqA:
0.7		 5uhgC-3frqA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il2 REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX

(Thermus
thermophilus) 		PF02629
(CoA_binding)
PF06971
(Put_DNA-bind_N) 		4 ARG A  46
GLN A  33
PHE A  43
LEU A  37
 None
 1.46A 5uhgC-3il2A:
0.0		 5uhgC-3il2A:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwf -

(-) 		no annotation 4 ARG A 596
GLN A 539
PHE A 597
LEU A 523
 None
 1.43A 5uhgC-6bwfA:
0.0		 5uhgC-6bwfA:
undetectable