SIMILAR PATTERNS OF AMINO ACIDS FOR 5UHG_C_RFPC1201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pss PHOTOSYNTHETIC
REACTION CENTER

(Rhodobacter
sphaeroides) 		PF00124
(Photo_RC) 		5 LEU L 193
HIS L 230
ASN M  44
ILE L 224
ARG L 231
 U10  L 272 (-3.8A)
FE  M 302 (-3.4A)
None
U10  L 272 (-4.4A)
None
 1.17A 5uhgC-1pssL:
undetectable		 5uhgC-1pssL:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3b GLUCOSE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF01547
(SBP_bac_1) 		5 LEU A 298
ASP A 278
ASN A  35
ILE A   5
HIS A 119
 None
GLC  A2605 (-2.7A)
None
None
GLC  A2605 ( 4.7A)
 1.20A 5uhgC-2b3bA:
0.0		 5uhgC-2b3bA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi0 HYPOTHETICAL PROTEIN
RV0216

(Mycobacterium
tuberculosis) 		no annotation 5 ASP A 149
ARG A 174
ILE A 175
ARG A 136
HIS A 100
 None
 1.13A 5uhgC-2bi0A:
0.6		 5uhgC-2bi0A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e67 HYPOTHETICAL PROTEIN
TTHB029

(Thermus
thermophilus) 		PF04794
(YdjC) 		5 ASP A  21
HIS A 215
ARG A 232
PRO A 227
HIS A  60
 MG  A 301 (-2.6A)
None
None
None
MG  A 301 (-3.3A)
 1.41A 5uhgC-2e67A:
0.0		 5uhgC-2e67A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9y ISWI ONE COMPLEX
PROTEIN 3

(Saccharomyces
cerevisiae) 		PF15612
(WHIM1) 		5 LEU B 185
ASP B 213
ARG B 388
ASN B 255
ILE B 380
 None
 1.40A 5uhgC-2y9yB:
undetectable		 5uhgC-2y9yB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynp COATOMER SUBUNIT
BETA'

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF04053
(Coatomer_WDAD) 		5 LEU A 132
ASP A  92
SER A 114
ILE A 100
ARG A  80
 None
 1.26A 5uhgC-2ynpA:
0.0		 5uhgC-2ynpA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zds PUTATIVE DNA-BINDING
PROTEIN

(Streptomyces
coelicolor) 		PF01261
(AP_endonuc_2)
PF07582
(AP_endonuc_2_N) 		5 ASP A 125
SER A  70
ASN A 207
ILE A 128
ARG A 174
 None
 1.32A 5uhgC-2zdsA:
undetectable		 5uhgC-2zdsA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anv D-SERINE DEHYDRATASE

(Gallus gallus) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		5 LEU A 104
HIS A 108
ARG A  41
PRO A  42
ILE A  64
 None
 1.34A 5uhgC-3anvA:
0.0		 5uhgC-3anvA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		6 GLN B 412
ASP B 415
HIS B 425
ARG B 428
PRO B 459
ASN B 463
 None
 0.80A 5uhgC-3hkzB:
21.8		 5uhgC-3hkzB:
29.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpp SUCRASE-ISOMALTASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		5 LEU A 187
ASP A 191
ARG A 136
ASN A 265
ILE A 287
 None
 1.33A 5uhgC-3lppA:
1.3		 5uhgC-3lppA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qum FAB 5D3D11 HEAVY
CHAIN
PROSTATE-SPECIFIC
ANTIGEN

(Homo sapiens;
Mus musculus) 		PF00089
(Trypsin)
PF07654
(C1-set)
PF07686
(V-set) 		5 ASP P 122
SER H  76
ARG H  94
PRO H  52
ILE H  29
 GAL  P 301 ( 3.9A)
GAL  P 301 ( 4.9A)
None
None
None
 1.42A 5uhgC-3qumP:
undetectable		 5uhgC-3qumP:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qz4 ENDO-1,4-BETA-XYLANA
SE D

(Bacteroides
thetaiotaomicron) 		PF04616
(Glyco_hydro_43) 		5 LEU A 303
ARG A 297
PRO A 331
ASN A 269
ILE A 274
 None
 1.26A 5uhgC-3qz4A:
1.1		 5uhgC-3qz4A:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N) 		5 LEU A 187
ASP A 191
ARG A 103
ASN A 268
ILE A 289
 None
GOL  A1010 (-2.9A)
GOL  A1010 ( 4.5A)
None
None
 1.35A 5uhgC-3welA:
1.4		 5uhgC-3welA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgy DNA TOPOISOMERASE
3-ALPHA

(Homo sapiens) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		5 LEU A 560
ASP A 522
ARG A 255
PRO A 514
ILE A 259
 None
 1.43A 5uhgC-4cgyA:
3.2		 5uhgC-4cgyA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 322
ASP A 386
HIS A 384
ILE A 392
ARG A 388
 None
 1.32A 5uhgC-4lggA:
undetectable		 5uhgC-4lggA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		6 GLN B 425
ASP B 428
HIS B 438
ARG B 441
PRO B 472
ASN B 476
 None
 1.05A 5uhgC-4qiwB:
25.7		 5uhgC-4qiwB:
28.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7z CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus) 		PF00493
(MCM) 		5 ASP A 321
ARG A 879
PRO A 346
ILE A 875
HIS A 323
 None
 1.40A 5uhgC-4r7zA:
undetectable		 5uhgC-4r7zA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zcf RESTRICTION
ENDONUCLEASE
ECOP15I, RESTRICTION
SUBUNIT

(Escherichia
coli) 		PF04851
(ResIII) 		5 LEU C 101
ASP C 139
SER C 104
ILE C 782
HIS C 135
 None
 1.36A 5uhgC-4zcfC:
undetectable		 5uhgC-4zcfC:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT EPSILON

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		5 LEU e 540
GLN e 111
ARG e 431
PRO e 530
ASN e 432
 None
 1.31A 5uhgC-5gw5e:
undetectable		 5uhgC-5gw5e:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw7 GLUCOSIDASE YGJK

(Escherichia
coli) 		PF01204
(Trehalase) 		5 ASP A  22
HIS A  26
SER A 316
ASN A  65
ILE A  64
 None
 1.49A 5uhgC-5gw7A:
undetectable		 5uhgC-5gw7A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B

(Mus musculus) 		PF00149
(Metallophos) 		5 LEU A 118
ASP A  28
SER A  74
ILE A 322
HIS A 236
 None
ZN  A 502 (-3.0A)
None
None
ZN  A 501 (-3.3A)
 1.36A 5uhgC-5karA:
undetectable		 5uhgC-5karA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nws SAACMM

(Streptomyces
antibioticus) 		no annotation 5 LEU A 262
ARG A 195
PRO A 189
ILE A 188
ARG A 229
 None
 1.44A 5uhgC-5nwsA:
undetectable		 5uhgC-5nwsA:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oon UNDECAPRENYL-DIPHOSP
HATASE

(Escherichia
coli) 		no annotation 5 LEU A 246
SER A 193
ILE A 179
ARG A 261
HIS A  30
 None
None
None
None
OLC  A 304 (-4.5A)
 1.45A 5uhgC-5oonA:
undetectable		 5uhgC-5oonA:
5.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		10 GLN C 429
ASP C 432
HIS C 442
ARG C 445
SER C 447
ARG C 456
PRO C 480
ASN C 484
ILE C 488
HIS C 671
 None
 1.09A 5uhgC-5tw1C:
50.5		 5uhgC-5tw1C:
91.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		10 LEU C 427
GLN C 429
ASP C 432
HIS C 442
ARG C 445
SER C 447
PRO C 480
ASN C 484
ILE C 488
HIS C 671
 None
 0.81A 5uhgC-5tw1C:
50.5		 5uhgC-5tw1C:
91.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		9 LEU C 427
GLN C 429
HIS C 442
ARG C 445
SER C 447
PRO C 480
ASN C 484
ILE C 488
ARG C 604
 None
 1.38A 5uhgC-5tw1C:
50.5		 5uhgC-5tw1C:
91.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vys GDP-MANNOSE
4,6-DEHYDRATASE /
GDP-4-AMINO-4,6-DIDE
OXY-D-MANNOSE
FORMYLTRANSFERASE

(Brucella
melitensis) 		PF00551
(Formyl_trans_N) 		5 LEU A 164
ARG A  45
PRO A  17
ILE A 169
HIS A 136
 None
GDP  A 303 (-2.6A)
None
None
1YJ  A 301 (-4.5A)
 1.39A 5uhgC-5vysA:
undetectable		 5uhgC-5vysA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k ACTF

(Rhodothermus
marinus) 		no annotation 5 LEU F 179
GLN F 195
HIS F  88
ARG F 196
ARG F  91
 None
 1.30A 5uhgC-6f0kF:
0.0		 5uhgC-6f0kF:
5.86