SIMILAR PATTERNS OF AMINO ACIDS FOR 5UHD_C_RFPC1201_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cf2 PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)

(Methanothermus
fervidus) 		no annotation 4 ARG P 270
PHE P 276
ASP P 303
LEU P 248
 None
 1.37A 5uhdC-1cf2P:
0.0		 5uhdC-1cf2P:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3v CELLULASE

(Phanerochaete
chrysosporium) 		PF00840
(Glyco_hydro_7) 		4 ARG A 297
PHE A 220
ASP A 209
LEU A 133
 None
 1.44A 5uhdC-1z3vA:
0.4		 5uhdC-1z3vA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtl HEMOGLOBIN LINKER
CHAIN L1

(Lumbricus
terrestris) 		PF00057
(Ldl_recept_a)
PF16915
(Eryth_link_C) 		4 ARG M 176
PHE M 196
ASP M 205
LEU M  50
 None
 0.90A 5uhdC-2gtlM:
2.2		 5uhdC-2gtlM:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtt NUCLEOPROTEIN

(Rabies
lyssavirus) 		PF00945
(Rhabdo_ncap) 		4 ARG A  98
PHE A 213
ASP A 211
LEU A 143
 None
 1.42A 5uhdC-2gttA:
0.0		 5uhdC-2gttA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2leh SURVIVAL OF MOTOR
NEURON
PROTEIN-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF04938
(SIP1) 		4 ARG A 240
PHE A 202
ASP A 206
LEU A 149
 None
 1.37A 5uhdC-2lehA:
undetectable		 5uhdC-2lehA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS

(Mycobacterium
tuberculosis) 		PF12282
(H_kinase_N) 		4 ARG A 147
PHE A  37
ASP A  34
LEU A  41
 None
 1.09A 5uhdC-2ykfA:
0.0		 5uhdC-2ykfA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e5b ISOCITRATE LYASE

(Brucella
abortus) 		PF00463
(ICL) 		4 ARG A 207
PHE A  16
ASP A  17
LEU A 306
 None
 1.44A 5uhdC-3e5bA:
0.0		 5uhdC-3e5bA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s3f TYROSINE-PROTEIN
PHOSPHATASE 10D

(Drosophila
melanogaster) 		PF00102
(Y_phosphatase) 		4 ARG A  86
PHE A  64
ASP A  66
LEU A 122
 None
 1.44A 5uhdC-3s3fA:
0.0		 5uhdC-3s3fA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tk8 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E

(Burkholderia
pseudomallei) 		PF00132
(Hexapep)
PF14602
(Hexapep_2)
PF14805
(THDPS_N_2) 		4 ARG A  82
PHE A 155
ASP A  77
LEU A 207
 None
None
None
EDO  A 313 ( 4.5A)
 1.46A 5uhdC-3tk8A:
0.0		 5uhdC-3tk8A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		4 ARG A 194
PHE A 175
ASP A 177
LEU A 125
 None
 1.22A 5uhdC-4eyoA:
0.0		 5uhdC-4eyoA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 ARG A 624
PHE A 515
ASP A 514
LEU A 556
 None
 1.34A 5uhdC-4hwtA:
0.4		 5uhdC-4hwtA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8u LINKER L1

(Glossoscolex
paulistus) 		PF16915
(Eryth_link_C) 		4 ARG M 176
PHE M 196
ASP M 205
LEU M  50
 None
 1.05A 5uhdC-4u8uM:
undetectable		 5uhdC-4u8uM:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ar1 CELL DIVISION
CONTROL PROTEIN 11

(Saccharomyces
cerevisiae) 		PF00735
(Septin) 		4 ARG A 221
PHE A 204
ASP A 213
LEU A 272
 None
 1.47A 5uhdC-5ar1A:
undetectable		 5uhdC-5ar1A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ar1 CELL DIVISION
CONTROL PROTEIN 11

(Saccharomyces
cerevisiae) 		PF00735
(Septin) 		4 ARG A 221
PHE A 204
ASP A 213
LEU A 276
 None
 1.44A 5uhdC-5ar1A:
undetectable		 5uhdC-5ar1A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0a GLUCANASE

(Trichoderma
harzianum) 		no annotation 4 ARG A 271
PHE A 209
ASP A 198
LEU A 137
 ARG  A 271 ( 0.6A)
PHE  A 209 ( 1.3A)
ASP  A 198 (-0.6A)
LEU  A 137 ( 0.6A)
 1.45A 5uhdC-5w0aA:
0.3		 5uhdC-5w0aA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE

(Rhodothermus
marinus) 		no annotation 4 ARG B 110
PHE B 263
ASP B 260
LEU B 386
 None
 1.34A 5uhdC-6f0kB:
0.0		 5uhdC-6f0kB:
6.04