SIMILAR PATTERNS OF AMINO ACIDS FOR 5UHC_C_RFPC1201_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aoa T-FIMBRIN

(Homo sapiens) 		PF00307
(CH) 		3 PHE A 369
ASP A 357
LEU A 231
 PHE  A 369 ( 1.3A)
ASP  A 357 ( 0.6A)
LEU  A 231 ( 0.6A)
 0.68A 5uhcC-1aoaA:
0.0		 5uhcC-1aoaA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cc1 HYDROGENASE (LARGE
SUBUNIT)

(Desulfomicrobium
baculatum) 		PF00374
(NiFeSe_Hases) 		3 PHE L 239
ASP L 237
LEU L 468
 None
 0.74A 5uhcC-1cc1L:
0.0		 5uhcC-1cc1L:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d7w MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		3 PHE C 203
ASP C 205
LEU C 197
 None
 0.71A 5uhcC-1d7wC:
0.0		 5uhcC-1d7wC:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dmg RIBOSOMAL PROTEIN L4

(Thermotoga
maritima) 		PF00573
(Ribosomal_L4) 		3 PHE A 203
ASP A  38
LEU A 108
 None
 0.66A 5uhcC-1dmgA:
0.0		 5uhcC-1dmgA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezf FARNESYL-DIPHOSPHATE
FARNESYLTRANSFERASE

(Homo sapiens) 		PF00494
(SQS_PSY) 		3 PHE A 210
ASP A 272
LEU A 178
 None
 0.76A 5uhcC-1ezfA:
0.9		 5uhcC-1ezfA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl9 REVERSE GYRASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		3 PHE B 473
ASP B 256
LEU B 458
 None
 0.75A 5uhcC-1gl9B:
2.4		 5uhcC-1gl9B:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlg LIPASE, GASTRIC

(Homo sapiens) 		PF00561
(Abhydrolase_1) 		3 PHE A 241
ASP A 247
LEU A 222
 None
 0.60A 5uhcC-1hlgA:
0.0		 5uhcC-1hlgA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iov D-ALA:D-ALA LIGASE

(Escherichia
coli) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		3 PHE A 188
ASP A 257
LEU A 193
 None
MG  A 330 (-2.8A)
None
 0.79A 5uhcC-1iovA:
0.0		 5uhcC-1iovA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jgc BACTERIOFERRITIN

(Rhodobacter
capsulatus) 		PF00210
(Ferritin) 		3 PHE A 133
ASP A  90
LEU A 123
 None
 0.75A 5uhcC-1jgcA:
0.0		 5uhcC-1jgcA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji6 PESTICIDIAL CRYSTAL
PROTEIN CRY3BB

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 PHE A 286
ASP A 288
LEU A  88
 None
 0.59A 5uhcC-1ji6A:
undetectable		 5uhcC-1ji6A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jjv DEPHOSPHO-COA KINASE

(Haemophilus
influenzae) 		PF01121
(CoaE) 		3 PHE A 110
ASP A  31
LEU A  25
 None
 0.71A 5uhcC-1jjvA:
undetectable		 5uhcC-1jjvA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jne IMAGINAL DISC GROWTH
FACTOR-2

(Drosophila
melanogaster) 		PF00704
(Glyco_hydro_18) 		3 PHE A 394
ASP A   9
LEU A 316
 None
 0.67A 5uhcC-1jneA:
undetectable		 5uhcC-1jneA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jod OLFACTORY MARKER
PROTEIN

(Mus musculus) 		PF06554
(Olfactory_mark) 		3 PHE A 241
ASP A 118
LEU A 145
 None
ZN  A 304 (-3.0A)
ZN  A 302 ( 4.8A)
 0.61A 5uhcC-1jodA:
undetectable		 5uhcC-1jodA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kn5 TRANSCRIPTION
REGULATORY PROTEIN
ADR6

(Saccharomyces
cerevisiae) 		PF01388
(ARID) 		3 PHE A  48
ASP A  52
LEU A  38
 None
 0.77A 5uhcC-1kn5A:
undetectable		 5uhcC-1kn5A:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o51 HYPOTHETICAL PROTEIN
TM0021

(Thermotoga
maritima) 		PF02641
(DUF190) 		3 PHE A  20
ASP A  12
LEU A  79
 None
 0.70A 5uhcC-1o51A:
undetectable		 5uhcC-1o51A:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyw ATP-DEPENDENT DNA
HELICASE

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		3 PHE A 158
ASP A 157
LEU A 368
 None
 0.61A 5uhcC-1oywA:
undetectable		 5uhcC-1oywA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9j TRANSKETOLASE

(Leishmania
mexicana) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 PHE A  60
ASP A  58
LEU A 419
 None
 0.77A 5uhcC-1r9jA:
undetectable		 5uhcC-1r9jA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5k AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE

(Salmonella
enterica) 		PF00583
(Acetyltransf_1) 		3 PHE A  46
ASP A  59
LEU A  84
 None
 0.72A 5uhcC-1s5kA:
undetectable		 5uhcC-1s5kA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfj 3-DEHYDROQUINATE
DEHYDRATASE

(Staphylococcus
aureus) 		PF01487
(DHquinase_I) 		3 PHE A 181
ASP A 183
LEU A 172
 None
 0.60A 5uhcC-1sfjA:
undetectable		 5uhcC-1sfjA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t34 ATRIAL NATRIURETIC
PEPTIDE RECEPTOR A

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		3 PHE A 388
ASP A 382
LEU A 254
 None
 0.78A 5uhcC-1t34A:
undetectable		 5uhcC-1t34A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1te7 HYPOTHETICAL UPF0267
PROTEIN YQFB

(Escherichia
coli) 		PF04266
(ASCH) 		3 PHE A  44
ASP A  46
LEU A  17
 None
 0.63A 5uhcC-1te7A:
undetectable		 5uhcC-1te7A:
6.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tk1 COPROPORPHYRINOGEN
III OXIDASE

(Saccharomyces
cerevisiae) 		PF01218
(Coprogen_oxidas) 		3 PHE A 235
ASP A 233
LEU A 185
 None
 0.62A 5uhcC-1tk1A:
undetectable		 5uhcC-1tk1A:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkl COPROPORPHYRINOGEN
III OXIDASE

(Saccharomyces
cerevisiae) 		PF01218
(Coprogen_oxidas) 		3 PHE A 235
ASP A 233
LEU A 185
 None
 0.58A 5uhcC-1tklA:
undetectable		 5uhcC-1tklA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tly NUCLEOSIDE-SPECIFIC
CHANNEL-FORMING
PROTEIN TSX

(Escherichia
coli) 		PF03502
(Channel_Tsx) 		3 PHE A  48
ASP A  46
LEU A  94
 None
 0.76A 5uhcC-1tlyA:
undetectable		 5uhcC-1tlyA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ujn DEHYDROQUINATE
SYNTHASE

(Thermus
thermophilus) 		PF01761
(DHQ_synthase) 		3 PHE A 102
ASP A  98
LEU A 114
 None
 0.78A 5uhcC-1ujnA:
undetectable		 5uhcC-1ujnA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uls PUTATIVE
3-OXOACYL-ACYL
CARRIER PROTEIN
REDUCTASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		3 PHE A  92
ASP A  90
LEU A  98
 None
 0.79A 5uhcC-1ulsA:
undetectable		 5uhcC-1ulsA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxo YDEN PROTEIN

(Bacillus
subtilis) 		PF06821
(Ser_hydrolase) 		3 PHE A 142
ASP A 136
LEU A 106
 None
 0.56A 5uhcC-1uxoA:
undetectable		 5uhcC-1uxoA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT

(Thermotoga
maritima) 		PF01039
(Carboxyl_trans) 		3 PHE A 345
ASP A 181
LEU A 515
 None
 0.78A 5uhcC-1vrgA:
undetectable		 5uhcC-1vrgA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w3i 2-KETO-3-DEOXY
GLUCONATE ALDOLASE

(Sulfolobus
solfataricus) 		PF00701
(DHDPS) 		3 PHE A 265
ASP A 268
LEU A 248
 None
 0.79A 5uhcC-1w3iA:
undetectable		 5uhcC-1w3iA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wf0 TAR DNA-BINDING
PROTEIN-43

(Homo sapiens) 		PF00076
(RRM_1) 		3 PHE A  36
ASP A  34
LEU A  58
 None
 0.68A 5uhcC-1wf0A:
undetectable		 5uhcC-1wf0A:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1n 4-ALPHA-GLUCANOTRANS
FERASE

(Solanum
tuberosum) 		PF02446
(Glyco_hydro_77) 		3 PHE A 318
ASP A 316
LEU A  32
 None
 0.70A 5uhcC-1x1nA:
undetectable		 5uhcC-1x1nA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xl3 PROTEIN TYPE A
SECRETION CONTROL
PROTEIN

(Yersinia pestis) 		PF07201
(HrpJ)
PF09059
(TyeA) 		3 PHE A 223
ASP A 227
LEU C   5
 None
 0.65A 5uhcC-1xl3A:
undetectable		 5uhcC-1xl3A:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7x MAJOR VAULT PROTEIN

(Homo sapiens) 		PF01505
(Vault) 		3 PHE A 101
ASP A  76
LEU A  89
 None
 0.77A 5uhcC-1y7xA:
undetectable		 5uhcC-1y7xA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzf LIPASE/ACYLHYDROLASE

(Enterococcus
faecalis) 		PF13472
(Lipase_GDSL_2) 		3 PHE A   7
ASP A   9
LEU A  27
 None
 0.73A 5uhcC-1yzfA:
undetectable		 5uhcC-1yzfA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzf LIPASE/ACYLHYDROLASE

(Enterococcus
faecalis) 		PF13472
(Lipase_GDSL_2) 		3 PHE A   7
ASP A   9
LEU A 181
 None
 0.77A 5uhcC-1yzfA:
undetectable		 5uhcC-1yzfA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7c CHORIONIC
SOMATOMAMMOTROPIN
HORMONE

(Homo sapiens) 		PF00103
(Hormone_1) 		3 PHE A 176
ASP A 171
LEU A  15
 None
 0.77A 5uhcC-1z7cA:
undetectable		 5uhcC-1z7cA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrt CYTOCHROME B

(Rhodobacter
capsulatus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		3 PHE C 369
ASP C 373
LEU C 349
 None
 0.71A 5uhcC-1zrtC:
undetectable		 5uhcC-1zrtC:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8x DIHYDROLIPOYL
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 PHE A  62
ASP A  65
LEU A  53
 None
 0.65A 5uhcC-2a8xA:
undetectable		 5uhcC-2a8xA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2br4 CEPHALOSPORIN
HYDROXYLASE CMCI

(Streptomyces
clavuligerus) 		PF04989
(CmcI) 		3 PHE A 183
ASP A 181
LEU A 216
 None
 0.75A 5uhcC-2br4A:
undetectable		 5uhcC-2br4A:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2col BIFUNCTIONAL
HEMOLYSIN-ADENYLATE
CYCLASE

(Bordetella
pertussis) 		PF03497
(Anthrax_toxA) 		3 PHE A 192
ASP A 190
LEU A 277
 None
MG  A 907 ( 2.8A)
None
 0.73A 5uhcC-2colA:
undetectable		 5uhcC-2colA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dae KIAA0733 PROTEIN

(Homo sapiens) 		PF02845
(CUE) 		3 PHE A  63
ASP A  65
LEU A  47
 None
 0.66A 5uhcC-2daeA:
undetectable		 5uhcC-2daeA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		3 PHE A 351
ASP A 353
LEU A  96
 None
 0.76A 5uhcC-2e4uA:
0.9		 5uhcC-2e4uA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ea3 CHYMOTRYPSIN

(Cellulomonas
bogoriensis) 		PF00089
(Trypsin) 		3 PHE A 166
ASP A  56
LEU A 178
 None
 0.76A 5uhcC-2ea3A:
undetectable		 5uhcC-2ea3A:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epk N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
gordonii) 		PF00728
(Glyco_hydro_20) 		3 PHE X 543
ASP X 541
LEU X 501
 None
 0.79A 5uhcC-2epkX:
undetectable		 5uhcC-2epkX:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1z UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF00443
(UCH)
PF00917
(MATH) 		3 PHE A 324
ASP A 349
LEU A 396
 None
 0.57A 5uhcC-2f1zA:
undetectable		 5uhcC-2f1zA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9b CALBINDIN

(Rattus
norvegicus) 		PF13405
(EF-hand_6)
PF13499
(EF-hand_7) 		3 PHE A 117
ASP A 155
LEU A 127
 None
 0.74A 5uhcC-2g9bA:
undetectable		 5uhcC-2g9bA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ger PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1

(Homo sapiens) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		3 PHE A 182
ASP A 186
LEU A 253
 None
 0.75A 5uhcC-2gerA:
undetectable		 5uhcC-2gerA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gr9 PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1

(Homo sapiens) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		3 PHE A 182
ASP A 186
LEU A 253
 None
 0.71A 5uhcC-2gr9A:
undetectable		 5uhcC-2gr9A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ho4 HALOACID
DEHALOGENASE-LIKE
HYDROLASE DOMAIN
CONTAINING 2

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		3 PHE A  44
ASP A  13
LEU A  76
 None
MG  A 260 (-2.4A)
None
 0.78A 5uhcC-2ho4A:
undetectable		 5uhcC-2ho4A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0m PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU

(Streptococcus
pneumoniae) 		PF01895
(PhoU) 		3 PHE A 193
ASP A 195
LEU A 184
 None
ZN  A 217 (-2.7A)
None
 0.68A 5uhcC-2i0mA:
1.5		 5uhcC-2i0mA:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS) 		3 PHE A 175
ASP A 177
LEU A 450
 None
 0.45A 5uhcC-2incA:
undetectable		 5uhcC-2incA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2is5 HYPOTHETICAL PROTEIN

(Neisseria
meningitidis) 		PF05838
(Glyco_hydro_108)
PF09374
(PG_binding_3) 		3 PHE A  79
ASP A  83
LEU A 127
 None
 0.43A 5uhcC-2is5A:
undetectable		 5uhcC-2is5A:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix2 DNA POLYMERASE
SLIDING CLAMP B

(Sulfolobus
solfataricus) 		PF00705
(PCNA_N) 		3 PHE A 243
ASP A 232
LEU A 227
 None
 0.56A 5uhcC-2ix2A:
undetectable		 5uhcC-2ix2A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jss CHIMERA OF HISTONE
H2B.1 AND HISTONE
H2A.Z

(Saccharomyces
cerevisiae) 		PF00125
(Histone)
PF16211
(Histone_H2A_C) 		3 PHE A  38
ASP A  36
LEU A 145
 None
 0.40A 5uhcC-2jssA:
undetectable		 5uhcC-2jssA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2klb PUTATIVE DIFLAVIN
FLAVOPROTEIN A 3

(Nostoc sp. PCC
7120) 		no annotation 3 PHE A 114
ASP A 137
LEU A  55
 None
 0.67A 5uhcC-2klbA:
undetectable		 5uhcC-2klbA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaa R.MVAI

(Kocuria varians) 		PF15515
(MvaI_BcnI) 		3 PHE A  51
ASP A  53
LEU A  69
 None
 0.69A 5uhcC-2oaaA:
undetectable		 5uhcC-2oaaA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odm UPF0358 PROTEIN
MW0995

(Staphylococcus
aureus) 		PF07408
(DUF1507) 		3 PHE A  50
ASP A  46
LEU A  23
 None
 0.58A 5uhcC-2odmA:
undetectable		 5uhcC-2odmA:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odm UPF0358 PROTEIN
MW0995

(Staphylococcus
aureus) 		PF07408
(DUF1507) 		3 PHE A  50
ASP A  46
LEU A  75
 None
 0.76A 5uhcC-2odmA:
undetectable		 5uhcC-2odmA:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oo3 PROTEIN INVOLVED IN
CATABOLISM OF
EXTERNAL DNA

(Legionella
pneumophila) 		PF04378
(RsmJ) 		3 PHE A  13
ASP A  15
LEU A  70
 None
 0.76A 5uhcC-2oo3A:
undetectable		 5uhcC-2oo3A:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyj DNA POLYMERASE

(Bacillus virus
phi29) 		PF03175
(DNA_pol_B_2) 		3 PHE A 198
ASP A 200
LEU A 381
 None
 0.75A 5uhcC-2pyjA:
undetectable		 5uhcC-2pyjA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz9 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Vibrio cholerae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 PHE A   6
ASP A  33
LEU A  38
 None
 0.79A 5uhcC-2qz9A:
undetectable		 5uhcC-2qz9A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uy1 CLEAVAGE STIMULATION
FACTOR 77

(Encephalitozoon
cuniculi) 		PF05843
(Suf) 		3 PHE A  78
ASP A  83
LEU A 116
 None
 0.59A 5uhcC-2uy1A:
undetectable		 5uhcC-2uy1A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v1n PROTEIN KIN HOMOLOG

(Homo sapiens) 		PF10357
(Kin17_mid) 		3 PHE A  19
ASP A  17
LEU A  78
 None
 0.78A 5uhcC-2v1nA:
undetectable		 5uhcC-2v1nA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww2 ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		3 PHE A 352
ASP A 354
LEU A 470
 None
GOL  A 804 (-3.2A)
None
 0.77A 5uhcC-2ww2A:
undetectable		 5uhcC-2ww2A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww2 ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		3 PHE A 356
ASP A 411
LEU A 316
 None
 0.75A 5uhcC-2ww2A:
undetectable		 5uhcC-2ww2A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		3 PHE A 645
ASP A 647
LEU A 636
 None
 0.71A 5uhcC-2y3aA:
undetectable		 5uhcC-2y3aA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfb METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER

(Pseudomonas
putida) 		PF16591
(HBM) 		3 PHE A 243
ASP A 245
LEU A 234
 None
 0.60A 5uhcC-2yfbA:
2.9		 5uhcC-2yfbA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z00 DIHYDROOROTASE

(Thermus
thermophilus) 		PF01979
(Amidohydro_1) 		3 PHE A  51
ASP A  53
LEU A 110
 None
 0.70A 5uhcC-2z00A:
undetectable		 5uhcC-2z00A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z37 CHITINASE

(Brassica juncea) 		PF00182
(Glyco_hydro_19) 		3 PHE A 156
ASP A 154
LEU A 195
 None
 0.64A 5uhcC-2z37A:
undetectable		 5uhcC-2z37A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zie PUTATIVE
MODIFICATION
METHYLASE

(Thermus
thermophilus) 		PF01555
(N6_N4_Mtase) 		3 PHE A  72
ASP A  74
LEU A  63
 None
 0.77A 5uhcC-2zieA:
undetectable		 5uhcC-2zieA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128) 		no annotation 3 PHE A 479
ASP A 502
LEU A 374
 None
 0.64A 5uhcC-3a0fA:
undetectable		 5uhcC-3a0fA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3h ENDOGLUCANASE

(Salipaludibacillus
agaradhaerens) 		PF00150
(Cellulase) 		3 PHE A 251
ASP A 253
LEU A 242
 None
 0.74A 5uhcC-3a3hA:
undetectable		 5uhcC-3a3hA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9c TRANSLATION
INITIATION FACTOR
EIF-2B, DELTA
SUBUNIT

(Thermococcus
kodakarensis) 		PF01008
(IF-2B) 		3 PHE A 279
ASP A 280
LEU A 245
 None
 0.77A 5uhcC-3a9cA:
undetectable		 5uhcC-3a9cA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE

(Bifidobacterium
breve) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		3 PHE A 577
ASP A 676
LEU A 614
 None
 0.65A 5uhcC-3ahiA:
1.0		 5uhcC-3ahiA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		3 PHE A 577
ASP A 676
LEU A 614
 None
 0.78A 5uhcC-3ai7A:
0.8		 5uhcC-3ai7A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT A OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt)
no annotation 		3 PHE A  20
ASP B 148
LEU A  78
 None
 0.75A 5uhcC-3aqcA:
undetectable		 5uhcC-3aqcA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axi OLIGO-1,6-GLUCOSIDAS
E IMA1

(Saccharomyces
cerevisiae) 		PF00128
(Alpha-amylase) 		3 PHE A 173
ASP A 167
LEU A 185
 None
 0.76A 5uhcC-3axiA:
undetectable		 5uhcC-3axiA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c18 NUCLEOTIDYLTRANSFERA
SE-LIKE PROTEIN

(Exiguobacterium
sibiricum) 		PF14540
(NTF-like) 		3 PHE A 133
ASP A 135
LEU A 124
 None
 0.74A 5uhcC-3c18A:
undetectable		 5uhcC-3c18A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1

(Saccharomyces
cerevisiae) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		3 PHE A 286
ASP A 282
LEU A 903
 None
 0.65A 5uhcC-3cmmA:
undetectable		 5uhcC-3cmmA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP107

(Homo sapiens) 		PF04121
(Nup84_Nup100) 		3 PHE A 680
ASP A 676
LEU A 689
 None
 0.79A 5uhcC-3cqcA:
undetectable		 5uhcC-3cqcA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0j DNA POLYMERASE
SUBUNIT DELTA-2

(Homo sapiens) 		PF04042
(DNA_pol_E_B) 		3 PHE A 353
ASP A 351
LEU A 369
 None
 0.65A 5uhcC-3e0jA:
undetectable		 5uhcC-3e0jA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez9 PARA

(Salmonella
enterica) 		PF13614
(AAA_31) 		3 PHE A 260
ASP A 153
LEU A 271
 None
 0.71A 5uhcC-3ez9A:
undetectable		 5uhcC-3ez9A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI

(Monomastix sp.
OKE-1) 		PF00961
(LAGLIDADG_1) 		3 PHE A 258
ASP A 263
LEU A 141
 None
 0.76A 5uhcC-3fd2A:
1.7		 5uhcC-3fd2A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fqd 5'-3'
EXORIBONUCLEASE 2

(Schizosaccharomyces
pombe) 		PF03159
(XRN_N) 		3 PHE A 328
ASP A 324
LEU A 238
 None
 0.73A 5uhcC-3fqdA:
undetectable		 5uhcC-3fqdA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fv3 SAPP1P-SECRETED
ASPARTIC PROTEASE 1

(Candida
parapsilosis) 		PF00026
(Asp) 		3 PHE A 308
ASP A 306
LEU A 253
 None
 0.75A 5uhcC-3fv3A:
undetectable		 5uhcC-3fv3A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvb BACTERIOFERRITIN

(Brucella
abortus) 		PF00210
(Ferritin) 		3 PHE A 133
ASP A  90
LEU A 123
 None
 0.77A 5uhcC-3fvbA:
undetectable		 5uhcC-3fvbA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gju PUTATIVE
AMINOTRANSFERASE

(Mesorhizobium
japonicum) 		PF00202
(Aminotran_3) 		3 PHE A 169
ASP A 167
LEU A 181
 None
 0.69A 5uhcC-3gjuA:
undetectable		 5uhcC-3gjuA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hoc FILAMIN-A

(Homo sapiens) 		PF00307
(CH) 		3 PHE A 113
ASP A 115
LEU A 104
 None
 0.58A 5uhcC-3hocA:
undetectable		 5uhcC-3hocA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hr0 COG4

(Homo sapiens) 		PF04437
(RINT1_TIP1) 		3 PHE A 600
ASP A 602
LEU A 675
 None
 0.65A 5uhcC-3hr0A:
undetectable		 5uhcC-3hr0A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hul HOMOSERINE KINASE

(Listeria
monocytogenes) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		3 PHE A 158
ASP A 273
LEU A 164
 None
 0.75A 5uhcC-3hulA:
undetectable		 5uhcC-3hulA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ia7 CALG4

(Micromonospora
echinospora) 		PF00201
(UDPGT) 		3 PHE A   8
ASP A 108
LEU A  41
 None
 0.64A 5uhcC-3ia7A:
undetectable		 5uhcC-3ia7A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2) 		3 PHE A 777
ASP A 779
LEU A 766
 None
 0.76A 5uhcC-3ibjA:
undetectable		 5uhcC-3ibjA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Herpetosiphon
aurantiacus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 PHE A 218
ASP A 191
LEU A 291
 None
K  A 364 (-3.6A)
None
 0.77A 5uhcC-3ik4A:
undetectable		 5uhcC-3ik4A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV)
PF16004
(EFTUD2) 		3 PHE A 274
ASP A 270
LEU B 901
 None
 0.73A 5uhcC-3jb9A:
undetectable		 5uhcC-3jb9A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		3 PHE B 311
ASP B 270
LEU B 333
 None
 0.79A 5uhcC-3jcmB:
undetectable		 5uhcC-3jcmB:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4e UNCHARACTERIZED
PEPTIDASE LMO0363

(Listeria
monocytogenes) 		PF03575
(Peptidase_S51) 		3 PHE A  10
ASP A  12
LEU A 158
 None
 0.74A 5uhcC-3l4eA:
undetectable		 5uhcC-3l4eA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg5 EPI-ISOZIZAENE
SYNTHASE

(Streptomyces
coelicolor) 		no annotation 3 PHE A 297
ASP A 299
LEU A 288
 None
 0.70A 5uhcC-3lg5A:
0.4		 5uhcC-3lg5A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxr IPGB2

(Shigella
flexneri) 		PF03278
(IpaB_EvcA) 		3 PHE F  82
ASP F  80
LEU F 170
 None
 0.66A 5uhcC-3lxrF:
undetectable		 5uhcC-3lxrF:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m5u PHOSPHOSERINE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF00266
(Aminotran_5) 		3 PHE A 126
ASP A 127
LEU A 292
 None
 0.76A 5uhcC-3m5uA:
undetectable		 5uhcC-3m5uA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mbh PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE

(Bacteroides
thetaiotaomicron) 		PF08543
(Phos_pyr_kin) 		3 PHE A 226
ASP A 224
LEU A 270
 None
PXL  A 400 (-2.4A)
None
 0.73A 5uhcC-3mbhA:
undetectable		 5uhcC-3mbhA:
12.77