SIMILAR PATTERNS OF AMINO ACIDS FOR 5UHC_C_RFPC1201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pss PHOTOSYNTHETIC
REACTION CENTER

(Rhodobacter
sphaeroides) 		PF00124
(Photo_RC) 		5 LEU L 193
HIS L 230
ASN M  44
ILE L 224
ARG L 231
 U10  L 272 (-3.8A)
FE  M 302 (-3.4A)
None
U10  L 272 (-4.4A)
None
 1.23A 5uhcC-1pssL:
1.5		 5uhcC-1pssL:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go9 INSULINASE FAMILY
PROTEASE

(Yersinia pestis) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 GLN A 331
GLN A 407
PRO A 112
ILE A 115
ARG A  60
 None
 1.10A 5uhcC-3go9A:
0.0		 5uhcC-3go9A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 GLN B 412
HIS B 425
ARG B 428
PRO B 459
ASN B 463
 None
 0.92A 5uhcC-3hkzB:
21.7		 5uhcC-3hkzB:
29.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qz4 ENDO-1,4-BETA-XYLANA
SE D

(Bacteroides
thetaiotaomicron) 		PF04616
(Glyco_hydro_43) 		5 LEU A 303
ARG A 297
PRO A 331
ASN A 269
ILE A 274
 None
 1.31A 5uhcC-3qz4A:
1.6		 5uhcC-3qz4A:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t3o METAL DEPENDENT
HYDROLASE

(Thermus
thermophilus) 		PF07521
(RMMBL)
PF12706
(Lactamase_B_2) 		5 GLN A 404
LEU A 395
HIS A 169
ASN A 426
HIS A  75
 None
None
None
None
ZN  A 600 (-4.8A)
 1.49A 5uhcC-3t3oA:
2.3		 5uhcC-3t3oA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efc ADENYLOSUCCINATE
LYASE

(Trypanosoma
brucei) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		5 GLN A 257
LEU A 254
ILE A 146
ARG A  50
HIS A 133
 None
 1.36A 5uhcC-4efcA:
1.6		 5uhcC-4efcA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mou ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Paenarthrobacter
aurescens) 		PF00378
(ECH_1) 		5 GLN A  51
LEU A  48
ILE A  19
ARG A 210
HIS A 218
 None
 1.20A 5uhcC-4mouA:
undetectable		 5uhcC-4mouA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 GLN B 425
HIS B 438
ARG B 441
PRO B 472
ASN B 476
 None
 1.05A 5uhcC-4qiwB:
28.5		 5uhcC-4qiwB:
28.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nws SAACMM

(Streptomyces
antibioticus) 		no annotation 5 LEU A 262
ARG A 195
PRO A 189
ILE A 188
ARG A 229
 None
 1.40A 5uhcC-5nwsA:
0.0		 5uhcC-5nwsA:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oon UNDECAPRENYL-DIPHOSP
HATASE

(Escherichia
coli) 		no annotation 5 LEU A 246
SER A 193
ILE A 179
ARG A 261
HIS A  30
 None
None
None
None
OLC  A 304 (-4.5A)
 1.42A 5uhcC-5oonA:
undetectable		 5uhcC-5oonA:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tev TRYPTOPHAN--TRNA
LIGASE

(Neisseria
gonorrhoeae) 		PF00579
(tRNA-synt_1b) 		5 LEU A 141
HIS A 163
PRO A 185
ILE A 146
HIS A 110
 None
 1.49A 5uhcC-5tevA:
undetectable		 5uhcC-5tevA:
14.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		10 GLN C 426
LEU C 427
GLN C 429
HIS C 442
ARG C 445
SER C 447
PRO C 480
ASN C 484
ILE C 488
ARG C 604
 None
 1.29A 5uhcC-5tw1C:
49.5		 5uhcC-5tw1C:
91.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		10 GLN C 426
LEU C 427
GLN C 429
HIS C 442
ARG C 445
SER C 447
PRO C 480
ASN C 484
ILE C 488
HIS C 671
 None
 0.79A 5uhcC-5tw1C:
49.5		 5uhcC-5tw1C:
91.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		8 HIS C 442
ARG C 445
SER C 447
ARG C 456
PRO C 480
ASN C 484
ILE C 488
HIS C 671
 None
 1.15A 5uhcC-5tw1C:
49.5		 5uhcC-5tw1C:
91.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k ACTF

(Rhodothermus
marinus) 		no annotation 5 LEU F 179
GLN F 195
HIS F  88
ARG F 196
ARG F  91
 None
 1.48A 5uhcC-6f0kF:
0.0		 5uhcC-6f0kF:
5.86