SIMILAR PATTERNS OF AMINO ACIDS FOR 5UHB_C_RFPC1201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1omo ALANINE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF02423
(OCD_Mu_crystall) 		5 LEU A 293
GLN A 296
SER A 290
ASN A 214
ILE A 216
 LEU  A 293 ( 0.6A)
GLN  A 296 ( 0.6A)
SER  A 290 (-0.0A)
ASN  A 214 ( 0.6A)
ILE  A 216 (-0.7A)
 1.21A 5uhbC-1omoA:
2.1		 5uhbC-1omoA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pss PHOTOSYNTHETIC
REACTION CENTER

(Rhodobacter
sphaeroides) 		PF00124
(Photo_RC) 		5 LEU L 193
HIS L 230
ASN M  44
ILE L 224
ARG L 231
 U10  L 272 (-3.8A)
FE  M 302 (-3.4A)
None
U10  L 272 (-4.4A)
None
 1.31A 5uhbC-1pssL:
undetectable		 5uhbC-1pssL:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwt PROTEIN PUF4

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		5 GLN A 618
LEU A 621
ASN A 646
ILE A 643
HIS A 569
 None
 1.36A 5uhbC-3bwtA:
0.0		 5uhbC-3bwtA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go9 INSULINASE FAMILY
PROTEASE

(Yersinia pestis) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 GLN A 331
GLN A 407
PRO A 112
ILE A 115
ARG A  60
 None
 1.11A 5uhbC-3go9A:
0.0		 5uhbC-3go9A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 GLN B 412
HIS B 425
ARG B 428
PRO B 459
ASN B 463
 None
 0.81A 5uhbC-3hkzB:
21.7		 5uhbC-3hkzB:
29.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qz4 ENDO-1,4-BETA-XYLANA
SE D

(Bacteroides
thetaiotaomicron) 		PF04616
(Glyco_hydro_43) 		5 LEU A 303
ARG A 297
PRO A 331
ASN A 269
ILE A 274
 None
 1.25A 5uhbC-3qz4A:
1.5		 5uhbC-3qz4A:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3srz TOXIN A

(Clostridioides
difficile) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		5 LEU A 507
GLN A 509
ARG A 272
ASN A 383
ILE A 374
 None
None
UPG  A 556 (-2.9A)
UPG  A 556 (-3.7A)
None
 1.39A 5uhbC-3srzA:
1.4		 5uhbC-3srzA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mou ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Paenarthrobacter
aurescens) 		PF00378
(ECH_1) 		5 GLN A  51
LEU A  48
ILE A  19
ARG A 210
HIS A 218
 None
 1.18A 5uhbC-4mouA:
0.1		 5uhbC-4mouA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s28 PHOSPHOMETHYLPYRIMID
INE SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01964
(ThiC_Rad_SAM) 		5 GLN A 437
LEU A 440
GLN A 439
PRO A 453
ILE A 474
 None
 1.32A 5uhbC-4s28A:
undetectable		 5uhbC-4s28A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN

(Escherichia
virus T4;
Homo sapiens;
Mus musculus) 		PF00001
(7tm_1)
PF00339
(Arrestin_N)
PF00959
(Phage_lysozyme)
PF02752
(Arrestin_C)
PF10413
(Rhodopsin_N) 		5 GLN A2188
LEU A2210
ARG A2355
PRO A2182
ILE A2214
 None
 1.41A 5uhbC-4zwjA:
1.5		 5uhbC-4zwjA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nws SAACMM

(Streptomyces
antibioticus) 		no annotation 5 LEU A 262
ARG A 195
PRO A 189
ILE A 188
ARG A 229
 None
 1.48A 5uhbC-5nwsA:
undetectable		 5uhbC-5nwsA:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oon UNDECAPRENYL-DIPHOSP
HATASE

(Escherichia
coli) 		no annotation 5 LEU A 246
SER A 193
ILE A 179
ARG A 261
HIS A  30
 None
None
None
None
OLC  A 304 (-4.5A)
 1.45A 5uhbC-5oonA:
1.1		 5uhbC-5oonA:
5.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		10 GLN C 426
LEU C 427
GLN C 429
HIS C 442
ARG C 445
SER C 447
PRO C 480
ASN C 484
ILE C 488
ARG C 604
 None
 1.37A 5uhbC-5tw1C:
51.1		 5uhbC-5tw1C:
91.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		10 GLN C 426
LEU C 427
GLN C 429
HIS C 442
ARG C 445
SER C 447
PRO C 480
ASN C 484
ILE C 488
HIS C 671
 None
 0.82A 5uhbC-5tw1C:
51.1		 5uhbC-5tw1C:
91.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		8 HIS C 442
ARG C 445
SER C 447
ARG C 456
PRO C 480
ASN C 484
ILE C 488
HIS C 671
 None
 1.12A 5uhbC-5tw1C:
51.1		 5uhbC-5tw1C:
91.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 GLN B 474
HIS B 487
ARG B 490
ARG B 497
PRO B 521
 A  P   7 ( 3.9A)
None
G  P   8 ( 4.7A)
A  P   7 ( 4.9A)
G  P   8 ( 4.9A)
 1.02A 5uhbC-5xogB:
22.6		 5uhbC-5xogB:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aoa T-FIMBRIN

(Homo sapiens) 		PF00307
(CH) 		3 PHE A 369
ASP A 357
LEU A 231
 PHE  A 369 ( 1.3A)
ASP  A 357 ( 0.6A)
LEU  A 231 ( 0.6A)
 0.77A 5uhbC-1aoaA:
0.0		 5uhbC-1aoaA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cc1 HYDROGENASE (LARGE
SUBUNIT)

(Desulfomicrobium
baculatum) 		PF00374
(NiFeSe_Hases) 		3 PHE L 239
ASP L 237
LEU L 468
 None
 0.76A 5uhbC-1cc1L:
0.0		 5uhbC-1cc1L:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dmg RIBOSOMAL PROTEIN L4

(Thermotoga
maritima) 		PF00573
(Ribosomal_L4) 		3 PHE A 203
ASP A  38
LEU A 108
 None
 0.65A 5uhbC-1dmgA:
0.0		 5uhbC-1dmgA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fq9 FIBROBLAST GROWTH
FACTOR 2

(Homo sapiens) 		PF00167
(FGF) 		3 PHE A  17
ASP A  19
LEU A 140
 None
 0.73A 5uhbC-1fq9A:
undetectable		 5uhbC-1fq9A:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlg LIPASE, GASTRIC

(Homo sapiens) 		PF00561
(Abhydrolase_1) 		3 PHE A 241
ASP A 247
LEU A 222
 None
 0.59A 5uhbC-1hlgA:
0.0		 5uhbC-1hlgA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jgc BACTERIOFERRITIN

(Rhodobacter
capsulatus) 		PF00210
(Ferritin) 		3 PHE A 133
ASP A  90
LEU A 123
 None
 0.71A 5uhbC-1jgcA:
0.0		 5uhbC-1jgcA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji6 PESTICIDIAL CRYSTAL
PROTEIN CRY3BB

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 PHE A 286
ASP A 288
LEU A  88
 None
 0.60A 5uhbC-1ji6A:
0.0		 5uhbC-1ji6A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jjv DEPHOSPHO-COA KINASE

(Haemophilus
influenzae) 		PF01121
(CoaE) 		3 PHE A 110
ASP A  31
LEU A  25
 None
 0.68A 5uhbC-1jjvA:
0.7		 5uhbC-1jjvA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jne IMAGINAL DISC GROWTH
FACTOR-2

(Drosophila
melanogaster) 		PF00704
(Glyco_hydro_18) 		3 PHE A 394
ASP A   9
LEU A 316
 None
 0.75A 5uhbC-1jneA:
0.0		 5uhbC-1jneA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jod OLFACTORY MARKER
PROTEIN

(Mus musculus) 		PF06554
(Olfactory_mark) 		3 PHE A 241
ASP A 118
LEU A 145
 None
ZN  A 304 (-3.0A)
ZN  A 302 ( 4.8A)
 0.73A 5uhbC-1jodA:
undetectable		 5uhbC-1jodA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kn5 TRANSCRIPTION
REGULATORY PROTEIN
ADR6

(Saccharomyces
cerevisiae) 		PF01388
(ARID) 		3 PHE A  48
ASP A  52
LEU A  38
 None
 0.77A 5uhbC-1kn5A:
undetectable		 5uhbC-1kn5A:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8p CYSTATHIONINE
GAMMA-LYASE

(Saccharomyces
cerevisiae) 		PF01053
(Cys_Met_Meta_PP) 		3 PHE A 364
ASP A 365
LEU A 342
 None
 0.81A 5uhbC-1n8pA:
undetectable		 5uhbC-1n8pA:
16.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o51 HYPOTHETICAL PROTEIN
TM0021

(Thermotoga
maritima) 		PF02641
(DUF190) 		3 PHE A  20
ASP A  12
LEU A  79
 None
 0.69A 5uhbC-1o51A:
undetectable		 5uhbC-1o51A:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olx 2-OXOISOVALERATE
DEHYDROGENASE BETA
SUBUNIT

(Homo sapiens) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 PHE B 324
ASP B 328
LEU B 283
 None
 0.79A 5uhbC-1olxB:
undetectable		 5uhbC-1olxB:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyw ATP-DEPENDENT DNA
HELICASE

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		3 PHE A 158
ASP A 157
LEU A 368
 None
 0.62A 5uhbC-1oywA:
undetectable		 5uhbC-1oywA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1reg T4 REGA

(Escherichia
virus T4) 		PF01818
(Translat_reg) 		3 PHE X  93
ASP X  96
LEU X  78
 None
 0.81A 5uhbC-1regX:
undetectable		 5uhbC-1regX:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5k AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE

(Salmonella
enterica) 		PF00583
(Acetyltransf_1) 		3 PHE A  46
ASP A  59
LEU A  84
 None
 0.66A 5uhbC-1s5kA:
undetectable		 5uhbC-1s5kA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfj 3-DEHYDROQUINATE
DEHYDRATASE

(Staphylococcus
aureus) 		PF01487
(DHquinase_I) 		3 PHE A 181
ASP A 183
LEU A 172
 None
 0.69A 5uhbC-1sfjA:
undetectable		 5uhbC-1sfjA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t34 ATRIAL NATRIURETIC
PEPTIDE RECEPTOR A

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		3 PHE A 388
ASP A 382
LEU A 254
 None
 0.77A 5uhbC-1t34A:
1.2		 5uhbC-1t34A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1te7 HYPOTHETICAL UPF0267
PROTEIN YQFB

(Escherichia
coli) 		PF04266
(ASCH) 		3 PHE A  44
ASP A  46
LEU A  17
 None
 0.66A 5uhbC-1te7A:
undetectable		 5uhbC-1te7A:
6.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tk1 COPROPORPHYRINOGEN
III OXIDASE

(Saccharomyces
cerevisiae) 		PF01218
(Coprogen_oxidas) 		3 PHE A 235
ASP A 233
LEU A 185
 None
 0.69A 5uhbC-1tk1A:
2.4		 5uhbC-1tk1A:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkl COPROPORPHYRINOGEN
III OXIDASE

(Saccharomyces
cerevisiae) 		PF01218
(Coprogen_oxidas) 		3 PHE A 235
ASP A 233
LEU A 185
 None
 0.68A 5uhbC-1tklA:
undetectable		 5uhbC-1tklA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tly NUCLEOSIDE-SPECIFIC
CHANNEL-FORMING
PROTEIN TSX

(Escherichia
coli) 		PF03502
(Channel_Tsx) 		3 PHE A  48
ASP A  46
LEU A  94
 None
 0.68A 5uhbC-1tlyA:
1.7		 5uhbC-1tlyA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uls PUTATIVE
3-OXOACYL-ACYL
CARRIER PROTEIN
REDUCTASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		3 PHE A  92
ASP A  90
LEU A  98
 None
 0.73A 5uhbC-1ulsA:
undetectable		 5uhbC-1ulsA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxo YDEN PROTEIN

(Bacillus
subtilis) 		PF06821
(Ser_hydrolase) 		3 PHE A 142
ASP A 136
LEU A 106
 None
 0.60A 5uhbC-1uxoA:
undetectable		 5uhbC-1uxoA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT

(Thermotoga
maritima) 		PF01039
(Carboxyl_trans) 		3 PHE A 345
ASP A 181
LEU A 515
 None
 0.72A 5uhbC-1vrgA:
undetectable		 5uhbC-1vrgA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w3i 2-KETO-3-DEOXY
GLUCONATE ALDOLASE

(Sulfolobus
solfataricus) 		PF00701
(DHDPS) 		3 PHE A 265
ASP A 268
LEU A 248
 None
 0.80A 5uhbC-1w3iA:
undetectable		 5uhbC-1w3iA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wf0 TAR DNA-BINDING
PROTEIN-43

(Homo sapiens) 		PF00076
(RRM_1) 		3 PHE A  36
ASP A  34
LEU A  58
 None
 0.67A 5uhbC-1wf0A:
undetectable		 5uhbC-1wf0A:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1n 4-ALPHA-GLUCANOTRANS
FERASE

(Solanum
tuberosum) 		PF02446
(Glyco_hydro_77) 		3 PHE A 318
ASP A 316
LEU A  32
 None
 0.77A 5uhbC-1x1nA:
undetectable		 5uhbC-1x1nA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfj CONSERVED
HYPOTHETICAL PROTEIN

(Caulobacter
vibrioides) 		PF02578
(Cu-oxidase_4) 		3 PHE A 243
ASP A 247
LEU A 253
 None
 0.76A 5uhbC-1xfjA:
undetectable		 5uhbC-1xfjA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xl3 PROTEIN TYPE A
SECRETION CONTROL
PROTEIN

(Yersinia pestis) 		PF07201
(HrpJ)
PF09059
(TyeA) 		3 PHE A 223
ASP A 227
LEU C   5
 None
 0.63A 5uhbC-1xl3A:
undetectable		 5uhbC-1xl3A:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT

(Streptomyces
coelicolor) 		PF01039
(Carboxyl_trans) 		3 PHE A 359
ASP A 192
LEU A 530
 None
 0.80A 5uhbC-1xnyA:
undetectable		 5uhbC-1xnyA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7x MAJOR VAULT PROTEIN

(Homo sapiens) 		PF01505
(Vault) 		3 PHE A 101
ASP A  76
LEU A  89
 None
 0.76A 5uhbC-1y7xA:
undetectable		 5uhbC-1y7xA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yif BETA-1,4-XYLOSIDASE

(Bacillus
subtilis) 		PF04616
(Glyco_hydro_43) 		3 PHE A 402
ASP A 425
LEU A 420
 None
 0.80A 5uhbC-1yifA:
undetectable		 5uhbC-1yifA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzf LIPASE/ACYLHYDROLASE

(Enterococcus
faecalis) 		PF13472
(Lipase_GDSL_2) 		3 PHE A   7
ASP A   9
LEU A  27
 None
 0.70A 5uhbC-1yzfA:
undetectable		 5uhbC-1yzfA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzf LIPASE/ACYLHYDROLASE

(Enterococcus
faecalis) 		PF13472
(Lipase_GDSL_2) 		3 PHE A   7
ASP A   9
LEU A 181
 None
 0.79A 5uhbC-1yzfA:
undetectable		 5uhbC-1yzfA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7c CHORIONIC
SOMATOMAMMOTROPIN
HORMONE

(Homo sapiens) 		PF00103
(Hormone_1) 		3 PHE A 176
ASP A 171
LEU A  15
 None
 0.75A 5uhbC-1z7cA:
undetectable		 5uhbC-1z7cA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrt CYTOCHROME B

(Rhodobacter
capsulatus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		3 PHE C 369
ASP C 373
LEU C 349
 None
 0.70A 5uhbC-1zrtC:
undetectable		 5uhbC-1zrtC:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8x DIHYDROLIPOYL
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 PHE A  62
ASP A  65
LEU A  53
 None
 0.75A 5uhbC-2a8xA:
undetectable		 5uhbC-2a8xA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS

(Bacillus
subtilis) 		PF02898
(NO_synthase) 		3 PHE A 163
ASP A 141
LEU A 168
 None
 0.79A 5uhbC-2an2A:
undetectable		 5uhbC-2an2A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dae KIAA0733 PROTEIN

(Homo sapiens) 		PF02845
(CUE) 		3 PHE A  63
ASP A  65
LEU A  47
 None
 0.71A 5uhbC-2daeA:
undetectable		 5uhbC-2daeA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ea3 CHYMOTRYPSIN

(Cellulomonas
bogoriensis) 		PF00089
(Trypsin) 		3 PHE A 166
ASP A  56
LEU A 178
 None
 0.79A 5uhbC-2ea3A:
undetectable		 5uhbC-2ea3A:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1z UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF00443
(UCH)
PF00917
(MATH) 		3 PHE A 324
ASP A 349
LEU A 396
 None
 0.64A 5uhbC-2f1zA:
undetectable		 5uhbC-2f1zA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9b CALBINDIN

(Rattus
norvegicus) 		PF13405
(EF-hand_6)
PF13499
(EF-hand_7) 		3 PHE A 117
ASP A 155
LEU A 127
 None
 0.72A 5uhbC-2g9bA:
undetectable		 5uhbC-2g9bA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9i F420-0:GAMMA-GLUTAMY
L LIGASE

(Archaeoglobus
fulgidus) 		PF01996
(F420_ligase) 		3 PHE A 163
ASP A 150
LEU A  36
 None
 0.81A 5uhbC-2g9iA:
undetectable		 5uhbC-2g9iA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ge3 PROBABLE
ACETYLTRANSFERASE

(Agrobacterium
tumefaciens) 		PF00583
(Acetyltransf_1) 		3 PHE A  61
ASP A  74
LEU A  94
 None
 0.80A 5uhbC-2ge3A:
1.8		 5uhbC-2ge3A:
9.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gr9 PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1

(Homo sapiens) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		3 PHE A 182
ASP A 186
LEU A 253
 None
 0.78A 5uhbC-2gr9A:
undetectable		 5uhbC-2gr9A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtl HEMOGLOBIN LINKER
CHAIN L1

(Lumbricus
terrestris) 		PF00057
(Ldl_recept_a)
PF16915
(Eryth_link_C) 		3 PHE M 196
ASP M 205
LEU M  50
 None
 0.79A 5uhbC-2gtlM:
2.3		 5uhbC-2gtlM:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gz6 N-ACETYL-D-GLUCOSAMI
NE 2-EPIMERASE

(Anabaena sp.
CH1) 		PF07221
(GlcNAc_2-epim) 		3 PHE A  36
ASP A  49
LEU A 360
 None
 0.78A 5uhbC-2gz6A:
undetectable		 5uhbC-2gz6A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0m PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU

(Streptococcus
pneumoniae) 		PF01895
(PhoU) 		3 PHE A 193
ASP A 195
LEU A 184
 None
ZN  A 217 (-2.7A)
None
 0.80A 5uhbC-2i0mA:
undetectable		 5uhbC-2i0mA:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS) 		3 PHE A 175
ASP A 177
LEU A 450
 None
 0.42A 5uhbC-2incA:
undetectable		 5uhbC-2incA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2is5 HYPOTHETICAL PROTEIN

(Neisseria
meningitidis) 		PF05838
(Glyco_hydro_108)
PF09374
(PG_binding_3) 		3 PHE A  79
ASP A  83
LEU A 127
 None
 0.56A 5uhbC-2is5A:
undetectable		 5uhbC-2is5A:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iut DNA TRANSLOCASE FTSK

(Pseudomonas
aeruginosa) 		PF01580
(FtsK_SpoIIIE) 		3 PHE A 597
ASP A 599
LEU A 721
 None
 0.74A 5uhbC-2iutA:
2.2		 5uhbC-2iutA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix2 DNA POLYMERASE
SLIDING CLAMP B

(Sulfolobus
solfataricus) 		PF00705
(PCNA_N) 		3 PHE A 243
ASP A 232
LEU A 227
 None
 0.57A 5uhbC-2ix2A:
undetectable		 5uhbC-2ix2A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Saccharomyces
cerevisiae) 		PF00156
(Pribosyltran) 		3 PHE A 154
ASP A 110
LEU A  99
 None
5GP  A 300 (-3.4A)
None
 0.76A 5uhbC-2jkyA:
undetectable		 5uhbC-2jkyA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Saccharomyces
cerevisiae) 		PF00156
(Pribosyltran) 		3 PHE A 154
ASP A 110
LEU A 101
 None
5GP  A 300 (-3.4A)
None
 0.80A 5uhbC-2jkyA:
undetectable		 5uhbC-2jkyA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jss CHIMERA OF HISTONE
H2B.1 AND HISTONE
H2A.Z

(Saccharomyces
cerevisiae) 		PF00125
(Histone)
PF16211
(Histone_H2A_C) 		3 PHE A  38
ASP A  36
LEU A 145
 None
 0.48A 5uhbC-2jssA:
1.7		 5uhbC-2jssA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2klb PUTATIVE DIFLAVIN
FLAVOPROTEIN A 3

(Nostoc sp. PCC
7120) 		no annotation 3 PHE A 114
ASP A 137
LEU A  55
 None
 0.75A 5uhbC-2klbA:
undetectable		 5uhbC-2klbA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaa R.MVAI

(Kocuria varians) 		PF15515
(MvaI_BcnI) 		3 PHE A  51
ASP A  53
LEU A  69
 None
 0.66A 5uhbC-2oaaA:
undetectable		 5uhbC-2oaaA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odm UPF0358 PROTEIN
MW0995

(Staphylococcus
aureus) 		PF07408
(DUF1507) 		3 PHE A  50
ASP A  46
LEU A  23
 None
 0.62A 5uhbC-2odmA:
undetectable		 5uhbC-2odmA:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oo3 PROTEIN INVOLVED IN
CATABOLISM OF
EXTERNAL DNA

(Legionella
pneumophila) 		PF04378
(RsmJ) 		3 PHE A  13
ASP A  15
LEU A  70
 None
 0.72A 5uhbC-2oo3A:
undetectable		 5uhbC-2oo3A:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2c CASPASE-2

(Homo sapiens) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		3 PHE P 150
ASP P 155
LEU P 119
 None
 0.77A 5uhbC-2p2cP:
undetectable		 5uhbC-2p2cP:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q24 PUTATIVE TETR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		3 PHE A  97
ASP A  99
LEU A  84
 None
 0.77A 5uhbC-2q24A:
undetectable		 5uhbC-2q24A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz9 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Vibrio cholerae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 PHE A   6
ASP A  33
LEU A  38
 None
 0.71A 5uhbC-2qz9A:
undetectable		 5uhbC-2qz9A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uy1 CLEAVAGE STIMULATION
FACTOR 77

(Encephalitozoon
cuniculi) 		PF05843
(Suf) 		3 PHE A  78
ASP A  83
LEU A 116
 None
 0.56A 5uhbC-2uy1A:
undetectable		 5uhbC-2uy1A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v1n PROTEIN KIN HOMOLOG

(Homo sapiens) 		PF10357
(Kin17_mid) 		3 PHE A  19
ASP A  17
LEU A  78
 None
 0.77A 5uhbC-2v1nA:
undetectable		 5uhbC-2v1nA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww2 ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		3 PHE A 356
ASP A 411
LEU A 316
 None
 0.77A 5uhbC-2ww2A:
undetectable		 5uhbC-2ww2A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0e UDP-GLUCOSE
DEHYDROGENASE

(Burkholderia
cepacia) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		3 PHE A 330
ASP A 335
LEU A 373
 UGA  A 501 (-4.7A)
None
None
 0.79A 5uhbC-2y0eA:
undetectable		 5uhbC-2y0eA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		3 PHE A 645
ASP A 647
LEU A 636
 None
 0.79A 5uhbC-2y3aA:
2.1		 5uhbC-2y3aA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfb METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER

(Pseudomonas
putida) 		PF16591
(HBM) 		3 PHE A 243
ASP A 245
LEU A 234
 None
 0.71A 5uhbC-2yfbA:
3.4		 5uhbC-2yfbA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z00 DIHYDROOROTASE

(Thermus
thermophilus) 		PF01979
(Amidohydro_1) 		3 PHE A  51
ASP A  53
LEU A 110
 None
 0.78A 5uhbC-2z00A:
undetectable		 5uhbC-2z00A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z37 CHITINASE

(Brassica juncea) 		PF00182
(Glyco_hydro_19) 		3 PHE A 156
ASP A 154
LEU A 195
 None
 0.73A 5uhbC-2z37A:
undetectable		 5uhbC-2z37A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128) 		no annotation 3 PHE A 479
ASP A 502
LEU A 374
 None
 0.66A 5uhbC-3a0fA:
undetectable		 5uhbC-3a0fA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3h ENDOGLUCANASE

(Salipaludibacillus
agaradhaerens) 		PF00150
(Cellulase) 		3 PHE A 251
ASP A 253
LEU A 242
 None
 0.79A 5uhbC-3a3hA:
undetectable		 5uhbC-3a3hA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9c TRANSLATION
INITIATION FACTOR
EIF-2B, DELTA
SUBUNIT

(Thermococcus
kodakarensis) 		PF01008
(IF-2B) 		3 PHE A 279
ASP A 280
LEU A 245
 None
 0.75A 5uhbC-3a9cA:
undetectable		 5uhbC-3a9cA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE

(Bifidobacterium
breve) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		3 PHE A 577
ASP A 676
LEU A 614
 None
 0.56A 5uhbC-3ahiA:
1.8		 5uhbC-3ahiA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		3 PHE A 577
ASP A 676
LEU A 614
 None
 0.65A 5uhbC-3ai7A:
1.2		 5uhbC-3ai7A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT A OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt)
no annotation 		3 PHE A  20
ASP B 148
LEU A  78
 None
 0.71A 5uhbC-3aqcA:
undetectable		 5uhbC-3aqcA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axi OLIGO-1,6-GLUCOSIDAS
E IMA1

(Saccharomyces
cerevisiae) 		PF00128
(Alpha-amylase) 		3 PHE A 173
ASP A 167
LEU A 185
 None
 0.77A 5uhbC-3axiA:
undetectable		 5uhbC-3axiA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b95 EUCHROMATIC
HISTONE-LYSINE
N-METHYLTRANSFERASE
1

(Homo sapiens) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		3 PHE A 884
ASP A 909
LEU A 928
 None
 0.81A 5uhbC-3b95A:
undetectable		 5uhbC-3b95A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1

(Saccharomyces
cerevisiae) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		3 PHE A 286
ASP A 282
LEU A 903
 None
 0.71A 5uhbC-3cmmA:
undetectable		 5uhbC-3cmmA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP107

(Homo sapiens) 		PF04121
(Nup84_Nup100) 		3 PHE A 680
ASP A 676
LEU A 689
 None
 0.80A 5uhbC-3cqcA:
undetectable		 5uhbC-3cqcA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0j DNA POLYMERASE
SUBUNIT DELTA-2

(Homo sapiens) 		PF04042
(DNA_pol_E_B) 		3 PHE A 353
ASP A 351
LEU A 369
 None
 0.76A 5uhbC-3e0jA:
undetectable		 5uhbC-3e0jA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		3 PHE A 302
ASP A 280
LEU A 307
 None
 0.81A 5uhbC-3e7gA:
undetectable		 5uhbC-3e7gA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez9 PARA

(Salmonella
enterica) 		PF13614
(AAA_31) 		3 PHE A 260
ASP A 153
LEU A 271
 None
 0.60A 5uhbC-3ez9A:
undetectable		 5uhbC-3ez9A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI

(Monomastix sp.
OKE-1) 		PF00961
(LAGLIDADG_1) 		3 PHE A  55
ASP A  60
LEU A 344
 None
 0.78A 5uhbC-3fd2A:
2.2		 5uhbC-3fd2A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI

(Monomastix sp.
OKE-1) 		PF00961
(LAGLIDADG_1) 		3 PHE A 258
ASP A 263
LEU A 141
 None
 0.75A 5uhbC-3fd2A:
2.2		 5uhbC-3fd2A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fv3 SAPP1P-SECRETED
ASPARTIC PROTEASE 1

(Candida
parapsilosis) 		PF00026
(Asp) 		3 PHE A 308
ASP A 306
LEU A 253
 None
 0.76A 5uhbC-3fv3A:
undetectable		 5uhbC-3fv3A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvb BACTERIOFERRITIN

(Brucella
abortus) 		PF00210
(Ferritin) 		3 PHE A 133
ASP A  90
LEU A 123
 None
 0.74A 5uhbC-3fvbA:
undetectable		 5uhbC-3fvbA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gju PUTATIVE
AMINOTRANSFERASE

(Mesorhizobium
japonicum) 		PF00202
(Aminotran_3) 		3 PHE A 169
ASP A 167
LEU A 181
 None
 0.75A 5uhbC-3gjuA:
undetectable		 5uhbC-3gjuA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwb PEPTIDASE M16
INACTIVE DOMAIN
FAMILY PROTEIN

(Pseudomonas
protegens) 		PF05193
(Peptidase_M16_C) 		3 PHE A  36
ASP A 204
LEU A  12
 None
 0.80A 5uhbC-3gwbA:
undetectable		 5uhbC-3gwbA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhr HUMAN GROWTH HORMONE

(Homo sapiens) 		PF00103
(Hormone_1) 		3 PHE A 176
ASP A 171
LEU A  15
 None
 0.78A 5uhbC-3hhrA:
undetectable		 5uhbC-3hhrA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hoc FILAMIN-A

(Homo sapiens) 		PF00307
(CH) 		3 PHE A 113
ASP A 115
LEU A 104
 None
 0.69A 5uhbC-3hocA:
undetectable		 5uhbC-3hocA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hr0 COG4

(Homo sapiens) 		PF04437
(RINT1_TIP1) 		3 PHE A 600
ASP A 602
LEU A 675
 None
 0.72A 5uhbC-3hr0A:
undetectable		 5uhbC-3hr0A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hu5 ISOCHORISMATASE
FAMILY PROTEIN

(Desulfovibrio
vulgaris) 		PF00857
(Isochorismatase) 		3 PHE A 148
ASP A 153
LEU A  54
 None
 0.75A 5uhbC-3hu5A:
undetectable		 5uhbC-3hu5A:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hul HOMOSERINE KINASE

(Listeria
monocytogenes) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		3 PHE A 158
ASP A 273
LEU A 164
 None
 0.75A 5uhbC-3hulA:
undetectable		 5uhbC-3hulA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ia7 CALG4

(Micromonospora
echinospora) 		PF00201
(UDPGT) 		3 PHE A   8
ASP A 108
LEU A  41
 None
 0.69A 5uhbC-3ia7A:
undetectable		 5uhbC-3ia7A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Herpetosiphon
aurantiacus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 PHE A 218
ASP A 191
LEU A 291
 None
K  A 364 (-3.6A)
None
 0.75A 5uhbC-3ik4A:
undetectable		 5uhbC-3ik4A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV)
PF16004
(EFTUD2) 		3 PHE A 274
ASP A 270
LEU B 901
 None
 0.73A 5uhbC-3jb9A:
undetectable		 5uhbC-3jb9A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		3 PHE B 311
ASP B 270
LEU B 333
 None
 0.70A 5uhbC-3jcmB:
undetectable		 5uhbC-3jcmB:
18.02