SIMILAR PATTERNS OF AMINO ACIDS FOR 5UH6_C_RFPC1201_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvv GLUTAMATE--CYSTEINE
LIGASE

(Saccharomyces
cerevisiae) 		PF03074
(GCS) 		4 ARG A 234
PHE A 237
LEU A 246
PRO A 336
 None
 1.40A 5uh6C-3lvvA:
0.0		 5uh6C-3lvvA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iop C-TYPE LECTIN DOMAIN
FAMILY 2 MEMBER A
KILLER CELL
LECTIN-LIKE RECEPTOR
SUBFAMILY F MEMBER 2

(Homo sapiens) 		PF00059
(Lectin_C) 		4 ARG A 158
PHE A 160
LEU B 147
PRO B 158
 None
NAG  A 204 (-4.2A)
None
None
 1.47A 5uh6C-4iopA:
0.0		 5uh6C-4iopA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvc ABC TRANSPORTER
ATP-BINDING PROTEIN

(Geobacillus
kaustophilus) 		PF00005
(ABC_tran) 		4 ARG A 176
PHE A 149
LEU A 128
PRO A 132
 None
 1.42A 5uh6C-4rvcA:
0.0		 5uh6C-4rvcA:
13.06