SIMILAR PATTERNS OF AMINO ACIDS FOR 5UH6_C_RFPC1201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 GLN A 108
LEU A 109
ASP A 118
ILE A  62
ARG A 119
 None
 1.49A 5uh6C-1v0bA:
0.1		 5uh6C-1v0bA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xls ORPHAN NUCLEAR
RECEPTOR NR1I3
RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens;
Mus musculus) 		PF00104
(Hormone_recep) 		5 GLN E 245
LEU E 249
ASP A 379
HIS E 254
ILE E 332
 None
 1.48A 5uh6C-1xlsE:
undetectable		 5uh6C-1xlsE:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3b GLUCOSE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF01547
(SBP_bac_1) 		5 LEU A 298
ASP A 278
ASN A  35
ILE A   5
HIS A 119
 None
GLC  A2605 (-2.7A)
None
None
GLC  A2605 ( 4.7A)
 1.25A 5uh6C-2b3bA:
0.0		 5uh6C-2b3bA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btj GREEN TO RED
PHOTOCONVERTIBLE
GPF-LIKE PROTEIN
EOSFP

(Lobophyllia
hemprichii) 		PF01353
(GFP) 		5 GLN A  38
LEU A 210
ASP A  26
ASN A 105
ARG A  13
 IEY  A  64 ( 3.6A)
IEY  A  64 ( 3.7A)
None
IEY  A  64 ( 4.3A)
None
 1.36A 5uh6C-2btjA:
1.3		 5uh6C-2btjA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1x 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE

(Deinococcus
radiodurans) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
PF13292
(DXP_synthase_N) 		5 LEU A 460
ASP A 561
ARG A 477
ILE A 421
HIS A 604
 None
 1.27A 5uh6C-2o1xA:
0.4		 5uh6C-2o1xA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p18 GLYOXALASE II

(Leishmania
infantum) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		5 ASP A 164
HIS A 143
ASN A  85
ILE A 111
HIS A 210
 ZN  A 301 (-2.5A)
None
None
None
ZN  A 301 ( 3.3A)
 1.49A 5uh6C-2p18A:
0.3		 5uh6C-2p18A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppw CONSERVED DOMAIN
PROTEIN

(Streptococcus
pneumoniae) 		PF02502
(LacAB_rpiB)
PF12408
(DUF3666) 		5 GLN A  46
LEU A  47
GLN A  51
ASP A 177
SER A 186
 None
 1.49A 5uh6C-2ppwA:
0.1		 5uh6C-2ppwA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9y ISWI ONE COMPLEX
PROTEIN 3

(Saccharomyces
cerevisiae) 		PF15612
(WHIM1) 		5 LEU B 185
ASP B 213
ARG B 388
ASN B 255
ILE B 380
 None
 1.41A 5uh6C-2y9yB:
undetectable		 5uh6C-2y9yB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG

(Mycobacterium
tuberculosis) 		PF01474
(DAHP_synth_2) 		5 GLN A  70
LEU A  67
GLN A  68
ASP A 324
ILE A 362
 None
 1.39A 5uh6C-2ypqA:
undetectable		 5uh6C-2ypqA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zds PUTATIVE DNA-BINDING
PROTEIN

(Streptomyces
coelicolor) 		PF01261
(AP_endonuc_2)
PF07582
(AP_endonuc_2_N) 		5 ASP A 125
SER A  70
ASN A 207
ILE A 128
ARG A 174
 None
 1.40A 5uh6C-2zdsA:
undetectable		 5uh6C-2zdsA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 GLN B 412
ASP B 415
HIS B 425
ARG B 428
ASN B 463
 None
 0.93A 5uh6C-3hkzB:
21.8		 5uh6C-3hkzB:
29.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmq DECAHEME CYTOCHROME
C MTRF

(Shewanella
oneidensis) 		no annotation 5 GLN A 494
LEU A 497
GLN A 496
ASN A 470
HIS A 524
 None
None
HEC  A 677 (-3.7A)
None
HEC  A 677 (-3.3A)
 1.27A 5uh6C-3pmqA:
2.0		 5uh6C-3pmqA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ziu LEUCYL-TRNA
SYNTHETASE

(Mycoplasma
mobile) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		5 GLN A 115
ASP A  64
ARG A 434
ARG A  68
HIS A  79
 None
 1.26A 5uh6C-3ziuA:
undetectable		 5uh6C-3ziuA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3s 6-PHOSPHOFRUCTOKINAS
E

(Bacillus
subtilis) 		PF00365
(PFK) 		5 GLN A 312
LEU A 313
ASP A 175
ILE A 189
HIS A 304
 None
 1.25A 5uh6C-4a3sA:
undetectable		 5uh6C-4a3sA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efc ADENYLOSUCCINATE
LYASE

(Trypanosoma
brucei) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		5 GLN A 257
LEU A 254
ILE A 146
ARG A  50
HIS A 133
 None
 1.40A 5uh6C-4efcA:
undetectable		 5uh6C-4efcA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 322
ASP A 386
HIS A 384
ILE A 392
ARG A 388
 None
 1.31A 5uh6C-4lggA:
undetectable		 5uh6C-4lggA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 GLN B 425
ASP B 428
HIS B 438
ARG B 441
ASN B 476
 None
 0.98A 5uh6C-4qiwB:
28.2		 5uh6C-4qiwB:
28.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8f PUTATIVE
UNCHARACTERIZED
PROTEIN GBS1892

(Streptococcus
agalactiae) 		PF02502
(LacAB_rpiB)
PF12408
(DUF3666) 		5 GLN A  46
LEU A  47
GLN A  51
ASP A 177
SER A 186
 None
 1.37A 5uh6C-4u8fA:
undetectable		 5uh6C-4u8fA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zcf RESTRICTION
ENDONUCLEASE
ECOP15I, RESTRICTION
SUBUNIT

(Escherichia
coli) 		PF04851
(ResIII) 		5 LEU C 101
ASP C 139
SER C 104
ILE C 782
HIS C 135
 None
 1.43A 5uh6C-4zcfC:
undetectable		 5uh6C-4zcfC:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zu4 WXCM-LIKE PROTEIN

(Shewanella
denitrificans) 		PF05523
(FdtA) 		5 GLN A 228
LEU A 261
ASP A 198
HIS A 178
ILE A 231
 4TG  A 401 (-3.2A)
None
None
None
None
 1.22A 5uh6C-4zu4A:
undetectable		 5uh6C-4zu4A:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B

(Mus musculus) 		PF00149
(Metallophos) 		5 LEU A 118
ASP A  28
SER A  74
ILE A 322
HIS A 236
 None
ZN  A 502 (-3.0A)
None
None
ZN  A 501 (-3.3A)
 1.34A 5uh6C-5karA:
0.0		 5uh6C-5karA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oon UNDECAPRENYL-DIPHOSP
HATASE

(Escherichia
coli) 		no annotation 5 LEU A 246
SER A 193
ILE A 179
ARG A 261
HIS A  30
 None
None
None
None
OLC  A 304 (-4.5A)
 1.45A 5uh6C-5oonA:
undetectable		 5uh6C-5oonA:
5.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		8 ASP C 432
HIS C 442
ARG C 445
SER C 447
ARG C 456
ASN C 484
ILE C 488
HIS C 671
 None
 1.08A 5uh6C-5tw1C:
50.5		 5uh6C-5tw1C:
91.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		10 GLN C 426
LEU C 427
GLN C 429
ASP C 432
HIS C 442
ARG C 445
SER C 447
ASN C 484
ILE C 488
ARG C 604
 None
 1.24A 5uh6C-5tw1C:
50.5		 5uh6C-5tw1C:
91.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		10 GLN C 426
LEU C 427
GLN C 429
ASP C 432
HIS C 442
ARG C 445
SER C 447
ASN C 484
ILE C 488
HIS C 671
 None
 0.68A 5uh6C-5tw1C:
50.5		 5uh6C-5tw1C:
91.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj6 GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF11721
(Malectin)
PF16355
(DUF4982) 		5 GLN A  36
LEU A 179
ASP A 195
ARG A 106
HIS A 299
 None
 1.49A 5uh6C-5uj6A:
undetectable		 5uh6C-5uj6A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wjc KINETOCHORE PROTEIN
MIS16

(Schizosaccharomyces
pombe) 		no annotation 5 LEU A 407
GLN A 408
HIS A 378
ILE A 385
ARG A 349
 None
 1.50A 5uh6C-5wjcA:
1.7		 5uh6C-5wjcA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfl CATENIN ALPHA-2

(Mus musculus) 		no annotation 5 ASP A 386
HIS A 387
SER A 437
ILE A 438
HIS A 516
 None
 1.45A 5uh6C-5xflA:
undetectable		 5uh6C-5xflA:
5.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k ACTF

(Rhodothermus
marinus) 		no annotation 5 LEU F 179
GLN F 195
HIS F  88
ARG F 196
ARG F  91
 None
 1.50A 5uh6C-6f0kF:
undetectable		 5uh6C-6f0kF:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvv GLUTAMATE--CYSTEINE
LIGASE

(Saccharomyces
cerevisiae) 		PF03074
(GCS) 		4 ARG A 234
PHE A 237
LEU A 246
PRO A 336
 None
 1.40A 5uh6C-3lvvA:
0.0		 5uh6C-3lvvA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iop C-TYPE LECTIN DOMAIN
FAMILY 2 MEMBER A
KILLER CELL
LECTIN-LIKE RECEPTOR
SUBFAMILY F MEMBER 2

(Homo sapiens) 		PF00059
(Lectin_C) 		4 ARG A 158
PHE A 160
LEU B 147
PRO B 158
 None
NAG  A 204 (-4.2A)
None
None
 1.47A 5uh6C-4iopA:
0.0		 5uh6C-4iopA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvc ABC TRANSPORTER
ATP-BINDING PROTEIN

(Geobacillus
kaustophilus) 		PF00005
(ABC_tran) 		4 ARG A 176
PHE A 149
LEU A 128
PRO A 132
 None
 1.42A 5uh6C-4rvcA:
0.0		 5uh6C-4rvcA:
13.06