SIMILAR PATTERNS OF AMINO ACIDS FOR 5UC3_B_486B801_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		4 ASN A 310
MET A 331
MET A 328
TYR A 243
 None
 1.48A 5uc3B-3g05A:
0.0		 5uc3B-3g05A:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igg CATENIN ALPHA-1

(Homo sapiens) 		PF01044
(Vinculin) 		4 ASN A 791
MET A 723
MET A 726
TYR A 786
 None
 0.94A 5uc3B-4iggA:
0.5		 5uc3B-4iggA:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k1o CATENIN ALPHA-2

(Mus musculus) 		PF01044
(Vinculin) 		4 ASN A 790
MET A 722
MET A 725
TYR A 785
 None
 1.10A 5uc3B-4k1oA:
0.0		 5uc3B-4k1oA:
15.77