SIMILAR PATTERNS OF AMINO ACIDS FOR 5UC3_B_486B801_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjx 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Pseudomonas
fluorescens) 		PF00903
(Glyoxalase)
PF14696
(Glyoxalase_5) 		5 LEU A 255
GLY A  34
GLN A  51
PHE A 323
LEU A 315
 None
 1.44A 5uc3B-1cjxA:
undetectable		 5uc3B-1cjxA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4y ANTI-SIGMA F FACTOR
ANTAGONIST

(Lysinibacillus
sphaericus) 		PF01740
(STAS) 		5 MET A  99
LEU A  79
VAL A  14
MET A  55
LEU A  52
 None
 1.26A 5uc3B-1h4yA:
undetectable		 5uc3B-1h4yA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE

(Rhodotorula
toruloides) 		PF00221
(Lyase_aromatic) 		5 LEU A 372
GLN A  44
VAL A  45
GLN A 439
LEU A 296
 None
 1.19A 5uc3B-1t6pA:
undetectable		 5uc3B-1t6pA:
7.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 GLY A 708
GLN A 711
ARG A 752
PHE A 764
LEU A 873
 BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 (-3.8A)
BHM  A   1 (-4.4A)
BHM  A   1 (-4.4A)
 0.69A 5uc3B-2ax9A:
28.5		 5uc3B-2ax9A:
51.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 704
GLY A 708
GLN A 711
ARG A 752
PHE A 764
MET A 787
 BHM  A   1 (-4.0A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 (-3.8A)
BHM  A   1 (-4.4A)
BHM  A   1 (-3.6A)
 0.70A 5uc3B-2ax9A:
28.5		 5uc3B-2ax9A:
51.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0h MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Mytilus edulis) 		PF00150
(Cellulase) 		5 GLY A 307
GLN A 275
VAL A 276
PHE A 122
LEU A  26
 None
 1.24A 5uc3B-2c0hA:
undetectable		 5uc3B-2c0hA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebz REGULATOR OF
G-PROTEIN SIGNALING
12

(Homo sapiens) 		PF00615
(RGS) 		5 LEU A  23
GLY A  28
PHE A  19
MET A 117
LEU A  36
 None
 1.27A 5uc3B-2ebzA:
undetectable		 5uc3B-2ebzA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF13416
(SBP_bac_8) 		5 MET A 129
LEU A 132
ARG A 148
PHE A 150
LEU A 198
 None
 1.34A 5uc3B-2ghbA:
undetectable		 5uc3B-2ghbA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 MET A 343
LEU A 346
ARG A 394
PHE A 404
LEU A 384
 EST  A 596 (-4.8A)
EST  A 596 (-4.4A)
EST  A 596 (-4.0A)
None
None
 1.11A 5uc3B-2ocfA:
25.4		 5uc3B-2ocfA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 MET A 343
LEU A 346
TRP A 383
ARG A 394
PHE A 404
 EST  A 596 (-4.8A)
EST  A 596 (-4.4A)
None
EST  A 596 (-4.0A)
None
 0.81A 5uc3B-2ocfA:
25.4		 5uc3B-2ocfA:
15.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		5 GLN A  39
VAL A  43
PHE A  92
MET A 115
LEU A 201
 1CA  A 247 (-3.1A)
None
None
1CA  A 247 ( 3.7A)
1CA  A 247 ( 4.2A)
 1.29A 5uc3B-2q3yA:
31.5		 5uc3B-2q3yA:
58.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		8 LEU A  32
GLN A  39
TRP A  69
ARG A  80
PHE A  92
MET A 115
LEU A 201
CYH A 205
 1CA  A 247 (-4.0A)
1CA  A 247 (-3.1A)
None
1CA  A 247 (-3.8A)
None
1CA  A 247 ( 3.7A)
1CA  A 247 ( 4.2A)
1CA  A 247 (-4.0A)
 0.54A 5uc3B-2q3yA:
31.5		 5uc3B-2q3yA:
58.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vtx NPM-A PROTEIN

(Xenopus laevis) 		PF03066
(Nucleoplasmin) 		5 MET A  91
LEU A  47
GLY A 115
LEU A 111
CYH A  51
 None
 1.25A 5uc3B-2vtxA:
undetectable		 5uc3B-2vtxA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wl8 PEROXISOMAL
BIOGENESIS FACTOR 19

(Homo sapiens) 		PF04614
(Pex19) 		5 LEU A 268
GLY A 270
GLN A 221
MET A 225
LEU A 258
 None
 1.26A 5uc3B-2wl8A:
undetectable		 5uc3B-2wl8A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT

(Thermus
thermophilus) 		PF00344
(SecY) 		5 MET Y  78
GLY Y 191
VAL Y 193
ARG Y  69
GLN Y 282
 None
 1.35A 5uc3B-2zqpY:
undetectable		 5uc3B-2zqpY:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3o PUTATIVE
TRANSCRIPTIONAL
REGULATOR, ICIR
FAMILY

(Acinetobacter
sp. ADP1) 		no annotation 5 LEU A 159
GLY A 161
VAL A  10
MET A  64
LEU A 126
 None
 1.40A 5uc3B-3d3oA:
undetectable		 5uc3B-3d3oA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8b FIDGETIN-LIKE
PROTEIN 1

(Homo sapiens) 		PF00004
(AAA)
PF09336
(Vps4_C) 		5 MET A 608
LEU A 611
ARG A 649
PHE A 648
LEU A 588
 None
 1.43A 5uc3B-3d8bA:
undetectable		 5uc3B-3d8bA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf9 INTERSECTIN 2

(Homo sapiens) 		PF00621
(RhoGEF) 		5 LEU A1319
GLY A1283
PHE A1226
MET A1211
LEU A1301
 UNX  A   3 (-4.5A)
UNX  A   3 (-3.4A)
None
None
None
 1.29A 5uc3B-3gf9A:
undetectable		 5uc3B-3gf9A:
17.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 GLY A 722
GLN A 725
ARG A 766
PHE A 778
MET A 801
LEU A 887
 WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
None
WOW  A   1 (-4.2A)
WOW  A   1 (-4.0A)
 0.68A 5uc3B-3kbaA:
30.9		 5uc3B-3kbaA:
53.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 718
GLY A 722
ARG A 766
PHE A 778
MET A 801
LEU A 887
CYH A 891
 WOW  A   1 (-4.2A)
WOW  A   1 ( 4.3A)
WOW  A   1 (-3.8A)
None
WOW  A   1 (-4.2A)
WOW  A   1 (-4.0A)
WOW  A   1 (-3.5A)
 0.52A 5uc3B-3kbaA:
30.9		 5uc3B-3kbaA:
53.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2

(Homo sapiens) 		PF01401
(Peptidase_M2) 		5 GLY A 377
GLN A 380
PHE A 314
GLN A 526
LEU A 529
 None
 1.49A 5uc3B-3kbhA:
undetectable		 5uc3B-3kbhA:
9.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		9 LEU A  32
GLY A  36
GLN A  39
TRP A  69
ARG A  80
PHE A  92
MET A 115
LEU A 201
CYH A 205
 1CA  A 249 (-3.9A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
None
1CA  A 249 (-3.5A)
None
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
1CA  A 249 (-4.0A)
 0.72A 5uc3B-3ry9A:
31.0		 5uc3B-3ry9A:
69.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t95 AUTOINDUCER
2-BINDING PROTEIN
LSRB

(Yersinia pestis) 		PF13407
(Peripla_BP_4) 		5 MET A 138
LEU A 135
GLN A 309
VAL A 308
LEU A 323
 None
 1.29A 5uc3B-3t95A:
undetectable		 5uc3B-3t95A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up3 ACEDAF-12

(Ancylostoma
ceylanicum) 		PF00104
(Hormone_recep) 		5 LEU A 664
GLY A 662
PHE A 665
MET A 492
LEU A 529
 XCA  A 100 (-4.8A)
None
None
None
XCA  A 100 (-4.3A)
 1.04A 5uc3B-3up3A:
16.9		 5uc3B-3up3A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmr PROLINE
IMINOPEPTIDASE

(Streptomyces
halstedii) 		PF00561
(Abhydrolase_1) 		5 LEU A 245
VAL A 187
PHE A 287
MET A  50
LEU A  47
 None
 1.44A 5uc3B-3wmrA:
undetectable		 5uc3B-3wmrA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ip4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Ruegeria sp.
TM1040) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 MET A 300
GLY A 351
VAL A 382
TRP A 192
GLN A 249
 None
GOL  A 501 (-3.5A)
None
None
None
 1.44A 5uc3B-4ip4A:
undetectable		 5uc3B-4ip4A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbf HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A 272
GLY A 270
VAL A 297
GLN A 266
LEU A 292
 None
 1.43A 5uc3B-4kbfA:
undetectable		 5uc3B-4kbfA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lle PROBABLE
TWO-COMPONENT SENSOR

(Pseudomonas
aeruginosa) 		PF16767
(KinB_sensor) 		5 LEU A  60
GLY A  64
VAL A  68
GLN A 150
LEU A 146
 None
GOL  A 201 (-3.7A)
None
None
None
 0.91A 5uc3B-4lleA:
undetectable		 5uc3B-4lleA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mad BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF01301
(Glyco_hydro_35) 		5 GLY A 406
GLN A 407
VAL A 408
PHE A 381
GLN A 377
 None
 1.48A 5uc3B-4madA:
undetectable		 5uc3B-4madA:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nen INTEGRIN ALPHA-X
INTEGRIN BETA-2

(Homo sapiens) 		PF00092
(VWA)
PF00362
(Integrin_beta)
PF01839
(FG-GAP)
PF07965
(Integrin_B_tail)
PF08441
(Integrin_alpha2)
PF17205
(PSI_integrin) 		5 MET B 218
LEU B 215
GLY B 213
ARG A 407
PHE B 245
 None
 1.49A 5uc3B-4nenB:
undetectable		 5uc3B-4nenB:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o0m CIRCADIAN CLOCK
PROTEIN KINASE KAIC

(Thermosynechococcus
elongatus) 		PF06745
(ATPase) 		5 GLY A 120
GLN A 154
VAL A 118
PHE A 152
LEU A 127
 None
 0.88A 5uc3B-4o0mA:
undetectable		 5uc3B-4o0mA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oku MICRONEMAL PROTEIN
MIC2

(Toxoplasma
gondii) 		PF00090
(TSP_1)
PF00092
(VWA) 		5 LEU A 214
GLY A 185
VAL A 183
PHE A  98
LEU A 260
 None
 1.41A 5uc3B-4okuA:
undetectable		 5uc3B-4okuA:
13.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 LEU A 563
GLY A 567
GLN A 570
VAL A 571
TRP A 600
ARG A 611
PHE A 623
MET A 646
LEU A 732
CYH A 736
 MOF  A 801 (-3.9A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
None
None
MOF  A 801 (-4.2A)
MOF  A 801 (-4.7A)
MOF  A 801 (-4.4A)
MOF  A 801 ( 4.2A)
MOF  A 801 (-3.7A)
 0.63A 5uc3B-4p6wA:
33.4		 5uc3B-4p6wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 MET A 560
VAL A 571
TRP A 600
MET A 646
LEU A 732
CYH A 736
 MOF  A 801 (-3.9A)
None
None
MOF  A 801 (-4.4A)
MOF  A 801 ( 4.2A)
MOF  A 801 (-3.7A)
 0.92A 5uc3B-4p6wA:
33.4		 5uc3B-4p6wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 TRP A 600
GLN A 642
MET A 646
LEU A 732
CYH A 736
 None
None
MOF  A 801 (-4.4A)
MOF  A 801 ( 4.2A)
MOF  A 801 (-3.7A)
 0.99A 5uc3B-4p6wA:
33.4		 5uc3B-4p6wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 769
GLN A 776
TRP A 806
ARG A 817
PHE A 829
MET A 852
LEU A 938
CYH A 942
 CV7  A1987 (-4.1A)
CV7  A1987 (-3.0A)
None
CV7  A1987 (-3.7A)
CV7  A1987 (-4.9A)
CV7  A1987 ( 3.7A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-4.0A)
 0.58A 5uc3B-4udbA:
29.3		 5uc3B-4udbA:
48.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmh HEME OXYGENASE 2

(Homo sapiens) 		PF01126
(Heme_oxygenase) 		5 MET A 158
LEU A 161
GLY A 164
GLN A 165
VAL A 166
 None
 1.17A 5uc3B-4wmhA:
undetectable		 5uc3B-4wmhA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfw ALPHA-CARBONIC
ANHYDRASE

(Helicobacter
pylori) 		PF00194
(Carb_anhydrase) 		5 LEU A 126
GLY A 145
VAL A 204
PHE A 111
GLN A 214
 None
 1.35A 5uc3B-4xfwA:
undetectable		 5uc3B-4xfwA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE

(Bacillus
licheniformis) 		PF01019
(G_glu_transpept) 		5 LEU A 427
GLN A 218
VAL A 217
PHE A 434
LEU A 204
 None
 1.34A 5uc3B-4y23A:
undetectable		 5uc3B-4y23A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aee ALPHA-GLUCOSIDASE
YIHQ

(Escherichia
coli) 		PF01055
(Glyco_hydro_31) 		5 LEU A 493
GLY A 131
PHE A 182
GLN A 246
LEU A 243
 None
 1.27A 5uc3B-5aeeA:
undetectable		 5uc3B-5aeeA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Pseudomonas
aeruginosa) 		PF00202
(Aminotran_3) 		5 GLY A 269
VAL A  71
PHE A 243
MET A 102
LEU A  98
 None
 1.49A 5uc3B-5i92A:
undetectable		 5uc3B-5i92A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kl0 PHOSPHOGLUCOMUTASE

(Xanthomonas
citri) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 LEU A 280
GLY A 282
GLN A 310
VAL A 311
LEU A 364
 None
 1.39A 5uc3B-5kl0A:
undetectable		 5uc3B-5kl0A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mll DNA PROCESSING CHAIN
A (DPRA)

(Helicobacter
pylori) 		no annotation 5 LEU A  99
GLY A  79
GLN A  89
LEU A 104
CYH A 102
 None
None
None
EDO  A 301 (-4.5A)
EDO  A 301 (-3.3A)
 1.05A 5uc3B-5mllA:
undetectable		 5uc3B-5mllA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mll DNA PROCESSING CHAIN
A (DPRA)

(Helicobacter
pylori) 		no annotation 5 LEU A  99
GLY A  80
GLN A  89
LEU A 104
CYH A 102
 None
None
None
EDO  A 301 (-4.5A)
EDO  A 301 (-3.3A)
 1.05A 5uc3B-5mllA:
undetectable		 5uc3B-5mllA:
19.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 GLN A 776
TRP A 806
ARG A 817
MET A 852
LEU A 938
 ECV  A1101 (-2.9A)
None
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
ECV  A1101 ( 4.3A)
 1.25A 5uc3B-5mwpA:
29.7		 5uc3B-5mwpA:
45.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 7 LEU A 769
GLN A 776
TRP A 806
ARG A 817
PHE A 829
LEU A 938
CYH A 942
 ECV  A1101 (-4.7A)
ECV  A1101 (-2.9A)
None
ECV  A1101 (-4.0A)
ECV  A1101 ( 4.9A)
ECV  A1101 ( 4.3A)
ECV  A1101 (-4.0A)
 0.60A 5uc3B-5mwpA:
29.7		 5uc3B-5mwpA:
45.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7s TYPE II SECRETION
SYSTEM PROTEIN L

(Pseudomonas
aeruginosa) 		no annotation 5 LEU B 305
GLY B 381
VAL B 362
ARG B 333
PHE B 329
 None
 1.46A 5uc3B-5n7sB:
undetectable		 5uc3B-5n7sB:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0s GLUCOSYLCERAMIDASE

(Thermoanaerobacterium
xylanolyticum) 		PF04685
(DUF608)
PF12215
(Glyco_hydr_116N)
PF17168
(DUF5127) 		5 GLN A 110
VAL A 106
TRP A  94
PHE A 111
LEU A  75
 None
 1.03A 5uc3B-5o0sA:
undetectable		 5uc3B-5o0sA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE

(Homo sapiens) 		no annotation 5 LEU A 191
GLY A 308
GLN A 363
PHE A 206
LEU A 301
 None
 1.34A 5uc3B-5txfA:
undetectable		 5uc3B-5txfA:
11.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 7 GLY A 563
GLN A 566
VAL A 567
TRP A 596
ARG A 607
PHE A 619
MET A 642
 486  A 801 (-3.7A)
486  A 801 (-2.8A)
None
None
486  A 801 (-3.5A)
486  A 801 (-4.7A)
486  A 801 ( 3.8A)
 0.67A 5uc3B-5uc1A:
28.2		 5uc3B-5uc1A:
96.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 7 LEU A 559
GLY A 563
GLN A 566
VAL A 567
ARG A 607
PHE A 619
GLN A 638
 486  A 801 (-4.7A)
486  A 801 (-3.7A)
486  A 801 (-2.8A)
None
486  A 801 (-3.5A)
486  A 801 (-4.7A)
486  A 801 (-4.6A)
 0.71A 5uc3B-5uc1A:
28.2		 5uc3B-5uc1A:
96.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 7 LEU A 559
GLY A 563
GLN A 566
VAL A 567
ARG A 607
PHE A 619
MET A 642
 486  A 801 (-4.7A)
486  A 801 (-3.7A)
486  A 801 (-2.8A)
None
486  A 801 (-3.5A)
486  A 801 (-4.7A)
486  A 801 ( 3.8A)
 0.54A 5uc3B-5uc1A:
28.2		 5uc3B-5uc1A:
96.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		10 LEU A  32
GLY A  36
GLN A  39
VAL A  40
TRP A  69
ARG A  80
PHE A  92
MET A 115
LEU A 201
CYH A 205
 1TA  A 301 (-3.5A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
None
None
1TA  A 301 (-3.5A)
1TA  A 301 (-4.4A)
1TA  A 301 ( 2.8A)
1TA  A 301 ( 3.8A)
1TA  A 301 (-3.6A)
 0.53A 5uc3B-5ufsA:
33.0		 5uc3B-5ufsA:
75.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 MET A  29
GLY A  36
VAL A  40
TRP A  69
LEU A 201
CYH A 205
 1TA  A 301 ( 2.9A)
1TA  A 301 (-2.9A)
None
None
1TA  A 301 ( 3.8A)
1TA  A 301 (-3.6A)
 0.97A 5uc3B-5ufsA:
33.0		 5uc3B-5ufsA:
75.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 VAL A  40
TRP A  69
ARG A  80
GLN A 111
MET A 115
CYH A 205
 None
None
1TA  A 301 (-3.5A)
None
1TA  A 301 ( 2.8A)
1TA  A 301 (-3.6A)
 1.46A 5uc3B-5ufsA:
33.0		 5uc3B-5ufsA:
75.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dex SUPPRESSOR OF
HYDROXYUREA
SENSITIVITY PROTEIN
2

(Eremothecium
gossypii) 		no annotation 5 LEU B  12
ARG B 125
PHE B 136
MET B 153
LEU B  38
 None
 1.26A 5uc3B-6dexB:
undetectable		 5uc3B-6dexB:
17.07