SIMILAR PATTERNS OF AMINO ACIDS FOR 5UC3_A_486A801_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eu1 DIMETHYL SULFOXIDE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 ASN A 192
GLY A 363
GLN A 168
MET A 181
LEU A 210
 None
 1.33A 5uc3A-1eu1A:
undetectable		 5uc3A-1eu1A:
8.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ASN A 705
GLY A 708
GLN A 711
MET A 745
ARG A 752
PHE A 764
LEU A 873
 BHM  A   1 (-3.6A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 (-3.9A)
BHM  A   1 (-3.8A)
BHM  A   1 (-4.4A)
BHM  A   1 (-4.4A)
 0.75A 5uc3A-2ax9A:
28.6		 5uc3A-2ax9A:
51.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 GLY A 708
GLN A 711
MET A 745
ARG A 752
PHE A 764
MET A 787
 BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 (-3.9A)
BHM  A   1 (-3.8A)
BHM  A   1 (-4.4A)
BHM  A   1 (-3.6A)
 0.72A 5uc3A-2ax9A:
28.6		 5uc3A-2ax9A:
51.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 MET A 343
ARG A 394
PHE A 404
MET A 421
LEU A 384
 EST  A 596 (-4.8A)
EST  A 596 (-4.0A)
None
EST  A 596 (-4.5A)
None
 1.26A 5uc3A-2ocfA:
25.5		 5uc3A-2ocfA:
15.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		9 ASN A  33
GLN A  39
TRP A  69
MET A  73
ARG A  80
PHE A  92
MET A 115
LEU A 201
CYH A 205
 1CA  A 247 (-2.9A)
1CA  A 247 (-3.1A)
None
1CA  A 247 (-3.6A)
1CA  A 247 (-3.8A)
None
1CA  A 247 ( 3.7A)
1CA  A 247 ( 4.2A)
1CA  A 247 (-4.0A)
 0.57A 5uc3A-2q3yA:
31.6		 5uc3A-2q3yA:
58.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1a PUTATIVE
OXIDOREDUCTASE

(Magnetospirillum
magnetotacticum) 		PF01408
(GFO_IDH_MocA) 		5 GLY A 261
GLN A 258
TRP A 263
MET A 183
LEU A 233
 None
None
None
None
PG4  A 315 ( 4.2A)
 1.44A 5uc3A-3c1aA:
undetectable		 5uc3A-3c1aA:
14.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ASN A 719
GLY A 722
GLN A 725
MET A 759
ARG A 766
MET A 801
LEU A 887
 WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-4.0A)
 0.85A 5uc3A-3kbaA:
31.2		 5uc3A-3kbaA:
53.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 ASN A 719
GLY A 722
MET A 759
ARG A 766
PHE A 778
MET A 801
LEU A 887
CYH A 891
 WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 (-3.7A)
WOW  A   1 (-3.8A)
None
WOW  A   1 (-4.2A)
WOW  A   1 (-4.0A)
WOW  A   1 (-3.5A)
 0.70A 5uc3A-3kbaA:
31.2		 5uc3A-3kbaA:
53.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		10 ASN A  33
GLY A  36
GLN A  39
TRP A  69
MET A  73
ARG A  80
PHE A  92
MET A 115
LEU A 201
CYH A 205
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
None
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
None
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
1CA  A 249 (-4.0A)
 0.75A 5uc3A-3ry9A:
31.3		 5uc3A-3ry9A:
69.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 ASN A 564
GLY A 567
GLN A 570
MET A 604
ARG A 611
PHE A 623
MET A 639
MET A 646
LEU A 732
 MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
None
MOF  A 801 (-4.2A)
MOF  A 801 (-4.7A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.4A)
MOF  A 801 ( 4.2A)
 0.69A 5uc3A-4p6wA:
34.1		 5uc3A-4p6wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 ASN A 564
GLY A 567
GLN A 570
TRP A 600
ARG A 611
PHE A 623
MET A 639
MET A 646
LEU A 732
CYH A 736
 MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
None
MOF  A 801 (-4.2A)
MOF  A 801 (-4.7A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.4A)
MOF  A 801 ( 4.2A)
MOF  A 801 (-3.7A)
 0.70A 5uc3A-4p6wA:
34.1		 5uc3A-4p6wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 MET A 560
ASN A 564
TRP A 600
MET A 646
LEU A 732
CYH A 736
 MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
None
MOF  A 801 (-4.4A)
MOF  A 801 ( 4.2A)
MOF  A 801 (-3.7A)
 1.00A 5uc3A-4p6wA:
34.1		 5uc3A-4p6wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 ASN A 770
GLN A 776
TRP A 806
ARG A 817
PHE A 829
MET A 852
LEU A 938
CYH A 942
 CV7  A1987 (-3.1A)
CV7  A1987 (-3.0A)
None
CV7  A1987 (-3.7A)
CV7  A1987 (-4.9A)
CV7  A1987 ( 3.7A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-4.0A)
 0.72A 5uc3A-4udbA:
29.7		 5uc3A-4udbA:
48.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 7 ASN A 770
GLN A 776
TRP A 806
ARG A 817
PHE A 829
LEU A 938
CYH A 942
 ECV  A1101 (-3.1A)
ECV  A1101 (-2.9A)
None
ECV  A1101 (-4.0A)
ECV  A1101 ( 4.9A)
ECV  A1101 ( 4.3A)
ECV  A1101 (-4.0A)
 0.70A 5uc3A-5mwpA:
29.8		 5uc3A-5mwpA:
45.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 GLN A 776
TRP A 806
ARG A 817
MET A 852
LEU A 938
 ECV  A1101 (-2.9A)
None
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
ECV  A1101 ( 4.3A)
 1.27A 5uc3A-5mwpA:
29.8		 5uc3A-5mwpA:
45.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 9 ASN A 560
GLY A 563
GLN A 566
TRP A 596
MET A 600
ARG A 607
PHE A 619
MET A 635
MET A 642
 486  A 801 (-4.2A)
486  A 801 (-3.7A)
486  A 801 (-2.8A)
None
None
486  A 801 (-3.5A)
486  A 801 (-4.7A)
486  A 801 ( 4.7A)
486  A 801 ( 3.8A)
 0.67A 5uc3A-5uc1A:
28.2		 5uc3A-5uc1A:
96.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		9 ASN A  33
GLY A  36
GLN A  39
MET A  73
ARG A  80
PHE A  92
MET A 108
MET A 115
LEU A 201
 1TA  A 301 (-3.0A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.2A)
1TA  A 301 (-3.5A)
1TA  A 301 (-4.4A)
1TA  A 301 ( 3.0A)
1TA  A 301 ( 2.8A)
1TA  A 301 ( 3.8A)
 0.62A 5uc3A-5ufsA:
33.2		 5uc3A-5ufsA:
75.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		10 ASN A  33
GLY A  36
GLN A  39
TRP A  69
ARG A  80
PHE A  92
MET A 108
MET A 115
LEU A 201
CYH A 205
 1TA  A 301 (-3.0A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
None
1TA  A 301 (-3.5A)
1TA  A 301 (-4.4A)
1TA  A 301 ( 3.0A)
1TA  A 301 ( 2.8A)
1TA  A 301 ( 3.8A)
1TA  A 301 (-3.6A)
 0.72A 5uc3A-5ufsA:
33.2		 5uc3A-5ufsA:
75.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		7 MET A  29
ASN A  33
GLY A  36
TRP A  69
MET A 108
LEU A 201
CYH A 205
 1TA  A 301 ( 2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 (-2.9A)
None
1TA  A 301 ( 3.0A)
1TA  A 301 ( 3.8A)
1TA  A 301 (-3.6A)
 1.11A 5uc3A-5ufsA:
33.2		 5uc3A-5ufsA:
75.64