SIMILAR PATTERNS OF AMINO ACIDS FOR 5UC3_A_486A801

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eu1 DIMETHYL SULFOXIDE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 ASN A 192
GLY A 363
GLN A 168
MET A 181
LEU A 210
 None
 1.33A 5uc3A-1eu1A:
undetectable		 5uc3A-1eu1A:
8.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ASN A 705
GLY A 708
GLN A 711
MET A 745
ARG A 752
PHE A 764
LEU A 873
 BHM  A   1 (-3.6A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 (-3.9A)
BHM  A   1 (-3.8A)
BHM  A   1 (-4.4A)
BHM  A   1 (-4.4A)
 0.75A 5uc3A-2ax9A:
28.6		 5uc3A-2ax9A:
51.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 GLY A 708
GLN A 711
MET A 745
ARG A 752
PHE A 764
MET A 787
 BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 (-3.9A)
BHM  A   1 (-3.8A)
BHM  A   1 (-4.4A)
BHM  A   1 (-3.6A)
 0.72A 5uc3A-2ax9A:
28.6		 5uc3A-2ax9A:
51.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 MET A 343
ARG A 394
PHE A 404
MET A 421
LEU A 384
 EST  A 596 (-4.8A)
EST  A 596 (-4.0A)
None
EST  A 596 (-4.5A)
None
 1.26A 5uc3A-2ocfA:
25.5		 5uc3A-2ocfA:
15.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		9 ASN A  33
GLN A  39
TRP A  69
MET A  73
ARG A  80
PHE A  92
MET A 115
LEU A 201
CYH A 205
 1CA  A 247 (-2.9A)
1CA  A 247 (-3.1A)
None
1CA  A 247 (-3.6A)
1CA  A 247 (-3.8A)
None
1CA  A 247 ( 3.7A)
1CA  A 247 ( 4.2A)
1CA  A 247 (-4.0A)
 0.57A 5uc3A-2q3yA:
31.6		 5uc3A-2q3yA:
58.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1a PUTATIVE
OXIDOREDUCTASE

(Magnetospirillum
magnetotacticum) 		PF01408
(GFO_IDH_MocA) 		5 GLY A 261
GLN A 258
TRP A 263
MET A 183
LEU A 233
 None
None
None
None
PG4  A 315 ( 4.2A)
 1.44A 5uc3A-3c1aA:
undetectable		 5uc3A-3c1aA:
14.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ASN A 719
GLY A 722
GLN A 725
MET A 759
ARG A 766
MET A 801
LEU A 887
 WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-4.0A)
 0.85A 5uc3A-3kbaA:
31.2		 5uc3A-3kbaA:
53.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 ASN A 719
GLY A 722
MET A 759
ARG A 766
PHE A 778
MET A 801
LEU A 887
CYH A 891
 WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 (-3.7A)
WOW  A   1 (-3.8A)
None
WOW  A   1 (-4.2A)
WOW  A   1 (-4.0A)
WOW  A   1 (-3.5A)
 0.70A 5uc3A-3kbaA:
31.2		 5uc3A-3kbaA:
53.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		10 ASN A  33
GLY A  36
GLN A  39
TRP A  69
MET A  73
ARG A  80
PHE A  92
MET A 115
LEU A 201
CYH A 205
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
None
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
None
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
1CA  A 249 (-4.0A)
 0.75A 5uc3A-3ry9A:
31.3		 5uc3A-3ry9A:
69.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 ASN A 564
GLY A 567
GLN A 570
MET A 604
ARG A 611
PHE A 623
MET A 639
MET A 646
LEU A 732
 MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
None
MOF  A 801 (-4.2A)
MOF  A 801 (-4.7A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.4A)
MOF  A 801 ( 4.2A)
 0.69A 5uc3A-4p6wA:
34.1		 5uc3A-4p6wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 ASN A 564
GLY A 567
GLN A 570
TRP A 600
ARG A 611
PHE A 623
MET A 639
MET A 646
LEU A 732
CYH A 736
 MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
None
MOF  A 801 (-4.2A)
MOF  A 801 (-4.7A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.4A)
MOF  A 801 ( 4.2A)
MOF  A 801 (-3.7A)
 0.70A 5uc3A-4p6wA:
34.1		 5uc3A-4p6wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 MET A 560
ASN A 564
TRP A 600
MET A 646
LEU A 732
CYH A 736
 MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
None
MOF  A 801 (-4.4A)
MOF  A 801 ( 4.2A)
MOF  A 801 (-3.7A)
 1.00A 5uc3A-4p6wA:
34.1		 5uc3A-4p6wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 ASN A 770
GLN A 776
TRP A 806
ARG A 817
PHE A 829
MET A 852
LEU A 938
CYH A 942
 CV7  A1987 (-3.1A)
CV7  A1987 (-3.0A)
None
CV7  A1987 (-3.7A)
CV7  A1987 (-4.9A)
CV7  A1987 ( 3.7A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-4.0A)
 0.72A 5uc3A-4udbA:
29.7		 5uc3A-4udbA:
48.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 7 ASN A 770
GLN A 776
TRP A 806
ARG A 817
PHE A 829
LEU A 938
CYH A 942
 ECV  A1101 (-3.1A)
ECV  A1101 (-2.9A)
None
ECV  A1101 (-4.0A)
ECV  A1101 ( 4.9A)
ECV  A1101 ( 4.3A)
ECV  A1101 (-4.0A)
 0.70A 5uc3A-5mwpA:
29.8		 5uc3A-5mwpA:
45.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 GLN A 776
TRP A 806
ARG A 817
MET A 852
LEU A 938
 ECV  A1101 (-2.9A)
None
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
ECV  A1101 ( 4.3A)
 1.27A 5uc3A-5mwpA:
29.8		 5uc3A-5mwpA:
45.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 9 ASN A 560
GLY A 563
GLN A 566
TRP A 596
MET A 600
ARG A 607
PHE A 619
MET A 635
MET A 642
 486  A 801 (-4.2A)
486  A 801 (-3.7A)
486  A 801 (-2.8A)
None
None
486  A 801 (-3.5A)
486  A 801 (-4.7A)
486  A 801 ( 4.7A)
486  A 801 ( 3.8A)
 0.67A 5uc3A-5uc1A:
28.2		 5uc3A-5uc1A:
96.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		9 ASN A  33
GLY A  36
GLN A  39
MET A  73
ARG A  80
PHE A  92
MET A 108
MET A 115
LEU A 201
 1TA  A 301 (-3.0A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.2A)
1TA  A 301 (-3.5A)
1TA  A 301 (-4.4A)
1TA  A 301 ( 3.0A)
1TA  A 301 ( 2.8A)
1TA  A 301 ( 3.8A)
 0.62A 5uc3A-5ufsA:
33.2		 5uc3A-5ufsA:
75.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		10 ASN A  33
GLY A  36
GLN A  39
TRP A  69
ARG A  80
PHE A  92
MET A 108
MET A 115
LEU A 201
CYH A 205
 1TA  A 301 (-3.0A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
None
1TA  A 301 (-3.5A)
1TA  A 301 (-4.4A)
1TA  A 301 ( 3.0A)
1TA  A 301 ( 2.8A)
1TA  A 301 ( 3.8A)
1TA  A 301 (-3.6A)
 0.72A 5uc3A-5ufsA:
33.2		 5uc3A-5ufsA:
75.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		7 MET A  29
ASN A  33
GLY A  36
TRP A  69
MET A 108
LEU A 201
CYH A 205
 1TA  A 301 ( 2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 (-2.9A)
None
1TA  A 301 ( 3.0A)
1TA  A 301 ( 3.8A)
1TA  A 301 (-3.6A)
 1.11A 5uc3A-5ufsA:
33.2		 5uc3A-5ufsA:
75.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkd GROEL

(Escherichia
coli) 		PF00118
(Cpn60_TCP1) 		4 LEU A 222
LEU A 221
MET A 307
GLN A 290
 None
 1.35A 5uc3A-1dkdA:
0.0		 5uc3A-1dkdA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dpp DIPEPTIDE BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		4 LEU A 120
LEU A 123
GLN A  97
TYR A 112
 None
 1.37A 5uc3A-1dppA:
0.0		 5uc3A-1dppA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hq8 NKG2-D

(Mus musculus) 		PF00059
(Lectin_C) 		4 LEU A 195
LEU A 197
GLN A 159
TYR A 154
 None
 1.37A 5uc3A-1hq8A:
0.0		 5uc3A-1hq8A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i4g ENTEROTOXIN TYPE A

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		4 LEU A  23
LEU A  18
GLN A 164
TYR A  31
 None
 1.44A 5uc3A-1i4gA:
undetectable		 5uc3A-1i4gA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8q HYALURONATE LYASE

(Streptococcus
agalactiae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 LEU A 958
LEU A 956
MET A 951
TYR A 966
 None
 1.29A 5uc3A-1i8qA:
0.0		 5uc3A-1i8qA:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqg CARBOXYPEPTIDASE A

(Helicoverpa
armigera) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		4 LEU A  76
LEU A  67
MET A  64
TYR A  81
 None
 1.43A 5uc3A-1jqgA:
0.0		 5uc3A-1jqgA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jya YOPE REGULATOR

(Yersinia
pseudotuberculosis) 		PF05932
(CesT) 		4 LEU A  98
LEU A  95
MET A  48
TYR A 104
 None
 1.37A 5uc3A-1jyaA:
0.0		 5uc3A-1jyaA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knr L-ASPARTATE OXIDASE

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 LEU A 499
LEU A 238
MET A 447
GLN A 471
 None
 0.91A 5uc3A-1knrA:
0.0		 5uc3A-1knrA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1la1 GROEL

(Escherichia
coli) 		PF00118
(Cpn60_TCP1) 		4 LEU A 222
LEU A 221
MET A 307
GLN A 290
 None
 1.29A 5uc3A-1la1A:
undetectable		 5uc3A-1la1A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o94 ELECTRON TRANSFER
FLAVOPROTEIN
BETA-SUBUNIT
TRIMETHYLAMINE
DEHYDROGENASE

(Methylophilus
methylotrophus) 		PF00724
(Oxidored_FMN)
PF01012
(ETF)
PF07992
(Pyr_redox_2) 		4 LEU C 194
MET A 470
GLN A 462
TYR C 191
 None
 0.68A 5uc3A-1o94C:
undetectable		 5uc3A-1o94C:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qy9 HYPOTHETICAL PROTEIN
YDDE

(Escherichia
coli) 		PF02567
(PhzC-PhzF) 		4 LEU A 149
LEU A 152
MET A 232
GLN A 200
 None
 1.16A 5uc3A-1qy9A:
undetectable		 5uc3A-1qy9A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwy CARBOXYPEPTIDASE M

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		4 LEU A 263
LEU A 265
MET A  65
GLN A 249
 None
 1.22A 5uc3A-1uwyA:
undetectable		 5uc3A-1uwyA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x77 CONSERVED
HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF03358
(FMN_red) 		4 LEU A  26
LEU A  41
MET A  37
GLN A 174
 None
 1.43A 5uc3A-1x77A:
undetectable		 5uc3A-1x77A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt3 RIBONUCLEASE D

(Escherichia
coli) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		4 LEU A 159
LEU A 160
MET A   1
TYR A 151
 None
None
None
ZN  A1001 (-3.9A)
 1.45A 5uc3A-1yt3A:
undetectable		 5uc3A-1yt3A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY

(Vibrio cholerae) 		PF00480
(ROK) 		4 LEU A 127
LEU A 124
MET A 166
TYR A  95
 None
None
None
SO4  A 407 (-4.6A)
 1.10A 5uc3A-1z05A:
undetectable		 5uc3A-1z05A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaj MALONATE
SEMIALDEHYDE
DECARBOXYLASE

(Pseudomonas
pavonaceae) 		PF14552
(Tautomerase_2) 		4 LEU A  20
LEU A  19
MET A  27
TYR A  39
 None
 1.39A 5uc3A-2aajA:
undetectable		 5uc3A-2aajA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3r PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
3-KINASE C2
DOMAIN-CONTAINING
ALPHA POLYPEPTIDE

(Mus musculus) 		PF00168
(C2) 		4 LEU A1465
LEU A1467
MET A1449
TYR A1392
 None
 1.44A 5uc3A-2b3rA:
undetectable		 5uc3A-2b3rA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b92 INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1

(Homo sapiens) 		PF02263
(GBP)
PF02841
(GBP_C) 		4 LEU A 208
LEU A 224
MET A 139
TYR A 204
 LEU  A 208 ( 0.6A)
LEU  A 224 ( 0.6A)
MET  A 139 ( 0.0A)
TYR  A 204 ( 1.3A)
 1.44A 5uc3A-2b92A:
undetectable		 5uc3A-2b92A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE

(Thermus
thermophilus) 		PF00698
(Acyl_transf_1) 		4 LEU A 274
LEU A 277
MET A 257
TYR A   2
 None
 1.43A 5uc3A-2cuyA:
undetectable		 5uc3A-2cuyA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwo RNA SILENCING
SUPPRESSOR

(Beet yellows
virus) 		PF11479
(Suppressor_P21) 		4 LEU A 161
LEU A 163
MET A 175
TYR A 155
 None
 1.29A 5uc3A-2cwoA:
undetectable		 5uc3A-2cwoA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5t ARCHAEAL
TRANSCRIPTIONAL
REGULATOR TRMB

(Thermococcus
litoralis) 		PF11495
(Regulator_TrmB) 		4 LEU X 309
LEU X 289
MET X 256
TYR X 296
 None
 1.46A 5uc3A-2f5tX:
undetectable		 5uc3A-2f5tX:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ilr FANCONI ANEMIA GROUP
E PROTEIN

(Homo sapiens) 		PF11510
(FA_FANCE) 		4 LEU A 402
LEU A 420
MET A 426
TYR A 394
 None
 1.42A 5uc3A-2ilrA:
undetectable		 5uc3A-2ilrA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kb3 OXOGLUTARATE
DEHYDROGENASE
INHIBITOR

(Corynebacterium
glutamicum) 		PF00498
(FHA) 		4 LEU A 135
LEU A  49
GLN A 129
TYR A 111
 None
 1.09A 5uc3A-2kb3A:
undetectable		 5uc3A-2kb3A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nef NEGATIVE FACTOR
(F-PROTEIN)

(Human
immunodeficiency
virus 1) 		PF00469
(F-protein) 		4 LEU A  91
LEU A  97
GLN A 118
TYR A 120
 None
 1.41A 5uc3A-2nefA:
undetectable		 5uc3A-2nefA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		4 LEU A 287
LEU A 289
MET A  65
GLN A 273
 None
 1.24A 5uc3A-2nsmA:
undetectable		 5uc3A-2nsmA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxx UNCHARACTERIZED
PROTEIN MGC2408

(Homo sapiens) 		PF08241
(Methyltransf_11) 		4 LEU A  72
LEU A  76
MET A  97
TYR A  39
 None
None
UNX  A 300 (-3.5A)
None
 1.35A 5uc3A-2pxxA:
undetectable		 5uc3A-2pxxA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus
halodurans) 		PF00268
(Ribonuc_red_sm) 		4 LEU A 110
LEU A 107
MET A  96
GLN A 117
 None
 1.46A 5uc3A-2rccA:
3.1		 5uc3A-2rccA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus) 		PF08241
(Methyltransf_11) 		4 LEU A 116
LEU A 113
MET A  73
GLN A 220
 None
 1.31A 5uc3A-2yr0A:
undetectable		 5uc3A-2yr0A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0f PUTATIVE
PHOSPHOGLUCOMUTASE

(Thermus
thermophilus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 LEU A 416
LEU A 334
MET A 301
GLN A 407
 None
 1.21A 5uc3A-2z0fA:
undetectable		 5uc3A-2z0fA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9s D-ARABINOSE
ISOMERASE

(Aeribacillus
pallidus) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		4 LEU A 278
LEU A 183
MET A 320
TYR A 227
 None
 1.45A 5uc3A-3a9sA:
undetectable		 5uc3A-3a9sA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjb PROBABLE
TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY PROTEIN

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		4 LEU A 196
LEU A 163
MET A 144
TYR A  98
 None
 1.23A 5uc3A-3bjbA:
undetectable		 5uc3A-3bjbA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8z CYSTEINYL-TRNA
SYNTHETASE

(Mycolicibacterium
smegmatis) 		PF01406
(tRNA-synt_1e) 		4 LEU A  64
LEU A  68
MET A  40
TYR A  59
 None
 1.39A 5uc3A-3c8zA:
undetectable		 5uc3A-3c8zA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cze SUCROSE HYDROLASE

(Xanthomonas
citri) 		PF00128
(Alpha-amylase) 		4 LEU A 477
LEU A 476
MET A 484
TYR A 387
 None
 1.35A 5uc3A-3czeA:
undetectable		 5uc3A-3czeA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g77 CYTOSINE DEAMINASE

(Escherichia
coli) 		PF07969
(Amidohydro_3) 		4 LEU A 331
LEU A 352
MET A 341
GLN A 391
 None
 1.31A 5uc3A-3g77A:
undetectable		 5uc3A-3g77A:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9c METHIONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF09334
(tRNA-synt_1g) 		4 LEU A 105
LEU A 108
MET A 308
TYR A 260
 None
 1.21A 5uc3A-3h9cA:
undetectable		 5uc3A-3h9cA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iac GLUCURONATE
ISOMERASE

(Salmonella
enterica) 		PF02614
(UxaC) 		4 LEU A 393
LEU A 434
MET A 411
GLN A 388
 None
 1.42A 5uc3A-3iacA:
undetectable		 5uc3A-3iacA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9d OUTER CAPSID PROTEIN
VP2

(Bluetongue
virus) 		PF00898
(Orbi_VP2) 		4 LEU A 764
LEU A 763
MET A 472
GLN A 810
 None
 1.40A 5uc3A-3j9dA:
undetectable		 5uc3A-3j9dA:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7t 6-HYDROXY-L-NICOTINE
OXIDASE

(Paenarthrobacter
nicotinovorans) 		PF01593
(Amino_oxidase) 		4 LEU A 196
LEU A 192
MET A 167
TYR A  59
 GP7  A 435 ( 4.8A)
GP7  A 435 (-4.5A)
None
None
 0.84A 5uc3A-3k7tA:
undetectable		 5uc3A-3k7tA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ln7 GLUTATHIONE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
GSHAB

(Pasteurella
multocida) 		PF02655
(ATP-grasp_3)
PF04262
(Glu_cys_ligase) 		4 LEU A 157
MET A 178
GLN A 148
TYR A 283
 None
 1.36A 5uc3A-3ln7A:
undetectable		 5uc3A-3ln7A:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkr COATOMER SUBUNIT
ALPHA

(Bos taurus) 		PF06957
(COPI_C) 		4 LEU B 958
LEU B1034
MET B 940
TYR B 963
 None
 1.45A 5uc3A-3mkrB:
undetectable		 5uc3A-3mkrB:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn8 LP15968P

(Drosophila
melanogaster) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		4 LEU A  46
LEU A  76
GLN A 109
TYR A  40
 None
 1.42A 5uc3A-3mn8A:
undetectable		 5uc3A-3mn8A:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n91 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF08522
(DUF1735) 		4 LEU A  43
LEU A 339
MET A 106
TYR A 195
 None
 1.45A 5uc3A-3n91A:
undetectable		 5uc3A-3n91A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzu PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		4 LEU A1027
LEU A1026
MET A1034
TYR A1050
 None
 1.42A 5uc3A-3nzuA:
undetectable		 5uc3A-3nzuA:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojy COMPLEMENT COMPONENT
C8 ALPHA CHAIN

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00090
(TSP_1)
PF01823
(MACPF) 		4 LEU A 446
LEU A 438
MET A 279
GLN A  65
 None
 1.34A 5uc3A-3ojyA:
undetectable		 5uc3A-3ojyA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5p TAXADIENE SYNTHASE

(Taxus
brevifolia) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 LEU A 721
LEU A 725
MET A 658
TYR A 684
 None
 1.41A 5uc3A-3p5pA:
1.9		 5uc3A-3p5pA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pge SUMO-MODIFIED
PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF02747
(PCNA_C)
PF11976
(Rad60-SLD) 		4 LEU A  45
LEU A  48
MET A  60
GLN A  73
 None
 1.36A 5uc3A-3pgeA:
undetectable		 5uc3A-3pgeA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlt GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 2

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 LEU A 183
LEU A 184
MET A 203
GLN A 172
 None
 1.32A 5uc3A-3qltA:
undetectable		 5uc3A-3qltA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rf0 EXOPOLYPHOSPHATASE

(Yersinia pestis) 		no annotation 4 LEU A  55
LEU A  98
GLN A  49
TYR A 124
 None
None
NO3  A 212 (-3.6A)
NO3  A 212 (-4.0A)
 1.27A 5uc3A-3rf0A:
3.2		 5uc3A-3rf0A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5t DUF3298 FAMILY
PROTEIN

(Bacteroides
fragilis) 		PF11738
(DUF3298)
PF13739
(DUF4163) 		4 LEU A 152
LEU A 178
MET A 281
TYR A 236
 None
 1.28A 5uc3A-3s5tA:
undetectable		 5uc3A-3s5tA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sir CASPASE

(Drosophila
melanogaster) 		PF00656
(Peptidase_C14) 		4 LEU A 215
LEU A 214
MET A 195
TYR A 176
 None
 1.32A 5uc3A-3sirA:
undetectable		 5uc3A-3sirA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tig TTL PROTEIN

(Xenopus
tropicalis) 		PF03133
(TTL) 		4 LEU A  71
LEU A  77
GLN A 313
TYR A  64
 None
None
None
MG  A 378 ( 4.6A)
 1.20A 5uc3A-3tigA:
undetectable		 5uc3A-3tigA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE

(Arabidopsis
thaliana;
Vitis vinifera) 		PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C) 		4 LEU A 119
LEU A 120
GLN A 155
TYR A 232
 None
 1.34A 5uc3A-3tsyA:
undetectable		 5uc3A-3tsyA:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vo2 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Zea mays) 		PF00175
(NAD_binding_1) 		4 LEU A 200
LEU A 229
MET A 184
TYR A 270
 None
 1.32A 5uc3A-3vo2A:
undetectable		 5uc3A-3vo2A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0l GLUCOKINASE
REGULATORY PROTEIN

(Xenopus laevis) 		no annotation 4 LEU B  49
LEU B  52
MET B 260
TYR B 493
 None
 1.36A 5uc3A-3w0lB:
3.9		 5uc3A-3w0lB:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akv SORTING NEXIN-33

(Homo sapiens) 		PF00787
(PX)
PF10456
(BAR_3_WASP_bdg) 		4 LEU A 469
LEU A 465
MET A 545
GLN A 476
 None
 1.40A 5uc3A-4akvA:
undetectable		 5uc3A-4akvA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4y NEUROGLOBIN

(Symsagittifera
roscoffensis) 		PF00042
(Globin) 		4 LEU A  86
LEU A  83
MET A 151
GLN A   8
 None
 1.09A 5uc3A-4b4yA:
undetectable		 5uc3A-4b4yA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bsn EXPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		4 LEU A 233
LEU A 230
MET A 213
TYR A 240
 None
 1.43A 5uc3A-4bsnA:
undetectable		 5uc3A-4bsnA:
6.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgs DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 LEU A  11
LEU A  33
MET A  16
TYR A  28
 None
 1.31A 5uc3A-4dgsA:
undetectable		 5uc3A-4dgsA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 LEU A 252
LEU A 256
GLN A 245
TYR A 207
 None
 1.39A 5uc3A-4dxyA:
2.7		 5uc3A-4dxyA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ivi CARBOXYLESTERASE

(uncultured
bacterium) 		PF00144
(Beta-lactamase) 		4 LEU A 113
LEU A 119
MET A 332
TYR A 323
 None
 1.09A 5uc3A-4iviA:
undetectable		 5uc3A-4iviA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Oncorhynchus
mykiss) 		PF00079
(Serpin) 		4 LEU A  87
LEU A 163
MET A  42
GLN A 112
 None
 1.36A 5uc3A-4kdsA:
undetectable		 5uc3A-4kdsA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4km3 METHIONINE
AMINOPEPTIDASE

(Streptococcus
pneumoniae) 		PF00557
(Peptidase_M24) 		4 LEU A  27
LEU A  30
GLN A 280
TYR A 286
 None
 1.28A 5uc3A-4km3A:
undetectable		 5uc3A-4km3A:
14.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 563
LEU A 566
MET A 601
TYR A 735
 MOF  A 801 (-3.9A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.8A)
 1.01A 5uc3A-4p6wA:
34.1		 5uc3A-4p6wA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psp ALPHA-FUCOSIDASE
GH29

(Fusarium
graminearum) 		PF01120
(Alpha_L_fucos)
PF16757
(Fucosidase_C) 		4 LEU A 340
MET A 325
GLN A 355
TYR A 319
 None
 1.43A 5uc3A-4pspA:
undetectable		 5uc3A-4pspA:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4quv DELTA(14)-STEROL
REDUCTASE

(Methylomicrobium
alcaliphilum) 		PF01222
(ERG4_ERG24) 		4 LEU A 214
LEU A 210
MET A 231
TYR A 221
 None
 1.30A 5uc3A-4quvA:
undetectable		 5uc3A-4quvA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trq NUCLEAR MRNA EXPORT
PROTEIN SAC3
NUCLEAR MRNA EXPORT
PROTEIN THP1

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF03399
(SAC3_GANP) 		4 LEU B 232
LEU B 231
GLN A 378
TYR A 379
 None
 1.39A 5uc3A-4trqB:
undetectable		 5uc3A-4trqB:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgt FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 LEU A 992
LEU A 988
MET A1049
GLN A1039
 None
 1.34A 5uc3A-4xgtA:
undetectable		 5uc3A-4xgtA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjx HSDR

(Escherichia
coli) 		PF04313
(HSDR_N)
PF04851
(ResIII)
PF12008
(EcoR124_C) 		4 LEU A 253
LEU A 257
MET A 130
GLN A  47
 None
 1.16A 5uc3A-4xjxA:
undetectable		 5uc3A-4xjxA:
6.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE

(Schizosaccharomyces
pombe) 		PF03031
(NIF)
PF12738
(PTCB-BRCT) 		4 LEU A 391
LEU A 387
MET A 424
TYR A 398
 None
 1.02A 5uc3A-4xpzA:
undetectable		 5uc3A-4xpzA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpx ATP-DEPENDENT
PROTEASE LON

(Thermococcus
onnurineus) 		PF01078
(Mg_chelatase)
PF13654
(AAA_32) 		4 LEU A 292
LEU A 242
MET A  80
TYR A 317
 None
 1.41A 5uc3A-4zpxA:
undetectable		 5uc3A-4zpxA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrs ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 LEU A 224
LEU A 222
MET A 280
TYR A 257
 None
GOL  A 301 (-4.5A)
None
None
 1.41A 5uc3A-4zrsA:
undetectable		 5uc3A-4zrsA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		4 LEU A1975
LEU A1984
MET A2079
TYR A1934
 None
 1.37A 5uc3A-5a22A:
undetectable		 5uc3A-5a22A:
3.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 LEU A1609
LEU A1612
MET A1373
TYR A1589
 None
 1.17A 5uc3A-5a31A:
undetectable		 5uc3A-5a31A:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 LEU A 343
LEU A 340
MET A 328
TYR A 347
 None
 1.43A 5uc3A-5ci6A:
undetectable		 5uc3A-5ci6A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cqb DITRANS,POLYCIS-UNDE
CAPRENYL-DIPHOSPHATE
SYNTHASE
((2E,6E)-FARNESYL-DI
PHOSPHATE SPECIFIC)

(Escherichia
coli) 		PF01255
(Prenyltransf) 		4 LEU A  65
LEU A 137
MET A 183
TYR A  68
 None
 1.45A 5uc3A-5cqbA:
undetectable		 5uc3A-5cqbA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hss LINALOOL
DEHYDRATASE/ISOMERAS
E

(Castellaniella
defragrans) 		no annotation 4 LEU A 131
LEU A 185
MET A 361
TYR A 136
 None
 1.30A 5uc3A-5hssA:
undetectable		 5uc3A-5hssA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1w CRMK

(Actinoalloteichus
sp. WH1-2216-6) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 LEU A 347
LEU A 400
MET A 375
GLN A 355
 None
 1.35A 5uc3A-5i1wA:
undetectable		 5uc3A-5i1wA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iw7 RIBOSOME BIOGENESIS
PROTEIN
TSR1,RIBOSOME
BIOGENESIS PROTEIN
TSR1

(Saccharomyces
cerevisiae) 		PF04950
(RIBIOP_C)
PF08142
(AARP2CN) 		4 LEU A 584
LEU A 292
MET A 559
TYR A 258
 None
 1.11A 5uc3A-5iw7A:
undetectable		 5uc3A-5iw7A:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA

(Homo sapiens) 		no annotation 4 LEU B  51
LEU B  88
MET B 632
GLN B 610
 None
 1.28A 5uc3A-5iz5B:
undetectable		 5uc3A-5iz5B:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jq9 DIHYDROPTEROATE
SYNTHASE

(Yersinia pestis) 		PF00809
(Pterin_bind) 		4 LEU A 214
LEU A 184
MET A 158
GLN A 249
 None
 1.19A 5uc3A-5jq9A:
undetectable		 5uc3A-5jq9A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5n PLEXIN-A4

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		4 LEU A 382
LEU A 412
MET A 417
GLN A 259
 LEU  A 382 ( 0.5A)
LEU  A 412 ( 0.5A)
MET  A 417 ( 0.0A)
GLN  A 259 ( 0.6A)
 1.46A 5uc3A-5l5nA:
undetectable		 5uc3A-5l5nA:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 LEU A1609
LEU A1612
MET A1373
TYR A1589
 None
 1.18A 5uc3A-5lcwA:
undetectable		 5uc3A-5lcwA:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lub LEGUMAIN

(Homo sapiens) 		no annotation 4 LEU B 161
LEU B 154
MET B  69
GLN B 111
 None
 1.20A 5uc3A-5lubB:
undetectable		 5uc3A-5lubB:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojy TETR FAMILY
TRANSCRIPTION
REGULATOR

(Streptomyces
alboniger) 		no annotation 4 LEU A 160
LEU A 156
MET A 237
TYR A 166
 None
 1.25A 5uc3A-5ojyA:
3.3		 5uc3A-5ojyA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy1 STRA6

(Danio rerio) 		PF14752
(RBP_receptor) 		4 LEU A 357
LEU A 358
MET A 414
TYR A 287
 None
 1.27A 5uc3A-5sy1A:
undetectable		 5uc3A-5sy1A:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t12 PHOSPHOENOLPYRUVATE-
-PROTEIN
PHOSPHOTRANSFERASE

(Escherichia
coli) 		PF00391
(PEP-utilizers)
PF05524
(PEP-utilisers_N) 		4 LEU A 338
LEU A 343
MET A 360
GLN A 303
 None
None
None
IOD  A 501 ( 4.4A)
 1.23A 5uc3A-5t12A:
undetectable		 5uc3A-5t12A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		4 LEU A 542
LEU A 546
MET A 591
GLN A 538
 None
 1.33A 5uc3A-5t8vA:
undetectable		 5uc3A-5t8vA:
4.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 4 LEU A 559
LEU A 562
MET A 597
GLN A 638
 486  A 801 (-4.7A)
486  A 801 ( 4.8A)
CPS  A 803 ( 3.9A)
486  A 801 (-4.6A)
 0.98A 5uc3A-5uc1A:
28.2		 5uc3A-5uc1A:
96.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhf DNA-DIRECTED RNA
POLYMERASE SUBUNIT
OMEGA

(Mycobacterium
tuberculosis) 		PF01192
(RNA_pol_Rpb6) 		4 LEU E 104
LEU E 103
GLN E  63
TYR E  78
 None
 1.25A 5uc3A-5uhfE:
undetectable		 5uc3A-5uhfE:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vk1 PROTEIN MDM4

(Homo sapiens) 		no annotation 4 LEU A  85
LEU A  81
MET A  53
TYR A  99
 None
 1.40A 5uc3A-5vk1A:
undetectable		 5uc3A-5vk1A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z96 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 4

(Mus musculus) 		no annotation 4 LEU A 513
LEU A 517
MET A 437
GLN A 506
 LPP  A 802 (-4.3A)
None
None
None
 1.38A 5uc3A-5z96A:
undetectable		 5uc3A-5z96A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5

(Aquareovirus C) 		no annotation 4 LEU 4 347
LEU 4 351
MET 4 424
GLN 4 337
 None
 1.13A 5uc3A-5zvs4:
undetectable		 5uc3A-5zvs4:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6axf RAS GUANYL-RELEASING
PROTEIN 2

(Homo sapiens) 		no annotation 4 LEU A 314
LEU A 318
MET A  42
TYR A 178
 None
 1.34A 5uc3A-6axfA:
undetectable		 5uc3A-6axfA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b07 FARNESYL DIPHOSPHATE
SYNTHASE

(Choristoneura
fumiferana) 		no annotation 4 LEU A 256
LEU A 132
GLN A 251
TYR A 247
 None
 1.40A 5uc3A-6b07A:
undetectable		 5uc3A-6b07A:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co1 TUDOR-INTERACTING
REPAIR REGULATOR
PROTEIN

(Homo sapiens) 		no annotation 4 LEU A 161
LEU A 192
MET A 183
TYR A 148
 None
 1.34A 5uc3A-6co1A:
undetectable		 5uc3A-6co1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
GAMMA-2,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT GAMMA-2

(Homo sapiens) 		no annotation 4 LEU E 246
LEU E 250
MET E 276
TYR E 241
 None
 1.46A 5uc3A-6d6uE:
undetectable		 5uc3A-6d6uE:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emp -

(-) 		no annotation 4 LEU A 380
LEU A 383
MET A 426
TYR A 420
 None
 1.30A 5uc3A-6empA:
undetectable		 5uc3A-6empA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emq -

(-) 		no annotation 4 LEU A 380
LEU A 383
MET A 426
TYR A 420
 None
 1.35A 5uc3A-6emqA:
undetectable		 5uc3A-6emqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE DELTA
SUBUNIT
ATP SYNTHASE GAMMA
SUBUNIT

(Trypanosoma
brucei) 		no annotation 4 LEU G 223
LEU G 226
MET H  14
TYR G  48
 None
 1.24A 5uc3A-6f5dG:
undetectable		 5uc3A-6f5dG:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 4 LEU A1973
LEU A1972
GLN A2238
TYR A2254
 None
 1.42A 5uc3A-6fb3A:
undetectable		 5uc3A-6fb3A:
22.35