SIMILAR PATTERNS OF AMINO ACIDS FOR 5UC1_B_486B801_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b24 PROTEIN (I-DMOI)

(Desulfurococcus
mucosus) 		PF14528
(LAGLIDADG_3) 		3 TRP A 141
MET A 103
ASN A 102
 None
 1.45A 5uc1A-1b24A:
0.0		 5uc1A-1b24A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cn3 COAT PROTEIN VP1

(Polyomavirus
sp.) 		PF00718
(Polyoma_coat) 		3 TRP A 120
MET A 119
ASN A 109
 None
 1.45A 5uc1A-1cn3A:
undetectable		 5uc1A-1cn3A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cqd PROTEIN (PROTEASE
II)

(Zingiber
officinale) 		PF00112
(Peptidase_C1) 		3 TRP A  28
MET A  70
ASN A  71
 None
 1.28A 5uc1A-1cqdA:
0.0		 5uc1A-1cqdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE B

(Bacillus
subtilis) 		PF14682
(SPOB_ab)
PF14689
(SPOB_a) 		3 TRP A  32
MET A  33
ASN A  34
 None
None
MG  E2001 ( 4.6A)
 1.18A 5uc1A-1f51A:
0.0		 5uc1A-1f51A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE

(Medicago sativa) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		3 TRP A 148
MET A 149
ASN A 150
 None
 0.90A 5uc1A-1fpqA:
0.7		 5uc1A-1fpqA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gnz GSI-B4 ISOLECTIN

(Griffonia
simplicifolia) 		PF00139
(Lectin_legB) 		3 TRP A  61
MET A 204
ASN A 207
 None
 1.41A 5uc1A-1gnzA:
undetectable		 5uc1A-1gnzA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		3 TRP A 697
MET A 651
ASN A 648
 None
 1.32A 5uc1A-1h7wA:
0.0		 5uc1A-1h7wA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcf BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07679
(I-set) 		3 TRP X 301
MET X 379
ASN X 356
 None
 1.16A 5uc1A-1hcfX:
undetectable		 5uc1A-1hcfX:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwd ERVATAMIN B

(Tabernaemontana
divaricata) 		PF00112
(Peptidase_C1) 		3 TRP A  26
MET A  68
ASN A  69
 None
 1.13A 5uc1A-1iwdA:
0.0		 5uc1A-1iwdA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwl OUTER-MEMBRANE
LIPOPROTEINS CARRIER
PROTEIN

(Escherichia
coli) 		PF03548
(LolA) 		3 TRP A  49
MET A  91
ASN A  87
 None
 1.31A 5uc1A-1iwlA:
0.0		 5uc1A-1iwlA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js1 TRANSCARBAMYLASE

(Bacteroides
fragilis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 TRP X 191
MET X 192
ASN X 193
 None
 1.49A 5uc1A-1js1X:
0.0		 5uc1A-1js1X:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 TRP A 364
MET A 608
ASN A 611
 None
 1.02A 5uc1A-1kcwA:
undetectable		 5uc1A-1kcwA:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER

(Escherichia
coli) 		PF07690
(MFS_1) 		3 TRP A 340
MET A 341
ASN A 342
 None
 1.21A 5uc1A-1pw4A:
undetectable		 5uc1A-1pw4A:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B

([Haemophilus]
ducreyi) 		PF03372
(Exo_endo_phos) 		3 TRP B  93
MET B 103
ASN B 102
 None
BR  B 512 (-4.4A)
None
 1.37A 5uc1A-1sr4B:
undetectable		 5uc1A-1sr4B:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sva SIMIAN VIRUS 40

(Macaca mulatta
polyomavirus 1) 		PF00718
(Polyoma_coat) 		3 TRP 1 110
MET 1 109
ASN 1  99
 None
 1.31A 5uc1A-1sva1:
undetectable		 5uc1A-1sva1:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE

(Thermotoga
maritima) 		PF01008
(IF-2B) 		3 TRP A 219
MET A 216
ASN A 215
 None
 1.20A 5uc1A-1t9kA:
undetectable		 5uc1A-1t9kA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwi BETA-GALACTOSIDASE

(Sulfolobus
solfataricus) 		PF00232
(Glyco_hydro_1) 		3 TRP A 151
MET A 204
ASN A 147
 None
 1.49A 5uc1A-1uwiA:
undetectable		 5uc1A-1uwiA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwy CARBOXYPEPTIDASE M

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		3 TRP A 241
MET A 229
ASN A 230
 None
 1.46A 5uc1A-1uwyA:
undetectable		 5uc1A-1uwyA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yew PARTICULATE METHANE
MONOOXYGENASE
SUBUNIT C2

(Methylococcus
capsulatus) 		PF04896
(AmoC) 		3 TRP C  89
MET C  90
ASN C  91
 None
 1.32A 5uc1A-1yewC:
undetectable		 5uc1A-1yewC:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9s TOPOISOMERASE I-LIKE
PROTEIN

(Leishmania
donovani) 		PF01028
(Topoisom_I)
PF02919
(Topoisom_I_N) 		3 TRP A 238
MET A 254
ASN A 178
 None
 1.25A 5uc1A-2b9sA:
undetectable		 5uc1A-2b9sA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb0 IMIDAZOLONEPROPIONAS
E

(Bacillus
subtilis) 		PF01979
(Amidohydro_1) 		3 TRP A 354
MET A 391
ASN A 389
 None
 1.50A 5uc1A-2bb0A:
undetectable		 5uc1A-2bb0A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)

(Paracoccus
denitrificans) 		PF06433
(Me-amine-dh_H) 		3 TRP H 127
MET H 128
ASN H  69
 None
 0.95A 5uc1A-2bbkH:
undetectable		 5uc1A-2bbkH:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0h MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Mytilus edulis) 		PF00150
(Cellulase) 		3 TRP A 126
MET A 142
ASN A 139
 None
 1.15A 5uc1A-2c0hA:
undetectable		 5uc1A-2c0hA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6a UBIQUITIN-PROTEIN
LIGASE E3 MDM2

(Homo sapiens) 		PF00641
(zf-RanBP) 		3 TRP A 303
MET A 311
ASN A 309
 None
 1.27A 5uc1A-2c6aA:
undetectable		 5uc1A-2c6aA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4c BICARBONATE
TRANSPORTER

(Synechocystis
sp. PCC 6803) 		PF13379
(NMT1_2) 		3 TRP A 120
MET A 122
ASN A 197
 None
 0.83A 5uc1A-2i4cA:
undetectable		 5uc1A-2i4cA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ifg HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF13855
(LRR_8)
PF16920
(TPKR_C2) 		3 TRP A 299
MET A 379
ASN A 356
 None
 1.02A 5uc1A-2ifgA:
undetectable		 5uc1A-2ifgA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaj PROTEIN SNI1

(Saccharomyces
cerevisiae) 		PF08596
(Lgl_C) 		3 TRP A 298
MET A 307
ASN A 317
 None
 1.45A 5uc1A-2oajA:
undetectable		 5uc1A-2oajA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ret PSEUDOPILIN EPSI

(Vibrio
vulnificus) 		PF02501
(T2SSI) 		3 TRP A  72
MET A  42
ASN A  46
 None
 1.50A 5uc1A-2retA:
undetectable		 5uc1A-2retA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8n LACTOSE PERMEASE

(Escherichia
coli) 		PF01306
(LacY_symp) 		3 TRP A  10
MET A  11
ASN A   8
 None
 0.81A 5uc1A-2v8nA:
undetectable		 5uc1A-2v8nA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		3 TRP A 321
MET A 324
ASN A 254
 None
 1.46A 5uc1A-2vcaA:
undetectable		 5uc1A-2vcaA:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgy RELIK CAPSID
N-TERMINAL DOMAIN

(Oryctolagus
cuniculus) 		PF00607
(Gag_p24) 		3 TRP A  22
MET A  54
ASN A  57
 None
None
GOL  A1138 (-4.0A)
 1.48A 5uc1A-2xgyA:
undetectable		 5uc1A-2xgyA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE

(Streptomyces
avermitilis) 		PF00652
(Ricin_B_lectin)
PF16499
(Melibiase_2) 		3 TRP A 303
MET A 300
ASN A 296
 None
 1.48A 5uc1A-3a21A:
undetectable		 5uc1A-3a21A:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		3 TRP A 423
MET A 388
ASN A 419
 None
 1.37A 5uc1A-3cttA:
undetectable		 5uc1A-3cttA:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3es1 CUPIN 2, CONSERVED
BARREL DOMAIN
PROTEIN

(Novosphingobium
aromaticivorans) 		PF07883
(Cupin_2) 		3 TRP A 136
MET A  85
ASN A 138
 None
 1.40A 5uc1A-3es1A:
undetectable		 5uc1A-3es1A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f1s VITAMIN K-DEPENDENT
PROTEIN Z

(Homo sapiens) 		PF00089
(Trypsin)
PF14670
(FXa_inhibition) 		3 TRP B 354
MET B 211
ASN B 220
 None
 1.39A 5uc1A-3f1sB:
undetectable		 5uc1A-3f1sB:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f75 CATHEPSIN L PROTEASE

(Toxoplasma
gondii) 		PF00112
(Peptidase_C1) 		3 TRP A  32
MET A  76
ASN A  77
 None
 1.29A 5uc1A-3f75A:
undetectable		 5uc1A-3f75A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1

(Schizosaccharomyces
pombe) 		PF04857
(CAF1) 		3 TRP A 105
MET A  34
ASN A  35
 None
 1.32A 5uc1A-3g10A:
undetectable		 5uc1A-3g10A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5c VITAMIN K-DEPENDENT
PROTEIN Z

(Homo sapiens) 		PF00008
(EGF)
PF00089
(Trypsin)
PF14670
(FXa_inhibition) 		3 TRP B 354
MET B 211
ASN B 220
 None
 1.34A 5uc1A-3h5cB:
undetectable		 5uc1A-3h5cB:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml0 PENICILLIN G
ACYLASE, BETA
SUBUNIT

(Alcaligenes
faecalis) 		PF01804
(Penicil_amidase) 		3 TRP B 240
MET B 262
ASN B 263
 None
 1.50A 5uc1A-3ml0B:
undetectable		 5uc1A-3ml0B:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qef BETA-XYLOSIDASE/ALPH
A-L-ARABINFURANOSIDA
SE, GLY43N

(Cellvibrio
japonicus) 		PF04616
(Glyco_hydro_43) 		3 TRP A  72
MET A  69
ASN A  70
 None
EDO  A 336 (-3.6A)
None
 1.48A 5uc1A-3qefA:
undetectable		 5uc1A-3qefA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qj3 CATHEPSIN L-LIKE
PROTEIN

(Tenebrio
molitor) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		3 TRP A 130
MET A 174
ASN A 175
 None
 1.33A 5uc1A-3qj3A:
undetectable		 5uc1A-3qj3A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		3 TRP A 235
MET A 308
ASN A 306
 SO4  A 701 ( 4.8A)
None
None
 0.54A 5uc1A-3vueA:
undetectable		 5uc1A-3vueA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy8 SERINE PROTEASE

(Paenarthrobacter
nicotinovorans) 		no annotation 3 TRP A  72
MET A  98
ASN A  99
 None
 1.09A 5uc1A-3wy8A:
undetectable		 5uc1A-3wy8A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wz3 TRAM PROTEIN

(Plasmid R64) 		PF11393
(T4BSS_DotI_IcmL) 		3 TRP A 176
MET A  97
ASN A  94
 None
 1.31A 5uc1A-3wz3A:
undetectable		 5uc1A-3wz3A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs6 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Burkholderia
pseudomallei) 		PF00496
(SBP_bac_5) 		3 TRP A  73
MET A 543
ASN A 539
 None
 0.83A 5uc1A-3zs6A:
undetectable		 5uc1A-3zs6A:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apl APICAL MEMBRANE
ANTIGEN 1

(Neospora
caninum) 		PF02430
(AMA-1) 		3 TRP A 347
MET A 155
ASN A 154
 None
 1.14A 5uc1A-4aplA:
undetectable		 5uc1A-4aplA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f02 POLYADENYLATE-BINDIN
G PROTEIN 1

(Homo sapiens) 		PF00076
(RRM_1) 		3 TRP A  86
MET A  85
ASN A  73
 None
A  B   6 (-3.3A)
None
 1.22A 5uc1A-4f02A:
undetectable		 5uc1A-4f02A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fas HYDROXYLAMINE
OXIDOREDUCTASE

(Nitrosomonas
europaea) 		PF13447
(Multi-haem_cyto) 		3 TRP A 271
MET A 276
ASN A 461
 None
 1.43A 5uc1A-4fasA:
undetectable		 5uc1A-4fasA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3f SERINE HYDROLASE
CCSP0084

(Cycloclasticus
sp. P1) 		PF12697
(Abhydrolase_6) 		3 TRP A  42
MET A  39
ASN A  37
 None
 1.27A 5uc1A-4i3fA:
undetectable		 5uc1A-4i3fA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im4 ENDOGLUCANASE E

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase) 		3 TRP A 172
MET A 191
ASN A 218
 None
 1.36A 5uc1A-4im4A:
undetectable		 5uc1A-4im4A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3y NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 TRP A 178
MET A 156
ASN A 157
 None
 1.48A 5uc1A-4k3yA:
undetectable		 5uc1A-4k3yA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qh6 CRUZIPAIN

(Trypanosoma
cruzi) 		PF00112
(Peptidase_C1) 		3 TRP A  26
MET A  68
ASN A  69
 None
33L  A 301 (-3.6A)
None
 1.24A 5uc1A-4qh6A:
undetectable		 5uc1A-4qh6A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qwv HIGH-AFFINITY
LEUCINE-SPECIFIC
TRANSPORT SYSTEM
PERIPLASMIC BINDING
PROTEIN, CHEMOTAXIS
PROTEIN CHEY

(Escherichia
coli;
Thermotoga
maritima) 		PF00072
(Response_reg)
PF13458
(Peripla_BP_6) 		3 TRP A 270
MET A  21
ASN A  24
 None
 1.45A 5uc1A-4qwvA:
undetectable		 5uc1A-4qwvA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Pseudarthrobacter
chlorophenolicus) 		PF01547
(SBP_bac_1) 		3 TRP A  64
MET A 362
ASN A 363
 None
 1.45A 5uc1A-4r2fA:
undetectable		 5uc1A-4r2fA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ums CELLULOSOMAL
ANCHORING SCAFFOLDIN
B

(Pseudobacteroides
cellulosolvens) 		PF00963
(Cohesin) 		3 TRP A1041
MET A1042
ASN A1043
 None
 1.44A 5uc1A-4umsA:
undetectable		 5uc1A-4umsA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		3 TRP A 253
MET A 205
ASN A 230
 SO4  A 712 ( 4.5A)
None
None
 1.18A 5uc1A-4z64A:
undetectable		 5uc1A-4z64A:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7x MDBA

(Actinomyces
oris) 		PF13462
(Thioredoxin_4) 		3 TRP A 176
MET A 181
ASN A 182
 None
 1.12A 5uc1A-4z7xA:
undetectable		 5uc1A-4z7xA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az4 FLAGELLAR HOOK
SUBUNIT PROTEIN

(Campylobacter
jejuni) 		PF07196
(Flagellin_IN)
PF07559
(FlaE) 		3 TRP A 256
MET A 360
ASN A 350
 None
 1.31A 5uc1A-5az4A:
undetectable		 5uc1A-5az4A:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwd BENZYLSUCCINATE
SYNTHASE ALPHA CHAIN

(Thauera
aromatica) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 TRP A 613
MET A 494
ASN A 490
 FUM  A 901 (-4.5A)
None
None
 1.45A 5uc1A-5bwdA:
undetectable		 5uc1A-5bwdA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9s RRNA BIOGENESIS
PROTEIN RRP5

(Saccharomyces
cerevisiae) 		no annotation 3 TRP B1478
MET B1479
ASN B1480
 None
 0.90A 5uc1A-5c9sB:
undetectable		 5uc1A-5c9sB:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0c CELLULASE

(Bacillus sp.
BG-CS10) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		3 TRP A  64
MET A  68
ASN A  66
 None
 1.39A 5uc1A-5e0cA:
undetectable		 5uc1A-5e0cA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqn FRBJ

(Streptomyces
rubellomurinus) 		PF02668
(TauD) 		3 TRP A  15
MET A 177
ASN A 181
 None
 1.18A 5uc1A-5eqnA:
undetectable		 5uc1A-5eqnA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxe EUGENOL OXIDASE

(Rhodococcus
jostii) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		3 TRP A 384
MET A 282
ASN A 279
 None
CIY  A 602 ( 4.0A)
None
 1.11A 5uc1A-5fxeA:
undetectable		 5uc1A-5fxeA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gll GLYCOSIDE HYDROLASE
FAMILY 43

(uncultured
bacterium) 		PF04616
(Glyco_hydro_43) 		3 TRP A 196
MET A  84
ASN A  82
 None
 1.40A 5uc1A-5gllA:
undetectable		 5uc1A-5gllA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4r BETA-1,3-1,4-GLUCANA
SE

(Caldicellulosiruptor
sp. F32) 		PF00150
(Cellulase) 		3 TRP A 199
MET A 202
ASN A 203
 None
 1.46A 5uc1A-5h4rA:
undetectable		 5uc1A-5h4rA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL

(Oryctolagus
cuniculus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		3 TRP A 833
MET A 834
ASN A 835
 None
 0.98A 5uc1A-5h53A:
undetectable		 5uc1A-5h53A:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5m RNA DEPENDENT RNA
POLYMERASE

(Dengue virus) 		PF00972
(Flavi_NS5) 		3 TRP A 478
MET A 477
ASN A 453
 None
 1.39A 5uc1A-5k5mA:
undetectable		 5uc1A-5k5mA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9s ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (MANNOPINE)

(Agrobacterium
fabrum) 		PF13416
(SBP_bac_8) 		3 TRP A 183
MET A 348
ASN A 345
 None
 1.42A 5uc1A-5l9sA:
undetectable		 5uc1A-5l9sA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loa MESO-DIAMINOPIMELATE
D-DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF16654
(DAPDH_C) 		3 TRP A 119
MET A 123
ASN A 127
 NAP  A 401 (-4.2A)
None
None
 1.20A 5uc1A-5loaA:
undetectable		 5uc1A-5loaA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 3 TRP A 363
MET A 602
ASN A 605
 None
 1.19A 5uc1A-5n4lA:
undetectable		 5uc1A-5n4lA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwm RRNA BIOGENESIS
PROTEIN RRP5

(Saccharomyces
cerevisiae) 		no annotation 3 TRP A1478
MET A1479
ASN A1480
 None
 0.90A 5uc1A-5wwmA:
undetectable		 5uc1A-5wwmA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		3 TRP C2245
MET C2220
ASN C2217
 None
 1.45A 5uc1A-5y3rC:
undetectable		 5uc1A-5y3rC:
1.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbj TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL, SUBFAMILY
V, MEMBER 4

(Xenopus
tropicalis) 		no annotation 3 TRP A 582
MET A 583
ASN A 584
 None
 0.95A 5uc1A-6bbjA:
undetectable		 5uc1A-6bbjA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8g TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL, SUBFAMILY
V, MEMBER 4

(Xenopus
tropicalis) 		no annotation 3 TRP A 582
MET A 583
ASN A 584
 None
 0.93A 5uc1A-6c8gA:
undetectable		 5uc1A-6c8gA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f74 ALCOHOL OXIDASE

(Thermothelomyces
thermophila) 		no annotation 3 TRP A 493
MET A 541
ASN A 542
 None
None
FAD  A 601 (-4.1A)
 1.23A 5uc1A-6f74A:
undetectable		 5uc1A-6f74A:
17.39