SIMILAR PATTERNS OF AMINO ACIDS FOR 5UC1_A_486A801

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A 212
GLY A 184
GLY A 183
VAL A 181
CYH A 358
 None
 1.07A 5uc1A-1ebdA:
undetectable		 5uc1A-1ebdA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5b SERINE/THREONINE
PROTEIN PHOSPHATASE

(Escherichia
virus Lambda) 		PF00149
(Metallophos) 		5 LEU A  21
LEU A  50
GLY A  48
VAL A  72
LEU A  44
 None
 1.10A 5uc1A-1g5bA:
undetectable		 5uc1A-1g5bA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1id8 METHYLASPARTATE
MUTASE S CHAIN

(Clostridium
tetanomorphum) 		PF02310
(B12-binding) 		5 LEU A  23
GLY A  91
GLY A  92
VAL A 116
LEU A  57
 DBI  A 139 (-4.3A)
DBI  A 139 (-2.7A)
DBI  A 139 ( 3.5A)
None
None
 1.20A 5uc1A-1id8A:
undetectable		 5uc1A-1id8A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m33 BIOH PROTEIN

(Escherichia
coli) 		PF00561
(Abhydrolase_1) 		5 LEU A 183
LEU A 180
GLY A 179
GLY A 178
VAL A 175
 3OH  A 300 (-4.3A)
None
None
None
None
 0.76A 5uc1A-1m33A:
undetectable		 5uc1A-1m33A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnt OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		5 GLY A  62
GLY A  61
GLN A  63
LEU A 119
ARG A 184
 None
 1.10A 5uc1A-1nntA:
undetectable		 5uc1A-1nntA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogo DEXTRANASE

(Talaromyces
minioluteus) 		PF03718
(Glyco_hydro_49)
PF17433
(Glyco_hydro_49N) 		5 LEU X 270
GLY X 292
GLY X 339
VAL X 338
MET X 210
 None
 1.03A 5uc1A-1ogoX:
undetectable		 5uc1A-1ogoX:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sw6 REGULATORY PROTEIN
SWI6

(Saccharomyces
cerevisiae) 		PF00023
(Ank)
PF13857
(Ank_5) 		5 LEU A 412
LEU A 415
GLY A 417
VAL A 420
LEU A 463
 None
 0.87A 5uc1A-1sw6A:
undetectable		 5uc1A-1sw6A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szp DNA REPAIR PROTEIN
RAD51

(Saccharomyces
cerevisiae) 		PF08423
(Rad51)
PF14520
(HHH_5) 		5 LEU A 194
LEU A 198
VAL A 321
LEU A 171
CYH A 370
 None
 1.20A 5uc1A-1szpA:
undetectable		 5uc1A-1szpA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU B 168
LEU B 165
GLY B 338
GLY B 337
LEU B 400
 None
 1.09A 5uc1A-1tqyB:
undetectable		 5uc1A-1tqyB:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ued P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		5 LEU A 161
LEU A 242
GLY A 245
LEU A 361
MET A 365
 None
HEM  A1430 ( 4.5A)
PG4  A4502 ( 3.7A)
HEM  A1430 ( 4.9A)
None
 1.09A 5uc1A-1uedA:
undetectable		 5uc1A-1uedA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un9 DIHYDROXYACETONE
KINASE

(Citrobacter
freundii) 		PF02733
(Dak1)
PF02734
(Dak2) 		5 LEU A 143
GLY A 216
GLY A 190
VAL A 191
ARG A 207
 None
 1.18A 5uc1A-1un9A:
undetectable		 5uc1A-1un9A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woi AGMATINASE

(Deinococcus
radiodurans) 		PF00491
(Arginase) 		5 LEU A 117
GLY A 118
GLY A 119
VAL A 123
LEU A 270
 None
 1.19A 5uc1A-1woiA:
undetectable		 5uc1A-1woiA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybf AMP NUCLEOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01048
(PNP_UDP_1) 		5 LEU A 102
GLY A  99
GLY A  98
VAL A 184
TRP A 166
 None
 1.17A 5uc1A-1ybfA:
undetectable		 5uc1A-1ybfA:
17.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 704
GLY A 708
GLN A 711
MET A 745
ARG A 752
CYH A 784
MET A 787
 BHM  A   1 (-4.0A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 (-3.9A)
BHM  A   1 (-3.8A)
None
BHM  A   1 (-3.6A)
 0.95A 5uc1A-2ax9A:
22.5		 5uc1A-2ax9A:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 704
LEU A 707
GLY A 708
GLN A 711
ARG A 752
CYH A 784
MET A 787
 BHM  A   1 (-4.0A)
BHM  A   1 ( 4.2A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 (-3.8A)
None
BHM  A   1 (-3.6A)
 0.73A 5uc1A-2ax9A:
22.5		 5uc1A-2ax9A:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw7 ENDONUCLEASE
PI-PKOII

(Thermococcus
kodakarensis) 		PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		5 LEU A 278
LEU A 281
GLY A 283
VAL A 286
LEU A 346
 None
 0.61A 5uc1A-2cw7A:
undetectable		 5uc1A-2cw7A:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4o XP-C REPAIR
COMPLEMENTING
COMPLEX 58 KDA
PROTEIN

(Mus musculus) 		PF09280
(XPC-binding) 		5 LEU B 313
LEU B 314
GLY B 307
LEU B 302
MET B 288
 None
 1.20A 5uc1A-2f4oB:
undetectable		 5uc1A-2f4oB:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h39 PROBABLE
GALACTOSE-1-PHOSPHAT
E URIDYL TRANSFERASE

(Arabidopsis
thaliana) 		PF01087
(GalP_UDP_transf)
PF02744
(GalP_UDP_tr_C) 		5 LEU A 276
LEU A 273
GLY A 272
GLY A 271
VAL A 268
 None
 0.92A 5uc1A-2h39A:
undetectable		 5uc1A-2h39A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i79 ACETYLTRANSFERASE,
GNAT FAMILY

(Streptococcus
pneumoniae) 		PF00583
(Acetyltransf_1) 		5 LEU A  90
LEU A 126
GLY A 168
VAL A 145
LEU A 138
 None
ACO  A 402 (-4.1A)
None
None
ACO  A 402 ( 4.5A)
 0.95A 5uc1A-2i79A:
undetectable		 5uc1A-2i79A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1o GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sinapis alba) 		PF00348
(polyprenyl_synt) 		5 LEU A  73
GLY A 208
GLY A 209
VAL A  67
CYH A  79
 None
 1.13A 5uc1A-2j1oA:
2.4		 5uc1A-2j1oA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE

(Arabidopsis
thaliana) 		PF01487
(DHquinase_I)
PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 LEU A 276
GLY A 275
GLY A 272
VAL A 270
LEU A 281
 None
 1.21A 5uc1A-2o7qA:
undetectable		 5uc1A-2o7qA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 346
LEU A 349
TRP A 383
LEU A 391
ARG A 394
 EST  A 596 (-4.4A)
EST  A 596 ( 4.1A)
None
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
 0.78A 5uc1A-2ocfA:
22.6		 5uc1A-2ocfA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Polaromonas sp.
JS666) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 204
GLY A 180
GLY A 179
MET A 211
LEU A 183
 None
 1.18A 5uc1A-2og9A:
undetectable		 5uc1A-2og9A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9b POSSIBLE PROLIDASE

(Bifidobacterium
longum) 		PF01979
(Amidohydro_1) 		5 LEU A 338
LEU A 291
GLY A 329
VAL A 269
LEU A 257
 None
 1.17A 5uc1A-2p9bA:
undetectable		 5uc1A-2p9bA:
10.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		9 LEU A  32
LEU A  35
GLY A  37
GLN A  39
MET A  73
LEU A  77
ARG A  80
CYH A 112
MET A 115
 1CA  A 247 (-4.0A)
1CA  A 247 ( 4.4A)
None
1CA  A 247 (-3.1A)
1CA  A 247 (-3.6A)
1CA  A 247 ( 3.9A)
1CA  A 247 (-3.8A)
None
1CA  A 247 ( 3.7A)
 0.75A 5uc1A-2q3yA:
24.4		 5uc1A-2q3yA:
58.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		9 LEU A  35
GLY A  37
GLN A  39
TRP A  69
MET A  73
LEU A  77
ARG A  80
CYH A 112
MET A 115
 1CA  A 247 ( 4.4A)
None
1CA  A 247 (-3.1A)
None
1CA  A 247 (-3.6A)
1CA  A 247 ( 3.9A)
1CA  A 247 (-3.8A)
None
1CA  A 247 ( 3.7A)
 0.82A 5uc1A-2q3yA:
24.4		 5uc1A-2q3yA:
58.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5f TRANSCRIPTIONAL
REGULATOR, PUTATIVE

(Pseudomonas
syringae group
genomosp. 3) 		PF04198
(Sugar-bind) 		5 LEU A 175
GLY A 147
GLY A 148
VAL A 266
LEU A 145
 None
 1.19A 5uc1A-2r5fA:
undetectable		 5uc1A-2r5fA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uyd HEMOPHORE HASA

(Serratia
marcescens) 		PF06438
(HasA) 		5 LEU X 118
LEU X  89
GLY X  70
VAL X  68
LEU X 147
 None
 1.20A 5uc1A-2uydX:
undetectable		 5uc1A-2uydX:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3i PENICILLIN-BINDING
PROTEIN 4

(Haemophilus
influenzae) 		PF02113
(Peptidase_S13) 		5 LEU A 413
LEU A 408
GLY A 407
GLY A 406
LEU A 472
 None
 0.92A 5uc1A-3a3iA:
undetectable		 5uc1A-3a3iA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3i PENICILLIN-BINDING
PROTEIN 4

(Haemophilus
influenzae) 		PF02113
(Peptidase_S13) 		5 LEU A 413
LEU A 408
GLY A 407
GLY A 406
VAL A 466
 None
 0.92A 5uc1A-3a3iA:
undetectable		 5uc1A-3a3iA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1

(Homo sapiens) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		5 LEU A 705
LEU A 708
GLY A 709
GLN A 712
VAL A 713
 None
 0.38A 5uc1A-3dwbA:
undetectable		 5uc1A-3dwbA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19

(Rhodobacter
sphaeroides) 		PF01244
(Peptidase_M19) 		5 LEU A 261
GLY A 302
GLY A  10
LEU A 323
MET A 327
 None
 1.16A 5uc1A-3fdgA:
undetectable		 5uc1A-3fdgA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)

(Oryza sativa) 		PF01450
(IlvC)
PF07991
(IlvN) 		5 LEU A 199
GLY A 137
GLY A 134
GLN A 136
LEU A 298
 NDP  A 601 (-4.7A)
None
NDP  A 601 (-3.7A)
NDP  A 601 (-4.1A)
None
 1.18A 5uc1A-3fr8A:
undetectable		 5uc1A-3fr8A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fss HISTONE CHAPERONE
RTT106

(Saccharomyces
cerevisiae) 		PF08512
(Rtt106) 		5 LEU A  91
LEU A  76
GLY A  78
LEU A 140
MET A 142
 None
 1.13A 5uc1A-3fssA:
undetectable		 5uc1A-3fssA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ial PROLYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		5 LEU A 383
GLY A 314
GLY A 313
LEU A  61
MET A  81
 None
 1.10A 5uc1A-3ialA:
undetectable		 5uc1A-3ialA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju1 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Shewanella
oneidensis) 		PF16113
(ECH_2) 		5 GLY A 168
GLY A 167
MET A 155
LEU A 183
MET A 190
 None
 1.08A 5uc1A-3ju1A:
undetectable		 5uc1A-3ju1A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		5 LEU B 675
LEU B 674
GLY B 680
GLY B 679
LEU B 688
 None
 0.98A 5uc1A-3k70B:
undetectable		 5uc1A-3k70B:
5.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9y 1,25-DIHYDROXYVITAMI
N D(3)
24-HYDROXYLASE,
MITOCHONDRIAL

(Rattus
norvegicus) 		PF00067
(p450) 		5 LEU A  79
GLY A  78
GLY A  77
LEU A 101
MET A  99
 CM5  A 517 ( 4.8A)
None
None
CM5  A 517 ( 4.9A)
None
 1.17A 5uc1A-3k9yA:
undetectable		 5uc1A-3k9yA:
9.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 718
GLY A 722
MET A 759
LEU A 763
ARG A 766
CYH A 798
MET A 801
 WOW  A   1 (-4.2A)
WOW  A   1 ( 4.3A)
WOW  A   1 (-3.7A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-4.2A)
 0.89A 5uc1A-3kbaA:
24.1		 5uc1A-3kbaA:
56.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 718
LEU A 721
GLY A 722
LEU A 763
ARG A 766
CYH A 798
MET A 801
 WOW  A   1 (-4.2A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-4.2A)
 0.67A 5uc1A-3kbaA:
24.1		 5uc1A-3kbaA:
56.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8y PHOSPHOPENTOMUTASE

(Bacillus cereus) 		PF01676
(Metalloenzyme) 		5 LEU A  52
LEU A  70
GLY A  71
GLY A 357
LEU A 316
 None
 0.90A 5uc1A-3m8yA:
undetectable		 5uc1A-3m8yA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naw SECRETED EFFECTOR
PROTEIN

(Escherichia
coli) 		PF00805
(Pentapeptide)
PF13979
(SopA_C)
PF13981
(SopA) 		5 LEU A 686
LEU A 689
GLY A 690
GLY A 691
LEU A 660
 None
 1.01A 5uc1A-3nawA:
undetectable		 5uc1A-3nawA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nv0 NTF2-RELATED EXPORT
PROTEIN

(Caenorhabditis
elegans) 		PF02136
(NTF2) 		5 LEU B  83
GLY B  94
GLY B  93
VAL B 121
LEU B  97
 None
None
NA  B 455 (-3.5A)
None
None
 1.17A 5uc1A-3nv0B:
undetectable		 5uc1A-3nv0B:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pwv MHC CLASS I ANTIGEN

(Bos taurus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 LEU A 129
LEU A 159
GLY A 161
VAL A 164
LEU A 110
 None
 1.12A 5uc1A-3pwvA:
undetectable		 5uc1A-3pwvA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgu LL-DIAMINOPIMELATE
AMINOTRANSFERASE

(Chlamydomonas
reinhardtii) 		PF00155
(Aminotran_1_2) 		5 LEU A 335
LEU A 332
GLY A 331
GLY A 330
VAL A 327
 None
 0.88A 5uc1A-3qguA:
undetectable		 5uc1A-3qguA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qq3 MHC CLASS I ANTIGEN

(Sus scrofa) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 LEU A  81
LEU A  95
GLY A  77
GLY A  75
ARG A 114
 None
 1.16A 5uc1A-3qq3A:
undetectable		 5uc1A-3qq3A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhe NAD-DEPENDENT
BENZALDEHYDE
DEHYDROGENASE

(Legionella
pneumophila) 		PF00903
(Glyoxalase) 		5 LEU A 121
GLN A  72
VAL A  73
LEU A   7
ARG A  47
 None
 1.20A 5uc1A-3rheA:
undetectable		 5uc1A-3rheA:
18.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		10 LEU A  32
LEU A  35
GLY A  36
GLY A  37
GLN A  39
MET A  73
LEU A  77
ARG A  80
CYH A 112
MET A 115
 1CA  A 249 (-3.9A)
1CA  A 249 ( 4.4A)
1CA  A 249 ( 4.0A)
None
1CA  A 249 (-3.0A)
1CA  A 249 (-3.9A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
None
1CA  A 249 (-3.6A)
 0.73A 5uc1A-3ry9A:
24.4		 5uc1A-3ry9A:
70.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		10 LEU A  35
GLY A  36
GLY A  37
GLN A  39
TRP A  69
MET A  73
LEU A  77
ARG A  80
CYH A 112
MET A 115
 1CA  A 249 ( 4.4A)
1CA  A 249 ( 4.0A)
None
1CA  A 249 (-3.0A)
None
1CA  A 249 (-3.9A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
None
1CA  A 249 (-3.6A)
 0.92A 5uc1A-3ry9A:
24.4		 5uc1A-3ry9A:
70.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5o COMPLEMENT COMPONENT
C6

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00084
(Sushi)
PF00090
(TSP_1)
PF01823
(MACPF) 		5 LEU A 302
LEU A 350
GLY A 351
GLY A 352
VAL A 455
 None
 1.11A 5uc1A-3t5oA:
undetectable		 5uc1A-3t5oA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbh O-ACETYL SERINE
SULFHYDRYLASE

(Leishmania
donovani) 		PF00291
(PALP) 		5 LEU A 191
GLY A 188
GLY A 189
VAL A 239
LEU A 218
 None
LLP  A  51 ( 3.4A)
LLP  A  51 ( 3.8A)
None
None
 1.19A 5uc1A-3tbhA:
undetectable		 5uc1A-3tbhA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxo CATALASE-PEROXIDASE

(Synechococcus
elongatus) 		PF00141
(peroxidase) 		5 LEU A 615
LEU A 612
GLY A 611
GLY A 610
VAL A 607
 None
 1.02A 5uc1A-3wxoA:
undetectable		 5uc1A-3wxoA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ade SUCCINYLORNITHINE
TRANSAMINASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		5 GLY A 256
GLY A 257
LEU A 379
ARG A 231
MET A 304
 None
 1.11A 5uc1A-4adeA:
undetectable		 5uc1A-4adeA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SAR1P
SEC23P

(Saccharomyces
cerevisiae) 		PF00025
(Arf)
PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 LEU B  83
LEU B  74
GLY B  75
GLY B  76
CYH A 349
 None
None
GNP  B1190 ( 4.0A)
GNP  B1190 (-3.2A)
None
 1.05A 5uc1A-4bziB:
undetectable		 5uc1A-4bziB:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis) 		PF00141
(peroxidase) 		5 LEU A 634
LEU A 631
GLY A 630
GLY A 629
VAL A 626
 None
 1.09A 5uc1A-4c51A:
undetectable		 5uc1A-4c51A:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvg DIAPHANOUS PROTEIN

(Entamoeba
histolytica) 		PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		5 LEU B 176
LEU B 173
GLY B 172
GLY B 171
VAL B 170
 None
 0.95A 5uc1A-4dvgB:
undetectable		 5uc1A-4dvgB:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eud SUCCINYL-COA:ACETATE
COENZYME A
TRANSFERASE

(Acetobacter
aceti) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 LEU A 246
GLY A 251
VAL A 254
LEU A 398
ARG A 442
 None
 1.13A 5uc1A-4eudA:
undetectable		 5uc1A-4eudA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1h TYROSYL-DNA
PHOSPHODIESTERASE 2

(Danio rerio) 		PF03372
(Exo_endo_phos) 		5 LEU A 254
LEU A 285
GLY A 284
LEU A 274
ARG A 326
 None
 1.07A 5uc1A-4f1hA:
undetectable		 5uc1A-4f1hA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gz2 TYROSYL-DNA
PHOSPHODIESTERASE 2

(Mus musculus) 		PF03372
(Exo_endo_phos) 		5 LEU A 255
LEU A 286
GLY A 285
LEU A 275
ARG A 327
 None
None
None
None
FMT  A 401 ( 4.7A)
 1.19A 5uc1A-4gz2A:
undetectable		 5uc1A-4gz2A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4he8 NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 8

(Thermus
thermophilus) 		no annotation 5 LEU H 264
GLY H 265
GLY H 266
VAL H 186
LEU H 197
 None
 1.15A 5uc1A-4he8H:
undetectable		 5uc1A-4he8H:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		5 LEU M 328
LEU M 325
GLY M 324
GLY M 323
VAL M 320
 None
 0.89A 5uc1A-4heaM:
2.1		 5uc1A-4heaM:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2u ENOYL-COA HYDRATASE

(Rhodobacter
sphaeroides) 		PF16113
(ECH_2) 		5 GLY A 147
GLY A 146
MET A 134
LEU A 162
MET A 169
 None
 1.16A 5uc1A-4j2uA:
undetectable		 5uc1A-4j2uA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlv C-TERMINAL FRAGMENT
OF MEMBRANE PROTEIN
CAPA1, PUTATIVE
UNCHARACTERIZED
PROTEIN CAPB1

(Staphylococcus
aureus) 		PF13614
(AAA_31) 		5 LEU A1100
LEU A1097
GLY A1096
GLY A1125
LEU A1074
 None
 1.20A 5uc1A-4jlvA:
undetectable		 5uc1A-4jlvA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 298
GLY A 168
GLY A 167
LEU A 112
CYH A 134
 None
 1.12A 5uc1A-4l52A:
undetectable		 5uc1A-4l52A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n83 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Streptococcus
sanguinis) 		PF00268
(Ribonuc_red_sm) 		5 LEU A  65
LEU A  62
GLY A  61
GLY A  60
TRP A 123
 None
 1.15A 5uc1A-4n83A:
2.4		 5uc1A-4n83A:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmw PIMELYL-[ACYL-CARRIE
R PROTEIN] METHYL
ESTER ESTERASE

(Salmonella
enterica) 		PF00561
(Abhydrolase_1) 		5 LEU A 183
LEU A 180
GLY A 179
GLY A 178
VAL A 175
 None
 0.76A 5uc1A-4nmwA:
undetectable		 5uc1A-4nmwA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL

(Homo sapiens) 		PF01416
(PseudoU_synth_1) 		5 LEU A 205
GLY A 332
GLY A 330
VAL A 149
CYH A 268
 None
None
None
DLY  A 403 (-4.4A)
None
 1.15A 5uc1A-4nz6A:
undetectable		 5uc1A-4nz6A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozx ALGINATE LYASE

(Klebsiella
pneumoniae) 		PF08787
(Alginate_lyase2) 		5 LEU A 100
GLY A 131
GLY A 132
VAL A 118
ARG A  97
 None
 1.08A 5uc1A-4ozxA:
undetectable		 5uc1A-4ozxA:
17.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 LEU A 563
LEU A 566
GLY A 567
GLY A 568
GLN A 570
VAL A 571
MET A 604
LEU A 608
ARG A 611
CYH A 643
MET A 646
 MOF  A 801 (-3.9A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-3.4A)
None
MOF  A 801 (-2.9A)
None
None
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.2A)
MOF  A 801 ( 3.7A)
MOF  A 801 (-4.4A)
 0.83A 5uc1A-4p6wA:
26.2		 5uc1A-4p6wA:
96.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 LEU A 566
GLY A 567
GLY A 568
GLN A 570
VAL A 571
TRP A 600
MET A 604
LEU A 608
ARG A 611
CYH A 643
MET A 646
 MOF  A 801 ( 4.6A)
MOF  A 801 (-3.4A)
None
MOF  A 801 (-2.9A)
None
None
None
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.2A)
MOF  A 801 ( 3.7A)
MOF  A 801 (-4.4A)
 0.93A 5uc1A-4p6wA:
26.2		 5uc1A-4p6wA:
96.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p79 CLAUDIN-15

(Mus musculus) 		PF00822
(PMP22_Claudin) 		5 LEU A 171
LEU A 174
GLY A 175
GLY A 176
VAL A 179
 None
 0.82A 5uc1A-4p79A:
undetectable		 5uc1A-4p79A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 LEU B 366
LEU B 403
GLY B 124
LEU B 105
MET B 107
 None
 1.11A 5uc1A-4qiwB:
undetectable		 5uc1A-4qiwB:
5.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 769
LEU A 772
GLN A 776
LEU A 814
ARG A 817
CYH A 849
MET A 852
 CV7  A1987 (-4.1A)
CV7  A1987 ( 4.5A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 4.2A)
CV7  A1987 ( 3.7A)
 0.72A 5uc1A-4udbA:
22.4		 5uc1A-4udbA:
47.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 769
LEU A 772
GLY A 774
GLN A 776
LEU A 814
ARG A 817
MET A 852
 CV7  A1987 (-4.1A)
CV7  A1987 ( 4.5A)
None
CV7  A1987 (-3.0A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
 0.71A 5uc1A-4udbA:
22.4		 5uc1A-4udbA:
47.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 772
GLN A 776
TRP A 806
LEU A 814
ARG A 817
CYH A 849
MET A 852
 CV7  A1987 ( 4.5A)
CV7  A1987 (-3.0A)
None
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 4.2A)
CV7  A1987 ( 3.7A)
 0.68A 5uc1A-4udbA:
22.4		 5uc1A-4udbA:
47.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 772
GLY A 774
GLN A 776
TRP A 806
LEU A 814
ARG A 817
MET A 852
 CV7  A1987 ( 4.5A)
None
CV7  A1987 (-3.0A)
None
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
 0.87A 5uc1A-4udbA:
22.4		 5uc1A-4udbA:
47.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xia D-XYLOSE ISOMERASE

(Arthrobacter
sp. NRRL B3728) 		PF01261
(AP_endonuc_2) 		5 LEU A 179
LEU A 192
GLY A 198
GLY A 196
LEU A 205
 None
 1.03A 5uc1A-4xiaA:
undetectable		 5uc1A-4xiaA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0t OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Brucella ovis) 		PF00106
(adh_short) 		5 LEU A  71
LEU A  74
GLY A  75
GLY A  76
LEU A  88
 None
 0.89A 5uc1A-4z0tA:
undetectable		 5uc1A-4z0tA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2o NITRATE TRANSPORTER
1.1

(Arabidopsis
thaliana) 		PF00854
(PTR2) 		5 LEU A 155
LEU A 158
GLY A 159
GLY A 161
VAL A 163
 None
 0.97A 5uc1A-5a2oA:
undetectable		 5uc1A-5a2oA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ay6 FLAGELLAR HOOK
PROTEIN FLGE

(Caulobacter
vibrioides) 		PF07559
(FlaE) 		5 LEU A 392
GLY A 453
GLY A 452
LEU A 349
MET A 351
 None
 0.94A 5uc1A-5ay6A:
undetectable		 5uc1A-5ay6A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6g AGR133CP

(Eremothecium
gossypii) 		PF10345
(Cohesin_load) 		5 LEU A 581
LEU A 584
GLY A 585
GLY A 586
VAL A 590
 None
 1.13A 5uc1A-5c6gA:
2.2		 5uc1A-5c6gA:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fkr ENDO-1,4-BETA-GLUCAN
ASE/XYLOGLUCANASE,
PUTATIVE, GLY74A

(Cellvibrio
japonicus) 		no annotation 5 LEU A  87
LEU A  88
GLY A  73
GLY A  72
LEU A 104
 None
 1.09A 5uc1A-5fkrA:
undetectable		 5uc1A-5fkrA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipf HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE (HGPRT)

(Schistosoma
mansoni) 		PF00156
(Pribosyltran) 		5 LEU A  84
LEU A  81
GLY A  77
VAL A  73
LEU A 137
 None
 1.16A 5uc1A-5ipfA:
undetectable		 5uc1A-5ipfA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwz CELLULOSE-BINDING
FAMILY II

(Streptomyces
sp. SirexAA-E) 		PF02012
(BNR) 		5 LEU A  58
LEU A  59
GLY A  44
GLY A  43
LEU A  75
 None
 1.10A 5uc1A-5jwzA:
undetectable		 5uc1A-5jwzA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei) 		PF00141
(peroxidase) 		5 LEU A 635
GLY A 636
GLY A 637
VAL A 640
LEU A 668
 None
 0.90A 5uc1A-5kqiA:
undetectable		 5uc1A-5kqiA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei) 		PF00141
(peroxidase) 		5 LEU A 641
LEU A 638
GLY A 637
GLY A 636
VAL A 633
 None
 1.05A 5uc1A-5kqiA:
undetectable		 5uc1A-5kqiA:
8.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 7 LEU A 769
LEU A 772
GLY A 774
GLN A 776
LEU A 814
ARG A 817
CYH A 849
 ECV  A1101 (-4.7A)
ECV  A1101 ( 3.9A)
None
ECV  A1101 (-2.9A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.8A)
 0.81A 5uc1A-5mwpA:
22.9		 5uc1A-5mwpA:
43.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 6 LEU A 772
GLN A 776
LEU A 814
ARG A 817
CYH A 849
MET A 852
 ECV  A1101 ( 3.9A)
ECV  A1101 (-2.9A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.8A)
ECV  A1101 (-3.7A)
 1.00A 5uc1A-5mwpA:
22.9		 5uc1A-5mwpA:
43.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 6 LEU A 772
GLN A 776
TRP A 806
LEU A 814
ARG A 817
MET A 852
 ECV  A1101 ( 3.9A)
ECV  A1101 (-2.9A)
None
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
 1.22A 5uc1A-5mwpA:
22.9		 5uc1A-5mwpA:
43.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 6 LEU A 772
GLY A 774
GLN A 776
TRP A 806
LEU A 814
ARG A 817
 ECV  A1101 ( 3.9A)
None
ECV  A1101 (-2.9A)
None
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
 0.80A 5uc1A-5mwpA:
22.9		 5uc1A-5mwpA:
43.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nyw PROTEASOME SUBUNIT

(Yersinia
bercovieri) 		no annotation 6 LEU A 191
GLY A 190
VAL A 189
MET A 179
LEU A 176
MET A 172
 None
 1.42A 5uc1A-5nywA:
undetectable		 5uc1A-5nywA:
19.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		11 LEU A  32
LEU A  35
GLY A  36
GLY A  37
GLN A  39
VAL A  40
MET A  73
LEU A  77
ARG A  80
CYH A 112
MET A 115
 1TA  A 301 (-3.5A)
1TA  A 301 ( 3.6A)
1TA  A 301 (-2.9A)
None
1TA  A 301 (-3.0A)
None
1TA  A 301 (-4.2A)
1TA  A 301 ( 3.4A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.6A)
1TA  A 301 ( 2.8A)
 0.67A 5uc1A-5ufsA:
25.7		 5uc1A-5ufsA:
76.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		11 LEU A  35
GLY A  36
GLY A  37
GLN A  39
VAL A  40
TRP A  69
MET A  73
LEU A  77
ARG A  80
CYH A 112
MET A 115
 1TA  A 301 ( 3.6A)
1TA  A 301 (-2.9A)
None
1TA  A 301 (-3.0A)
None
None
1TA  A 301 (-4.2A)
1TA  A 301 ( 3.4A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.6A)
1TA  A 301 ( 2.8A)
 0.85A 5uc1A-5ufsA:
25.7		 5uc1A-5ufsA:
76.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG

(Saccharomyces
cerevisiae) 		PF10345
(Cohesin_load) 		5 GLY A 411
GLY A 410
GLN A 406
VAL A 405
CYH A 460
 None
 0.93A 5uc1A-5w94A:
2.1		 5uc1A-5w94A:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdu ENVELOPE
GLYCOPROTEIN GP160

(Human
immunodeficiency
virus 1) 		no annotation 5 LEU G 454
GLY G 471
GLY G 472
GLN G 258
VAL G 371
 None
 0.76A 5uc1A-5wduG:
undetectable		 5uc1A-5wduG:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5l ADER

(Acinetobacter
baumannii) 		PF00486
(Trans_reg_C) 		5 LEU A 192
GLY A 234
VAL A 230
LEU A 227
ARG A 215
 LEU  A 192 ( 0.6A)
GLY  A 234 ( 0.0A)
VAL  A 230 ( 0.6A)
LEU  A 227 ( 0.6A)
ARG  A 215 ( 0.6A)
 1.17A 5uc1A-5x5lA:
undetectable		 5uc1A-5x5lA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y29 INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 5 LEU A1730
LEU A1688
GLY A1689
GLY A1690
LEU A1702
 None
 1.19A 5uc1A-5y29A:
undetectable		 5uc1A-5y29A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2a INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 5 LEU A2177
LEU A2135
GLY A2136
GLY A2137
LEU A2149
 None
 1.16A 5uc1A-5y2aA:
undetectable		 5uc1A-5y2aA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo sapiens) 		no annotation 5 LEU A 412
LEU A 409
GLY A 603
GLY A 602
LEU A 424
 None
 0.97A 5uc1A-6fn1A:
undetectable		 5uc1A-6fn1A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b24 PROTEIN (I-DMOI)

(Desulfurococcus
mucosus) 		PF14528
(LAGLIDADG_3) 		3 TRP A 141
MET A 103
ASN A 102
 None
 1.44A 5uc1B-1b24A:
0.0		 5uc1B-1b24A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cqd PROTEIN (PROTEASE
II)

(Zingiber
officinale) 		PF00112
(Peptidase_C1) 		3 TRP A  28
MET A  70
ASN A  71
 None
 1.29A 5uc1B-1cqdA:
0.0		 5uc1B-1cqdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE

(Medicago sativa) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		3 TRP A 148
MET A 149
ASN A 150
 None
 0.93A 5uc1B-1fpqA:
0.0		 5uc1B-1fpqA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gnz GSI-B4 ISOLECTIN

(Griffonia
simplicifolia) 		PF00139
(Lectin_legB) 		3 TRP A  61
MET A 204
ASN A 207
 None
 1.43A 5uc1B-1gnzA:
undetectable		 5uc1B-1gnzA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		3 TRP A 697
MET A 651
ASN A 648
 None
 1.30A 5uc1B-1h7wA:
0.0		 5uc1B-1h7wA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcf BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07679
(I-set) 		3 TRP X 301
MET X 379
ASN X 356
 None
 1.19A 5uc1B-1hcfX:
undetectable		 5uc1B-1hcfX:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwd ERVATAMIN B

(Tabernaemontana
divaricata) 		PF00112
(Peptidase_C1) 		3 TRP A  26
MET A  68
ASN A  69
 None
 1.14A 5uc1B-1iwdA:
0.0		 5uc1B-1iwdA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwl OUTER-MEMBRANE
LIPOPROTEINS CARRIER
PROTEIN

(Escherichia
coli) 		PF03548
(LolA) 		3 TRP A  49
MET A  91
ASN A  87
 None
 1.33A 5uc1B-1iwlA:
undetectable		 5uc1B-1iwlA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p7b INTEGRAL MEMBRANE
CHANNEL AND
CYTOSOLIC DOMAINS

(Burkholderia
pseudomallei) 		PF01007
(IRK) 		3 TRP A 226
MET A 229
ASN A 217
 None
 1.43A 5uc1B-1p7bA:
undetectable		 5uc1B-1p7bA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER

(Escherichia
coli) 		PF07690
(MFS_1) 		3 TRP A 340
MET A 341
ASN A 342
 None
 1.23A 5uc1B-1pw4A:
0.0		 5uc1B-1pw4A:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B

([Haemophilus]
ducreyi) 		PF03372
(Exo_endo_phos) 		3 TRP B  93
MET B 103
ASN B 102
 None
BR  B 512 (-4.4A)
None
 1.38A 5uc1B-1sr4B:
0.0		 5uc1B-1sr4B:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sva SIMIAN VIRUS 40

(Macaca mulatta
polyomavirus 1) 		PF00718
(Polyoma_coat) 		3 TRP 1 110
MET 1 109
ASN 1  99
 None
 1.37A 5uc1B-1sva1:
undetectable		 5uc1B-1sva1:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE

(Thermotoga
maritima) 		PF01008
(IF-2B) 		3 TRP A 219
MET A 216
ASN A 215
 None
 1.20A 5uc1B-1t9kA:
0.1		 5uc1B-1t9kA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwy CARBOXYPEPTIDASE M

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		3 TRP A 241
MET A 229
ASN A 230
 None
 1.41A 5uc1B-1uwyA:
undetectable		 5uc1B-1uwyA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wom SIGMA FACTOR SIGB
REGULATION PROTEIN
RSBQ

(Bacillus
subtilis) 		PF12697
(Abhydrolase_6) 		3 TRP A 155
MET A 147
ASN A 151
 None
PGO  A 612 ( 4.2A)
None
 1.45A 5uc1B-1womA:
undetectable		 5uc1B-1womA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yew PARTICULATE METHANE
MONOOXYGENASE
SUBUNIT C2

(Methylococcus
capsulatus) 		PF04896
(AmoC) 		3 TRP C  89
MET C  90
ASN C  91
 None
 1.37A 5uc1B-1yewC:
undetectable		 5uc1B-1yewC:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)

(Paracoccus
denitrificans) 		PF06433
(Me-amine-dh_H) 		3 TRP H 127
MET H 128
ASN H  69
 None
 1.03A 5uc1B-2bbkH:
undetectable		 5uc1B-2bbkH:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0h MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Mytilus edulis) 		PF00150
(Cellulase) 		3 TRP A 126
MET A 142
ASN A 139
 None
 1.22A 5uc1B-2c0hA:
undetectable		 5uc1B-2c0hA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6a UBIQUITIN-PROTEIN
LIGASE E3 MDM2

(Homo sapiens) 		PF00641
(zf-RanBP) 		3 TRP A 303
MET A 311
ASN A 309
 None
 1.34A 5uc1B-2c6aA:
undetectable		 5uc1B-2c6aA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4c BICARBONATE
TRANSPORTER

(Synechocystis
sp. PCC 6803) 		PF13379
(NMT1_2) 		3 TRP A 120
MET A 122
ASN A 197
 None
 0.83A 5uc1B-2i4cA:
undetectable		 5uc1B-2i4cA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ifg HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF13855
(LRR_8)
PF16920
(TPKR_C2) 		3 TRP A 299
MET A 379
ASN A 356
 None
 1.06A 5uc1B-2ifgA:
undetectable		 5uc1B-2ifgA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ong 4S-LIMONENE SYNTHASE

(Mentha spicata) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 TRP A 487
MET A 543
ASN A 544
 None
 1.49A 5uc1B-2ongA:
2.3		 5uc1B-2ongA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8n LACTOSE PERMEASE

(Escherichia
coli) 		PF01306
(LacY_symp) 		3 TRP A  10
MET A  11
ASN A   8
 None
 0.82A 5uc1B-2v8nA:
undetectable		 5uc1B-2v8nA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		3 TRP A 321
MET A 324
ASN A 254
 None
 1.42A 5uc1B-2vcaA:
undetectable		 5uc1B-2vcaA:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		3 TRP A 423
MET A 388
ASN A 419
 None
 1.31A 5uc1B-3cttA:
undetectable		 5uc1B-3cttA:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3es1 CUPIN 2, CONSERVED
BARREL DOMAIN
PROTEIN

(Novosphingobium
aromaticivorans) 		PF07883
(Cupin_2) 		3 TRP A 136
MET A  85
ASN A 138
 None
 1.40A 5uc1B-3es1A:
undetectable		 5uc1B-3es1A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f1s VITAMIN K-DEPENDENT
PROTEIN Z

(Homo sapiens) 		PF00089
(Trypsin)
PF14670
(FXa_inhibition) 		3 TRP B 354
MET B 211
ASN B 220
 None
 1.37A 5uc1B-3f1sB:
undetectable		 5uc1B-3f1sB:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f75 CATHEPSIN L PROTEASE

(Toxoplasma
gondii) 		PF00112
(Peptidase_C1) 		3 TRP A  32
MET A  76
ASN A  77
 None
 1.29A 5uc1B-3f75A:
undetectable		 5uc1B-3f75A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1

(Schizosaccharomyces
pombe) 		PF04857
(CAF1) 		3 TRP A 105
MET A  34
ASN A  35
 None
 1.35A 5uc1B-3g10A:
undetectable		 5uc1B-3g10A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5c VITAMIN K-DEPENDENT
PROTEIN Z

(Homo sapiens) 		PF00008
(EGF)
PF00089
(Trypsin)
PF14670
(FXa_inhibition) 		3 TRP B 354
MET B 211
ASN B 220
 None
 1.33A 5uc1B-3h5cB:
undetectable		 5uc1B-3h5cB:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hz6 XYLULOKINASE

(Chromobacterium
violaceum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 TRP A 416
MET A 419
ASN A 423
 None
 1.32A 5uc1B-3hz6A:
undetectable		 5uc1B-3hz6A:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qj3 CATHEPSIN L-LIKE
PROTEIN

(Tenebrio
molitor) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		3 TRP A 130
MET A 174
ASN A 175
 None
 1.32A 5uc1B-3qj3A:
undetectable		 5uc1B-3qj3A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		3 TRP A 235
MET A 308
ASN A 306
 SO4  A 701 ( 4.8A)
None
None
 0.51A 5uc1B-3vueA:
undetectable		 5uc1B-3vueA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy8 SERINE PROTEASE

(Paenarthrobacter
nicotinovorans) 		no annotation 3 TRP A  72
MET A  98
ASN A  99
 None
 1.10A 5uc1B-3wy8A:
undetectable		 5uc1B-3wy8A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wz3 TRAM PROTEIN

(Plasmid R64) 		PF11393
(T4BSS_DotI_IcmL) 		3 TRP A 176
MET A  97
ASN A  94
 None
 1.37A 5uc1B-3wz3A:
undetectable		 5uc1B-3wz3A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs6 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Burkholderia
pseudomallei) 		PF00496
(SBP_bac_5) 		3 TRP A  73
MET A 543
ASN A 539
 None
 0.84A 5uc1B-3zs6A:
undetectable		 5uc1B-3zs6A:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apl APICAL MEMBRANE
ANTIGEN 1

(Neospora
caninum) 		PF02430
(AMA-1) 		3 TRP A 347
MET A 155
ASN A 154
 None
 1.19A 5uc1B-4aplA:
undetectable		 5uc1B-4aplA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fas HYDROXYLAMINE
OXIDOREDUCTASE

(Nitrosomonas
europaea) 		PF13447
(Multi-haem_cyto) 		3 TRP A 271
MET A 276
ASN A 461
 None
 1.45A 5uc1B-4fasA:
undetectable		 5uc1B-4fasA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3f SERINE HYDROLASE
CCSP0084

(Cycloclasticus
sp. P1) 		PF12697
(Abhydrolase_6) 		3 TRP A  42
MET A  39
ASN A  37
 None
 1.27A 5uc1B-4i3fA:
undetectable		 5uc1B-4i3fA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3y NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 TRP A 178
MET A 156
ASN A 157
 None
 1.49A 5uc1B-4k3yA:
undetectable		 5uc1B-4k3yA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qh6 CRUZIPAIN

(Trypanosoma
cruzi) 		PF00112
(Peptidase_C1) 		3 TRP A  26
MET A  68
ASN A  69
 None
33L  A 301 (-3.6A)
None
 1.23A 5uc1B-4qh6A:
undetectable		 5uc1B-4qh6A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qwv HIGH-AFFINITY
LEUCINE-SPECIFIC
TRANSPORT SYSTEM
PERIPLASMIC BINDING
PROTEIN, CHEMOTAXIS
PROTEIN CHEY

(Escherichia
coli;
Thermotoga
maritima) 		PF00072
(Response_reg)
PF13458
(Peripla_BP_6) 		3 TRP A 270
MET A  21
ASN A  24
 None
 1.47A 5uc1B-4qwvA:
undetectable		 5uc1B-4qwvA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Pseudarthrobacter
chlorophenolicus) 		PF01547
(SBP_bac_1) 		3 TRP A  64
MET A 362
ASN A 363
 None
 1.44A 5uc1B-4r2fA:
undetectable		 5uc1B-4r2fA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN

(Salmonella
enterica) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1) 		3 TRP A1111
MET A1019
ASN A1018
 None
 1.34A 5uc1B-4u48A:
undetectable		 5uc1B-4u48A:
3.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az4 FLAGELLAR HOOK
SUBUNIT PROTEIN

(Campylobacter
jejuni) 		PF07196
(Flagellin_IN)
PF07559
(FlaE) 		3 TRP A 256
MET A 360
ASN A 350
 None
 1.39A 5uc1B-5az4A:
undetectable		 5uc1B-5az4A:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwd BENZYLSUCCINATE
SYNTHASE ALPHA CHAIN

(Thauera
aromatica) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 TRP A 613
MET A 494
ASN A 490
 FUM  A 901 (-4.5A)
None
None
 1.48A 5uc1B-5bwdA:
undetectable		 5uc1B-5bwdA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9s RRNA BIOGENESIS
PROTEIN RRP5

(Saccharomyces
cerevisiae) 		no annotation 3 TRP B1478
MET B1479
ASN B1480
 None
 0.97A 5uc1B-5c9sB:
undetectable		 5uc1B-5c9sB:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl7 PORIN

(Acinetobacter
baumannii) 		PF03573
(OprD) 		3 TRP A  34
MET A  66
ASN A  64
 C8E  A 510 (-3.7A)
C8E  A 510 ( 4.3A)
None
 1.22A 5uc1B-5dl7A:
undetectable		 5uc1B-5dl7A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqn FRBJ

(Streptomyces
rubellomurinus) 		PF02668
(TauD) 		3 TRP A  15
MET A 177
ASN A 181
 None
 1.24A 5uc1B-5eqnA:
undetectable		 5uc1B-5eqnA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxe EUGENOL OXIDASE

(Rhodococcus
jostii) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		3 TRP A 384
MET A 282
ASN A 279
 None
CIY  A 602 ( 4.0A)
None
 1.15A 5uc1B-5fxeA:
undetectable		 5uc1B-5fxeA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gll GLYCOSIDE HYDROLASE
FAMILY 43

(uncultured
bacterium) 		PF04616
(Glyco_hydro_43) 		3 TRP A 196
MET A  84
ASN A  82
 None
 1.37A 5uc1B-5gllA:
undetectable		 5uc1B-5gllA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL

(Oryctolagus
cuniculus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		3 TRP A 833
MET A 834
ASN A 835
 None
 1.02A 5uc1B-5h53A:
undetectable		 5uc1B-5h53A:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9s ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (MANNOPINE)

(Agrobacterium
fabrum) 		PF13416
(SBP_bac_8) 		3 TRP A 183
MET A 348
ASN A 345
 None
 1.42A 5uc1B-5l9sA:
undetectable		 5uc1B-5l9sA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loa MESO-DIAMINOPIMELATE
D-DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF16654
(DAPDH_C) 		3 TRP A 119
MET A 123
ASN A 127
 NAP  A 401 (-4.2A)
None
None
 1.24A 5uc1B-5loaA:
undetectable		 5uc1B-5loaA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t4y SUSC HOMOLOG

(Bacteroides
thetaiotaomicron) 		no annotation 3 TRP D 488
MET D 487
ASN D 512
 None
 1.45A 5uc1B-5t4yD:
undetectable		 5uc1B-5t4yD:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpc BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		3 TRP A 974
MET A 968
ASN A 966
 None
 1.32A 5uc1B-5tpcA:
undetectable		 5uc1B-5tpcA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwm RRNA BIOGENESIS
PROTEIN RRP5

(Saccharomyces
cerevisiae) 		no annotation 3 TRP A1478
MET A1479
ASN A1480
 None
 0.97A 5uc1B-5wwmA:
undetectable		 5uc1B-5wwmA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		3 TRP C2245
MET C2220
ASN C2217
 None
 1.45A 5uc1B-5y3rC:
undetectable		 5uc1B-5y3rC:
1.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbj TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL, SUBFAMILY
V, MEMBER 4

(Xenopus
tropicalis) 		no annotation 3 TRP A 582
MET A 583
ASN A 584
 None
 1.01A 5uc1B-6bbjA:
undetectable		 5uc1B-6bbjA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8g TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL, SUBFAMILY
V, MEMBER 4

(Xenopus
tropicalis) 		no annotation 3 TRP A 582
MET A 583
ASN A 584
 None
 0.99A 5uc1B-6c8gA:
undetectable		 5uc1B-6c8gA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f74 ALCOHOL OXIDASE

(Thermothelomyces
thermophila) 		no annotation 3 TRP A 493
MET A 541
ASN A 542
 None
None
FAD  A 601 (-4.1A)
 1.24A 5uc1B-6f74A:
undetectable		 5uc1B-6f74A:
17.39