SIMILAR PATTERNS OF AMINO ACIDS FOR 5UBB_A_SAMA301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		4 GLY A 225
ARG A 376
ASP A 229
GLN A 330
 None
 1.36A 5ubbA-1ebvA:
undetectable		 5ubbA-1ebvA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		4 GLY A 227
ARG A 376
ASP A 229
GLN A 241
 None
 1.42A 5ubbA-1ebvA:
undetectable		 5ubbA-1ebvA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		4 GLY A 227
ARG A 376
ASP A 229
GLN A 330
 None
 1.39A 5ubbA-1ebvA:
undetectable		 5ubbA-1ebvA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxs P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B

(Sorghum
bicolor;
Sorghum bicolor) 		PF00450
(Peptidase_S10)
PF00450
(Peptidase_S10) 		4 GLY B 413
ARG B 420
ASP B 359
GLN A 245
 None
 1.49A 5ubbA-1gxsB:
undetectable		 5ubbA-1gxsB:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		4 GLY A 513
ARG A 344
MET A 420
GLN A 440
 None
 1.36A 5ubbA-1l5jA:
undetectable		 5ubbA-1l5jA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Rattus
norvegicus) 		PF01593
(Amino_oxidase) 		4 GLY A 203
ARG A 206
ASP A 132
MET A 131
 None
 1.29A 5ubbA-1o5wA:
undetectable		 5ubbA-1o5wA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulv GLUCODEXTRANASE

(Arthrobacter
globiformis) 		PF00723
(Glyco_hydro_15)
PF09136
(Glucodextran_B)
PF09137
(Glucodextran_N)
PF09985
(Glucodextran_C) 		4 GLY A  65
ARG A 199
ASP A  64
GLN A  74
 None
 1.27A 5ubbA-1ulvA:
undetectable		 5ubbA-1ulvA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA

(Bacillus
subtilis) 		PF00496
(SBP_bac_5) 		4 GLY A 146
ARG A 463
ASP A 145
GLN A 435
 None
 1.50A 5ubbA-1xocA:
undetectable		 5ubbA-1xocA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bma GLUTAMATE
DEHYDROGENASE
(NADP+)

(Plasmodium
falciparum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 GLY A 164
ARG A 205
ASP A 165
GLN A 323
 None
 1.36A 5ubbA-2bmaA:
undetectable		 5ubbA-2bmaA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fem CYTIDYLATE KINASE

(Escherichia
coli) 		PF02224
(Cytidylate_kin) 		4 GLY A  12
ARG A 154
ASP A  11
GLN A 117
 None
 1.45A 5ubbA-2femA:
undetectable		 5ubbA-2femA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vea PHYTOCHROME-LIKE
PROTEIN CPH1

(Synechocystis
sp. PCC 6803) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		4 GLY A 184
ARG A 213
ASP A 185
GLN A 446
 None
 1.39A 5ubbA-2veaA:
undetectable		 5ubbA-2veaA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vun ENAMIDASE

(Eubacterium
barkeri) 		PF01979
(Amidohydro_1) 		4 ARG A 290
ASP A  65
MET A  96
GLN A 191
 None
 1.44A 5ubbA-2vunA:
undetectable		 5ubbA-2vunA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9m POLYMERASE X

(Deinococcus
radiodurans) 		PF14520
(HHH_5)
PF14716
(HHH_8) 		4 GLY A 230
ARG A 125
ASP A 227
GLN A 219
 None
 1.42A 5ubbA-2w9mA:
undetectable		 5ubbA-2w9mA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 4 GLY A 658
ARG A 329
ASP A 652
GLN A 414
 None
None
FAD  A 801 (-3.3A)
FAD  A 801 ( 3.1A)
 1.43A 5ubbA-2yr5A:
undetectable		 5ubbA-2yr5A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3byv RHOPTRY KINASE

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		4 GLY A 448
ARG A 450
ASP A 447
GLN A 547
 None
 1.37A 5ubbA-3byvA:
undetectable		 5ubbA-3byvA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9r THIAMINE
MONOPHOSPHATE KINASE

(Aquifex
aeolicus) 		PF00586
(AIRS) 		4 GLY A 211
ARG A 161
ASP A 215
GLN A 221
 None
 1.03A 5ubbA-3c9rA:
undetectable		 5ubbA-3c9rA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT

(Methanosarcina
barkeri) 		PF03063
(Prismane) 		4 GLY A 506
ARG A 503
MET A 511
GLN A 796
 None
None
None
ACY  A 824 ( 3.2A)
 1.42A 5ubbA-3cf4A:
1.6		 5ubbA-3cf4A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d62 3C-LIKE PROTEINASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF05409
(Peptidase_C30) 		4 GLY A 179
ARG A  40
ASP A 176
GLN A 107
 None
 1.27A 5ubbA-3d62A:
undetectable		 5ubbA-3d62A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dni DEOXYRIBONUCLEASE I

(Bos taurus) 		PF03372
(Exo_endo_phos) 		4 GLY A 100
ARG A  73
ASP A  98
GLN A 156
 None
 1.41A 5ubbA-3dniA:
undetectable		 5ubbA-3dniA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
RESPIRATORY NITRATE
REDUCTASE 1 BETA
CHAIN

(Escherichia
coli;
Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N)
PF13247
(Fer4_11)
PF14711
(Nitr_red_bet_C) 		4 GLY B 150
ARG A1153
ASP A1131
GLN A1242
 None
 1.20A 5ubbA-3egwB:
undetectable		 5ubbA-3egwB:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuu PUTATIVE
METALLOPEPTIDASE

(Chelativorans
sp. BNC1) 		PF07171
(MlrC_C)
PF07364
(DUF1485) 		4 GLY A 117
ARG A 122
ASP A 114
GLN A 471
 None
 1.47A 5ubbA-3iuuA:
2.5		 5ubbA-3iuuA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyf 2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
BIFUNCTIONAL
PERIPLASMIC PROTEIN

(Klebsiella
pneumoniae) 		PF00149
(Metallophos) 		4 GLY A 241
ASP A  16
MET A 275
GLN A  64
 None
MN  A 340 (-3.2A)
None
GOL  A 350 (-3.1A)
 1.26A 5ubbA-3jyfA:
undetectable		 5ubbA-3jyfA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		4 GLY B 510
ARG B 822
ASP B 513
GLN B 520
 None
 1.30A 5ubbA-3k70B:
3.7		 5ubbA-3k70B:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml0 PENICILLIN G
ACYLASE, ALPHA
SUBUNIT
PENICILLIN G
ACYLASE, BETA
SUBUNIT

(Alcaligenes
faecalis;
Alcaligenes
faecalis) 		PF01804
(Penicil_amidase)
PF01804
(Penicil_amidase) 		4 GLY A  50
ARG A  45
ASP A  68
GLN B 111
 None
 1.36A 5ubbA-3ml0A:
undetectable		 5ubbA-3ml0A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om5 LEVANSUCRASE

(Bacillus
megaterium) 		PF02435
(Glyco_hydro_68) 		4 GLY A 294
ARG A 290
ASP A  49
GLN A  56
 None
 1.38A 5ubbA-3om5A:
undetectable		 5ubbA-3om5A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxb PUTATIVE XYLOSE
ISOMERASE

(Rhodospirillum
rubrum) 		PF01261
(AP_endonuc_2) 		4 GLY A 196
ARG A 235
ASP A 194
GLN A  34
 None
None
FE  A 301 ( 3.2A)
None
 1.45A 5ubbA-3qxbA:
undetectable		 5ubbA-3qxbA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u07 UNCHARACTERIZED
PROTEIN VPA0106

(Vibrio
parahaemolyticus) 		PF06742
(DUF1214)
PF06863
(DUF1254) 		4 GLY A 130
ARG A 127
MET A 103
GLN A 135
 None
 1.28A 5ubbA-3u07A:
undetectable		 5ubbA-3u07A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vb9 UNCHARACTERIZED
PROTEIN VPA0735

(Vibrio
parahaemolyticus) 		PF06742
(DUF1214)
PF06863
(DUF1254) 		4 GLY A 351
ARG A 362
ASP A 145
MET A 134
 MG  A 501 ( 4.5A)
None
None
None
 1.25A 5ubbA-3vb9A:
undetectable		 5ubbA-3vb9A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo sapiens) 		PF01593
(Amino_oxidase) 		4 GLY A 194
ARG A 197
ASP A 123
MET A 122
 None
 1.35A 5ubbA-3zyxA:
1.5		 5ubbA-3zyxA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddq DNA GYRASE SUBUNIT A

(Bacillus
subtilis) 		PF00521
(DNA_topoisoIV) 		4 GLY A  41
ASP A  40
MET A 160
GLN A 147
 None
 1.30A 5ubbA-4ddqA:
undetectable		 5ubbA-4ddqA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4du5 PFKB

(Polaromonas sp.
JS666) 		PF00294
(PfkB) 		4 GLY A  82
ARG A  80
ASP A  84
MET A  86
 None
 1.29A 5ubbA-4du5A:
4.0		 5ubbA-4du5A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE

(Escherichia
coli;
Escherichia
virus Qbeta) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
PF03431
(RNA_replicase_B) 		4 GLY A 638
ASP A 639
MET A 636
GLN A 147
 None
 1.47A 5ubbA-4fwtA:
undetectable		 5ubbA-4fwtA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4it1 PUTATIVE GLUCARATE
DEHYDRATASE

(Pseudomonas
fluorescens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A  23
ARG A 423
ASP A 406
GLN A 403
 None
 1.38A 5ubbA-4it1A:
undetectable		 5ubbA-4it1A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k9s GDSL-LIKE
LIPASE/ACYLHYDROLASE
FAMILY PROTEIN

(Neisseria
meningitidis) 		PF00657
(Lipase_GDSL) 		4 GLY A  84
ASP A  85
MET A 117
GLN A  96
 None
 1.20A 5ubbA-4k9sA:
undetectable		 5ubbA-4k9sA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4laq SINGLE HEAVY CHAIN
VARIABLE FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		4 GLY H  32
ARG H  71
ASP H  96
MET H 100
 None
 1.46A 5ubbA-4laqH:
undetectable		 5ubbA-4laqH:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m47 DNA POLYMERASE BETA

(Homo sapiens) 		PF10391
(DNA_pol_lambd_f)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm) 		4 GLY A 179
ARG A 333
ASP A 192
MET A 191
 XG4  A 401 (-3.1A)
None
MG  A 402 (-2.4A)
None
 1.41A 5ubbA-4m47A:
undetectable		 5ubbA-4m47A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		4 GLY A 226
ARG A 377
ASP A 230
GLN A 331
 None
 1.35A 5ubbA-4ph9A:
undetectable		 5ubbA-4ph9A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		4 GLY A 228
ARG A 377
ASP A 230
GLN A 242
 EDO  A 616 ( 4.5A)
None
None
None
 1.43A 5ubbA-4ph9A:
undetectable		 5ubbA-4ph9A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		4 GLY A 228
ARG A 377
ASP A 230
GLN A 331
 EDO  A 616 ( 4.5A)
None
None
None
 1.36A 5ubbA-4ph9A:
undetectable		 5ubbA-4ph9A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE

(Escherichia
coli) 		PF08003
(Methyltransf_9) 		4 GLY A 132
ARG A  90
ASP A 152
GLN A 183
 None
None
None
SO4  A 403 (-4.2A)
 1.47A 5ubbA-4qnxA:
14.3		 5ubbA-4qnxA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN

(Nitratireductor
pacificus) 		PF12838
(Fer4_7)
PF13486
(Dehalogenase) 		4 GLY A 475
ARG A 473
ASP A 476
GLN A 658
 B12  A 803 ( 4.3A)
None
B12  A 803 (-3.3A)
None
 1.11A 5ubbA-4rasA:
undetectable		 5ubbA-4rasA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE

(Psychrobacter
sp. B6) 		PF00155
(Aminotran_1_2) 		4 GLY A 218
ARG A 322
ASP A 224
MET A 221
 None
None
None
NO3  A 404 (-4.8A)
 0.89A 5ubbA-4rkcA:
4.3		 5ubbA-4rkcA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxi TYROCIDINE
SYNTHETASE 3

(Acinetobacter
baumannii) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		4 ARG A 289
ASP A 149
MET A 148
GLN A 394
 None
 0.84A 5ubbA-4zxiA:
2.6		 5ubbA-4zxiA:
10.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e1b N-TERMINAL
XAA-PRO-LYS
N-METHYLTRANSFERASE
1

(Homo sapiens) 		PF05891
(Methyltransf_PK) 		4 GLY A  71
ARG A  74
ASP A  91
GLN A 120
 SAH  A 301 (-3.1A)
SAH  A 301 (-3.9A)
SAH  A 301 (-2.7A)
SAH  A 301 (-3.4A)
 0.21A 5ubbA-5e1bA:
36.2		 5ubbA-5e1bA:
47.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evj ARSENITE
METHYLTRANSFERASE

(Chlamydomonas
reinhardtii) 		PF13847
(Methyltransf_31) 		4 GLY A  93
ARG A  96
ASP A 115
MET A 116
 None
 1.45A 5ubbA-5evjA:
13.3		 5ubbA-5evjA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6c URIC ACID-XANTHINE
PERMEASE

(Aspergillus
nidulans) 		PF00860
(Xan_ur_permease) 		4 GLY A 238
ASP A 241
MET A 452
GLN A 112
 None
 1.27A 5ubbA-5i6cA:
undetectable		 5ubbA-5i6cA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		4 GLY A 225
ARG A 376
ASP A 229
GLN A 330
 None
 1.42A 5ubbA-5ikrA:
undetectable		 5ubbA-5ikrA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		4 GLY A 227
ARG A 376
ASP A 229
GLN A 241
 None
 1.42A 5ubbA-5ikrA:
undetectable		 5ubbA-5ikrA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		4 GLY A 227
ARG A 376
ASP A 229
GLN A 330
 None
 1.43A 5ubbA-5ikrA:
undetectable		 5ubbA-5ikrA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jay 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Paraburkholderia
xenovorans) 		PF00155
(Aminotran_1_2) 		4 GLY A 186
ARG A 309
ASP A 185
MET A 184
 None
 1.42A 5ubbA-5jayA:
undetectable		 5ubbA-5jayA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12

(Homo sapiens) 		PF00443
(UCH) 		4 GLY A 178
ARG A 298
ASP A 198
GLN A 141
 None
 1.44A 5ubbA-5k1cA:
undetectable		 5ubbA-5k1cA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE

(Arabidopsis
thaliana) 		PF03254
(XG_FTase) 		4 GLY A 284
ASP A 285
MET A 279
GLN A 254
 None
 1.33A 5ubbA-5kx6A:
undetectable		 5ubbA-5kx6A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7z MATERNAL PROTEIN
EXUPERANTIA

(Drosophila
melanogaster) 		no annotation 4 GLY A  44
ASP A  49
MET A  48
GLN A 314
 None
 1.40A 5ubbA-5l7zA:
undetectable		 5ubbA-5l7zA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ld5 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Atopobium
vaginae) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 GLY A 257
ARG A 251
ASP A 335
GLN A  35
 None
 1.36A 5ubbA-5ld5A:
4.0		 5ubbA-5ld5A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpc VANADIUM-DEPENDENT
BROMOPEROXIDASE

(Acaryochloris
marina) 		no annotation 4 GLY A 517
ARG A 425
ASP A 598
GLN A 180
 None
 1.14A 5ubbA-5lpcA:
undetectable		 5ubbA-5lpcA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjv CAPSID SUBUNIT VP1
CAPSID SUBUNIT VP3

(Parechovirus A;
Parechovirus A) 		no annotation
no annotation 		4 GLY B 137
ARG B 200
ASP B 239
MET A  56
 None
 1.34A 5ubbA-5mjvB:
undetectable		 5ubbA-5mjvB:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u03 CTP SYNTHASE 1

(Homo sapiens) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		4 GLY A  64
ARG A 479
ASP A  63
GLN A 128
 None
 1.37A 5ubbA-5u03A:
undetectable		 5ubbA-5u03A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		4 GLY A  16
ARG A  27
ASP A  95
GLN A  84
 None
 1.44A 5ubbA-5ufsA:
undetectable		 5ubbA-5ufsA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj4 UNCHARACTERIZED
PROTEIN

(Borrelia
turicatae) 		no annotation 4 GLY A 415
ARG A 419
ASP A 414
MET A 412
 SO4  A 505 (-4.0A)
SO4  A 502 (-3.2A)
None
SO4  A 505 ( 4.8A)
 1.40A 5ubbA-5vj4A:
undetectable		 5ubbA-5vj4A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vnx 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Burkholderia
multivorans) 		PF00155
(Aminotran_1_2) 		4 GLY A 186
ARG A 309
ASP A 185
MET A 184
 None
None
EDO  A 606 (-3.8A)
BEN  A 601 ( 4.5A)
 1.41A 5ubbA-5vnxA:
2.3		 5ubbA-5vnxA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 6
DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens;
Homo sapiens) 		PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N)
PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		4 GLY A 191
ARG A 218
ASP A 192
GLN C2353
 None
 1.50A 5ubbA-5y3rA:
undetectable		 5ubbA-5y3rA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae) 		no annotation 4 GLY A 258
ARG A 256
ASP A 259
GLN A 340
 None
 1.32A 5ubbA-6brdA:
undetectable		 5ubbA-6brdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dub -

(-) 		no annotation 4 GLY A 126
ARG A 129
ASP A 146
MET A 147
 SAH  A 301 (-3.0A)
SAH  A 301 (-3.9A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.5A)
 0.95A 5ubbA-6dubA:
38.7		 5ubbA-6dubA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dub -

(-) 		no annotation 5 GLY A 126
ARG A 129
ASP A 146
MET A 148
GLN A 175
 SAH  A 301 (-3.0A)
SAH  A 301 (-3.9A)
SAH  A 301 (-2.8A)
SAH  A 301 (-4.4A)
SAH  A 301 (-3.5A)
 0.14A 5ubbA-6dubA:
38.7		 5ubbA-6dubA:
undetectable