SIMILAR PATTERNS OF AMINO ACIDS FOR 5UBB_A_SAMA301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a79 TRNA ENDONUCLEASE

(Methanocaldococcus
jannaschii) 		PF01974
(tRNA_int_endo)
PF02778
(tRNA_int_endo_N) 		5 GLY A  26
SER A  31
LEU A  30
VAL A  21
LEU A  45
 None
 1.09A 5ubbA-1a79A:
undetectable		 5ubbA-1a79A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0k PROTEIN (ACONITASE)

(Sus scrofa) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		5 VAL A 202
LEU A  62
VAL A  43
HIS A  46
LEU A  47
 None
 1.30A 5ubbA-1b0kA:
undetectable		 5ubbA-1b0kA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bb9 AMPHIPHYSIN 2

(Rattus
norvegicus) 		PF14604
(SH3_9) 		5 MET A  23
GLY A  66
LEU A  40
VAL A  48
LEU A  42
 None
 1.05A 5ubbA-1bb9A:
undetectable		 5ubbA-1bb9A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bpl ALPHA-1,4-GLUCAN-4-G
LUCANOHYDROLASE

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase) 		5 SER A  29
LEU A  32
GLN A   9
TRP A  41
VAL A  40
 None
 1.17A 5ubbA-1bplA:
undetectable		 5ubbA-1bplA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fzy UBIQUITIN-CONJUGATIN
G ENZYME E2-24 KDA

(Saccharomyces
cerevisiae) 		PF00179
(UQ_con) 		5 GLY A  37
VAL A  27
LEU A 106
VAL A  54
LEU A 109
 None
 1.20A 5ubbA-1fzyA:
undetectable		 5ubbA-1fzyA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8p MAGNESIUM-CHELATASE
38 KDA SUBUNIT

(Rhodobacter
capsulatus) 		PF01078
(Mg_chelatase) 		5 SER A 297
LEU A 295
VAL A 310
HIS A 314
LEU A 315
 None
 1.25A 5ubbA-1g8pA:
undetectable		 5ubbA-1g8pA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jke D-TYR-TRNATYR
DEACYLASE

(Escherichia
coli) 		PF02580
(Tyr_Deacylase) 		5 GLY A 123
SER A  12
LEU A  74
VAL A  76
LEU A  28
 None
 1.26A 5ubbA-1jkeA:
undetectable		 5ubbA-1jkeA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kps RAN-GTPASE
ACTIVATING PROTEIN 1

(Mus musculus) 		PF07834
(RanGAP1_C) 		5 MET B 500
LEU B 582
GLN B 550
VAL B 548
LEU B 586
 None
 1.26A 5ubbA-1kpsB:
undetectable		 5ubbA-1kpsB:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mv0 MYC
BOX-DEPENDENT-INTERA
CTING PROTEIN 1

(Homo sapiens) 		PF14604
(SH3_9) 		5 MET B 411
GLY B 454
LEU B 428
VAL B 436
LEU B 430
 None
 1.27A 5ubbA-1mv0B:
undetectable		 5ubbA-1mv0B:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mv3 MYC BOX DEPENDENT
INTERACTING PROTEIN
1

(Homo sapiens) 		PF14604
(SH3_9) 		5 MET A 411
GLY A 454
LEU A 428
VAL A 436
LEU A 430
 None
 1.20A 5ubbA-1mv3A:
undetectable		 5ubbA-1mv3A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p90 HYPOTHETICAL PROTEIN

(Azotobacter
vinelandii) 		PF02579
(Nitro_FeMo-Co) 		5 VAL A 101
LEU A 205
VAL A 168
HIS A 188
LEU A 190
 None
 1.21A 5ubbA-1p90A:
undetectable		 5ubbA-1p90A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5m SIR4-INTERACTING
PROTEIN SIF2

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		5 GLY A 176
LEU A 226
GLN A 222
VAL A 223
HIS A 208
 None
 1.27A 5ubbA-1r5mA:
undetectable		 5ubbA-1r5mA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urj MAJOR DNA-BINDING
PROTEIN

(Human
alphaherpesvirus
1) 		PF00747
(Viral_DNA_bp) 		5 GLY A 448
LEU A 115
VAL A 511
HIS A 512
LEU A 501
 None
None
None
ZN  A2131 (-2.8A)
None
 1.24A 5ubbA-1urjA:
undetectable		 5ubbA-1urjA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6z HYPOTHETICAL PROTEIN
TTHA0657

(Thermus
thermophilus) 		PF04452
(Methyltrans_RNA) 		5 GLY A  96
VAL A 136
LEU A 219
VAL A  73
LEU A 178
 None
 1.16A 5ubbA-1v6zA:
undetectable		 5ubbA-1v6zA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjs ALPHA-AMYLASE

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 SER A  29
LEU A  32
GLN A   9
TRP A  41
VAL A  40
 None
 1.13A 5ubbA-1vjsA:
undetectable		 5ubbA-1vjsA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wgv KIAA1068 PROTEIN

(Homo sapiens) 		PF04969
(CS) 		5 SER A  53
LEU A  74
GLN A  26
TRP A 104
HIS A  76
 None
 1.20A 5ubbA-1wgvA:
undetectable		 5ubbA-1wgvA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0a MALATE/L-LACTATE
DEHYDROGENASE FAMILY
PROTEIN

(Thermus
thermophilus) 		PF02615
(Ldh_2) 		5 GLY A  83
VAL A 259
SER A  64
GLN A 257
VAL A  61
 None
 1.01A 5ubbA-1x0aA:
undetectable		 5ubbA-1x0aA:
22.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xtp LMAJ004091AAA

(Leishmania
major) 		PF05891
(Methyltransf_PK) 		5 GLY A 101
SER A 148
GLN A 165
TRP A 166
LEU A 171
 SAI  A 401 (-3.4A)
SAI  A 401 (-4.0A)
SAI  A 401 (-4.6A)
None
None
 0.47A 5ubbA-1xtpA:
32.5		 5ubbA-1xtpA:
31.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		5 VAL A 292
SER A 284
LEU A 283
HIS A 280
LEU A 277
 None
 1.21A 5ubbA-2c4mA:
undetectable		 5ubbA-2c4mA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6r DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY

(Deinococcus
radiodurans) 		PF00210
(Ferritin) 		5 VAL A 206
LEU A  81
GLN A 138
VAL A 136
LEU A  85
 None
 1.22A 5ubbA-2c6rA:
undetectable		 5ubbA-2c6rA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Staphylococcus
aureus) 		PF01425
(Amidase) 		5 MET A 191
GLY A 457
VAL A 431
GLN A 454
LEU A 259
 None
 1.24A 5ubbA-2f2aA:
undetectable		 5ubbA-2f2aA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2in5 HYPOTHETICAL
LIPOPROTEIN YMCC

(Escherichia
coli) 		PF11102
(YjbF) 		5 MET A  37
GLY A  74
LEU A  97
GLN A 178
VAL A 176
 None
 1.01A 5ubbA-2in5A:
undetectable		 5ubbA-2in5A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jng CULLIN-7

(Homo sapiens) 		PF11515
(Cul7) 		5 TYR A  34
LEU A  73
GLN A  56
TRP A  67
HIS A  69
 None
 1.24A 5ubbA-2jngA:
undetectable		 5ubbA-2jngA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pb0 ACETYLORNITHINE/SUCC
INYLDIAMINOPIMELATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00202
(Aminotran_3) 		5 MET A 242
GLY A 233
LEU A 382
HIS A 312
LEU A 340
 None
 1.21A 5ubbA-2pb0A:
3.6		 5ubbA-2pb0A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE

(Synechocystis
sp. PCC 6803) 		PF00293
(NUDIX)
PF01467
(CTP_transf_like) 		5 GLY A   8
VAL A  96
LEU A 109
VAL A 107
LEU A 129
 None
 1.26A 5ubbA-2qjoA:
3.1		 5ubbA-2qjoA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsf DNA REPAIR PROTEIN
RAD4

(Saccharomyces
cerevisiae) 		PF03835
(Rad4)
PF10403
(BHD_1)
PF10405
(BHD_3) 		5 GLY A 268
VAL A 333
SER A 168
VAL A 255
LEU A 252
 None
 1.27A 5ubbA-2qsfA:
undetectable		 5ubbA-2qsfA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rsg COLLAGEN TYPE IV
ALPHA-3-BINDING
PROTEIN

(Homo sapiens) 		PF00169
(PH) 		5 SER A  53
LEU A  52
GLN A 107
HIS A 115
LEU A  71
 None
 0.92A 5ubbA-2rsgA:
undetectable		 5ubbA-2rsgA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3z PUTATIVE DEACETYLASE

(Streptococcus
mutans) 		PF01522
(Polysacc_deac_1) 		5 TYR A  86
LEU A 111
VAL A 134
HIS A 135
LEU A 129
 None
 1.23A 5ubbA-2w3zA:
undetectable		 5ubbA-2w3zA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wl1 PYRIN

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		5 GLY A 668
VAL A 722
SER A 757
VAL A 690
LEU A 682
 None
None
EDO  A1780 ( 4.6A)
None
None
 1.15A 5ubbA-2wl1A:
undetectable		 5ubbA-2wl1A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y5c ADRENODOXIN-LIKE
PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF00111
(Fer2) 		5 GLY A  88
LEU A  39
VAL A  54
HIS A  53
LEU A 104
 None
 1.00A 5ubbA-2y5cA:
undetectable		 5ubbA-2y5cA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg6 PUTRESCINE OXIDASE

(Rhodococcus
erythropolis) 		PF01593
(Amino_oxidase) 		5 SER A  70
LEU A  72
GLN A  59
TRP A  60
VAL A  61
 None
 1.29A 5ubbA-2yg6A:
undetectable		 5ubbA-2yg6A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zau SELENIDE, WATER
DIKINASE

(Aquifex
aeolicus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 GLY A 297
LEU A 168
VAL A 220
HIS A 228
LEU A 225
 None
 1.30A 5ubbA-2zauA:
undetectable		 5ubbA-2zauA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze0 ALPHA-GLUCOSIDASE

(Geobacillus sp.
HTA-462) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 LEU A  40
GLN A  13
TRP A  49
VAL A  48
LEU A  93
 None
 1.24A 5ubbA-2ze0A:
undetectable		 5ubbA-2ze0A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh0 DNAB-LIKE
REPLICATIVE HELICASE

(Bacillus phage
SPP1) 		PF03796
(DnaB_C) 		5 VAL A 198
SER A 290
LEU A 320
HIS A 229
LEU A 231
 None
 1.27A 5ubbA-3bh0A:
2.8		 5ubbA-3bh0A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bib T-CELL
IMMUNOGLOBULIN AND
MUCIN
DOMAIN-CONTAINING
PROTEIN 4

(Mus musculus) 		PF07686
(V-set) 		5 GLY X   8
LEU X 107
GLN X  12
VAL X  14
LEU X  16
 None
 1.10A 5ubbA-3bibX:
undetectable		 5ubbA-3bibX:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4n UNCHARACTERIZED
PROTEIN DR_0571

(Deinococcus
radiodurans) 		PF01266
(DAO) 		5 GLY A 236
LEU A 372
GLN A 242
VAL A 240
LEU A 366
 None
 0.97A 5ubbA-3c4nA:
undetectable		 5ubbA-3c4nA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcp HISTIDINOL-PHOSPHATA
SE

(Listeria
monocytogenes) 		PF02811
(PHP)
PF13263
(PHP_C) 		5 TYR A 237
VAL A 203
SER A 121
LEU A 122
GLN A 156
 None
None
FE  A 310 ( 4.1A)
None
None
 1.16A 5ubbA-3dcpA:
undetectable		 5ubbA-3dcpA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 GLY B 585
LEU B 633
VAL B 582
HIS B 639
LEU B 640
 None
 1.19A 5ubbA-3hkzB:
undetectable		 5ubbA-3hkzB:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4y CATECHOL
1,2-DIOXYGENASE

(Rhodococcus
opacus) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		5 TYR A 162
LEU A 153
GLN A 192
HIS A 222
LEU A 223
 35C  A   1 ( 4.2A)
None
None
FE  A 281 ( 3.3A)
None
 1.12A 5ubbA-3i4yA:
undetectable		 5ubbA-3i4yA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im9 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Staphylococcus
aureus) 		PF00698
(Acyl_transf_1) 		5 GLY A  91
VAL A 111
MET A  86
GLN A  63
HIS A  88
 None
None
None
None
SO4  A 901 (-3.6A)
 1.22A 5ubbA-3im9A:
undetectable		 5ubbA-3im9A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv3 TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2

(Streptococcus
mutans) 		PF01791
(DeoC) 		5 GLY A 273
VAL A 203
LEU A 315
VAL A 274
LEU A 311
 None
None
None
None
EDO  A 338 ( 3.9A)
 1.29A 5ubbA-3iv3A:
undetectable		 5ubbA-3iv3A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jwj HEN1

(Trichormus
variabilis) 		PF08242
(Methyltransf_12) 		5 GLY A 288
LEU A 344
VAL A 362
HIS A 365
LEU A 366
 None
 0.72A 5ubbA-3jwjA:
14.9		 5ubbA-3jwjA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndy ENDOGLUCANASE D

(Clostridium
cellulovorans) 		PF00150
(Cellulase) 		5 VAL A  13
MET A 197
SER A 225
GLN A  17
VAL A  19
 None
 1.17A 5ubbA-3ndyA:
undetectable		 5ubbA-3ndyA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nmb PUTATIVE SUGAR
HYDROLASE

(Bacteroides
ovatus) 		PF06439
(DUF1080) 		5 GLY A  72
VAL A  81
SER A  51
LEU A  52
LEU A  54
 None
None
None
None
EDO  A   7 ( 4.7A)
 0.97A 5ubbA-3nmbA:
undetectable		 5ubbA-3nmbA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyq MALONYL-COA LIGASE

(Streptomyces
coelicolor) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 GLY A  62
VAL A  53
LEU A  34
VAL A  66
LEU A   8
 None
 1.18A 5ubbA-3nyqA:
2.8		 5ubbA-3nyqA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjd HIGH AFFINITY
IMMUNOGLOBULIN GAMMA
FC RECEPTOR I

(Homo sapiens) 		PF00047
(ig)
PF13895
(Ig_2)
PF13927
(Ig_3) 		5 SER A 255
LEU A 278
GLN A 246
VAL A 208
LEU A 202
 None
 1.27A 5ubbA-3rjdA:
undetectable		 5ubbA-3rjdA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swt TAURINE CATABOLISM
DIOXYGENASE, TAUD

(Mycobacterium
marinum) 		PF02668
(TauD) 		5 VAL A  44
SER A  22
LEU A  23
VAL A 245
LEU A  53
 None
 1.10A 5ubbA-3swtA:
undetectable		 5ubbA-3swtA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uai H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 4

(Saccharomyces
cerevisiae) 		PF01472
(PUA)
PF01509
(TruB_N)
PF08068
(DKCLD)
PF16198
(TruB_C_2) 		5 GLY A 184
LEU A 139
GLN A 214
VAL A 127
LEU A 203
 None
 1.25A 5ubbA-3uaiA:
undetectable		 5ubbA-3uaiA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3unv ADMH

(Pantoea
agglomerans) 		PF00221
(Lyase_aromatic) 		5 SER A 500
LEU A 499
GLN A 489
VAL A 491
LEU A 290
 None
 1.30A 5ubbA-3unvA:
undetectable		 5ubbA-3unvA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 TYR A 200
GLY A 188
GLN A 268
VAL A 263
LEU A 259
 None
 1.30A 5ubbA-3zduA:
undetectable		 5ubbA-3zduA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bg7 PUTATIVE
TRANSCRIPTIONAL
COACTIVATOR P15

(Escherichia
virus T5) 		PF02229
(PC4) 		5 GLY A  42
VAL A   5
SER A  17
LEU A  30
LEU A  20
 None
 1.21A 5ubbA-4bg7A:
undetectable		 5ubbA-4bg7A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cg4 PYRIN

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		5 GLY A 668
VAL A 722
SER A 757
VAL A 690
LEU A 682
 None
 1.17A 5ubbA-4cg4A:
undetectable		 5ubbA-4cg4A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE

(Thermotoga
maritima) 		PF13597
(NRDD) 		5 TYR A 124
MET A 356
GLY A 439
VAL A 550
VAL A 497
 None
 1.14A 5ubbA-4conA:
undetectable		 5ubbA-4conA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dag NEUTRALIZING
ANTIBODY DS7 HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 MET H 117
SER H 186
LEU H 187
VAL H 159
HIS H 209
 None
 1.01A 5ubbA-4dagH:
undetectable		 5ubbA-4dagH:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia) 		PF00933
(Glyco_hydro_3) 		5 GLY A 107
SER A 155
LEU A 156
VAL A 106
LEU A  88
 None
 1.30A 5ubbA-4g6cA:
undetectable		 5ubbA-4g6cA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE

(Escherichia
coli) 		PF13649
(Methyltransf_25) 		5 VAL A 173
SER A 237
LEU A 228
VAL A 211
HIS A 214
 None
 0.98A 5ubbA-4gekA:
17.2		 5ubbA-4gekA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glk ABIQ

(Lactococcus
lactis) 		PF13958
(ToxN_toxin) 		5 MET A  92
GLY A  36
VAL A  95
VAL A  35
LEU A 119
 None
None
None
None
GOL  A 202 (-4.6A)
 1.14A 5ubbA-4glkA:
undetectable		 5ubbA-4glkA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN

(Ustilago maydis) 		PF01336
(tRNA_anti-codon)
PF08646
(Rep_fac-A_C)
PF16900
(REPA_OB_2) 		5 MET C 401
VAL C 377
SER C 392
VAL C 317
LEU C 306
 None
 1.29A 5ubbA-4gnxC:
undetectable		 5ubbA-4gnxC:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwn TRNA
(CMO5U34)-METHYLTRAN
SFERASE

(Escherichia
coli) 		PF13649
(Methyltransf_25) 		5 VAL A 173
SER A 237
LEU A 228
VAL A 211
HIS A 214
 None
 0.92A 5ubbA-4iwnA:
17.0		 5ubbA-4iwnA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix1 HYPOTHETICAL PROTEIN

(Rhodococcus
opacus) 		no annotation 5 GLY A 153
VAL A 157
LEU A  94
VAL A 120
LEU A 117
 None
 0.97A 5ubbA-4ix1A:
undetectable		 5ubbA-4ix1A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3o OUTER MEMBRANE USHER
PROTEIN FIMD

(Escherichia
coli) 		PF00577
(Usher)
PF13953
(PapC_C)
PF13954
(PapC_N) 		5 GLY D 779
SER D 790
LEU D 789
VAL D 787
LEU D 753
 None
 1.24A 5ubbA-4j3oD:
undetectable		 5ubbA-4j3oD:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kro CETUXIMAB HEAVY
CHAIN

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY D  10
SER D  19
LEU D  18
VAL D  12
LEU D  85
 None
 1.22A 5ubbA-4kroD:
undetectable		 5ubbA-4kroD:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ky9 BAND 3 ANION
TRANSPORT PROTEIN

(Homo sapiens) 		PF07565
(Band_3_cyto) 		5 GLY A 243
VAL A 113
LEU A 135
VAL A 267
LEU A 157
 None
 1.28A 5ubbA-4ky9A:
undetectable		 5ubbA-4ky9A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mch URIDINE
PHOSPHORYLASE

(Aliivibrio
fischeri) 		PF01048
(PNP_UDP_1) 		5 TYR A 119
GLY A 189
SER A 183
LEU A 185
VAL A  74
 None
 0.95A 5ubbA-4mchA:
undetectable		 5ubbA-4mchA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtp RNA DEPENDENT RNA
POLYMERASE

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5) 		5 GLY A 507
VAL A 672
SER A 501
HIS A 386
LEU A 387
 GLY  A 507 ( 0.0A)
VAL  A 672 ( 0.6A)
SER  A 501 ( 0.0A)
HIS  A 386 ( 1.0A)
LEU  A 387 ( 0.5A)
 1.04A 5ubbA-4mtpA:
undetectable		 5ubbA-4mtpA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3 PROTEIN 1

(Vibrio cholerae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 GLY A 208
VAL A 214
SER A 152
HIS A 205
LEU A 204
 COA  A 401 (-3.3A)
None
None
None
None
 1.24A 5ubbA-4nhdA:
undetectable		 5ubbA-4nhdA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oja SUPEROXIDE DISMUTASE
[CU-ZN]

(Hydra vulgaris) 		PF00080
(Sod_Cu) 		5 VAL A  29
LEU A  36
VAL A 118
HIS A 119
LEU A 143
 None
None
None
CU  A 201 (-3.2A)
None
 1.29A 5ubbA-4ojaA:
undetectable		 5ubbA-4ojaA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra0 TYROSINE-PROTEIN
KINASE RECEPTOR UFO

(Homo sapiens) 		PF13895
(Ig_2)
PF13927
(Ig_3) 		5 VAL C 216
SER C 152
LEU C 151
VAL C 187
HIS C 186
 None
 1.21A 5ubbA-4ra0C:
undetectable		 5ubbA-4ra0C:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rus FISH-EGG LECTIN

(Cyprinus carpio) 		PF06462
(Hyd_WA) 		5 GLY A 179
LEU A 186
VAL A 215
HIS A 214
LEU A 224
 None
 1.18A 5ubbA-4rusA:
undetectable		 5ubbA-4rusA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF13407
(Peripla_BP_4) 		5 GLY A 316
SER A 308
LEU A 309
VAL A 149
LEU A 136
 None
 1.27A 5ubbA-4wzzA:
undetectable		 5ubbA-4wzzA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yd8 PROTEIN PTHB1

(Homo sapiens) 		PF14727
(PHTB1_N) 		5 GLY A  43
LEU A  49
GLN A  80
VAL A  78
LEU A  74
 None
 1.18A 5ubbA-4yd8A:
undetectable		 5ubbA-4yd8A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrq TRANSCOBALAMIN-2
CD320 ANTIGEN

(Homo sapiens;
Homo sapiens) 		PF01122
(Cobalamin_bind)
PF14478
(DUF4430)
PF00057
(Ldl_recept_a) 		5 TYR A 139
VAL A 110
LEU A 188
TRP C 150
VAL A 153
 None
 1.20A 5ubbA-4zrqA:
undetectable		 5ubbA-4zrqA:
19.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e1b N-TERMINAL
XAA-PRO-LYS
N-METHYLTRANSFERASE
1

(Homo sapiens) 		PF05891
(Methyltransf_PK) 		8 MET A  30
GLY A  69
LEU A 119
GLN A 135
TRP A 136
VAL A 137
HIS A 140
LEU A 141
 SAH  A 301 (-4.1A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.9A)
SAH  A 301 (-4.6A)
None
SAH  A 301 ( 4.4A)
SAH  A 301 (-3.8A)
None
 0.33A 5ubbA-5e1bA:
36.2		 5ubbA-5e1bA:
47.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9u GLYCOSYLTRANSFERASE
GTF1

(Streptococcus
gordonii) 		PF00534
(Glycos_transf_1) 		5 TYR A 484
GLY A 428
LEU A 410
GLN A 430
LEU A 420
 None
 1.27A 5ubbA-5e9uA:
2.6		 5ubbA-5e9uA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY H  11
SER H  20
LEU H  19
VAL H  13
LEU H  86
 None
 1.28A 5ubbA-5eorH:
undetectable		 5ubbA-5eorH:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f89 CAP248-2B HEAVY
CHAIN

(Homo sapiens) 		no annotation 5 MET H 108
SER H 177
LEU H 178
VAL H 150
HIS H 200
 None
 1.27A 5ubbA-5f89H:
undetectable		 5ubbA-5f89H:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5frd CARBOXYLESTERASE
(EST-2)

(Archaeoglobus
fulgidus) 		PF12697
(Abhydrolase_6) 		5 VAL A 251
SER A  75
LEU A  76
VAL A  85
LEU A  98
 None
 1.28A 5ubbA-5frdA:
undetectable		 5ubbA-5frdA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B

(Homo sapiens) 		no annotation 5 MET A 495
VAL A 489
SER A 617
LEU A 621
HIS A 660
 None
 1.27A 5ubbA-5hdtA:
undetectable		 5ubbA-5hdtA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it9 RIBOSOMAL PROTEIN
RACK1

(Kluyveromyces
lactis) 		PF01092
(Ribosomal_S6e) 		5 GLY g  37
SER g  61
LEU g  43
GLN g  70
VAL g  69
 None
 1.17A 5ubbA-5it9g:
undetectable		 5ubbA-5it9g:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm6 AMINOPEPTIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF02127
(Peptidase_M18) 		5 VAL A 333
SER A 432
LEU A 436
VAL A 477
LEU A 418
 None
 1.17A 5ubbA-5jm6A:
undetectable		 5ubbA-5jm6A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00171
(Aldedh) 		5 LEU A 198
GLN A  66
VAL A  68
HIS A  71
LEU A 193
 None
 1.29A 5ubbA-5jryA:
3.4		 5ubbA-5jryA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxd TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 8

(Mus musculus) 		PF05527
(DUF758) 		5 VAL A  71
LEU A 185
VAL A  57
HIS A 181
LEU A 182
 None
 1.18A 5ubbA-5jxdA:
undetectable		 5ubbA-5jxdA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvp ZOOCIN A
ENDOPEPTIDASE

(Streptococcus
equi) 		PF01551
(Peptidase_M23) 		5 GLY A 108
VAL A 101
SER A  91
LEU A  90
VAL A  47
 None
 1.29A 5ubbA-5kvpA:
undetectable		 5ubbA-5kvpA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l75 LIPOPOLYSACCHARIDE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
LPTB
FIG000906: PREDICTED
PERMEASE

(Klebsiella
pneumoniae;
Klebsiella
pneumoniae) 		PF00005
(ABC_tran)
PF12399
(BCA_ABC_TP_C)
PF03739
(YjgP_YjgQ) 		5 VAL G  91
SER A 139
LEU A 138
VAL A 146
LEU A 130
 None
 1.17A 5ubbA-5l75G:
undetectable		 5ubbA-5l75G:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj3 PRP46

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 MET J 301
VAL J 295
SER J 322
LEU J 316
VAL J 282
 None
 1.27A 5ubbA-5lj3J:
undetectable		 5ubbA-5lj3J:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m89 SPLICEOSOME WD40 SC

(Chaetomium
thermophilum) 		no annotation 6 TYR A 267
GLY A 258
LEU A 286
GLN A 277
VAL A 264
LEU A 295
 None
 1.33A 5ubbA-5m89A:
undetectable		 5ubbA-5m89A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN

(Azotobacter
vinelandii) 		no annotation 5 TYR E  38
MET E 216
GLY E 191
VAL E 188
VAL E 193
 None
 1.23A 5ubbA-5n6yE:
undetectable		 5ubbA-5n6yE:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opg ENVELOPE
GLYCOPROTEIN GN

(Hantaan
orthohantavirus) 		PF01567
(Hanta_G1) 		5 SER A 354
LEU A 311
GLN A  79
VAL A 337
LEU A 328
 None
 1.24A 5ubbA-5opgA:
undetectable		 5ubbA-5opgA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyn DEHYDRATASE,
ILVD/EDD FAMILY

(Caulobacter
vibrioides) 		no annotation 5 GLY A 485
SER A 505
LEU A 511
VAL A 449
LEU A 514
 None
 1.23A 5ubbA-5oynA:
undetectable		 5ubbA-5oynA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5th9 GS-5745 FAB HEAVY
CHAIN

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY H  10
SER H  19
LEU H  18
VAL H  12
LEU H  85
 None
 1.25A 5ubbA-5th9H:
undetectable		 5ubbA-5th9H:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF04598
(Gasdermin)
PF13416
(SBP_bac_8) 		5 SER A1397
LEU A1399
GLN A1344
VAL A1346
LEU A1355
 None
 1.28A 5ubbA-5tj2A:
undetectable		 5ubbA-5tj2A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x41 COBALT TRANSPORT
PROTEIN CBIM

(Rhodobacter
capsulatus) 		no annotation 5 TYR M 127
GLY M  76
VAL M  84
VAL M  79
LEU M 204
 None
 1.07A 5ubbA-5x41M:
undetectable		 5ubbA-5x41M:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6be3 FAB (F598) HEAVY
CHAIN

(Homo sapiens) 		no annotation 5 MET H 119
SER H 188
LEU H 189
VAL H 161
HIS H 211
 None
 1.27A 5ubbA-6be3H:
undetectable		 5ubbA-6be3H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		no annotation 5 GLY A1508
VAL A1314
SER A1511
LEU A1513
VAL A1496
 None
 1.25A 5ubbA-6bhuA:
undetectable		 5ubbA-6bhuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blb HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVB

(Pseudomonas
aeruginosa) 		no annotation 5 GLY A 160
VAL A 179
SER A  88
HIS A 117
LEU A 119
 None
 1.19A 5ubbA-6blbA:
undetectable		 5ubbA-6blbA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-2,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT BETA-2

(Homo sapiens) 		no annotation 6 SER A  73
LEU A  72
GLN A  65
VAL A 124
HIS A 119
LEU A 118
 None
None
None
None
NAG  A 404 (-3.9A)
None
 1.31A 5ubbA-6d6uA:
undetectable		 5ubbA-6d6uA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dub -

(-) 		no annotation 12 TYR A  76
MET A  86
GLY A 124
VAL A 130
MET A 147
SER A 173
LEU A 174
GLN A 190
TRP A 191
VAL A 192
HIS A 195
LEU A 196
 SAH  A 301 (-3.7A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.9A)
None
SAH  A 301 (-3.5A)
UNX  A 311 (-4.0A)
SAH  A 301 (-4.0A)
SAH  A 301 (-4.2A)
GOL  A 303 ( 4.9A)
UNX  A 316 ( 4.3A)
SAH  A 301 (-3.9A)
None
 0.11A 5ubbA-6dubA:
38.7		 5ubbA-6dubA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dub -

(-) 		no annotation 8 TYR A  76
MET A  86
GLY A 124
VAL A 130
MET A 148
GLN A 190
TRP A 191
HIS A 195
 SAH  A 301 (-3.7A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.9A)
None
SAH  A 301 (-4.4A)
SAH  A 301 (-4.2A)
GOL  A 303 ( 4.9A)
SAH  A 301 (-3.9A)
 1.13A 5ubbA-6dubA:
38.7		 5ubbA-6dubA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et9 ACETYL-COA
ACETYLTRANSFERASE
THIOLASE

(Methanothermococcus
thermolithotrophicus) 		no annotation 5 GLY A 380
LEU A 257
VAL A 376
HIS A 284
LEU A 294
 None
 1.18A 5ubbA-6et9A:
undetectable		 5ubbA-6et9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fa5 PUTATIVE MRNA
SPLICING FACTOR

(Chaetomium
thermophilum) 		no annotation 5 VAL A 404
LEU A 675
GLN A 666
VAL A 664
LEU A 689
 None
 1.21A 5ubbA-6fa5A:
undetectable		 5ubbA-6fa5A:
undetectable