SIMILAR PATTERNS OF AMINO ACIDS FOR 5UAN_B_REAB503_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 PHE A 323
LEU A 474
ILE A 422
PHE A 297
LEU A 296
 None
 1.23A 5uanB-1e1tA:
undetectable		 5uanB-1e1tA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 PHE A 323
LEU A 474
ILE A 476
ILE A 422
LEU A 296
 None
 1.27A 5uanB-1e1tA:
undetectable		 5uanB-1e1tA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6i TRANSCRIPTIONAL
ACTIVATOR GCN5

(Saccharomyces
cerevisiae) 		PF00439
(Bromodomain) 		5 LEU A 343
LEU A 340
ILE A 339
ILE A 336
VAL A 399
 None
 0.73A 5uanB-1e6iA:
undetectable		 5uanB-1e6iA:
13.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1exx RETINOIC ACID
RECEPTOR GAMMA-2

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 PHE A 230
ALA A 234
CYH A 237
LEU A 268
LEU A 271
ILE A 275
PHE A 288
SER A 289
PHE A 304
 961  A 450 (-3.9A)
961  A 450 (-3.1A)
961  A 450 (-3.6A)
961  A 450 ( 4.9A)
961  A 450 (-3.6A)
961  A 450 (-3.5A)
961  A 450 (-4.6A)
961  A 450 (-2.5A)
961  A 450 (-3.6A)
 0.52A 5uanB-1exxA:
37.6		 5uanB-1exxA:
72.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1exx RETINOIC ACID
RECEPTOR GAMMA-2

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 PHE A 230
ALA A 234
ILE A 275
PHE A 288
SER A 289
PHE A 304
LEU A 307
 961  A 450 (-3.9A)
961  A 450 (-3.1A)
961  A 450 (-3.5A)
961  A 450 (-4.6A)
961  A 450 (-2.5A)
961  A 450 (-3.6A)
961  A 450 (-4.8A)
 0.57A 5uanB-1exxA:
37.6		 5uanB-1exxA:
72.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr7 HYPOTHETICAL 37.4
KDA PROTEIN IN
ILEY-GABD INTERGENIC
REGION

(Escherichia
coli) 		PF08943
(CsiD) 		5 PHE A  37
LEU A 121
ILE A 122
PHE A  21
LEU A 284
 None
 1.32A 5uanB-1jr7A:
undetectable		 5uanB-1jr7A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3r CONSERVED PROTEIN
MT0001

(Methanothermobacter
thermautotrophicus) 		PF02598
(Methyltrn_RNA_3) 		5 LEU A  61
ILE A  60
PHE A  56
LEU A  30
VAL A 250
 None
 1.45A 5uanB-1k3rA:
0.0		 5uanB-1k3rA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1orj FLAGELLAR PROTEIN
FLIS

(Aquifex
aeolicus) 		PF02561
(FliS) 		5 ALA A1029
LEU A1113
LEU A1110
ILE A1109
ILE A1106
 None
 1.24A 5uanB-1orjA:
undetectable		 5uanB-1orjA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pa4 PROBABLE
RIBOSOME-BINDING
FACTOR A

(Mycoplasma
pneumoniae) 		PF02033
(RBFA) 		5 PHE A  66
ILE A  14
ILE A  17
PHE A  73
SER A  74
 None
 1.14A 5uanB-1pa4A:
undetectable		 5uanB-1pa4A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgv TROPOMODULIN TMD-1

(Caenorhabditis
elegans) 		no annotation 5 PHE A 326
ILE A 286
ILE A 289
SER A 322
LEU A 309
 None
 1.47A 5uanB-1pgvA:
undetectable		 5uanB-1pgvA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rdu CONSERVED
HYPOTHETICAL PROTEIN

(Thermotoga
maritima) 		PF02579
(Nitro_FeMo-Co) 		5 PHE A  21
ALA A  75
ILE A  44
PHE A  27
VAL A  59
 None
 0.87A 5uanB-1rduA:
undetectable		 5uanB-1rduA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rq1 HYPOTHETICAL 65.0
KDA PROTEIN IN
COX14-COS3
INTERGENIC REGION
PRECURSOR

(Saccharomyces
cerevisiae) 		PF04137
(ERO1) 		5 LEU A 400
ILE A 397
PHE A  78
SER A  76
LEU A 391
 None
 1.25A 5uanB-1rq1A:
0.5		 5uanB-1rq1A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN

(Caulobacter
vibrioides) 		PF00072
(Response_reg)
PF00990
(GGDEF) 		5 CYH A  65
LEU A  51
ILE A  82
SER A  97
VAL A 116
 None
 1.42A 5uanB-1w25A:
undetectable		 5uanB-1w25A:
21.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xap RETINOIC ACID
RECEPTOR BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 PHE A 221
ALA A 225
CYH A 228
LEU A 259
LEU A 262
ILE A 263
ILE A 266
PHE A 279
SER A 280
PHE A 295
VAL A 388
 TTB  A   1 (-4.7A)
TTB  A   1 (-4.0A)
TTB  A   1 ( 3.8A)
TTB  A   1 ( 4.9A)
TTB  A   1 (-3.9A)
TTB  A   1 ( 4.9A)
TTB  A   1 ( 4.0A)
TTB  A   1 (-4.6A)
TTB  A   1 (-3.1A)
TTB  A   1 ( 4.1A)
TTB  A   1 (-4.3A)
 0.54A 5uanB-1xapA:
37.1		 5uanB-1xapA:
73.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xdk RETINOIC ACID
RECEPTOR, BETA

(Mus musculus) 		PF00104
(Hormone_recep) 		12 PHE B 221
ALA B 225
CYH B 228
LEU B 259
LEU B 262
ILE B 263
ILE B 266
PHE B 279
SER B 280
PHE B 295
LEU B 298
VAL B 388
 9CR  B 600 ( 4.7A)
9CR  B 600 (-3.8A)
9CR  B 600 (-3.4A)
None
9CR  B 600 (-3.9A)
9CR  B 600 (-4.0A)
9CR  B 600 ( 3.8A)
9CR  B 600 (-4.5A)
9CR  B 600 (-3.0A)
9CR  B 600 (-3.9A)
9CR  B 600 (-4.7A)
9CR  B 600 ( 4.6A)
 0.43A 5uanB-1xdkB:
38.3		 5uanB-1xdkB:
98.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xdk RETINOIC ACID
RECEPTOR, BETA

(Mus musculus) 		PF00104
(Hormone_recep) 		5 PHE B 221
CYH B 228
LEU B 407
PHE B 279
PHE B 295
 9CR  B 600 ( 4.7A)
9CR  B 600 (-3.4A)
None
9CR  B 600 (-4.5A)
9CR  B 600 (-3.9A)
 1.33A 5uanB-1xdkB:
38.3		 5uanB-1xdkB:
98.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzo HYPOTHETICAL PROTEIN
YPMQ

(Bacillus
subtilis) 		PF02630
(SCO1-SenC) 		5 PHE A 120
LEU A  31
LEU A  28
PHE A  75
LEU A 104
 None
None
CA  A1016 ( 4.5A)
None
None
 1.31A 5uanB-1xzoA:
undetectable		 5uanB-1xzoA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzf LIPASE/ACYLHYDROLASE

(Enterococcus
faecalis) 		PF13472
(Lipase_GDSL_2) 		5 ALA A 135
LEU A 144
LEU A 109
ILE A 108
ILE A 110
 None
 1.25A 5uanB-1yzfA:
undetectable		 5uanB-1yzfA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ckh SENTRIN-SPECIFIC
PROTEASE 1

(Homo sapiens) 		PF02902
(Peptidase_C48) 		5 PHE A 497
LEU A 567
LEU A 563
ILE A 562
VAL A 518
 None
 1.38A 5uanB-2ckhA:
undetectable		 5uanB-2ckhA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Thermus
thermophilus) 		PF00202
(Aminotran_3) 		5 PHE A 221
ILE A 204
ILE A 203
PHE A 140
VAL A 209
 None
 1.30A 5uanB-2e7uA:
undetectable		 5uanB-2e7uA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eh3 TRANSCRIPTIONAL
REGULATOR

(Aquifex
aeolicus) 		PF00440
(TetR_N) 		5 PHE A  65
ALA A 115
LEU A 142
LEU A 139
ILE A 138
 None
 0.94A 5uanB-2eh3A:
undetectable		 5uanB-2eh3A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f51 THIOREDOXIN

(Trichomonas
vaginalis) 		PF00085
(Thioredoxin) 		5 LEU A  80
ILE A 104
ILE A 108
PHE A  57
LEU A  45
 None
 1.03A 5uanB-2f51A:
undetectable		 5uanB-2f51A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fxv XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Bacillus
subtilis) 		PF00156
(Pribosyltran) 		5 PHE A  42
LEU A  26
ILE A 154
ILE A 152
LEU A   4
 None
 1.30A 5uanB-2fxvA:
undetectable		 5uanB-2fxvA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grv LPQW

(Mycolicibacterium
smegmatis) 		PF00496
(SBP_bac_5) 		5 ILE A 141
PHE A 157
SER A 158
PHE A 168
LEU A 122
 None
 1.21A 5uanB-2grvA:
undetectable		 5uanB-2grvA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hmf PROBABLE
ASPARTOKINASE

(Methanocaldococcus
jannaschii) 		PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7) 		5 LEU A 457
LEU A 456
ILE A 451
PHE A 449
VAL A 243
 None
 1.27A 5uanB-2hmfA:
undetectable		 5uanB-2hmfA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oew PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN

(Homo sapiens) 		PF03097
(BRO1) 		5 PHE A  93
ILE A  78
ILE A  75
SER A 121
LEU A  21
 None
 1.14A 5uanB-2oewA:
1.5		 5uanB-2oewA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Polaromonas sp.
JS666) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A 199
LEU A 183
ILE A 194
PHE A 233
LEU A 235
 None
 1.27A 5uanB-2og9A:
undetectable		 5uanB-2og9A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plg TLL0839 PROTEIN

(Synechococcus
elongatus) 		PF10722
(YbjN) 		5 ALA A 119
LEU A 134
ILE A 131
ILE A 135
LEU A  65
 None
 1.07A 5uanB-2plgA:
undetectable		 5uanB-2plgA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgn TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE

(Bacillus
halodurans) 		PF01715
(IPPT) 		5 ALA A  24
ILE A 301
ILE A 298
LEU A 197
VAL A  98
 None
 1.40A 5uanB-2qgnA:
undetectable		 5uanB-2qgnA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ve7 KINETOCHORE PROTEIN
HEC1, KINETOCHORE
PROTEIN SPC25

(Homo sapiens) 		PF03801
(Ndc80_HEC)
PF08234
(Spindle_Spc25) 		5 LEU A 185
LEU A 188
ILE A 189
ILE A 192
LEU A 103
 None
 0.76A 5uanB-2ve7A:
undetectable		 5uanB-2ve7A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wcv L-FUCOSE MUTAROTASE

(Escherichia
coli) 		PF05025
(RbsD_FucU) 		5 PHE A 110
LEU A 134
ILE A  26
ILE A 120
PHE A  33
 None
 1.38A 5uanB-2wcvA:
undetectable		 5uanB-2wcvA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0s RNA POLYMERASE
SUBUNIT 8

(Sulfolobus
shibatae) 		PF16992
(RNA_pol_RpbG) 		5 PHE G  71
LEU G  26
ILE G  28
ILE G  29
PHE G  49
 None
 1.36A 5uanB-2y0sG:
undetectable		 5uanB-2y0sG:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7d 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME

(Candidatus
Cloacimonas
acidaminovorans) 		PF05853
(BKACE) 		5 ALA A 132
LEU A 107
LEU A 129
ILE A 126
LEU A 156
 None
 1.42A 5uanB-2y7dA:
undetectable		 5uanB-2y7dA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhg CELLULOSE-BINDING
PROTEIN

(Saccharophagus
degradans) 		PF07632
(DUF1593) 		5 ALA A 585
PHE A 596
SER A 590
LEU A 543
VAL A 729
 None
 1.26A 5uanB-2yhgA:
undetectable		 5uanB-2yhgA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yrr AMINOTRANSFERASE,
CLASS V

(Thermus
thermophilus) 		PF00266
(Aminotran_5) 		5 LEU A 329
LEU A 289
PHE A 276
PHE A 342
LEU A   4
 None
 1.16A 5uanB-2yrrA:
undetectable		 5uanB-2yrrA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahm OLIGOPEPTIDASE

(Geobacillus sp.
MO-1) 		no annotation 5 PHE A 498
ALA A 417
LEU A 251
ILE A 247
ILE A 244
 None
 1.25A 5uanB-3ahmA:
undetectable		 5uanB-3ahmA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cg3 UPF0100 PROTEIN
PH0151

(Pyrococcus
horikoshii) 		PF13531
(SBP_bac_11) 		5 CYH A 157
LEU A 245
ILE A 117
PHE A 149
SER A 150
 None
 1.24A 5uanB-3cg3A:
undetectable		 5uanB-3cg3A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 379
LEU A 384
ILE A 388
PHE A 299
LEU A 417
 None
 1.28A 5uanB-3d5fA:
25.0		 5uanB-3d5fA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcy XYLAN ESTERASE 1

(Thermoanaerobacterium
saccharolyticum) 		PF05448
(AXE1) 		5 PHE A 207
ALA A 223
ILE A 139
SER A  92
LEU A 248
 None
 1.19A 5uanB-3fcyA:
undetectable		 5uanB-3fcyA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fge PUTATIVE FLAVIN
REDUCTASE WITH SPLIT
BARREL DOMAIN

(Shewanella
frigidimarina) 		PF01613
(Flavin_Reduct) 		5 LEU A  58
ILE A  50
SER A  28
PHE A 151
VAL A 139
 None
 1.18A 5uanB-3fgeA:
undetectable		 5uanB-3fgeA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hr0 COG4

(Homo sapiens) 		PF04437
(RINT1_TIP1) 		5 LEU A 711
LEU A 708
PHE A 696
PHE A 627
VAL A 683
 None
 1.32A 5uanB-3hr0A:
undetectable		 5uanB-3hr0A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i7f ASPARTYL-TRNA
SYNTHETASE

(Entamoeba
histolytica) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 ALA A 400
LEU A 419
LEU A 422
ILE A 423
LEU A 389
 None
 1.13A 5uanB-3i7fA:
undetectable		 5uanB-3i7fA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kto RESPONSE REGULATOR
RECEIVER PROTEIN

(Pseudoalteromonas
atlantica) 		PF00072
(Response_reg) 		5 ALA A  23
LEU A  65
ILE A  61
ILE A  60
SER A  28
 None
 1.23A 5uanB-3ktoA:
undetectable		 5uanB-3ktoA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzy RNA POLYMERASE
SIGMA-H FACTOR

(Fusobacterium
nucleatum) 		PF04542
(Sigma70_r2) 		5 ILE A 188
PHE A 150
SER A 151
PHE A 142
VAL A  48
 None
 1.37A 5uanB-3mzyA:
undetectable		 5uanB-3mzyA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf7 BENZOYL-COA
OXYGENASE COMPONENT
B

(Azoarcus
evansii) 		no annotation 5 PHE A 386
ILE A 251
ILE A 255
PHE A 388
LEU A 288
 None
 1.47A 5uanB-3pf7A:
undetectable		 5uanB-3pf7A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qcw NEUREXIN-1-ALPHA

(Bos taurus) 		PF00008
(EGF)
PF02210
(Laminin_G_2) 		5 LEU A 346
LEU A 415
ILE A 301
PHE A 421
VAL A 394
 None
 1.44A 5uanB-3qcwA:
undetectable		 5uanB-3qcwA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL

(Homo sapiens) 		PF00271
(Helicase_C)
PF12513
(SUV3_C) 		5 ALA A 630
LEU A 616
ILE A 665
ILE A 666
SER A 398
 None
 1.38A 5uanB-3rc3A:
undetectable		 5uanB-3rc3A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rys ADENOSINE DEAMINASE
1

(Paenarthrobacter
aurescens) 		PF00962
(A_deaminase) 		5 LEU A 244
ILE A 221
ILE A 197
PHE A 319
LEU A 213
 None
 1.45A 5uanB-3rysA:
undetectable		 5uanB-3rysA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkt CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		5 PHE A 155
ALA A 282
LEU A 393
SER A 277
VAL A 400
 None
None
None
HEM  A 431 (-3.2A)
None
 1.22A 5uanB-3tktA:
undetectable		 5uanB-3tktA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkt CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		5 PHE A 155
ALA A 282
LEU A 397
LEU A 393
SER A 277
 None
None
None
None
HEM  A 431 (-3.2A)
 1.43A 5uanB-3tktA:
undetectable		 5uanB-3tktA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twk FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE 1

(Arabidopsis
thaliana) 		PF01149
(Fapy_DNA_glyco)
PF06831
(H2TH) 		5 PHE A 110
PHE A  43
SER A  46
PHE A  74
LEU A  62
 None
 1.25A 5uanB-3twkA:
undetectable		 5uanB-3twkA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 2

(Mus musculus) 		PF07528
(DZF) 		5 ALA A 252
LEU A 245
LEU A 248
ILE A 244
ILE A 287
 None
 1.42A 5uanB-4atbA:
undetectable		 5uanB-4atbA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 144
ILE A 153
SER A 150
PHE A 176
VAL A 163
 None
 1.45A 5uanB-4bc6A:
undetectable		 5uanB-4bc6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bej DYNAMIN 1-LIKE
PROTEIN

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		5 PHE A  15
ALA A 693
ILE A 701
ILE A 700
LEU A 304
 None
 1.29A 5uanB-4bejA:
undetectable		 5uanB-4bejA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvg DIAPHANOUS PROTEIN

(Entamoeba
histolytica) 		PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		5 ALA B 305
LEU B 245
PHE B 302
SER B 299
LEU B 226
 None
 1.35A 5uanB-4dvgB:
undetectable		 5uanB-4dvgB:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5i GUANINE
NUCLEOTIDE-EXCHANGE
FACTOR SEC12

(Saccharomyces
cerevisiae) 		no annotation 5 ALA A 281
LEU A 338
ILE A 336
ILE A 290
SER A 271
 None
 1.16A 5uanB-4h5iA:
undetectable		 5uanB-4h5iA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itm TETRAACYLDISACCHARID
E 4'-KINASE

(Aquifex
aeolicus) 		PF02606
(LpxK) 		5 LEU A 306
LEU A 309
ILE A 310
LEU A  58
VAL A 184
 None
 1.31A 5uanB-4itmA:
undetectable		 5uanB-4itmA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ALA A3408
ILE A3235
SER A3477
LEU A3251
VAL A3150
 None
 1.23A 5uanB-4kc5A:
undetectable		 5uanB-4kc5A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf8 NUP188

(Thermothelomyces
thermophila) 		no annotation 5 ALA A1635
LEU A1692
ILE A1658
PHE A1585
LEU A1664
 None
 1.25A 5uanB-4kf8A:
undetectable		 5uanB-4kf8A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mes THIAMINE TRANSPORTER
THIT

(Lactococcus
lactis) 		PF09515
(Thia_YuaJ) 		5 ALA A  95
LEU A 166
LEU A  45
ILE A  42
SER A  91
 None
None
None
P6G  A 220 (-3.9A)
PG4  A 207 (-4.8A)
 1.41A 5uanB-4mesA:
undetectable		 5uanB-4mesA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mes THIAMINE TRANSPORTER
THIT

(Lactococcus
lactis) 		PF09515
(Thia_YuaJ) 		5 ALA A  95
LEU A 166
LEU A  45
ILE A  44
SER A  91
 None
None
None
None
PG4  A 207 (-4.8A)
 1.29A 5uanB-4mesA:
undetectable		 5uanB-4mesA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mjk CRISPR PROTEIN

(Archaeoglobus
fulgidus) 		PF09704
(Cas_Cas5d) 		5 ALA A 138
LEU A  37
LEU A  62
ILE A  59
ILE A  58
 None
 1.44A 5uanB-4mjkA:
undetectable		 5uanB-4mjkA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E

(Vibrio cholerae) 		PF02508
(Rnf-Nqr)
PF03116
(NQR2_RnfD_RnfE) 		5 PHE E 190
ALA E  18
SER E  11
PHE B 392
LEU B 395
 None
 1.46A 5uanB-4p6vE:
undetectable		 5uanB-4p6vE:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8i PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Bacillus
subtilis) 		no annotation 5 ALA A 127
LEU A  62
ILE A 105
ILE A 102
PHE A 137
 None
 1.06A 5uanB-4p8iA:
undetectable		 5uanB-4p8iA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psd CARBOHYDRATE
ESTERASE FAMILY 5

(Trichoderma
reesei) 		PF01083
(Cutinase) 		5 ILE A  58
ILE A  51
PHE A 131
LEU A 230
VAL A 100
 None
 1.44A 5uanB-4psdA:
undetectable		 5uanB-4psdA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4j ABC TRANSPORTER

(Thermotoga
maritima) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 LEU A 159
LEU A 162
ILE A 163
ILE A 166
PHE A 243
 None
 0.70A 5uanB-4q4jA:
undetectable		 5uanB-4q4jA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r16 418AA LONG
HYPOTHETICAL
UDP-N-ACETYL-D-MANNO
SAMINURONIC ACID
DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 PHE A 333
ALA A 292
LEU A 299
ILE A 393
VAL A 341
 None
 1.04A 5uanB-4r16A:
undetectable		 5uanB-4r16A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r70 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB2

(Rhodopseudomonas
palustris) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		5 ALA A 165
LEU A 321
ILE A 317
SER A 171
VAL A 327
 None
 1.44A 5uanB-4r70A:
undetectable		 5uanB-4r70A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvw ZNUD

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ALA A 135
LEU A  42
ILE A  37
ILE A  36
LEU A  53
 None
 1.27A 5uanB-4rvwA:
undetectable		 5uanB-4rvwA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmz EIF5B

(Chaetomium
thermophilum) 		no annotation 5 PHE B 643
LEU B 625
ILE B 630
SER B 609
PHE B 695
 CL  B 905 (-4.3A)
None
None
None
None
 1.41A 5uanB-4tmzB:
undetectable		 5uanB-4tmzB:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wlp NUCLEAR FACTOR
RELATED TO
KAPPA-B-BINDING
PROTEIN
UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5

(Homo sapiens) 		PF01088
(Peptidase_C12)
no annotation 		5 PHE B  93
LEU A 302
ILE A 295
LEU B  70
VAL B  61
 None
 1.15A 5uanB-4wlpB:
undetectable		 5uanB-4wlpB:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgh CITRATE SYNTHASE

(Burkholderia
thailandensis) 		PF00285
(Citrate_synt) 		5 PHE A 126
ALA A 180
LEU A 173
PHE A 129
LEU A 146
 None
 1.38A 5uanB-4xghA:
undetectable		 5uanB-4xghA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj6 VC0179-LIKE PROTEIN

(Escherichia
coli) 		no annotation 5 PHE A  45
ILE A 147
PHE A 100
LEU A 153
VAL A 192
 None
 1.14A 5uanB-4xj6A:
undetectable		 5uanB-4xj6A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yte H(2)-FORMING
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE-RELATE
D PROTEIN MJ0715

(Methanocaldococcus
jannaschii) 		no annotation 5 ALA A 160
LEU A 123
ILE A 112
ILE A 111
LEU A 131
 None
 1.29A 5uanB-4yteA:
undetectable		 5uanB-4yteA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlj CRISPR-ASSOCIATED
ENDONUCLEASE CAS1

(Escherichia
coli) 		no annotation 5 LEU D 261
LEU D 264
ILE D 265
ILE D 268
PHE D 215
 None
 1.21A 5uanB-5dljD:
undetectable		 5uanB-5dljD:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dte MONOSACCHARIDE-TRANS
PORTING ATPASE

(Actinobacillus
succinogenes) 		PF13407
(Peripla_BP_4) 		5 ALA A  50
LEU A  61
ILE A  62
ILE A  31
LEU A  34
 None
 1.28A 5uanB-5dteA:
undetectable		 5uanB-5dteA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7c IMMUNOGLOBULIN
G-BINDING PROTEIN A,
DHR14

(Staphylococcus
aureus;
synthetic
construct) 		PF02216
(B) 		5 LEU A 319
LEU A 316
ILE A 315
ILE A 312
VAL A 289
 None
 1.00A 5uanB-5h7cA:
undetectable		 5uanB-5h7cA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE SOPA

(Salmonella
enterica) 		PF13599
(Pentapeptide_4)
PF13981
(SopA) 		5 PHE A 202
ILE A 223
SER A 251
PHE A 207
LEU A 211
 None
 1.23A 5uanB-5jw7A:
undetectable		 5uanB-5jw7A:
21.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5k13 RETINOIC ACID
RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 PHE A 228
CYH A 235
LEU A 266
LEU A 269
ILE A 270
ILE A 273
PHE A 286
SER A 287
PHE A 302
VAL A 395
 6Q7  A 501 (-3.9A)
6Q7  A 501 ( 3.7A)
6Q7  A 501 (-4.2A)
6Q7  A 501 (-3.7A)
6Q7  A 501 (-4.8A)
6Q7  A 501 ( 3.9A)
6Q7  A 501 (-4.7A)
6Q7  A 501 (-2.9A)
6Q7  A 501 ( 4.3A)
6Q7  A 501 (-3.5A)
 0.64A 5uanB-5k13A:
36.1		 5uanB-5k13A:
65.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5k13 RETINOIC ACID
RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 PHE A 228
ILE A 270
PHE A 286
PHE A 302
LEU A 305
VAL A 395
 6Q7  A 501 (-3.9A)
6Q7  A 501 (-4.8A)
6Q7  A 501 (-4.7A)
6Q7  A 501 ( 4.3A)
6Q7  A 501 ( 4.5A)
6Q7  A 501 (-3.5A)
 0.70A 5uanB-5k13A:
36.1		 5uanB-5k13A:
65.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3x NEGATIVE ELONGATION
FACTOR C/D

(Homo sapiens) 		PF04858
(TH1) 		5 LEU B 313
ILE B 310
PHE B 337
LEU B 336
VAL B 330
 None
 1.34A 5uanB-5l3xB:
undetectable		 5uanB-5l3xB:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oom MITOCHONDRIAL
ASSEMBLY OF
RIBOSOMAL LARGE
SUBUNIT PROTEIN 1

(Homo sapiens) 		PF00276
(Ribosomal_L23) 		5 PHE u 172
LEU u 101
LEU u 100
LEU u 179
VAL u 125
 None
 1.11A 5uanB-5oomu:
undetectable		 5uanB-5oomu:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy4 CHAPERONE YAJL

(Escherichia
coli) 		PF01965
(DJ-1_PfpI) 		5 ALA A 161
LEU A  25
LEU A  24
ILE A 169
VAL A  71
 None
 1.11A 5uanB-5sy4A:
undetectable		 5uanB-5sy4A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj3 ALKALINE PHOSPHATASE
PAFA

(Elizabethkingia
meningoseptica) 		PF01663
(Phosphodiest) 		5 ALA A 520
ILE A 544
ILE A 540
PHE A 500
VAL A  32
 None
 1.27A 5uanB-5tj3A:
undetectable		 5uanB-5tj3A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1

(Gallus gallus) 		PF03493
(BK_channel_a)
PF07885
(Ion_trans_2) 		5 ALA A 566
LEU A 574
ILE A 575
ILE A1009
PHE A 999
 None
 1.18A 5uanB-5u70A:
undetectable		 5uanB-5u70A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbn DNA POLYMERASE
EPSILON SUBUNIT 2

(Homo sapiens) 		PF04042
(DNA_pol_E_B)
PF12213
(Dpoe2NT) 		5 LEU A 345
ILE A 349
ILE A 355
PHE A 319
VAL A 293
 None
 1.30A 5uanB-5vbnA:
undetectable		 5uanB-5vbnA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wix P-47 PROTEIN

(Clostridium
botulinum) 		no annotation 5 LEU A 405
ILE A 404
ILE A 403
PHE A 382
LEU A 220
 None
 1.39A 5uanB-5wixA:
undetectable		 5uanB-5wixA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjq GEM-ASSOCIATED
PROTEIN 2

(Homo sapiens) 		no annotation 5 CYH 2 241
LEU 2 233
LEU 2 237
ILE 2 234
LEU 2 222
 None
 1.45A 5uanB-5xjq2:
undetectable		 5uanB-5xjq2:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjs GEM-ASSOCIATED
PROTEIN 2

(Homo sapiens) 		no annotation 5 CYH 2 241
LEU 2 233
LEU 2 237
ILE 2 234
LEU 2 222
 None
 1.43A 5uanB-5xjs2:
undetectable		 5uanB-5xjs2:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsy SODIUM CHANNEL
PROTEIN

(Electrophorus
electricus) 		PF00520
(Ion_trans)
PF06512
(Na_trans_assoc) 		5 ALA A1108
LEU A1457
LEU A1460
ILE A1461
ILE A1464
 None
 1.01A 5uanB-5xsyA:
undetectable		 5uanB-5xsyA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhq CAPSID PROTEIN VP1
CAPSID PROTEIN VP3

(Enterovirus A) 		no annotation 5 PHE A 130
ALA A 128
ILE C  24
SER C  21
PHE A 228
 None
 1.47A 5uanB-5yhqA:
undetectable		 5uanB-5yhqA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cj7 SERPIN-12

(Manduca sexta) 		no annotation 5 LEU A  34
ILE A  33
PHE A 107
SER A 109
VAL A 280
 None
 1.25A 5uanB-6cj7A:
undetectable		 5uanB-6cj7A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epd PROTEASOME SUBUNIT
BETA TYPE-6

(Rattus
norvegicus) 		no annotation 5 PHE 1  75
ALA 1 113
ILE 1 133
ILE 1 132
VAL 1 144
 None
 1.34A 5uanB-6epd1:
undetectable		 5uanB-6epd1:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu9 RETINOIC ACID
RECEPTOR

(Platynereis
dumerilii) 		no annotation 6 LEU A 394
ILE A 398
PHE A 414
SER A 415
PHE A 430
LEU A 433
 None
 0.81A 5uanB-6eu9A:
32.0		 5uanB-6eu9A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez4 RNA POLYMERASE
II-ASSOCIATED
PROTEIN 3

(Homo sapiens) 		no annotation 5 ALA A 639
LEU A 618
LEU A 615
ILE A 614
ILE A 611
 None
 0.94A 5uanB-6ez4A:
undetectable		 5uanB-6ez4A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k POLYSULPHIDE
REDUCTASE NRFD

(Rhodothermus
marinus) 		no annotation 5 ILE C 105
ILE C 102
SER C 116
PHE C 280
VAL C 314
 None
 1.41A 5uanB-6f0kC:
undetectable		 5uanB-6f0kC:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fg7 INACTIVE LRR
RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE BIR2

(Arabidopsis
thaliana) 		no annotation 5 LEU A 147
ILE A 143
ILE A 167
PHE A 180
VAL A 153
 None
 1.25A 5uanB-6fg7A:
undetectable		 5uanB-6fg7A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fx0 RETINOIC ACID
RECEPTOR GAMMA

(Homo sapiens) 		no annotation 9 PHE A 230
ALA A 234
CYH A 237
LEU A 268
LEU A 271
ILE A 275
PHE A 288
PHE A 304
LEU A 307
 E9T  A 501 (-4.3A)
E9T  A 501 (-3.7A)
E9T  A 501 (-3.6A)
E9T  A 501 (-4.9A)
E9T  A 501 (-3.6A)
E9T  A 501 (-3.8A)
E9T  A 501 (-4.7A)
E9T  A 501 (-4.2A)
None
 0.61A 5uanB-6fx0A:
37.8		 5uanB-6fx0A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fx0 RETINOIC ACID
RECEPTOR GAMMA

(Homo sapiens) 		no annotation 9 PHE A 230
ALA A 234
CYH A 237
LEU A 268
LEU A 271
PHE A 288
SER A 289
PHE A 304
LEU A 307
 E9T  A 501 (-4.3A)
E9T  A 501 (-3.7A)
E9T  A 501 (-3.6A)
E9T  A 501 (-4.9A)
E9T  A 501 (-3.6A)
E9T  A 501 (-4.7A)
E9T  A 501 (-2.6A)
E9T  A 501 (-4.2A)
None
 0.63A 5uanB-6fx0A:
37.8		 5uanB-6fx0A:
13.45