SIMILAR PATTERNS OF AMINO ACIDS FOR 5UAN_A_9CRA503_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1air PECTATE LYASE C

(Dickeya
chrysanthemi)
PF00544
(Pec_lyase_C)
5 ILE A  33
ALA A  36
ALA A  35
ALA A  49
VAL A  82
None
0.96A 5uanA-1airA:
undetectable
5uanA-1airA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqu ISOCITRATE LYASE

(Aspergillus
nidulans)
PF00463
(ICL)
5 ILE A 166
ALA A 192
ALA A 191
LEU A  59
ALA A  56
None
0.96A 5uanA-1dquA:
undetectable
5uanA-1dquA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e19 CARBAMATE KINASE

(Pyrococcus
furiosus)
PF00696
(AA_kinase)
6 ILE A  37
ALA A  34
LEU A  97
ALA A  96
VAL A   5
LEU A 234
None
0.94A 5uanA-1e19A:
undetectable
5uanA-1e19A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE


(Escherichia
coli)
PF00155
(Aminotran_1_2)
5 ILE A 238
ALA A 255
ALA A 256
LEU A 100
ALA A  97
None
0.90A 5uanA-1fc4A:
undetectable
5uanA-1fc4A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fs5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE


(Escherichia
coli)
PF01182
(Glucosamine_iso)
5 ILE A  20
ALA A  17
ALA A  16
LEU A  52
ALA A  51
None
0.94A 5uanA-1fs5A:
undetectable
5uanA-1fs5A:
21.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hg4 ULTRASPIRACLE

(Drosophila
melanogaster)
PF00104
(Hormone_recep)
5 TRP A 318
LEU A 366
VAL A 382
CYH A 472
LEU A 476
None
LPP  A   1 ( 4.4A)
LPP  A   1 (-4.8A)
LPP  A   1 ( 4.2A)
LPP  A   1 (-4.2A)
0.81A 5uanA-1hg4A:
24.3
5uanA-1hg4A:
32.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqj A/G-SPECIFIC ADENINE
GLYCOSYLASE


(Escherichia
coli)
PF00633
(HHH)
PF00730
(HhH-GPD)
5 ALA A  93
ALA A  92
GLN A  94
LEU A  65
ALA A  66
None
0.87A 5uanA-1kqjA:
undetectable
5uanA-1kqjA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN


(Oligotropha
carboxidovorans)
PF00111
(Fer2)
PF01799
(Fer2_2)
5 ILE A 149
ALA A 152
ALA A 153
LEU A  90
ALA A  89
None
0.83A 5uanA-1n60A:
undetectable
5uanA-1n60A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pcg ESTROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
5 ALA A 350
TRP A 383
ARG A 394
VAL A 418
LEU A 525
EST  A   1 ( 3.7A)
None
EST  A   1 (-3.7A)
None
EST  A   1 (-3.6A)
1.00A 5uanA-1pcgA:
25.1
5uanA-1pcgA:
24.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r20 ULTRASPIRACLE
PROTEIN


(Heliothis
virescens)
PF00104
(Hormone_recep)
5 TRP A 286
ARG A 297
LEU A 325
VAL A 341
LEU A 435
None
None
None
EPH  A4000 (-4.9A)
EPH  A4000 ( 4.6A)
0.59A 5uanA-1r20A:
24.2
5uanA-1r20A:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA


(Homo sapiens)
PF00104
(Hormone_recep)
12 ILE A 339
ALA A 342
ALA A 343
GLN A 346
TRP A 376
PHE A 384
ARG A 387
LEU A 397
ALA A 398
VAL A 413
CYH A 503
LEU A 507
MEI  A1001 (-3.8A)
MEI  A1001 (-3.1A)
MEI  A1001 (-3.3A)
None
None
MEI  A1001 (-4.5A)
MEI  A1001 (-3.6A)
MEI  A1001 ( 4.4A)
MEI  A1001 (-3.4A)
MEI  A1001 (-4.1A)
MEI  A1001 (-4.0A)
MEI  A1001 (-4.6A)
0.77A 5uanA-1uhlA:
33.6
5uanA-1uhlA:
66.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6c ALKALINE SERINE
PROTEASE


(Pseudoalteromonas
sp. AS-11)
PF00082
(Peptidase_S8)
PF02225
(PA)
5 ILE A 114
ALA A 113
TRP A 104
VAL A 174
LEU A 130
None
None
None
CA  A 505 (-4.5A)
PMS  A 501 (-4.5A)
1.02A 5uanA-1v6cA:
undetectable
5uanA-1v6cA:
20.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata)
PF00104
(Hormone_recep)
12 ILE A 242
ALA A 245
ALA A 246
GLN A 249
TRP A 279
PHE A 287
ARG A 290
LEU A 300
ALA A 301
VAL A 316
CYH A 406
LEU A 410
9CR  A 201 ( 4.4A)
9CR  A 201 (-3.6A)
9CR  A 201 (-3.6A)
9CR  A 201 (-4.1A)
None
9CR  A 201 (-4.7A)
9CR  A 201 (-2.8A)
9CR  A 201 (-4.4A)
9CR  A 201 (-3.4A)
9CR  A 201 (-4.2A)
9CR  A 201 (-3.6A)
9CR  A 201 ( 4.8A)
0.51A 5uanA-1xiuA:
30.3
5uanA-1xiuA:
62.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA


(Homo sapiens)
PF00104
(Hormone_recep)
12 ILE A 268
ALA A 271
ALA A 272
GLN A 275
TRP A 305
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
LEU A 436
9CR  A 801 (-3.9A)
9CR  A 801 (-3.6A)
9CR  A 801 (-3.5A)
9CR  A 801 (-4.7A)
None
9CR  A 801 (-4.3A)
9CR  A 801 (-2.6A)
9CR  A 801 (-4.1A)
9CR  A 801 (-3.3A)
9CR  A 801 ( 4.3A)
9CR  A 801 ( 3.7A)
9CR  A 801 (-4.7A)
0.52A 5uanA-1xlsA:
33.1
5uanA-1xlsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3


(Homo sapiens)
PF00104
(Hormone_recep)
5 ALA B 197
ALA B 198
LEU B 267
ALA B 266
LEU B 342
None
1.01A 5uanA-1xv9B:
19.9
5uanA-1xv9B:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfm FUMARASE

(Saccharomyces
cerevisiae)
PF00206
(Lyase_1)
PF10415
(FumaraseC_C)
5 ILE A 391
ALA A 176
ALA A 177
GLN A 180
LEU A  70
None
1.00A 5uanA-1yfmA:
undetectable
5uanA-1yfmA:
23.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1z5x ULTRASPIRACLE
PROTEIN (USP) A
HOMOLOGUE OF RXR


(Bemisia tabaci)
PF00104
(Hormone_recep)
5 ILE U 303
ALA U 306
ALA U 307
LEU U 365
ALA U 362
None
0.87A 5uanA-1z5xU:
21.8
5uanA-1z5xU:
53.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z69 COENZYME
F420-DEPENDENT
N(5),N(10)-METHYLENE
TETRAHYDROMETHANOPTE
RIN REDUCTASE


(Methanosarcina
barkeri)
PF00296
(Bac_luciferase)
5 ILE A 258
ALA A 257
PHE A 263
LEU A 266
ALA A 265
None
1.00A 5uanA-1z69A:
undetectable
5uanA-1z69A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zk7 MERCURIC REDUCTASE

(Pseudomonas
aeruginosa)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
6 ALA A 452
ALA A 451
GLN A 453
LEU A 434
ALA A 435
VAL A 356
None
None
GOL  A3003 ( 3.8A)
None
None
None
1.22A 5uanA-1zk7A:
undetectable
5uanA-1zk7A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpn GLYCEROL KINASE

(Thermus
thermophilus)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
5 ALA A  57
ALA A  58
ALA A  29
VAL A 163
LEU A 171
None
0.73A 5uanA-2dpnA:
undetectable
5uanA-2dpnA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv2 RCD1 REQUIRED FOR
CELL
DIFFERENTIATION1
HOMOLOG


(Homo sapiens)
PF04078
(Rcd1)
5 ALA A  85
GLN A  82
LEU A 130
ALA A 129
LEU A  51
None
0.75A 5uanA-2fv2A:
undetectable
5uanA-2fv2A:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gl8 RETINOIC ACID
RECEPTOR RXR-GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
6 TRP A  84
PHE A  92
ARG A  95
ALA A 106
VAL A 121
CYH A 211
None
0.99A 5uanA-2gl8A:
26.5
5uanA-2gl8A:
60.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gl8 RETINOIC ACID
RECEPTOR RXR-GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
6 TRP A  84
PHE A  92
LEU A 105
ALA A 106
VAL A 121
CYH A 211
None
0.95A 5uanA-2gl8A:
26.5
5uanA-2gl8A:
60.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iec UNCHARACTERIZED
PROTEIN CONSERVED IN
ARCHAEA


(Methanopyrus
kandleri)
PF04038
(DHNA)
5 ILE A  49
ALA A  52
ALA A  53
GLN A  56
VAL A  66
None
0.99A 5uanA-2iecA:
undetectable
5uanA-2iecA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji9 OXALYL-COA
DECARBOXYLASE


(Oxalobacter
formigenes)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 ILE A 210
ALA A 207
ALA A 206
LEU A 337
ALA A 336
None
0.99A 5uanA-2ji9A:
undetectable
5uanA-2ji9A:
21.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nxx ULTRASPIRACLE (USP,
NR2B4)


(Tribolium
castaneum)
PF00104
(Hormone_recep)
5 PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
None
0.73A 5uanA-2nxxA:
24.4
5uanA-2nxxA:
42.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6w PUTATIVE
GLYCOSYLTRANSFERASE
(MANNOSYLTRANSFERASE
) INVOLVED IN
GLYCOSYLATING THE
PBCV-1 MAJOR CAPSID
PROTEIN


(Paramecium
bursaria
Chlorella virus
1)
PF05637
(Glyco_transf_34)
5 ILE A  61
ALA A  64
ALA A  65
LEU A   9
VAL A 136
None
0.90A 5uanA-2p6wA:
undetectable
5uanA-2p6wA:
23.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q60 RETINOID X RECEPTOR

(Polyandrocarpa
misakiensis)
PF00104
(Hormone_recep)
6 TRP A 180
PHE A 188
ARG A 191
ALA A 202
VAL A 217
CYH A 307
None
0.77A 5uanA-2q60A:
25.8
5uanA-2q60A:
53.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8w POKEWEED ANTIVIRAL
PROTEIN


(Phytolacca
acinosa)
PF00161
(RIP)
5 ILE A 214
ALA A 217
ARG A 240
LEU A 222
ALA A 221
None
0.95A 5uanA-2q8wA:
undetectable
5uanA-2q8wA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qde MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN


(Aromatoleum
aromaticum)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ILE A  69
ALA A 103
GLN A 102
VAL A 387
LEU A  38
None
0.96A 5uanA-2qdeA:
undetectable
5uanA-2qdeA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vml PHYCOCYANIN ALPHA
CHAIN
PHYCOCYANIN BETA
CHAIN


(Gloeobacter
violaceus)
PF00502
(Phycobilisome)
5 ALA A  40
ALA A  41
ALA A 150
VAL B  31
LEU B  24
None
0.83A 5uanA-2vmlA:
undetectable
5uanA-2vmlA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsx EUKARYOTIC
INITIATION FACTOR 4F
SUBUNIT P150


(Saccharomyces
cerevisiae)
PF02854
(MIF4G)
5 ILE E 652
ALA E 656
LEU E 614
VAL E 673
LEU E 753
None
0.96A 5uanA-2vsxE:
undetectable
5uanA-2vsxE:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xax RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
SUBUNIT ALPHA


(Escherichia
coli)
PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone)
5 ILE A  62
ALA A  66
ALA A  65
LEU A  84
ALA A  81
None
1.02A 5uanA-2xaxA:
undetectable
5uanA-2xaxA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgo XCOGT

(Xanthomonas
campestris)
PF13432
(TPR_16)
PF13844
(Glyco_transf_41)
5 ALA A 549
PHE A 228
LEU A 231
ALA A 230
LEU A 328
None
0.97A 5uanA-2xgoA:
undetectable
5uanA-2xgoA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE


(Thermococcus
kodakarensis)
PF00082
(Peptidase_S8)
PF04151
(PPC)
5 ILE A 368
ALA A 415
ALA A 416
LEU A 388
ALA A 387
None
0.96A 5uanA-3afgA:
undetectable
5uanA-3afgA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ci0 PSEUDOPILIN GSPK

(Escherichia
coli)
PF03934
(T2SSK)
5 ILE K 218
ALA K 221
LEU K 119
ALA K 118
LEU K 271
None
0.95A 5uanA-3ci0K:
undetectable
5uanA-3ci0K:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0q PROTEIN CALG3

(Micromonospora
echinospora)
PF06722
(DUF1205)
5 ILE A 233
ALA A 236
ALA A 237
ALA A 334
LEU A 246
None
0.85A 5uanA-3d0qA:
undetectable
5uanA-3d0qA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dme CONSERVED EXPORTED
PROTEIN


(Bordetella
pertussis)
PF01266
(DAO)
5 ILE A  10
ALA A 205
ALA A 204
LEU A 212
ALA A 209
FAD  A 500 (-4.5A)
FAD  A 500 (-3.6A)
None
FAD  A 500 ( 4.3A)
None
0.99A 5uanA-3dmeA:
undetectable
5uanA-3dmeA:
22.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA


(Homo sapiens)
PF00104
(Hormone_recep)
PF00105
(zf-C4)
12 ILE A 268
ALA A 271
ALA A 272
GLN A 275
TRP A 305
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
LEU A 436
9CR  A7223 (-3.9A)
9CR  A7223 (-3.5A)
9CR  A7223 (-4.2A)
9CR  A7223 (-4.6A)
None
9CR  A7223 (-4.5A)
9CR  A7223 (-3.7A)
9CR  A7223 (-3.8A)
9CR  A7223 ( 4.7A)
9CR  A7223 ( 4.5A)
9CR  A7223 (-3.8A)
9CR  A7223 ( 4.7A)
0.81A 5uanA-3dzuA:
32.9
5uanA-3dzuA:
78.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5k RIBOSOME-INACTIVATIN
G PROTEIN
PD-L1/PD-L2


(Phytolacca
dioica)
PF00161
(RIP)
5 ILE A 214
ALA A 217
ARG A 240
LEU A 222
ALA A 221
None
0.92A 5uanA-3h5kA:
undetectable
5uanA-3h5kA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens)
PF00651
(BTB)
PF07707
(BACK)
5 ILE A  47
ALA A  50
ALA A  51
LEU B  20
ALA B  19
None
0.62A 5uanA-3hveA:
undetectable
5uanA-3hveA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens)
PF00651
(BTB)
PF07707
(BACK)
5 ILE A  47
ALA A  50
LEU B  20
ALA B  19
LEU A  87
None
0.66A 5uanA-3hveA:
undetectable
5uanA-3hveA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens)
PF00651
(BTB)
PF07707
(BACK)
5 ILE B  47
ALA B  50
ALA B  51
LEU A  20
ALA A  19
None
0.68A 5uanA-3hveB:
undetectable
5uanA-3hveB:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens)
PF00651
(BTB)
PF07707
(BACK)
5 ILE B  47
ALA B  50
LEU A  20
ALA A  19
LEU B  87
None
0.87A 5uanA-3hveB:
undetectable
5uanA-3hveB:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic5 PUTATIVE
SACCHAROPINE
DEHYDROGENASE


(Ruegeria
pomeroyi)
PF03435
(Sacchrp_dh_NADP)
5 ILE A  82
ALA A  85
ALA A  86
LEU A  60
ALA A  61
None
0.73A 5uanA-3ic5A:
undetectable
5uanA-3ic5A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jru PROBABLE CYTOSOL
AMINOPEPTIDASE


(Xanthomonas
oryzae)
no annotation 5 ALA B 139
ALA B 138
LEU B   3
ALA B   2
VAL B  21
None
0.93A 5uanA-3jruB:
undetectable
5uanA-3jruB:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k11 PUTATIVE GLYCOSYL
HYDROLASE


(Bacteroides
thetaiotaomicron)
PF07470
(Glyco_hydro_88)
5 ILE A 228
ALA A 232
ALA A 230
GLN A 233
LEU A 164
None
0.92A 5uanA-3k11A:
undetectable
5uanA-3k11A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2


(Homo sapiens)
PF02020
(W2)
PF02847
(MA3)
5 ALA A 111
GLN A 143
LEU A 144
VAL A 162
LEU A 128
None
None
None
MES  A 361 (-3.6A)
None
1.00A 5uanA-3l6aA:
undetectable
5uanA-3l6aA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwg HP0420 HOMOLOGUE

(Helicobacter
felis)
no annotation 5 ILE A  56
ALA A  59
ALA A  60
LEU A  38
ALA A  24
None
0.96A 5uanA-3lwgA:
undetectable
5uanA-3lwgA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0m HIT FAMILY PROTEIN

(Mycolicibacterium
smegmatis)
PF01230
(HIT)
5 ILE A  67
ALA A  70
ALA A  71
LEU A 136
ALA A 135
None
0.64A 5uanA-3o0mA:
undetectable
5uanA-3o0mA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o10 SACSIN

(Homo sapiens)
PF05168
(HEPN)
5 ALA A4487
ALA A4488
LEU A4451
ALA A4447
LEU A4519
None
0.88A 5uanA-3o10A:
undetectable
5uanA-3o10A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oks 4-AMINOBUTYRATE
TRANSAMINASE


(Mycolicibacterium
smegmatis)
PF00202
(Aminotran_3)
5 ILE A 327
ALA A 331
ALA A 330
LEU A 298
ALA A 295
None
1.01A 5uanA-3oksA:
undetectable
5uanA-3oksA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N


(Escherichia
coli)
no annotation 5 ILE N 250
ALA N 249
LEU N 119
ALA N 120
LEU N 306
None
0.89A 5uanA-3rkoN:
undetectable
5uanA-3rkoN:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN


(Escherichia
coli)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF)
5 ALA A 602
ALA A 600
LEU A 622
ALA A 618
VAL A 636
None
0.94A 5uanA-3ttfA:
undetectable
5uanA-3ttfA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uc2 HYPOTHETICAL PROTEIN
WITH
IMMUNOGLOBULIN-LIKE
FOLD


(Pseudomonas
aeruginosa)
PF14467
(DUF4426)
5 ILE A  59
ALA A 103
GLN A 104
PHE A 105
LEU A  88
None
0.93A 5uanA-3uc2A:
undetectable
5uanA-3uc2A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upn PENICILLIN-BINDING
PROTEIN A


(Mycobacterium
tuberculosis)
PF00905
(Transpeptidase)
5 ALA A 231
ALA A 232
LEU A 298
ALA A 297
LEU A 274
None
0.95A 5uanA-3upnA:
undetectable
5uanA-3upnA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxw ADIPONECTIN RECEPTOR
PROTEIN 2


(Homo sapiens)
PF03006
(HlyIII)
5 ILE A 322
ALA A 325
ALA A 326
LEU A 283
ALA A 279
None
0.73A 5uanA-3wxwA:
undetectable
5uanA-3wxwA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zil AAR187CP

(Eremothecium
gossypii)
PF16997
(Wap1)
6 ILE A 359
ALA A 356
TRP A 338
LEU A 397
ALA A 393
LEU A 335
None
1.28A 5uanA-3zilA:
undetectable
5uanA-3zilA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zrg PEXRD2 FAMILY
SECRETED RXLR
EFFECTOR PEPTIDE,
PUTATIVE


(Phytophthora
infestans)
no annotation 6 ILE A  86
ALA A  89
ALA A  90
LEU A  99
ALA A  95
VAL A  73
None
None
None
BR  A1122 ( 4.5A)
None
None
1.40A 5uanA-3zrgA:
undetectable
5uanA-3zrgA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7w URIDYLATE KINASE

(Helicobacter
pylori)
PF00696
(AA_kinase)
5 ILE A  39
ALA A  36
LEU A  94
ALA A  93
VAL A  10
None
0.92A 5uanA-4a7wA:
undetectable
5uanA-4a7wA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au0 EXOGLUCANASE 2

(Trichoderma
reesei)
PF01341
(Glyco_hydro_6)
5 ALA A 280
ALA A 279
GLN A 281
LEU A 336
VAL A 323
None
0.96A 5uanA-4au0A:
undetectable
5uanA-4au0A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1


(Saccharomyces
cerevisiae)
PF16417
(CNOT1_TTP_bind)
PF16418
(CNOT1_HEAT)
PF16419
(CNOT1_HEAT_N)
6 ILE A 741
ALA A 744
ALA A 745
LEU A 714
ALA A 715
VAL A 728
None
1.11A 5uanA-4b8bA:
undetectable
5uanA-4b8bA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ia4 AQUAPORIN

(Spinacia
oleracea)
PF00230
(MIP)
5 ALA A 257
ALA A 258
GLN A 261
LEU A 110
ALA A 111
None
0.91A 5uanA-4ia4A:
undetectable
5uanA-4ia4A:
21.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1


(Homo sapiens)
no annotation 12 ILE D 268
ALA D 271
ALA D 272
GLN D 275
TRP D 305
PHE D 313
ARG D 316
LEU D 326
ALA D 327
VAL D 342
CYH D 432
LEU D 436
None
0.74A 5uanA-4j5xD:
32.3
5uanA-4j5xD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz7 CARBAMATE KINASE

(Giardia
intestinalis)
PF00696
(AA_kinase)
5 ILE A  39
ALA A  36
ALA A  35
ALA A  96
VAL A   7
None
0.89A 5uanA-4jz7A:
undetectable
5uanA-4jz7A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz7 CARBAMATE KINASE

(Giardia
intestinalis)
PF00696
(AA_kinase)
5 ILE A  39
ALA A  36
ALA A  96
VAL A   7
LEU A 235
None
1.00A 5uanA-4jz7A:
undetectable
5uanA-4jz7A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6


(Homo sapiens)
PF00069
(Pkinase)
5 ILE A 503
GLN A 660
LEU A 631
VAL A 493
LEU A 667
None
0.93A 5uanA-4ks8A:
undetectable
5uanA-4ks8A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR


(Verminephrobacter
eiseniae)
PF13458
(Peripla_BP_6)
5 ILE A 191
ALA A 188
ALA A 187
LEU A 215
ALA A 214
None
0.99A 5uanA-4m88A:
undetectable
5uanA-4m88A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mij TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Polaromonas sp.
JS666)
PF03480
(DctP)
5 ILE A 261
ALA A 265
ALA A 264
LEU A 146
ALA A 147
None
1.00A 5uanA-4mijA:
undetectable
5uanA-4mijA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nn1 TRANSCRIPTIONAL
REGULATOR


(Mycobacterium
tuberculosis)
PF00440
(TetR_N)
5 ILE A  12
ALA A  15
ALA A  16
GLN A  19
ALA A  35
None
0.66A 5uanA-4nn1A:
undetectable
5uanA-4nn1A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL


(Homo sapiens)
PF04960
(Glutaminase)
6 ILE A 250
ALA A 376
GLN A 379
ARG A 382
VAL A 484
CYH A 283
None
None
None
None
ONL  A 601 (-3.7A)
None
1.25A 5uanA-4o7dA:
undetectable
5uanA-4o7dA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p47 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Ochrobactrum
anthropi)
PF03480
(DctP)
5 ILE A 260
ALA A 264
ALA A 263
LEU A 144
ALA A 145
None
0.95A 5uanA-4p47A:
undetectable
5uanA-4p47A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdd TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Polaromonas sp.
JS666)
PF03480
(DctP)
5 ALA A 267
ALA A 266
GLN A 268
LEU A 147
ALA A 148
None
0.93A 5uanA-4pddA:
undetectable
5uanA-4pddA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pf6 C4-DICARBOXYLATE-BIN
DING PROTEIN


(Roseobacter
denitrificans)
PF03480
(DctP)
5 ILE A 242
ALA A 267
ALA A 268
LEU A  46
ALA A  45
None
0.99A 5uanA-4pf6A:
undetectable
5uanA-4pf6A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rrj PROBABLE
THREONINE--TRNA
LIGASE 2


(Aeropyrum
pernix)
PF08915
(tRNA-Thr_ED)
5 ILE A  58
ALA A  55
ALA A  54
LEU A  99
ALA A  98
None
0.89A 5uanA-4rrjA:
undetectable
5uanA-4rrjA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqg DNA POLYMERASE

(Geobacillus
stearothermophilus)
PF00476
(DNA_pol_A)
5 ILE A 804
ALA A 801
ALA A 800
GLN A 797
LEU A 862
None
0.96A 5uanA-4uqgA:
undetectable
5uanA-4uqgA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1u LYND

(Lyngbya
aestuarii)
PF02624
(YcaO)
6 ILE A 264
ALA A 261
ALA A 260
LEU A 134
ALA A 133
LEU A 286
None
1.18A 5uanA-4v1uA:
undetectable
5uanA-4v1uA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9n L-ALPHA-GLYCEROPHOSP
HATE OXIDASE


(Mycoplasma
pneumoniae)
PF01266
(DAO)
5 ALA A 209
ALA A 208
LEU A 216
ALA A 213
VAL A 202
FAD  A 401 (-3.6A)
None
None
None
None
0.97A 5uanA-4x9nA:
undetectable
5uanA-4x9nA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xa8 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
NAD-BINDING


(Xanthobacter
autotrophicus)
PF02826
(2-Hacid_dh_C)
5 ILE A 296
ALA A 293
ALA A 292
LEU A  25
ALA A  24
None
0.91A 5uanA-4xa8A:
undetectable
5uanA-4xa8A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ


(Escherichia
coli)
PF00588
(SpoU_methylase)
6 ALA A  53
ALA A  22
LEU A  49
ALA A  50
VAL A  40
LEU A   9
None
1.15A 5uanA-4xboA:
undetectable
5uanA-4xboA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ


(Escherichia
coli)
PF00588
(SpoU_methylase)
6 ILE A  57
ALA A  53
ALA A  22
LEU A  49
ALA A  50
LEU A   9
None
1.46A 5uanA-4xboA:
undetectable
5uanA-4xboA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgj UNCHARACTERIZED
PROTEIN


(Pectobacterium
atrosepticum)
PF07005
(DUF1537)
PF17042
(DUF1357_C)
5 ALA A 214
ALA A 215
LEU A 183
ALA A 184
LEU A 230
None
0.97A 5uanA-4xgjA:
undetectable
5uanA-4xgjA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgj UNCHARACTERIZED
PROTEIN


(Pectobacterium
atrosepticum)
PF07005
(DUF1537)
PF17042
(DUF1357_C)
5 ILE A 211
ALA A 214
ALA A 215
LEU A 183
ALA A 184
None
0.66A 5uanA-4xgjA:
undetectable
5uanA-4xgjA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yk2 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS


(Bartonella
clarridgeiae)
no annotation 5 ILE A 160
ALA A 156
PHE A 103
LEU A 140
ALA A 141
None
0.98A 5uanA-4yk2A:
undetectable
5uanA-4yk2A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrs ESTERASE

(uncultured
bacterium)
PF07859
(Abhydrolase_3)
5 ALA A  97
GLN A 100
ARG A 286
ALA A 282
VAL A 135
None
0.96A 5uanA-4zrsA:
undetectable
5uanA-4zrsA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gt5 PECTATE LYASE

(Paenibacillus
sp. 0602)
no annotation 5 ILE A 117
ALA A 116
ALA A 115
PHE A 132
LEU A  39
None
1.00A 5uanA-5gt5A:
undetectable
5uanA-5gt5A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE


(Vibrio cholerae)
PF01182
(Glucosamine_iso)
5 ILE A  20
ALA A  17
ALA A  16
LEU A  52
ALA A  51
None
0.93A 5uanA-5hj5A:
undetectable
5uanA-5hj5A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iuw ALDEHYDE
DEHYDROGENASE FAMILY
PROTEIN


(Pseudomonas
syringae group
genomosp. 3)
no annotation 5 ILE A 294
ALA A 291
ALA A 290
LEU A 326
ALA A 325
None
1.01A 5uanA-5iuwA:
undetectable
5uanA-5iuwA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m49 AMINOTRANSFERASE
CLASS-III


(Rhizobium
freirei)
PF00202
(Aminotran_3)
5 ILE A 199
ALA A 201
ALA A 202
VAL A 194
LEU A 187
None
0.94A 5uanA-5m49A:
undetectable
5uanA-5m49A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0g PRECORRIN-8X
METHYLMUTASE


(Rhodobacter
capsulatus)
no annotation 6 ILE A  73
ALA A  71
ALA A 130
LEU A  67
ALA A  66
VAL A  80
None
1.25A 5uanA-5n0gA:
undetectable
5uanA-5n0gA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-)
no annotation 5 ILE A 257
ALA A 260
PHE A 541
LEU A 538
ALA A 539
None
0.89A 5uanA-5ohsA:
undetectable
5uanA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN


(Bacillus
anthracis)
PF00496
(SBP_bac_5)
6 ILE A 304
ALA A 305
ALA A 303
GLN A 302
ALA A 484
VAL A 393
None
1.34A 5uanA-5u4oA:
undetectable
5uanA-5u4oA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ui2 ORANGE
CAROTENOID-BINDING
PROTEIN


(Arthrospira
maxima)
PF02136
(NTF2)
PF09150
(Carot_N)
5 ILE A 305
ALA A 304
LEU A 225
ALA A 224
VAL A 275
EQ3  A 403 ( 3.8A)
None
None
None
EQ3  A 403 (-4.7A)
0.95A 5uanA-5ui2A:
undetectable
5uanA-5ui2A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi RIBOSOMAL PROTEIN
S19E, PUTATIVE


(Trichomonas
vaginalis)
PF01090
(Ribosomal_S19e)
5 ILE T  68
ALA T  65
ALA T  64
LEU T  25
ALA T  26
None
0.91A 5uanA-5xyiT:
undetectable
5uanA-5xyiT:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi RIBOSOMAL PROTEIN
S19E, PUTATIVE


(Trichomonas
vaginalis)
PF01090
(Ribosomal_S19e)
5 ILE T  68
ALA T  65
LEU T  25
ALA T  26
LEU T 111
None
0.91A 5uanA-5xyiT:
undetectable
5uanA-5xyiT:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zya SPLICING FACTOR 3B
SUBUNIT 1


(Homo sapiens)
no annotation 5 ALA C 672
GLN C 669
LEU C 712
ALA C 711
LEU C 644
None
1.00A 5uanA-5zyaC:
undetectable
5uanA-5zyaC:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY


(Thermobifida
fusca)
no annotation 6 ALA M  42
ALA M  41
GLN M  43
PHE M  39
LEU M 129
ALA M 128
None
A  J   1 ( 3.1A)
None
None
None
None
1.25A 5uanA-6c66M:
undetectable
5uanA-6c66M:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d95 -

(-)
no annotation 5 ILE A 129
ALA A 132
ALA A 133
LEU A 267
ALA A 266
None
0.54A 5uanA-6d95A:
undetectable
5uanA-6d95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhs RUVB-LIKE HELICASE

(Chaetomium
thermophilum)
no annotation 6 ILE A  84
ALA A  83
GLN A  86
PHE A  94
LEU A  88
VAL A  67
None
1.38A 5uanA-6fhsA:
undetectable
5uanA-6fhsA:
13.90