SIMILAR PATTERNS OF AMINO ACIDS FOR 5UAN_A_9CRA503_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1air | PECTATE LYASE C (Dickeyachrysanthemi) |
PF00544(Pec_lyase_C) | 5 | ILE A 33ALA A 36ALA A 35ALA A 49VAL A 82 | None | 0.96A | 5uanA-1airA:undetectable | 5uanA-1airA:24.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dqu | ISOCITRATE LYASE (Aspergillusnidulans) |
PF00463(ICL) | 5 | ILE A 166ALA A 192ALA A 191LEU A 59ALA A 56 | None | 0.96A | 5uanA-1dquA:undetectable | 5uanA-1dquA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e19 | CARBAMATE KINASE (Pyrococcusfuriosus) |
PF00696(AA_kinase) | 6 | ILE A 37ALA A 34LEU A 97ALA A 96VAL A 5LEU A 234 | None | 0.94A | 5uanA-1e19A:undetectable | 5uanA-1e19A:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fc4 | 2-AMINO-3-KETOBUTYRATE CONENZYME ALIGASE (Escherichiacoli) |
PF00155(Aminotran_1_2) | 5 | ILE A 238ALA A 255ALA A 256LEU A 100ALA A 97 | None | 0.90A | 5uanA-1fc4A:undetectable | 5uanA-1fc4A:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fs5 | GLUCOSAMINE-6-PHOSPHATE DEAMINASE (Escherichiacoli) |
PF01182(Glucosamine_iso) | 5 | ILE A 20ALA A 17ALA A 16LEU A 52ALA A 51 | None | 0.94A | 5uanA-1fs5A:undetectable | 5uanA-1fs5A:21.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hg4 | ULTRASPIRACLE (Drosophilamelanogaster) |
PF00104(Hormone_recep) | 5 | TRP A 318LEU A 366VAL A 382CYH A 472LEU A 476 | NoneLPP A 1 ( 4.4A)LPP A 1 (-4.8A)LPP A 1 ( 4.2A)LPP A 1 (-4.2A) | 0.81A | 5uanA-1hg4A:24.3 | 5uanA-1hg4A:32.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kqj | A/G-SPECIFIC ADENINEGLYCOSYLASE (Escherichiacoli) |
PF00633(HHH)PF00730(HhH-GPD) | 5 | ALA A 93ALA A 92GLN A 94LEU A 65ALA A 66 | None | 0.87A | 5uanA-1kqjA:undetectable | 5uanA-1kqjA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n60 | CARBON MONOXIDEDEHYDROGENASE SMALLCHAIN (Oligotrophacarboxidovorans) |
PF00111(Fer2)PF01799(Fer2_2) | 5 | ILE A 149ALA A 152ALA A 153LEU A 90ALA A 89 | None | 0.83A | 5uanA-1n60A:undetectable | 5uanA-1n60A:18.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pcg | ESTROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 5 | ALA A 350TRP A 383ARG A 394VAL A 418LEU A 525 | EST A 1 ( 3.7A)NoneEST A 1 (-3.7A)NoneEST A 1 (-3.6A) | 1.00A | 5uanA-1pcgA:25.1 | 5uanA-1pcgA:24.60 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1r20 | ULTRASPIRACLEPROTEIN (Heliothisvirescens) |
PF00104(Hormone_recep) | 5 | TRP A 286ARG A 297LEU A 325VAL A 341LEU A 435 | NoneNoneNoneEPH A4000 (-4.9A)EPH A4000 ( 4.6A) | 0.59A | 5uanA-1r20A:24.2 | 5uanA-1r20A:33.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1uhl | RETINOIC ACIDRECEPTOR RXR-BETA (Homo sapiens) |
PF00104(Hormone_recep) | 12 | ILE A 339ALA A 342ALA A 343GLN A 346TRP A 376PHE A 384ARG A 387LEU A 397ALA A 398VAL A 413CYH A 503LEU A 507 | MEI A1001 (-3.8A)MEI A1001 (-3.1A)MEI A1001 (-3.3A)NoneNoneMEI A1001 (-4.5A)MEI A1001 (-3.6A)MEI A1001 ( 4.4A)MEI A1001 (-3.4A)MEI A1001 (-4.1A)MEI A1001 (-4.0A)MEI A1001 (-4.6A) | 0.77A | 5uanA-1uhlA:33.6 | 5uanA-1uhlA:66.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v6c | ALKALINE SERINEPROTEASE (Pseudoalteromonassp. AS-11) |
PF00082(Peptidase_S8)PF02225(PA) | 5 | ILE A 114ALA A 113TRP A 104VAL A 174LEU A 130 | NoneNoneNone CA A 505 (-4.5A)PMS A 501 (-4.5A) | 1.02A | 5uanA-1v6cA:undetectable | 5uanA-1v6cA:20.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1xiu | RXR-LIKE PROTEIN (Biomphalariaglabrata) |
PF00104(Hormone_recep) | 12 | ILE A 242ALA A 245ALA A 246GLN A 249TRP A 279PHE A 287ARG A 290LEU A 300ALA A 301VAL A 316CYH A 406LEU A 410 | 9CR A 201 ( 4.4A)9CR A 201 (-3.6A)9CR A 201 (-3.6A)9CR A 201 (-4.1A)None9CR A 201 (-4.7A)9CR A 201 (-2.8A)9CR A 201 (-4.4A)9CR A 201 (-3.4A)9CR A 201 (-4.2A)9CR A 201 (-3.6A)9CR A 201 ( 4.8A) | 0.51A | 5uanA-1xiuA:30.3 | 5uanA-1xiuA:62.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1xls | RETINOIC ACIDRECEPTOR RXR-ALPHA (Homo sapiens) |
PF00104(Hormone_recep) | 12 | ILE A 268ALA A 271ALA A 272GLN A 275TRP A 305PHE A 313ARG A 316LEU A 326ALA A 327VAL A 342CYH A 432LEU A 436 | 9CR A 801 (-3.9A)9CR A 801 (-3.6A)9CR A 801 (-3.5A)9CR A 801 (-4.7A)None9CR A 801 (-4.3A)9CR A 801 (-2.6A)9CR A 801 (-4.1A)9CR A 801 (-3.3A)9CR A 801 ( 4.3A)9CR A 801 ( 3.7A)9CR A 801 (-4.7A) | 0.52A | 5uanA-1xlsA:33.1 | 5uanA-1xlsA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xv9 | ORPHAN NUCLEARRECEPTOR NR1I3 (Homo sapiens) |
PF00104(Hormone_recep) | 5 | ALA B 197ALA B 198LEU B 267ALA B 266LEU B 342 | None | 1.01A | 5uanA-1xv9B:19.9 | 5uanA-1xv9B:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yfm | FUMARASE (Saccharomycescerevisiae) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 5 | ILE A 391ALA A 176ALA A 177GLN A 180LEU A 70 | None | 1.00A | 5uanA-1yfmA:undetectable | 5uanA-1yfmA:23.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1z5x | ULTRASPIRACLEPROTEIN (USP) AHOMOLOGUE OF RXR (Bemisia tabaci) |
PF00104(Hormone_recep) | 5 | ILE U 303ALA U 306ALA U 307LEU U 365ALA U 362 | None | 0.87A | 5uanA-1z5xU:21.8 | 5uanA-1z5xU:53.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z69 | COENZYMEF420-DEPENDENTN(5),N(10)-METHYLENETETRAHYDROMETHANOPTERIN REDUCTASE (Methanosarcinabarkeri) |
PF00296(Bac_luciferase) | 5 | ILE A 258ALA A 257PHE A 263LEU A 266ALA A 265 | None | 1.00A | 5uanA-1z69A:undetectable | 5uanA-1z69A:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zk7 | MERCURIC REDUCTASE (Pseudomonasaeruginosa) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 6 | ALA A 452ALA A 451GLN A 453LEU A 434ALA A 435VAL A 356 | NoneNoneGOL A3003 ( 3.8A)NoneNoneNone | 1.22A | 5uanA-1zk7A:undetectable | 5uanA-1zk7A:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dpn | GLYCEROL KINASE (Thermusthermophilus) |
PF00370(FGGY_N)PF02782(FGGY_C) | 5 | ALA A 57ALA A 58ALA A 29VAL A 163LEU A 171 | None | 0.73A | 5uanA-2dpnA:undetectable | 5uanA-2dpnA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fv2 | RCD1 REQUIRED FORCELLDIFFERENTIATION1HOMOLOG (Homo sapiens) |
PF04078(Rcd1) | 5 | ALA A 85GLN A 82LEU A 130ALA A 129LEU A 51 | None | 0.75A | 5uanA-2fv2A:undetectable | 5uanA-2fv2A:21.39 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2gl8 | RETINOIC ACIDRECEPTOR RXR-GAMMA (Homo sapiens) |
PF00104(Hormone_recep) | 6 | TRP A 84PHE A 92ARG A 95ALA A 106VAL A 121CYH A 211 | None | 0.99A | 5uanA-2gl8A:26.5 | 5uanA-2gl8A:60.97 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2gl8 | RETINOIC ACIDRECEPTOR RXR-GAMMA (Homo sapiens) |
PF00104(Hormone_recep) | 6 | TRP A 84PHE A 92LEU A 105ALA A 106VAL A 121CYH A 211 | None | 0.95A | 5uanA-2gl8A:26.5 | 5uanA-2gl8A:60.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iec | UNCHARACTERIZEDPROTEIN CONSERVED INARCHAEA (Methanopyruskandleri) |
PF04038(DHNA) | 5 | ILE A 49ALA A 52ALA A 53GLN A 56VAL A 66 | None | 0.99A | 5uanA-2iecA:undetectable | 5uanA-2iecA:16.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ji9 | OXALYL-COADECARBOXYLASE (Oxalobacterformigenes) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | ILE A 210ALA A 207ALA A 206LEU A 337ALA A 336 | None | 0.99A | 5uanA-2ji9A:undetectable | 5uanA-2ji9A:21.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2nxx | ULTRASPIRACLE (USP,NR2B4) (Triboliumcastaneum) |
PF00104(Hormone_recep) | 5 | PHE A 259ARG A 262LEU A 272ALA A 273CYH A 378 | None | 0.73A | 5uanA-2nxxA:24.4 | 5uanA-2nxxA:42.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p6w | PUTATIVEGLYCOSYLTRANSFERASE(MANNOSYLTRANSFERASE) INVOLVED INGLYCOSYLATING THEPBCV-1 MAJOR CAPSIDPROTEIN (ParameciumbursariaChlorella virus1) |
PF05637(Glyco_transf_34) | 5 | ILE A 61ALA A 64ALA A 65LEU A 9VAL A 136 | None | 0.90A | 5uanA-2p6wA:undetectable | 5uanA-2p6wA:23.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2q60 | RETINOID X RECEPTOR (Polyandrocarpamisakiensis) |
PF00104(Hormone_recep) | 6 | TRP A 180PHE A 188ARG A 191ALA A 202VAL A 217CYH A 307 | None | 0.77A | 5uanA-2q60A:25.8 | 5uanA-2q60A:53.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q8w | POKEWEED ANTIVIRALPROTEIN (Phytolaccaacinosa) |
PF00161(RIP) | 5 | ILE A 214ALA A 217ARG A 240LEU A 222ALA A 221 | None | 0.95A | 5uanA-2q8wA:undetectable | 5uanA-2q8wA:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qde | MANDELATERACEMASE/MUCONATELACTONIZING ENZYMEFAMILY PROTEIN (Aromatoleumaromaticum) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ILE A 69ALA A 103GLN A 102VAL A 387LEU A 38 | None | 0.96A | 5uanA-2qdeA:undetectable | 5uanA-2qdeA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vml | PHYCOCYANIN ALPHACHAINPHYCOCYANIN BETACHAIN (Gloeobacterviolaceus) |
PF00502(Phycobilisome) | 5 | ALA A 40ALA A 41ALA A 150VAL B 31LEU B 24 | None | 0.83A | 5uanA-2vmlA:undetectable | 5uanA-2vmlA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vsx | EUKARYOTICINITIATION FACTOR 4FSUBUNIT P150 (Saccharomycescerevisiae) |
PF02854(MIF4G) | 5 | ILE E 652ALA E 656LEU E 614VAL E 673LEU E 753 | None | 0.96A | 5uanA-2vsxE:undetectable | 5uanA-2vsxE:24.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xax | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1SUBUNIT ALPHA (Escherichiacoli) |
PF00317(Ribonuc_red_lgN)PF02867(Ribonuc_red_lgC)PF03477(ATP-cone) | 5 | ILE A 62ALA A 66ALA A 65LEU A 84ALA A 81 | None | 1.02A | 5uanA-2xaxA:undetectable | 5uanA-2xaxA:18.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xgo | XCOGT (Xanthomonascampestris) |
PF13432(TPR_16)PF13844(Glyco_transf_41) | 5 | ALA A 549PHE A 228LEU A 231ALA A 230LEU A 328 | None | 0.97A | 5uanA-2xgoA:undetectable | 5uanA-2xgoA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3afg | SUBTILISIN-LIKESERINE PROTEASE (Thermococcuskodakarensis) |
PF00082(Peptidase_S8)PF04151(PPC) | 5 | ILE A 368ALA A 415ALA A 416LEU A 388ALA A 387 | None | 0.96A | 5uanA-3afgA:undetectable | 5uanA-3afgA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ci0 | PSEUDOPILIN GSPK (Escherichiacoli) |
PF03934(T2SSK) | 5 | ILE K 218ALA K 221LEU K 119ALA K 118LEU K 271 | None | 0.95A | 5uanA-3ci0K:undetectable | 5uanA-3ci0K:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d0q | PROTEIN CALG3 (Micromonosporaechinospora) |
PF06722(DUF1205) | 5 | ILE A 233ALA A 236ALA A 237ALA A 334LEU A 246 | None | 0.85A | 5uanA-3d0qA:undetectable | 5uanA-3d0qA:23.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dme | CONSERVED EXPORTEDPROTEIN (Bordetellapertussis) |
PF01266(DAO) | 5 | ILE A 10ALA A 205ALA A 204LEU A 212ALA A 209 | FAD A 500 (-4.5A)FAD A 500 (-3.6A)NoneFAD A 500 ( 4.3A)None | 0.99A | 5uanA-3dmeA:undetectable | 5uanA-3dmeA:22.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dzu | RETINOIC ACIDRECEPTOR RXR-ALPHA (Homo sapiens) |
PF00104(Hormone_recep)PF00105(zf-C4) | 12 | ILE A 268ALA A 271ALA A 272GLN A 275TRP A 305PHE A 313ARG A 316LEU A 326ALA A 327VAL A 342CYH A 432LEU A 436 | 9CR A7223 (-3.9A)9CR A7223 (-3.5A)9CR A7223 (-4.2A)9CR A7223 (-4.6A)None9CR A7223 (-4.5A)9CR A7223 (-3.7A)9CR A7223 (-3.8A)9CR A7223 ( 4.7A)9CR A7223 ( 4.5A)9CR A7223 (-3.8A)9CR A7223 ( 4.7A) | 0.81A | 5uanA-3dzuA:32.9 | 5uanA-3dzuA:78.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h5k | RIBOSOME-INACTIVATING PROTEINPD-L1/PD-L2 (Phytolaccadioica) |
PF00161(RIP) | 5 | ILE A 214ALA A 217ARG A 240LEU A 222ALA A 221 | None | 0.92A | 5uanA-3h5kA:undetectable | 5uanA-3h5kA:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hve | GIGAXONIN (Homo sapiens) |
PF00651(BTB)PF07707(BACK) | 5 | ILE A 47ALA A 50ALA A 51LEU B 20ALA B 19 | None | 0.62A | 5uanA-3hveA:undetectable | 5uanA-3hveA:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hve | GIGAXONIN (Homo sapiens) |
PF00651(BTB)PF07707(BACK) | 5 | ILE A 47ALA A 50LEU B 20ALA B 19LEU A 87 | None | 0.66A | 5uanA-3hveA:undetectable | 5uanA-3hveA:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hve | GIGAXONIN (Homo sapiens) |
PF00651(BTB)PF07707(BACK) | 5 | ILE B 47ALA B 50ALA B 51LEU A 20ALA A 19 | None | 0.68A | 5uanA-3hveB:undetectable | 5uanA-3hveB:17.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hve | GIGAXONIN (Homo sapiens) |
PF00651(BTB)PF07707(BACK) | 5 | ILE B 47ALA B 50LEU A 20ALA A 19LEU B 87 | None | 0.87A | 5uanA-3hveB:undetectable | 5uanA-3hveB:17.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ic5 | PUTATIVESACCHAROPINEDEHYDROGENASE (Ruegeriapomeroyi) |
PF03435(Sacchrp_dh_NADP) | 5 | ILE A 82ALA A 85ALA A 86LEU A 60ALA A 61 | None | 0.73A | 5uanA-3ic5A:undetectable | 5uanA-3ic5A:15.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jru | PROBABLE CYTOSOLAMINOPEPTIDASE (Xanthomonasoryzae) |
no annotation | 5 | ALA B 139ALA B 138LEU B 3ALA B 2VAL B 21 | None | 0.93A | 5uanA-3jruB:undetectable | 5uanA-3jruB:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k11 | PUTATIVE GLYCOSYLHYDROLASE (Bacteroidesthetaiotaomicron) |
PF07470(Glyco_hydro_88) | 5 | ILE A 228ALA A 232ALA A 230GLN A 233LEU A 164 | None | 0.92A | 5uanA-3k11A:undetectable | 5uanA-3k11A:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l6a | EUKARYOTICTRANSLATIONINITIATION FACTOR 4GAMMA 2 (Homo sapiens) |
PF02020(W2)PF02847(MA3) | 5 | ALA A 111GLN A 143LEU A 144VAL A 162LEU A 128 | NoneNoneNoneMES A 361 (-3.6A)None | 1.00A | 5uanA-3l6aA:undetectable | 5uanA-3l6aA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lwg | HP0420 HOMOLOGUE (Helicobacterfelis) |
no annotation | 5 | ILE A 56ALA A 59ALA A 60LEU A 38ALA A 24 | None | 0.96A | 5uanA-3lwgA:undetectable | 5uanA-3lwgA:18.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o0m | HIT FAMILY PROTEIN (Mycolicibacteriumsmegmatis) |
PF01230(HIT) | 5 | ILE A 67ALA A 70ALA A 71LEU A 136ALA A 135 | None | 0.64A | 5uanA-3o0mA:undetectable | 5uanA-3o0mA:16.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o10 | SACSIN (Homo sapiens) |
PF05168(HEPN) | 5 | ALA A4487ALA A4488LEU A4451ALA A4447LEU A4519 | None | 0.88A | 5uanA-3o10A:undetectable | 5uanA-3o10A:17.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oks | 4-AMINOBUTYRATETRANSAMINASE (Mycolicibacteriumsmegmatis) |
PF00202(Aminotran_3) | 5 | ILE A 327ALA A 331ALA A 330LEU A 298ALA A 295 | None | 1.01A | 5uanA-3oksA:undetectable | 5uanA-3oksA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rko | NADH-QUINONEOXIDOREDUCTASESUBUNIT N (Escherichiacoli) |
no annotation | 5 | ILE N 250ALA N 249LEU N 119ALA N 120LEU N 306 | None | 0.89A | 5uanA-3rkoN:undetectable | 5uanA-3rkoN:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ttf | TRANSCRIPTIONALREGULATORY PROTEIN (Escherichiacoli) |
PF01300(Sua5_yciO_yrdC)PF07503(zf-HYPF) | 5 | ALA A 602ALA A 600LEU A 622ALA A 618VAL A 636 | None | 0.94A | 5uanA-3ttfA:undetectable | 5uanA-3ttfA:19.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uc2 | HYPOTHETICAL PROTEINWITHIMMUNOGLOBULIN-LIKEFOLD (Pseudomonasaeruginosa) |
PF14467(DUF4426) | 5 | ILE A 59ALA A 103GLN A 104PHE A 105LEU A 88 | None | 0.93A | 5uanA-3uc2A:undetectable | 5uanA-3uc2A:17.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3upn | PENICILLIN-BINDINGPROTEIN A (Mycobacteriumtuberculosis) |
PF00905(Transpeptidase) | 5 | ALA A 231ALA A 232LEU A 298ALA A 297LEU A 274 | None | 0.95A | 5uanA-3upnA:undetectable | 5uanA-3upnA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wxw | ADIPONECTIN RECEPTORPROTEIN 2 (Homo sapiens) |
PF03006(HlyIII) | 5 | ILE A 322ALA A 325ALA A 326LEU A 283ALA A 279 | None | 0.73A | 5uanA-3wxwA:undetectable | 5uanA-3wxwA:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zil | AAR187CP (Eremotheciumgossypii) |
PF16997(Wap1) | 6 | ILE A 359ALA A 356TRP A 338LEU A 397ALA A 393LEU A 335 | None | 1.28A | 5uanA-3zilA:undetectable | 5uanA-3zilA:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zrg | PEXRD2 FAMILYSECRETED RXLREFFECTOR PEPTIDE,PUTATIVE (Phytophthorainfestans) |
no annotation | 6 | ILE A 86ALA A 89ALA A 90LEU A 99ALA A 95VAL A 73 | NoneNoneNone BR A1122 ( 4.5A)NoneNone | 1.40A | 5uanA-3zrgA:undetectable | 5uanA-3zrgA:10.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a7w | URIDYLATE KINASE (Helicobacterpylori) |
PF00696(AA_kinase) | 5 | ILE A 39ALA A 36LEU A 94ALA A 93VAL A 10 | None | 0.92A | 5uanA-4a7wA:undetectable | 5uanA-4a7wA:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4au0 | EXOGLUCANASE 2 (Trichodermareesei) |
PF01341(Glyco_hydro_6) | 5 | ALA A 280ALA A 279GLN A 281LEU A 336VAL A 323 | None | 0.96A | 5uanA-4au0A:undetectable | 5uanA-4au0A:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b8b | GENERAL NEGATIVEREGULATOR OFTRANSCRIPTIONSUBUNIT 1 (Saccharomycescerevisiae) |
PF16417(CNOT1_TTP_bind)PF16418(CNOT1_HEAT)PF16419(CNOT1_HEAT_N) | 6 | ILE A 741ALA A 744ALA A 745LEU A 714ALA A 715VAL A 728 | None | 1.11A | 5uanA-4b8bA:undetectable | 5uanA-4b8bA:20.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ia4 | AQUAPORIN (Spinaciaoleracea) |
PF00230(MIP) | 5 | ALA A 257ALA A 258GLN A 261LEU A 110ALA A 111 | None | 0.91A | 5uanA-4ia4A:undetectable | 5uanA-4ia4A:21.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4j5x | RETINOIC ACIDRECEPTOR RXR-ALPHA,NUCLEAR RECEPTORCOACTIVATOR 1 (Homo sapiens) |
no annotation | 12 | ILE D 268ALA D 271ALA D 272GLN D 275TRP D 305PHE D 313ARG D 316LEU D 326ALA D 327VAL D 342CYH D 432LEU D 436 | None | 0.74A | 5uanA-4j5xD:32.3 | 5uanA-4j5xD:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jz7 | CARBAMATE KINASE (Giardiaintestinalis) |
PF00696(AA_kinase) | 5 | ILE A 39ALA A 36ALA A 35ALA A 96VAL A 7 | None | 0.89A | 5uanA-4jz7A:undetectable | 5uanA-4jz7A:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jz7 | CARBAMATE KINASE (Giardiaintestinalis) |
PF00696(AA_kinase) | 5 | ILE A 39ALA A 36ALA A 96VAL A 7LEU A 235 | None | 1.00A | 5uanA-4jz7A:undetectable | 5uanA-4jz7A:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ks8 | SERINE/THREONINE-PROTEIN KINASE PAK 6 (Homo sapiens) |
PF00069(Pkinase) | 5 | ILE A 503GLN A 660LEU A 631VAL A 493LEU A 667 | None | 0.93A | 5uanA-4ks8A:undetectable | 5uanA-4ks8A:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m88 | EXTRACELLULARLIGAND-BINDINGRECEPTOR (Verminephrobactereiseniae) |
PF13458(Peripla_BP_6) | 5 | ILE A 191ALA A 188ALA A 187LEU A 215ALA A 214 | None | 0.99A | 5uanA-4m88A:undetectable | 5uanA-4m88A:24.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mij | TRAP DICARBOXYLATETRANSPORTER, DCTPSUBUNIT (Polaromonas sp.JS666) |
PF03480(DctP) | 5 | ILE A 261ALA A 265ALA A 264LEU A 146ALA A 147 | None | 1.00A | 5uanA-4mijA:undetectable | 5uanA-4mijA:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nn1 | TRANSCRIPTIONALREGULATOR (Mycobacteriumtuberculosis) |
PF00440(TetR_N) | 5 | ILE A 12ALA A 15ALA A 16GLN A 19ALA A 35 | None | 0.66A | 5uanA-4nn1A:undetectable | 5uanA-4nn1A:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o7d | GLUTAMINASE KIDNEYISOFORM,MITOCHONDRIAL (Homo sapiens) |
PF04960(Glutaminase) | 6 | ILE A 250ALA A 376GLN A 379ARG A 382VAL A 484CYH A 283 | NoneNoneNoneNoneONL A 601 (-3.7A)None | 1.25A | 5uanA-4o7dA:undetectable | 5uanA-4o7dA:21.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p47 | TRAP DICARBOXYLATETRANSPORTER, DCTPSUBUNIT (Ochrobactrumanthropi) |
PF03480(DctP) | 5 | ILE A 260ALA A 264ALA A 263LEU A 144ALA A 145 | None | 0.95A | 5uanA-4p47A:undetectable | 5uanA-4p47A:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pdd | TRAP DICARBOXYLATETRANSPORTER, DCTPSUBUNIT (Polaromonas sp.JS666) |
PF03480(DctP) | 5 | ALA A 267ALA A 266GLN A 268LEU A 147ALA A 148 | None | 0.93A | 5uanA-4pddA:undetectable | 5uanA-4pddA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pf6 | C4-DICARBOXYLATE-BINDING PROTEIN (Roseobacterdenitrificans) |
PF03480(DctP) | 5 | ILE A 242ALA A 267ALA A 268LEU A 46ALA A 45 | None | 0.99A | 5uanA-4pf6A:undetectable | 5uanA-4pf6A:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rrj | PROBABLETHREONINE--TRNALIGASE 2 (Aeropyrumpernix) |
PF08915(tRNA-Thr_ED) | 5 | ILE A 58ALA A 55ALA A 54LEU A 99ALA A 98 | None | 0.89A | 5uanA-4rrjA:undetectable | 5uanA-4rrjA:16.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uqg | DNA POLYMERASE (Geobacillusstearothermophilus) |
PF00476(DNA_pol_A) | 5 | ILE A 804ALA A 801ALA A 800GLN A 797LEU A 862 | None | 0.96A | 5uanA-4uqgA:undetectable | 5uanA-4uqgA:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4v1u | LYND (Lyngbyaaestuarii) |
PF02624(YcaO) | 6 | ILE A 264ALA A 261ALA A 260LEU A 134ALA A 133LEU A 286 | None | 1.18A | 5uanA-4v1uA:undetectable | 5uanA-4v1uA:17.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x9n | L-ALPHA-GLYCEROPHOSPHATE OXIDASE (Mycoplasmapneumoniae) |
PF01266(DAO) | 5 | ALA A 209ALA A 208LEU A 216ALA A 213VAL A 202 | FAD A 401 (-3.6A)NoneNoneNoneNone | 0.97A | 5uanA-4x9nA:undetectable | 5uanA-4x9nA:25.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xa8 | D-ISOMER SPECIFIC2-HYDROXYACIDDEHYDROGENASENAD-BINDING (Xanthobacterautotrophicus) |
PF02826(2-Hacid_dh_C) | 5 | ILE A 296ALA A 293ALA A 292LEU A 25ALA A 24 | None | 0.91A | 5uanA-4xa8A:undetectable | 5uanA-4xa8A:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xbo | TRNA(CYTIDINE/URIDINE-2'-O-)-METHYLTRANSFERASE TRMJ (Escherichiacoli) |
PF00588(SpoU_methylase) | 6 | ALA A 53ALA A 22LEU A 49ALA A 50VAL A 40LEU A 9 | None | 1.15A | 5uanA-4xboA:undetectable | 5uanA-4xboA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xbo | TRNA(CYTIDINE/URIDINE-2'-O-)-METHYLTRANSFERASE TRMJ (Escherichiacoli) |
PF00588(SpoU_methylase) | 6 | ILE A 57ALA A 53ALA A 22LEU A 49ALA A 50LEU A 9 | None | 1.46A | 5uanA-4xboA:undetectable | 5uanA-4xboA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xgj | UNCHARACTERIZEDPROTEIN (Pectobacteriumatrosepticum) |
PF07005(DUF1537)PF17042(DUF1357_C) | 5 | ALA A 214ALA A 215LEU A 183ALA A 184LEU A 230 | None | 0.97A | 5uanA-4xgjA:undetectable | 5uanA-4xgjA:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xgj | UNCHARACTERIZEDPROTEIN (Pectobacteriumatrosepticum) |
PF07005(DUF1537)PF17042(DUF1357_C) | 5 | ILE A 211ALA A 214ALA A 215LEU A 183ALA A 184 | None | 0.66A | 5uanA-4xgjA:undetectable | 5uanA-4xgjA:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yk2 | BARTONELLA EFFECTORPROTEIN (BEP)SUBSTRATE OF VIRBT4SS (Bartonellaclarridgeiae) |
no annotation | 5 | ILE A 160ALA A 156PHE A 103LEU A 140ALA A 141 | None | 0.98A | 5uanA-4yk2A:undetectable | 5uanA-4yk2A:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zrs | ESTERASE (unculturedbacterium) |
PF07859(Abhydrolase_3) | 5 | ALA A 97GLN A 100ARG A 286ALA A 282VAL A 135 | None | 0.96A | 5uanA-4zrsA:undetectable | 5uanA-4zrsA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gt5 | PECTATE LYASE (Paenibacillussp. 0602) |
no annotation | 5 | ILE A 117ALA A 116ALA A 115PHE A 132LEU A 39 | None | 1.00A | 5uanA-5gt5A:undetectable | 5uanA-5gt5A:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hj5 | GLUCOSAMINE-6-PHOSPHATE DEAMINASE (Vibrio cholerae) |
PF01182(Glucosamine_iso) | 5 | ILE A 20ALA A 17ALA A 16LEU A 52ALA A 51 | None | 0.93A | 5uanA-5hj5A:undetectable | 5uanA-5hj5A:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iuw | ALDEHYDEDEHYDROGENASE FAMILYPROTEIN (Pseudomonassyringae groupgenomosp. 3) |
no annotation | 5 | ILE A 294ALA A 291ALA A 290LEU A 326ALA A 325 | None | 1.01A | 5uanA-5iuwA:undetectable | 5uanA-5iuwA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m49 | AMINOTRANSFERASECLASS-III (Rhizobiumfreirei) |
PF00202(Aminotran_3) | 5 | ILE A 199ALA A 201ALA A 202VAL A 194LEU A 187 | None | 0.94A | 5uanA-5m49A:undetectable | 5uanA-5m49A:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n0g | PRECORRIN-8XMETHYLMUTASE (Rhodobactercapsulatus) |
no annotation | 6 | ILE A 73ALA A 71ALA A 130LEU A 67ALA A 66VAL A 80 | None | 1.25A | 5uanA-5n0gA:undetectable | 5uanA-5n0gA:12.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ohs | - (-) |
no annotation | 5 | ILE A 257ALA A 260PHE A 541LEU A 538ALA A 539 | None | 0.89A | 5uanA-5ohsA:undetectable | 5uanA-5ohsA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u4o | ABC TRANSPORTERSUBSTRATE-BINDINGPROTEIN (Bacillusanthracis) |
PF00496(SBP_bac_5) | 6 | ILE A 304ALA A 305ALA A 303GLN A 302ALA A 484VAL A 393 | None | 1.34A | 5uanA-5u4oA:undetectable | 5uanA-5u4oA:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ui2 | ORANGECAROTENOID-BINDINGPROTEIN (Arthrospiramaxima) |
PF02136(NTF2)PF09150(Carot_N) | 5 | ILE A 305ALA A 304LEU A 225ALA A 224VAL A 275 | EQ3 A 403 ( 3.8A)NoneNoneNoneEQ3 A 403 (-4.7A) | 0.95A | 5uanA-5ui2A:undetectable | 5uanA-5ui2A:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xyi | RIBOSOMAL PROTEINS19E, PUTATIVE (Trichomonasvaginalis) |
PF01090(Ribosomal_S19e) | 5 | ILE T 68ALA T 65ALA T 64LEU T 25ALA T 26 | None | 0.91A | 5uanA-5xyiT:undetectable | 5uanA-5xyiT:16.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xyi | RIBOSOMAL PROTEINS19E, PUTATIVE (Trichomonasvaginalis) |
PF01090(Ribosomal_S19e) | 5 | ILE T 68ALA T 65LEU T 25ALA T 26LEU T 111 | None | 0.91A | 5uanA-5xyiT:undetectable | 5uanA-5xyiT:16.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zya | SPLICING FACTOR 3BSUBUNIT 1 (Homo sapiens) |
no annotation | 5 | ALA C 672GLN C 669LEU C 712ALA C 711LEU C 644 | None | 1.00A | 5uanA-5zyaC:undetectable | 5uanA-5zyaC:11.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c66 | CRISPR-ASSOCIATEDPROTEIN, CAS5EFAMILY (Thermobifidafusca) |
no annotation | 6 | ALA M 42ALA M 41GLN M 43PHE M 39LEU M 129ALA M 128 | None A J 1 ( 3.1A)NoneNoneNoneNone | 1.25A | 5uanA-6c66M:undetectable | 5uanA-6c66M:16.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d95 | - (-) |
no annotation | 5 | ILE A 129ALA A 132ALA A 133LEU A 267ALA A 266 | None | 0.54A | 5uanA-6d95A:undetectable | 5uanA-6d95A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fhs | RUVB-LIKE HELICASE (Chaetomiumthermophilum) |
no annotation | 6 | ILE A 84ALA A 83GLN A 86PHE A 94LEU A 88VAL A 67 | None | 1.38A | 5uanA-6fhsA:undetectable | 5uanA-6fhsA:13.90 |