SIMILAR PATTERNS OF AMINO ACIDS FOR 5UAH_C_RFPC3001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a1s ORNITHINE
CARBAMOYLTRANSFERASE

(Pyrococcus
furiosus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 ARG A   7
GLN A  13
LEU A  12
VAL A 125
SER A 133
 None
 1.45A 5uahC-1a1sA:
0.0		 5uahC-1a1sA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dnp DNA PHOTOLYASE

(Escherichia
coli) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 VAL A 169
ARG A 249
LEU A 161
ARG A 160
ILE A 133
 None
 1.47A 5uahC-1dnpA:
0.0		 5uahC-1dnpA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01063
(Aminotran_4) 		5 ARG A 220
LEU A 226
LEU A 296
PRO A 333
ILE A 332
 None
 1.35A 5uahC-1kt8A:
0.4		 5uahC-1kt8A:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxy ARGININE DEIMINASE

(Mycoplasma
arginini) 		PF02274
(Amidinotransf) 		5 LEU A  24
VAL A 217
SER A 187
PRO A 206
ILE A 172
 None
 1.33A 5uahC-1lxyA:
0.0		 5uahC-1lxyA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvr CLPB PROTEIN

(Thermus
thermophilus) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 LEU A 160
VAL A 258
LEU A 211
PRO A 194
ILE A 303
 None
 1.36A 5uahC-1qvrA:
0.0		 5uahC-1qvrA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6b CLPA PROTEIN

(Escherichia
coli) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 GLN X 507
VAL X 460
SER X 509
LEU X 516
ARG X 518
 None
ADP  X 781 (-3.8A)
None
None
None
 1.23A 5uahC-1r6bX:
0.0		 5uahC-1r6bX:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE

(Arabidopsis
thaliana) 		PF07992
(Pyr_redox_2) 		5 LEU A 234
VAL A 226
LEU A 239
ILE A 151
ARG A 176
 None
 1.33A 5uahC-1vdcA:
0.0		 5uahC-1vdcA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjz ENDOGLUCANASE

(Thermotoga
maritima) 		PF00150
(Cellulase) 		5 ARG A 159
LEU A 136
LEU A  85
ILE A 120
ARG A 122
 None
 1.32A 5uahC-1vjzA:
0.0		 5uahC-1vjzA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1t ACYL TRANSFERASE

(Chrysanthemum x
morifolium) 		PF02458
(Transferase) 		5 LEU A  37
LEU A  29
ARG A 209
PRO A  78
ILE A  95
 None
 1.38A 5uahC-2e1tA:
0.2		 5uahC-2e1tA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m5w LUPUS LA PROTEIN

(Dictyostelium
discoideum) 		PF05383
(La) 		5 GLN A  59
VAL A  80
SER A  55
LEU A  60
ILE A   9
 None
 1.23A 5uahC-2m5wA:
undetectable		 5uahC-2m5wA:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 GLN A 213
LEU A 212
VAL A 251
PRO A 157
ILE A 158
 None
 1.23A 5uahC-2nq5A:
undetectable		 5uahC-2nq5A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE

(Homo sapiens) 		PF00368
(HMG-CoA_red) 		5 LEU A 821
GLN A 837
ARG A 840
LEU A 544
ARG A 582
 None
 1.42A 5uahC-2r4fA:
0.5		 5uahC-2r4fA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2va8 SKI2-TYPE HELICASE

(Sulfolobus
solfataricus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 ARG A  78
SER A 617
LEU A 614
ILE A 500
ARG A 130
 SO4  A1706 (-3.6A)
None
None
None
None
 1.24A 5uahC-2va8A:
undetectable		 5uahC-2va8A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3keh GLUCOCEREBROSIDASE

(Homo sapiens) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		5 ARG A  39
LEU A 470
LEU A  66
PRO A 475
ARG A 496
 None
 1.42A 5uahC-3kehA:
0.0		 5uahC-3kehA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, BETA
CHAIN

(Escherichia
coli) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 ARG B 467
GLN B  24
VAL B 162
LEU B  21
ILE B 158
 None
 1.34A 5uahC-3pcoB:
undetectable		 5uahC-3pcoB:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prh TRYPTOPHANYL-TRNA
SYNTHETASE

(Bacillus
subtilis) 		PF00579
(tRNA-synt_1b) 		5 ARG A 299
LEU A 291
ARG A 287
PRO A  73
ILE A 300
 None
 1.28A 5uahC-3prhA:
undetectable		 5uahC-3prhA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Coxiella
burnetii) 		PF00275
(EPSP_synthase) 		5 LEU A 132
ARG A  99
SER A 102
LEU A 148
ILE A  98
 None
 1.46A 5uahC-3tr1A:
undetectable		 5uahC-3tr1A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m2g L-ARGININE
BETA-HYDROXYLASE

(Streptomyces
lavendulae) 		PF02668
(TauD) 		5 LEU A 328
ARG A 330
SER A 331
LEU A 343
PRO A 161
 None
 1.39A 5uahC-4m2gA:
undetectable		 5uahC-4m2gA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q73 PROLINE
DEHYDROGENASE

(Bradyrhizobium
diazoefficiens) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		5 LEU A 900
GLN A 801
VAL A 804
SER A 925
ILE A 922
 None
 1.18A 5uahC-4q73A:
1.2		 5uahC-4q73A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnl POSSIBLE GALACTOSE
MUTAROTASE

(Streptomyces
platensis) 		PF01263
(Aldose_epim) 		5 ARG A 134
SER A 108
LEU A 100
PRO A 313
ILE A  86
 None
 1.18A 5uahC-4rnlA:
0.0		 5uahC-4rnlA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s28 PHOSPHOMETHYLPYRIMID
INE SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01964
(ThiC_Rad_SAM) 		5 GLN A 437
LEU A 440
GLN A 439
PRO A 453
ILE A 474
 None
 1.39A 5uahC-4s28A:
undetectable		 5uahC-4s28A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yeb FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3

(Mus musculus) 		PF13855
(LRR_8) 		5 ARG B 234
LEU B 232
LEU B 204
PRO B 170
ILE B 169
 None
 1.20A 5uahC-4yebB:
undetectable		 5uahC-4yebB:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Bacillus sp.
JAMB750) 		PF02156
(Glyco_hydro_26) 		5 ARG A 209
GLN A 285
LEU A 283
LEU A 301
ILE A 348
 CAC  A 501 ( 4.9A)
None
None
None
None
 1.10A 5uahC-4yn5A:
undetectable		 5uahC-4yn5A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5du2 ESPG2
GLYCOSYLTRANSFERASE

(Actinomadura
verrucosospora) 		PF00201
(UDPGT) 		5 LEU A  30
LEU A  11
PRO A 131
ILE A 129
ARG A 212
 None
 1.39A 5uahC-5du2A:
undetectable		 5uahC-5du2A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7q ACYL-COA SYNTHETASE

(Streptomyces
platensis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ARG A  38
LEU A  70
LEU A 104
ARG A 130
ILE A  51
 None
 1.27A 5uahC-5e7qA:
undetectable		 5uahC-5e7qA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5

(Arabidopsis
thaliana) 		PF00149
(Metallophos)
PF00515
(TPR_1)
PF08321
(PPP5)
PF13431
(TPR_17) 		5 LEU A 206
VAL A 172
LEU A 285
PRO A 246
ILE A 283
 None
 1.18A 5uahC-5jjtA:
undetectable		 5uahC-5jjtA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nws SAACMM

(Streptomyces
antibioticus) 		no annotation 5 LEU A 262
ARG A 195
PRO A 189
ILE A 188
ARG A 229
 None
 1.20A 5uahC-5nwsA:
undetectable		 5uahC-5nwsA:
4.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		10 ARG C 164
GLN C 426
LEU C 427
GLN C 429
ARG C 445
SER C 447
LEU C 449
ARG C 456
PRO C 480
ILE C 488
 None
 0.90A 5uahC-5tw1C:
36.8		 5uahC-5tw1C:
45.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		10 ARG C 164
GLN C 426
LEU C 427
GLN C 429
ARG C 445
SER C 447
LEU C 449
PRO C 480
ILE C 488
ARG C 604
 None
 1.08A 5uahC-5tw1C:
36.8		 5uahC-5tw1C:
45.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029

(Streptococcus
pneumoniae) 		no annotation 5 ARG A 127
LEU A 156
VAL A 199
LEU A 153
ARG A 135
 P6G  A 503 (-3.5A)
None
None
None
None
 1.50A 5uahC-5xj1A:
2.0		 5uahC-5xj1A:
16.88