SIMILAR PATTERNS OF AMINO ACIDS FOR 5UAC_C_RFPC3001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w66 LIPOYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF03099
(BPL_LplA_LipB) 		5 GLN A  87
PHE A 159
HIS A  83
LEU A 167
PRO A 175
 None
None
DKA  A 301 ( 4.9A)
None
None
 1.47A 5uacC-1w66A:
undetectable		 5uacC-1w66A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ac5 MAP
KINASE-INTERACTING
SERINE/THREONINE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 PHE A 195
ASP A 194
HIS A 197
SER A 270
ILE A 271
 None
 1.46A 5uacC-2ac5A:
0.7		 5uacC-2ac5A:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h01 2-CYS PEROXIREDOXIN

(Plasmodium
yoelii) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		5 ASP A  71
HIS A  76
LEU A  51
PRO A  45
ILE A  48
 None
 1.39A 5uacC-2h01A:
0.0		 5uacC-2h01A:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE

(Lactococcus
lactis) 		PF00232
(Glyco_hydro_1) 		5 PHE A 186
HIS A 190
SER A 195
ILE A 135
ARG A 277
 None
 1.43A 5uacC-2pbgA:
0.0		 5uacC-2pbgA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cux MALATE SYNTHASE

(Bacillus
anthracis) 		PF01274
(Malate_synthase) 		5 GLN A 230
ASP A 264
HIS A 265
LEU A 200
PRO A  81
 None
 1.35A 5uacC-3cuxA:
0.0		 5uacC-3cuxA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmb DIMERIC PROTEIN OF
UNKNOWN FUNCTION AND
FERREDOXIN-LIKE FOLD

(Bacteroides
fragilis) 		PF07876
(Dabb) 		5 HIS A  78
SER A  61
ARG A  41
PRO A  34
ILE A  43
 SO4  A 100 (-4.0A)
None
None
None
None
 1.35A 5uacC-3fmbA:
0.0		 5uacC-3fmbA:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 GLN B 412
ASP B 415
HIS B 425
ARG B 428
PRO B 459
 None
 0.78A 5uacC-3hkzB:
15.0		 5uacC-3hkzB:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs3 RIBOSE OPERON
REPRESSOR

(Lactobacillus
acidophilus) 		PF13377
(Peripla_BP_3) 		5 ASP A 279
ARG A 315
SER A 317
LEU A 259
ILE A 275
 None
 1.31A 5uacC-3hs3A:
0.0		 5uacC-3hs3A:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mhp FERREDOXIN--NADP
REDUCTASE, LEAF
ISOZYME,
CHLOROPLASTIC

(Pisum sativum) 		PF00175
(NAD_binding_1) 		5 ASP A  78
HIS A  84
ARG A  87
SER A 127
LEU A 112
 None
None
FAD  A 999 (-3.9A)
FAD  A 999 (-2.7A)
FAD  A 999 (-4.4A)
 1.27A 5uacC-3mhpA:
0.1		 5uacC-3mhpA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		5 GLN A 316
ASP A 277
HIS A 226
LEU A 315
ARG A 335
 None
 1.33A 5uacC-3o57A:
0.0		 5uacC-3o57A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fva 5'-TYROSYL-DNA
PHOSPHODIESTERASE

(Caenorhabditis
elegans) 		PF03372
(Exo_endo_phos) 		5 GLN A 157
GLN A 215
HIS A 200
LEU A 156
ILE A 176
 None
 1.06A 5uacC-4fvaA:
undetectable		 5uacC-4fvaA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gew 5'-TYROSYL-DNA
PHOSPHODIESTERASE

(Caenorhabditis
elegans) 		PF03372
(Exo_endo_phos)
PF14555
(UBA_4) 		5 GLN A 157
GLN A 215
HIS A 200
LEU A 156
ILE A 176
 None
None
GOL  A 406 (-4.2A)
None
GOL  A 402 ( 4.8A)
 1.05A 5uacC-4gewA:
undetectable		 5uacC-4gewA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pw1 UNCHARACTERIZED
PROTEIN

([Clostridium]
leptum) 		no annotation 5 GLN A 166
ASP A 168
SER A 248
LEU A  50
ILE A 255
 None
 1.25A 5uacC-4pw1A:
undetectable		 5uacC-4pw1A:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 GLN B 425
ASP B 428
HIS B 438
ARG B 441
PRO B 472
 None
 0.92A 5uacC-4qiwB:
21.4		 5uacC-4qiwB:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cuk RULER PROTEIN

(Pseudomonas
aeruginosa) 		PF02120
(Flg_hook) 		5 GLN A 340
GLN A 334
LEU A 308
ILE A 310
ARG A 326
 GOL  A 402 (-3.9A)
None
GOL  A 402 ( 4.4A)
None
GOL  A 401 (-3.3A)
 1.49A 5uacC-5cukA:
undetectable		 5uacC-5cukA:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)

(Naja atra) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		5 GLN A 593
ASP A 736
SER A 610
PRO A 751
ILE A 613
 None
CA  A 903 (-1.9A)
None
None
None
 1.46A 5uacC-5gz4A:
1.2		 5uacC-5gz4A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7c IMMUNOGLOBULIN
G-BINDING PROTEIN A,
DHR14

(Staphylococcus
aureus;
synthetic
construct) 		PF02216
(B) 		5 GLN A 166
GLN A 206
PHE A 209
LEU A 163
ILE A 176
 None
 1.36A 5uacC-5h7cA:
undetectable		 5uacC-5h7cA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2g DIOL DEHYDRATASE

(Roseburia
inulinivorans) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 GLN A 442
PHE A 550
ASP A 448
SER A 286
ILE A 285
 None
 1.37A 5uacC-5i2gA:
undetectable		 5uacC-5i2gA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5l BACTERIOPHYTOCHROME
PROTEIN

(Agrobacterium
fabrum) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		5 GLN A  32
HIS A  34
SER A 262
ARG A 255
PRO A 284
 None
None
BLA  A 601 (-3.0A)
None
None
 1.38A 5uacC-5i5lA:
2.0		 5uacC-5i5lA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jo7 VETISPIRADIENE
SYNTHASE 1

(Hyoscyamus
muticus) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 ASP A 312
SER A 345
LEU A 349
ILE A 306
ARG A 271
 None
 1.48A 5uacC-5jo7A:
1.0		 5uacC-5jo7A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 GLN A3826
PHE A3832
ASP A3834
LEU A4139
PRO A4040
 None
 1.48A 5uacC-5nugA:
undetectable		 5uacC-5nugA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojr -

(-) 		no annotation 5 GLN A 108
HIS A 123
SER A 106
ARG A 190
ILE A 147
 None
 1.41A 5uacC-5ojrA:
1.2		 5uacC-5ojrA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		9 GLN C 426
ASP C 432
HIS C 442
ARG C 445
SER C 447
LEU C 449
ARG C 456
PRO C 480
ILE C 488
 None
 0.92A 5uacC-5tw1C:
39.9		 5uacC-5tw1C:
45.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		9 GLN C 426
ASP C 432
HIS C 442
ARG C 445
SER C 447
LEU C 449
PRO C 480
ILE C 488
ARG C 604
 None
 1.19A 5uacC-5tw1C:
39.9		 5uacC-5tw1C:
45.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		9 GLN C 426
GLN C 429
ASP C 432
HIS C 442
ARG C 445
SER C 447
ARG C 456
PRO C 480
ILE C 488
 None
 0.82A 5uacC-5tw1C:
39.9		 5uacC-5tw1C:
45.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		9 GLN C 426
GLN C 429
ASP C 432
HIS C 442
ARG C 445
SER C 447
PRO C 480
ILE C 488
ARG C 604
 None
 1.11A 5uacC-5tw1C:
39.9		 5uacC-5tw1C:
45.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		9 GLN C 429
PHE C 430
ASP C 432
HIS C 442
ARG C 445
SER C 447
ARG C 456
PRO C 480
ILE C 488
 None
 0.93A 5uacC-5tw1C:
39.9		 5uacC-5tw1C:
45.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		9 GLN C 429
PHE C 430
ASP C 432
HIS C 442
ARG C 445
SER C 447
PRO C 480
ILE C 488
ARG C 604
 None
 1.16A 5uacC-5tw1C:
39.9		 5uacC-5tw1C:
45.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6u CYTOCHROME P450

(Rhodopseudomonas
palustris) 		no annotation 5 GLN A  38
ASP A  33
ARG A 397
ARG A 290
ARG A 390
 None
 1.49A 5uacC-5u6uA:
undetectable		 5uacC-5u6uA:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bv2 AMINOPEPTIDASE N

(Sus scrofa) 		no annotation 5 PHE A 663
ASP A 661
LEU A 647
PRO A 651
ILE A 650
 None
 1.49A 5uacC-6bv2A:
undetectable		 5uacC-6bv2A:
5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cza -

(-) 		no annotation 5 ASP B   8
SER B 201
LEU B 193
PRO B 209
ILE B 204
 None
 1.36A 5uacC-6czaB:
undetectable		 5uacC-6czaB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE

(Bacteroides
thetaiotaomicron) 		no annotation 5 GLN A 380
ASP A 372
SER A 405
LEU A 387
ILE A 409
 None
 1.13A 5uacC-6f8zA:
0.8		 5uacC-6f8zA:
5.13