SIMILAR PATTERNS OF AMINO ACIDS FOR 5U98_D_1KXD301
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ed3 | CLASS I MAJORHISTOCOMPATIBILITYANTIGEN RT1-AA (Rattusnorvegicus) |
PF00129(MHC_I)PF07654(C1-set) | 7 | TYR A 9TYR A 74ILE A 95TYR A 99TYR A 123ILE A 124TRP A 147 | None | 0.56A | 5u98D-1ed3A:34.1 | 5u98D-1ed3A:74.55 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1nez | H-2 CLASS IHISTOCOMPATIBILITYANTIGEN, TLA(C)ALPHA CHAIN (Mus musculus) |
PF00129(MHC_I)PF07654(C1-set) | 7 | TYR A 9ILE A 95VAL A 97TYR A 99TYR A 123ILE A 124TRP A 147 | None | 0.50A | 5u98D-1nezA:28.6 | 5u98D-1nezA:66.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1poi | GLUTACONATE COENZYMEA-TRANSFERASE (Acidaminococcusfermentans) |
PF01144(CoA_trans) | 5 | TYR A 207ILE A 209VAL A 175ASP A 19ILE A 44 | None | 1.47A | 5u98D-1poiA:undetectable | 5u98D-1poiA:20.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1s7s | H-2 CLASS IHISTOCOMPATIBILITYANTIGEN, K-B ALPHACHAIN (Mus musculus) |
PF00129(MHC_I)PF07654(C1-set) | 5 | ILE A 95VAL A 97TYR A 123ILE A 124TRP A 147 | None | 0.26A | 5u98D-1s7sA:34.1 | 5u98D-1s7sA:70.65 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1tmc | CLASS IHISTOCOMPATIBILITYANTIGEN (HLA-AW68) (Homo sapiens) |
PF00129(MHC_I) | 6 | TYR A 9ILE A 95TYR A 99TYR A 123ILE A 124TRP A 147 | None | 0.48A | 5u98D-1tmcA:28.3 | 5u98D-1tmcA:81.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v2a | GLUTATHIONETRANSFERASE GST1-6 (Anopheles dirus) |
PF00043(GST_C)PF13417(GST_N_3) | 5 | TYR A 5TYR A 3ILE A 67SER A 14ILE A 155 | None | 1.37A | 5u98D-1v2aA:undetectable | 5u98D-1v2aA:19.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xdp | POLYPHOSPHATE KINASE (Escherichiacoli) |
PF02503(PP_kinase)PF13089(PP_kinase_N)PF13090(PP_kinase_C) | 5 | TYR A 596ILE A 597VAL A 595ASP A 593ILE A 640 | None | 1.50A | 5u98D-1xdpA:undetectable | 5u98D-1xdpA:17.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jjq | UNCHARACTERIZED RNAMETHYLTRANSFERASEPYRAB10780 (Pyrococcusabyssi) |
PF05958(tRNA_U5-meth_tr) | 5 | TYR A 174VAL A 191SER A 212TYR A 210ILE A 225 | None | 1.10A | 5u98D-2jjqA:undetectable | 5u98D-2jjqA:20.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ol3 | ALLOGENEIC H-2KBM8MHC CLASS I MOLECULE (Mus musculus) |
PF00129(MHC_I)PF07654(C1-set) | 5 | ILE H 95VAL H 97TYR H 123ILE H 124TRP H 147 | None | 0.26A | 5u98D-2ol3H:30.9 | 5u98D-2ol3H:71.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2qri | H-2 CLASS IHISTOCOMPATIBILITYANTIGEN K-B ALPHACHAIN, BETA-2MICROGLOBULIN,OVALBUMIN-DERIVEDPEPTIDE (Mus musculus) |
PF00129(MHC_I)PF07654(C1-set) | 5 | ILE A 95VAL A 97TYR A 123ILE A 124TRP A 147 | None | 0.29A | 5u98D-2qriA:29.0 | 5u98D-2qriA:55.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qyb | MEMBRANE PROTEIN,PUTATIVE (Geobactersulfurreducens) |
PF13185(GAF_2) | 5 | TYR A 52ILE A 38VAL A 37SER A 125ILE A 73 | None | 1.10A | 5u98D-2qybA:undetectable | 5u98D-2qybA:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r7y | RIBONUCLEASE H (Bacillushalodurans) |
no annotation | 5 | TYR A 119ILE A 129ASP A 87SER A 69TYR A 130 | None | 1.17A | 5u98D-2r7yA:undetectable | 5u98D-2r7yA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vx4 | CELLVIBRIO JAPONICUSMANNANASE CJMAN26C (Cellvibriojaponicus) |
PF02156(Glyco_hydro_26) | 5 | TYR A 263ILE A 291VAL A 289ASP A 286TYR A 69 | None | 1.43A | 5u98D-2vx4A:undetectable | 5u98D-2vx4A:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w8s | PHOSPHONATEMONOESTER HYDROLASE (Paraburkholderiacaryophylli) |
PF00884(Sulfatase)PF16347(DUF4976) | 5 | TYR A 199ILE A 103VAL A 135SER A 134ILE A 128 | None | 1.47A | 5u98D-2w8sA:2.4 | 5u98D-2w8sA:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3egj | N-ACETYLGLUCOSAMINE-6-PHOSPHATEDEACETYLASE (Vibrio cholerae) |
PF01979(Amidohydro_1) | 5 | TYR A 375TYR A 2ILE A 23VAL A 370ILE A 349 | None | 1.47A | 5u98D-3egjA:undetectable | 5u98D-3egjA:22.56 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3jts | MHC CLASS IMAMU-A*02 (Macaca mulatta) |
PF00129(MHC_I)PF07654(C1-set) | 7 | TYR A 9ILE A 95TYR A 99SER A 116TYR A 123ILE A 124TRP A 147 | None | 0.79A | 5u98D-3jtsA:32.8 | 5u98D-3jtsA:86.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mbw | EPHRIN-A1 (Homo sapiens) |
PF00812(Ephrin) | 5 | ILE B 39VAL B 145TYR B 127ILE B 49TRP B 25 | None | 1.43A | 5u98D-3mbwB:undetectable | 5u98D-3mbwB:18.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3of7 | REGULATOR OFCHROMOSOMECONDENSATION (Saccharomycescerevisiae) |
PF00415(RCC1)PF13540(RCC1_2) | 5 | ILE A 223VAL A 186TYR A 187ILE A 233TRP A 245 | None | 1.35A | 5u98D-3of7A:undetectable | 5u98D-3of7A:20.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3pwv | MHC CLASS I ANTIGEN (Bos taurus) |
PF00129(MHC_I)PF07654(C1-set) | 5 | TYR A 8TYR A 98TYR A 122ILE A 123TRP A 146 | None | 0.18A | 5u98D-3pwvA:34.4 | 5u98D-3pwvA:79.56 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3qq3 | MHC CLASS I ANTIGEN (Sus scrofa) |
PF00129(MHC_I)PF07654(C1-set) | 6 | TYR A 9TYR A 74TYR A 99TYR A 123ILE A 124TRP A 147 | None | 0.23A | 5u98D-3qq3A:34.0 | 5u98D-3qq3A:74.55 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3rl2 | HLA CLASS IHISTOCOMPATIBILITYANTIGEN, A-3 ALPHACHAIN (Homo sapiens) |
PF00129(MHC_I)PF07654(C1-set) | 5 | ILE A 95TYR A 99TYR A 123ILE A 124TRP A 147 | None | 0.37A | 5u98D-3rl2A:31.9 | 5u98D-3rl2A:87.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3rwg | MAJORHISTOCOMPATIBILITYCOMPLEX CLASS I (Macaca mulatta) |
PF00129(MHC_I)PF07654(C1-set) | 7 | TYR A 9ILE A 95TYR A 99SER A 116TYR A 123ILE A 124TRP A 147 | None | 0.36A | 5u98D-3rwgA:33.8 | 5u98D-3rwgA:85.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3unf | PROTEASOME SUBUNITBETA TYPE-10 (Mus musculus) |
PF00227(Proteasome)PF12465(Pr_beta_C) | 5 | ILE H 37VAL H 100TYR H 111TYR H 42ILE H 178 | None | 1.48A | 5u98D-3unfH:undetectable | 5u98D-3unfH:26.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wau | 4-O-BETA-D-MANNOSYL-D-GLUCOSEPHOSPHORYLASE (Bacteroidesfragilis) |
PF04041(Glyco_hydro_130) | 5 | ILE A 107VAL A 349TYR A 340TYR A 83ILE A 329 | None | 1.27A | 5u98D-3wauA:undetectable | 5u98D-3wauA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e2o | ALPHA-AMYLASE (Geobacillusthermoleovorans) |
PF00128(Alpha-amylase) | 5 | TYR A 351ILE A 355TYR A 350ASP A 311ILE A 333 | None | 1.45A | 5u98D-4e2oA:undetectable | 5u98D-4e2oA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gah | THIOESTERASESUPERFAMILY MEMBER 4 (Homo sapiens) |
PF03061(4HBT) | 5 | ILE A 188VAL A 214SER A 224TYR A 184ILE A 182 | None | 1.09A | 5u98D-4gahA:undetectable | 5u98D-4gahA:18.40 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4lcy | HLA CLASS IHISTOCOMPATIBILITYANTIGEN, B-46 ALPHACHAIN (Homo sapiens) |
PF00129(MHC_I)PF07654(C1-set) | 6 | TYR A 9TYR A 99ASP A 114TYR A 123ILE A 124TRP A 147 | None | 0.34A | 5u98D-4lcyA:34.6 | 5u98D-4lcyA:93.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uy4 | SPINDLIN-4 (Homo sapiens) |
PF02513(Spin-Ssty) | 5 | ILE A 76ASP A 92TYR A 85ILE A 228TRP A 49 | None | 1.29A | 5u98D-4uy4A:undetectable | 5u98D-4uy4A:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ah5 | LEUCINE--TRNA LIGASE (Agrobacteriumtumefaciens) |
PF00133(tRNA-synt_1)PF08264(Anticodon_1)PF13603(tRNA-synt_1_2) | 5 | TYR A 500TYR A 34ILE A 517TYR A 496ILE A 550 | None | 1.32A | 5u98D-5ah5A:undetectable | 5u98D-5ah5A:16.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e9u | GLYCOSYLTRANSFERASE-STABILIZING PROTEINGTF2 (Streptococcusgordonii) |
no annotation | 5 | ILE B 31VAL B 30TYR B 8SER B 43TYR B 45 | None | 1.45A | 5u98D-5e9uB:undetectable | 5u98D-5e9uB:20.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5f1n | MHC CLASS I ANTIGEN (Canis lupus) |
PF00129(MHC_I)PF07654(C1-set) | 7 | TYR A 9TYR A 74ILE A 95TYR A 99TYR A 123ILE A 124TRP A 147 | None | 0.33A | 5u98D-5f1nA:33.8 | 5u98D-5f1nA:80.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fm5 | MYOMESIN-1 (Homo sapiens) |
PF00041(fn3) | 5 | ILE M 528VAL M 516SER M 599ILE M 581TRP M 556 | None | 0.96A | 5u98D-5fm5M:4.1 | 5u98D-5fm5M:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fm8 | MYOMESIN-1 (Homo sapiens) |
PF00041(fn3) | 5 | ILE A 528VAL A 516SER A 599ILE A 581TRP A 556 | None | 0.99A | 5u98D-5fm8A:3.8 | 5u98D-5fm8A:15.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hh7 | ORIGIN OFREPLICATION COMPLEXSUBUNIT 1B (Arabidopsisthaliana) |
PF00628(PHD)PF01426(BAH) | 5 | ILE A 252VAL A 148TYR A 149ILE A 299TRP A 270 | None | 1.39A | 5u98D-5hh7A:undetectable | 5u98D-5hh7A:18.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5j6g | H-2 CLASS IHISTOCOMPATIBILITYANTIGEN, Q10 ALPHACHAIN (Mus musculus) |
PF00129(MHC_I)PF07654(C1-set) | 5 | ILE A 95TYR A 99TYR A 123ILE A 124TRP A 147 | None | 0.26A | 5u98D-5j6gA:32.7 | 5u98D-5j6gA:75.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ly6 | PNEUMOLYSIN (Streptococcuspneumoniae) |
PF01289(Thiol_cytolysin)PF17440(Thiol_cytolys_C) | 5 | TYR B 242TYR B 200VAL B 202TYR B 71SER B 203 | None | 1.30A | 5u98D-5ly6B:undetectable | 5u98D-5ly6B:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5me3 | SISTER CHROMATIDCOHESION PROTEIN 2 (Eremotheciumgossypii) |
PF12765(Cohesin_HEAT)PF12830(Nipped-B_C) | 5 | TYR A 795ILE A 800VAL A 796TYR A 758ILE A 782 | None | 1.41A | 5u98D-5me3A:undetectable | 5u98D-5me3A:12.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mu7 | COATOMER SUBUNITDELTA-LIKE PROTEIN (Chaetomiumthermophilum) |
PF01217(Clat_adaptor_s) | 5 | TYR B 58ILE B 69VAL B 67TYR B 65SER B 7 | None | 0.98A | 5u98D-5mu7B:undetectable | 5u98D-5mu7B:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5sv9 | BOR1P BORONTRANSPORTER (Saccharomycesmikatae) |
PF00955(HCO3_cotransp) | 5 | VAL A 312TYR A 307ASP A 309SER A 313ILE A 356 | None | 1.27A | 5u98D-5sv9A:undetectable | 5u98D-5sv9A:17.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tta | PUTATIVE EXPORTEDPROTEIN (Clostridioidesdifficile) |
no annotation | 5 | TYR A 252ILE A 103SER A 234ILE A 232TRP A 119 | None | 1.41A | 5u98D-5ttaA:2.2 | 5u98D-5ttaA:18.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uam | ULVAN LYASE-PL25 (Pseudoalteromonassp. PLSV) |
PF15892(BNR_4) | 5 | TYR A 188ILE A 64TYR A 246ASP A 262ILE A 345 | EDO A 511 ( 3.0A) K A 505 (-4.0A)EDO A 511 ( 3.8A)NoneNone | 1.24A | 5u98D-5uamA:undetectable | 5u98D-5uamA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uwv | L,D-TRANSPEPTIDASE 2 (Mycobacteroidesabscessus) |
no annotation | 5 | TYR B 289ILE B 291VAL B 372SER B 252ILE B 263 | None | 0.98A | 5u98D-5uwvB:3.9 | 5u98D-5uwvB:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vyw | PYRUVATE CARBOXYLASE (Lactococcuslactis) |
PF00289(Biotin_carb_N)PF00682(HMGL-like)PF02436(PYC_OADA)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 5 | TYR A 776ILE A 741TYR A 775TYR A 744ILE A 755 | None | 1.45A | 5u98D-5vywA:3.7 | 5u98D-5vywA:12.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wpk | 3-HYDROXY-3-METHYLGLUTARYL COENZYME AREDUCTASE (Streptococcuspneumoniae) |
no annotation | 5 | TYR A 73ILE A 357VAL A 66SER A 92ILE A 95 | None | 1.45A | 5u98D-5wpkA:undetectable | 5u98D-5wpkA:15.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5xmm | MHC CLASS I ANTIGENALPHA CHAIN (Felis catus) |
no annotation | 6 | TYR A 10ILE A 96TYR A 100TYR A 124ILE A 125TRP A 148 | None | 0.40A | 5u98D-5xmmA:34.0 | 5u98D-5xmmA:37.08 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6avf | HLA CLASS IHISTOCOMPATIBILITYANTIGEN, B-7 ALPHACHAIN (Homo sapiens) |
no annotation | 6 | TYR H 9TYR H 99ASP H 114TYR H 123ILE H 124TRP H 147 | None | 0.42A | 5u98D-6avfH:33.7 | 5u98D-6avfH:65.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6avo | PROTEASOME SUBUNITBETA TYPE-10 (Homo sapiens) |
no annotation | 5 | ILE B 37VAL B 100TYR B 111TYR B 42ILE B 178 | None | 1.27A | 5u98D-6avoB:undetectable | 5u98D-6avoB:13.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bfu | SPIKE PROTEIN (CoronavirusHKU15) |
no annotation | 5 | ILE A 573VAL A 571TYR A 567ASP A 568TYR A 967 | None | 1.25A | 5u98D-6bfuA:undetectable | 5u98D-6bfuA:13.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ces | RAS-RELATEDGTP-BINDING PROTEINC (Homo sapiens) |
no annotation | 5 | TYR C 142ILE C 141VAL C 143ASP C 145ILE C 77 | None | 1.41A | 5u98D-6cesC:undetectable | 5u98D-6cesC:15.73 |