SIMILAR PATTERNS OF AMINO ACIDS FOR 5U6N_B_SALB504_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1

(Caenorhabditis
elegans) 		PF00248
(Aldo_ket_red) 		4 SER A 197
GLN A 175
MET A  16
THR A  79
 None
 1.33A 5u6nB-1qwkA:
2.7		 5u6nB-1qwkA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp7 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		4 SER A 270
PHE A 247
MET A 154
THR A 292
 None
 1.18A 5u6nB-1tp7A:
undetectable		 5u6nB-1tp7A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btw ALR0975 PROTEIN

(Nostoc sp. PCC
7120) 		PF05023
(Phytochelatin) 		4 PHE A 236
GLN A 155
MET A 221
THR A 147
 None
 1.26A 5u6nB-2btwA:
undetectable		 5u6nB-2btwA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlz CEPHALOSPORIN
ACYLASE

(Bacillus
halodurans) 		PF01019
(G_glu_transpept) 		4 SER A  65
GLN A  30
MET A 439
THR A 532
 None
 1.45A 5u6nB-2nlzA:
undetectable		 5u6nB-2nlzA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xmo LMO2642 PROTEIN

(Listeria
monocytogenes) 		PF00149
(Metallophos) 		4 HIS A 311
PHE A 351
GLN A  73
THR A 358
 None
 1.21A 5u6nB-2xmoA:
1.2		 5u6nB-2xmoA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF13469
(Sulfotransfer_3) 		4 SER A 233
HIS A 295
PHE A 198
GLN A 291
 None
PLM  A 700 (-3.8A)
None
PLM  A 700 (-3.1A)
 1.48A 5u6nB-2z6vA:
undetectable		 5u6nB-2z6vA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay2 LIPID MODIFIED
AZURIN PROTEIN

(Neisseria
gonorrhoeae) 		PF00127
(Copper-bind) 		4 SER A  65
HIS A  91
GLN A  95
MET A 175
 None
None
None
ZN  A1001 (-3.5A)
 1.37A 5u6nB-3ay2A:
undetectable		 5u6nB-3ay2A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dv9 BETA-PHOSPHOGLUCOMUT
ASE

(Bacteroides
vulgatus) 		PF13419
(HAD_2) 		4 SER A 130
HIS A  38
PHE A  98
MET A  27
 None
 1.50A 5u6nB-3dv9A:
5.0		 5u6nB-3dv9A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwi CYSTEINE SYNTHASE B

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		4 SER A 160
HIS A 161
MET A  58
THR A  82
 None
 1.49A 5u6nB-3dwiA:
undetectable		 5u6nB-3dwiA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0i EPOXIDE HYDROLASE

(Aspergillus
niger) 		PF06441
(EHN) 		4 SER A 155
HIS A  97
PHE A 121
GLN A  86
 None
 1.29A 5u6nB-3g0iA:
2.7		 5u6nB-3g0iA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi6 ALPHA-GALACTOSIDASE

(Lactobacillus
brevis) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 SER A 653
PHE A 732
GLN A 730
THR A 680
 None
 1.33A 5u6nB-3mi6A:
undetectable		 5u6nB-3mi6A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnd POSSIBLE SUBSTRATE
BINDING PROTEIN OF
ABC TRANSPORTER
SYSTEM

(Rhodopseudomonas
palustris) 		no annotation 4 SER B 300
PHE B 293
GLN B 138
MET B 336
 None
 1.25A 5u6nB-3nndB:
4.0		 5u6nB-3nndB:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phg SHIKIMATE
DEHYDROGENASE

(Helicobacter
pylori) 		PF08501
(Shikimate_dh_N) 		4 SER A  18
HIS A  22
PHE A 245
THR A 104
 None
 1.38A 5u6nB-3phgA:
4.6		 5u6nB-3phgA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT L

(Escherichia
coli) 		no annotation 4 SER L 398
HIS L 334
GLN L 315
THR L 425
 None
 1.12A 5u6nB-3rkoL:
undetectable		 5u6nB-3rkoL:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwk INULINASE

(Aspergillus
ficuum) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 SER X 201
HIS X 194
MET X 190
THR X 126
 None
 1.21A 5u6nB-3rwkX:
undetectable		 5u6nB-3rwkX:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8x TRANSFERRIN-BINDING
PROTEIN 1

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 SER A 137
HIS A 403
PHE A 338
GLN A 336
 None
 1.34A 5u6nB-3v8xA:
undetectable		 5u6nB-3v8xA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccd GALACTOCEREBROSIDASE

(Mus musculus) 		PF02057
(Glyco_hydro_59)
PF17387
(Glyco_hydro_59M) 		4 SER A 530
HIS A 652
PHE A 583
THR A 591
 None
 1.37A 5u6nB-4ccdA:
undetectable		 5u6nB-4ccdA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt1 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4
R-SPONDIN-1

(Homo sapiens) 		PF01462
(LRRNT)
PF13516
(LRR_6)
PF13855
(LRR_8)
PF15913
(Furin-like_2) 		4 SER A 133
HIS A 157
PHE E 110
GLN A 180
 None
 1.46A 5u6nB-4kt1A:
undetectable		 5u6nB-4kt1A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nrh COPN

(Chlamydia
pneumoniae) 		PF07201
(HrpJ) 		4 SER A 143
HIS A 171
PHE A 175
GLN A 133
 None
 1.47A 5u6nB-4nrhA:
undetectable		 5u6nB-4nrhA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p4g SHIKIMATE
5-DEHYDROGENASE AROE
(5-DEHYDROSHIKIMATE
REDUCTASE)

(Mycobacterium
tuberculosis) 		PF08501
(Shikimate_dh_N) 		4 SER A  20
HIS A  24
PHE A 251
THR A 104
 SKM  A 301 (-2.6A)
None
None
None
 1.41A 5u6nB-4p4gA:
4.6		 5u6nB-4p4gA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8d SULFOXIDE SYNTHASE
EGTB

(Mycolicibacterium
thermoresistibile) 		PF03781
(FGE-sulfatase)
PF12867
(DinB_2) 		4 SER A 381
PHE A 412
GLN A 137
MET A 375
 None
None
AVI  A 502 (-3.1A)
None
 1.43A 5u6nB-4x8dA:
undetectable		 5u6nB-4x8dA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yv2 SPERMIDINE SYNTHASE,
PUTATIVE

(Trypanosoma
cruzi) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 SER A  84
HIS A 279
PHE A 283
THR A 244
 None
 1.29A 5u6nB-4yv2A:
3.9		 5u6nB-4yv2A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kh5 ISOPRENYL
TRANSFERASE

(Streptococcus
pneumoniae) 		PF01255
(Prenyltransf) 		4 PHE A  94
GLN A  53
MET A  27
THR A  56
 None
 1.25A 5u6nB-5kh5A:
4.3		 5u6nB-5kh5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 4 HIS B   6
PHE B  20
GLN B 136
THR B 239
 None
 1.45A 5u6nB-5n5nB:
4.3		 5u6nB-5n5nB:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oet GLUTATHIONE
SYNTHETASE-LIKE
EFFECTOR 30
(GPA-GSS30-APO)

(Globodera
pallida) 		no annotation 4 SER B 346
HIS B 347
PHE B 163
GLN B 165
 None
 1.19A 5u6nB-5oetB:
undetectable		 5u6nB-5oetB:
10.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2

(Arabidopsis
thaliana) 		PF00201
(UDPGT) 		5 HIS A  18
PHE A 113
GLN A 134
MET A 274
THR A 365
 7WV  A 504 (-4.6A)
7WV  A 504 (-4.8A)
7WV  A 504 (-3.0A)
7WV  A 504 ( 3.5A)
7WV  A 504 (-3.2A)
 0.25A 5u6nB-5u6sA:
67.7		 5u6nB-5u6sA:
99.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eon BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 SER A 317
HIS A 267
PHE A 265
THR A 721
 None
None
GLA  A 801 (-4.7A)
CA  A 802 (-3.6A)
 1.30A 5u6nB-6eonA:
2.1		 5u6nB-6eonA:
21.04