SIMILAR PATTERNS OF AMINO ACIDS FOR 5U6M_B_SALB503_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex0 COAGULATION FACTOR
XIII A CHAIN

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 THR A 558
HIS A 605
PHE A 607
THR A 365
 None
 1.28A 5u6mB-1ex0A:
undetectable		 5u6mB-1ex0A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gv3 MANGANESE SUPEROXIDE
DISMUTASE

(Nostoc sp. PCC
7120) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 THR A  58
HIS A  62
PHE A 120
MET A 124
 None
MN  A1238 (-3.4A)
None
None
 1.36A 5u6mB-1gv3A:
undetectable		 5u6mB-1gv3A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr9 MANGANESE SUPEROXIDE
DISMUTASE

(Virgibacillus
halodenitrificans) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 THR A  23
HIS A  27
PHE A  85
MET A  89
 None
MN  A 204 (-3.2A)
None
None
 1.41A 5u6mB-1jr9A:
undetectable		 5u6mB-1jr9A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js8 HEMOCYANIN

(Enteroctopus
dofleini) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 THR A2705
HIS A2702
PHE A2698
MET A2686
 None
CUO  A 888 (-3.3A)
None
None
 1.50A 5u6mB-1js8A:
undetectable		 5u6mB-1js8A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pem RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
ALPHA CHAIN

(Salmonella
enterica) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF08343
(RNR_N) 		4 THR A 617
HIS A  17
PHE A 102
THR A 110
 None
 1.35A 5u6mB-1pemA:
3.1		 5u6mB-1pemA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8w GLYCEROL DEHYDRATASE

(Clostridium
butyricum) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 THR A 396
PHE A 705
GLN A 703
MET A 787
 None
 1.13A 5u6mB-1r8wA:
undetectable		 5u6mB-1r8wA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa) 		PF16363
(GDP_Man_Dehyd) 		4 THR A   8
PHE A 121
GLN A 123
MET A  60
 None
None
None
NDP  A1501 (-4.8A)
 1.28A 5u6mB-1rpnA:
5.2		 5u6mB-1rpnA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1unf IRON SUPEROXIDE
DISMUTASE

(Vigna
unguiculata) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 THR X  39
HIS X  43
PHE X  98
MET X 102
 None
FE  X1239 (-3.3A)
None
None
 1.36A 5u6mB-1unfX:
undetectable		 5u6mB-1unfX:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btw ALR0975 PROTEIN

(Nostoc sp. PCC
7120) 		PF05023
(Phytochelatin) 		4 PHE A 236
GLN A 155
MET A 221
THR A 147
 None
 1.22A 5u6mB-2btwA:
undetectable		 5u6mB-2btwA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D

(Methanothermobacter
thermautotrophicus) 		PF00710
(Asparaginase) 		4 THR A 179
PHE A 199
MET A 148
THR A 156
 None
 1.19A 5u6mB-2d6fA:
3.2		 5u6mB-2d6fA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7z ACETYLENE HYDRATASE
AHY

(Pelobacter
acetylenicus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 THR A 449
PHE A 398
MET A 401
THR A 135
 None
 1.35A 5u6mB-2e7zA:
undetectable		 5u6mB-2e7zA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7z CONSERVED
HYPOTHETICAL PROTEIN
SPY1493

(Streptococcus
pyogenes) 		PF02645
(DegV) 		4 THR A 259
PHE A  49
MET A  53
THR A  62
 HXA  A9136 ( 3.7A)
None
None
GOL  A2647 ( 3.3A)
 1.44A 5u6mB-2g7zA:
2.2		 5u6mB-2g7zA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nox TRYPTOPHAN
2,3-DIOXYGENASE

(Cupriavidus
metallidurans) 		PF03301
(Trp_dioxygenase) 		4 HIS A  72
PHE A  68
MET A 133
THR A 271
 HEM  A 500 (-3.5A)
HEM  A 500 (-4.4A)
None
None
 1.28A 5u6mB-2noxA:
undetectable		 5u6mB-2noxA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qri H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN K-B ALPHA
CHAIN, BETA-2
MICROGLOBULIN,
OVALBUMIN-DERIVED
PEPTIDE

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 HIS A  31
PHE A  62
GLN A  96
MET A  54
 None
 1.16A 5u6mB-2qriA:
undetectable		 5u6mB-2qriA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		4 THR G1063
HIS G1055
MET G 597
THR G 813
 None
None
FMN  G3051 (-4.4A)
None
 1.13A 5u6mB-2uv8G:
undetectable		 5u6mB-2uv8G:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xmo LMO2642 PROTEIN

(Listeria
monocytogenes) 		PF00149
(Metallophos) 		4 HIS A 311
PHE A 351
GLN A  73
THR A 358
 None
 1.28A 5u6mB-2xmoA:
undetectable		 5u6mB-2xmoA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hum PENICILLIN-BINDING
PROTEIN 4

(Staphylococcus
aureus) 		PF00768
(Peptidase_S11)
PF09211
(DUF1958) 		4 THR A 260
HIS A 270
MET A 250
THR A 255
 CEW  A 501 ( 4.3A)
None
None
None
 1.37A 5u6mB-3humA:
undetectable		 5u6mB-3humA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5

(Homo sapiens) 		PF00443
(UCH)
PF00627
(UBA)
PF02148
(zf-UBP) 		4 THR A 367
HIS A  61
GLN A  67
THR A  15
 None
 1.44A 5u6mB-3ihpA:
undetectable		 5u6mB-3ihpA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyo QUINATE/SHIKIMATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF08501
(Shikimate_dh_N) 		4 THR A  19
HIS A  23
PHE A 266
THR A 109
 None
 1.36A 5u6mB-3jyoA:
3.5		 5u6mB-3jyoA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kky SUPEROXIDE DISMUTASE
[MN]

(Deinococcus
radiodurans) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 THR A  22
HIS A  26
PHE A  83
MET A  87
 None
MN  A 211 (-3.3A)
None
None
 1.35A 5u6mB-3kkyA:
undetectable		 5u6mB-3kkyA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN

(Legionella
pneumophila) 		PF13407
(Peripla_BP_4) 		4 THR A  87
HIS A  30
GLN A 158
THR A 215
 None
GOL  A 317 (-4.3A)
None
GOL  A 317 ( 4.7A)
 1.27A 5u6mB-3rotA:
4.4		 5u6mB-3rotA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sm3 SAM-DEPENDENT
METHYLTRANSFERASES

(Methanosarcina
mazei) 		PF08241
(Methyltransf_11) 		4 THR A 112
HIS A 184
PHE A 168
THR A 213
 None
 1.28A 5u6mB-3sm3A:
3.5		 5u6mB-3sm3A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae) 		PF00291
(PALP) 		4 THR A 181
HIS A 152
MET A 289
THR A  14
 PLP  A 401 (-3.6A)
PLP  A 401 ( 4.9A)
None
None
 1.37A 5u6mB-3x43A:
3.3		 5u6mB-3x43A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ars HISTIDINE ACID
PHOSPHATASE

(Hafnia alvei) 		PF00328
(His_Phos_2) 		4 PHE A 224
MET A 168
MET A  27
THR A  35
 None
 1.38A 5u6mB-4arsA:
undetectable		 5u6mB-4arsA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 THR A1049
HIS A1046
PHE A1042
MET A1030
 None
CUO  A9003 (-3.2A)
CUO  A9003 ( 4.9A)
None
 1.39A 5u6mB-4bedA:
undetectable		 5u6mB-4bedA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpp PROBABLE GLUTAMINE
SYNTHETASE

(Pseudomonas
aeruginosa) 		PF00120
(Gln-synt_C)
PF16952
(Gln-synt_N_2) 		4 THR A 339
GLN A  51
MET A 419
THR A 427
 None
 1.16A 5u6mB-4hppA:
undetectable		 5u6mB-4hppA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz2 SUPEROXIDE DISMUTASE

(Clostridioides
difficile) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 THR A  52
HIS A  56
PHE A 114
MET A 118
 None
CO  A 301 (-3.3A)
None
None
 1.37A 5u6mB-4jz2A:
undetectable		 5u6mB-4jz2A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rp8 ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA

(Escherichia
coli) 		PF03611
(EIIC-GAT) 		4 HIS A 194
GLN A 196
MET A 408
MET A 131
 ASC  A 501 (-4.1A)
None
None
None
 1.40A 5u6mB-4rp8A:
undetectable		 5u6mB-4rp8A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txg CHITINASE

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18)
PF06483
(ChiC) 		4 THR A 184
HIS A 185
PHE A 391
GLN A 365
 None
 1.48A 5u6mB-4txgA:
2.9		 5u6mB-4txgA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 THR A 209
PHE A 187
MET A 519
THR A 510
 None
 1.42A 5u6mB-4wboA:
undetectable		 5u6mB-4wboA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zbt ACETOACETATE
DECARBOXYLASE

(Streptomyces
bingchenggensis) 		PF06314
(ADC) 		4 THR A  27
HIS A 247
PHE A 149
THR A 140
 None
 1.36A 5u6mB-4zbtA:
undetectable		 5u6mB-4zbtA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkv ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)

(Agrobacterium
vitis) 		PF13407
(Peripla_BP_4) 		4 THR A 179
PHE A  46
MET A  50
THR A 307
 T6T  A 401 (-3.0A)
T6T  A 401 (-3.2A)
None
None
 1.48A 5u6mB-5dkvA:
5.6		 5u6mB-5dkvA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f84 O-GLUCOSYLTRANSFERAS
E RUMI

(Drosophila
melanogaster) 		PF05686
(Glyco_transf_90) 		4 THR A 193
PHE A 278
MET A 206
THR A 185
 UDP  A 501 ( 4.6A)
UDP  A 501 ( 3.3A)
SO4  A 502 (-3.7A)
None
 1.28A 5u6mB-5f84A:
6.9		 5u6mB-5f84A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irr SEPTIN-LIKE PROTEIN

(Chlamydomonas
reinhardtii) 		PF00735
(Septin) 		4 THR A 146
PHE A 151
GLN A 178
MET A 195
 MG  A 401 ( 3.2A)
None
None
None
 1.38A 5u6mB-5irrA:
4.5		 5u6mB-5irrA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kh5 ISOPRENYL
TRANSFERASE

(Streptococcus
pneumoniae) 		PF01255
(Prenyltransf) 		4 PHE A  94
GLN A  53
MET A  27
THR A  56
 None
 1.19A 5u6mB-5kh5A:
4.1		 5u6mB-5kh5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpq TRANSGLYCOSYLASE

(Neisseria
meningitidis) 		PF01464
(SLT)
PF14718
(SLT_L) 		4 THR A 506
HIS A 439
MET A 490
MET A 474
 None
 1.40A 5u6mB-5mpqA:
undetectable		 5u6mB-5mpqA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 4 HIS B   6
PHE B  20
GLN B 136
THR B 239
 None
 1.42A 5u6mB-5n5nB:
3.3		 5u6mB-5n5nB:
22.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2

(Arabidopsis
thaliana) 		PF00201
(UDPGT) 		7 THR A  15
HIS A  18
PHE A 113
GLN A 134
MET A 183
MET A 274
THR A 365
 7WV  A 504 (-3.7A)
7WV  A 504 (-4.6A)
7WV  A 504 (-4.8A)
7WV  A 504 (-3.0A)
None
7WV  A 504 ( 3.5A)
7WV  A 504 (-3.2A)
 0.31A 5u6mB-5u6sA:
66.8		 5u6mB-5u6sA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz5 PRE-MRNA-PROCESSING
FACTOR 39
U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42

(Saccharomyces
cerevisiae) 		no annotation 4 THR E 518
HIS E 519
GLN D 411
THR D 452
 None
 1.25A 5u6mB-5uz5E:
undetectable		 5u6mB-5uz5E:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwp ORF1AB

(Middle East
respiratory
syndrome-related
coronavirus) 		no annotation 4 THR B  37
HIS B  33
PHE B 106
THR B 137
 None
ZN  B 602 (-3.0A)
None
None
 1.05A 5u6mB-5wwpB:
undetectable		 5u6mB-5wwpB:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zov -

(-) 		no annotation 4 HIS A 194
GLN A 196
MET A 413
MET A 131
 ASC  A 501 (-4.0A)
None
None
None
 1.39A 5u6mB-5zovA:
undetectable		 5u6mB-5zovA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE DELTA
SUBUNIT
ATP SYNTHASE GAMMA
SUBUNIT

(Trypanosoma
brucei) 		no annotation 4 THR G  49
HIS G 220
PHE G 219
THR H  38
 None
 1.32A 5u6mB-6f5dG:
2.2		 5u6mB-6f5dG:
9.95