SIMILAR PATTERNS OF AMINO ACIDS FOR 5U6M_A_SALA503

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gv3 MANGANESE SUPEROXIDE
DISMUTASE

(Nostoc sp. PCC
7120) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 THR A  58
HIS A  62
PHE A 120
MET A 124
 None
MN  A1238 (-3.4A)
None
None
 1.37A 5u6mA-1gv3A:
undetectable		 5u6mA-1gv3A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1e MYCOLIC ACID
SYNTHASE

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		4 THR A 154
PHE A 142
MET A 164
THR A 168
 None
SAH  A 900 ( 4.7A)
None
None
 1.36A 5u6mA-1l1eA:
2.2		 5u6mA-1l1eA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pem RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
ALPHA CHAIN

(Salmonella
enterica) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF08343
(RNR_N) 		4 THR A 617
HIS A  17
PHE A 102
THR A 110
 None
 1.33A 5u6mA-1pemA:
3.0		 5u6mA-1pemA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8w GLYCEROL DEHYDRATASE

(Clostridium
butyricum) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 THR A 396
PHE A 705
GLN A 703
MET A 787
 None
 0.96A 5u6mA-1r8wA:
2.4		 5u6mA-1r8wA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u1h 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Arabidopsis
thaliana) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 THR A 326
HIS A   4
MET A  49
THR A  61
 None
 1.47A 5u6mA-1u1hA:
2.3		 5u6mA-1u1hA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1unf IRON SUPEROXIDE
DISMUTASE

(Vigna
unguiculata) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 THR X  39
HIS X  43
PHE X  98
MET X 102
 None
FE  X1239 (-3.3A)
None
None
 1.37A 5u6mA-1unfX:
undetectable		 5u6mA-1unfX:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btw ALR0975 PROTEIN

(Nostoc sp. PCC
7120) 		PF05023
(Phytochelatin) 		4 PHE A 236
GLN A 155
MET A 221
THR A 147
 None
 1.09A 5u6mA-2btwA:
undetectable		 5u6mA-2btwA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7z CONSERVED
HYPOTHETICAL PROTEIN
SPY1493

(Streptococcus
pyogenes) 		PF02645
(DegV) 		4 THR A 259
PHE A  49
MET A  53
THR A  62
 HXA  A9136 ( 3.7A)
None
None
GOL  A2647 ( 3.3A)
 1.42A 5u6mA-2g7zA:
3.1		 5u6mA-2g7zA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inp PHENOL HYDROXYLASE
COMPONENT PHN

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS) 		4 THR A 222
PHE A 210
MET A 279
MET A 149
 None
 1.04A 5u6mA-2inpA:
undetectable		 5u6mA-2inpA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qri H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN K-B ALPHA
CHAIN, BETA-2
MICROGLOBULIN,
OVALBUMIN-DERIVED
PEPTIDE

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 HIS A  31
PHE A  62
GLN A  96
MET A  54
 None
 1.26A 5u6mA-2qriA:
undetectable		 5u6mA-2qriA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		4 THR G1063
HIS G1055
MET G 597
THR G 813
 None
None
FMN  G3051 (-4.4A)
None
 1.13A 5u6mA-2uv8G:
0.1		 5u6mA-2uv8G:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vad RED FLUORESCENT
PROTEIN

(Discosoma sp.) 		PF01353
(GFP) 		4 THR A 179
PHE A  91
GLN A 109
MET A  83
 None
None
CRQ  A  66 ( 4.0A)
CL  A1227 (-4.6A)
 1.43A 5u6mA-2vadA:
undetectable		 5u6mA-2vadA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xmo LMO2642 PROTEIN

(Listeria
monocytogenes) 		PF00149
(Metallophos) 		4 HIS A 311
PHE A 351
GLN A  73
THR A 358
 None
 1.18A 5u6mA-2xmoA:
undetectable		 5u6mA-2xmoA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7d 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME

(Candidatus
Cloacimonas
acidaminovorans) 		PF05853
(BKACE) 		4 THR A 201
GLN A 170
MET A 104
THR A   7
 None
 1.26A 5u6mA-2y7dA:
2.9		 5u6mA-2y7dA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e5m NMRA-LIKE FAMILY
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF05368
(NmrA) 		4 THR A  79
PHE A 140
MET A 147
THR A  75
 None
 1.12A 5u6mA-3e5mA:
6.3		 5u6mA-3e5mA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp6 PROTEIN PAGP

(Escherichia
coli) 		PF07017
(PagP) 		4 THR A 141
PHE A  74
MET A  72
THR A 112
 SDS  A 163 ( 4.4A)
SO4  A 181 ( 4.8A)
SDS  A 163 (-4.6A)
SDS  A 163 ( 4.2A)
 1.18A 5u6mA-3gp6A:
undetectable		 5u6mA-3gp6A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gve YFKN PROTEIN

(Bacillus
subtilis) 		PF00149
(Metallophos) 		4 HIS A  87
GLN A  76
MET A  21
THR A 328
 None
 1.48A 5u6mA-3gveA:
undetectable		 5u6mA-3gveA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hnr PROBABLE
METHYLTRANSFERASE
BT9727_4108

(Bacillus
thuringiensis) 		PF08241
(Methyltransf_11) 		4 THR A 179
PHE A 197
GLN A 185
MET A 207
 None
 1.32A 5u6mA-3hnrA:
3.4		 5u6mA-3hnrA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyo QUINATE/SHIKIMATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF08501
(Shikimate_dh_N) 		4 THR A  19
HIS A  23
PHE A 266
THR A 109
 None
 1.30A 5u6mA-3jyoA:
undetectable		 5u6mA-3jyoA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kky SUPEROXIDE DISMUTASE
[MN]

(Deinococcus
radiodurans) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 THR A  22
HIS A  26
PHE A  83
MET A  87
 None
MN  A 211 (-3.3A)
None
None
 1.37A 5u6mA-3kkyA:
undetectable		 5u6mA-3kkyA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnd POSSIBLE SUBSTRATE
BINDING PROTEIN OF
ABC TRANSPORTER
SYSTEM

(Rhodopseudomonas
palustris) 		no annotation 4 THR B  34
PHE B 293
GLN B 138
THR B 132
 None
 1.42A 5u6mA-3nndB:
4.1		 5u6mA-3nndB:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pt5 NANS (YJHS), A
9-O-ACETYL
N-ACETYLNEURAMINIC
ACID ESTERASE

(Escherichia
coli) 		PF03629
(SASA) 		4 THR A 295
PHE A 182
GLN A  18
MET A 185
 None
 1.45A 5u6mA-3pt5A:
4.0		 5u6mA-3pt5A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		PF06824
(Glyco_hydro_125) 		4 PHE A 232
GLN A 141
MET A 414
THR A  65
 None
 1.26A 5u6mA-3qpfA:
undetectable		 5u6mA-3qpfA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sm3 SAM-DEPENDENT
METHYLTRANSFERASES

(Methanosarcina
mazei) 		PF08241
(Methyltransf_11) 		4 THR A 112
HIS A 184
PHE A 168
THR A 213
 None
 1.14A 5u6mA-3sm3A:
2.4		 5u6mA-3sm3A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tpu 42F3 ALPHA
42F3 BETA

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set)
PF09291
(DUF1968) 		4 THR B 135
PHE A 170
GLN A 116
MET A 165
 None
 1.42A 5u6mA-3tpuB:
undetectable		 5u6mA-3tpuB:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vte TETRAHYDROCANNABINOL
IC ACID SYNTHASE

(Cannabis sativa) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 THR A 291
PHE A 273
GLN A 277
MET A 397
 None
 1.25A 5u6mA-3vteA:
undetectable		 5u6mA-3vteA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpp PROBABLE GLUTAMINE
SYNTHETASE

(Pseudomonas
aeruginosa) 		PF00120
(Gln-synt_C)
PF16952
(Gln-synt_N_2) 		4 THR A 339
GLN A  51
MET A 419
THR A 427
 None
 1.17A 5u6mA-4hppA:
undetectable		 5u6mA-4hppA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz2 SUPEROXIDE DISMUTASE

(Clostridioides
difficile) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 THR A  52
HIS A  56
PHE A 114
MET A 118
 None
CO  A 301 (-3.3A)
None
None
 1.38A 5u6mA-4jz2A:
undetectable		 5u6mA-4jz2A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nap EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7

(Desulfovibrio
alaskensis) 		PF03480
(DctP) 		4 THR A  45
PHE A 238
MET A 219
THR A 211
 DTR  A 401 ( 3.7A)
DTR  A 401 (-4.7A)
DTR  A 401 ( 4.7A)
DTR  A 401 (-3.0A)
 1.41A 5u6mA-4napA:
undetectable		 5u6mA-4napA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nx1 C4-DICARBOXYLATE
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN

(Sulfitobacter
sp. NAS-14.1) 		PF03480
(DctP) 		4 PHE A 297
MET A 303
MET A 172
THR A 188
 None
 1.30A 5u6mA-4nx1A:
undetectable		 5u6mA-4nx1A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nx1 C4-DICARBOXYLATE
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN

(Sulfitobacter
sp. NAS-14.1) 		PF03480
(DctP) 		4 THR A 233
HIS A 235
MET A 172
MET A 303
 None
 1.23A 5u6mA-4nx1A:
undetectable		 5u6mA-4nx1A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opm LIPASE

(Acinetobacter
baumannii) 		PF12697
(Abhydrolase_6) 		4 THR A 205
PHE A 198
MET A 224
MET A 299
 15P  A 401 ( 4.5A)
15P  A 401 (-4.8A)
15P  A 401 ( 4.6A)
15P  A 401 ( 4.0A)
 1.05A 5u6mA-4opmA:
5.2		 5u6mA-4opmA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 THR A 209
PHE A 187
MET A 519
THR A 510
 None
 1.36A 5u6mA-4wboA:
undetectable		 5u6mA-4wboA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmd ORF1A

(Middle East
respiratory
syndrome-related
coronavirus) 		PF05409
(Peptidase_C30) 		4 PHE A 188
GLN A 197
MET A 133
THR A 174
 None
 1.15A 5u6mA-4wmdA:
undetectable		 5u6mA-4wmdA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkv ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)

(Agrobacterium
vitis) 		PF13407
(Peripla_BP_4) 		4 THR A 179
PHE A  46
MET A  50
THR A 307
 T6T  A 401 (-3.0A)
T6T  A 401 (-3.2A)
None
None
 1.42A 5u6mA-5dkvA:
5.3		 5u6mA-5dkvA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f84 O-GLUCOSYLTRANSFERAS
E RUMI

(Drosophila
melanogaster) 		PF05686
(Glyco_transf_90) 		4 THR A 193
PHE A 278
MET A 206
THR A 185
 UDP  A 501 ( 4.6A)
UDP  A 501 ( 3.3A)
SO4  A 502 (-3.7A)
None
 1.24A 5u6mA-5f84A:
7.2		 5u6mA-5f84A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fku DNA POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF01336
(tRNA_anti-codon)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 THR A 432
PHE A 556
GLN A 429
MET A 408
 None
 1.14A 5u6mA-5fkuA:
undetectable		 5u6mA-5fkuA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kh5 ISOPRENYL
TRANSFERASE

(Streptococcus
pneumoniae) 		PF01255
(Prenyltransf) 		4 PHE A  94
GLN A  53
MET A  27
THR A  56
 None
 1.21A 5u6mA-5kh5A:
3.5		 5u6mA-5kh5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpq TRANSGLYCOSYLASE

(Neisseria
meningitidis) 		PF01464
(SLT)
PF14718
(SLT_L) 		4 THR A 506
HIS A 439
MET A 490
MET A 474
 None
 1.28A 5u6mA-5mpqA:
undetectable		 5u6mA-5mpqA:
20.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2

(Arabidopsis
thaliana) 		PF00201
(UDPGT) 		7 THR A  15
HIS A  18
PHE A 113
GLN A 134
MET A 183
MET A 274
THR A 365
 7WV  A 504 (-3.7A)
7WV  A 504 (-4.6A)
7WV  A 504 (-4.8A)
7WV  A 504 (-3.0A)
None
7WV  A 504 ( 3.5A)
7WV  A 504 (-3.2A)
 0.38A 5u6mA-5u6sA:
65.4		 5u6mA-5u6sA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz5 PRE-MRNA-PROCESSING
FACTOR 39
U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42

(Saccharomyces
cerevisiae) 		no annotation 4 THR E 518
HIS E 519
GLN D 411
THR D 452
 None
 1.27A 5u6mA-5uz5E:
undetectable		 5u6mA-5uz5E:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwp ORF1AB

(Middle East
respiratory
syndrome-related
coronavirus) 		no annotation 4 THR B  37
HIS B  33
PHE B 106
THR B 137
 None
ZN  B 602 (-3.0A)
None
None
 1.04A 5u6mA-5wwpB:
undetectable		 5u6mA-5wwpB:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zov -

(-) 		no annotation 4 HIS A 194
GLN A 196
MET A 413
MET A 131
 ASC  A 501 (-4.0A)
None
None
None
 1.47A 5u6mA-5zovA:
undetectable		 5u6mA-5zovA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE

(Salmonella
enterica) 		no annotation 4 THR A 281
HIS A 444
MET A 153
THR A 223
 None
 1.29A 5u6mA-6c43A:
5.5		 5u6mA-6c43A:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE DELTA
SUBUNIT
ATP SYNTHASE GAMMA
SUBUNIT

(Trypanosoma
brucei) 		no annotation 4 THR G  49
HIS G 220
PHE G 219
THR H  38
 None
 1.31A 5u6mA-6f5dG:
undetectable		 5u6mA-6f5dG:
9.95