SIMILAR PATTERNS OF AMINO ACIDS FOR 5U63_B_ACTB405_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1glv GLUTATHIONE SYNTHASE

(Escherichia
coli) 		PF02951
(GSH-S_N)
PF02955
(GSH-S_ATP) 		3 GLY A   5
LEU A  80
HIS A  36
 None
 0.62A 5u63B-1glvA:
undetectable		 5u63B-1glvA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE

(Serratia
marcescens) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		3 GLY A 328
LEU A 399
HIS A 362
 BEZ  A1501 (-3.3A)
None
None
 0.68A 5u63B-1i7qA:
undetectable		 5u63B-1i7qA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khd ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Pectobacterium
carotovorum) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		3 GLY A 294
LEU A 289
HIS A 298
 None
 0.59A 5u63B-1khdA:
3.2		 5u63B-1khdA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m22 PEPTIDE AMIDASE

(Stenotrophomonas
maltophilia) 		PF01425
(Amidase) 		3 GLY A 113
LEU A 111
HIS A 116
 None
 0.63A 5u63B-1m22A:
undetectable		 5u63B-1m22A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxj PROBABLE
S-ADENOSYLMETHIONINE
:2-DEMETHYLMENAQUINO
NE METHYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF03737
(RraA-like) 		3 GLY A  97
LEU A 115
HIS A  96
 None
 0.66A 5u63B-1nxjA:
undetectable		 5u63B-1nxjA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9m INTERLEUKIN-6
RECEPTOR BETA CHAIN

(Homo sapiens) 		PF00041
(fn3)
PF06328
(Lep_receptor_Ig)
PF09240
(IL6Ra-bind) 		3 GLY A 101
LEU A  75
HIS A 131
 None
 0.61A 5u63B-1p9mA:
undetectable		 5u63B-1p9mA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
40 KDA SUBUNIT

(Paracoccus
denitrificans) 		no annotation 3 GLY B 196
LEU B 226
HIS B 192
 None
 0.49A 5u63B-1pbyB:
undetectable		 5u63B-1pbyB:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgu ACTIN INTERACTING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		3 GLY A 437
LEU A 432
HIS A 403
 None
 0.68A 5u63B-1pguA:
undetectable		 5u63B-1pguA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs0 2-OXOISOVALERATE
DEHYDROGENASE
ALPHA-SUBUNIT

(Pseudomonas
putida) 		PF00676
(E1_dh)
PF12573
(OxoDH_E1alpha_N) 		3 GLY A  62
LEU A  58
HIS A 342
 None
 0.55A 5u63B-1qs0A:
undetectable		 5u63B-1qs0A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s58 B19 PARVOVIRUS
CAPSID

(Primate
erythroparvovirus
1) 		PF00740
(Parvo_coat) 		3 GLY A 372
LEU A 544
HIS A 354
 None
 0.65A 5u63B-1s58A:
undetectable		 5u63B-1s58A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE

(Thermotoga
maritima) 		PF01634
(HisG) 		3 GLY E  64
LEU E  68
HIS E 172
 None
None
HIS  E1205 (-3.4A)
 0.57A 5u63B-1usyE:
undetectable		 5u63B-1usyE:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1k VANILLYL-ALCOHOL
OXIDASE

(Penicillium
simplicissimum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		3 GLY A 107
LEU A 423
HIS A 506
 None
 0.68A 5u63B-1w1kA:
undetectable		 5u63B-1w1kA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3t HYPOTHETICAL PROTEIN
YXAG

(Bacillus
subtilis) 		PF07883
(Cupin_2) 		3 GLY A 293
LEU A 294
HIS A 239
 None
 0.51A 5u63B-1y3tA:
undetectable		 5u63B-1y3tA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Entamoeba
histolytica) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLY A 263
LEU A 161
HIS A 291
 None
 0.63A 5u63B-1y9aA:
undetectable		 5u63B-1y9aA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP3 CORE
PROTEIN)

(Bluetongue
virus) 		PF01700
(Orbi_VP3) 		3 GLY A 374
LEU A 402
HIS A 378
 None
 0.59A 5u63B-2btvA:
undetectable		 5u63B-2btvA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Thermus
thermophilus) 		PF00202
(Aminotran_3) 		3 GLY A 146
LEU A 151
HIS A 145
 PMP  A1001 ( 4.1A)
None
None
 0.70A 5u63B-2e7uA:
undetectable		 5u63B-2e7uA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 GLY A 329
LEU A 330
HIS A  23
 None
 0.69A 5u63B-2eq9A:
26.9		 5u63B-2eq9A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fb5 HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN

(Bacillus cereus) 		PF02457
(DisA_N)
PF10372
(YojJ) 		3 GLY A 165
LEU A 164
HIS A 168
 None
 0.67A 5u63B-2fb5A:
undetectable		 5u63B-2fb5A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 GLY A 436
LEU A 353
HIS A 443
 None
None
CU  A 601 (-3.2A)
 0.60A 5u63B-2fqdA:
undetectable		 5u63B-2fqdA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk4 CONSERVED
HYPOTHETICAL PROTEIN

(Streptococcus
pneumoniae) 		PF04127
(DFP) 		3 GLY A  26
LEU A  52
HIS A  27
 None
 0.67A 5u63B-2gk4A:
4.3		 5u63B-2gk4A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtl HEMOGLOBIN LINKER
CHAIN L1

(Lumbricus
terrestris) 		PF00057
(Ldl_recept_a)
PF16915
(Eryth_link_C) 		3 GLY M 113
LEU M 114
HIS M 127
 None
 0.65A 5u63B-2gtlM:
undetectable		 5u63B-2gtlM:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwg 4-OXALOMESACONATE
HYDRATASE

(Rhodopseudomonas
palustris) 		PF04909
(Amidohydro_2) 		3 GLY A 226
LEU A 195
HIS A 223
 None
 0.54A 5u63B-2gwgA:
undetectable		 5u63B-2gwgA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2itb TRNA-(MS(2)IO(6)A)-H
YDROXYLASE, PUTATIVE

(Pseudomonas
putida) 		PF06175
(MiaE) 		3 GLY A 146
LEU A 148
HIS A 145
 None
 0.65A 5u63B-2itbA:
undetectable		 5u63B-2itbA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kb3 OXOGLUTARATE
DEHYDROGENASE
INHIBITOR

(Corynebacterium
glutamicum) 		PF00498
(FHA) 		3 GLY A 105
LEU A 107
HIS A  89
 None
TPO  A  15 ( 2.5A)
None
 0.60A 5u63B-2kb3A:
undetectable		 5u63B-2kb3A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kl2 AIG2-LIKE
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF06094
(GGACT) 		3 GLY A 140
LEU A 141
HIS A 139
 None
 0.62A 5u63B-2kl2A:
undetectable		 5u63B-2kl2A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2msv MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo sapiens) 		no annotation 3 GLY A  32
LEU A  36
HIS A  15
 None
 0.58A 5u63B-2msvA:
undetectable		 5u63B-2msvA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2om5 CONTACTIN 2

(Homo sapiens) 		PF07679
(I-set)
PF13927
(Ig_3) 		3 GLY A 133
LEU A 134
HIS A 130
 None
 0.67A 5u63B-2om5A:
undetectable		 5u63B-2om5A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtn NICOTINATE
(NICOTINAMIDE)
NUCLEOTIDE
ADENYLYLTRANSFERASE

(Bacillus
anthracis) 		PF01467
(CTP_transf_like) 		3 GLY A   5
LEU A  31
HIS A 102
 None
 0.68A 5u63B-2qtnA:
undetectable		 5u63B-2qtnA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00583
(Acetyltransf_1)
PF00696
(AA_kinase) 		3 GLY A  32
LEU A  35
HIS A  61
 None
 0.44A 5u63B-2r98A:
undetectable		 5u63B-2r98A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vw8 PA1000

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		3 GLY A 146
LEU A  29
HIS A 149
 None
 0.58A 5u63B-2vw8A:
undetectable		 5u63B-2vw8A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk8 CAI-1 AUTOINDUCER
SYNTHASE

(Vibrio cholerae) 		PF00155
(Aminotran_1_2) 		3 GLY A 216
LEU A 217
HIS A 210
 None
 0.56A 5u63B-2wk8A:
undetectable		 5u63B-2wk8A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x9p PIMD PROTEIN

(Streptomyces
natalensis) 		PF00067
(p450) 		3 GLY A 340
LEU A 337
HIS A 341
 HEM  A1398 (-4.1A)
None
None
 0.69A 5u63B-2x9pA:
undetectable		 5u63B-2x9pA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypf AVRBS3

(Xanthomonas
campestris) 		PF03377
(TAL_effector) 		3 GLY A 730
LEU A 731
HIS A 729
 None
 0.70A 5u63B-2ypfA:
undetectable		 5u63B-2ypfA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Bacillus
subtilis) 		PF00202
(Aminotran_3) 		3 GLY A 147
LEU A 152
HIS A 146
 PMP  A 431 ( 3.7A)
None
None
 0.63A 5u63B-3bs8A:
1.7		 5u63B-3bs8A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD

(Chromobacterium
violaceum) 		no annotation 3 GLY A 125
LEU A 127
HIS A 124
 None
 0.67A 5u63B-3c4aA:
8.5		 5u63B-3c4aA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80

(Kluyveromyces
lactis) 		PF01408
(GFO_IDH_MocA) 		3 GLY A 153
LEU A 151
HIS A 214
 None
 0.67A 5u63B-3e1kA:
3.3		 5u63B-3e1kA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec1 YQEH GTPASE

(Geobacillus
stearothermophilus) 		PF01926
(MMR_HSR1) 		3 GLY A 262
LEU A 307
HIS A 288
 None
 0.68A 5u63B-3ec1A:
undetectable		 5u63B-3ec1A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fh2 PROBABLE
ATP-DEPENDENT
PROTEASE (HEAT SHOCK
PROTEIN)

(Corynebacterium
glutamicum) 		PF02861
(Clp_N) 		3 GLY A  36
LEU A  15
HIS A  39
 None
 0.62A 5u63B-3fh2A:
undetectable		 5u63B-3fh2A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Entamoeba
histolytica;
Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLY A 263
LEU A 161
HIS A 291
 None
 0.68A 5u63B-3fpcA:
4.3		 5u63B-3fpcA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Clostridium
acetobutylicum) 		PF00155
(Aminotran_1_2) 		3 GLY A 159
LEU A 160
HIS A 296
 None
 0.41A 5u63B-3ftbA:
2.1		 5u63B-3ftbA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2i ESTERASE

(Xanthomonas
oryzae) 		PF03583
(LIP) 		3 GLY A 127
LEU A 128
HIS A 136
 None
 0.48A 5u63B-3h2iA:
1.7		 5u63B-3h2iA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib3 COCE/NOND FAMILY
HYDROLASE

(Staphylococcus
aureus) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		3 GLY A 206
LEU A 457
HIS A 476
 None
 0.67A 5u63B-3ib3A:
undetectable		 5u63B-3ib3A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3i CAPSID PROTEIN

(Penicillium
chrysogenum
virus) 		no annotation 3 GLY A 468
LEU A 471
HIS A 462
 None
 0.69A 5u63B-3j3iA:
undetectable		 5u63B-3j3iA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF10

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF16004
(EFTUD2) 		3 GLY B 219
LEU B 150
HIS B 220
 GDP  B1000 ( 4.7A)
None
None
 0.70A 5u63B-3jb9B:
undetectable		 5u63B-3jb9B:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k28 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
2

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		3 GLY A 147
LEU A 152
HIS A 146
 PLP  A 900 (-3.8A)
None
None
 0.67A 5u63B-3k28A:
1.7		 5u63B-3k28A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l01 GLGA GLYCOGEN
SYNTHASE

(Pyrococcus
abyssi) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		3 GLY A   7
LEU A  22
HIS A 127
 None
 0.68A 5u63B-3l01A:
undetectable		 5u63B-3l01A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7n PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		PF00117
(GATase) 		3 GLY A  54
LEU A  92
HIS A   8
 None
 0.68A 5u63B-3l7nA:
undetectable		 5u63B-3l7nA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lot UNCHARACTERIZED
PROTEIN

(Archaeoglobus
fulgidus) 		PF05853
(BKACE) 		3 GLY A 237
LEU A 245
HIS A 202
 None
 0.61A 5u63B-3lotA:
undetectable		 5u63B-3lotA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lps TOPOISOMERASE IV
SUBUNIT B

(Xanthomonas
oryzae) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		3 GLY A 130
LEU A 133
HIS A 123
 None
 0.53A 5u63B-3lpsA:
undetectable		 5u63B-3lpsA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdn GLUTAMINE
AMINOTRANSFERASE
CLASS-II DOMAIN
PROTEIN

(Ruegeria
pomeroyi) 		PF13230
(GATase_4) 		3 GLY A  80
LEU A  81
HIS A   8
 None
 0.67A 5u63B-3mdnA:
undetectable		 5u63B-3mdnA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml0 PENICILLIN G
ACYLASE, ALPHA
SUBUNIT

(Alcaligenes
faecalis) 		PF01804
(Penicil_amidase) 		3 GLY A 172
LEU A 175
HIS A 167
 None
 0.55A 5u63B-3ml0A:
undetectable		 5u63B-3ml0A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtj HOMOSERINE
DEHYDROGENASE

(Thiobacillus
denitrificans) 		PF00742
(Homoserine_dh)
PF01842
(ACT)
PF03447
(NAD_binding_3) 		3 GLY A  81
LEU A  82
HIS A 105
 None
 0.68A 5u63B-3mtjA:
undetectable		 5u63B-3mtjA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2e SHIKIMATE KINASE

(Helicobacter
pylori) 		PF01202
(SKI) 		3 GLY A  92
LEU A  91
HIS A   3
 None
 0.56A 5u63B-3n2eA:
2.1		 5u63B-3n2eA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2t PUTATIVE
OXIDOREDUCTASE

(Gluconobacter
oxydans) 		PF00248
(Aldo_ket_red) 		3 GLY A  86
LEU A  87
HIS A 130
 None
 0.69A 5u63B-3n2tA:
undetectable		 5u63B-3n2tA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o65 PUTATIVE
ATAXIN-3-LIKE
PROTEIN

(Homo sapiens) 		PF02099
(Josephin) 		3 GLY A 128
LEU A 179
HIS A 130
 None
 0.64A 5u63B-3o65A:
undetectable		 5u63B-3o65A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr1 PHOSPHOLIPASE C-BETA
(PLC-BETA)

(Doryteuthis
pealeii) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		3 GLY A 437
LEU A 440
HIS A 433
 None
 0.67A 5u63B-3qr1A:
undetectable		 5u63B-3qr1A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		3 GLY A 207
LEU A  88
HIS A 175
 None
 0.70A 5u63B-3qt4A:
undetectable		 5u63B-3qt4A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd8 FUMARATE HYDRATASE
CLASS II

(Mycolicibacterium
smegmatis) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		3 GLY A 220
LEU A 219
HIS A 146
 None
 0.66A 5u63B-3rd8A:
undetectable		 5u63B-3rd8A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugm TAL EFFECTOR
AVRBS3/PTHA

(Xanthomonas
oryzae) 		PF03377
(TAL_effector) 		3 GLY A 593
LEU A 594
HIS A 592
 None
 0.62A 5u63B-3ugmA:
undetectable		 5u63B-3ugmA:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdb PROBABLE
ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT

(Mycobacterium
tuberculosis) 		PF02861
(Clp_N) 		3 GLY A  36
LEU A  15
HIS A  39
 None
 0.64A 5u63B-3wdbA:
undetectable		 5u63B-3wdbA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvr PGM1

(Streptomyces
cirratus) 		no annotation 3 GLY A 334
LEU A 315
HIS A 332
 None
 0.69A 5u63B-3wvrA:
undetectable		 5u63B-3wvrA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apb FUMARATE HYDRATASE
CLASS II

(Mycobacterium
tuberculosis) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		3 GLY A 222
LEU A 221
HIS A 148
 None
 0.70A 5u63B-4apbA:
undetectable		 5u63B-4apbA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezi UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 3 GLY A 146
LEU A 147
HIS A 155
 None
 0.46A 5u63B-4eziA:
undetectable		 5u63B-4eziA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqd NIKO PROTEIN

(Streptomyces
tendae) 		PF00275
(EPSP_synthase) 		3 GLY A 107
LEU A 109
HIS A 106
 None
None
SO4  A 501 (-4.1A)
 0.68A 5u63B-4fqdA:
undetectable		 5u63B-4fqdA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvf BETA-HEXOSAMINIDASE

(Salmonella
enterica) 		PF00933
(Glyco_hydro_3) 		3 GLY A  93
LEU A  96
HIS A  88
 None
 0.65A 5u63B-4gvfA:
undetectable		 5u63B-4gvfA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iox TRIPARTITE TERMINASE
SUBUNIT UL15

(Human
alphaherpesvirus
1) 		PF02499
(DNA_pack_C) 		3 GLY A 522
LEU A 708
HIS A 540
 None
 0.69A 5u63B-4ioxA:
undetectable		 5u63B-4ioxA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0r CRYPTOCHROME-1

(Mus musculus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 GLY A 250
LEU A 251
HIS A 224
 None
 0.41A 5u63B-4k0rA:
undetectable		 5u63B-4k0rA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Xanthomonas
oryzae) 		PF01156
(IU_nuc_hydro) 		3 GLY A 149
LEU A 148
HIS A 191
 None
 0.47A 5u63B-4kl0A:
2.2		 5u63B-4kl0A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldc DOUBLE C2-LIKE
DOMAIN-CONTAINING
PROTEIN BETA

(Rattus
norvegicus) 		PF00168
(C2) 		3 GLY A 344
LEU A 346
HIS A 343
 None
 0.65A 5u63B-4ldcA:
undetectable		 5u63B-4ldcA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh1 SORBOSE
DEHYDROGENASE

(Ketogulonicigenium
vulgare) 		PF13360
(PQQ_2) 		3 GLY A 134
LEU A 129
HIS A  90
 None
 0.65A 5u63B-4mh1A:
undetectable		 5u63B-4mh1A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nql AMSH-LIKE PROTEASE
SST2

(Schizosaccharomyces
pombe) 		PF01398
(JAB) 		3 GLY A 293
LEU A 334
HIS A 304
 None
 0.70A 5u63B-4nqlA:
undetectable		 5u63B-4nqlA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pne METHYLTRANSFERASE-LI
KE PROTEIN

(Saccharopolyspora
spinosa) 		PF08241
(Methyltransf_11) 		3 GLY A  43
LEU A  60
HIS A  41
 None
None
SAH  A 301 ( 3.6A)
 0.67A 5u63B-4pneA:
2.7		 5u63B-4pneA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmh LP04448P

(Drosophila
melanogaster) 		PF12348
(CLASP_N) 		3 GLY A1047
LEU A1006
HIS A1051
 None
 0.66A 5u63B-4qmhA:
undetectable		 5u63B-4qmhA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qri HYPOXANTHINE-GUANINE
-XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Leptospira
interrogans) 		PF00156
(Pribosyltran) 		3 GLY A 156
LEU A 168
HIS A 172
 None
 0.67A 5u63B-4qriA:
undetectable		 5u63B-4qriA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ric FANCONI-ASSOCIATED
NUCLEASE 1

(Homo sapiens) 		PF08774
(VRR_NUC) 		3 GLY A 741
LEU A 744
HIS A 985
 None
 0.52A 5u63B-4ricA:
undetectable		 5u63B-4ricA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqg PUTATIVE
DTDP-D-GLUCOSE 4
6-DEHYDRATASE

(Megavirus
chiliensis) 		PF02719
(Polysacc_synt_2) 		3 GLY A 256
LEU A 257
HIS A 198
 None
 0.52A 5u63B-4tqgA:
undetectable		 5u63B-4tqgA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txg CHITINASE

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18)
PF06483
(ChiC) 		3 GLY A 732
LEU A 730
HIS A 722
 None
 0.65A 5u63B-4txgA:
undetectable		 5u63B-4txgA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8h CRYPTOCHROME-2

(Mus musculus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 GLY A 268
LEU A 269
HIS A 242
 None
 0.58A 5u63B-4u8hA:
undetectable		 5u63B-4u8hA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		3 GLY A 183
LEU A 182
HIS A 115
 FAD  A 601 (-3.6A)
FAD  A 601 (-4.5A)
FAD  A 601 (-2.5A)
 0.65A 5u63B-4ud8A:
undetectable		 5u63B-4ud8A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bjx WLAL PROTEIN

(Campylobacter
jejuni) 		no annotation 3 GLY A 521
LEU A 522
HIS A 459
 None
 0.68A 5u63B-5bjxA:
4.0		 5u63B-5bjxA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cj5 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE

(Mycolicibacterium
thermoresistibile) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		3 GLY A  53
LEU A 113
HIS A  52
 None
 0.67A 5u63B-5cj5A:
undetectable		 5u63B-5cj5A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cww NUCLEOPORIN NUP82

(Chaetomium
thermophilum) 		no annotation 3 GLY B 435
LEU B 479
HIS B 506
 None
 0.66A 5u63B-5cwwB:
undetectable		 5u63B-5cwwB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6p PLEXIN-B2

(Mus musculus) 		PF08337
(Plexin_cytopl) 		3 GLY A1364
LEU A1366
HIS A1363
 None
 0.65A 5u63B-5e6pA:
undetectable		 5u63B-5e6pA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4i PHOSPHOLYASE

(Paenarthrobacter
aurescens) 		PF00202
(Aminotran_3) 		3 GLY A 211
LEU A 205
HIS A 210
 None
 0.68A 5u63B-5g4iA:
undetectable		 5u63B-5g4iA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gt2 PROBABLE
DEFERROCHELATASE/PER
OXIDASE YFEX

(Escherichia
coli) 		PF04261
(Dyp_perox) 		3 GLY A 246
LEU A 139
HIS A 245
 None
 0.62A 5u63B-5gt2A:
undetectable		 5u63B-5gt2A:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gt5 PECTATE LYASE

(Paenibacillus
sp. 0602) 		no annotation 3 GLY A  90
LEU A  86
HIS A 114
 None
 0.62A 5u63B-5gt5A:
undetectable		 5u63B-5gt5A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5d INNER MEMBRANE
PROTEIN YEJM

(Salmonella
enterica) 		PF00884
(Sulfatase)
PF11893
(DUF3413) 		3 GLY A 308
LEU A 309
HIS A 491
 None
 0.65A 5u63B-5i5dA:
undetectable		 5u63B-5i5dA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5h INNER MEMBRANE
PROTEIN YEJM

(Escherichia
coli) 		PF00884
(Sulfatase)
PF11893
(DUF3413) 		3 GLY A 308
LEU A 309
HIS A 491
 None
 0.65A 5u63B-5i5hA:
undetectable		 5u63B-5i5hA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz3 PREDICTED PROTEIN

(Physcomitrella
patens) 		PF00316
(FBPase) 		3 GLY B  81
LEU B  80
HIS B 249
 None
 0.68A 5u63B-5iz3B:
undetectable		 5u63B-5iz3B:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0l GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY

(Clostridioides
difficile) 		no annotation 3 GLY A 106
LEU A 108
HIS A 105
 None
 0.63A 5u63B-5n0lA:
undetectable		 5u63B-5n0lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nko RIBOSOME HIBERNATION
PROMOTION FACTOR

(Staphylococcus
aureus) 		PF16321
(Ribosom_S30AE_C) 		3 GLY A 157
LEU A 156
HIS A 158
 None
 0.66A 5u63B-5nkoA:
undetectable		 5u63B-5nkoA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5x CRYPTOCHROME-1

(Mus musculus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 GLY A 250
LEU A 251
HIS A 224
 None
 0.49A 5u63B-5t5xA:
undetectable		 5u63B-5t5xA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		3 GLY C 920
LEU C 923
HIS C 590
 None
 0.63A 5u63B-5tw1C:
undetectable		 5u63B-5tw1C:
14.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u63 THIOREDOXIN
REDUCTASE

(Haemophilus
influenzae) 		PF07992
(Pyr_redox_2) 		3 GLY A  37
LEU A  38
HIS A  84
 FAD  A 401 ( 3.1A)
ACT  A 405 ( 3.6A)
ACT  A 405 ( 3.9A)
 0.10A 5u63B-5u63A:
50.4		 5u63B-5u63A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uy3 ANTIBODY PGT144 FAB
HEAVY CHAIN

(Homo sapiens) 		no annotation 3 GLY H  94
LEU H 105
HIS H  35
 None
 0.57A 5u63B-5uy3H:
undetectable		 5u63B-5uy3H:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6t PLEXIN-D1

(Mus musculus) 		PF08337
(Plexin_cytopl) 		3 GLY A1454
LEU A1456
HIS A1453
 None
 0.66A 5u63B-5v6tA:
undetectable		 5u63B-5v6tA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Desulfovibrio
gigas) 		no annotation 3 GLY A 189
LEU A 386
HIS A 186
 None
 0.62A 5u63B-5xmjA:
14.6		 5u63B-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqo PCRGLX PROTEIN

(Penicillium
chrysogenum) 		no annotation 3 GLY A  47
LEU A  48
HIS A  92
 None
 0.60A 5u63B-5xqoA:
undetectable		 5u63B-5xqoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xst POLY [ADP-RIBOSE]
POLYMERASE 1

(Homo sapiens) 		no annotation 3 GLY A 266
LEU A 193
HIS A 285
 None
 0.69A 5u63B-5xstA:
undetectable		 5u63B-5xstA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH13 NADH
DEHYDROGENASE
SUBUNIT

(Pyrococcus
furiosus) 		no annotation 3 GLY M 159
LEU M 158
HIS M 172
 None
 0.69A 5u63B-6cfwM:
undetectable		 5u63B-6cfwM:
undetectable