SIMILAR PATTERNS OF AMINO ACIDS FOR 5U63_A_ACTA406

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a4e CATALASE A

(Saccharomyces
cerevisiae) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 HIS A  72
SER A  74
ARG A 125
 None
 0.99A 5u63A-1a4eA:
undetectable		 5u63A-1a4eA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9w CHO REDUCTASE

(Cricetulus
griseus) 		PF00248
(Aldo_ket_red) 		3 HIS A 187
SER A 210
ARG A 217
 None
NAP  A 350 (-2.4A)
None
 0.92A 5u63A-1c9wA:
undetectable		 5u63A-1c9wA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e43 ALPHA-AMYLASE

(Bacillus
amyloliquefaciens) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 HIS A 235
SER A 187
ARG A 123
 None
 0.98A 5u63A-1e43A:
undetectable		 5u63A-1e43A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htd ATROLYSIN C

(Crotalus atrox) 		PF01421
(Reprolysin) 		3 HIS A  92
SER A  91
ARG A  89
 None
 0.98A 5u63A-1htdA:
undetectable		 5u63A-1htdA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
PF09131
(Endotoxin_mid) 		3 HIS A 500
SER A 304
ARG A 424
 None
 0.98A 5u63A-1i5pA:
undetectable		 5u63A-1i5pA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE

(Pyrococcus
horikoshii) 		PF00291
(PALP) 		3 HIS A  80
SER A  81
ARG A 103
 None
SO4  A 701 (-2.3A)
None
 1.02A 5u63A-1j0aA:
4.0		 5u63A-1j0aA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jpu GLYCEROL
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00465
(Fe-ADH) 		3 HIS A 291
SER A 292
ARG A 298
 None
 0.96A 5u63A-1jpuA:
0.8		 5u63A-1jpuA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k5s PENICILLIN G ACYLASE
BETA SUBUNIT

(Escherichia
coli) 		PF01804
(Penicil_amidase) 		3 HIS B 546
SER B 535
ARG B 495
 None
 0.87A 5u63A-1k5sB:
undetectable		 5u63A-1k5sB:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		3 HIS A 312
SER A 331
ARG A 318
 None
 0.92A 5u63A-1k9aA:
undetectable		 5u63A-1k9aA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p15 PROTEIN-TYROSINE
PHOSPHATASE ALPHA

(Mus musculus) 		PF00102
(Y_phosphatase) 		3 HIS A 723
SER A 598
ARG A 555
 None
 0.91A 5u63A-1p15A:
undetectable		 5u63A-1p15A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p2z HEXON PROTEIN

(Human
mastadenovirus
C) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		3 HIS A 552
SER A 611
ARG A 559
 None
 0.99A 5u63A-1p2zA:
undetectable		 5u63A-1p2zA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5m PROSTAGLANDIN-E2
9-REDUCTASE

(Oryctolagus
cuniculus) 		PF00248
(Aldo_ket_red) 		3 HIS A 194
SER A 217
ARG A 223
 None
NDP  A1003 (-2.8A)
None
 0.84A 5u63A-1q5mA:
undetectable		 5u63A-1q5mA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkl COPROPORPHYRINOGEN
III OXIDASE

(Saccharomyces
cerevisiae) 		PF01218
(Coprogen_oxidas) 		3 HIS A 131
SER A 117
ARG A 135
 None
 1.03A 5u63A-1tklA:
undetectable		 5u63A-1tklA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u4q SPECTRIN ALPHA
CHAIN, BRAIN

(Gallus gallus) 		PF00435
(Spectrin) 		3 HIS A1948
SER A1874
ARG A1870
 None
 0.98A 5u63A-1u4qA:
undetectable		 5u63A-1u4qA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6z EXOPOLYPHOSPHATASE

(Escherichia
coli) 		PF02541
(Ppx-GppA) 		3 HIS A 384
SER A 385
ARG A 413
 None
None
SO4  A 707 ( 3.0A)
 1.01A 5u63A-1u6zA:
undetectable		 5u63A-1u6zA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1waq GROWTH/DIFFERENTIATI
ON FACTOR 5

(Homo sapiens) 		PF00019
(TGF_beta) 		3 HIS A  59
SER A  20
ARG A  18
 None
 0.74A 5u63A-1waqA:
undetectable		 5u63A-1waqA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wrm DUAL SPECIFICITY
PHOSPHATASE 22

(Homo sapiens) 		PF00782
(DSPc) 		3 HIS A  38
SER A  36
ARG A  21
 None
 0.92A 5u63A-1wrmA:
undetectable		 5u63A-1wrmA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbr CONSERVED
HYPOTHETICAL PROTEIN

(Porphyromonas
gingivalis) 		PF04371
(PAD_porph) 		3 HIS A 117
SER A  80
ARG A  24
 None
 1.04A 5u63A-1zbrA:
undetectable		 5u63A-1zbrA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwm PSATHYRELLA VELUTINA
LECTIN PVL

(Lacrymaria
velutina) 		PF13517
(VCBS) 		3 HIS A 227
SER A 225
ARG A 278
 SNG  A1406 ( 3.8A)
None
None
 0.82A 5u63A-2bwmA:
undetectable		 5u63A-2bwmA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3n GLUTATHIONE
S-TRANSFERASE THETA
1

(Homo sapiens) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		3 HIS A 162
SER A 164
ARG A  94
 None
 0.84A 5u63A-2c3nA:
undetectable		 5u63A-2c3nA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5t DIPEPTIDYL PEPTIDASE
4

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 HIS A 100
SER A 131
ARG A 147
 None
 1.02A 5u63A-2g5tA:
undetectable		 5u63A-2g5tA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtl EXTRACELLULAR
HEMOGLOBIN LINKER L2
SUBUNIT

(Lumbricus
terrestris) 		PF00057
(Ldl_recept_a)
PF16915
(Eryth_link_C) 		3 HIS N  45
SER N  48
ARG N 199
 None
 0.99A 5u63A-2gtlN:
undetectable		 5u63A-2gtlN:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9u CYTOSINE/GUANINE
DEAMINASE RELATED
PROTEIN

(Clostridium
acetobutylicum) 		PF01979
(Amidohydro_1) 		3 HIS A  73
SER A 228
ARG A 202
 FE  A 501 (-3.4A)
None
GUN  A 503 (-3.7A)
 0.97A 5u63A-2i9uA:
undetectable		 5u63A-2i9uA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipj ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		3 HIS A 194
SER A 217
ARG A 223
 None
NAP  A   1 (-2.8A)
None
 0.85A 5u63A-2ipjA:
undetectable		 5u63A-2ipjA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2is7 ALDOSE REDUCTASE

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		3 HIS A 187
SER A 210
ARG A 217
 None
NAP  A 316 (-2.7A)
None
 0.77A 5u63A-2is7A:
undetectable		 5u63A-2is7A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isa CATALASE

(Aliivibrio
salmonicida) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 HIS A 362
SER A 363
ARG A 366
 None
 0.93A 5u63A-2isaA:
undetectable		 5u63A-2isaA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jzc UDP-N-ACETYLGLUCOSAM
INE TRANSFERASE
SUBUNIT ALG13

(Saccharomyces
cerevisiae) 		PF04101
(Glyco_tran_28_C) 		3 HIS A 139
SER A 138
ARG A 216
 None
 0.98A 5u63A-2jzcA:
undetectable		 5u63A-2jzcA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nty EMB|CAB41934.1
RAC-LIKE GTP-BINDING
PROTEIN ARAC5

(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		PF03759
(PRONE)
PF00071
(Ras) 		3 HIS C 132
SER A 144
ARG A 142
 None
 0.94A 5u63A-2ntyC:
undetectable		 5u63A-2ntyC:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obe HEXON

(Human
mastadenovirus
E) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		3 HIS A 517
SER A 576
ARG A 524
 None
 1.01A 5u63A-2obeA:
undetectable		 5u63A-2obeA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		3 HIS A 459
SER A 478
ARG A 465
 None
MG  A 614 ( 4.1A)
ANP  A 615 (-4.2A)
 0.83A 5u63A-2ozoA:
undetectable		 5u63A-2ozoA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3e DIAMINOPIMELATE
DECARBOXYLASE

(Aquifex
aeolicus) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		3 HIS A 326
SER A 373
ARG A 282
 None
 1.03A 5u63A-2p3eA:
undetectable		 5u63A-2p3eA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf7 PYRUVATE CARBOXYLASE
PROTEIN

(Rhizobium etli) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 HIS A 749
SER A 782
ARG A 548
 ZN  A1157 (-3.3A)
None
KCX  A 718 ( 3.6A)
 0.96A 5u63A-2qf7A:
2.7		 5u63A-2qf7A:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7d RIBONUCLEASE II
FAMILY PROTEIN

(Deinococcus
radiodurans) 		PF00773
(RNB) 		3 HIS A 393
SER A 390
ARG A  60
 None
 0.80A 5u63A-2r7dA:
undetectable		 5u63A-2r7dA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE

(Streptococcus
sp.) 		PF01266
(DAO)
PF16901
(DAO_C) 		3 HIS A 259
SER A  60
ARG A 346
 FAD  A 609 (-4.6A)
FAD  A 609 (-4.2A)
FAD  A 609 (-4.4A)
 1.00A 5u63A-2rghA:
4.4		 5u63A-2rghA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		3 HIS A 555
SER A 575
ARG A 552
 None
 0.94A 5u63A-2uvfA:
undetectable		 5u63A-2uvfA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2weu TRYPTOPHAN
5-HALOGENASE

(Streptomyces
rugosporus) 		PF04820
(Trp_halogenase) 		3 HIS A 437
SER A 434
ARG A 429
 None
 0.65A 5u63A-2weuA:
3.3		 5u63A-2weuA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjf TYROSINE-PROTEIN
PHOSPHATASE CPSB

(Streptococcus
pneumoniae) 		no annotation 3 HIS A   5
SER A 198
ARG A 206
 MN  A1246 (-3.4A)
None
PO4  A1244 (-3.6A)
 0.99A 5u63A-2wjfA:
undetectable		 5u63A-2wjfA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Thermus
thermophilus) 		PF09488
(Osmo_MPGsynth) 		3 HIS A 115
SER A  86
ARG A  62
 None
 0.97A 5u63A-2wvlA:
1.4		 5u63A-2wvlA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9j LIPOPROTEIN PRGK

(Salmonella
enterica) 		PF01514
(YscJ_FliF) 		3 HIS Y 129
SER Y 149
ARG Y 127
 None
 0.99A 5u63A-2y9jY:
undetectable		 5u63A-2y9jY:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzs PUTATIVE
UNCHARACTERIZED
PROTEIN

(Aquifex
aeolicus) 		PF01867
(Cas_Cas1) 		3 HIS A  10
SER A   9
ARG A 260
 None
 0.92A 5u63A-2yzsA:
undetectable		 5u63A-2yzsA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b12 FLUOROACETATE
DEHALOGENASE

(Burkholderia
sp.) 		PF00561
(Abhydrolase_1) 		3 HIS A 117
SER A  84
ARG A  80
 None
 0.79A 5u63A-3b12A:
undetectable		 5u63A-3b12A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5h CERVICAL EMMPRIN

(Homo sapiens) 		PF13927
(Ig_3) 		3 HIS A 170
SER A 161
ARG A 166
 None
 0.80A 5u63A-3b5hA:
undetectable		 5u63A-3b5hA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg9 PYRUVATE
CARBOXYLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		3 HIS A 773
SER A 806
ARG A 571
 MN  A2001 (-3.8A)
None
MN  A2001 ( 4.7A)
 0.99A 5u63A-3bg9A:
undetectable		 5u63A-3bg9A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cav 3-OXO-5-BETA-STEROID
4-DEHYDROGENASE

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		3 HIS A 197
SER A 220
ARG A 226
 None
NAP  A 327 (-2.9A)
None
 1.03A 5u63A-3cavA:
undetectable		 5u63A-3cavA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3

(Saccharomyces
cerevisiae) 		PF03571
(Peptidase_M49) 		3 HIS A  53
SER A 181
ARG A 213
 None
 0.98A 5u63A-3cskA:
undetectable		 5u63A-3cskA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6b GLUTARYL-COA
DEHYDROGENASE

(Burkholderia
pseudomallei) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 HIS A 270
SER A 267
ARG A  87
 None
 0.81A 5u63A-3d6bA:
undetectable		 5u63A-3d6bA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 HIS A 312
SER A 331
ARG A 318
 None
 0.92A 5u63A-3d7uA:
undetectable		 5u63A-3d7uA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8j COPROPORPHYRINOGEN
III OXIDASE

(Leishmania
naiffi) 		PF01218
(Coprogen_oxidas) 		3 HIS A 107
SER A  93
ARG A 111
 ACT  A 302 (-3.0A)
None
None
 1.04A 5u63A-3e8jA:
undetectable		 5u63A-3e8jA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeg 2-ISOPROPYLMALATE
SYNTHASE

(Cytophaga
hutchinsonii) 		PF00682
(HMGL-like) 		3 HIS A 106
SER A 102
ARG A 145
 None
 0.99A 5u63A-3eegA:
undetectable		 5u63A-3eegA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gc3 BETA-ARRESTIN-1

(Bos taurus) 		PF00339
(Arrestin_N)
PF02752
(Arrestin_C) 		3 HIS A 210
SER A 302
ARG A 169
 None
 0.98A 5u63A-3gc3A:
undetectable		 5u63A-3gc3A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hka URONATE ISOMERASE

(Bacillus
halodurans) 		no annotation 3 HIS A  26
SER A 354
ARG A 357
 ZN  A 430 ( 3.3A)
None
FIX  A 428 (-3.9A)
 0.96A 5u63A-3hkaA:
undetectable		 5u63A-3hkaA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmb N-ACETYLMURAMOYL-L-A
LANINE AMIDASE XLYA

(Bacillus
subtilis) 		PF01510
(Amidase_2) 		3 HIS A  57
SER A  55
ARG A  16
 None
 0.89A 5u63A-3hmbA:
undetectable		 5u63A-3hmbA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htz ALANYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF01411
(tRNA-synt_2c) 		3 HIS A  86
SER A  84
ARG A 224
 None
 0.90A 5u63A-3htzA:
undetectable		 5u63A-3htzA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kt4 PKHD-TYPE
HYDROXYLASE TPA1

(Saccharomyces
cerevisiae) 		PF10637
(Ofd1_CTDD)
PF13661
(2OG-FeII_Oxy_4) 		3 HIS A 227
SER A 225
ARG A 166
 FE  A 701 (-3.4A)
None
None
 1.02A 5u63A-3kt4A:
undetectable		 5u63A-3kt4A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		3 HIS A 758
SER A 777
ARG A 764
 None
 1.03A 5u63A-3kulA:
undetectable		 5u63A-3kulA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr HYDROGENASE (NIFE)
SMALL SUBUNIT HYDA
NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Allochromatium
vinosum;
Allochromatium
vinosum) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C)
PF00374
(NiFeSe_Hases) 		3 HIS B1016
SER A  88
ARG B1039
 None
 0.94A 5u63A-3myrB:
undetectable		 5u63A-3myrB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3r ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B7

(Rattus
norvegicus) 		PF00248
(Aldo_ket_red) 		3 HIS A 188
SER A 211
ARG A 218
 None
NAP  A 317 (-3.4A)
None
 0.85A 5u63A-3o3rA:
undetectable		 5u63A-3o3rA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohu TRANSCRIPTION
REGULATOR PROTEIN
BACH2

(Homo sapiens) 		PF00651
(BTB) 		3 HIS A 119
SER A  59
ARG A 117
 None
 0.98A 5u63A-3ohuA:
undetectable		 5u63A-3ohuA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE

(Entamoeba
histolytica) 		PF00145
(DNA_methylase) 		3 HIS A 278
SER A 305
ARG A 167
 None
 0.98A 5u63A-3qv2A:
2.7		 5u63A-3qv2A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qy7 TYROSINE-PROTEIN
PHOSPHATASE YWQE

(Bacillus
subtilis) 		no annotation 3 HIS A   5
SER A 193
ARG A 201
 FE  A 264 (-3.3A)
None
PO4  A 266 (-2.7A)
 1.01A 5u63A-3qy7A:
undetectable		 5u63A-3qy7A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN

(Pseudomonas
putida) 		PF00775
(Dioxygenase_C)
PF12391
(PCDO_beta_N) 		3 HIS M 361
SER M 438
ARG M 440
 None
 0.78A 5u63A-3t63M:
undetectable		 5u63A-3t63M:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txm 26S PROTEASOME
REGULATORY COMPLEX
SUBUNIT P42B

(Drosophila
melanogaster) 		PF01399
(PCI) 		3 HIS A 178
SER A 174
ARG A 187
 None
 0.97A 5u63A-3txmA:
undetectable		 5u63A-3txmA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut3 PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Homo sapiens) 		PF00079
(Serpin) 		3 HIS A  10
SER A  13
ARG A 363
 None
 0.95A 5u63A-3ut3A:
undetectable		 5u63A-3ut3A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wp5 CDBFV

(Neocallimastix
patriciarum) 		PF00457
(Glyco_hydro_11) 		3 HIS A 195
SER A  65
ARG A  61
 None
 0.71A 5u63A-3wp5A:
undetectable		 5u63A-3wp5A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxy PUTATIVE
UNCHARACTERIZED
PROTEIN CSYB

(Aspergillus
oryzae) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 HIS A 310
SER A 346
ARG A 351
 None
 0.99A 5u63A-3wxyA:
undetectable		 5u63A-3wxyA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au2 SERPIN PEPTIDASE
INHIBITOR, CLADE H
(HEAT SHOCK PROTEIN
47), MEMBER 1,
(COLLAGEN BINDING
PROTEIN 1)

(Canis lupus) 		PF00079
(Serpin) 		3 HIS A 108
SER A 149
ARG A 339
 None
 0.97A 5u63A-4au2A:
undetectable		 5u63A-4au2A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 HIS A 214
SER A 233
ARG A 220
 None
30K  A1365 ( 3.7A)
None
 1.02A 5u63A-4aw5A:
undetectable		 5u63A-4aw5A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czt CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 23

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		3 HIS A 152
SER A 171
ARG A 183
 None
CPS  A1316 (-4.0A)
None
 0.96A 5u63A-4cztA:
undetectable		 5u63A-4cztA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		3 HIS A 681
SER A 700
ARG A 687
 None
GUI  A 901 (-3.1A)
None
 0.99A 5u63A-4e93A:
undetectable		 5u63A-4e93A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 HIS A 492
SER A 511
ARG A 498
 None
0SB  A 701 (-3.2A)
None
 0.97A 5u63A-4f4pA:
undetectable		 5u63A-4f4pA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		3 HIS A 492
SER A 511
ARG A 498
 None
MG  A 702 ( 4.2A)
ANP  A 701 (-4.2A)
 0.88A 5u63A-4fl3A:
undetectable		 5u63A-4fl3A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jdl ABSCISIC ACID
RECEPTOR PYL5

(Arabidopsis
thaliana) 		PF10604
(Polyketide_cyc2) 		3 HIS A 143
SER A 119
ARG A 107
 None
 1.01A 5u63A-4jdlA:
undetectable		 5u63A-4jdlA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksa MALONYL-COA
DECARBOXYLASE

(Rhodopseudomonas
palustris) 		PF05292
(MCD)
PF17408
(MCD_N) 		3 HIS A 168
SER A 172
ARG A 130
 MG  A 501 (-3.6A)
None
None
 0.85A 5u63A-4ksaA:
undetectable		 5u63A-4ksaA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqw ECF RNA POLYMERASE
SIGMA FACTOR SIGK

(Mycobacterium
tuberculosis) 		PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4) 		3 HIS A  21
SER A  67
ARG A  64
 None
 0.90A 5u63A-4nqwA:
undetectable		 5u63A-4nqwA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica) 		PF12468
(TTSSLRR) 		3 HIS A 462
SER A 441
ARG A 479
 None
 1.03A 5u63A-4ow2A:
undetectable		 5u63A-4ow2A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B

(Vibrio
cholerae;
Vibrio cholerae) 		PF05896
(NQRA)
PF11973
(NQRA_SLBB)
PF03116
(NQR2_RnfD_RnfE) 		3 HIS A 234
SER A 231
ARG B 407
 None
 0.78A 5u63A-4p6vA:
2.8		 5u63A-4p6vA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxb UREIDOGLYCOLATE
HYDROLASE

(Arabidopsis
thaliana) 		PF01546
(Peptidase_M20) 		3 HIS A 138
SER A 182
ARG A  86
 MN  A 501 (-3.5A)
None
None
 0.87A 5u63A-4pxbA:
1.5		 5u63A-4pxbA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qsl PYRUVATE CARBOXYLASE

(Listeria
monocytogenes) 		no annotation 3 HIS H 741
SER H 774
ARG H 540
 None
 1.04A 5u63A-4qslH:
2.2		 5u63A-4qslH:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u0q BASIGIN

(Homo sapiens) 		PF13927
(Ig_3) 		3 HIS B 170
SER B 161
ARG B 166
 None
 0.84A 5u63A-4u0qB:
undetectable		 5u63A-4u0qB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		3 HIS A 519
SER A 538
ARG A 525
 None
 0.96A 5u63A-4xi2A:
undetectable		 5u63A-4xi2A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 HIS A2469
SER A2471
ARG A2478
 None
 0.75A 5u63A-4z37A:
undetectable		 5u63A-4z37A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		3 HIS A 300
SER A 792
ARG A 923
 None
 1.00A 5u63A-5a42A:
undetectable		 5u63A-5a42A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b0n E3 UBIQUITIN-PROTEIN
LIGASE IPAH9.8

(Shigella
flexneri) 		PF12468
(TTSSLRR) 		3 HIS A 126
SER A 145
ARG A 166
 None
 0.91A 5u63A-5b0nA:
undetectable		 5u63A-5b0nA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7o PROLIFERATING CELL
NUCLEAR ANTIGEN

(Leishmania
donovani) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		3 HIS A  49
SER A  36
ARG A  53
 None
 1.00A 5u63A-5b7oA:
undetectable		 5u63A-5b7oA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eo6 COPROPORPHYRINOGEN
OXIDASE

(Acinetobacter
baumannii) 		PF01218
(Coprogen_oxidas) 		3 HIS A 115
SER A 101
ARG A 119
 ACT  A 400 (-3.1A)
None
None
 0.90A 5u63A-5eo6A:
undetectable		 5u63A-5eo6A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkx UNCHARACTERIZED
PROTEIN

(Thermococcus
onnurineus) 		PF14336
(DUF4392) 		3 HIS A 253
SER A 244
ARG A 249
 None
 1.04A 5u63A-5gkxA:
undetectable		 5u63A-5gkxA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE

(Myxococcus
xanthus) 		PF00378
(ECH_1) 		3 HIS A 210
SER A  94
ARG A  45
 None
 1.02A 5u63A-5jbwA:
undetectable		 5u63A-5jbwA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		3 HIS X 188
SER X 211
ARG X 218
 None
NAP  X 401 (-2.8A)
None
 0.95A 5u63A-5liyX:
undetectable		 5u63A-5liyX:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0j SWI5-DEPENDENT HO
EXPRESSION PROTEIN
2,SWI5-DEPENDENT HO
EXPRESSION PROTEIN 3

(Saccharomyces
cerevisiae) 		no annotation 3 HIS D  33
SER D  29
ARG D  63
 None
None
C  E  27 ( 3.2A)
 1.03A 5u63A-5m0jD:
undetectable		 5u63A-5m0jD:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqm GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN

(Bacteroides
thetaiotaomicron) 		PF17132
(Glyco_hydro_106) 		3 HIS A 569
SER A 566
ARG A 599
 None
 0.92A 5u63A-5mqmA:
undetectable		 5u63A-5mqmA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oev GLUTATHIONE
SYNTHETASE-LIKE
EFFECTOR 22
(GPA-GSS22-APO)

(Globodera
pallida) 		no annotation 3 HIS A 460
SER A 483
ARG A 172
 None
 0.89A 5u63A-5oevA:
undetectable		 5u63A-5oevA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u63 THIOREDOXIN
REDUCTASE

(Haemophilus
influenzae) 		PF07992
(Pyr_redox_2) 		3 HIS A 176
SER A 180
ARG A 182
 ACT  A 406 ( 4.0A)
ACT  A 406 (-3.9A)
NAP  A 407 ( 3.1A)
 0.02A 5u63A-5u63A:
53.2		 5u63A-5u63A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN

(Burkholderia
thailandensis) 		no annotation 3 HIS A 139
SER A 166
ARG A 212
 AZ8  A 302 (-4.5A)
None
AZ8  A 302 (-3.9A)
 0.65A 5u63A-5ufmA:
2.4		 5u63A-5ufmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uja BOVINE MULTIDRUG
RESISTANCE PROTEIN 1
(MRP1),MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		3 HIS A 494
SER A 497
ARG A 532
 None
 1.01A 5u63A-5ujaA:
undetectable		 5u63A-5ujaA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1

(Schizosaccharomyces
pombe) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		3 HIS A 305
SER A 308
ARG A 311
 None
 1.01A 5u63A-5um6A:
6.3		 5u63A-5um6A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkv CYTOCHROME C-TYPE
BIOGENESIS PROTEIN
CCDA

(Thermus
thermophilus) 		no annotation 3 HIS A 181
SER A 180
ARG A 174
 None
 0.91A 5u63A-5vkvA:
undetectable		 5u63A-5vkvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyw PYRUVATE CARBOXYLASE

(Lactococcus
lactis) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 HIS A 734
SER A 767
ARG A 533
 MN  A1201 (-4.0A)
None
MN  A1201 ( 4.5A)
 0.97A 5u63A-5vywA:
1.3		 5u63A-5vywA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1

(Saccharomyces
cerevisiae) 		no annotation 3 HIS C 553
SER C 552
ARG C 504
 None
 1.00A 5u63A-5x6oC:
undetectable		 5u63A-5x6oC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwc POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
CAPD

(Bacillus
thuringiensis) 		no annotation 3 HIS A  88
SER A 176
ARG A 174
 UD1  A 402 ( 3.9A)
UD1  A 402 (-4.3A)
NAP  A 401 (-3.8A)
 1.01A 5u63A-6bwcA:
3.7		 5u63A-6bwcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3

(Homo sapiens) 		no annotation 3 HIS A 194
SER A 217
ARG A 223
 None
NAP  A 401 ( 2.7A)
None
 0.93A 5u63A-6f2uA:
undetectable		 5u63A-6f2uA:
undetectable