SIMILAR PATTERNS OF AMINO ACIDS FOR 5U63_A_ACTA405_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cc1 | HYDROGENASE (LARGESUBUNIT) (Desulfomicrobiumbaculatum) |
PF00374(NiFeSe_Hases) | 3 | GLY L 299LEU L 300HIS L 294 | None | 0.70A | 5u63A-1cc1L:undetectable | 5u63A-1cc1L:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1glv | GLUTATHIONE SYNTHASE (Escherichiacoli) |
PF02951(GSH-S_N)PF02955(GSH-S_ATP) | 3 | GLY A 5LEU A 80HIS A 36 | None | 0.63A | 5u63A-1glvA:undetectable | 5u63A-1glvA:26.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i7q | ANTHRANILATESYNTHASE (Serratiamarcescens) |
PF00425(Chorismate_bind)PF04715(Anth_synt_I_N) | 3 | GLY A 328LEU A 399HIS A 362 | BEZ A1501 (-3.3A)NoneNone | 0.63A | 5u63A-1i7qA:undetectable | 5u63A-1i7qA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1khd | ANTHRANILATEPHOSPHORIBOSYLTRANSFERASE (Pectobacteriumcarotovorum) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N) | 3 | GLY A 294LEU A 289HIS A 298 | None | 0.60A | 5u63A-1khdA:3.1 | 5u63A-1khdA:23.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m22 | PEPTIDE AMIDASE (Stenotrophomonasmaltophilia) |
PF01425(Amidase) | 3 | GLY A 113LEU A 111HIS A 116 | None | 0.63A | 5u63A-1m22A:undetectable | 5u63A-1m22A:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mhy | METHANEMONOOXYGENASEHYDROXYLASEMETHANEMONOOXYGENASEHYDROXYLASE (Methylosinustrichosporium;Methylosinustrichosporium) |
PF02332(Phenol_Hydrox)PF02964(MeMO_Hyd_G) | 3 | GLY G 137LEU G 140HIS B 80 | None | 0.70A | 5u63A-1mhyG:undetectable | 5u63A-1mhyG:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p9m | INTERLEUKIN-6RECEPTOR BETA CHAIN (Homo sapiens) |
PF00041(fn3)PF06328(Lep_receptor_Ig)PF09240(IL6Ra-bind) | 3 | GLY A 101LEU A 75HIS A 131 | None | 0.68A | 5u63A-1p9mA:undetectable | 5u63A-1p9mA:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pby | QUINOHEMOPROTEINAMINE DEHYDROGENASE40 KDA SUBUNIT (Paracoccusdenitrificans) |
no annotation | 3 | GLY B 196LEU B 226HIS B 192 | None | 0.54A | 5u63A-1pbyB:undetectable | 5u63A-1pbyB:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qs0 | 2-OXOISOVALERATEDEHYDROGENASEALPHA-SUBUNIT (Pseudomonasputida) |
PF00676(E1_dh)PF12573(OxoDH_E1alpha_N) | 3 | GLY A 62LEU A 58HIS A 342 | None | 0.60A | 5u63A-1qs0A:undetectable | 5u63A-1qs0A:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s58 | B19 PARVOVIRUSCAPSID (Primateerythroparvovirus1) |
PF00740(Parvo_coat) | 3 | GLY A 372LEU A 544HIS A 354 | None | 0.63A | 5u63A-1s58A:undetectable | 5u63A-1s58A:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uli | BIPHENYL DIOXYGENASELARGE SUBUNIT (Rhodococcusjostii) |
PF00355(Rieske)PF00848(Ring_hydroxyl_A) | 3 | GLY A 306LEU A 300HIS A 187 | None | 0.70A | 5u63A-1uliA:undetectable | 5u63A-1uliA:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1usy | ATPPHOSPHORIBOSYLTRANSFERASE (Thermotogamaritima) |
PF01634(HisG) | 3 | GLY E 64LEU E 68HIS E 172 | NoneNoneHIS E1205 (-3.4A) | 0.60A | 5u63A-1usyE:undetectable | 5u63A-1usyE:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w78 | FOLC BIFUNCTIONALPROTEIN (Escherichiacoli) |
PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 3 | GLY A 150LEU A 149HIS A 173 | KCX A 188 ( 3.4A)PD8 A1421 ( 4.4A) MG A1422 ( 3.4A) | 0.67A | 5u63A-1w78A:2.3 | 5u63A-1w78A:24.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y3t | HYPOTHETICAL PROTEINYXAG (Bacillussubtilis) |
PF07883(Cupin_2) | 3 | GLY A 293LEU A 294HIS A 239 | None | 0.50A | 5u63A-1y3tA:undetectable | 5u63A-1y3tA:24.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y9a | NADP-DEPENDENTALCOHOLDEHYDROGENASE (Entamoebahistolytica) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 3 | GLY A 263LEU A 161HIS A 291 | None | 0.65A | 5u63A-1y9aA:3.5 | 5u63A-1y9aA:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2btv | PROTEIN (VP3 COREPROTEIN) (Bluetonguevirus) |
PF01700(Orbi_VP3) | 3 | GLY A 374LEU A 402HIS A 378 | None | 0.58A | 5u63A-2btvA:undetectable | 5u63A-2btvA:14.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bvg | 6-HYDROXY-D-NICOTINEOXIDASE (Paenarthrobacternicotinovorans) |
PF01565(FAD_binding_4)PF08031(BBE) | 3 | GLY A 152LEU A 153HIS A 366 | None | 0.70A | 5u63A-2bvgA:undetectable | 5u63A-2bvgA:23.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eq9 | PYRUVATEDEHYDROGENASECOMPLEX,DIHYDROLIPOAMIDEDEHYDROGENASE E3COMPONENT (Thermusthermophilus) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 3 | GLY A 329LEU A 330HIS A 23 | None | 0.71A | 5u63A-2eq9A:27.0 | 5u63A-2eq9A:24.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fqd | BLUE COPPER OXIDASECUEO (Escherichiacoli) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 3 | GLY A 436LEU A 353HIS A 443 | NoneNone CU A 601 (-3.2A) | 0.57A | 5u63A-2fqdA:undetectable | 5u63A-2fqdA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gk4 | CONSERVEDHYPOTHETICAL PROTEIN (Streptococcuspneumoniae) |
PF04127(DFP) | 3 | GLY A 26LEU A 52HIS A 27 | None | 0.67A | 5u63A-2gk4A:4.6 | 5u63A-2gk4A:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gtl | HEMOGLOBIN LINKERCHAIN L1 (Lumbricusterrestris) |
PF00057(Ldl_recept_a)PF16915(Eryth_link_C) | 3 | GLY M 113LEU M 114HIS M 127 | None | 0.67A | 5u63A-2gtlM:undetectable | 5u63A-2gtlM:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gwg | 4-OXALOMESACONATEHYDRATASE (Rhodopseudomonaspalustris) |
PF04909(Amidohydro_2) | 3 | GLY A 226LEU A 195HIS A 223 | None | 0.54A | 5u63A-2gwgA:undetectable | 5u63A-2gwgA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kb3 | OXOGLUTARATEDEHYDROGENASEINHIBITOR (Corynebacteriumglutamicum) |
PF00498(FHA) | 3 | GLY A 105LEU A 107HIS A 89 | NoneTPO A 15 ( 2.5A)None | 0.64A | 5u63A-2kb3A:undetectable | 5u63A-2kb3A:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kl2 | AIG2-LIKEDOMAIN-CONTAININGPROTEIN 1 (Mus musculus) |
PF06094(GGACT) | 3 | GLY A 140LEU A 141HIS A 139 | None | 0.65A | 5u63A-2kl2A:undetectable | 5u63A-2kl2A:17.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2msv | MIXED LINEAGE KINASEDOMAIN-LIKE PROTEIN (Homo sapiens) |
no annotation | 3 | GLY A 32LEU A 36HIS A 15 | None | 0.62A | 5u63A-2msvA:undetectable | 5u63A-2msvA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2om5 | CONTACTIN 2 (Homo sapiens) |
PF07679(I-set)PF13927(Ig_3) | 3 | GLY A 133LEU A 134HIS A 130 | None | 0.70A | 5u63A-2om5A:undetectable | 5u63A-2om5A:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qtn | NICOTINATE(NICOTINAMIDE)NUCLEOTIDEADENYLYLTRANSFERASE (Bacillusanthracis) |
PF01467(CTP_transf_like) | 3 | GLY A 5LEU A 31HIS A 102 | None | 0.71A | 5u63A-2qtnA:undetectable | 5u63A-2qtnA:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r98 | PUTATIVEACETYLGLUTAMATESYNTHASE (Neisseriagonorrhoeae) |
PF00583(Acetyltransf_1)PF00696(AA_kinase) | 3 | GLY A 32LEU A 35HIS A 61 | None | 0.45A | 5u63A-2r98A:undetectable | 5u63A-2r98A:23.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vdc | GLUTAMATE SYNTHASE[NADPH] LARGE CHAIN (Azospirillumbrasilense) |
PF00310(GATase_2)PF01493(GXGXG)PF01645(Glu_synthase)PF04898(Glu_syn_central) | 3 | GLY A1283LEU A1259HIS A1263 | None | 0.71A | 5u63A-2vdcA:undetectable | 5u63A-2vdcA:13.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vw8 | PA1000 (Pseudomonasaeruginosa) |
PF00753(Lactamase_B) | 3 | GLY A 146LEU A 29HIS A 149 | None | 0.58A | 5u63A-2vw8A:undetectable | 5u63A-2vw8A:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wk8 | CAI-1 AUTOINDUCERSYNTHASE (Vibrio cholerae) |
PF00155(Aminotran_1_2) | 3 | GLY A 216LEU A 217HIS A 210 | None | 0.58A | 5u63A-2wk8A:undetectable | 5u63A-2wk8A:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bs8 | GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE (Bacillussubtilis) |
PF00202(Aminotran_3) | 3 | GLY A 147LEU A 152HIS A 146 | PMP A 431 ( 3.7A)NoneNone | 0.63A | 5u63A-3bs8A:undetectable | 5u63A-3bs8A:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3btu | GALACTOSE/LACTOSEMETABOLISMREGULATORY PROTEINGAL80 (Saccharomycescerevisiae) |
PF01408(GFO_IDH_MocA) | 3 | GLY A 152LEU A 150HIS A 213 | None | 0.69A | 5u63A-3btuA:3.0 | 5u63A-3btuA:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e1k | GALACTOSE/LACTOSEMETABOLISMREGULATORY PROTEINGAL80 (Kluyveromyceslactis) |
PF01408(GFO_IDH_MocA) | 3 | GLY A 153LEU A 151HIS A 214 | None | 0.66A | 5u63A-3e1kA:3.1 | 5u63A-3e1kA:23.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e73 | LANC-LIKE PROTEIN 1 (Homo sapiens) |
PF05147(LANC_like) | 3 | GLY A 324LEU A 315HIS A 274 | NoneNoneGSH A 502 (-4.0A) | 0.70A | 5u63A-3e73A:undetectable | 5u63A-3e73A:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eqq | BENZENE1,2-DIOXYGENASESUBUNIT ALPHA (Pseudomonasputida) |
PF00355(Rieske)PF00848(Ring_hydroxyl_A) | 3 | GLY A 304LEU A 298HIS A 185 | None | 0.69A | 5u63A-3eqqA:undetectable | 5u63A-3eqqA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fge | PUTATIVE FLAVINREDUCTASE WITH SPLITBARREL DOMAIN (Shewanellafrigidimarina) |
PF01613(Flavin_Reduct) | 3 | GLY A 184LEU A 185HIS A 18 | None | 0.68A | 5u63A-3fgeA:undetectable | 5u63A-3fgeA:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fh2 | PROBABLEATP-DEPENDENTPROTEASE (HEAT SHOCKPROTEIN) (Corynebacteriumglutamicum) |
PF02861(Clp_N) | 3 | GLY A 36LEU A 15HIS A 39 | None | 0.63A | 5u63A-3fh2A:undetectable | 5u63A-3fh2A:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ftb | HISTIDINOL-PHOSPHATEAMINOTRANSFERASE (Clostridiumacetobutylicum) |
PF00155(Aminotran_1_2) | 3 | GLY A 159LEU A 160HIS A 296 | None | 0.43A | 5u63A-3ftbA:2.3 | 5u63A-3ftbA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h2i | ESTERASE (Xanthomonasoryzae) |
PF03583(LIP) | 3 | GLY A 127LEU A 128HIS A 136 | None | 0.49A | 5u63A-3h2iA:1.6 | 5u63A-3h2iA:23.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ib3 | COCE/NOND FAMILYHYDROLASE (Staphylococcusaureus) |
PF02129(Peptidase_S15)PF08530(PepX_C) | 3 | GLY A 206LEU A 457HIS A 476 | None | 0.65A | 5u63A-3ib3A:undetectable | 5u63A-3ib3A:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j3i | CAPSID PROTEIN (Penicilliumchrysogenumvirus) |
no annotation | 3 | GLY A 468LEU A 471HIS A 462 | None | 0.64A | 5u63A-3j3iA:undetectable | 5u63A-3j3iA:16.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k28 | GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE2 (Bacillusanthracis) |
PF00202(Aminotran_3) | 3 | GLY A 147LEU A 152HIS A 146 | PLP A 900 (-3.8A)NoneNone | 0.65A | 5u63A-3k28A:undetectable | 5u63A-3k28A:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l01 | GLGA GLYCOGENSYNTHASE (Pyrococcusabyssi) |
PF00534(Glycos_transf_1)PF08323(Glyco_transf_5) | 3 | GLY A 7LEU A 22HIS A 127 | None | 0.70A | 5u63A-3l01A:3.4 | 5u63A-3l01A:24.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lot | UNCHARACTERIZEDPROTEIN (Archaeoglobusfulgidus) |
PF05853(BKACE) | 3 | GLY A 237LEU A 245HIS A 202 | None | 0.61A | 5u63A-3lotA:undetectable | 5u63A-3lotA:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lp8 | PHOSPHORIBOSYLAMINE-GLYCINE LIGASE (Ehrlichiachaffeensis) |
PF01071(GARS_A)PF02843(GARS_C)PF02844(GARS_N) | 3 | GLY A 10LEU A 363HIS A 13 | None | 0.70A | 5u63A-3lp8A:3.2 | 5u63A-3lp8A:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lps | TOPOISOMERASE IVSUBUNIT B (Xanthomonasoryzae) |
PF00204(DNA_gyraseB)PF02518(HATPase_c) | 3 | GLY A 130LEU A 133HIS A 123 | None | 0.50A | 5u63A-3lpsA:undetectable | 5u63A-3lpsA:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mdn | GLUTAMINEAMINOTRANSFERASECLASS-II DOMAINPROTEIN (Ruegeriapomeroyi) |
PF13230(GATase_4) | 3 | GLY A 80LEU A 81HIS A 8 | None | 0.63A | 5u63A-3mdnA:undetectable | 5u63A-3mdnA:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ml0 | PENICILLIN GACYLASE, ALPHASUBUNIT (Alcaligenesfaecalis) |
PF01804(Penicil_amidase) | 3 | GLY A 172LEU A 175HIS A 167 | None | 0.61A | 5u63A-3ml0A:undetectable | 5u63A-3ml0A:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n2e | SHIKIMATE KINASE (Helicobacterpylori) |
PF01202(SKI) | 3 | GLY A 92LEU A 91HIS A 3 | None | 0.58A | 5u63A-3n2eA:2.4 | 5u63A-3n2eA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n2t | PUTATIVEOXIDOREDUCTASE (Gluconobacteroxydans) |
PF00248(Aldo_ket_red) | 3 | GLY A 86LEU A 87HIS A 130 | None | 0.65A | 5u63A-3n2tA:undetectable | 5u63A-3n2tA:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nsw | EXCRETORY-SECRETORYPROTEIN 2 (Ancylostomaceylanicum) |
no annotation | 3 | GLY A 91LEU A 92HIS A 89 | None | 0.67A | 5u63A-3nswA:undetectable | 5u63A-3nswA:17.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o65 | PUTATIVEATAXIN-3-LIKEPROTEIN (Homo sapiens) |
PF02099(Josephin) | 3 | GLY A 128LEU A 179HIS A 130 | None | 0.67A | 5u63A-3o65A:undetectable | 5u63A-3o65A:18.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qr1 | PHOSPHOLIPASE C-BETA(PLC-BETA) (Doryteuthispealeii) |
PF00168(C2)PF00387(PI-PLC-Y)PF00388(PI-PLC-X)PF09279(EF-hand_like) | 3 | GLY A 437LEU A 440HIS A 433 | None | 0.66A | 5u63A-3qr1A:undetectable | 5u63A-3qr1A:18.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qt4 | CATHEPSIN-L-LIKEMIDGUT CYSTEINEPROTEINASE (Tenebriomolitor) |
PF00112(Peptidase_C1)PF08246(Inhibitor_I29) | 3 | GLY A 207LEU A 88HIS A 175 | None | 0.70A | 5u63A-3qt4A:undetectable | 5u63A-3qt4A:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rd8 | FUMARATE HYDRATASECLASS II (Mycolicibacteriumsmegmatis) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 3 | GLY A 220LEU A 219HIS A 146 | None | 0.68A | 5u63A-3rd8A:undetectable | 5u63A-3rd8A:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s4d | LACTOSEPHOSPHORYLASE (Cellulomonasuda) |
PF06165(Glyco_transf_36)PF17167(Glyco_hydro_36) | 3 | GLY A 479LEU A 480HIS A 478 | None | 0.69A | 5u63A-3s4dA:undetectable | 5u63A-3s4dA:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ugm | TAL EFFECTORAVRBS3/PTHA (Xanthomonasoryzae) |
PF03377(TAL_effector) | 3 | GLY A 593LEU A 594HIS A 592 | None | 0.67A | 5u63A-3ugmA:undetectable | 5u63A-3ugmA:15.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wdb | PROBABLEATP-DEPENDENT CLPPROTEASE ATP-BINDINGSUBUNIT (Mycobacteriumtuberculosis) |
PF02861(Clp_N) | 3 | GLY A 36LEU A 15HIS A 39 | None | 0.63A | 5u63A-3wdbA:undetectable | 5u63A-3wdbA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bwc | PHOSPHOLIPASE B-LIKE1PHOSPHOLIPASE B-LIKE1 (Bos taurus;Bos taurus) |
PF04916(Phospholip_B)PF04916(Phospholip_B) | 3 | GLY B 279LEU A 193HIS A 114 | None | 0.67A | 5u63A-4bwcB:undetectable | 5u63A-4bwcB:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ezi | UNCHARACTERIZEDPROTEIN (Legionellapneumophila) |
no annotation | 3 | GLY A 146LEU A 147HIS A 155 | None | 0.48A | 5u63A-4eziA:undetectable | 5u63A-4eziA:25.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gvf | BETA-HEXOSAMINIDASE (Salmonellaenterica) |
PF00933(Glyco_hydro_3) | 3 | GLY A 93LEU A 96HIS A 88 | None | 0.70A | 5u63A-4gvfA:undetectable | 5u63A-4gvfA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iox | TRIPARTITE TERMINASESUBUNIT UL15 (Humanalphaherpesvirus1) |
PF02499(DNA_pack_C) | 3 | GLY A 522LEU A 708HIS A 540 | None | 0.68A | 5u63A-4ioxA:undetectable | 5u63A-4ioxA:24.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k0r | CRYPTOCHROME-1 (Mus musculus) |
PF00875(DNA_photolyase)PF03441(FAD_binding_7) | 3 | GLY A 250LEU A 251HIS A 224 | None | 0.40A | 5u63A-4k0rA:undetectable | 5u63A-4k0rA:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kl0 | PUTATIVEUNCHARACTERIZEDPROTEIN (Xanthomonasoryzae) |
PF01156(IU_nuc_hydro) | 3 | GLY A 149LEU A 148HIS A 191 | None | 0.52A | 5u63A-4kl0A:2.4 | 5u63A-4kl0A:24.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mh1 | SORBOSEDEHYDROGENASE (Ketogulonicigeniumvulgare) |
PF13360(PQQ_2) | 3 | GLY A 134LEU A 129HIS A 90 | None | 0.65A | 5u63A-4mh1A:undetectable | 5u63A-4mh1A:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nql | AMSH-LIKE PROTEASESST2 (Schizosaccharomycespombe) |
PF01398(JAB) | 3 | GLY A 293LEU A 334HIS A 304 | None | 0.70A | 5u63A-4nqlA:undetectable | 5u63A-4nqlA:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pne | METHYLTRANSFERASE-LIKE PROTEIN (Saccharopolysporaspinosa) |
PF08241(Methyltransf_11) | 3 | GLY A 43LEU A 60HIS A 41 | NoneNoneSAH A 301 ( 3.6A) | 0.62A | 5u63A-4pneA:2.2 | 5u63A-4pneA:24.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qmh | LP04448P (Drosophilamelanogaster) |
PF12348(CLASP_N) | 3 | GLY A1047LEU A1006HIS A1051 | None | 0.61A | 5u63A-4qmhA:undetectable | 5u63A-4qmhA:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qq2 | C1Q-RELATED FACTOR (Mus musculus) |
PF00386(C1q) | 3 | GLY A 120LEU A 15HIS A 19 | None | 0.70A | 5u63A-4qq2A:undetectable | 5u63A-4qq2A:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qri | HYPOXANTHINE-GUANINE-XANTHINEPHOSPHORIBOSYLTRANSFERASE (Leptospirainterrogans) |
PF00156(Pribosyltran) | 3 | GLY A 156LEU A 168HIS A 172 | None | 0.63A | 5u63A-4qriA:undetectable | 5u63A-4qriA:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ric | FANCONI-ASSOCIATEDNUCLEASE 1 (Homo sapiens) |
PF08774(VRR_NUC) | 3 | GLY A 741LEU A 744HIS A 985 | None | 0.55A | 5u63A-4ricA:undetectable | 5u63A-4ricA:17.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tqg | PUTATIVEDTDP-D-GLUCOSE 46-DEHYDRATASE (Megaviruschiliensis) |
PF02719(Polysacc_synt_2) | 3 | GLY A 256LEU A 257HIS A 198 | None | 0.49A | 5u63A-4tqgA:3.4 | 5u63A-4tqgA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4txg | CHITINASE (Chromobacteriumviolaceum) |
PF00704(Glyco_hydro_18)PF06483(ChiC) | 3 | GLY A 732LEU A 730HIS A 722 | None | 0.63A | 5u63A-4txgA:undetectable | 5u63A-4txgA:18.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u8h | CRYPTOCHROME-2 (Mus musculus) |
PF00875(DNA_photolyase)PF03441(FAD_binding_7) | 3 | GLY A 268LEU A 269HIS A 242 | None | 0.56A | 5u63A-4u8hA:undetectable | 5u63A-4u8hA:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ud8 | FAD-BINDING AND BBEDOMAIN-CONTAININGPROTEIN (Arabidopsisthaliana) |
PF01565(FAD_binding_4)PF08031(BBE) | 3 | GLY A 183LEU A 182HIS A 115 | FAD A 601 (-3.6A)FAD A 601 (-4.5A)FAD A 601 (-2.5A) | 0.58A | 5u63A-4ud8A:undetectable | 5u63A-4ud8A:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b04 | PROBABLE TRANSLATIONINITIATION FACTOREIF-2B SUBUNIT BETAPROBABLE TRANSLATIONINITIATION FACTOREIF-2B SUBUNIT DELTA (Schizosaccharomycespombe;Schizosaccharomycespombe) |
PF01008(IF-2B)PF01008(IF-2B) | 3 | GLY G 414LEU G 416HIS C 243 | None | 0.71A | 5u63A-5b04G:undetectable | 5u63A-5b04G:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bjx | WLAL PROTEIN (Campylobacterjejuni) |
no annotation | 3 | GLY A 521LEU A 522HIS A 459 | None | 0.68A | 5u63A-5bjxA:4.2 | 5u63A-5bjxA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bu9 | BETA-N-ACETYLHEXOSAMINIDASE (Beutenbergiacavernae) |
PF00933(Glyco_hydro_3) | 3 | GLY A 256LEU A 257HIS A 253 | NoneNoneGOL A 501 (-3.8A) | 0.68A | 5u63A-5bu9A:undetectable | 5u63A-5bu9A:24.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cj5 | ALPHA-1,4-GLUCAN:MALTOSE-1-PHOSPHATEMALTOSYLTRANSFERASE (Mycolicibacteriumthermoresistibile) |
PF00128(Alpha-amylase)PF11896(DUF3416) | 3 | GLY A 53LEU A 113HIS A 52 | None | 0.66A | 5u63A-5cj5A:undetectable | 5u63A-5cj5A:17.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ck3 | SRX DOMAINPUTATIVE SIGNALRECOGNITION PARTICLEPROTEIN (Chaetomiumthermophilum;Chaetomiumthermophilum) |
PF04086(SRP-alpha_N)PF09439(SRPRB) | 3 | GLY A 13LEU A 9HIS B 105 | MG B 401 ( 4.5A)NoneNone | 0.69A | 5u63A-5ck3A:undetectable | 5u63A-5ck3A:18.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cww | NUCLEOPORIN NUP82 (Chaetomiumthermophilum) |
no annotation | 3 | GLY B 435LEU B 479HIS B 506 | None | 0.64A | 5u63A-5cwwB:undetectable | 5u63A-5cwwB:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e6p | PLEXIN-B2 (Mus musculus) |
PF08337(Plexin_cytopl) | 3 | GLY A1364LEU A1366HIS A1363 | None | 0.71A | 5u63A-5e6pA:undetectable | 5u63A-5e6pA:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g4i | PHOSPHOLYASE (Paenarthrobacteraurescens) |
PF00202(Aminotran_3) | 3 | GLY A 211LEU A 205HIS A 210 | None | 0.70A | 5u63A-5g4iA:undetectable | 5u63A-5g4iA:22.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gt2 | PROBABLEDEFERROCHELATASE/PEROXIDASE YFEX (Escherichiacoli) |
PF04261(Dyp_perox) | 3 | GLY A 246LEU A 139HIS A 245 | None | 0.68A | 5u63A-5gt2A:undetectable | 5u63A-5gt2A:25.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gt5 | PECTATE LYASE (Paenibacillussp. 0602) |
no annotation | 3 | GLY A 90LEU A 86HIS A 114 | None | 0.62A | 5u63A-5gt5A:undetectable | 5u63A-5gt5A:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i5d | INNER MEMBRANEPROTEIN YEJM (Salmonellaenterica) |
PF00884(Sulfatase)PF11893(DUF3413) | 3 | GLY A 308LEU A 309HIS A 491 | None | 0.64A | 5u63A-5i5dA:undetectable | 5u63A-5i5dA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i5h | INNER MEMBRANEPROTEIN YEJM (Escherichiacoli) |
PF00884(Sulfatase)PF11893(DUF3413) | 3 | GLY A 308LEU A 309HIS A 491 | None | 0.65A | 5u63A-5i5hA:undetectable | 5u63A-5i5hA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iz3 | PREDICTED PROTEIN (Physcomitrellapatens) |
PF00316(FBPase) | 3 | GLY B 81LEU B 80HIS B 249 | None | 0.70A | 5u63A-5iz3B:undetectable | 5u63A-5iz3B:26.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n0l | GTP-SENSINGTRANSCRIPTIONALPLEIOTROPICREPRESSOR CODY (Clostridioidesdifficile) |
no annotation | 3 | GLY A 106LEU A 108HIS A 105 | None | 0.67A | 5u63A-5n0lA:undetectable | 5u63A-5n0lA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nko | RIBOSOME HIBERNATIONPROMOTION FACTOR (Staphylococcusaureus) |
PF16321(Ribosom_S30AE_C) | 3 | GLY A 157LEU A 156HIS A 158 | None | 0.67A | 5u63A-5nkoA:undetectable | 5u63A-5nkoA:11.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t5x | CRYPTOCHROME-1 (Mus musculus) |
PF00875(DNA_photolyase)PF03441(FAD_binding_7) | 3 | GLY A 250LEU A 251HIS A 224 | None | 0.46A | 5u63A-5t5xA:undetectable | 5u63A-5t5xA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tw1 | DNA-DIRECTED RNAPOLYMERASE SUBUNITBETA (Mycolicibacteriumsmegmatis) |
PF00562(RNA_pol_Rpb2_6)PF04560(RNA_pol_Rpb2_7)PF04561(RNA_pol_Rpb2_2)PF04563(RNA_pol_Rpb2_1)PF04565(RNA_pol_Rpb2_3)PF10385(RNA_pol_Rpb2_45) | 3 | GLY C 920LEU C 923HIS C 590 | None | 0.65A | 5u63A-5tw1C:undetectable | 5u63A-5tw1C:14.47 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5u63 | THIOREDOXINREDUCTASE (Haemophilusinfluenzae) |
PF07992(Pyr_redox_2) | 3 | GLY A 37LEU A 38HIS A 84 | FAD A 401 ( 3.1A)ACT A 405 ( 3.6A)ACT A 405 ( 3.9A) | 0.05A | 5u63A-5u63A:53.2 | 5u63A-5u63A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uy3 | ANTIBODY PGT144 FABHEAVY CHAIN (Homo sapiens) |
no annotation | 3 | GLY H 94LEU H 105HIS H 35 | None | 0.61A | 5u63A-5uy3H:undetectable | 5u63A-5uy3H:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xmj | FUMARATE REDUCTASEFLAVOPROTEIN SUBUNIT (Desulfovibriogigas) |
no annotation | 3 | GLY A 189LEU A 386HIS A 186 | None | 0.66A | 5u63A-5xmjA:14.5 | 5u63A-5xmjA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xqo | PCRGLX PROTEIN (Penicilliumchrysogenum) |
no annotation | 3 | GLY A 47LEU A 48HIS A 92 | None | 0.59A | 5u63A-5xqoA:undetectable | 5u63A-5xqoA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ar2 | SARCOLEMMALMEMBRANE-ASSOCIATEDPROTEIN (Homo sapiens) |
no annotation | 3 | GLY A 31LEU A 51HIS A 55 | None | 0.70A | 5u63A-6ar2A:undetectable | 5u63A-6ar2A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6blg | DTDP-4-AMINO-4,6-DIDEOXYGALACTOSETRANSAMINASE (Klebsiellapneumoniae) |
no annotation | 3 | GLY A 156LEU A 166HIS A 127 | None | 0.68A | 5u63A-6blgA:undetectable | 5u63A-6blgA:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cfw | MBH13 NADHDEHYDROGENASESUBUNIT (Pyrococcusfuriosus) |
no annotation | 3 | GLY M 159LEU M 158HIS M 172 | None | 0.64A | 5u63A-6cfwM:undetectable | 5u63A-6cfwM:undetectable |