SIMILAR PATTERNS OF AMINO ACIDS FOR 5U63_A_ACTA405_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cc1 HYDROGENASE (LARGE
SUBUNIT)


(Desulfomicrobium
baculatum)
PF00374
(NiFeSe_Hases)
3 GLY L 299
LEU L 300
HIS L 294
None
0.70A 5u63A-1cc1L:
undetectable
5u63A-1cc1L:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1glv GLUTATHIONE SYNTHASE

(Escherichia
coli)
PF02951
(GSH-S_N)
PF02955
(GSH-S_ATP)
3 GLY A   5
LEU A  80
HIS A  36
None
0.63A 5u63A-1glvA:
undetectable
5u63A-1glvA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE


(Serratia
marcescens)
PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N)
3 GLY A 328
LEU A 399
HIS A 362
BEZ  A1501 (-3.3A)
None
None
0.63A 5u63A-1i7qA:
undetectable
5u63A-1i7qA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khd ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE


(Pectobacterium
carotovorum)
PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
3 GLY A 294
LEU A 289
HIS A 298
None
0.60A 5u63A-1khdA:
3.1
5u63A-1khdA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m22 PEPTIDE AMIDASE

(Stenotrophomonas
maltophilia)
PF01425
(Amidase)
3 GLY A 113
LEU A 111
HIS A 116
None
0.63A 5u63A-1m22A:
undetectable
5u63A-1m22A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhy METHANE
MONOOXYGENASE
HYDROXYLASE
METHANE
MONOOXYGENASE
HYDROXYLASE


(Methylosinus
trichosporium;
Methylosinus
trichosporium)
PF02332
(Phenol_Hydrox)
PF02964
(MeMO_Hyd_G)
3 GLY G 137
LEU G 140
HIS B  80
None
0.70A 5u63A-1mhyG:
undetectable
5u63A-1mhyG:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9m INTERLEUKIN-6
RECEPTOR BETA CHAIN


(Homo sapiens)
PF00041
(fn3)
PF06328
(Lep_receptor_Ig)
PF09240
(IL6Ra-bind)
3 GLY A 101
LEU A  75
HIS A 131
None
0.68A 5u63A-1p9mA:
undetectable
5u63A-1p9mA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
40 KDA SUBUNIT


(Paracoccus
denitrificans)
no annotation 3 GLY B 196
LEU B 226
HIS B 192
None
0.54A 5u63A-1pbyB:
undetectable
5u63A-1pbyB:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs0 2-OXOISOVALERATE
DEHYDROGENASE
ALPHA-SUBUNIT


(Pseudomonas
putida)
PF00676
(E1_dh)
PF12573
(OxoDH_E1alpha_N)
3 GLY A  62
LEU A  58
HIS A 342
None
0.60A 5u63A-1qs0A:
undetectable
5u63A-1qs0A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s58 B19 PARVOVIRUS
CAPSID


(Primate
erythroparvovirus
1)
PF00740
(Parvo_coat)
3 GLY A 372
LEU A 544
HIS A 354
None
0.63A 5u63A-1s58A:
undetectable
5u63A-1s58A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uli BIPHENYL DIOXYGENASE
LARGE SUBUNIT


(Rhodococcus
jostii)
PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A)
3 GLY A 306
LEU A 300
HIS A 187
None
0.70A 5u63A-1uliA:
undetectable
5u63A-1uliA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE


(Thermotoga
maritima)
PF01634
(HisG)
3 GLY E  64
LEU E  68
HIS E 172
None
None
HIS  E1205 (-3.4A)
0.60A 5u63A-1usyE:
undetectable
5u63A-1usyE:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w78 FOLC BIFUNCTIONAL
PROTEIN


(Escherichia
coli)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
3 GLY A 150
LEU A 149
HIS A 173
KCX  A 188 ( 3.4A)
PD8  A1421 ( 4.4A)
MG  A1422 ( 3.4A)
0.67A 5u63A-1w78A:
2.3
5u63A-1w78A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3t HYPOTHETICAL PROTEIN
YXAG


(Bacillus
subtilis)
PF07883
(Cupin_2)
3 GLY A 293
LEU A 294
HIS A 239
None
0.50A 5u63A-1y3tA:
undetectable
5u63A-1y3tA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE


(Entamoeba
histolytica)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
3 GLY A 263
LEU A 161
HIS A 291
None
0.65A 5u63A-1y9aA:
3.5
5u63A-1y9aA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP3 CORE
PROTEIN)


(Bluetongue
virus)
PF01700
(Orbi_VP3)
3 GLY A 374
LEU A 402
HIS A 378
None
0.58A 5u63A-2btvA:
undetectable
5u63A-2btvA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvg 6-HYDROXY-D-NICOTINE
OXIDASE


(Paenarthrobacter
nicotinovorans)
PF01565
(FAD_binding_4)
PF08031
(BBE)
3 GLY A 152
LEU A 153
HIS A 366
None
0.70A 5u63A-2bvgA:
undetectable
5u63A-2bvgA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT


(Thermus
thermophilus)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
3 GLY A 329
LEU A 330
HIS A  23
None
0.71A 5u63A-2eq9A:
27.0
5u63A-2eq9A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO


(Escherichia
coli)
PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
3 GLY A 436
LEU A 353
HIS A 443
None
None
CU  A 601 (-3.2A)
0.57A 5u63A-2fqdA:
undetectable
5u63A-2fqdA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk4 CONSERVED
HYPOTHETICAL PROTEIN


(Streptococcus
pneumoniae)
PF04127
(DFP)
3 GLY A  26
LEU A  52
HIS A  27
None
0.67A 5u63A-2gk4A:
4.6
5u63A-2gk4A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtl HEMOGLOBIN LINKER
CHAIN L1


(Lumbricus
terrestris)
PF00057
(Ldl_recept_a)
PF16915
(Eryth_link_C)
3 GLY M 113
LEU M 114
HIS M 127
None
0.67A 5u63A-2gtlM:
undetectable
5u63A-2gtlM:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwg 4-OXALOMESACONATE
HYDRATASE


(Rhodopseudomonas
palustris)
PF04909
(Amidohydro_2)
3 GLY A 226
LEU A 195
HIS A 223
None
0.54A 5u63A-2gwgA:
undetectable
5u63A-2gwgA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kb3 OXOGLUTARATE
DEHYDROGENASE
INHIBITOR


(Corynebacterium
glutamicum)
PF00498
(FHA)
3 GLY A 105
LEU A 107
HIS A  89
None
TPO  A  15 ( 2.5A)
None
0.64A 5u63A-2kb3A:
undetectable
5u63A-2kb3A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kl2 AIG2-LIKE
DOMAIN-CONTAINING
PROTEIN 1


(Mus musculus)
PF06094
(GGACT)
3 GLY A 140
LEU A 141
HIS A 139
None
0.65A 5u63A-2kl2A:
undetectable
5u63A-2kl2A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2msv MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN


(Homo sapiens)
no annotation 3 GLY A  32
LEU A  36
HIS A  15
None
0.62A 5u63A-2msvA:
undetectable
5u63A-2msvA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2om5 CONTACTIN 2

(Homo sapiens)
PF07679
(I-set)
PF13927
(Ig_3)
3 GLY A 133
LEU A 134
HIS A 130
None
0.70A 5u63A-2om5A:
undetectable
5u63A-2om5A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtn NICOTINATE
(NICOTINAMIDE)
NUCLEOTIDE
ADENYLYLTRANSFERASE


(Bacillus
anthracis)
PF01467
(CTP_transf_like)
3 GLY A   5
LEU A  31
HIS A 102
None
0.71A 5u63A-2qtnA:
undetectable
5u63A-2qtnA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE


(Neisseria
gonorrhoeae)
PF00583
(Acetyltransf_1)
PF00696
(AA_kinase)
3 GLY A  32
LEU A  35
HIS A  61
None
0.45A 5u63A-2r98A:
undetectable
5u63A-2r98A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN


(Azospirillum
brasilense)
PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central)
3 GLY A1283
LEU A1259
HIS A1263
None
0.71A 5u63A-2vdcA:
undetectable
5u63A-2vdcA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vw8 PA1000

(Pseudomonas
aeruginosa)
PF00753
(Lactamase_B)
3 GLY A 146
LEU A  29
HIS A 149
None
0.58A 5u63A-2vw8A:
undetectable
5u63A-2vw8A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk8 CAI-1 AUTOINDUCER
SYNTHASE


(Vibrio cholerae)
PF00155
(Aminotran_1_2)
3 GLY A 216
LEU A 217
HIS A 210
None
0.58A 5u63A-2wk8A:
undetectable
5u63A-2wk8A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE


(Bacillus
subtilis)
PF00202
(Aminotran_3)
3 GLY A 147
LEU A 152
HIS A 146
PMP  A 431 ( 3.7A)
None
None
0.63A 5u63A-3bs8A:
undetectable
5u63A-3bs8A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3btu GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80


(Saccharomyces
cerevisiae)
PF01408
(GFO_IDH_MocA)
3 GLY A 152
LEU A 150
HIS A 213
None
0.69A 5u63A-3btuA:
3.0
5u63A-3btuA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80


(Kluyveromyces
lactis)
PF01408
(GFO_IDH_MocA)
3 GLY A 153
LEU A 151
HIS A 214
None
0.66A 5u63A-3e1kA:
3.1
5u63A-3e1kA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e73 LANC-LIKE PROTEIN 1

(Homo sapiens)
PF05147
(LANC_like)
3 GLY A 324
LEU A 315
HIS A 274
None
None
GSH  A 502 (-4.0A)
0.70A 5u63A-3e73A:
undetectable
5u63A-3e73A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqq BENZENE
1,2-DIOXYGENASE
SUBUNIT ALPHA


(Pseudomonas
putida)
PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A)
3 GLY A 304
LEU A 298
HIS A 185
None
0.69A 5u63A-3eqqA:
undetectable
5u63A-3eqqA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fge PUTATIVE FLAVIN
REDUCTASE WITH SPLIT
BARREL DOMAIN


(Shewanella
frigidimarina)
PF01613
(Flavin_Reduct)
3 GLY A 184
LEU A 185
HIS A  18
None
0.68A 5u63A-3fgeA:
undetectable
5u63A-3fgeA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fh2 PROBABLE
ATP-DEPENDENT
PROTEASE (HEAT SHOCK
PROTEIN)


(Corynebacterium
glutamicum)
PF02861
(Clp_N)
3 GLY A  36
LEU A  15
HIS A  39
None
0.63A 5u63A-3fh2A:
undetectable
5u63A-3fh2A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE


(Clostridium
acetobutylicum)
PF00155
(Aminotran_1_2)
3 GLY A 159
LEU A 160
HIS A 296
None
0.43A 5u63A-3ftbA:
2.3
5u63A-3ftbA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2i ESTERASE

(Xanthomonas
oryzae)
PF03583
(LIP)
3 GLY A 127
LEU A 128
HIS A 136
None
0.49A 5u63A-3h2iA:
1.6
5u63A-3h2iA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib3 COCE/NOND FAMILY
HYDROLASE


(Staphylococcus
aureus)
PF02129
(Peptidase_S15)
PF08530
(PepX_C)
3 GLY A 206
LEU A 457
HIS A 476
None
0.65A 5u63A-3ib3A:
undetectable
5u63A-3ib3A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3i CAPSID PROTEIN

(Penicillium
chrysogenum
virus)
no annotation 3 GLY A 468
LEU A 471
HIS A 462
None
0.64A 5u63A-3j3iA:
undetectable
5u63A-3j3iA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k28 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
2


(Bacillus
anthracis)
PF00202
(Aminotran_3)
3 GLY A 147
LEU A 152
HIS A 146
PLP  A 900 (-3.8A)
None
None
0.65A 5u63A-3k28A:
undetectable
5u63A-3k28A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l01 GLGA GLYCOGEN
SYNTHASE


(Pyrococcus
abyssi)
PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5)
3 GLY A   7
LEU A  22
HIS A 127
None
0.70A 5u63A-3l01A:
3.4
5u63A-3l01A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lot UNCHARACTERIZED
PROTEIN


(Archaeoglobus
fulgidus)
PF05853
(BKACE)
3 GLY A 237
LEU A 245
HIS A 202
None
0.61A 5u63A-3lotA:
undetectable
5u63A-3lotA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE


(Ehrlichia
chaffeensis)
PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N)
3 GLY A  10
LEU A 363
HIS A  13
None
0.70A 5u63A-3lp8A:
3.2
5u63A-3lp8A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lps TOPOISOMERASE IV
SUBUNIT B


(Xanthomonas
oryzae)
PF00204
(DNA_gyraseB)
PF02518
(HATPase_c)
3 GLY A 130
LEU A 133
HIS A 123
None
0.50A 5u63A-3lpsA:
undetectable
5u63A-3lpsA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdn GLUTAMINE
AMINOTRANSFERASE
CLASS-II DOMAIN
PROTEIN


(Ruegeria
pomeroyi)
PF13230
(GATase_4)
3 GLY A  80
LEU A  81
HIS A   8
None
0.63A 5u63A-3mdnA:
undetectable
5u63A-3mdnA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml0 PENICILLIN G
ACYLASE, ALPHA
SUBUNIT


(Alcaligenes
faecalis)
PF01804
(Penicil_amidase)
3 GLY A 172
LEU A 175
HIS A 167
None
0.61A 5u63A-3ml0A:
undetectable
5u63A-3ml0A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2e SHIKIMATE KINASE

(Helicobacter
pylori)
PF01202
(SKI)
3 GLY A  92
LEU A  91
HIS A   3
None
0.58A 5u63A-3n2eA:
2.4
5u63A-3n2eA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2t PUTATIVE
OXIDOREDUCTASE


(Gluconobacter
oxydans)
PF00248
(Aldo_ket_red)
3 GLY A  86
LEU A  87
HIS A 130
None
0.65A 5u63A-3n2tA:
undetectable
5u63A-3n2tA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nsw EXCRETORY-SECRETORY
PROTEIN 2


(Ancylostoma
ceylanicum)
no annotation 3 GLY A  91
LEU A  92
HIS A  89
None
0.67A 5u63A-3nswA:
undetectable
5u63A-3nswA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o65 PUTATIVE
ATAXIN-3-LIKE
PROTEIN


(Homo sapiens)
PF02099
(Josephin)
3 GLY A 128
LEU A 179
HIS A 130
None
0.67A 5u63A-3o65A:
undetectable
5u63A-3o65A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr1 PHOSPHOLIPASE C-BETA
(PLC-BETA)


(Doryteuthis
pealeii)
PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like)
3 GLY A 437
LEU A 440
HIS A 433
None
0.66A 5u63A-3qr1A:
undetectable
5u63A-3qr1A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE


(Tenebrio
molitor)
PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29)
3 GLY A 207
LEU A  88
HIS A 175
None
0.70A 5u63A-3qt4A:
undetectable
5u63A-3qt4A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd8 FUMARATE HYDRATASE
CLASS II


(Mycolicibacterium
smegmatis)
PF00206
(Lyase_1)
PF10415
(FumaraseC_C)
3 GLY A 220
LEU A 219
HIS A 146
None
0.68A 5u63A-3rd8A:
undetectable
5u63A-3rd8A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4d LACTOSE
PHOSPHORYLASE


(Cellulomonas
uda)
PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36)
3 GLY A 479
LEU A 480
HIS A 478
None
0.69A 5u63A-3s4dA:
undetectable
5u63A-3s4dA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugm TAL EFFECTOR
AVRBS3/PTHA


(Xanthomonas
oryzae)
PF03377
(TAL_effector)
3 GLY A 593
LEU A 594
HIS A 592
None
0.67A 5u63A-3ugmA:
undetectable
5u63A-3ugmA:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdb PROBABLE
ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT


(Mycobacterium
tuberculosis)
PF02861
(Clp_N)
3 GLY A  36
LEU A  15
HIS A  39
None
0.63A 5u63A-3wdbA:
undetectable
5u63A-3wdbA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwc PHOSPHOLIPASE B-LIKE
1
PHOSPHOLIPASE B-LIKE
1


(Bos taurus;
Bos taurus)
PF04916
(Phospholip_B)
PF04916
(Phospholip_B)
3 GLY B 279
LEU A 193
HIS A 114
None
0.67A 5u63A-4bwcB:
undetectable
5u63A-4bwcB:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezi UNCHARACTERIZED
PROTEIN


(Legionella
pneumophila)
no annotation 3 GLY A 146
LEU A 147
HIS A 155
None
0.48A 5u63A-4eziA:
undetectable
5u63A-4eziA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvf BETA-HEXOSAMINIDASE

(Salmonella
enterica)
PF00933
(Glyco_hydro_3)
3 GLY A  93
LEU A  96
HIS A  88
None
0.70A 5u63A-4gvfA:
undetectable
5u63A-4gvfA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iox TRIPARTITE TERMINASE
SUBUNIT UL15


(Human
alphaherpesvirus
1)
PF02499
(DNA_pack_C)
3 GLY A 522
LEU A 708
HIS A 540
None
0.68A 5u63A-4ioxA:
undetectable
5u63A-4ioxA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0r CRYPTOCHROME-1

(Mus musculus)
PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7)
3 GLY A 250
LEU A 251
HIS A 224
None
0.40A 5u63A-4k0rA:
undetectable
5u63A-4k0rA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN


(Xanthomonas
oryzae)
PF01156
(IU_nuc_hydro)
3 GLY A 149
LEU A 148
HIS A 191
None
0.52A 5u63A-4kl0A:
2.4
5u63A-4kl0A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh1 SORBOSE
DEHYDROGENASE


(Ketogulonicigenium
vulgare)
PF13360
(PQQ_2)
3 GLY A 134
LEU A 129
HIS A  90
None
0.65A 5u63A-4mh1A:
undetectable
5u63A-4mh1A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nql AMSH-LIKE PROTEASE
SST2


(Schizosaccharomyces
pombe)
PF01398
(JAB)
3 GLY A 293
LEU A 334
HIS A 304
None
0.70A 5u63A-4nqlA:
undetectable
5u63A-4nqlA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pne METHYLTRANSFERASE-LI
KE PROTEIN


(Saccharopolyspora
spinosa)
PF08241
(Methyltransf_11)
3 GLY A  43
LEU A  60
HIS A  41
None
None
SAH  A 301 ( 3.6A)
0.62A 5u63A-4pneA:
2.2
5u63A-4pneA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmh LP04448P

(Drosophila
melanogaster)
PF12348
(CLASP_N)
3 GLY A1047
LEU A1006
HIS A1051
None
0.61A 5u63A-4qmhA:
undetectable
5u63A-4qmhA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qq2 C1Q-RELATED FACTOR

(Mus musculus)
PF00386
(C1q)
3 GLY A 120
LEU A  15
HIS A  19
None
0.70A 5u63A-4qq2A:
undetectable
5u63A-4qq2A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qri HYPOXANTHINE-GUANINE
-XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE


(Leptospira
interrogans)
PF00156
(Pribosyltran)
3 GLY A 156
LEU A 168
HIS A 172
None
0.63A 5u63A-4qriA:
undetectable
5u63A-4qriA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ric FANCONI-ASSOCIATED
NUCLEASE 1


(Homo sapiens)
PF08774
(VRR_NUC)
3 GLY A 741
LEU A 744
HIS A 985
None
0.55A 5u63A-4ricA:
undetectable
5u63A-4ricA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqg PUTATIVE
DTDP-D-GLUCOSE 4
6-DEHYDRATASE


(Megavirus
chiliensis)
PF02719
(Polysacc_synt_2)
3 GLY A 256
LEU A 257
HIS A 198
None
0.49A 5u63A-4tqgA:
3.4
5u63A-4tqgA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txg CHITINASE

(Chromobacterium
violaceum)
PF00704
(Glyco_hydro_18)
PF06483
(ChiC)
3 GLY A 732
LEU A 730
HIS A 722
None
0.63A 5u63A-4txgA:
undetectable
5u63A-4txgA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8h CRYPTOCHROME-2

(Mus musculus)
PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7)
3 GLY A 268
LEU A 269
HIS A 242
None
0.56A 5u63A-4u8hA:
undetectable
5u63A-4u8hA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN


(Arabidopsis
thaliana)
PF01565
(FAD_binding_4)
PF08031
(BBE)
3 GLY A 183
LEU A 182
HIS A 115
FAD  A 601 (-3.6A)
FAD  A 601 (-4.5A)
FAD  A 601 (-2.5A)
0.58A 5u63A-4ud8A:
undetectable
5u63A-4ud8A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA


(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe)
PF01008
(IF-2B)
PF01008
(IF-2B)
3 GLY G 414
LEU G 416
HIS C 243
None
0.71A 5u63A-5b04G:
undetectable
5u63A-5b04G:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bjx WLAL PROTEIN

(Campylobacter
jejuni)
no annotation 3 GLY A 521
LEU A 522
HIS A 459
None
0.68A 5u63A-5bjxA:
4.2
5u63A-5bjxA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu9 BETA-N-ACETYLHEXOSAM
INIDASE


(Beutenbergia
cavernae)
PF00933
(Glyco_hydro_3)
3 GLY A 256
LEU A 257
HIS A 253
None
None
GOL  A 501 (-3.8A)
0.68A 5u63A-5bu9A:
undetectable
5u63A-5bu9A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cj5 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE


(Mycolicibacterium
thermoresistibile)
PF00128
(Alpha-amylase)
PF11896
(DUF3416)
3 GLY A  53
LEU A 113
HIS A  52
None
0.66A 5u63A-5cj5A:
undetectable
5u63A-5cj5A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck3 SRX DOMAIN
PUTATIVE SIGNAL
RECOGNITION PARTICLE
PROTEIN


(Chaetomium
thermophilum;
Chaetomium
thermophilum)
PF04086
(SRP-alpha_N)
PF09439
(SRPRB)
3 GLY A  13
LEU A   9
HIS B 105
MG  B 401 ( 4.5A)
None
None
0.69A 5u63A-5ck3A:
undetectable
5u63A-5ck3A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cww NUCLEOPORIN NUP82

(Chaetomium
thermophilum)
no annotation 3 GLY B 435
LEU B 479
HIS B 506
None
0.64A 5u63A-5cwwB:
undetectable
5u63A-5cwwB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6p PLEXIN-B2

(Mus musculus)
PF08337
(Plexin_cytopl)
3 GLY A1364
LEU A1366
HIS A1363
None
0.71A 5u63A-5e6pA:
undetectable
5u63A-5e6pA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4i PHOSPHOLYASE

(Paenarthrobacter
aurescens)
PF00202
(Aminotran_3)
3 GLY A 211
LEU A 205
HIS A 210
None
0.70A 5u63A-5g4iA:
undetectable
5u63A-5g4iA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gt2 PROBABLE
DEFERROCHELATASE/PER
OXIDASE YFEX


(Escherichia
coli)
PF04261
(Dyp_perox)
3 GLY A 246
LEU A 139
HIS A 245
None
0.68A 5u63A-5gt2A:
undetectable
5u63A-5gt2A:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gt5 PECTATE LYASE

(Paenibacillus
sp. 0602)
no annotation 3 GLY A  90
LEU A  86
HIS A 114
None
0.62A 5u63A-5gt5A:
undetectable
5u63A-5gt5A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5d INNER MEMBRANE
PROTEIN YEJM


(Salmonella
enterica)
PF00884
(Sulfatase)
PF11893
(DUF3413)
3 GLY A 308
LEU A 309
HIS A 491
None
0.64A 5u63A-5i5dA:
undetectable
5u63A-5i5dA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5h INNER MEMBRANE
PROTEIN YEJM


(Escherichia
coli)
PF00884
(Sulfatase)
PF11893
(DUF3413)
3 GLY A 308
LEU A 309
HIS A 491
None
0.65A 5u63A-5i5hA:
undetectable
5u63A-5i5hA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz3 PREDICTED PROTEIN

(Physcomitrella
patens)
PF00316
(FBPase)
3 GLY B  81
LEU B  80
HIS B 249
None
0.70A 5u63A-5iz3B:
undetectable
5u63A-5iz3B:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0l GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY


(Clostridioides
difficile)
no annotation 3 GLY A 106
LEU A 108
HIS A 105
None
0.67A 5u63A-5n0lA:
undetectable
5u63A-5n0lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nko RIBOSOME HIBERNATION
PROMOTION FACTOR


(Staphylococcus
aureus)
PF16321
(Ribosom_S30AE_C)
3 GLY A 157
LEU A 156
HIS A 158
None
0.67A 5u63A-5nkoA:
undetectable
5u63A-5nkoA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5x CRYPTOCHROME-1

(Mus musculus)
PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7)
3 GLY A 250
LEU A 251
HIS A 224
None
0.46A 5u63A-5t5xA:
undetectable
5u63A-5t5xA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA


(Mycolicibacterium
smegmatis)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45)
3 GLY C 920
LEU C 923
HIS C 590
None
0.65A 5u63A-5tw1C:
undetectable
5u63A-5tw1C:
14.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u63 THIOREDOXIN
REDUCTASE


(Haemophilus
influenzae)
PF07992
(Pyr_redox_2)
3 GLY A  37
LEU A  38
HIS A  84
FAD  A 401 ( 3.1A)
ACT  A 405 ( 3.6A)
ACT  A 405 ( 3.9A)
0.05A 5u63A-5u63A:
53.2
5u63A-5u63A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uy3 ANTIBODY PGT144 FAB
HEAVY CHAIN


(Homo sapiens)
no annotation 3 GLY H  94
LEU H 105
HIS H  35
None
0.61A 5u63A-5uy3H:
undetectable
5u63A-5uy3H:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT


(Desulfovibrio
gigas)
no annotation 3 GLY A 189
LEU A 386
HIS A 186
None
0.66A 5u63A-5xmjA:
14.5
5u63A-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqo PCRGLX PROTEIN

(Penicillium
chrysogenum)
no annotation 3 GLY A  47
LEU A  48
HIS A  92
None
0.59A 5u63A-5xqoA:
undetectable
5u63A-5xqoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ar2 SARCOLEMMAL
MEMBRANE-ASSOCIATED
PROTEIN


(Homo sapiens)
no annotation 3 GLY A  31
LEU A  51
HIS A  55
None
0.70A 5u63A-6ar2A:
undetectable
5u63A-6ar2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blg DTDP-4-AMINO-4,6-DID
EOXYGALACTOSE
TRANSAMINASE


(Klebsiella
pneumoniae)
no annotation 3 GLY A 156
LEU A 166
HIS A 127
None
0.68A 5u63A-6blgA:
undetectable
5u63A-6blgA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH13 NADH
DEHYDROGENASE
SUBUNIT


(Pyrococcus
furiosus)
no annotation 3 GLY M 159
LEU M 158
HIS M 172
None
0.64A 5u63A-6cfwM:
undetectable
5u63A-6cfwM:
undetectable