SIMILAR PATTERNS OF AMINO ACIDS FOR 5U4S_B_BEZB301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cfr RESTRICTION
ENDONUCLEASE

(Citrobacter
freundii) 		PF07832
(Bse634I) 		4 ILE A 140
LEU A 147
MET A 150
LEU A 151
 None
 0.95A 5u4sB-1cfrA:
2.5		 5u4sB-1cfrA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7o 4-HYDROXYPHENYLACETA
TE DEGRADATION
BIFUNCTIONAL
ISOMERASE/DECARBOXYL
ASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		4 ASN A  43
ILE A 283
LEU A 385
MET A 383
 None
 1.00A 5u4sB-1i7oA:
undetectable		 5u4sB-1i7oA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jeq KU70

(Homo sapiens) 		PF02037
(SAP)
PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N) 		4 SER A 257
ILE A 273
LEU A 256
PRO A 402
 None
 0.90A 5u4sB-1jeqA:
3.8		 5u4sB-1jeqA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhn CALNEXIN

(Canis lupus) 		PF00262
(Calreticulin) 		4 SER A 133
ILE A  85
LEU A 177
LEU A 169
 None
 1.03A 5u4sB-1jhnA:
undetectable		 5u4sB-1jhnA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jy2 FIBRINOGEN ALPHA
CHAIN
FIBRINOGEN GAMMA-B
CHAIN

(Bos taurus;
Bos taurus) 		PF08702
(Fib_alpha)
PF08702
(Fib_alpha) 		4 ASN N  45
ILE P  25
PRO N  49
MET N  54
 None
 0.82A 5u4sB-1jy2N:
undetectable		 5u4sB-1jy2N:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN ALPHA
SUBUNIT
FIBRINOGEN BETA
CHAIN
FIBRINOGEN GAMMA
CHAIN

(Gallus gallus;
Gallus gallus;
Gallus gallus) 		PF08702
(Fib_alpha)
PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha)
PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		4 ASN B 148
ILE C  90
LEU A 116
MET B 151
 None
 1.07A 5u4sB-1m1jB:
undetectable		 5u4sB-1m1jB:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m22 PEPTIDE AMIDASE

(Stenotrophomonas
maltophilia) 		PF01425
(Amidase) 		4 SER A 255
ILE A 254
LEU A 363
LEU A 362
 None
 1.05A 5u4sB-1m22A:
undetectable		 5u4sB-1m22A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tnd TRANSDUCIN

(Bos taurus) 		PF00503
(G-alpha) 		4 ILE A 220
LEU A  34
MET A 194
LEU A  32
 None
 0.93A 5u4sB-1tndA:
2.5		 5u4sB-1tndA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8b ADENOSYLHOMOCYSTEINA
SE

(Plasmodium
falciparum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 SER A 256
ILE A 255
LEU A 279
MET A 248
 None
 0.83A 5u4sB-1v8bA:
7.9		 5u4sB-1v8bA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcb PROTEIN (ELONGIN C)

(Homo sapiens) 		PF03931
(Skp1_POZ) 		4 SER B  39
ILE B  42
LEU B 110
MET B  45
 None
 1.08A 5u4sB-1vcbB:
undetectable		 5u4sB-1vcbB:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgq FORMYL-COENZYME A
TRANSFERASE

(Oxalobacter
formigenes) 		PF02515
(CoA_transf_3) 		4 ILE A  87
LEU A  83
MET A  74
LEU A  72
 None
None
CAO  A 429 (-4.5A)
None
 1.06A 5u4sB-1vgqA:
6.2		 5u4sB-1vgqA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wgw 'SIGNAL RECOGNITION
PARTICLE 54

(Mus musculus) 		PF02881
(SRP54_N) 		4 ILE A  64
LEU A  32
MET A  35
LEU A  36
 None
 0.94A 5u4sB-1wgwA:
undetectable		 5u4sB-1wgwA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y56 HYPOTHETICAL PROTEIN
PH1363

(Pyrococcus
horikoshii) 		PF07992
(Pyr_redox_2)
PF13510
(Fer2_4) 		4 LEU A 165
LEU A 123
PRO A 116
MET A 144
 None
None
ATP  A 801 (-3.3A)
None
 1.01A 5u4sB-1y56A:
3.2		 5u4sB-1y56A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yhu HEMOGLOBIN B2 CHAIN

(Riftia
pachyptila) 		PF00042
(Globin) 		4 SER D  77
ILE D  78
LEU D  74
MET D  12
 HEM  D 160 ( 4.7A)
None
HEM  D 160 (-3.7A)
None
 0.64A 5u4sB-1yhuD:
undetectable		 5u4sB-1yhuD:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a45 FIBRINOGEN ALPHA
CHAIN
FIBRINOGEN GAMMA
CHAIN

(Homo sapiens;
Homo sapiens) 		PF08702
(Fib_alpha)
PF08702
(Fib_alpha) 		4 ASN G  42
ILE I  25
PRO G  46
MET G  51
 None
 0.95A 5u4sB-2a45G:
undetectable		 5u4sB-2a45G:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpg GLUCOSE 6-PHOSPHATE
DEHYDROGENASE

(Leuconostoc
mesenteroides) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		4 ASN A 142
ILE A 126
LEU A 130
LEU A 136
 None
 0.93A 5u4sB-2dpgA:
3.7		 5u4sB-2dpgA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hb6 LEUCINE
AMINOPEPTIDASE 1

(Caenorhabditis
elegans) 		PF00883
(Peptidase_M17) 		4 ILE A 441
LEU A 440
MET A 421
LEU A 414
 None
 1.06A 5u4sB-2hb6A:
2.0		 5u4sB-2hb6A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kn6 APOPTOSIS-ASSOCIATED
SPECK-LIKE PROTEIN
CONTAINING A CARD

(Homo sapiens) 		PF00619
(CARD)
PF02758
(PYRIN) 		4 ILE A 123
LEU A 122
LEU A 188
MET A 159
 None
 0.87A 5u4sB-2kn6A:
undetectable		 5u4sB-2kn6A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l9j MATRIX PROTEIN 2-1

(Human
orthopneumovirus) 		PF06436
(Pneumovirus_M2) 		4 ILE A 135
LEU A 103
MET A  99
LEU A 102
 None
 0.93A 5u4sB-2l9jA:
undetectable		 5u4sB-2l9jA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lrn THIOL:DISULFIDE
INTERCHANGE PROTEIN

(Bacteroides sp.
4_3_47FAA) 		PF00578
(AhpC-TSA) 		4 SER A   7
ILE A 122
LEU A   3
PRO A  10
 None
 0.97A 5u4sB-2lrnA:
2.0		 5u4sB-2lrnA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2myg DITHIOL GLUTAREDOXIN
1

(Trypanosoma
brucei) 		PF00462
(Glutaredoxin) 		4 ILE A   6
LEU A  54
MET A  48
MET A   9
 None
 1.01A 5u4sB-2mygA:
undetectable		 5u4sB-2mygA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00106
(adh_short) 		4 ASN A  85
ILE A 211
LEU A 137
PRO A 213
 None
 1.00A 5u4sB-2nwqA:
25.2		 5u4sB-2nwqA:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16918
(PknG_TPR)
PF16919
(PknG_rubred) 		4 ILE A 260
LEU A 261
MET A 388
LEU A 392
 None
 0.90A 5u4sB-2pziA:
undetectable		 5u4sB-2pziA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfa TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6

(Mus musculus) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		4 ILE A 189
LEU A 219
MET A 215
LEU A 218
 None
 1.08A 5u4sB-2rfaA:
undetectable		 5u4sB-2rfaA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uye REGULATORY PROTEIN

(Burkholderia
cepacia) 		PF03466
(LysR_substrate) 		4 ILE A 235
LEU A 236
MET A 174
LEU A 259
 None
 0.93A 5u4sB-2uyeA:
undetectable		 5u4sB-2uyeA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v3c SIGNAL RECOGNITION
54 KDA PROTEIN

(Methanocaldococcus
jannaschii) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		4 ILE C 108
LEU C 199
MET C 203
LEU C 200
 None
 0.98A 5u4sB-2v3cC:
2.3		 5u4sB-2v3cC:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		4 ILE A 402
LEU A 403
LEU A 423
PRO A 383
 None
 1.02A 5u4sB-2wzsA:
undetectable		 5u4sB-2wzsA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yrb PROTEIN FANTOM

(Homo sapiens) 		PF11618
(C2-C2_1) 		4 SER A 707
ILE A 703
LEU A 735
LEU A 600
 None
 1.07A 5u4sB-2yrbA:
undetectable		 5u4sB-2yrbA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermotoga
maritima) 		PF01425
(Amidase) 		4 SER A 304
ILE A 344
LEU A 351
PRO A 300
 None
 1.09A 5u4sB-3al0A:
undetectable		 5u4sB-3al0A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdz P450CIN

(Citrobacter
braakii) 		PF00067
(p450) 		4 ILE A 234
LEU A 235
LEU A 157
MET A  90
 HEM  A 450 (-4.7A)
None
None
HEM  A 450 (-4.6A)
 0.98A 5u4sB-3bdzA:
undetectable		 5u4sB-3bdzA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cg1 UPF0100 PROTEIN
PF0080

(Pyrococcus
furiosus) 		PF13531
(SBP_bac_11) 		4 ILE A 144
LEU A 145
LEU A 185
MET A 134
 None
 0.86A 5u4sB-3cg1A:
undetectable		 5u4sB-3cg1A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cg3 UPF0100 PROTEIN
PH0151

(Pyrococcus
horikoshii) 		PF13531
(SBP_bac_11) 		4 ILE A 139
LEU A 140
LEU A 180
MET A 129
 None
 0.80A 5u4sB-3cg3A:
undetectable		 5u4sB-3cg3A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckm YRAM (HI1655)

(Haemophilus
influenzae) 		PF04348
(LppC) 		4 ILE A 276
LEU A 320
LEU A 321
MET A 519
 None
 1.01A 5u4sB-3ckmA:
2.1		 5u4sB-3ckmA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6n DIHYDROOROTASE

(Aquifex
aeolicus) 		PF01979
(Amidohydro_1) 		4 ILE A 219
LEU A 220
MET A 163
LEU A 167
 None
 0.93A 5u4sB-3d6nA:
3.2		 5u4sB-3d6nA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9a 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Vibrio cholerae) 		PF00793
(DAHP_synth_1) 		4 ILE A 233
LEU A 229
MET A 267
LEU A 270
 None
 1.08A 5u4sB-3e9aA:
undetectable		 5u4sB-3e9aA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g87 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Burkholderia
pseudomallei) 		PF00698
(Acyl_transf_1) 		4 ILE A  44
LEU A  47
LEU A  56
PRO A  64
 None
 0.91A 5u4sB-3g87A:
undetectable		 5u4sB-3g87A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gpi NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Methylobacillus
flagellatus) 		PF13460
(NAD_binding_10) 		4 ASN A 249
ILE A 260
LEU A 252
PRO A 262
 None
 1.05A 5u4sB-3gpiA:
14.9		 5u4sB-3gpiA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 15

(Thermus
thermophilus) 		PF11497
(NADH_Oxid_Nqo15) 		4 ILE 7  82
LEU 7  16
MET 7  20
LEU 7  17
 None
 0.99A 5u4sB-3i9v7:
undetectable		 5u4sB-3i9v7:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN

(Namalycastis
sp. ST01) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 ILE A 291
LEU A 288
LEU A 353
PRO A 295
 None
 1.03A 5u4sB-3l2eA:
undetectable		 5u4sB-3l2eA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m03 ORIGIN RECOGNITION
COMPLEX SUBUNIT 6

(Homo sapiens) 		no annotation 4 ILE A  96
LEU A 101
LEU A 145
PRO A 138
 None
None
None
MES  A   1 (-3.5A)
 1.02A 5u4sB-3m03A:
undetectable		 5u4sB-3m03A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6i L-ARABINITOL
4-DEHYDROGENASE

(Neurospora
crassa) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ILE A 355
LEU A 193
MET A 196
LEU A 197
 None
 0.92A 5u4sB-3m6iA:
9.2		 5u4sB-3m6iA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		4 SER A 380
ILE A 381
LEU A 377
LEU A 352
 None
 0.95A 5u4sB-3na0A:
undetectable		 5u4sB-3na0A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz4 PHENYLALANINE
AMMONIA-LYASE

(Taxus
canadensis) 		PF00221
(Lyase_aromatic) 		4 ILE A 185
LEU A 188
LEU A 211
MET A 133
 None
 1.00A 5u4sB-3nz4A:
undetectable		 5u4sB-3nz4A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 ILE B 250
LEU B 246
MET B 291
LEU B 241
 None
 0.74A 5u4sB-3ohmB:
undetectable		 5u4sB-3ohmB:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3okz PUTATIVE
UNCHARACTERIZED
PROTEIN GBS0355

(Streptococcus
agalactiae) 		PF03816
(LytR_cpsA_psr) 		4 SER A 209
LEU A 206
MET A 157
LEU A 160
 None
 0.98A 5u4sB-3okzA:
undetectable		 5u4sB-3okzA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pt3 E3 UBIQUITIN-PROTEIN
LIGASE UBR5

(Homo sapiens) 		PF00632
(HECT) 		4 ASN A2703
SER A2700
ILE A2754
LEU A2776
 None
 0.99A 5u4sB-3pt3A:
undetectable		 5u4sB-3pt3A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pua PHD FINGER PROTEIN 2

(Homo sapiens) 		PF02373
(JmjC) 		4 ILE A 401
LEU A 402
MET A 373
LEU A 377
 None
 0.95A 5u4sB-3puaA:
undetectable		 5u4sB-3puaA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbw ANHYDRO-N-ACETYLMURA
MIC ACID KINASE

(Pseudomonas
aeruginosa) 		PF03702
(AnmK) 		4 SER A  93
ILE A  91
LEU A   7
MET A  16
 None
 0.98A 5u4sB-3qbwA:
undetectable		 5u4sB-3qbwA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t0q AGR253WP

(Eremothecium
gossypii) 		PF00225
(Kinesin) 		4 SER A 441
ILE A 588
LEU A 442
MET A 494
 None
 0.94A 5u4sB-3t0qA:
undetectable		 5u4sB-3t0qA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Hoeflea
phototrophica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 259
LEU A 299
LEU A 300
PRO A 257
 None
 0.90A 5u4sB-3t8qA:
2.3		 5u4sB-3t8qA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcs RACEMASE, PUTATIVE

(Roseobacter
denitrificans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 259
LEU A 299
LEU A 300
PRO A 257
 None
 0.91A 5u4sB-3tcsA:
undetectable		 5u4sB-3tcsA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Roseovarius
nubinhibens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 259
LEU A 299
LEU A 300
PRO A 257
 None
 0.90A 5u4sB-3u4fA:
undetectable		 5u4sB-3u4fA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uet ALPHA-1,3/4-FUCOSIDA
SE

(Bifidobacterium
longum) 		PF01120
(Alpha_L_fucos) 		4 ILE A 286
LEU A 322
MET A  31
LEU A 320
 None
 1.04A 5u4sB-3uetA:
undetectable		 5u4sB-3uetA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7n THREONINE SYNTHASE

(Burkholderia
thailandensis) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 ASN A 259
ILE A 288
LEU A 286
LEU A  45
 None
 0.89A 5u4sB-3v7nA:
2.1		 5u4sB-3v7nA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpo RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2

(Homo sapiens) 		PF00268
(Ribonuc_red_sm) 		4 ILE A 313
LEU A 246
MET A 252
LEU A 255
 None
 0.92A 5u4sB-3vpoA:
undetectable		 5u4sB-3vpoA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vqi ATG5

(Kluyveromyces
marxianus) 		PF04106
(APG5) 		4 SER A 228
ILE A 229
LEU A 225
LEU A 220
 None
 0.82A 5u4sB-3vqiA:
undetectable		 5u4sB-3vqiA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiq KOJIBIOSE
PHOSPHORYLASE

(Caldicellulosiruptor
saccharolyticus) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 SER A 450
ILE A 453
LEU A 508
LEU A 512
 None
 0.99A 5u4sB-3wiqA:
undetectable		 5u4sB-3wiqA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Caenorhabditis
elegans) 		PF13649
(Methyltransf_25) 		4 ILE A  37
LEU A  77
MET A  81
LEU A  78
 None
None
None
SAH  A 701 (-3.9A)
 0.79A 5u4sB-3wstA:
5.1		 5u4sB-3wstA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8a GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
POLY(A) RIBONUCLEASE
POP2

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF16415
(CNOT1_CAF1_bind)
PF04857
(CAF1) 		4 ASN A 952
ILE B 171
LEU B 174
MET B 146
 None
 1.07A 5u4sB-4b8aA:
undetectable		 5u4sB-4b8aA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli) 		PF05175
(MTS) 		4 ASN A 206
SER A  99
ILE A  70
LEU A 120
 None
 0.97A 5u4sB-4dcmA:
6.0		 5u4sB-4dcmA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwq TRNA-SPLICING LIGASE
RTCB

(Pyrococcus
horikoshii) 		PF01139
(RtcB) 		4 SER A 270
ILE A 256
LEU A  53
PRO A 272
 None
 1.08A 5u4sB-4dwqA:
undetectable		 5u4sB-4dwqA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1j GLYCEROL KINASE

(Sinorhizobium
meliloti) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 ILE A 327
LEU A 412
MET A 416
LEU A 413
 None
 1.04A 5u4sB-4e1jA:
undetectable		 5u4sB-4e1jA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnk 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 ILE B 250
LEU B 246
MET B 291
LEU B 241
 None
 0.83A 5u4sB-4gnkB:
undetectable		 5u4sB-4gnkB:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h40 PUTATIVE CELL
ADHESION PROTEIN

(Bacteroides
fragilis) 		PF15415
(Mfa_like_2) 		4 ILE A  37
LEU A 193
LEU A 195
MET A 131
 None
 0.75A 5u4sB-4h40A:
undetectable		 5u4sB-4h40A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iuw NEUTRAL
ENDOPEPTIDASE

(Lactobacillus
rhamnosus) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		4 ILE A 117
LEU A 251
LEU A 214
PRO A 229
 None
 1.06A 5u4sB-4iuwA:
undetectable		 5u4sB-4iuwA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgl HYPOTHETICAL PROTEIN

(Bacteroides
eggerthii) 		no annotation 4 ILE A  89
LEU A  78
MET A  71
LEU A  76
 None
 0.99A 5u4sB-4jglA:
undetectable		 5u4sB-4jglA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3z D-ERYTHRULOSE
4-PHOSPHATE
DEHYDROGENASE

(Brucella
melitensis) 		no annotation 4 ILE A 105
LEU A 108
MET A  58
LEU A  62
 None
 0.91A 5u4sB-4k3zA:
undetectable		 5u4sB-4k3zA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf6 GLYCOLIPID TRANSFER
PROTEIN
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF08718
(GLTP) 		4 ILE A  33
LEU A  29
MET A  82
LEU A  79
 None
 0.66A 5u4sB-4kf6A:
undetectable		 5u4sB-4kf6A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mm0 P450-LIKE
MONOOXYGENASE

(Streptomyces
griseoviridis) 		PF00067
(p450) 		4 ILE A 229
LEU A 230
LEU A 150
MET A  83
 None
None
None
HEM  A 401 (-4.2A)
 0.89A 5u4sB-4mm0A:
undetectable		 5u4sB-4mm0A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmq FUSION GLYCOPROTEIN
F1 FUSED WITH
FIBRITIN
TRIMERIZATION DOMAIN

(Escherichia
virus T4;
Human
orthopneumovirus) 		PF00523
(Fusion_gly) 		4 ILE B 261
LEU B 257
LEU B 252
PRO B 304
 None
 0.81A 5u4sB-4mmqB:
undetectable		 5u4sB-4mmqB:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwa 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE

(Bacillus
anthracis) 		PF04551
(GcpE) 		4 SER D 218
ILE D 205
LEU D 222
LEU D 252
 None
 0.96A 5u4sB-4mwaD:
2.1		 5u4sB-4mwaD:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E

(Butyrivibrio
proteoclasticus) 		PF04616
(Glyco_hydro_43) 		4 ASN A 257
ILE A 261
MET A 248
LEU A 229
 None
 1.08A 5u4sB-4novA:
undetectable		 5u4sB-4novA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Xanthobacter
autotrophicus) 		PF03480
(DctP) 		4 ILE A 156
LEU A 162
MET A 179
LEU A 182
 None
 0.99A 5u4sB-4ovrA:
undetectable		 5u4sB-4ovrA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpj CELL CYCLE RESPONSE
REGULATOR CTRA

(Brucella
abortus) 		PF00072
(Response_reg) 		4 ILE C  47
LEU C  76
MET C  99
LEU C  78
 None
 0.82A 5u4sB-4qpjC:
7.4		 5u4sB-4qpjC:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgl FILAMENTATION
INDUCED BY CAMP
PROTEIN FIC

(Desulfovibrio
alaskensis) 		PF02661
(Fic) 		4 SER A 171
ILE A 199
LEU A 247
PRO A 167
 None
 1.05A 5u4sB-4rglA:
undetectable		 5u4sB-4rglA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umz CYTOCHROME P450
HYDROXYLASE PIKC

(Streptomyces
venezuelae) 		PF00067
(p450) 		4 ILE A 239
LEU A 240
LEU A 161
MET A  92
 HEM  A1407 ( 4.9A)
None
None
HEM  A1407 (-3.8A)
 1.08A 5u4sB-4umzA:
undetectable		 5u4sB-4umzA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 ILE A 238
LEU A 239
MET A 264
LEU A 262
 None
None
ANW  A 601 (-3.2A)
None
 0.92A 5u4sB-4wboA:
undetectable		 5u4sB-4wboA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xa9 GALA PROTEIN TYPE 1,
3 OR 4

(Legionella
pneumophila) 		PF13516
(LRR_6) 		4 ASN A 243
ILE A 228
LEU A 229
LEU A 240
 None
 0.97A 5u4sB-4xa9A:
undetectable		 5u4sB-4xa9A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvm DNA POLYMERASE NU

(Homo sapiens) 		PF00476
(DNA_pol_A) 		4 ILE A 356
LEU A 420
LEU A 423
PRO A 358
 None
 0.94A 5u4sB-4xvmA:
undetectable		 5u4sB-4xvmA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye5 PEPTIDOGLYCAN
SYNTHETASE
PENICILLIN-BINDING
PROTEIN 3

(Bifidobacterium
adolescentis) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 ILE A  87
LEU A 153
LEU A 129
PRO A  90
 None
 0.98A 5u4sB-4ye5A:
undetectable		 5u4sB-4ye5A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  66
LEU A  67
MET A  92
LEU A  90
 None
None
51W  A 401 (-3.9A)
None
 1.05A 5u4sB-5ci7A:
undetectable		 5u4sB-5ci7A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz6 POLYKETIDE
BIOSYNTHESIS MALONYL
COA-ACYL CARRIER
PROTEIN TRANSACYLASE
PKSC

(Bacillus
subtilis) 		PF00698
(Acyl_transf_1) 		4 ILE A  39
LEU A  42
LEU A  51
PRO A  59
 None
 0.86A 5u4sB-5dz6A:
undetectable		 5u4sB-5dz6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE

(Pyrococcus
horikoshii) 		PF00004
(AAA) 		4 ILE A 211
LEU A 233
MET A 237
LEU A 234
 None
 1.07A 5u4sB-5eqtA:
undetectable		 5u4sB-5eqtA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		4 ILE A 478
LEU A 489
MET A 508
LEU A 487
 None
 1.02A 5u4sB-5h42A:
undetectable		 5u4sB-5h42A:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig5 CAMKII-B HUB

(Nematostella
vectensis) 		PF08332
(CaMKII_AD) 		4 SER A 360
ILE A 361
LEU A 357
LEU A 372
 None
 1.02A 5u4sB-5ig5A:
undetectable		 5u4sB-5ig5A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l22 ABC TRANSPORTER
(HLYB SUBFAMILY)

(Aquifex
aeolicus) 		no annotation 4 ILE B 137
LEU B 134
MET B  84
LEU B 129
 None
 1.08A 5u4sB-5l22B:
undetectable		 5u4sB-5l22B:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lb7 KATANIN P80 WD40
REPEAT-CONTAINING
SUBUNIT B1

(Mus musculus) 		PF13925
(Katanin_con80) 		4 ILE A 588
LEU A 589
MET A 654
LEU A 653
 None
 0.91A 5u4sB-5lb7A:
undetectable		 5u4sB-5lb7A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzn HELICASE
SEN1,HELICASE SEN1

(Saccharomyces
cerevisiae) 		PF13086
(AAA_11)
PF13087
(AAA_12) 		4 SER A1600
ILE A1601
LEU A1638
MET A1642
 None
 0.82A 5u4sB-5mznA:
2.1		 5u4sB-5mznA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN

(Tribolium
castaneum) 		no annotation 4 ILE A 253
LEU A 292
MET A 198
LEU A 290
 None
 0.94A 5u4sB-5oatA:
undetectable		 5u4sB-5oatA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		4 SER T2636
ILE T2639
LEU T2640
LEU T2665
 None
 0.97A 5u4sB-5ojsT:
undetectable		 5u4sB-5ojsT:
4.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u4s PUTATIVE SHORT CHAIN
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00106
(adh_short) 		8 ASN A  83
SER A 131
ILE A 132
LEU A 133
MET A 141
LEU A 144
PRO A 176
MET A 215
 BEZ  A 301 (-4.0A)
BEZ  A 301 (-2.6A)
None
BEZ  A 301 (-4.2A)
BEZ  A 301 (-3.5A)
BEZ  A 301 (-4.9A)
BEZ  A 301 ( 4.0A)
BEZ  A 301 ( 4.1A)
 0.14A 5u4sB-5u4sA:
41.8		 5u4sB-5u4sA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1

(Gallus gallus) 		PF03493
(BK_channel_a)
PF07885
(Ion_trans_2) 		4 ILE A1148
LEU A 511
MET A 932
LEU A 929
 None
 0.99A 5u4sB-5u70A:
4.5		 5u4sB-5u70A:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w81 CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Danio rerio) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF14396
(CFTR_R) 		4 ILE A 372
LEU A  70
MET A  74
LEU A  71
 None
 1.06A 5u4sB-5w81A:
undetectable		 5u4sB-5w81A:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wo6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6

(Rattus
norvegicus) 		PF00520
(Ion_trans)
PF12796
(Ank_2)
PF13637
(Ank_4) 		4 ILE A 189
LEU A 219
MET A 215
LEU A 218
 ILE  A 189 ( 0.7A)
LEU  A 219 ( 0.6A)
MET  A 215 ( 0.0A)
LEU  A 218 ( 0.6A)
 1.02A 5u4sB-5wo6A:
undetectable		 5u4sB-5wo6A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1

(Saccharomyces
cerevisiae) 		no annotation 4 ASN C1700
ILE C1666
LEU C1696
PRO C1662
 None
 1.06A 5u4sB-5x6oC:
undetectable		 5u4sB-5x6oC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y05 MSMEG_4306

(Mycolicibacterium
smegmatis) 		no annotation 4 ILE A  72
LEU A 117
MET A 121
LEU A 118
 None
 0.85A 5u4sB-5y05A:
undetectable		 5u4sB-5y05A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
SMALL SUBUNIT
ALDEHYDE OXIDASE
MEDIUM SUBUNIT

(Methylobacillus
sp. KY4400;
Methylobacillus
sp. KY4400) 		no annotation
no annotation 		4 ASN A 136
SER B  99
ILE B 102
MET B 105
 None
None
FAD  B 401 (-4.6A)
None
 1.03A 5u4sB-5y6qA:
undetectable		 5u4sB-5y6qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apg DISD PROTEIN

(Sorangium
cellulosum) 		no annotation 4 ILE A  39
LEU A  42
LEU A  51
PRO A  59
 None
 0.84A 5u4sB-6apgA:
undetectable		 5u4sB-6apgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d7t TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6

(Homo sapiens) 		no annotation 4 ILE A 189
LEU A 219
MET A 215
LEU A 218
 None
 1.04A 5u4sB-6d7tA:
undetectable		 5u4sB-6d7tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN
FACTOR VIII INTRON
22 PROTEIN

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 SER B 324
LEU B 321
LEU B 320
PRO A1996
 None
 0.79A 5u4sB-6ez8B:
undetectable		 5u4sB-6ez8B:
undetectable