SIMILAR PATTERNS OF AMINO ACIDS FOR 5U4S_B_BEZB301_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cfr | RESTRICTIONENDONUCLEASE (Citrobacterfreundii) |
PF07832(Bse634I) | 4 | ILE A 140LEU A 147MET A 150LEU A 151 | None | 0.95A | 5u4sB-1cfrA:2.5 | 5u4sB-1cfrA:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i7o | 4-HYDROXYPHENYLACETATE DEGRADATIONBIFUNCTIONALISOMERASE/DECARBOXYLASE (Escherichiacoli) |
PF01557(FAA_hydrolase) | 4 | ASN A 43ILE A 283LEU A 385MET A 383 | None | 1.00A | 5u4sB-1i7oA:undetectable | 5u4sB-1i7oA:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jeq | KU70 (Homo sapiens) |
PF02037(SAP)PF02735(Ku)PF03730(Ku_C)PF03731(Ku_N) | 4 | SER A 257ILE A 273LEU A 256PRO A 402 | None | 0.90A | 5u4sB-1jeqA:3.8 | 5u4sB-1jeqA:17.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jhn | CALNEXIN (Canis lupus) |
PF00262(Calreticulin) | 4 | SER A 133ILE A 85LEU A 177LEU A 169 | None | 1.03A | 5u4sB-1jhnA:undetectable | 5u4sB-1jhnA:19.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jy2 | FIBRINOGEN ALPHACHAINFIBRINOGEN GAMMA-BCHAIN (Bos taurus;Bos taurus) |
PF08702(Fib_alpha)PF08702(Fib_alpha) | 4 | ASN N 45ILE P 25PRO N 49MET N 54 | None | 0.82A | 5u4sB-1jy2N:undetectable | 5u4sB-1jy2N:10.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m1j | FIBRINOGEN ALPHASUBUNITFIBRINOGEN BETACHAINFIBRINOGEN GAMMACHAIN (Gallus gallus;Gallus gallus;Gallus gallus) |
PF08702(Fib_alpha)PF00147(Fibrinogen_C)PF08702(Fib_alpha)PF00147(Fibrinogen_C)PF08702(Fib_alpha) | 4 | ASN B 148ILE C 90LEU A 116MET B 151 | None | 1.07A | 5u4sB-1m1jB:undetectable | 5u4sB-1m1jB:17.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m22 | PEPTIDE AMIDASE (Stenotrophomonasmaltophilia) |
PF01425(Amidase) | 4 | SER A 255ILE A 254LEU A 363LEU A 362 | None | 1.05A | 5u4sB-1m22A:undetectable | 5u4sB-1m22A:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tnd | TRANSDUCIN (Bos taurus) |
PF00503(G-alpha) | 4 | ILE A 220LEU A 34MET A 194LEU A 32 | None | 0.93A | 5u4sB-1tndA:2.5 | 5u4sB-1tndA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v8b | ADENOSYLHOMOCYSTEINASE (Plasmodiumfalciparum) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | SER A 256ILE A 255LEU A 279MET A 248 | None | 0.83A | 5u4sB-1v8bA:7.9 | 5u4sB-1v8bA:18.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vcb | PROTEIN (ELONGIN C) (Homo sapiens) |
PF03931(Skp1_POZ) | 4 | SER B 39ILE B 42LEU B 110MET B 45 | None | 1.08A | 5u4sB-1vcbB:undetectable | 5u4sB-1vcbB:18.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vgq | FORMYL-COENZYME ATRANSFERASE (Oxalobacterformigenes) |
PF02515(CoA_transf_3) | 4 | ILE A 87LEU A 83MET A 74LEU A 72 | NoneNoneCAO A 429 (-4.5A)None | 1.06A | 5u4sB-1vgqA:6.2 | 5u4sB-1vgqA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wgw | 'SIGNAL RECOGNITIONPARTICLE 54 (Mus musculus) |
PF02881(SRP54_N) | 4 | ILE A 64LEU A 32MET A 35LEU A 36 | None | 0.94A | 5u4sB-1wgwA:undetectable | 5u4sB-1wgwA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y56 | HYPOTHETICAL PROTEINPH1363 (Pyrococcushorikoshii) |
PF07992(Pyr_redox_2)PF13510(Fer2_4) | 4 | LEU A 165LEU A 123PRO A 116MET A 144 | NoneNoneATP A 801 (-3.3A)None | 1.01A | 5u4sB-1y56A:3.2 | 5u4sB-1y56A:18.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yhu | HEMOGLOBIN B2 CHAIN (Riftiapachyptila) |
PF00042(Globin) | 4 | SER D 77ILE D 78LEU D 74MET D 12 | HEM D 160 ( 4.7A)NoneHEM D 160 (-3.7A)None | 0.64A | 5u4sB-1yhuD:undetectable | 5u4sB-1yhuD:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a45 | FIBRINOGEN ALPHACHAINFIBRINOGEN GAMMACHAIN (Homo sapiens;Homo sapiens) |
PF08702(Fib_alpha)PF08702(Fib_alpha) | 4 | ASN G 42ILE I 25PRO G 46MET G 51 | None | 0.95A | 5u4sB-2a45G:undetectable | 5u4sB-2a45G:14.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dpg | GLUCOSE 6-PHOSPHATEDEHYDROGENASE (Leuconostocmesenteroides) |
PF00479(G6PD_N)PF02781(G6PD_C) | 4 | ASN A 142ILE A 126LEU A 130LEU A 136 | None | 0.93A | 5u4sB-2dpgA:3.7 | 5u4sB-2dpgA:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hb6 | LEUCINEAMINOPEPTIDASE 1 (Caenorhabditiselegans) |
PF00883(Peptidase_M17) | 4 | ILE A 441LEU A 440MET A 421LEU A 414 | None | 1.06A | 5u4sB-2hb6A:2.0 | 5u4sB-2hb6A:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kn6 | APOPTOSIS-ASSOCIATEDSPECK-LIKE PROTEINCONTAINING A CARD (Homo sapiens) |
PF00619(CARD)PF02758(PYRIN) | 4 | ILE A 123LEU A 122LEU A 188MET A 159 | None | 0.87A | 5u4sB-2kn6A:undetectable | 5u4sB-2kn6A:24.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2l9j | MATRIX PROTEIN 2-1 (Humanorthopneumovirus) |
PF06436(Pneumovirus_M2) | 4 | ILE A 135LEU A 103MET A 99LEU A 102 | None | 0.93A | 5u4sB-2l9jA:undetectable | 5u4sB-2l9jA:16.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lrn | THIOL:DISULFIDEINTERCHANGE PROTEIN (Bacteroides sp.4_3_47FAA) |
PF00578(AhpC-TSA) | 4 | SER A 7ILE A 122LEU A 3PRO A 10 | None | 0.97A | 5u4sB-2lrnA:2.0 | 5u4sB-2lrnA:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2myg | DITHIOL GLUTAREDOXIN1 (Trypanosomabrucei) |
PF00462(Glutaredoxin) | 4 | ILE A 6LEU A 54MET A 48MET A 9 | None | 1.01A | 5u4sB-2mygA:undetectable | 5u4sB-2mygA:18.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nwq | PROBABLE SHORT-CHAINDEHYDROGENASE (Pseudomonasaeruginosa) |
PF00106(adh_short) | 4 | ASN A 85ILE A 211LEU A 137PRO A 213 | None | 1.00A | 5u4sB-2nwqA:25.2 | 5u4sB-2nwqA:26.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pzi | PROBABLESERINE/THREONINE-PROTEIN KINASE PKNG (Mycobacteriumtuberculosis) |
PF00069(Pkinase)PF16918(PknG_TPR)PF16919(PknG_rubred) | 4 | ILE A 260LEU A 261MET A 388LEU A 392 | None | 0.90A | 5u4sB-2pziA:undetectable | 5u4sB-2pziA:18.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rfa | TRANSIENT RECEPTORPOTENTIAL CATIONCHANNEL SUBFAMILY VMEMBER 6 (Mus musculus) |
PF12796(Ank_2)PF13637(Ank_4) | 4 | ILE A 189LEU A 219MET A 215LEU A 218 | None | 1.08A | 5u4sB-2rfaA:undetectable | 5u4sB-2rfaA:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uye | REGULATORY PROTEIN (Burkholderiacepacia) |
PF03466(LysR_substrate) | 4 | ILE A 235LEU A 236MET A 174LEU A 259 | None | 0.93A | 5u4sB-2uyeA:undetectable | 5u4sB-2uyeA:23.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v3c | SIGNAL RECOGNITION54 KDA PROTEIN (Methanocaldococcusjannaschii) |
PF00448(SRP54)PF02881(SRP54_N)PF02978(SRP_SPB) | 4 | ILE C 108LEU C 199MET C 203LEU C 200 | None | 0.98A | 5u4sB-2v3cC:2.3 | 5u4sB-2v3cC:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wzs | PUTATIVEALPHA-1,2-MANNOSIDASE (Bacteroidesthetaiotaomicron) |
PF07971(Glyco_hydro_92) | 4 | ILE A 402LEU A 403LEU A 423PRO A 383 | None | 1.02A | 5u4sB-2wzsA:undetectable | 5u4sB-2wzsA:15.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yrb | PROTEIN FANTOM (Homo sapiens) |
PF11618(C2-C2_1) | 4 | SER A 707ILE A 703LEU A 735LEU A 600 | None | 1.07A | 5u4sB-2yrbA:undetectable | 5u4sB-2yrbA:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3al0 | GLUTAMYL-TRNA(GLN)AMIDOTRANSFERASESUBUNIT A (Thermotogamaritima) |
PF01425(Amidase) | 4 | SER A 304ILE A 344LEU A 351PRO A 300 | None | 1.09A | 5u4sB-3al0A:undetectable | 5u4sB-3al0A:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bdz | P450CIN (Citrobacterbraakii) |
PF00067(p450) | 4 | ILE A 234LEU A 235LEU A 157MET A 90 | HEM A 450 (-4.7A)NoneNoneHEM A 450 (-4.6A) | 0.98A | 5u4sB-3bdzA:undetectable | 5u4sB-3bdzA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cg1 | UPF0100 PROTEINPF0080 (Pyrococcusfuriosus) |
PF13531(SBP_bac_11) | 4 | ILE A 144LEU A 145LEU A 185MET A 134 | None | 0.86A | 5u4sB-3cg1A:undetectable | 5u4sB-3cg1A:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cg3 | UPF0100 PROTEINPH0151 (Pyrococcushorikoshii) |
PF13531(SBP_bac_11) | 4 | ILE A 139LEU A 140LEU A 180MET A 129 | None | 0.80A | 5u4sB-3cg3A:undetectable | 5u4sB-3cg3A:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ckm | YRAM (HI1655) (Haemophilusinfluenzae) |
PF04348(LppC) | 4 | ILE A 276LEU A 320LEU A 321MET A 519 | None | 1.01A | 5u4sB-3ckmA:2.1 | 5u4sB-3ckmA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d6n | DIHYDROOROTASE (Aquifexaeolicus) |
PF01979(Amidohydro_1) | 4 | ILE A 219LEU A 220MET A 163LEU A 167 | None | 0.93A | 5u4sB-3d6nA:3.2 | 5u4sB-3d6nA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e9a | 2-DEHYDRO-3-DEOXYPHOSPHOOCTONATEALDOLASE (Vibrio cholerae) |
PF00793(DAHP_synth_1) | 4 | ILE A 233LEU A 229MET A 267LEU A 270 | None | 1.08A | 5u4sB-3e9aA:undetectable | 5u4sB-3e9aA:23.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g87 | MALONYL COA-ACYLCARRIER PROTEINTRANSACYLASE (Burkholderiapseudomallei) |
PF00698(Acyl_transf_1) | 4 | ILE A 44LEU A 47LEU A 56PRO A 64 | None | 0.91A | 5u4sB-3g87A:undetectable | 5u4sB-3g87A:24.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gpi | NAD-DEPENDENTEPIMERASE/DEHYDRATASE (Methylobacillusflagellatus) |
PF13460(NAD_binding_10) | 4 | ASN A 249ILE A 260LEU A 252PRO A 262 | None | 1.05A | 5u4sB-3gpiA:14.9 | 5u4sB-3gpiA:24.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i9v | NADH-QUINONEOXIDOREDUCTASESUBUNIT 15 (Thermusthermophilus) |
PF11497(NADH_Oxid_Nqo15) | 4 | ILE 7 82LEU 7 16MET 7 20LEU 7 17 | None | 0.99A | 5u4sB-3i9v7:undetectable | 5u4sB-3i9v7:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l2e | GLYCOCYAMINE KINASEALPHA CHAIN (Namalycastissp. ST01) |
PF00217(ATP-gua_Ptrans)PF02807(ATP-gua_PtransN) | 4 | ILE A 291LEU A 288LEU A 353PRO A 295 | None | 1.03A | 5u4sB-3l2eA:undetectable | 5u4sB-3l2eA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m03 | ORIGIN RECOGNITIONCOMPLEX SUBUNIT 6 (Homo sapiens) |
no annotation | 4 | ILE A 96LEU A 101LEU A 145PRO A 138 | NoneNoneNoneMES A 1 (-3.5A) | 1.02A | 5u4sB-3m03A:undetectable | 5u4sB-3m03A:16.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m6i | L-ARABINITOL4-DEHYDROGENASE (Neurosporacrassa) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | ILE A 355LEU A 193MET A 196LEU A 197 | None | 0.92A | 5u4sB-3m6iA:9.2 | 5u4sB-3m6iA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3na0 | CHOLESTEROLSIDE-CHAIN CLEAVAGEENZYME,MITOCHONDRIAL (Homo sapiens) |
PF00067(p450) | 4 | SER A 380ILE A 381LEU A 377LEU A 352 | None | 0.95A | 5u4sB-3na0A:undetectable | 5u4sB-3na0A:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nz4 | PHENYLALANINEAMMONIA-LYASE (Taxuscanadensis) |
PF00221(Lyase_aromatic) | 4 | ILE A 185LEU A 188LEU A 211MET A 133 | None | 1.00A | 5u4sB-3nz4A:undetectable | 5u4sB-3nz4A:18.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ohm | 1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATEPHOSPHODIESTERASEBETA-3 (Homo sapiens) |
PF00168(C2)PF00387(PI-PLC-Y)PF00388(PI-PLC-X)PF09279(EF-hand_like) | 4 | ILE B 250LEU B 246MET B 291LEU B 241 | None | 0.74A | 5u4sB-3ohmB:undetectable | 5u4sB-3ohmB:14.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3okz | PUTATIVEUNCHARACTERIZEDPROTEIN GBS0355 (Streptococcusagalactiae) |
PF03816(LytR_cpsA_psr) | 4 | SER A 209LEU A 206MET A 157LEU A 160 | None | 0.98A | 5u4sB-3okzA:undetectable | 5u4sB-3okzA:23.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pt3 | E3 UBIQUITIN-PROTEINLIGASE UBR5 (Homo sapiens) |
PF00632(HECT) | 4 | ASN A2703SER A2700ILE A2754LEU A2776 | None | 0.99A | 5u4sB-3pt3A:undetectable | 5u4sB-3pt3A:17.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pua | PHD FINGER PROTEIN 2 (Homo sapiens) |
PF02373(JmjC) | 4 | ILE A 401LEU A 402MET A 373LEU A 377 | None | 0.95A | 5u4sB-3puaA:undetectable | 5u4sB-3puaA:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qbw | ANHYDRO-N-ACETYLMURAMIC ACID KINASE (Pseudomonasaeruginosa) |
PF03702(AnmK) | 4 | SER A 93ILE A 91LEU A 7MET A 16 | None | 0.98A | 5u4sB-3qbwA:undetectable | 5u4sB-3qbwA:23.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t0q | AGR253WP (Eremotheciumgossypii) |
PF00225(Kinesin) | 4 | SER A 441ILE A 588LEU A 442MET A 494 | None | 0.94A | 5u4sB-3t0qA:undetectable | 5u4sB-3t0qA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t8q | MANDELATERACEMASE/MUCONATELACTONIZING ENZYMEFAMILY PROTEIN (Hoefleaphototrophica) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | ILE A 259LEU A 299LEU A 300PRO A 257 | None | 0.90A | 5u4sB-3t8qA:2.3 | 5u4sB-3t8qA:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tcs | RACEMASE, PUTATIVE (Roseobacterdenitrificans) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | ILE A 259LEU A 299LEU A 300PRO A 257 | None | 0.91A | 5u4sB-3tcsA:undetectable | 5u4sB-3tcsA:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u4f | MANDELATERACEMASE/MUCONATELACTONIZING ENZYMEFAMILY PROTEIN (Roseovariusnubinhibens) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | ILE A 259LEU A 299LEU A 300PRO A 257 | None | 0.90A | 5u4sB-3u4fA:undetectable | 5u4sB-3u4fA:23.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uet | ALPHA-1,3/4-FUCOSIDASE (Bifidobacteriumlongum) |
PF01120(Alpha_L_fucos) | 4 | ILE A 286LEU A 322MET A 31LEU A 320 | None | 1.04A | 5u4sB-3uetA:undetectable | 5u4sB-3uetA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v7n | THREONINE SYNTHASE (Burkholderiathailandensis) |
PF00291(PALP)PF14821(Thr_synth_N) | 4 | ASN A 259ILE A 288LEU A 286LEU A 45 | None | 0.89A | 5u4sB-3v7nA:2.1 | 5u4sB-3v7nA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vpo | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASESUBUNIT M2 (Homo sapiens) |
PF00268(Ribonuc_red_sm) | 4 | ILE A 313LEU A 246MET A 252LEU A 255 | None | 0.92A | 5u4sB-3vpoA:undetectable | 5u4sB-3vpoA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vqi | ATG5 (Kluyveromycesmarxianus) |
PF04106(APG5) | 4 | SER A 228ILE A 229LEU A 225LEU A 220 | None | 0.82A | 5u4sB-3vqiA:undetectable | 5u4sB-3vqiA:24.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wiq | KOJIBIOSEPHOSPHORYLASE (Caldicellulosiruptorsaccharolyticus) |
PF03632(Glyco_hydro_65m)PF03633(Glyco_hydro_65C)PF03636(Glyco_hydro_65N) | 4 | SER A 450ILE A 453LEU A 508LEU A 512 | None | 0.99A | 5u4sB-3wiqA:undetectable | 5u4sB-3wiqA:16.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wst | PROTEIN ARGININEN-METHYLTRANSFERASE7 (Caenorhabditiselegans) |
PF13649(Methyltransf_25) | 4 | ILE A 37LEU A 77MET A 81LEU A 78 | NoneNoneNoneSAH A 701 (-3.9A) | 0.79A | 5u4sB-3wstA:5.1 | 5u4sB-3wstA:17.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b8a | GENERAL NEGATIVEREGULATOR OFTRANSCRIPTIONSUBUNIT 1POLY(A) RIBONUCLEASEPOP2 (Saccharomycescerevisiae;Saccharomycescerevisiae) |
PF16415(CNOT1_CAF1_bind)PF04857(CAF1) | 4 | ASN A 952ILE B 171LEU B 174MET B 146 | None | 1.07A | 5u4sB-4b8aA:undetectable | 5u4sB-4b8aA:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dcm | RIBOSOMAL RNA LARGESUBUNITMETHYLTRANSFERASE G (Escherichiacoli) |
PF05175(MTS) | 4 | ASN A 206SER A 99ILE A 70LEU A 120 | None | 0.97A | 5u4sB-4dcmA:6.0 | 5u4sB-4dcmA:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dwq | TRNA-SPLICING LIGASERTCB (Pyrococcushorikoshii) |
PF01139(RtcB) | 4 | SER A 270ILE A 256LEU A 53PRO A 272 | None | 1.08A | 5u4sB-4dwqA:undetectable | 5u4sB-4dwqA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e1j | GLYCEROL KINASE (Sinorhizobiummeliloti) |
PF00370(FGGY_N)PF02782(FGGY_C) | 4 | ILE A 327LEU A 412MET A 416LEU A 413 | None | 1.04A | 5u4sB-4e1jA:undetectable | 5u4sB-4e1jA:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gnk | 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATEPHOSPHODIESTERASEBETA-3 (Homo sapiens) |
PF00168(C2)PF00387(PI-PLC-Y)PF00388(PI-PLC-X)PF09279(EF-hand_like) | 4 | ILE B 250LEU B 246MET B 291LEU B 241 | None | 0.83A | 5u4sB-4gnkB:undetectable | 5u4sB-4gnkB:12.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h40 | PUTATIVE CELLADHESION PROTEIN (Bacteroidesfragilis) |
PF15415(Mfa_like_2) | 4 | ILE A 37LEU A 193LEU A 195MET A 131 | None | 0.75A | 5u4sB-4h40A:undetectable | 5u4sB-4h40A:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iuw | NEUTRALENDOPEPTIDASE (Lactobacillusrhamnosus) |
PF01431(Peptidase_M13)PF05649(Peptidase_M13_N) | 4 | ILE A 117LEU A 251LEU A 214PRO A 229 | None | 1.06A | 5u4sB-4iuwA:undetectable | 5u4sB-4iuwA:16.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jgl | HYPOTHETICAL PROTEIN (Bacteroideseggerthii) |
no annotation | 4 | ILE A 89LEU A 78MET A 71LEU A 76 | None | 0.99A | 5u4sB-4jglA:undetectable | 5u4sB-4jglA:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k3z | D-ERYTHRULOSE4-PHOSPHATEDEHYDROGENASE (Brucellamelitensis) |
no annotation | 4 | ILE A 105LEU A 108MET A 58LEU A 62 | None | 0.91A | 5u4sB-4k3zA:undetectable | 5u4sB-4k3zA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kf6 | GLYCOLIPID TRANSFERPROTEINDOMAIN-CONTAININGPROTEIN 1 (Homo sapiens) |
PF08718(GLTP) | 4 | ILE A 33LEU A 29MET A 82LEU A 79 | None | 0.66A | 5u4sB-4kf6A:undetectable | 5u4sB-4kf6A:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mm0 | P450-LIKEMONOOXYGENASE (Streptomycesgriseoviridis) |
PF00067(p450) | 4 | ILE A 229LEU A 230LEU A 150MET A 83 | NoneNoneNoneHEM A 401 (-4.2A) | 0.89A | 5u4sB-4mm0A:undetectable | 5u4sB-4mm0A:23.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mmq | FUSION GLYCOPROTEINF1 FUSED WITHFIBRITINTRIMERIZATION DOMAIN (Escherichiavirus T4;Humanorthopneumovirus) |
PF00523(Fusion_gly) | 4 | ILE B 261LEU B 257LEU B 252PRO B 304 | None | 0.81A | 5u4sB-4mmqB:undetectable | 5u4sB-4mmqB:19.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mwa | 4-HYDROXY-3-METHYLBUT-2-EN-1-YLDIPHOSPHATE SYNTHASE (Bacillusanthracis) |
PF04551(GcpE) | 4 | SER D 218ILE D 205LEU D 222LEU D 252 | None | 0.96A | 5u4sB-4mwaD:2.1 | 5u4sB-4mwaD:23.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nov | XYLOSIDASE/ARABINOFURANOSIDASE XSA43E (Butyrivibrioproteoclasticus) |
PF04616(Glyco_hydro_43) | 4 | ASN A 257ILE A 261MET A 248LEU A 229 | None | 1.08A | 5u4sB-4novA:undetectable | 5u4sB-4novA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ovr | TRAP DICARBOXYLATETRANSPORTER, DCTPSUBUNIT (Xanthobacterautotrophicus) |
PF03480(DctP) | 4 | ILE A 156LEU A 162MET A 179LEU A 182 | None | 0.99A | 5u4sB-4ovrA:undetectable | 5u4sB-4ovrA:23.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qpj | CELL CYCLE RESPONSEREGULATOR CTRA (Brucellaabortus) |
PF00072(Response_reg) | 4 | ILE C 47LEU C 76MET C 99LEU C 78 | None | 0.82A | 5u4sB-4qpjC:7.4 | 5u4sB-4qpjC:24.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rgl | FILAMENTATIONINDUCED BY CAMPPROTEIN FIC (Desulfovibrioalaskensis) |
PF02661(Fic) | 4 | SER A 171ILE A 199LEU A 247PRO A 167 | None | 1.05A | 5u4sB-4rglA:undetectable | 5u4sB-4rglA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4umz | CYTOCHROME P450HYDROXYLASE PIKC (Streptomycesvenezuelae) |
PF00067(p450) | 4 | ILE A 239LEU A 240LEU A 161MET A 92 | HEM A1407 ( 4.9A)NoneNoneHEM A1407 (-3.8A) | 1.08A | 5u4sB-4umzA:undetectable | 5u4sB-4umzA:23.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wbo | RHODOPSIN KINASE (Bos taurus) |
PF00069(Pkinase)PF00615(RGS) | 4 | ILE A 238LEU A 239MET A 264LEU A 262 | NoneNoneANW A 601 (-3.2A)None | 0.92A | 5u4sB-4wboA:undetectable | 5u4sB-4wboA:17.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xa9 | GALA PROTEIN TYPE 1,3 OR 4 (Legionellapneumophila) |
PF13516(LRR_6) | 4 | ASN A 243ILE A 228LEU A 229LEU A 240 | None | 0.97A | 5u4sB-4xa9A:undetectable | 5u4sB-4xa9A:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xvm | DNA POLYMERASE NU (Homo sapiens) |
PF00476(DNA_pol_A) | 4 | ILE A 356LEU A 420LEU A 423PRO A 358 | None | 0.94A | 5u4sB-4xvmA:undetectable | 5u4sB-4xvmA:17.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ye5 | PEPTIDOGLYCANSYNTHETASEPENICILLIN-BINDINGPROTEIN 3 (Bifidobacteriumadolescentis) |
PF00905(Transpeptidase)PF03717(PBP_dimer) | 4 | ILE A 87LEU A 153LEU A 129PRO A 90 | None | 0.98A | 5u4sB-4ye5A:undetectable | 5u4sB-4ye5A:17.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ci7 | SERINE/THREONINE-PROTEIN KINASE ULK1 (Homo sapiens) |
PF00069(Pkinase) | 4 | ILE A 66LEU A 67MET A 92LEU A 90 | NoneNone51W A 401 (-3.9A)None | 1.05A | 5u4sB-5ci7A:undetectable | 5u4sB-5ci7A:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dz6 | POLYKETIDEBIOSYNTHESIS MALONYLCOA-ACYL CARRIERPROTEIN TRANSACYLASEPKSC (Bacillussubtilis) |
PF00698(Acyl_transf_1) | 4 | ILE A 39LEU A 42LEU A 51PRO A 59 | None | 0.86A | 5u4sB-5dz6A:undetectable | 5u4sB-5dz6A:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eqt | PROTEASOME-ACTIVATING NUCLEOTIDASE (Pyrococcushorikoshii) |
PF00004(AAA) | 4 | ILE A 211LEU A 233MET A 237LEU A 234 | None | 1.07A | 5u4sB-5eqtA:undetectable | 5u4sB-5eqtA:23.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h42 | UNCHARACTERIZEDPROTEIN (Lachnoclostridiumphytofermentans) |
PF17167(Glyco_hydro_36) | 4 | ILE A 478LEU A 489MET A 508LEU A 487 | None | 1.02A | 5u4sB-5h42A:undetectable | 5u4sB-5h42A:12.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ig5 | CAMKII-B HUB (Nematostellavectensis) |
PF08332(CaMKII_AD) | 4 | SER A 360ILE A 361LEU A 357LEU A 372 | None | 1.02A | 5u4sB-5ig5A:undetectable | 5u4sB-5ig5A:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l22 | ABC TRANSPORTER(HLYB SUBFAMILY) (Aquifexaeolicus) |
no annotation | 4 | ILE B 137LEU B 134MET B 84LEU B 129 | None | 1.08A | 5u4sB-5l22B:undetectable | 5u4sB-5l22B:18.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lb7 | KATANIN P80 WD40REPEAT-CONTAININGSUBUNIT B1 (Mus musculus) |
PF13925(Katanin_con80) | 4 | ILE A 588LEU A 589MET A 654LEU A 653 | None | 0.91A | 5u4sB-5lb7A:undetectable | 5u4sB-5lb7A:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mzn | HELICASESEN1,HELICASE SEN1 (Saccharomycescerevisiae) |
PF13086(AAA_11)PF13087(AAA_12) | 4 | SER A1600ILE A1601LEU A1638MET A1642 | None | 0.82A | 5u4sB-5mznA:2.1 | 5u4sB-5mznA:15.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oat | SERINE/THREONINE-PROTEIN KINASE PINK1,MITOCHONDRIAL-LIKEPROTEIN (Triboliumcastaneum) |
no annotation | 4 | ILE A 253LEU A 292MET A 198LEU A 290 | None | 0.94A | 5u4sB-5oatA:undetectable | 5u4sB-5oatA:19.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ojs | TRANSCRIPTION-ASSOCIATED PROTEIN 1 (Saccharomycescerevisiae) |
PF00454(PI3_PI4_kinase)PF02259(FAT) | 4 | SER T2636ILE T2639LEU T2640LEU T2665 | None | 0.97A | 5u4sB-5ojsT:undetectable | 5u4sB-5ojsT:4.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5u4s | PUTATIVE SHORT CHAINDEHYDROGENASE (Burkholderiacenocepacia) |
PF00106(adh_short) | 8 | ASN A 83SER A 131ILE A 132LEU A 133MET A 141LEU A 144PRO A 176MET A 215 | BEZ A 301 (-4.0A)BEZ A 301 (-2.6A)NoneBEZ A 301 (-4.2A)BEZ A 301 (-3.5A)BEZ A 301 (-4.9A)BEZ A 301 ( 4.0A)BEZ A 301 ( 4.1A) | 0.14A | 5u4sB-5u4sA:41.8 | 5u4sB-5u4sA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u70 | POTASSIUM CHANNELSUBFAMILY T MEMBER 1 (Gallus gallus) |
PF03493(BK_channel_a)PF07885(Ion_trans_2) | 4 | ILE A1148LEU A 511MET A 932LEU A 929 | None | 0.99A | 5u4sB-5u70A:4.5 | 5u4sB-5u70A:11.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w81 | CYSTIC FIBROSISTRANSMEMBRANECONDUCTANCEREGULATOR (Danio rerio) |
PF00005(ABC_tran)PF00664(ABC_membrane)PF14396(CFTR_R) | 4 | ILE A 372LEU A 70MET A 74LEU A 71 | None | 1.06A | 5u4sB-5w81A:undetectable | 5u4sB-5w81A:10.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wo6 | TRANSIENT RECEPTORPOTENTIAL CATIONCHANNEL SUBFAMILY VMEMBER 6 (Rattusnorvegicus) |
PF00520(Ion_trans)PF12796(Ank_2)PF13637(Ank_4) | 4 | ILE A 189LEU A 219MET A 215LEU A 218 | ILE A 189 ( 0.7A)LEU A 219 ( 0.6A)MET A 215 ( 0.0A)LEU A 218 ( 0.6A) | 1.02A | 5u4sB-5wo6A:undetectable | 5u4sB-5wo6A:15.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x6o | SERINE/THREONINE-PROTEIN KINASE MEC1 (Saccharomycescerevisiae) |
no annotation | 4 | ASN C1700ILE C1666LEU C1696PRO C1662 | None | 1.06A | 5u4sB-5x6oC:undetectable | 5u4sB-5x6oC:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y05 | MSMEG_4306 (Mycolicibacteriumsmegmatis) |
no annotation | 4 | ILE A 72LEU A 117MET A 121LEU A 118 | None | 0.85A | 5u4sB-5y05A:undetectable | 5u4sB-5y05A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y6q | ALDEHYDE OXIDASESMALL SUBUNITALDEHYDE OXIDASEMEDIUM SUBUNIT (Methylobacillussp. KY4400;Methylobacillussp. KY4400) |
no annotationno annotation | 4 | ASN A 136SER B 99ILE B 102MET B 105 | NoneNoneFAD B 401 (-4.6A)None | 1.03A | 5u4sB-5y6qA:undetectable | 5u4sB-5y6qA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6apg | DISD PROTEIN (Sorangiumcellulosum) |
no annotation | 4 | ILE A 39LEU A 42LEU A 51PRO A 59 | None | 0.84A | 5u4sB-6apgA:undetectable | 5u4sB-6apgA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d7t | TRANSIENT RECEPTORPOTENTIAL CATIONCHANNEL SUBFAMILY VMEMBER 6 (Homo sapiens) |
no annotation | 4 | ILE A 189LEU A 219MET A 215LEU A 218 | None | 1.04A | 5u4sB-6d7tA:undetectable | 5u4sB-6d7tA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ez8 | HUNTINGTINFACTOR VIII INTRON22 PROTEIN (Homo sapiens;Homo sapiens) |
no annotationno annotation | 4 | SER B 324LEU B 321LEU B 320PRO A1996 | None | 0.79A | 5u4sB-6ez8B:undetectable | 5u4sB-6ez8B:undetectable |