SIMILAR PATTERNS OF AMINO ACIDS FOR 5U4S_A_BEZA301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0f GLUTATHIONE
S-TRANSFERASE

(Escherichia
coli) 		PF00043
(GST_C)
PF13409
(GST_N_2) 		4 ILE A  69
LEU A  55
MET A   1
LEU A  57
 None
 0.90A 5u4sA-1a0fA:
undetectable		 5u4sA-1a0fA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad6 RETINOBLASTOMA TUMOR
SUPPRESSOR

(Homo sapiens) 		PF01858
(RB_A) 		4 ILE A 401
LEU A 400
MET A 457
LEU A 461
 None
 1.00A 5u4sA-1ad6A:
undetectable		 5u4sA-1ad6A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cfr RESTRICTION
ENDONUCLEASE

(Citrobacter
freundii) 		PF07832
(Bse634I) 		4 ILE A 140
LEU A 147
MET A 150
LEU A 151
 None
 0.93A 5u4sA-1cfrA:
3.0		 5u4sA-1cfrA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj2 PROTEIN
(P-HYDROXYBENZOATE
HYDROXYLASE)

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		4 SER A 168
ILE A 164
LEU A 129
LEU A 132
 None
FAD  A 395 (-4.0A)
None
None
 0.95A 5u4sA-1cj2A:
undetectable		 5u4sA-1cj2A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gh6 RETINOBLASTOMA-ASSOC
IATED PROTEIN

(Homo sapiens) 		PF01857
(RB_B)
PF01858
(RB_A) 		5 ILE B 401
LEU B 400
MET B 457
LEU B 461
PRO B 411
 None
 1.40A 5u4sA-1gh6B:
undetectable		 5u4sA-1gh6B:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7o 4-HYDROXYPHENYLACETA
TE DEGRADATION
BIFUNCTIONAL
ISOMERASE/DECARBOXYL
ASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		4 ASN A  43
ILE A 283
LEU A 385
MET A 383
 None
 0.99A 5u4sA-1i7oA:
undetectable		 5u4sA-1i7oA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jeq KU70

(Homo sapiens) 		PF02037
(SAP)
PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N) 		4 SER A 257
ILE A 273
LEU A 256
PRO A 402
 None
 0.89A 5u4sA-1jeqA:
2.8		 5u4sA-1jeqA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum) 		PF03063
(Prismane) 		4 ILE A 442
LEU A 475
MET A 526
LEU A 477
 None
 1.02A 5u4sA-1jqkA:
4.1		 5u4sA-1jqkA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k86 CASPASE-7

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 ASN A  75
ILE A 183
LEU A 141
MET A 119
 None
 1.03A 5u4sA-1k86A:
5.7		 5u4sA-1k86A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ln4 HYPOTHETICAL PROTEIN
YHBY

(Escherichia
coli) 		PF01985
(CRS1_YhbY) 		4 ILE A  93
LEU A  95
LEU A  97
PRO A  87
 None
 1.01A 5u4sA-1ln4A:
undetectable		 5u4sA-1ln4A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxy ARGININE DEIMINASE

(Mycoplasma
arginini) 		PF02274
(Amidinotransf) 		4 SER A 321
ILE A 322
LEU A 318
LEU A 313
 None
 0.75A 5u4sA-1lxyA:
undetectable		 5u4sA-1lxyA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mec MENGO VIRUS COAT
PROTEIN (SUBUNIT
VP1)

(Cardiovirus A) 		no annotation 4 SER 1 192
LEU 1 194
LEU 1 197
PRO 1 218
 None
 1.01A 5u4sA-1mec1:
undetectable		 5u4sA-1mec1:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pp0 VOLVATOXIN A2

(Volvariella
volvacea) 		PF01338
(Bac_thur_toxin) 		4 SER A  21
ILE A  22
LEU A  13
PRO A   9
 None
 1.02A 5u4sA-1pp0A:
undetectable		 5u4sA-1pp0A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1psw ADP-HEPTOSE LPS
HEPTOSYLTRANSFERASE
II

(Escherichia
coli) 		PF01075
(Glyco_transf_9) 		4 ASN A  89
SER A  93
ILE A   6
PRO A   8
 None
 0.99A 5u4sA-1pswA:
5.8		 5u4sA-1pswA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
IRON-SULFUR PROTEIN

(Wolinella
succinogenes) 		PF13085
(Fer2_3)
PF13183
(Fer4_8) 		4 ILE B   7
LEU B  91
MET B  67
LEU B 103
 None
 1.01A 5u4sA-1qlbB:
undetectable		 5u4sA-1qlbB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sny SNIFFER CG10964-PA

(Drosophila
melanogaster) 		PF00106
(adh_short) 		4 SER A 154
ILE A 155
LEU A 156
MET A 167
 NAP  A 400 (-3.7A)
None
None
None
 0.89A 5u4sA-1snyA:
24.9		 5u4sA-1snyA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tnd TRANSDUCIN

(Bos taurus) 		PF00503
(G-alpha) 		4 ILE A 220
LEU A  34
MET A 194
LEU A  32
 None
 0.92A 5u4sA-1tndA:
2.5		 5u4sA-1tndA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE

(Thermus
thermophilus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 ASN A  80
ILE A  76
LEU A 106
LEU A 107
 CSO  A 110 ( 4.5A)
None
None
None
 0.89A 5u4sA-1ub7A:
undetectable		 5u4sA-1ub7A:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE

(Pyrococcus
furiosus) 		no annotation 4 ILE B 798
LEU B 836
LEU B 859
PRO B 824
 None
 0.91A 5u4sA-1us8B:
undetectable		 5u4sA-1us8B:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb3 THREONINE SYNTHASE

(Escherichia
coli) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 SER A 261
LEU A 258
LEU A 315
PRO A  36
 None
 1.01A 5u4sA-1vb3A:
undetectable		 5u4sA-1vb3A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wgw 'SIGNAL RECOGNITION
PARTICLE 54

(Mus musculus) 		PF02881
(SRP54_N) 		4 ILE A  64
LEU A  32
MET A  35
LEU A  36
 None
 0.93A 5u4sA-1wgwA:
undetectable		 5u4sA-1wgwA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wnb PUTATIVE BETAINE
ALDEHYDE
DEHYDROGENASE

(Escherichia
coli) 		PF00171
(Aldedh) 		4 ILE A 226
LEU A 247
MET A 245
LEU A 222
 None
 1.01A 5u4sA-1wnbA:
3.7		 5u4sA-1wnbA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdp POLYPHOSPHATE KINASE

(Escherichia
coli) 		PF02503
(PP_kinase)
PF13089
(PP_kinase_N)
PF13090
(PP_kinase_C) 		4 LEU A 513
MET A 517
LEU A 514
PRO A 627
 None
 0.93A 5u4sA-1xdpA:
undetectable		 5u4sA-1xdpA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N

(Mus musculus) 		PF00079
(Serpin) 		4 ILE A 407
LEU A 120
LEU A 121
PRO A 409
 None
 0.99A 5u4sA-1yxaA:
undetectable		 5u4sA-1yxaA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2a RAS-RELATED PROTEIN
RAB-23

(Mus musculus) 		PF00071
(Ras) 		4 ILE A  51
LEU A  60
MET A  12
LEU A  62
 None
 1.00A 5u4sA-1z2aA:
5.6		 5u4sA-1z2aA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpg GLUCOSE 6-PHOSPHATE
DEHYDROGENASE

(Leuconostoc
mesenteroides) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		4 ASN A 142
ILE A 126
LEU A 130
LEU A 136
 None
 0.96A 5u4sA-2dpgA:
6.0		 5u4sA-2dpgA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewc CONSERVED
HYPOTHETICAL PROTEIN

(Streptococcus
pyogenes) 		no annotation 4 LEU A  60
MET A  49
LEU A  53
PRO A  92
 None
 0.92A 5u4sA-2ewcA:
undetectable		 5u4sA-2ewcA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus sp.
GL1) 		PF07470
(Glyco_hydro_88) 		4 ASN A 233
SER A 180
ILE A 146
LEU A 151
 None
 0.97A 5u4sA-2fv0A:
undetectable		 5u4sA-2fv0A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0a TRANSCRIPTIONAL
REGULATOR

(Thermus
thermophilus) 		PF13377
(Peripla_BP_3) 		4 ILE A 124
LEU A 308
MET A 312
LEU A 309
 None
 0.96A 5u4sA-2h0aA:
2.8		 5u4sA-2h0aA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hb6 LEUCINE
AMINOPEPTIDASE 1

(Caenorhabditis
elegans) 		PF00883
(Peptidase_M17) 		4 ILE A 441
LEU A 440
MET A 421
LEU A 414
 None
 1.03A 5u4sA-2hb6A:
2.1		 5u4sA-2hb6A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjm GLYCOSYL
TRANSFERASE, GROUP 1
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		4 ILE A 306
LEU A 288
MET A 292
LEU A 289
 None
 0.99A 5u4sA-2jjmA:
8.9		 5u4sA-2jjmA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l9j MATRIX PROTEIN 2-1

(Human
orthopneumovirus) 		PF06436
(Pneumovirus_M2) 		4 ILE A 135
LEU A 103
MET A  99
LEU A 102
 None
 0.96A 5u4sA-2l9jA:
undetectable		 5u4sA-2l9jA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lrn THIOL:DISULFIDE
INTERCHANGE PROTEIN

(Bacteroides sp.
4_3_47FAA) 		PF00578
(AhpC-TSA) 		4 SER A   7
ILE A 122
LEU A   3
PRO A  10
 None
 0.98A 5u4sA-2lrnA:
undetectable		 5u4sA-2lrnA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmt GLUTATHIONE
TRANSFERASE

(Proteus
mirabilis) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 ILE A  69
LEU A  55
MET A   1
LEU A  57
 None
 0.90A 5u4sA-2pmtA:
undetectable		 5u4sA-2pmtA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16918
(PknG_TPR)
PF16919
(PknG_rubred) 		4 ILE A 260
LEU A 261
MET A 388
LEU A 392
 None
 0.92A 5u4sA-2pziA:
undetectable		 5u4sA-2pziA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)

(Homo sapiens) 		PF00215
(OMPdecase) 		4 SER A 276
ILE A 277
LEU A 273
LEU A 460
 None
 1.02A 5u4sA-2qcmA:
2.4		 5u4sA-2qcmA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfm PUTATIVE ANKYRIN
REPEAT PROTEIN
TV1425

(Thermoplasma
volcanium) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		4 SER A 105
ILE A 106
LEU A 102
LEU A 117
 None
 0.88A 5u4sA-2rfmA:
undetectable		 5u4sA-2rfmA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uye REGULATORY PROTEIN

(Burkholderia
cepacia) 		PF03466
(LysR_substrate) 		4 ILE A 235
LEU A 236
MET A 174
LEU A 259
 None
 0.96A 5u4sA-2uyeA:
undetectable		 5u4sA-2uyeA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v3c SIGNAL RECOGNITION
54 KDA PROTEIN

(Methanocaldococcus
jannaschii) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		4 ILE C 108
LEU C 199
MET C 203
LEU C 200
 None
 1.01A 5u4sA-2v3cC:
4.8		 5u4sA-2v3cC:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9k UNCHARACTERIZED
PROTEIN FLJ32312

(Homo sapiens) 		no annotation 4 ILE A 418
LEU A 476
MET A 464
LEU A 478
 None
 0.84A 5u4sA-2v9kA:
undetectable		 5u4sA-2v9kA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd3 ATP
PHOSPHORIBOSYLTRANSF
ERASE

(Methanothermobacter
thermautotrophicus) 		PF01634
(HisG)
PF08029
(HisG_C) 		4 ILE A 266
LEU A 265
MET A 233
LEU A 232
 None
 0.97A 5u4sA-2vd3A:
undetectable		 5u4sA-2vd3A:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk2 CHITINASE A

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 ILE A 312
LEU A 342
MET A 345
LEU A 346
 None
 0.99A 5u4sA-2wk2A:
2.5		 5u4sA-2wk2A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF13519
(VWA_2) 		4 ASN A 626
SER A 629
LEU A 646
PRO A 640
 None
 1.03A 5u4sA-2ww8A:
2.3		 5u4sA-2ww8A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		4 ILE A 402
LEU A 403
LEU A 423
PRO A 383
 None
 1.01A 5u4sA-2wzsA:
undetectable		 5u4sA-2wzsA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x9q CYCLODIPEPTIDE
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF16715
(CDPS) 		4 ILE A 230
LEU A 259
MET A 262
LEU A 263
 None
 0.80A 5u4sA-2x9qA:
2.9		 5u4sA-2x9qA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7r LYSR-TYPE REGULATORY
PROTEIN

(Burkholderia
sp. DNT) 		PF03466
(LysR_substrate) 		4 ILE A 235
LEU A 236
MET A 174
LEU A 259
 None
 0.93A 5u4sA-2y7rA:
undetectable		 5u4sA-2y7rA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3t CYTOCHROME P450

(Streptomyces
sp. TP-A0274) 		PF00067
(p450) 		5 SER A 162
ILE A 161
LEU A 252
LEU A 175
PRO A 157
 None
 1.32A 5u4sA-2z3tA:
undetectable		 5u4sA-2z3tA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1j CELL CYCLE
CHECKPOINT PROTEIN
RAD1

(Homo sapiens) 		PF02144
(Rad1) 		4 ILE C  84
LEU C 119
MET C 110
LEU C 121
 None
 1.01A 5u4sA-3a1jC:
undetectable		 5u4sA-3a1jC:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9e CHITINASE A

(Vibrio harveyi) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 ILE A 312
LEU A 343
MET A 346
LEU A 347
 None
 1.00A 5u4sA-3b9eA:
3.5		 5u4sA-3b9eA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh2 ACETOACETATE
DECARBOXYLASE

(Clostridium
acetobutylicum) 		PF06314
(ADC) 		4 ILE A  53
LEU A  43
LEU A 216
PRO A  82
 None
 1.02A 5u4sA-3bh2A:
undetectable		 5u4sA-3bh2A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA

(Chlorobaculum
tepidum) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		4 ILE A 598
LEU A 615
LEU A 579
PRO A 595
 None
 0.99A 5u4sA-3cp8A:
4.4		 5u4sA-3cp8A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6n DIHYDROOROTASE

(Aquifex
aeolicus) 		PF01979
(Amidohydro_1) 		4 ILE A 219
LEU A 220
MET A 163
LEU A 167
 None
 0.97A 5u4sA-3d6nA:
2.4		 5u4sA-3d6nA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE

(Leishmania
major) 		PF00069
(Pkinase) 		4 SER A 136
ILE A 137
LEU A 133
LEU A 166
 None
 0.93A 5u4sA-3e3pA:
undetectable		 5u4sA-3e3pA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoe PYRUVATE KINASE

(Toxoplasma
gondii) 		PF00224
(PK)
PF02887
(PK_C) 		4 ILE A 412
LEU A 436
MET A 457
LEU A 438
 None
 0.80A 5u4sA-3eoeA:
undetectable		 5u4sA-3eoeA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezo MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Burkholderia
pseudomallei) 		PF00698
(Acyl_transf_1) 		4 ILE A  41
LEU A  44
LEU A  53
PRO A  61
 None
 0.98A 5u4sA-3ezoA:
undetectable		 5u4sA-3ezoA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g87 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Burkholderia
pseudomallei) 		PF00698
(Acyl_transf_1) 		4 ILE A  44
LEU A  47
LEU A  56
PRO A  64
 None
 0.95A 5u4sA-3g87A:
undetectable		 5u4sA-3g87A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4m PROTEASOME-ACTIVATIN
G NUCLEOTIDASE

(Methanocaldococcus
jannaschii) 		PF00004
(AAA) 		4 ILE A 275
LEU A 297
MET A 301
LEU A 298
 None
 1.00A 5u4sA-3h4mA:
undetectable		 5u4sA-3h4mA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7t GROUP 3 ALLERGEN
SMIPP-S YVT004A06

(Sarcoptes
scabiei) 		PF00089
(Trypsin) 		4 SER A  29
ILE A  30
LEU A 196
PRO A  13
 None
 0.89A 5u4sA-3h7tA:
undetectable		 5u4sA-3h7tA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs3 RIBOSE OPERON
REPRESSOR

(Lactobacillus
acidophilus) 		PF13377
(Peripla_BP_3) 		4 ILE A 121
LEU A 293
MET A 297
LEU A 294
 None
 0.93A 5u4sA-3hs3A:
2.3		 5u4sA-3hs3A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 15

(Thermus
thermophilus) 		PF11497
(NADH_Oxid_Nqo15) 		4 ILE 7  82
LEU 7  16
MET 7  20
LEU 7  17
 None
 0.97A 5u4sA-3i9v7:
undetectable		 5u4sA-3i9v7:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibh SACCHAROMYCES
CEREVISIAE GTT2

(Saccharomyces
cerevisiae) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 ILE A  89
LEU A  75
MET A  19
LEU A  77
 None
 0.99A 5u4sA-3ibhA:
undetectable		 5u4sA-3ibhA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iqt SIGNAL TRANSDUCTION
HISTIDINE-PROTEIN
KINASE BARA

(Escherichia
coli) 		PF01627
(Hpt) 		4 ILE A 882
LEU A 902
MET A 906
LEU A 903
 None
 1.01A 5u4sA-3iqtA:
undetectable		 5u4sA-3iqtA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ix1 N-FORMYL-4-AMINO-5-A
MINOMETHYL-2-METHYLP
YRIMIDINE BINDING
PROTEIN

(Bacillus
halodurans) 		PF09084
(NMT1) 		4 ASN A  42
SER A 279
ILE A 282
LEU A 283
 NFM  A 401 ( 4.0A)
None
None
None
 0.90A 5u4sA-3ix1A:
undetectable		 5u4sA-3ix1A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3klj NAD(FAD)-DEPENDENT
DEHYDROGENASE,
NIRB-FAMILY
(N-TERMINAL DOMAIN)

(Clostridium
acetobutylicum) 		PF07992
(Pyr_redox_2) 		4 SER A 167
ILE A 168
MET A 208
LEU A 211
 None
 0.98A 5u4sA-3kljA:
4.6		 5u4sA-3kljA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg7 4E10_S0_1EZ3A_002_C
(T246)

(synthetic
construct) 		PF00804
(Syntaxin) 		4 ILE A  36
LEU A  50
MET A  54
LEU A  51
 None
 0.91A 5u4sA-3lg7A:
undetectable		 5u4sA-3lg7A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6i L-ARABINITOL
4-DEHYDROGENASE

(Neurospora
crassa) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ILE A 355
LEU A 193
MET A 196
LEU A 197
 None
 0.90A 5u4sA-3m6iA:
8.4		 5u4sA-3m6iA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzb NICKEL-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		4 ILE A 467
LEU A 251
MET A 392
LEU A 253
 None
 0.90A 5u4sA-3mzbA:
undetectable		 5u4sA-3mzbA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		4 SER A 380
ILE A 381
LEU A 377
LEU A 352
 None
 0.95A 5u4sA-3na0A:
undetectable		 5u4sA-3na0A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ncv DNA MISMATCH REPAIR
PROTEIN MUTL

(Neisseria
gonorrhoeae) 		PF08676
(MutL_C) 		4 ILE A 608
LEU A 622
MET A 626
LEU A 623
 None
 1.01A 5u4sA-3ncvA:
undetectable		 5u4sA-3ncvA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngx BIFUNCTIONAL PROTEIN
FOLD

(Thermoplasma
acidophilum) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 ILE A  57
LEU A  30
MET A  89
LEU A  32
 None
 0.91A 5u4sA-3ngxA:
undetectable		 5u4sA-3ngxA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odp PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE

(Clostridium
novyi) 		PF01380
(SIS) 		4 ASN A  51
SER A 138
ILE A 137
PRO A 108
 None
 0.99A 5u4sA-3odpA:
2.1		 5u4sA-3odpA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 ILE B 250
LEU B 246
MET B 291
LEU B 241
 None
 0.71A 5u4sA-3ohmB:
undetectable		 5u4sA-3ohmB:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3okz PUTATIVE
UNCHARACTERIZED
PROTEIN GBS0355

(Streptococcus
agalactiae) 		PF03816
(LytR_cpsA_psr) 		4 SER A 209
LEU A 206
MET A 157
LEU A 160
 None
 0.96A 5u4sA-3okzA:
undetectable		 5u4sA-3okzA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pam TRANSMEMBRANE
PROTEIN

(Bartonella
henselae) 		PF00496
(SBP_bac_5) 		4 ASN A 501
SER A 369
ILE A 370
LEU A 371
 None
 1.02A 5u4sA-3pamA:
undetectable		 5u4sA-3pamA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pt3 E3 UBIQUITIN-PROTEIN
LIGASE UBR5

(Homo sapiens) 		PF00632
(HECT) 		4 ASN A2703
SER A2700
ILE A2754
LEU A2776
 None
 1.01A 5u4sA-3pt3A:
undetectable		 5u4sA-3pt3A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pua PHD FINGER PROTEIN 2

(Homo sapiens) 		PF02373
(JmjC) 		4 ILE A 401
LEU A 402
MET A 373
LEU A 377
 None
 0.99A 5u4sA-3puaA:
undetectable		 5u4sA-3puaA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbw ANHYDRO-N-ACETYLMURA
MIC ACID KINASE

(Pseudomonas
aeruginosa) 		PF03702
(AnmK) 		4 SER A  93
ILE A  91
LEU A   7
MET A  16
 None
 0.97A 5u4sA-3qbwA:
undetectable		 5u4sA-3qbwA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qde CELLOBIOSE
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 SER A 460
ILE A 421
LEU A 457
MET A 453
 None
 0.93A 5u4sA-3qdeA:
undetectable		 5u4sA-3qdeA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrt FUSION GLYCOPROTEIN
F0

(Human
orthopneumovirus) 		PF00523
(Fusion_gly) 		4 ILE B 261
LEU B 257
LEU B 252
PRO B 304
 None
 0.81A 5u4sA-3rrtB:
undetectable		 5u4sA-3rrtB:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Hoeflea
phototrophica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 259
LEU A 299
LEU A 300
PRO A 257
 None
 0.89A 5u4sA-3t8qA:
undetectable		 5u4sA-3t8qA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcs RACEMASE, PUTATIVE

(Roseobacter
denitrificans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 259
LEU A 299
LEU A 300
PRO A 257
 None
 0.90A 5u4sA-3tcsA:
undetectable		 5u4sA-3tcsA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Roseovarius
nubinhibens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 259
LEU A 299
LEU A 300
PRO A 257
 None
 0.90A 5u4sA-3u4fA:
undetectable		 5u4sA-3u4fA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uar GLUTATHIONE
S-TRANSFERASE

(Methylococcus
capsulatus) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 ILE A  69
LEU A  55
MET A   1
LEU A  57
 None
 0.83A 5u4sA-3uarA:
undetectable		 5u4sA-3uarA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7n THREONINE SYNTHASE

(Burkholderia
thailandensis) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 ASN A 259
ILE A 288
LEU A 286
LEU A  45
 None
 0.90A 5u4sA-3v7nA:
2.0		 5u4sA-3v7nA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgo E3 UBIQUITIN-PROTEIN
LIGASE CBL-B

(Homo sapiens) 		PF02262
(Cbl_N)
PF02761
(Cbl_N2)
PF02762
(Cbl_N3) 		4 SER A 151
ILE A  77
LEU A 292
PRO A  71
 None
 0.96A 5u4sA-3vgoA:
undetectable		 5u4sA-3vgoA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpo RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2

(Homo sapiens) 		PF00268
(Ribonuc_red_sm) 		4 ILE A 313
LEU A 246
MET A 252
LEU A 255
 None
 0.93A 5u4sA-3vpoA:
undetectable		 5u4sA-3vpoA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Thermus
thermophilus) 		PF00440
(TetR_N) 		5 ASN A 111
SER A  55
ILE A  54
LEU A  51
LEU A 107
 None
 1.40A 5u4sA-3vprA:
undetectable		 5u4sA-3vprA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vqi ATG5

(Kluyveromyces
marxianus) 		PF04106
(APG5) 		4 SER A 228
ILE A 229
LEU A 225
LEU A 220
 None
 0.83A 5u4sA-3vqiA:
undetectable		 5u4sA-3vqiA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A

(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		PF00004
(AAA) 		4 ILE A 286
LEU A 308
MET A 312
LEU A 309
 ILE  A 286 ( 0.7A)
LEU  A 308 ( 0.6A)
MET  A 312 ( 0.0A)
LEU  A 309 ( 0.6A)
 1.02A 5u4sA-3whlA:
undetectable		 5u4sA-3whlA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiq KOJIBIOSE
PHOSPHORYLASE

(Caldicellulosiruptor
saccharolyticus) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 SER A 450
ILE A 453
LEU A 508
LEU A 512
 None
 0.97A 5u4sA-3wiqA:
undetectable		 5u4sA-3wiqA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Caenorhabditis
elegans) 		PF13649
(Methyltransf_25) 		4 ILE A  37
LEU A  77
MET A  81
LEU A  78
 None
None
None
SAH  A 701 (-3.9A)
 0.78A 5u4sA-3wstA:
4.6		 5u4sA-3wstA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A

(Saccharomyces
cerevisiae) 		PF16787
(NDC10_II) 		4 SER A 189
ILE A 280
LEU A 185
PRO A 282
 None
 0.96A 5u4sA-4acoA:
undetectable		 5u4sA-4acoA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bf5 ALANINE RACEMASE

(Aeromonas
hydrophila) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 ILE A 164
LEU A 227
LEU A 228
PRO A 198
 None
 1.02A 5u4sA-4bf5A:
undetectable		 5u4sA-4bf5A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0h MRNA CLEAVAGE AND
POLYADENYLATION
FACTOR CLP1

(Saccharomyces
cerevisiae) 		PF06807
(Clp1)
PF16573
(CLP1_N)
PF16575
(CLP1_P) 		4 ILE A 307
LEU A 109
MET A 112
LEU A 113
 None
 0.99A 5u4sA-4c0hA:
2.4		 5u4sA-4c0hA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0n 2-ON-2 HEMOGLOBIN

(Arabidopsis
thaliana) 		PF01152
(Bac_globin) 		4 SER A 122
ILE A 125
LEU A 119
MET A 115
 None
 0.96A 5u4sA-4c0nA:
undetectable		 5u4sA-4c0nA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4co6 NUCLEOPROTEIN

(Nipah
henipavirus) 		PF00973
(Paramyxo_ncap) 		4 ILE A 174
LEU A 175
MET A 217
LEU A 221
 None
 1.01A 5u4sA-4co6A:
undetectable		 5u4sA-4co6A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7w SORTASE FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF04203
(Sortase) 		4 ASN A  68
ILE A  60
LEU A  92
LEU A 135
 None
 1.03A 5u4sA-4d7wA:
undetectable		 5u4sA-4d7wA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli) 		PF05175
(MTS) 		4 ASN A 206
SER A  99
ILE A  70
LEU A 120
 None
 0.96A 5u4sA-4dcmA:
7.1		 5u4sA-4dcmA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN

(Francisella
tularensis) 		PF13561
(adh_short_C2) 		5 ASN A 163
ILE A 234
LEU A 215
LEU A 219
PRO A 233
 None
 1.36A 5u4sA-4e4yA:
24.3		 5u4sA-4e4yA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4elj RETINOBLASTOMA-ASSOC
IATED PROTEIN

(Homo sapiens) 		PF01857
(RB_B)
PF01858
(RB_A)
PF11934
(DUF3452) 		4 ILE A 401
LEU A 400
MET A 457
LEU A 461
 None
 1.03A 5u4sA-4eljA:
undetectable		 5u4sA-4eljA:
16.03