SIMILAR PATTERNS OF AMINO ACIDS FOR 5TZO_C_7V7C202_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1axk GLUXYN-1

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11)
PF00722
(Glyco_hydro_16) 		5 TYR A 264
THR A 266
ARG A 268
GLN A 283
TRP A 285
 None
 0.43A 5tzoC-1axkA:
34.5		 5tzoC-1axkA:
58.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1f5j BETA-1,4-XYLANASE

(Dictyoglomus
thermophilum) 		PF00457
(Glyco_hydro_11) 		4 TRP A 100
THR A 123
ARG A 125
GLN A 139
 None
 1.27A 5tzoC-1f5jA:
25.2		 5tzoC-1f5jA:
42.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1f5j BETA-1,4-XYLANASE

(Dictyoglomus
thermophilum) 		PF00457
(Glyco_hydro_11) 		5 TYR A 121
THR A 123
ARG A 125
GLN A 139
TRP A 141
 None
 0.86A 5tzoC-1f5jA:
25.2		 5tzoC-1f5jA:
42.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gw1 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Cellvibrio
japonicus) 		PF02156
(Glyco_hydro_26) 		4 TRP A 220
TRP A 219
TYR A 184
THR A 112
 None
 1.40A 5tzoC-1gw1A:
undetectable		 5tzoC-1gw1A:
18.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h1a ENDO-1,4-BETA-XYLANA
SE

(Chaetomium
thermophilum) 		PF00457
(Glyco_hydro_11) 		5 THR A 101
TYR A 119
THR A 121
GLN A 137
TRP A 139
 None
 0.88A 5tzoC-1h1aA:
28.7		 5tzoC-1h1aA:
52.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h1a ENDO-1,4-BETA-XYLANA
SE

(Chaetomium
thermophilum) 		PF00457
(Glyco_hydro_11) 		5 TYR A 119
THR A 121
ARG A 123
GLN A 137
TRP A 139
 None
None
GOL  A1196 (-2.8A)
None
None
 1.22A 5tzoC-1h1aA:
28.7		 5tzoC-1h1aA:
52.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hix ENDO-1,4-BETA-XYLANA
SE

(Streptomyces
sp. S38) 		PF00457
(Glyco_hydro_11) 		5 TYR A 117
THR A 119
ARG A 121
GLN A 135
TRP A 137
 None
 0.43A 5tzoC-1hixA:
27.6		 5tzoC-1hixA:
54.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1igo FAMILY 11 XYLANASE

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11) 		4 THR A 109
ARG A 128
GLN A 142
TRP A 144
 None
 1.38A 5tzoC-1igoA:
25.2		 5tzoC-1igoA:
48.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1igo FAMILY 11 XYLANASE

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11) 		5 TYR A 124
THR A 126
ARG A 128
GLN A 142
TRP A 144
 None
 0.65A 5tzoC-1igoA:
25.2		 5tzoC-1igoA:
48.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1imv PIGMENT
EPITHELIUM-DERIVED
FACTOR

(Homo sapiens) 		PF00079
(Serpin) 		4 THR A  67
TYR A 142
THR A 144
ARG A 121
 None
 1.33A 5tzoC-1imvA:
undetectable		 5tzoC-1imvA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		4 THR A 209
THR A 985
ARG A 913
GLN A1047
 None
 1.03A 5tzoC-1k32A:
undetectable		 5tzoC-1k32A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		4 TRP A 214
THR A 985
ARG A 913
GLN A1047
 None
 1.33A 5tzoC-1k32A:
undetectable		 5tzoC-1k32A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqj A/G-SPECIFIC ADENINE
GLYCOSYLASE

(Escherichia
coli) 		PF00633
(HHH)
PF00730
(HhH-GPD) 		4 TRP A  77
THR A  78
TYR A  51
ARG A  58
 None
None
None
GOL  A 302 (-2.9A)
 1.34A 5tzoC-1kqjA:
undetectable		 5tzoC-1kqjA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ks5 ENDOGLUCANASE A

(Aspergillus
niger) 		PF01670
(Glyco_hydro_12) 		4 TRP A  45
THR A 203
TYR A  61
GLN A  19
 None
 1.05A 5tzoC-1ks5A:
16.5		 5tzoC-1ks5A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qju PROTEIN VP1

(Rhinovirus A) 		PF00073
(Rhv) 		4 THR 1 216
TYR 1 144
ARG 1 220
GLN 1 141
 None
W01  17001 (-4.0A)
None
None
 1.28A 5tzoC-1qju1:
undetectable		 5tzoC-1qju1:
19.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1te1 ENDO-1,4-XYLANASE

(Talaromyces
funiculosus) 		PF00457
(Glyco_hydro_11) 		4 TYR B 117
ARG B 121
GLN B 135
TRP B 137
 None
 1.17A 5tzoC-1te1B:
26.7		 5tzoC-1te1B:
45.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tr7 FIMH PROTEIN

(Escherichia
coli) 		no annotation 4 TRP B 103
THR B  57
TYR B  77
ARG B  60
 None
 1.09A 5tzoC-1tr7B:
undetectable		 5tzoC-1tr7B:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u69 HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF06983
(3-dmu-9_3-mt) 		4 THR A 119
THR A  88
ARG A 147
GLN A  85
 None
 1.21A 5tzoC-1u69A:
undetectable		 5tzoC-1u69A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u9c APC35852

(Geobacillus
stearothermophilus) 		PF01965
(DJ-1_PfpI) 		4 THR A 148
THR A 150
ARG A 183
GLN A 201
 None
 1.38A 5tzoC-1u9cA:
undetectable		 5tzoC-1u9cA:
20.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yna ENDO-1,4-BETA-XYLANA
SE

(Thermomyces
lanuginosus) 		PF00457
(Glyco_hydro_11) 		4 THR A 120
ARG A 122
GLN A 136
TRP A 138
 None
 0.42A 5tzoC-1ynaA:
27.5		 5tzoC-1ynaA:
44.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3i SIMILAR TO
RAD54-LIKE

(Danio rerio) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		4 THR X 618
THR X 669
ARG X 672
GLN X 627
 None
 1.41A 5tzoC-1z3iX:
undetectable		 5tzoC-1z3iX:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlp PETAL DEATH PROTEIN

(Dianthus
caryophyllus) 		PF13714
(PEP_mutase) 		4 THR A 180
TYR A 198
THR A 206
ARG A 228
 None
 1.26A 5tzoC-1zlpA:
undetectable		 5tzoC-1zlpA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0j GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 2

(Homo sapiens) 		PF03360
(Glyco_transf_43) 		4 THR A 189
TYR A 190
THR A 104
GLN A 107
 None
 1.13A 5tzoC-2d0jA:
undetectable		 5tzoC-2d0jA:
19.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f6b FAMILY 11 XYLANASE

(Bacillus) 		PF00457
(Glyco_hydro_11) 		5 TYR A 125
THR A 127
ARG A 129
GLN A 143
TRP A 145
 None
 0.51A 5tzoC-2f6bA:
25.0		 5tzoC-2f6bA:
47.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpn YWMB

(Bacillus
subtilis) 		PF08680
(DUF1779) 		4 THR A  68
TYR A  67
THR A  66
ARG A  77
 None
 1.33A 5tzoC-2fpnA:
undetectable		 5tzoC-2fpnA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT

(Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 TRP A 471
THR A 231
THR A 807
ARG A 811
 None
 1.39A 5tzoC-2ivfA:
undetectable		 5tzoC-2ivfA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j89 METHIONINE SULFOXIDE
REDUCTASE A

(Populus
trichocarpa) 		PF01625
(PMSR) 		4 THR A 137
TYR A 135
ARG A  92
GLN A  41
 None
 1.26A 5tzoC-2j89A:
undetectable		 5tzoC-2j89A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lpu KMATG10

(Kluyveromyces
marxianus) 		PF03987
(Autophagy_act_C) 		4 TRP A  21
THR A  19
ARG A  26
GLN A  35
 None
 1.33A 5tzoC-2lpuA:
undetectable		 5tzoC-2lpuA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6x SECRETED CATHEPSIN L
1

(Fasciola
hepatica) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		4 THR A 269
TYR A 275
ARG A 298
GLN A 249
 None
 1.02A 5tzoC-2o6xA:
undetectable		 5tzoC-2o6xA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Desulfovibrio
vulgaris) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 TRP B  41
TYR B  63
THR B  64
ARG B  94
 None
None
None
SH0  A 503 (-2.7A)
 1.33A 5tzoC-2v4jB:
undetectable		 5tzoC-2v4jB:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vcl CYANOBACTERIAL
PHYCOERYTHROBILIN

(Prochlorococcus
phage P-SSM2) 		PF05996
(Fe_bilin_red) 		4 TRP A  47
THR A  62
ARG A  75
TRP A  44
 None
 1.21A 5tzoC-2vclA:
undetectable		 5tzoC-2vclA:
20.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vul GH11 XYLANASE

(Escherichia
coli) 		PF00457
(Glyco_hydro_11) 		4 TYR A 122
ARG A 126
GLN A 140
TRP A 142
 None
 0.61A 5tzoC-2vulA:
28.4		 5tzoC-2vulA:
51.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		4 THR A  99
THR A 275
ARG A 257
GLN A  91
 None
 1.30A 5tzoC-2xh1A:
undetectable		 5tzoC-2xh1A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsj SULFITE REDUCTASE
BETA SUBUNIT

(Desulfomicrobium
norvegicum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
PF12838
(Fer4_7) 		4 TRP B  41
TYR B  63
THR B  64
ARG B  94
 None
None
None
SRM  A 503 (-2.7A)
 1.36A 5tzoC-2xsjB:
undetectable		 5tzoC-2xsjB:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2u UPF0026 PROTEIN
MJ0257

(Methanocaldococcus
jannaschii) 		PF04055
(Radical_SAM)
PF08608
(Wyosine_form) 		4 TRP A  61
TRP A  89
TYR A 142
THR A  56
 None
 1.27A 5tzoC-2z2uA:
undetectable		 5tzoC-2z2uA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahy BETA-GLUCOSIDASE

(Trichoderma
reesei) 		PF00232
(Glyco_hydro_1) 		4 THR A 370
TYR A 298
THR A 299
ARG A 341
 None
TRS  A 500 (-4.1A)
None
None
 1.29A 5tzoC-3ahyA:
undetectable		 5tzoC-3ahyA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aih PROTEIN OS-9

(Homo sapiens) 		PF07915
(PRKCSH) 		4 TRP A 118
THR A 114
TYR A 120
GLN A 129
 MAN  A 301 (-3.8A)
None
None
None
 1.35A 5tzoC-3aihA:
undetectable		 5tzoC-3aihA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cuc PROTEIN OF UNKNOWN
FUNCTION WITH A FIC
DOMAIN

(Bacteroides
thetaiotaomicron) 		PF02661
(Fic) 		4 TRP A  27
THR A 270
GLN A  17
TRP A  13
 None
 1.41A 5tzoC-3cucA:
undetectable		 5tzoC-3cucA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvd PLASTOCYANIN

(Phormidium
laminosum) 		PF00127
(Copper-bind) 		4 THR A 102
TYR A  85
THR A  86
GLN A  47
 None
 1.18A 5tzoC-3cvdA:
undetectable		 5tzoC-3cvdA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djl PROTEIN AIDB

(Escherichia
coli) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		4 THR A 298
THR A 378
ARG A 375
TRP A 362
 None
 1.40A 5tzoC-3djlA:
undetectable		 5tzoC-3djlA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dnf 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE

(Aquifex
aeolicus) 		PF02401
(LYTB) 		4 THR A 166
THR A 196
ARG A 226
GLN A 200
 None
 1.38A 5tzoC-3dnfA:
undetectable		 5tzoC-3dnfA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 TYR A 176
THR A 178
ARG A 278
GLN A 357
 None
None
NO3  A5658 (-4.0A)
NO3  A5658 (-3.1A)
 1.08A 5tzoC-3hrdA:
undetectable		 5tzoC-3hrdA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if2 AMINOTRANSFERASE

(Psychrobacter
arcticus) 		PF00155
(Aminotran_1_2) 		4 THR A 151
THR A 218
ARG A 415
TRP A 368
 None
 1.28A 5tzoC-3if2A:
undetectable		 5tzoC-3if2A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iln LAMINARINASE

(Rhodothermus
marinus) 		PF00722
(Glyco_hydro_16) 		4 TRP A 230
TRP A 107
THR A 146
GLN A 159
 None
GOL  A 300 (-3.4A)
None
None
 1.41A 5tzoC-3ilnA:
5.3		 5tzoC-3ilnA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv1 P22 PROTEIN

(Trypanosoma
brucei) 		PF02330
(MAM33) 		4 TRP A  79
THR A  80
THR A  91
GLN A 104
 None
 1.34A 5tzoC-3jv1A:
undetectable		 5tzoC-3jv1A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4z GLYCOSIDE HYDROLASE
FAMILY 9

(Ruminiclostridium
thermocellum) 		PF02018
(CBM_4_9)
PF02927
(CelD_N) 		4 TYR A 100
THR A 148
ARG A  73
GLN A  71
 None
None
CBI  A 294 (-3.2A)
CBI  A 294 (-3.0A)
 1.36A 5tzoC-3k4zA:
undetectable		 5tzoC-3k4zA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN

(Bacteroides
thetaiotaomicron) 		PF01823
(MACPF) 		4 TYR A 556
THR A 419
ARG A 420
GLN A 421
 None
 1.38A 5tzoC-3kk7A:
undetectable		 5tzoC-3kk7A:
17.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lb9 ENDO-1,4-BETA-XYLANA
SE

(Bacillus
circulans) 		PF00457
(Glyco_hydro_11) 		4 THR A 156
THR A 175
ARG A 177
GLN A   6
 None
 0.86A 5tzoC-3lb9A:
12.5		 5tzoC-3lb9A:
60.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lb9 ENDO-1,4-BETA-XYLANA
SE

(Bacillus
circulans) 		PF00457
(Glyco_hydro_11) 		5 TYR A 173
THR A 175
ARG A 177
GLN A   6
TRP A   8
 None
 0.54A 5tzoC-3lb9A:
12.5		 5tzoC-3lb9A:
60.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mf9 ENDO-1,4-BETA-XYLANA
SE

(Thermopolyspora
flexuosa) 		PF00457
(Glyco_hydro_11) 		4 THR A 101
THR A 120
ARG A 122
GLN A 136
 None
 1.01A 5tzoC-3mf9A:
27.8		 5tzoC-3mf9A:
56.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mf9 ENDO-1,4-BETA-XYLANA
SE

(Thermopolyspora
flexuosa) 		PF00457
(Glyco_hydro_11) 		5 TYR A 118
THR A 120
ARG A 122
GLN A 136
TRP A 138
 None
 0.66A 5tzoC-3mf9A:
27.8		 5tzoC-3mf9A:
56.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qv9 PYRUVATE KINASE 2

(Trypanosoma
cruzi) 		PF00224
(PK)
PF02887
(PK_C) 		4 THR A 424
THR A 428
ARG A 427
GLN A 431
 None
 1.38A 5tzoC-3qv9A:
undetectable		 5tzoC-3qv9A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3saj GLUTAMATE RECEPTOR 1

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 THR A 347
TYR A 346
ARG A 327
GLN A 336
 None
None
NAG  A 800 ( 3.1A)
NAG  A 800 (-3.1A)
 1.22A 5tzoC-3sajA:
undetectable		 5tzoC-3sajA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4v INTEGRIN BETA-7

(Homo sapiens) 		PF00362
(Integrin_beta) 		4 THR B 419
ARG B 124
GLN B 122
TRP B 421
 None
 1.37A 5tzoC-3v4vB:
undetectable		 5tzoC-3v4vB:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsv XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF13229
(Beta_helix) 		4 TRP A  82
TYR A 105
ARG A  91
GLN A  93
 None
 1.41A 5tzoC-3vsvA:
undetectable		 5tzoC-3vsvA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vta CUCUMISIN

(Cucumis melo) 		PF00082
(Peptidase_S8) 		4 TRP A 246
THR A 141
THR A 201
ARG A 199
 None
 1.41A 5tzoC-3vtaA:
undetectable		 5tzoC-3vtaA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vz0 PUTATIVE
NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF00171
(Aldedh) 		4 THR A  13
THR A   6
ARG A  16
GLN A 163
 None
 1.25A 5tzoC-3vz0A:
undetectable		 5tzoC-3vz0A:
17.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vzm ENDO-1,4-BETA-XYLANA
SE

(Bacillus
circulans) 		PF00457
(Glyco_hydro_11) 		4 THR A  91
THR A 110
ARG A 112
GLN A 127
 None
None
DFX  A 201 (-3.9A)
DFX  A 201 (-4.3A)
 0.81A 5tzoC-3vzmA:
35.1		 5tzoC-3vzmA:
91.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vzm ENDO-1,4-BETA-XYLANA
SE

(Bacillus
circulans) 		PF00457
(Glyco_hydro_11) 		5 TYR A 108
THR A 110
ARG A 112
GLN A 127
TRP A 129
 None
None
DFX  A 201 (-3.9A)
DFX  A 201 (-4.3A)
None
 0.38A 5tzoC-3vzmA:
35.1		 5tzoC-3vzmA:
91.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zse ENDO-1,4-BETA-XYLANA
SE

(Thermobifida
fusca) 		PF00457
(Glyco_hydro_11) 		4 THR A 140
THR A 159
ARG A 161
GLN A 175
 None
None
FXP  A1207 (-4.1A)
FXP  A1207 (-4.3A)
 0.78A 5tzoC-3zseA:
28.4		 5tzoC-3zseA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zse ENDO-1,4-BETA-XYLANA
SE

(Thermobifida
fusca) 		PF00457
(Glyco_hydro_11) 		5 TYR A 157
THR A 159
ARG A 161
GLN A 175
TRP A 177
 None
None
FXP  A1207 (-4.1A)
FXP  A1207 (-4.3A)
None
 0.43A 5tzoC-3zseA:
28.4		 5tzoC-3zseA:
55.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4frx ANAEROBICALLY-INDUCE
D OUTER MEMBRANE
PORIN OPRE

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 THR A 145
THR A 143
ARG A 114
GLN A 141
 None
 1.29A 5tzoC-4frxA:
undetectable		 5tzoC-4frxA:
19.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hk9 ENDO-1,4-BETA-XYLANA
SE 2

(Trichoderma
reesei) 		PF00457
(Glyco_hydro_11) 		6 THR A 100
TYR A 118
THR A 120
ARG A 122
GLN A 136
TRP A 138
 None
None
None
XYP  A 203 (-3.7A)
XYP  A 203 (-4.0A)
None
 0.91A 5tzoC-4hk9A:
29.1		 5tzoC-4hk9A:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ixl XYLANASE

(Bacillus sp.
(in: Bacteria)) 		PF00457
(Glyco_hydro_11) 		4 TYR A 124
ARG A 128
GLN A 142
TRP A 144
 None
 0.81A 5tzoC-4ixlA:
24.5		 5tzoC-4ixlA:
41.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ixl XYLANASE

(Bacillus sp.
(in: Bacteria)) 		PF00457
(Glyco_hydro_11) 		4 TYR A 124
THR A 126
GLN A 142
TRP A 144
 None
 0.62A 5tzoC-4ixlA:
24.5		 5tzoC-4ixlA:
41.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5r OXYGENASE

(Streptomyces
argillaceus) 		PF01494
(FAD_binding_3) 		4 THR A 105
THR A  60
ARG A  59
GLN A 310
 None
 1.29A 5tzoC-4k5rA:
undetectable		 5tzoC-4k5rA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7w HD DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF13023
(HD_3) 		4 TRP A  35
TYR A 168
THR A 171
GLN A 144
 None
 1.41A 5tzoC-4l7wA:
undetectable		 5tzoC-4l7wA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdp BETA-GLUCOSIDASE

(Humicola grisea) 		PF00232
(Glyco_hydro_1) 		4 THR A 380
TYR A 308
THR A 309
ARG A 351
 None
GOL  A 507 (-4.1A)
None
None
 1.18A 5tzoC-4mdpA:
undetectable		 5tzoC-4mdpA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6d TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Desulfovibrio
salexigens) 		PF03480
(DctP) 		4 THR A 118
THR A 266
ARG A  50
GLN A 262
 None
 1.36A 5tzoC-4n6dA:
undetectable		 5tzoC-4n6dA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofd KIN OF IRRE-LIKE
PROTEIN 1

(Mus musculus) 		PF07679
(I-set)
PF08205
(C2-set_2) 		4 TRP A  57
THR A  58
TYR A 102
ARG A 114
 None
 1.34A 5tzoC-4ofdA:
undetectable		 5tzoC-4ofdA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pgj HUMAN HEAVY CHAIN
DOMAIN ANTIBODY

(Homo sapiens) 		PF07686
(V-set) 		4 TRP A 111
TYR A 110
THR A 100
GLN A 104
 None
 1.32A 5tzoC-4pgjA:
undetectable		 5tzoC-4pgjA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pju COHESIN SUBUNIT SA-2
DOUBLE-STRAND-BREAK
REPAIR PROTEIN RAD21
HOMOLOG

(Homo sapiens) 		PF08514
(STAG)
no annotation 		4 TRP B 381
THR A 626
THR A 586
GLN A 590
 None
 1.39A 5tzoC-4pjuB:
undetectable		 5tzoC-4pjuB:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4y COXSACKIEVIRUS
CAPSID PROTEIN VP1

(Enterovirus C) 		PF00073
(Rhv) 		4 THR 1 241
TYR 1 161
ARG 1 245
GLN 1 158
 None
None
CL  15008 (-3.6A)
None
 1.28A 5tzoC-4q4y1:
undetectable		 5tzoC-4q4y1:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rep GAMMA-CAROTENE
DESATURASE

(Nonlabens
dokdonensis) 		PF01593
(Amino_oxidase) 		4 TRP A 309
THR A 410
ARG A 313
TRP A 368
 None
GOL  A 502 ( 4.1A)
None
None
 1.41A 5tzoC-4repA:
undetectable		 5tzoC-4repA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN

(Mycolicibacterium
fortuitum) 		PF00722
(Glyco_hydro_16) 		4 THR A 220
TYR A 219
THR A 203
ARG A 140
 THR  A 220 ( 0.8A)
TYR  A 219 ( 1.3A)
THR  A 203 ( 0.8A)
ARG  A 140 ( 0.6A)
 1.05A 5tzoC-4w65A:
5.6		 5tzoC-4w65A:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6y NANOBODY NBFEDF9

(Lama glama) 		PF07686
(V-set) 		4 THR B  28
TYR B  29
THR B  53
ARG B  54
 None
 1.29A 5tzoC-4w6yB:
undetectable		 5tzoC-4w6yB:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE

(Geobacillus
stearothermophilus) 		PF00232
(Glyco_hydro_1) 		4 TRP A  15
THR A 473
ARG A 403
GLN A 407
 None
 1.22A 5tzoC-4zfmA:
undetectable		 5tzoC-4zfmA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7m BETA-XYLOSIDASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 TRP A 280
THR A 274
GLN A 230
TRP A 763
 None
ZN  A1909 ( 4.4A)
None
None
 1.31A 5tzoC-5a7mA:
undetectable		 5tzoC-5a7mA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxp LACTO-N-BIOSIDASE

(Bifidobacterium
bifidum) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF14200
(RicinB_lectin_2) 		4 TRP A 610
THR A 607
THR A 627
GLN A 629
 None
 1.17A 5tzoC-5bxpA:
undetectable		 5tzoC-5bxpA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
ALPHA SUBUNIT

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 4 TRP A 458
TYR A 554
ARG A 490
GLN A 557
 None
 1.33A 5tzoC-5c2vA:
undetectable		 5tzoC-5c2vA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c8c VP1

(Enterovirus A) 		PF00073
(Rhv) 		4 THR A 232
TYR A 155
ARG A 236
GLN A 152
 None
STE  A 301 ( 4.5A)
None
None
 1.32A 5tzoC-5c8cA:
undetectable		 5tzoC-5c8cA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cd6 TPR-DOMAIN
CONTAINING PROTEIN

(Parabacteroides
distasonis) 		PF17128
(DUF5107) 		4 TRP A 299
THR A 560
TYR A 561
THR A 564
 None
 1.19A 5tzoC-5cd6A:
undetectable		 5tzoC-5cd6A:
14.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ej3 ENDO-1,4-BETA-XYLANA
SE B

(Streptomyces
lividans) 		PF00457
(Glyco_hydro_11) 		5 TYR A 117
THR A 119
ARG A 121
GLN A 135
TRP A 137
 None
 0.70A 5tzoC-5ej3A:
27.5		 5tzoC-5ej3A:
49.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyy CENTROLOBIUM
TOMENTOSUM LECTIN

(Centrolobium
tomentosum) 		PF00139
(Lectin_legB) 		4 THR A 183
TYR A 177
THR A 176
GLN A  71
 None
 1.02A 5tzoC-5eyyA:
5.0		 5tzoC-5eyyA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1

(Caenorhabditis
elegans;
Homo sapiens) 		PF00090
(TSP_1)
PF10250
(O-FucT) 		4 TRP A 141
TYR A 145
ARG A1025
GLN A1042
 None
 1.34A 5tzoC-5foeA:
undetectable		 5tzoC-5foeA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxf ACRYLYL-COA
REDUCTASE ACUI

(Ruegeria
pomeroyi) 		PF00107
(ADH_zinc_N) 		4 THR A 156
ARG A 231
GLN A 235
TRP A 217
 None
 1.22A 5tzoC-5gxfA:
undetectable		 5tzoC-5gxfA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hi8 ANTENNA PROTEIN

(Prochlorococcus
phage P-HM1) 		PF06206
(CpeT) 		4 TYR A  41
THR A  43
ARG A  55
GLN A  57
 None
None
None
ACT  A 202 (-3.8A)
 1.21A 5tzoC-5hi8A:
undetectable		 5tzoC-5hi8A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbk BETA-GLUCOSIDASE

(Trichoderma
harzianum) 		PF00232
(Glyco_hydro_1) 		4 THR A 370
TYR A 298
THR A 299
ARG A 341
 None
GOL  A 501 (-4.1A)
None
None
 1.23A 5tzoC-5jbkA:
undetectable		 5tzoC-5jbkA:
18.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jrm ENDO-1,4-BETA-XYLANA
SE

(Fusarium
oxysporum) 		PF00457
(Glyco_hydro_11) 		4 TYR A 117
ARG A 121
GLN A 135
TRP A 137
 None
 0.67A 5tzoC-5jrmA:
27.5		 5tzoC-5jrmA:
47.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldn HEXON PROTEIN,HEXON
CAPSID

(Human
mastadenovirus
C) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		4 TRP A 677
TRP A 730
THR A 885
ARG A 675
 None
 1.29A 5tzoC-5ldnA:
undetectable		 5tzoC-5ldnA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5njf METALLOPROTEASE PMBA

(Escherichia
coli) 		PF01523
(PmbA_TldD) 		4 THR B 290
THR B 325
ARG B 316
GLN B 326
 None
 1.09A 5tzoC-5njfB:
undetectable		 5tzoC-5njfB:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u38 LECTIN

(Platypodium
elegans) 		PF00139
(Lectin_legB) 		4 THR A 183
TYR A 177
THR A 176
GLN A  71
 None
 1.37A 5tzoC-5u38A:
undetectable		 5tzoC-5u38A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqj EXO-BETA-1,4-XYLANAS
E

(unidentified) 		no annotation 4 TYR A 129
ARG A 133
GLN A 147
TRP A 149
 None
 1.05A 5tzoC-5vqjA:
23.9		 5tzoC-5vqjA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME

(uncultured
organism) 		no annotation 4 THR A 116
TYR A 122
THR A 124
GLN A 126
 None
 1.38A 5tzoC-5wh8A:
undetectable		 5tzoC-5wh8A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1t PPKA-294

(Serratia sp.
FS14) 		no annotation 4 TYR A 227
THR A 224
ARG A 164
GLN A 220
 None
 1.32A 5tzoC-5x1tA:
undetectable		 5tzoC-5x1tA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3r PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 4 TRP A1730
THR A1732
THR A1737
GLN A1789
 None
 0.91A 5tzoC-6b3rA:
undetectable		 5tzoC-6b3rA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfu SPIKE PROTEIN

(Coronavirus
HKU15) 		no annotation 4 THR A 444
TYR A 436
ARG A 292
GLN A 293
 None
 1.33A 5tzoC-6bfuA:
undetectable		 5tzoC-6bfuA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpz PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,MOUSE
PIEZO1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 4 TRP A1730
THR A1732
THR A1737
GLN A1789
 None
 1.10A 5tzoC-6bpzA:
undetectable		 5tzoC-6bpzA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eks SIALIDASE

(Vibrio cholerae) 		no annotation 4 TRP A 553
THR A 554
TYR A 394
GLN A 423
 None
 1.37A 5tzoC-6eksA:
undetectable		 5tzoC-6eksA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9n CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 1

(Homo sapiens) 		no annotation 4 TYR A 701
THR A 782
GLN A 798
TRP A 784
 None
 1.20A 5tzoC-6f9nA:
undetectable		 5tzoC-6f9nA:
15.96