SIMILAR PATTERNS OF AMINO ACIDS FOR 5TZO_C_7V7C202
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1axk | GLUXYN-1 (Bacillussubtilis) |
PF00457(Glyco_hydro_11)PF00722(Glyco_hydro_16) | 5 | TYR A 264THR A 266ARG A 268GLN A 283TRP A 285 | None | 0.43A | 5tzoC-1axkA:34.5 | 5tzoC-1axkA:58.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1f5j | BETA-1,4-XYLANASE (Dictyoglomusthermophilum) |
PF00457(Glyco_hydro_11) | 4 | TRP A 100THR A 123ARG A 125GLN A 139 | None | 1.27A | 5tzoC-1f5jA:25.2 | 5tzoC-1f5jA:42.56 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1f5j | BETA-1,4-XYLANASE (Dictyoglomusthermophilum) |
PF00457(Glyco_hydro_11) | 5 | TYR A 121THR A 123ARG A 125GLN A 139TRP A 141 | None | 0.86A | 5tzoC-1f5jA:25.2 | 5tzoC-1f5jA:42.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gw1 | MANNANENDO-1,4-BETA-MANNOSIDASE (Cellvibriojaponicus) |
PF02156(Glyco_hydro_26) | 4 | TRP A 220TRP A 219TYR A 184THR A 112 | None | 1.40A | 5tzoC-1gw1A:undetectable | 5tzoC-1gw1A:18.37 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1h1a | ENDO-1,4-BETA-XYLANASE (Chaetomiumthermophilum) |
PF00457(Glyco_hydro_11) | 5 | THR A 101TYR A 119THR A 121GLN A 137TRP A 139 | None | 0.88A | 5tzoC-1h1aA:28.7 | 5tzoC-1h1aA:52.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1h1a | ENDO-1,4-BETA-XYLANASE (Chaetomiumthermophilum) |
PF00457(Glyco_hydro_11) | 5 | TYR A 119THR A 121ARG A 123GLN A 137TRP A 139 | NoneNoneGOL A1196 (-2.8A)NoneNone | 1.22A | 5tzoC-1h1aA:28.7 | 5tzoC-1h1aA:52.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hix | ENDO-1,4-BETA-XYLANASE (Streptomycessp. S38) |
PF00457(Glyco_hydro_11) | 5 | TYR A 117THR A 119ARG A 121GLN A 135TRP A 137 | None | 0.43A | 5tzoC-1hixA:27.6 | 5tzoC-1hixA:54.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1igo | FAMILY 11 XYLANASE (Bacillussubtilis) |
PF00457(Glyco_hydro_11) | 4 | THR A 109ARG A 128GLN A 142TRP A 144 | None | 1.38A | 5tzoC-1igoA:25.2 | 5tzoC-1igoA:48.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1igo | FAMILY 11 XYLANASE (Bacillussubtilis) |
PF00457(Glyco_hydro_11) | 5 | TYR A 124THR A 126ARG A 128GLN A 142TRP A 144 | None | 0.65A | 5tzoC-1igoA:25.2 | 5tzoC-1igoA:48.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1imv | PIGMENTEPITHELIUM-DERIVEDFACTOR (Homo sapiens) |
PF00079(Serpin) | 4 | THR A 67TYR A 142THR A 144ARG A 121 | None | 1.33A | 5tzoC-1imvA:undetectable | 5tzoC-1imvA:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k32 | TRICORN PROTEASE (Thermoplasmaacidophilum) |
PF03572(Peptidase_S41)PF07676(PD40)PF14684(Tricorn_C1)PF14685(Tricorn_PDZ) | 4 | THR A 209THR A 985ARG A 913GLN A1047 | None | 1.03A | 5tzoC-1k32A:undetectable | 5tzoC-1k32A:10.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k32 | TRICORN PROTEASE (Thermoplasmaacidophilum) |
PF03572(Peptidase_S41)PF07676(PD40)PF14684(Tricorn_C1)PF14685(Tricorn_PDZ) | 4 | TRP A 214THR A 985ARG A 913GLN A1047 | None | 1.33A | 5tzoC-1k32A:undetectable | 5tzoC-1k32A:10.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kqj | A/G-SPECIFIC ADENINEGLYCOSYLASE (Escherichiacoli) |
PF00633(HHH)PF00730(HhH-GPD) | 4 | TRP A 77THR A 78TYR A 51ARG A 58 | NoneNoneNoneGOL A 302 (-2.9A) | 1.34A | 5tzoC-1kqjA:undetectable | 5tzoC-1kqjA:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ks5 | ENDOGLUCANASE A (Aspergillusniger) |
PF01670(Glyco_hydro_12) | 4 | TRP A 45THR A 203TYR A 61GLN A 19 | None | 1.05A | 5tzoC-1ks5A:16.5 | 5tzoC-1ks5A:23.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qju | PROTEIN VP1 (Rhinovirus A) |
PF00073(Rhv) | 4 | THR 1 216TYR 1 144ARG 1 220GLN 1 141 | NoneW01 17001 (-4.0A)NoneNone | 1.28A | 5tzoC-1qju1:undetectable | 5tzoC-1qju1:19.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1te1 | ENDO-1,4-XYLANASE (Talaromycesfuniculosus) |
PF00457(Glyco_hydro_11) | 4 | TYR B 117ARG B 121GLN B 135TRP B 137 | None | 1.17A | 5tzoC-1te1B:26.7 | 5tzoC-1te1B:45.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tr7 | FIMH PROTEIN (Escherichiacoli) |
no annotation | 4 | TRP B 103THR B 57TYR B 77ARG B 60 | None | 1.09A | 5tzoC-1tr7B:undetectable | 5tzoC-1tr7B:24.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u69 | HYPOTHETICAL PROTEIN (Pseudomonasaeruginosa) |
PF06983(3-dmu-9_3-mt) | 4 | THR A 119THR A 88ARG A 147GLN A 85 | None | 1.21A | 5tzoC-1u69A:undetectable | 5tzoC-1u69A:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u9c | APC35852 (Geobacillusstearothermophilus) |
PF01965(DJ-1_PfpI) | 4 | THR A 148THR A 150ARG A 183GLN A 201 | None | 1.38A | 5tzoC-1u9cA:undetectable | 5tzoC-1u9cA:20.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1yna | ENDO-1,4-BETA-XYLANASE (Thermomyceslanuginosus) |
PF00457(Glyco_hydro_11) | 4 | THR A 120ARG A 122GLN A 136TRP A 138 | None | 0.42A | 5tzoC-1ynaA:27.5 | 5tzoC-1ynaA:44.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z3i | SIMILAR TORAD54-LIKE (Danio rerio) |
PF00176(SNF2_N)PF00271(Helicase_C) | 4 | THR X 618THR X 669ARG X 672GLN X 627 | None | 1.41A | 5tzoC-1z3iX:undetectable | 5tzoC-1z3iX:12.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zlp | PETAL DEATH PROTEIN (Dianthuscaryophyllus) |
PF13714(PEP_mutase) | 4 | THR A 180TYR A 198THR A 206ARG A 228 | None | 1.26A | 5tzoC-1zlpA:undetectable | 5tzoC-1zlpA:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d0j | GALACTOSYLGALACTOSYLXYLOSYLPROTEIN3-BETA-GLUCURONOSYLTRANSFERASE 2 (Homo sapiens) |
PF03360(Glyco_transf_43) | 4 | THR A 189TYR A 190THR A 104GLN A 107 | None | 1.13A | 5tzoC-2d0jA:undetectable | 5tzoC-2d0jA:19.03 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2f6b | FAMILY 11 XYLANASE (Bacillus) |
PF00457(Glyco_hydro_11) | 5 | TYR A 125THR A 127ARG A 129GLN A 143TRP A 145 | None | 0.51A | 5tzoC-2f6bA:25.0 | 5tzoC-2f6bA:47.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fpn | YWMB (Bacillussubtilis) |
PF08680(DUF1779) | 4 | THR A 68TYR A 67THR A 66ARG A 77 | None | 1.33A | 5tzoC-2fpnA:undetectable | 5tzoC-2fpnA:19.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ivf | ETHYLBENZENEDEHYDROGENASEALPHA-SUBUNIT (Aromatoleumaromaticum) |
PF00384(Molybdopterin)PF01568(Molydop_binding) | 4 | TRP A 471THR A 231THR A 807ARG A 811 | None | 1.39A | 5tzoC-2ivfA:undetectable | 5tzoC-2ivfA:12.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j89 | METHIONINE SULFOXIDEREDUCTASE A (Populustrichocarpa) |
PF01625(PMSR) | 4 | THR A 137TYR A 135ARG A 92GLN A 41 | None | 1.26A | 5tzoC-2j89A:undetectable | 5tzoC-2j89A:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lpu | KMATG10 (Kluyveromycesmarxianus) |
PF03987(Autophagy_act_C) | 4 | TRP A 21THR A 19ARG A 26GLN A 35 | None | 1.33A | 5tzoC-2lpuA:undetectable | 5tzoC-2lpuA:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o6x | SECRETED CATHEPSIN L1 (Fasciolahepatica) |
PF00112(Peptidase_C1)PF08246(Inhibitor_I29) | 4 | THR A 269TYR A 275ARG A 298GLN A 249 | None | 1.02A | 5tzoC-2o6xA:undetectable | 5tzoC-2o6xA:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v4j | SULFITE REDUCTASE,DISSIMILATORY-TYPESUBUNIT BETA (Desulfovibriovulgaris) |
PF01077(NIR_SIR)PF03460(NIR_SIR_ferr) | 4 | TRP B 41TYR B 63THR B 64ARG B 94 | NoneNoneNoneSH0 A 503 (-2.7A) | 1.33A | 5tzoC-2v4jB:undetectable | 5tzoC-2v4jB:17.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vcl | CYANOBACTERIALPHYCOERYTHROBILIN (Prochlorococcusphage P-SSM2) |
PF05996(Fe_bilin_red) | 4 | TRP A 47THR A 62ARG A 75TRP A 44 | None | 1.21A | 5tzoC-2vclA:undetectable | 5tzoC-2vclA:20.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2vul | GH11 XYLANASE (Escherichiacoli) |
PF00457(Glyco_hydro_11) | 4 | TYR A 122ARG A 126GLN A 140TRP A 142 | None | 0.61A | 5tzoC-2vulA:28.4 | 5tzoC-2vulA:51.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xh1 | KYNURENINE/ALPHA-AMINOADIPATEAMINOTRANSFERASE,MITOCHONDRIAL (Homo sapiens) |
PF00155(Aminotran_1_2) | 4 | THR A 99THR A 275ARG A 257GLN A 91 | None | 1.30A | 5tzoC-2xh1A:undetectable | 5tzoC-2xh1A:16.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xsj | SULFITE REDUCTASEBETA SUBUNIT (Desulfomicrobiumnorvegicum) |
PF01077(NIR_SIR)PF03460(NIR_SIR_ferr)PF12838(Fer4_7) | 4 | TRP B 41TYR B 63THR B 64ARG B 94 | NoneNoneNoneSRM A 503 (-2.7A) | 1.36A | 5tzoC-2xsjB:undetectable | 5tzoC-2xsjB:18.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z2u | UPF0026 PROTEINMJ0257 (Methanocaldococcusjannaschii) |
PF04055(Radical_SAM)PF08608(Wyosine_form) | 4 | TRP A 61TRP A 89TYR A 142THR A 56 | None | 1.27A | 5tzoC-2z2uA:undetectable | 5tzoC-2z2uA:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ahy | BETA-GLUCOSIDASE (Trichodermareesei) |
PF00232(Glyco_hydro_1) | 4 | THR A 370TYR A 298THR A 299ARG A 341 | NoneTRS A 500 (-4.1A)NoneNone | 1.29A | 5tzoC-3ahyA:undetectable | 5tzoC-3ahyA:18.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aih | PROTEIN OS-9 (Homo sapiens) |
PF07915(PRKCSH) | 4 | TRP A 118THR A 114TYR A 120GLN A 129 | MAN A 301 (-3.8A)NoneNoneNone | 1.35A | 5tzoC-3aihA:undetectable | 5tzoC-3aihA:16.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cuc | PROTEIN OF UNKNOWNFUNCTION WITH A FICDOMAIN (Bacteroidesthetaiotaomicron) |
PF02661(Fic) | 4 | TRP A 27THR A 270GLN A 17TRP A 13 | None | 1.41A | 5tzoC-3cucA:undetectable | 5tzoC-3cucA:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cvd | PLASTOCYANIN (Phormidiumlaminosum) |
PF00127(Copper-bind) | 4 | THR A 102TYR A 85THR A 86GLN A 47 | None | 1.18A | 5tzoC-3cvdA:undetectable | 5tzoC-3cvdA:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3djl | PROTEIN AIDB (Escherichiacoli) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M) | 4 | THR A 298THR A 378ARG A 375TRP A 362 | None | 1.40A | 5tzoC-3djlA:undetectable | 5tzoC-3djlA:14.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dnf | 4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATEREDUCTASE (Aquifexaeolicus) |
PF02401(LYTB) | 4 | THR A 166THR A 196ARG A 226GLN A 200 | None | 1.38A | 5tzoC-3dnfA:undetectable | 5tzoC-3dnfA:17.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hrd | NICOTINATEDEHYDROGENASE LARGEMOLYBDOPTERINSUBUNIT (Eubacteriumbarkeri) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 4 | TYR A 176THR A 178ARG A 278GLN A 357 | NoneNoneNO3 A5658 (-4.0A)NO3 A5658 (-3.1A) | 1.08A | 5tzoC-3hrdA:undetectable | 5tzoC-3hrdA:17.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3if2 | AMINOTRANSFERASE (Psychrobacterarcticus) |
PF00155(Aminotran_1_2) | 4 | THR A 151THR A 218ARG A 415TRP A 368 | None | 1.28A | 5tzoC-3if2A:undetectable | 5tzoC-3if2A:17.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iln | LAMINARINASE (Rhodothermusmarinus) |
PF00722(Glyco_hydro_16) | 4 | TRP A 230TRP A 107THR A 146GLN A 159 | NoneGOL A 300 (-3.4A)NoneNone | 1.41A | 5tzoC-3ilnA:5.3 | 5tzoC-3ilnA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jv1 | P22 PROTEIN (Trypanosomabrucei) |
PF02330(MAM33) | 4 | TRP A 79THR A 80THR A 91GLN A 104 | None | 1.34A | 5tzoC-3jv1A:undetectable | 5tzoC-3jv1A:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k4z | GLYCOSIDE HYDROLASEFAMILY 9 (Ruminiclostridiumthermocellum) |
PF02018(CBM_4_9)PF02927(CelD_N) | 4 | TYR A 100THR A 148ARG A 73GLN A 71 | NoneNoneCBI A 294 (-3.2A)CBI A 294 (-3.0A) | 1.36A | 5tzoC-3k4zA:undetectable | 5tzoC-3k4zA:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kk7 | PUTATIVE CELLINVASION PROTEINWITH MAC/PERFORINDOMAIN (Bacteroidesthetaiotaomicron) |
PF01823(MACPF) | 4 | TYR A 556THR A 419ARG A 420GLN A 421 | None | 1.38A | 5tzoC-3kk7A:undetectable | 5tzoC-3kk7A:17.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3lb9 | ENDO-1,4-BETA-XYLANASE (Bacilluscirculans) |
PF00457(Glyco_hydro_11) | 4 | THR A 156THR A 175ARG A 177GLN A 6 | None | 0.86A | 5tzoC-3lb9A:12.5 | 5tzoC-3lb9A:60.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3lb9 | ENDO-1,4-BETA-XYLANASE (Bacilluscirculans) |
PF00457(Glyco_hydro_11) | 5 | TYR A 173THR A 175ARG A 177GLN A 6TRP A 8 | None | 0.54A | 5tzoC-3lb9A:12.5 | 5tzoC-3lb9A:60.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mf9 | ENDO-1,4-BETA-XYLANASE (Thermopolysporaflexuosa) |
PF00457(Glyco_hydro_11) | 4 | THR A 101THR A 120ARG A 122GLN A 136 | None | 1.01A | 5tzoC-3mf9A:27.8 | 5tzoC-3mf9A:56.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mf9 | ENDO-1,4-BETA-XYLANASE (Thermopolysporaflexuosa) |
PF00457(Glyco_hydro_11) | 5 | TYR A 118THR A 120ARG A 122GLN A 136TRP A 138 | None | 0.66A | 5tzoC-3mf9A:27.8 | 5tzoC-3mf9A:56.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qv9 | PYRUVATE KINASE 2 (Trypanosomacruzi) |
PF00224(PK)PF02887(PK_C) | 4 | THR A 424THR A 428ARG A 427GLN A 431 | None | 1.38A | 5tzoC-3qv9A:undetectable | 5tzoC-3qv9A:16.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3saj | GLUTAMATE RECEPTOR 1 (Rattusnorvegicus) |
PF01094(ANF_receptor) | 4 | THR A 347TYR A 346ARG A 327GLN A 336 | NoneNoneNAG A 800 ( 3.1A)NAG A 800 (-3.1A) | 1.22A | 5tzoC-3sajA:undetectable | 5tzoC-3sajA:16.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v4v | INTEGRIN BETA-7 (Homo sapiens) |
PF00362(Integrin_beta) | 4 | THR B 419ARG B 124GLN B 122TRP B 421 | None | 1.37A | 5tzoC-3v4vB:undetectable | 5tzoC-3v4vB:16.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vsv | XYLOSIDASE (Thermoanaerobacteriumsaccharolyticum) |
PF13229(Beta_helix) | 4 | TRP A 82TYR A 105ARG A 91GLN A 93 | None | 1.41A | 5tzoC-3vsvA:undetectable | 5tzoC-3vsvA:14.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vta | CUCUMISIN (Cucumis melo) |
PF00082(Peptidase_S8) | 4 | TRP A 246THR A 141THR A 201ARG A 199 | None | 1.41A | 5tzoC-3vtaA:undetectable | 5tzoC-3vtaA:16.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vz0 | PUTATIVENAD-DEPENDENTALDEHYDEDEHYDROGENASE (Gluconobacteroxydans) |
PF00171(Aldedh) | 4 | THR A 13THR A 6ARG A 16GLN A 163 | None | 1.25A | 5tzoC-3vz0A:undetectable | 5tzoC-3vz0A:17.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3vzm | ENDO-1,4-BETA-XYLANASE (Bacilluscirculans) |
PF00457(Glyco_hydro_11) | 4 | THR A 91THR A 110ARG A 112GLN A 127 | NoneNoneDFX A 201 (-3.9A)DFX A 201 (-4.3A) | 0.81A | 5tzoC-3vzmA:35.1 | 5tzoC-3vzmA:91.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3vzm | ENDO-1,4-BETA-XYLANASE (Bacilluscirculans) |
PF00457(Glyco_hydro_11) | 5 | TYR A 108THR A 110ARG A 112GLN A 127TRP A 129 | NoneNoneDFX A 201 (-3.9A)DFX A 201 (-4.3A)None | 0.38A | 5tzoC-3vzmA:35.1 | 5tzoC-3vzmA:91.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zse | ENDO-1,4-BETA-XYLANASE (Thermobifidafusca) |
PF00457(Glyco_hydro_11) | 4 | THR A 140THR A 159ARG A 161GLN A 175 | NoneNoneFXP A1207 (-4.1A)FXP A1207 (-4.3A) | 0.78A | 5tzoC-3zseA:28.4 | 5tzoC-3zseA:55.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zse | ENDO-1,4-BETA-XYLANASE (Thermobifidafusca) |
PF00457(Glyco_hydro_11) | 5 | TYR A 157THR A 159ARG A 161GLN A 175TRP A 177 | NoneNoneFXP A1207 (-4.1A)FXP A1207 (-4.3A)None | 0.43A | 5tzoC-3zseA:28.4 | 5tzoC-3zseA:55.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4frx | ANAEROBICALLY-INDUCED OUTER MEMBRANEPORIN OPRE (Pseudomonasaeruginosa) |
PF03573(OprD) | 4 | THR A 145THR A 143ARG A 114GLN A 141 | None | 1.29A | 5tzoC-4frxA:undetectable | 5tzoC-4frxA:19.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4hk9 | ENDO-1,4-BETA-XYLANASE 2 (Trichodermareesei) |
PF00457(Glyco_hydro_11) | 6 | THR A 100TYR A 118THR A 120ARG A 122GLN A 136TRP A 138 | NoneNoneNoneXYP A 203 (-3.7A)XYP A 203 (-4.0A)None | 0.91A | 5tzoC-4hk9A:29.1 | 5tzoC-4hk9A:50.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ixl | XYLANASE (Bacillus sp.(in: Bacteria)) |
PF00457(Glyco_hydro_11) | 4 | TYR A 124ARG A 128GLN A 142TRP A 144 | None | 0.81A | 5tzoC-4ixlA:24.5 | 5tzoC-4ixlA:41.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ixl | XYLANASE (Bacillus sp.(in: Bacteria)) |
PF00457(Glyco_hydro_11) | 4 | TYR A 124THR A 126GLN A 142TRP A 144 | None | 0.62A | 5tzoC-4ixlA:24.5 | 5tzoC-4ixlA:41.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k5r | OXYGENASE (Streptomycesargillaceus) |
PF01494(FAD_binding_3) | 4 | THR A 105THR A 60ARG A 59GLN A 310 | None | 1.29A | 5tzoC-4k5rA:undetectable | 5tzoC-4k5rA:16.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l7w | HD DOMAIN-CONTAININGPROTEIN 2 (Homo sapiens) |
PF13023(HD_3) | 4 | TRP A 35TYR A 168THR A 171GLN A 144 | None | 1.41A | 5tzoC-4l7wA:undetectable | 5tzoC-4l7wA:17.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mdp | BETA-GLUCOSIDASE (Humicola grisea) |
PF00232(Glyco_hydro_1) | 4 | THR A 380TYR A 308THR A 309ARG A 351 | NoneGOL A 507 (-4.1A)NoneNone | 1.18A | 5tzoC-4mdpA:undetectable | 5tzoC-4mdpA:18.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n6d | TRAP DICARBOXYLATETRANSPORTER-DCTPSUBUNIT (Desulfovibriosalexigens) |
PF03480(DctP) | 4 | THR A 118THR A 266ARG A 50GLN A 262 | None | 1.36A | 5tzoC-4n6dA:undetectable | 5tzoC-4n6dA:19.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ofd | KIN OF IRRE-LIKEPROTEIN 1 (Mus musculus) |
PF07679(I-set)PF08205(C2-set_2) | 4 | TRP A 57THR A 58TYR A 102ARG A 114 | None | 1.34A | 5tzoC-4ofdA:undetectable | 5tzoC-4ofdA:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pgj | HUMAN HEAVY CHAINDOMAIN ANTIBODY (Homo sapiens) |
PF07686(V-set) | 4 | TRP A 111TYR A 110THR A 100GLN A 104 | None | 1.32A | 5tzoC-4pgjA:undetectable | 5tzoC-4pgjA:23.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pju | COHESIN SUBUNIT SA-2DOUBLE-STRAND-BREAKREPAIR PROTEIN RAD21HOMOLOG (Homo sapiens) |
PF08514(STAG)no annotation | 4 | TRP B 381THR A 626THR A 586GLN A 590 | None | 1.39A | 5tzoC-4pjuB:undetectable | 5tzoC-4pjuB:16.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q4y | COXSACKIEVIRUSCAPSID PROTEIN VP1 (Enterovirus C) |
PF00073(Rhv) | 4 | THR 1 241TYR 1 161ARG 1 245GLN 1 158 | NoneNone CL 15008 (-3.6A)None | 1.28A | 5tzoC-4q4y1:undetectable | 5tzoC-4q4y1:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rep | GAMMA-CAROTENEDESATURASE (Nonlabensdokdonensis) |
PF01593(Amino_oxidase) | 4 | TRP A 309THR A 410ARG A 313TRP A 368 | NoneGOL A 502 ( 4.1A)NoneNone | 1.41A | 5tzoC-4repA:undetectable | 5tzoC-4repA:15.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w65 | GLYCOSYL HYDROLASEFAMILY PROTEIN (Mycolicibacteriumfortuitum) |
PF00722(Glyco_hydro_16) | 4 | THR A 220TYR A 219THR A 203ARG A 140 | THR A 220 ( 0.8A)TYR A 219 ( 1.3A)THR A 203 ( 0.8A)ARG A 140 ( 0.6A) | 1.05A | 5tzoC-4w65A:5.6 | 5tzoC-4w65A:24.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w6y | NANOBODY NBFEDF9 (Lama glama) |
PF07686(V-set) | 4 | THR B 28TYR B 29THR B 53ARG B 54 | None | 1.29A | 5tzoC-4w6yB:undetectable | 5tzoC-4w6yB:24.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zfm | PUTATIVE6-PHOSPHO-BETA-GALACTOBIOSIDASE (Geobacillusstearothermophilus) |
PF00232(Glyco_hydro_1) | 4 | TRP A 15THR A 473ARG A 403GLN A 407 | None | 1.22A | 5tzoC-4zfmA:undetectable | 5tzoC-4zfmA:15.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a7m | BETA-XYLOSIDASE (Trichodermareesei) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 4 | TRP A 280THR A 274GLN A 230TRP A 763 | None ZN A1909 ( 4.4A)NoneNone | 1.31A | 5tzoC-5a7mA:undetectable | 5tzoC-5a7mA:14.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bxp | LACTO-N-BIOSIDASE (Bifidobacteriumbifidum) |
PF00728(Glyco_hydro_20)PF02838(Glyco_hydro_20b)PF14200(RicinB_lectin_2) | 4 | TRP A 610THR A 607THR A 627GLN A 629 | None | 1.17A | 5tzoC-5bxpA:undetectable | 5tzoC-5bxpA:15.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c2v | HYDRAZINE SYNTHASEALPHA SUBUNIT (CandidatusKueneniastuttgartiensis) |
no annotation | 4 | TRP A 458TYR A 554ARG A 490GLN A 557 | None | 1.33A | 5tzoC-5c2vA:undetectable | 5tzoC-5c2vA:12.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c8c | VP1 (Enterovirus A) |
PF00073(Rhv) | 4 | THR A 232TYR A 155ARG A 236GLN A 152 | NoneSTE A 301 ( 4.5A)NoneNone | 1.32A | 5tzoC-5c8cA:undetectable | 5tzoC-5c8cA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cd6 | TPR-DOMAINCONTAINING PROTEIN (Parabacteroidesdistasonis) |
PF17128(DUF5107) | 4 | TRP A 299THR A 560TYR A 561THR A 564 | None | 1.19A | 5tzoC-5cd6A:undetectable | 5tzoC-5cd6A:14.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ej3 | ENDO-1,4-BETA-XYLANASE B (Streptomyceslividans) |
PF00457(Glyco_hydro_11) | 5 | TYR A 117THR A 119ARG A 121GLN A 135TRP A 137 | None | 0.70A | 5tzoC-5ej3A:27.5 | 5tzoC-5ej3A:49.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eyy | CENTROLOBIUMTOMENTOSUM LECTIN (Centrolobiumtomentosum) |
PF00139(Lectin_legB) | 4 | THR A 183TYR A 177THR A 176GLN A 71 | None | 1.02A | 5tzoC-5eyyA:5.0 | 5tzoC-5eyyA:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5foe | GDP-FUCOSE PROTEINO-FUCOSYLTRANSFERASE2,THROMBOSPONDIN-1 (Caenorhabditiselegans;Homo sapiens) |
PF00090(TSP_1)PF10250(O-FucT) | 4 | TRP A 141TYR A 145ARG A1025GLN A1042 | None | 1.34A | 5tzoC-5foeA:undetectable | 5tzoC-5foeA:16.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gxf | ACRYLYL-COAREDUCTASE ACUI (Ruegeriapomeroyi) |
PF00107(ADH_zinc_N) | 4 | THR A 156ARG A 231GLN A 235TRP A 217 | None | 1.22A | 5tzoC-5gxfA:undetectable | 5tzoC-5gxfA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hi8 | ANTENNA PROTEIN (Prochlorococcusphage P-HM1) |
PF06206(CpeT) | 4 | TYR A 41THR A 43ARG A 55GLN A 57 | NoneNoneNoneACT A 202 (-3.8A) | 1.21A | 5tzoC-5hi8A:undetectable | 5tzoC-5hi8A:16.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jbk | BETA-GLUCOSIDASE (Trichodermaharzianum) |
PF00232(Glyco_hydro_1) | 4 | THR A 370TYR A 298THR A 299ARG A 341 | NoneGOL A 501 (-4.1A)NoneNone | 1.23A | 5tzoC-5jbkA:undetectable | 5tzoC-5jbkA:18.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5jrm | ENDO-1,4-BETA-XYLANASE (Fusariumoxysporum) |
PF00457(Glyco_hydro_11) | 4 | TYR A 117ARG A 121GLN A 135TRP A 137 | None | 0.67A | 5tzoC-5jrmA:27.5 | 5tzoC-5jrmA:47.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ldn | HEXON PROTEIN,HEXONCAPSID (HumanmastadenovirusC) |
PF01065(Adeno_hexon)PF03678(Adeno_hexon_C) | 4 | TRP A 677TRP A 730THR A 885ARG A 675 | None | 1.29A | 5tzoC-5ldnA:undetectable | 5tzoC-5ldnA:11.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5njf | METALLOPROTEASE PMBA (Escherichiacoli) |
PF01523(PmbA_TldD) | 4 | THR B 290THR B 325ARG B 316GLN B 326 | None | 1.09A | 5tzoC-5njfB:undetectable | 5tzoC-5njfB:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u38 | LECTIN (Platypodiumelegans) |
PF00139(Lectin_legB) | 4 | THR A 183TYR A 177THR A 176GLN A 71 | None | 1.37A | 5tzoC-5u38A:undetectable | 5tzoC-5u38A:19.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vqj | EXO-BETA-1,4-XYLANASE (unidentified) |
no annotation | 4 | TYR A 129ARG A 133GLN A 147TRP A 149 | None | 1.05A | 5tzoC-5vqjA:23.9 | 5tzoC-5vqjA:17.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wh8 | PUTATIVECARBOHYDRATE-ACTIVEENZYME (unculturedorganism) |
no annotation | 4 | THR A 116TYR A 122THR A 124GLN A 126 | None | 1.38A | 5tzoC-5wh8A:undetectable | 5tzoC-5wh8A:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x1t | PPKA-294 (Serratia sp.FS14) |
no annotation | 4 | TYR A 227THR A 224ARG A 164GLN A 220 | None | 1.32A | 5tzoC-5x1tA:undetectable | 5tzoC-5x1tA:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b3r | PIEZO-TYPEMECHANOSENSITIVE IONCHANNEL COMPONENT 1 (Mus musculus) |
no annotation | 4 | TRP A1730THR A1732THR A1737GLN A1789 | None | 0.91A | 5tzoC-6b3rA:undetectable | 5tzoC-6b3rA:14.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bfu | SPIKE PROTEIN (CoronavirusHKU15) |
no annotation | 4 | THR A 444TYR A 436ARG A 292GLN A 293 | None | 1.33A | 5tzoC-6bfuA:undetectable | 5tzoC-6bfuA:10.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bpz | PIEZO-TYPEMECHANOSENSITIVE IONCHANNEL COMPONENT1,PIEZO-TYPEMECHANOSENSITIVE IONCHANNEL COMPONENT1,MOUSEPIEZO1,PIEZO-TYPEMECHANOSENSITIVE IONCHANNEL COMPONENT1,PIEZO-TYPEMECHANOSENSITIVE IONCHANNEL COMPONENT 1 (Mus musculus) |
no annotation | 4 | TRP A1730THR A1732THR A1737GLN A1789 | None | 1.10A | 5tzoC-6bpzA:undetectable | 5tzoC-6bpzA:15.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eks | SIALIDASE (Vibrio cholerae) |
no annotation | 4 | TRP A 553THR A 554TYR A 394GLN A 423 | None | 1.37A | 5tzoC-6eksA:undetectable | 5tzoC-6eksA:15.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f9n | CLEAVAGE ANDPOLYADENYLATIONSPECIFICITY FACTORSUBUNIT 1 (Homo sapiens) |
no annotation | 4 | TYR A 701THR A 782GLN A 798TRP A 784 | None | 1.20A | 5tzoC-6f9nA:undetectable | 5tzoC-6f9nA:15.96 |