SIMILAR PATTERNS OF AMINO ACIDS FOR 5TZO_B_7V7B202_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1axk GLUXYN-1

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11)
PF00722
(Glyco_hydro_16) 		5 TYR A 264
THR A 266
ARG A 268
GLN A 283
TRP A 285
 None
 0.44A 5tzoB-1axkA:
34.6		 5tzoB-1axkA:
58.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1f5j BETA-1,4-XYLANASE

(Dictyoglomus
thermophilum) 		PF00457
(Glyco_hydro_11) 		4 TRP A 100
THR A 123
ARG A 125
GLN A 139
 None
 1.10A 5tzoB-1f5jA:
25.6		 5tzoB-1f5jA:
42.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1f5j BETA-1,4-XYLANASE

(Dictyoglomus
thermophilum) 		PF00457
(Glyco_hydro_11) 		5 TYR A 121
THR A 123
ARG A 125
GLN A 139
TRP A 141
 None
 0.75A 5tzoB-1f5jA:
25.6		 5tzoB-1f5jA:
42.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gll GLYCEROL KINASE

(Escherichia
coli) 		no annotation 4 THR Y 181
TYR Y 183
ARG Y  83
GLN Y 247
 None
None
GOL  Y 600 (-4.0A)
None
 1.39A 5tzoB-1gllY:
undetectable		 5tzoB-1gllY:
17.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h1a ENDO-1,4-BETA-XYLANA
SE

(Chaetomium
thermophilum) 		PF00457
(Glyco_hydro_11) 		5 THR A 101
TYR A 119
THR A 121
GLN A 137
TRP A 139
 None
 0.83A 5tzoB-1h1aA:
28.8		 5tzoB-1h1aA:
52.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h1a ENDO-1,4-BETA-XYLANA
SE

(Chaetomium
thermophilum) 		PF00457
(Glyco_hydro_11) 		5 TYR A 119
THR A 121
ARG A 123
GLN A 137
TRP A 139
 None
None
GOL  A1196 (-2.8A)
None
None
 1.14A 5tzoB-1h1aA:
28.8		 5tzoB-1h1aA:
52.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hix ENDO-1,4-BETA-XYLANA
SE

(Streptomyces
sp. S38) 		PF00457
(Glyco_hydro_11) 		5 TYR A 117
THR A 119
ARG A 121
GLN A 135
TRP A 137
 None
 0.46A 5tzoB-1hixA:
27.7		 5tzoB-1hixA:
54.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1igo FAMILY 11 XYLANASE

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11) 		4 THR A 109
ARG A 128
GLN A 142
TRP A 144
 None
 1.34A 5tzoB-1igoA:
25.2		 5tzoB-1igoA:
48.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1igo FAMILY 11 XYLANASE

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11) 		5 TYR A 124
THR A 126
ARG A 128
GLN A 142
TRP A 144
 None
 0.64A 5tzoB-1igoA:
25.2		 5tzoB-1igoA:
48.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1imv PIGMENT
EPITHELIUM-DERIVED
FACTOR

(Homo sapiens) 		PF00079
(Serpin) 		4 THR A  67
TYR A 142
THR A 144
ARG A 121
 None
 1.33A 5tzoB-1imvA:
undetectable		 5tzoB-1imvA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		4 THR A 209
THR A 985
ARG A 913
GLN A1047
 None
 0.93A 5tzoB-1k32A:
undetectable		 5tzoB-1k32A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqj A/G-SPECIFIC ADENINE
GLYCOSYLASE

(Escherichia
coli) 		PF00633
(HHH)
PF00730
(HhH-GPD) 		4 TRP A  77
THR A  78
TYR A  51
ARG A  58
 None
None
None
GOL  A 302 (-2.9A)
 1.35A 5tzoB-1kqjA:
undetectable		 5tzoB-1kqjA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ks5 ENDOGLUCANASE A

(Aspergillus
niger) 		PF01670
(Glyco_hydro_12) 		4 TRP A  45
THR A 203
TYR A  61
GLN A  19
 None
 1.11A 5tzoB-1ks5A:
16.5		 5tzoB-1ks5A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nun FIBROBLAST GROWTH
FACTOR-10

(Homo sapiens) 		PF00167
(FGF) 		4 THR A 197
TYR A 161
THR A 163
ARG A 194
 None
 1.40A 5tzoB-1nunA:
undetectable		 5tzoB-1nunA:
18.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1te1 ENDO-1,4-XYLANASE

(Talaromyces
funiculosus) 		PF00457
(Glyco_hydro_11) 		4 TYR B 117
ARG B 121
GLN B 135
TRP B 137
 None
 1.17A 5tzoB-1te1B:
26.8		 5tzoB-1te1B:
45.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tr7 FIMH PROTEIN

(Escherichia
coli) 		no annotation 4 TRP B 103
THR B  57
TYR B  77
ARG B  60
 None
 1.13A 5tzoB-1tr7B:
undetectable		 5tzoB-1tr7B:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ups GLCNAC-ALPHA-1,4-GAL
-RELEASING
ENDO-BETA-GALACTOSID
ASE

(Clostridium
perfringens) 		PF00722
(Glyco_hydro_16) 		4 TRP A 221
THR A 125
TYR A 124
THR A 248
 None
 1.30A 5tzoB-1upsA:
4.0		 5tzoB-1upsA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wi1 CALCIUM-DEPENDENT
ACTIVATOR PROTEIN
FOR SECRETION, CAPS

(Homo sapiens) 		PF00169
(PH) 		4 THR A  87
TYR A  61
THR A  62
GLN A 111
 None
 1.42A 5tzoB-1wi1A:
undetectable		 5tzoB-1wi1A:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yna ENDO-1,4-BETA-XYLANA
SE

(Thermomyces
lanuginosus) 		PF00457
(Glyco_hydro_11) 		4 THR A 120
ARG A 122
GLN A 136
TRP A 138
 None
 0.50A 5tzoB-1ynaA:
27.7		 5tzoB-1ynaA:
44.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlp PETAL DEATH PROTEIN

(Dianthus
caryophyllus) 		PF13714
(PEP_mutase) 		4 THR A 180
TYR A 198
THR A 206
ARG A 228
 None
 1.31A 5tzoB-1zlpA:
undetectable		 5tzoB-1zlpA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0j GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 2

(Homo sapiens) 		PF03360
(Glyco_transf_43) 		4 THR A 189
TYR A 190
THR A 104
GLN A 107
 None
 1.16A 5tzoB-2d0jA:
undetectable		 5tzoB-2d0jA:
19.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dck XYLANASE J

(Bacillus sp.
41M-1) 		PF00457
(Glyco_hydro_11)
PF03422
(CBM_6) 		4 TYR A 124
ARG A 128
GLN A 142
TRP A 144
 None
 0.82A 5tzoB-2dckA:
25.6		 5tzoB-2dckA:
31.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dck XYLANASE J

(Bacillus sp.
41M-1) 		PF00457
(Glyco_hydro_11)
PF03422
(CBM_6) 		4 TYR A 124
THR A 126
ARG A 128
GLN A 142
 None
 1.19A 5tzoB-2dckA:
25.6		 5tzoB-2dckA:
31.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f6b FAMILY 11 XYLANASE

(Bacillus) 		PF00457
(Glyco_hydro_11) 		4 TRP A 104
THR A 127
ARG A 129
GLN A 143
 None
 1.06A 5tzoB-2f6bA:
25.2		 5tzoB-2f6bA:
47.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f6b FAMILY 11 XYLANASE

(Bacillus) 		PF00457
(Glyco_hydro_11) 		5 TYR A 125
THR A 127
ARG A 129
GLN A 143
TRP A 145
 None
 0.42A 5tzoB-2f6bA:
25.2		 5tzoB-2f6bA:
47.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT

(Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 TRP A 471
THR A 231
THR A 807
ARG A 811
 None
 1.42A 5tzoB-2ivfA:
undetectable		 5tzoB-2ivfA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j89 METHIONINE SULFOXIDE
REDUCTASE A

(Populus
trichocarpa) 		PF01625
(PMSR) 		4 THR A 137
TYR A 135
ARG A  92
GLN A  41
 None
 1.20A 5tzoB-2j89A:
undetectable		 5tzoB-2j89A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6x SECRETED CATHEPSIN L
1

(Fasciola
hepatica) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		4 THR A 269
TYR A 275
ARG A 298
GLN A 249
 None
 1.10A 5tzoB-2o6xA:
undetectable		 5tzoB-2o6xA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Desulfovibrio
vulgaris) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 TRP B  41
TYR B  63
THR B  64
ARG B  94
 None
None
None
SH0  A 503 (-2.7A)
 1.38A 5tzoB-2v4jB:
undetectable		 5tzoB-2v4jB:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vcl CYANOBACTERIAL
PHYCOERYTHROBILIN

(Prochlorococcus
phage P-SSM2) 		PF05996
(Fe_bilin_red) 		4 TRP A  47
THR A  62
ARG A  75
TRP A  44
 None
 1.28A 5tzoB-2vclA:
undetectable		 5tzoB-2vclA:
20.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vul GH11 XYLANASE

(Escherichia
coli) 		PF00457
(Glyco_hydro_11) 		4 TYR A 122
ARG A 126
GLN A 140
TRP A 142
 None
 0.49A 5tzoB-2vulA:
28.5		 5tzoB-2vulA:
51.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		4 THR A  99
THR A 275
ARG A 257
GLN A  91
 None
 1.36A 5tzoB-2xh1A:
undetectable		 5tzoB-2xh1A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsj SULFITE REDUCTASE
BETA SUBUNIT

(Desulfomicrobium
norvegicum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
PF12838
(Fer4_7) 		4 TRP B  41
TYR B  63
THR B  64
ARG B  94
 None
None
None
SRM  A 503 (-2.7A)
 1.39A 5tzoB-2xsjB:
undetectable		 5tzoB-2xsjB:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn9 POTASSIUM-TRANSPORTI
NG ATPASE ALPHA
CHAIN 1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF09040
(H-K_ATPase_N)
PF13246
(Cation_ATPase) 		4 TRP A 915
THR A 916
GLN A 924
TRP A 899
 None
 1.42A 5tzoB-2yn9A:
undetectable		 5tzoB-2yn9A:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2u UPF0026 PROTEIN
MJ0257

(Methanocaldococcus
jannaschii) 		PF04055
(Radical_SAM)
PF08608
(Wyosine_form) 		4 TRP A  61
TRP A  89
TYR A 142
THR A  56
 None
 1.33A 5tzoB-2z2uA:
undetectable		 5tzoB-2z2uA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abz BETA-GLUCOSIDASE I

(Kluyveromyces
marxianus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF07691
(PA14)
PF14310
(Fn3-like) 		4 TYR A 482
THR A 512
ARG A 515
GLN A 497
 None
 1.37A 5tzoB-3abzA:
undetectable		 5tzoB-3abzA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahy BETA-GLUCOSIDASE

(Trichoderma
reesei) 		PF00232
(Glyco_hydro_1) 		4 THR A 370
TYR A 298
THR A 299
ARG A 341
 None
TRS  A 500 (-4.1A)
None
None
 1.26A 5tzoB-3ahyA:
undetectable		 5tzoB-3ahyA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aih PROTEIN OS-9

(Homo sapiens) 		PF07915
(PRKCSH) 		4 TRP A 118
THR A 114
TYR A 120
GLN A 129
 MAN  A 301 (-3.8A)
None
None
None
 1.31A 5tzoB-3aihA:
undetectable		 5tzoB-3aihA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvd PLASTOCYANIN

(Phormidium
laminosum) 		PF00127
(Copper-bind) 		4 THR A 102
TYR A  85
THR A  86
GLN A  47
 None
 1.20A 5tzoB-3cvdA:
undetectable		 5tzoB-3cvdA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djl PROTEIN AIDB

(Escherichia
coli) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		4 THR A 298
THR A 378
ARG A 375
TRP A 362
 None
 1.39A 5tzoB-3djlA:
undetectable		 5tzoB-3djlA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dnf 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE

(Aquifex
aeolicus) 		PF02401
(LYTB) 		4 THR A 166
THR A 196
ARG A 226
GLN A 200
 None
 1.33A 5tzoB-3dnfA:
undetectable		 5tzoB-3dnfA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebv CHINITASE A

(Streptomyces
coelicolor) 		PF00704
(Glyco_hydro_18) 		4 THR A   8
TYR A  10
THR A 273
GLN A  21
 None
 1.42A 5tzoB-3ebvA:
undetectable		 5tzoB-3ebvA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 TRP A 624
THR A 610
TYR A 611
THR A 997
 None
 1.33A 5tzoB-3eh1A:
undetectable		 5tzoB-3eh1A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fib FIBRINOGEN GAMMA
CHAIN RESIDUES

(Homo sapiens) 		PF00147
(Fibrinogen_C) 		4 THR A 353
TYR A 377
THR A 374
ARG A 375
 None
 1.34A 5tzoB-3fibA:
undetectable		 5tzoB-3fibA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 TYR A 176
THR A 178
ARG A 278
GLN A 357
 None
None
NO3  A5658 (-4.0A)
NO3  A5658 (-3.1A)
 1.12A 5tzoB-3hrdA:
undetectable		 5tzoB-3hrdA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxg EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Schistosoma
mansoni) 		PF01652
(IF4E) 		4 TRP A  43
ARG A  99
GLN A 187
TRP A  89
 GTA  A   1 (-3.4A)
None
None
GTA  A   1 (-3.6A)
 1.41A 5tzoB-3hxgA:
undetectable		 5tzoB-3hxgA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3o SHORT CHAIN
DEHYDROGENASE

(Bacillus
anthracis) 		PF13561
(adh_short_C2) 		4 THR A 178
TYR A 158
THR A 204
ARG A 205
 NAE  A 311 (-3.9A)
None
None
None
 1.31A 5tzoB-3i3oA:
undetectable		 5tzoB-3i3oA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icv LIPASE B

(Moesziomyces
antarcticus) 		no annotation 4 TRP A  86
THR A 137
THR A 214
ARG A 161
 None
 1.42A 5tzoB-3icvA:
undetectable		 5tzoB-3icvA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if2 AMINOTRANSFERASE

(Psychrobacter
arcticus) 		PF00155
(Aminotran_1_2) 		4 THR A 151
THR A 218
ARG A 415
TRP A 368
 None
 1.20A 5tzoB-3if2A:
undetectable		 5tzoB-3if2A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN

(Bacteroides
thetaiotaomicron) 		PF01823
(MACPF) 		4 TYR A 556
THR A 419
ARG A 420
GLN A 421
 None
 1.36A 5tzoB-3kk7A:
undetectable		 5tzoB-3kk7A:
17.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lb9 ENDO-1,4-BETA-XYLANA
SE

(Bacillus
circulans) 		PF00457
(Glyco_hydro_11) 		4 THR A 156
THR A 175
ARG A 177
GLN A   6
 None
 0.90A 5tzoB-3lb9A:
12.4		 5tzoB-3lb9A:
60.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lb9 ENDO-1,4-BETA-XYLANA
SE

(Bacillus
circulans) 		PF00457
(Glyco_hydro_11) 		5 TYR A 173
THR A 175
ARG A 177
GLN A   6
TRP A   8
 None
 0.50A 5tzoB-3lb9A:
12.4		 5tzoB-3lb9A:
60.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mf9 ENDO-1,4-BETA-XYLANA
SE

(Thermopolyspora
flexuosa) 		PF00457
(Glyco_hydro_11) 		4 THR A 101
THR A 120
ARG A 122
GLN A 136
 None
 1.06A 5tzoB-3mf9A:
27.9		 5tzoB-3mf9A:
56.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mf9 ENDO-1,4-BETA-XYLANA
SE

(Thermopolyspora
flexuosa) 		PF00457
(Glyco_hydro_11) 		5 TYR A 118
THR A 120
ARG A 122
GLN A 136
TRP A 138
 None
 0.67A 5tzoB-3mf9A:
27.9		 5tzoB-3mf9A:
56.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qv9 PYRUVATE KINASE 2

(Trypanosoma
cruzi) 		PF00224
(PK)
PF02887
(PK_C) 		4 THR A 424
THR A 428
ARG A 427
GLN A 431
 None
 1.39A 5tzoB-3qv9A:
undetectable		 5tzoB-3qv9A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3saj GLUTAMATE RECEPTOR 1

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 THR A 347
TYR A 346
ARG A 327
GLN A 336
 None
None
NAG  A 800 ( 3.1A)
NAG  A 800 (-3.1A)
 1.20A 5tzoB-3sajA:
undetectable		 5tzoB-3sajA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vz0 PUTATIVE
NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF00171
(Aldedh) 		4 THR A  13
THR A   6
ARG A  16
GLN A 163
 None
 1.25A 5tzoB-3vz0A:
undetectable		 5tzoB-3vz0A:
17.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vzm ENDO-1,4-BETA-XYLANA
SE

(Bacillus
circulans) 		PF00457
(Glyco_hydro_11) 		5 TYR A 108
THR A 110
ARG A 112
GLN A 127
TRP A 129
 None
None
DFX  A 201 (-3.9A)
DFX  A 201 (-4.3A)
None
 0.25A 5tzoB-3vzmA:
35.0		 5tzoB-3vzmA:
91.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zse ENDO-1,4-BETA-XYLANA
SE

(Thermobifida
fusca) 		PF00457
(Glyco_hydro_11) 		4 THR A 140
THR A 159
ARG A 161
GLN A 175
 None
None
FXP  A1207 (-4.1A)
FXP  A1207 (-4.3A)
 0.81A 5tzoB-3zseA:
28.6		 5tzoB-3zseA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zse ENDO-1,4-BETA-XYLANA
SE

(Thermobifida
fusca) 		PF00457
(Glyco_hydro_11) 		5 TYR A 157
THR A 159
ARG A 161
GLN A 175
TRP A 177
 None
None
FXP  A1207 (-4.1A)
FXP  A1207 (-4.3A)
None
 0.33A 5tzoB-3zseA:
28.6		 5tzoB-3zseA:
55.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvu BETA-MANNOSIDASE

(Trichoderma
harzianum) 		PF00703
(Glyco_hydro_2) 		4 TRP A  87
THR A  88
TYR A  89
THR A  39
 None
 1.37A 5tzoB-4cvuA:
2.7		 5tzoB-4cvuA:
11.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hk9 ENDO-1,4-BETA-XYLANA
SE 2

(Trichoderma
reesei) 		PF00457
(Glyco_hydro_11) 		6 THR A 100
TYR A 118
THR A 120
ARG A 122
GLN A 136
TRP A 138
 None
None
None
XYP  A 203 (-3.7A)
XYP  A 203 (-4.0A)
None
 0.88A 5tzoB-4hk9A:
29.4		 5tzoB-4hk9A:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0w PROTEASE CSPB

(Clostridium
perfringens) 		PF00082
(Peptidase_S8) 		4 THR B 132
TYR B 131
THR B 143
ARG B 144
 None
 1.42A 5tzoB-4i0wB:
undetectable		 5tzoB-4i0wB:
18.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ixl XYLANASE

(Bacillus sp.
(in: Bacteria)) 		PF00457
(Glyco_hydro_11) 		5 TYR A 124
THR A 126
ARG A 128
GLN A 142
TRP A 144
 None
 0.95A 5tzoB-4ixlA:
24.7		 5tzoB-4ixlA:
41.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5r OXYGENASE

(Streptomyces
argillaceus) 		PF01494
(FAD_binding_3) 		4 THR A 105
THR A  60
ARG A  59
GLN A 310
 None
 1.33A 5tzoB-4k5rA:
undetectable		 5tzoB-4k5rA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kws D-MANNONATE
DEHYDRATASE

(Chromohalobacter
salexigens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 THR A  84
ARG A  74
GLN A  70
TRP A  69
 CL  A 503 ( 4.8A)
None
None
None
 1.19A 5tzoB-4kwsA:
undetectable		 5tzoB-4kwsA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7w HD DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF13023
(HD_3) 		4 TRP A  35
TYR A 168
THR A 171
GLN A 144
 None
 1.31A 5tzoB-4l7wA:
undetectable		 5tzoB-4l7wA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lr4 HYPOTHETICAL PROTEIN

([Eubacterium]
rectale) 		no annotation 4 TRP A  98
THR A  99
TYR A 138
ARG A 135
 None
None
GOL  A 404 (-4.2A)
None
 1.10A 5tzoB-4lr4A:
undetectable		 5tzoB-4lr4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdp BETA-GLUCOSIDASE

(Humicola grisea) 		PF00232
(Glyco_hydro_1) 		4 THR A 380
TYR A 308
THR A 309
ARG A 351
 None
GOL  A 507 (-4.1A)
None
None
 1.16A 5tzoB-4mdpA:
undetectable		 5tzoB-4mdpA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofd KIN OF IRRE-LIKE
PROTEIN 1

(Mus musculus) 		PF07679
(I-set)
PF08205
(C2-set_2) 		4 TRP A  57
THR A  58
TYR A 102
ARG A 114
 None
 1.25A 5tzoB-4ofdA:
undetectable		 5tzoB-4ofdA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pgj HUMAN HEAVY CHAIN
DOMAIN ANTIBODY

(Homo sapiens) 		PF07686
(V-set) 		4 TRP A 111
TYR A 110
THR A 100
GLN A 104
 None
 1.28A 5tzoB-4pgjA:
undetectable		 5tzoB-4pgjA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pju COHESIN SUBUNIT SA-2
DOUBLE-STRAND-BREAK
REPAIR PROTEIN RAD21
HOMOLOG

(Homo sapiens) 		PF08514
(STAG)
no annotation 		4 TRP B 381
THR A 626
THR A 586
GLN A 590
 None
 1.33A 5tzoB-4pjuB:
undetectable		 5tzoB-4pjuB:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4y COXSACKIEVIRUS
CAPSID PROTEIN VP1

(Enterovirus C) 		PF00073
(Rhv) 		4 THR 1 241
TYR 1 161
ARG 1 245
GLN 1 158
 None
None
CL  15008 (-3.6A)
None
 1.25A 5tzoB-4q4y1:
undetectable		 5tzoB-4q4y1:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rep GAMMA-CAROTENE
DESATURASE

(Nonlabens
dokdonensis) 		PF01593
(Amino_oxidase) 		4 TRP A 309
THR A 410
ARG A 313
TRP A 368
 None
GOL  A 502 ( 4.1A)
None
None
 1.42A 5tzoB-4repA:
undetectable		 5tzoB-4repA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN

(Mycolicibacterium
fortuitum) 		PF00722
(Glyco_hydro_16) 		4 THR A 220
TYR A 219
THR A 203
ARG A 140
 THR  A 220 ( 0.8A)
TYR  A 219 ( 1.3A)
THR  A 203 ( 0.8A)
ARG  A 140 ( 0.6A)
 1.04A 5tzoB-4w65A:
5.6		 5tzoB-4w65A:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6y NANOBODY NBFEDF9

(Lama glama) 		PF07686
(V-set) 		4 THR B  28
TYR B  29
THR B  53
ARG B  54
 None
 1.20A 5tzoB-4w6yB:
undetectable		 5tzoB-4w6yB:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE

(Geobacillus
stearothermophilus) 		PF00232
(Glyco_hydro_1) 		4 TRP A  15
THR A 473
ARG A 403
GLN A 407
 None
 1.25A 5tzoB-4zfmA:
undetectable		 5tzoB-4zfmA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
ALPHA SUBUNIT

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 4 TRP A 458
TYR A 554
ARG A 490
GLN A 557
 None
 1.35A 5tzoB-5c2vA:
undetectable		 5tzoB-5c2vA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cd6 TPR-DOMAIN
CONTAINING PROTEIN

(Parabacteroides
distasonis) 		PF17128
(DUF5107) 		4 TRP A 299
THR A 560
TYR A 561
THR A 564
 None
 1.13A 5tzoB-5cd6A:
undetectable		 5tzoB-5cd6A:
14.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ej3 ENDO-1,4-BETA-XYLANA
SE B

(Streptomyces
lividans) 		PF00457
(Glyco_hydro_11) 		5 TYR A 117
THR A 119
ARG A 121
GLN A 135
TRP A 137
 None
 0.73A 5tzoB-5ej3A:
27.5		 5tzoB-5ej3A:
49.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyy CENTROLOBIUM
TOMENTOSUM LECTIN

(Centrolobium
tomentosum) 		PF00139
(Lectin_legB) 		4 THR A 183
TYR A 177
THR A 176
GLN A  71
 None
 1.05A 5tzoB-5eyyA:
4.9		 5tzoB-5eyyA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxf ACRYLYL-COA
REDUCTASE ACUI

(Ruegeria
pomeroyi) 		PF00107
(ADH_zinc_N) 		4 THR A 156
ARG A 231
GLN A 235
TRP A 217
 None
 1.31A 5tzoB-5gxfA:
undetectable		 5tzoB-5gxfA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbk BETA-GLUCOSIDASE

(Trichoderma
harzianum) 		PF00232
(Glyco_hydro_1) 		4 THR A 370
TYR A 298
THR A 299
ARG A 341
 None
GOL  A 501 (-4.1A)
None
None
 1.21A 5tzoB-5jbkA:
undetectable		 5tzoB-5jbkA:
18.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jrm ENDO-1,4-BETA-XYLANA
SE

(Fusarium
oxysporum) 		PF00457
(Glyco_hydro_11) 		4 TYR A 117
ARG A 121
GLN A 135
TRP A 137
 None
 0.59A 5tzoB-5jrmA:
27.6		 5tzoB-5jrmA:
47.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9p PERIPLASMIC BINDING
PROTEIN

(Agrobacterium
tumefaciens) 		PF13416
(SBP_bac_8) 		4 THR A 311
TYR A 310
THR A 317
GLN A 240
 None
 1.42A 5tzoB-5l9pA:
undetectable		 5tzoB-5l9pA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldn HEXON PROTEIN,HEXON
CAPSID

(Human
mastadenovirus
C) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		4 TRP A 677
TRP A 730
THR A 885
ARG A 675
 None
 1.26A 5tzoB-5ldnA:
undetectable		 5tzoB-5ldnA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5njf METALLOPROTEASE PMBA

(Escherichia
coli) 		PF01523
(PmbA_TldD) 		4 THR B 290
THR B 325
ARG B 316
GLN B 326
 None
 1.10A 5tzoB-5njfB:
undetectable		 5tzoB-5njfB:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae) 		no annotation 4 THR B  25
TYR B  28
THR B  10
ARG B  11
 None
 1.40A 5tzoB-5swiB:
undetectable		 5tzoB-5swiB:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u38 LECTIN

(Platypodium
elegans) 		PF00139
(Lectin_legB) 		4 THR A 183
TYR A 177
THR A 176
GLN A  71
 None
 1.39A 5tzoB-5u38A:
5.1		 5tzoB-5u38A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 TRP B 450
THR B 436
TYR B 437
THR B 822
 None
ZN  B1101 ( 4.6A)
None
None
 1.27A 5tzoB-5vniB:
undetectable		 5tzoB-5vniB:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqj EXO-BETA-1,4-XYLANAS
E

(unidentified) 		no annotation 4 TYR A 129
ARG A 133
GLN A 147
TRP A 149
 None
 0.94A 5tzoB-5vqjA:
24.0		 5tzoB-5vqjA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME

(uncultured
organism) 		no annotation 4 THR A 116
TYR A 122
THR A 124
GLN A 126
 None
 1.40A 5tzoB-5wh8A:
undetectable		 5tzoB-5wh8A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1t PPKA-294

(Serratia sp.
FS14) 		no annotation 4 TYR A 227
THR A 224
ARG A 164
GLN A 220
 None
 1.35A 5tzoB-5x1tA:
undetectable		 5tzoB-5x1tA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xk2 DIACYLGLYCEROL
LIPASE

(Aspergillus
oryzae) 		no annotation 4 TRP A 121
THR A 168
ARG A 167
GLN A 195
 None
 1.41A 5tzoB-5xk2A:
undetectable		 5tzoB-5xk2A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3r PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 4 TRP A1730
THR A1732
THR A1737
GLN A1789
 None
 0.94A 5tzoB-6b3rA:
undetectable		 5tzoB-6b3rA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfu SPIKE PROTEIN

(Coronavirus
HKU15) 		no annotation 4 THR A 444
TYR A 436
ARG A 292
GLN A 293
 None
 1.36A 5tzoB-6bfuA:
undetectable		 5tzoB-6bfuA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpz PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,MOUSE
PIEZO1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 4 TRP A1730
THR A1732
THR A1737
GLN A1789
 None
 1.08A 5tzoB-6bpzA:
undetectable		 5tzoB-6bpzA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY

(Thermobifida
fusca) 		no annotation 4 TRP A 441
TRP A 465
TYR A 519
ARG A 524
 None
 1.41A 5tzoB-6c66A:
undetectable		 5tzoB-6c66A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eks SIALIDASE

(Vibrio cholerae) 		no annotation 4 TRP A 553
THR A 554
TYR A 394
GLN A 423
 None
 1.40A 5tzoB-6eksA:
4.5		 5tzoB-6eksA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9n CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 1

(Homo sapiens) 		no annotation 4 TYR A 701
THR A 782
GLN A 798
TRP A 784
 None
 1.26A 5tzoB-6f9nA:
undetectable		 5tzoB-6f9nA:
15.96