SIMILAR PATTERNS OF AMINO ACIDS FOR 5TZO_B_7V7B201_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amo NADPH-CYTOCHROME
P450 REDUCTASE

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		3 ARG A 450
PRO A 362
TYR A 323
 None
 0.70A 5tzoB-1amoA:
undetectable		 5tzoB-1amoA:
15.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1axk GLUXYN-1

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11)
PF00722
(Glyco_hydro_16) 		3 ARG A 268
PRO A 272
TYR A 330
 None
 0.58A 5tzoB-1axkA:
34.6		 5tzoB-1axkA:
58.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dhs DEOXYHYPUSINE
SYNTHASE

(Homo sapiens) 		PF01916
(DS) 		3 ARG A  61
PRO A 336
TYR A 340
 None
 0.94A 5tzoB-1dhsA:
undetectable		 5tzoB-1dhsA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6z CHITINASE B

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		3 ARG A  89
PRO A 178
TYR A 208
 None
 1.02A 5tzoB-1e6zA:
undetectable		 5tzoB-1e6zA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1em2 MLN64 PROTEIN

(Homo sapiens) 		PF01852
(START) 		3 ARG A 380
PRO A 373
TYR A 378
 None
 1.01A 5tzoB-1em2A:
undetectable		 5tzoB-1em2A:
21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1f5j BETA-1,4-XYLANASE

(Dictyoglomus
thermophilum) 		PF00457
(Glyco_hydro_11) 		3 ARG A 125
PRO A 129
TYR A 182
 None
 0.78A 5tzoB-1f5jA:
25.6		 5tzoB-1f5jA:
42.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN

(Panulirus
interruptus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 ARG A 107
PRO A  24
TYR A  27
 None
 1.06A 5tzoB-1hcyA:
undetectable		 5tzoB-1hcyA:
15.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hix ENDO-1,4-BETA-XYLANA
SE

(Streptomyces
sp. S38) 		PF00457
(Glyco_hydro_11) 		3 ARG A 121
PRO A 125
TYR A 179
 None
 0.80A 5tzoB-1hixA:
27.7		 5tzoB-1hixA:
54.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i41 CYSTATHIONINE
GAMMA-SYNTHASE

(Nicotiana
tabacum) 		PF01053
(Cys_Met_Meta_PP) 		3 ARG A 423
PRO A 387
TYR A 404
 HEN  A 500 (-3.3A)
HEN  A 500 (-3.8A)
None
 0.93A 5tzoB-1i41A:
undetectable		 5tzoB-1i41A:
19.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1igo FAMILY 11 XYLANASE

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11) 		3 ARG A 128
PRO A 132
TYR A 185
 None
 0.81A 5tzoB-1igoA:
25.2		 5tzoB-1igoA:
48.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH) 		3 ARG A 382
PRO A 438
TYR A 363
 None
 0.96A 5tzoB-1lrtA:
undetectable		 5tzoB-1lrtA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lw7 TRANSCRIPTIONAL
REGULATOR NADR

(Haemophilus
influenzae) 		PF01467
(CTP_transf_like)
PF13521
(AAA_28) 		3 ARG A 110
PRO A 223
TYR A 332
 None
 0.81A 5tzoB-1lw7A:
undetectable		 5tzoB-1lw7A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH)
PF00571
(CBS) 		3 ARG A 382
PRO A 438
TYR A 363
 None
 0.91A 5tzoB-1mewA:
undetectable		 5tzoB-1mewA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		3 ARG A 253
PRO A 402
TYR A 398
 None
 0.90A 5tzoB-1mlzA:
undetectable		 5tzoB-1mlzA:
18.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pvx PROTEIN
(ENDO-1,4-BETA-XYLAN
ASE)

(Byssochlamys
spectabilis) 		PF00457
(Glyco_hydro_11) 		3 ARG A 122
PRO A 126
TYR A 180
 None
 0.88A 5tzoB-1pvxA:
27.1		 5tzoB-1pvxA:
45.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qi9 PROTEIN (VANADIUM
BROMOPEROXIDASE)

(Ascophyllum
nodosum) 		no annotation 3 ARG A 196
PRO A 206
TYR A 155
 None
 1.06A 5tzoB-1qi9A:
undetectable		 5tzoB-1qi9A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r76 PECTATE LYASE

(Niveispirillum
irakense) 		PF09492
(Pec_lyase) 		3 ARG A 162
PRO A  81
TYR A 141
 None
 0.61A 5tzoB-1r76A:
undetectable		 5tzoB-1r76A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sdd COAGULATION FACTOR V

(Bos taurus) 		PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3) 		3 ARG B1778
PRO B1775
TYR B1956
 None
 0.78A 5tzoB-1sddB:
undetectable		 5tzoB-1sddB:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1u CHOLINE
O-ACETYLTRANSFERASE

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		3 ARG A 463
PRO A 444
TYR A 539
 None
 0.75A 5tzoB-1t1uA:
undetectable		 5tzoB-1t1uA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		3 ARG A 337
PRO A 303
TYR A 332
 None
 1.00A 5tzoB-1tf0A:
undetectable		 5tzoB-1tf0A:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tj5 SUCROSE-PHOSPHATASE

(Synechocystis
sp. PCC 6803) 		PF05116
(S6PP) 		3 ARG A  32
PRO A  60
TYR A  36
 None
 1.07A 5tzoB-1tj5A:
undetectable		 5tzoB-1tj5A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up2 CELA1 PROTEIN

(Mycobacterium
tuberculosis) 		PF01341
(Glyco_hydro_6) 		3 ARG A 358
PRO A 322
TYR A 172
 None
None
SO4  A 385 (-4.8A)
 0.94A 5tzoB-1up2A:
undetectable		 5tzoB-1up2A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9l GLUTAMATE
DEHYDROGENASE

(Pyrobaculum
islandicum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		3 ARG A 400
PRO A 324
TYR A 334
 None
 1.09A 5tzoB-1v9lA:
undetectable		 5tzoB-1v9lA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy9 ALPHA-GALACTOSIDASE

(Thermotoga
maritima) 		PF02065
(Melibiase) 		3 ARG A 414
PRO A  67
TYR A 104
 None
 0.94A 5tzoB-1zy9A:
2.7		 5tzoB-1zy9A:
15.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dck XYLANASE J

(Bacillus sp.
41M-1) 		PF00457
(Glyco_hydro_11)
PF03422
(CBM_6) 		3 ARG A 128
PRO A 132
TYR A 185
 None
 0.88A 5tzoB-2dckA:
25.6		 5tzoB-2dckA:
31.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE

(Bacillus sp.
NG-27) 		PF00331
(Glyco_hydro_10) 		3 ARG A 290
PRO A 236
TYR A 298
 None
 1.03A 5tzoB-2f8qA:
undetectable		 5tzoB-2f8qA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		3 ARG A 317
PRO A 315
TYR A  95
 None
 1.03A 5tzoB-2fjaA:
undetectable		 5tzoB-2fjaA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fy2 CHOLINE
O-ACETYLTRANSFERASE

(Homo sapiens) 		PF00755
(Carn_acyltransf) 		3 ARG A 453
PRO A 434
TYR A 529
 None
 0.76A 5tzoB-2fy2A:
undetectable		 5tzoB-2fy2A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT

(Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 ARG A 142
PRO A 680
TYR A 655
 None
None
MD1  A1987 (-4.5A)
 0.97A 5tzoB-2ivfA:
undetectable		 5tzoB-2ivfA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lrn THIOL:DISULFIDE
INTERCHANGE PROTEIN

(Bacteroides sp.
4_3_47FAA) 		PF00578
(AhpC-TSA) 		3 ARG A 128
PRO A 111
TYR A  50
 None
 0.89A 5tzoB-2lrnA:
undetectable		 5tzoB-2lrnA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2no5 (S)-2-HALOACID
DEHALOGENASE IVA

(Burkholderia
cepacia) 		PF13419
(HAD_2) 		3 ARG A 194
PRO A 201
TYR A 204
 None
 0.74A 5tzoB-2no5A:
undetectable		 5tzoB-2no5A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pb7 E3 UBIQUITIN-PROTEIN
LIGASE UHRF1

(Homo sapiens) 		PF02182
(SAD_SRA) 		3 ARG A 582
PRO A 587
TYR A 555
 None
 1.01A 5tzoB-2pb7A:
undetectable		 5tzoB-2pb7A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE

(Escherichia
virus T7) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		3 ARG A 357
PRO A 248
TYR A 385
 None
 0.72A 5tzoB-2pi5A:
undetectable		 5tzoB-2pi5A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uwf ALKALINE ACTIVE
ENDOXYLANASE

(Bacillus
halodurans) 		PF00331
(Glyco_hydro_10) 		3 ARG A 296
PRO A 242
TYR A 304
 None
 0.96A 5tzoB-2uwfA:
undetectable		 5tzoB-2uwfA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7g UROCANATE HYDRATASE

(Pseudomonas
putida) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		3 ARG A 362
PRO A 360
TYR A  52
 ACT  A1558 (-2.9A)
None
ACT  A1558 ( 4.3A)
 1.03A 5tzoB-2v7gA:
undetectable		 5tzoB-2v7gA:
16.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vul GH11 XYLANASE

(Escherichia
coli) 		PF00457
(Glyco_hydro_11) 		3 ARG A 126
PRO A 130
TYR A 183
 None
12P  A1199 ( 4.6A)
None
 0.55A 5tzoB-2vulA:
28.5		 5tzoB-2vulA:
51.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w61 GLYCOLIPID-ANCHORED
SURFACE PROTEIN 2

(Saccharomyces
cerevisiae) 		PF03198
(Glyco_hydro_72)
PF07983
(X8) 		3 ARG A 207
PRO A 210
TYR A 128
 None
 0.96A 5tzoB-2w61A:
undetectable		 5tzoB-2w61A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwx GLCNAC-BINDING
PROTEIN A

(Vibrio cholerae) 		PF03067
(LPMO_10) 		3 ARG A 143
PRO A  77
TYR A 129
 None
 1.01A 5tzoB-2xwxA:
undetectable		 5tzoB-2xwxA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynk WZI

(Escherichia
coli) 		PF14052
(Caps_assemb_Wzi) 		3 ARG A  34
PRO A 177
TYR A 347
 None
 0.85A 5tzoB-2ynkA:
undetectable		 5tzoB-2ynkA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoy RBAM17540

(Bacillus
amyloliquefaciens) 		PF03067
(LPMO_10) 		3 ARG A 147
PRO A  78
TYR A 133
 None
 0.99A 5tzoB-2yoyA:
undetectable		 5tzoB-2yoyA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5c PROTEIN YPL144W
UNCHARACTERIZED
PROTEIN YLR021W

(Saccharomyces
cerevisiae) 		PF10448
(POC3_POC4) 		3 ARG B  43
PRO A  28
TYR A 113
 None
 1.05A 5tzoB-2z5cB:
undetectable		 5tzoB-2z5cB:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akf PUTATIVE SECRETED
ALPHA
L-ARABINOFURANOSIDAS
E II

(Streptomyces
avermitilis) 		PF04616
(Glyco_hydro_43)
PF05270
(AbfB) 		3 ARG A 279
PRO A 288
TYR A 220
 None
 0.88A 5tzoB-3akfA:
undetectable		 5tzoB-3akfA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvh 25-D1.16 LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ARG L  44
PRO L  58
TYR L  85
 None
 1.02A 5tzoB-3cvhL:
undetectable		 5tzoB-3cvhL:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edy TRIPEPTIDYL-PEPTIDAS
E 1

(Homo sapiens) 		PF09286
(Pro-kuma_activ) 		3 ARG A 492
PRO A 563
TYR A  79
 None
None
EDO  A 704 (-4.6A)
 1.04A 5tzoB-3edyA:
undetectable		 5tzoB-3edyA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoj BACTERIOCHLOROPHYLL
A PROTEIN

(Prosthecochloris
aestuarii) 		PF02327
(BChl_A) 		3 ARG A 286
PRO A 134
TYR A 325
 None
 0.96A 5tzoB-3eojA:
undetectable		 5tzoB-3eojA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h04 UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF07859
(Abhydrolase_3) 		3 ARG A 180
PRO A 135
TYR A 221
 None
 1.06A 5tzoB-3h04A:
undetectable		 5tzoB-3h04A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h96 F420-H2 DEPENDENT
REDUCTASE A

(Mycolicibacterium
smegmatis) 		PF04075
(F420H2_quin_red) 		3 ARG A 132
PRO A  74
TYR A 111
 None
 0.94A 5tzoB-3h96A:
undetectable		 5tzoB-3h96A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hid ADENYLOSUCCINATE
SYNTHETASE

(Yersinia pestis) 		PF00709
(Adenylsucc_synt) 		3 ARG A 307
PRO A 280
TYR A 238
 None
 0.97A 5tzoB-3hidA:
undetectable		 5tzoB-3hidA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		3 ARG A 359
PRO A 433
TYR A 539
 None
 1.08A 5tzoB-3hjrA:
undetectable		 5tzoB-3hjrA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1u BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE

(Clostridium
acetobutylicum) 		PF04616
(Glyco_hydro_43) 		3 ARG A 279
PRO A 288
TYR A 220
 None
None
TRS  A 801 (-4.6A)
 1.02A 5tzoB-3k1uA:
undetectable		 5tzoB-3k1uA:
18.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lb9 ENDO-1,4-BETA-XYLANA
SE

(Bacillus
circulans) 		PF00457
(Glyco_hydro_11) 		3 ARG A 177
PRO A 181
TYR A  53
 None
 0.63A 5tzoB-3lb9A:
12.4		 5tzoB-3lb9A:
60.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mf9 ENDO-1,4-BETA-XYLANA
SE

(Thermopolyspora
flexuosa) 		PF00457
(Glyco_hydro_11) 		3 ARG A 122
PRO A 126
TYR A 179
 None
 0.95A 5tzoB-3mf9A:
27.9		 5tzoB-3mf9A:
56.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nom GLUTAMINE
CYCLOTRANSFERASE

(Zymomonas
mobilis) 		PF05096
(Glu_cyclase_2) 		3 ARG A 160
PRO A 199
TYR A 138
 None
 1.09A 5tzoB-3nomA:
undetectable		 5tzoB-3nomA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oft CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		3 ARG A 276
PRO A 321
TYR A 278
 None
 0.96A 5tzoB-3oftA:
undetectable		 5tzoB-3oftA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfs NADPH--CYTOCHROME
P450 REDUCTASE

(Homo sapiens) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		3 ARG A 453
PRO A 365
TYR A 326
 None
 0.77A 5tzoB-3qfsA:
undetectable		 5tzoB-3qfsA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uqz DNA PROCESSING
PROTEIN DPRA

(Streptococcus
pneumoniae) 		PF02481
(DNA_processg_A) 		3 ARG A 208
PRO A 206
TYR A 173
 None
 1.01A 5tzoB-3uqzA:
undetectable		 5tzoB-3uqzA:
18.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vzm ENDO-1,4-BETA-XYLANA
SE

(Bacillus
circulans) 		PF00457
(Glyco_hydro_11) 		3 ARG A 112
PRO A 116
TYR A 174
 DFX  A 201 (-3.9A)
DFX  A 201 (-3.9A)
None
 0.24A 5tzoB-3vzmA:
35.0		 5tzoB-3vzmA:
91.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zse ENDO-1,4-BETA-XYLANA
SE

(Thermobifida
fusca) 		PF00457
(Glyco_hydro_11) 		3 ARG A 161
PRO A 165
TYR A 218
 FXP  A1207 (-4.1A)
FXP  A1207 (-3.7A)
EDO  A1232 (-3.8A)
 0.53A 5tzoB-3zseA:
28.6		 5tzoB-3zseA:
55.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4beg PHOSPHATIDYLETHANOLA
MINE BINDING PROTEIN

(Mycobacterium
tuberculosis) 		PF01161
(PBP) 		3 ARG A 131
PRO A   5
TYR A  67
 None
 0.76A 5tzoB-4begA:
undetectable		 5tzoB-4begA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 2
GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 5

(Saccharomyces
cerevisiae) 		PF04054
(Not1)
PF04153
(NOT2_3_5) 		3 ARG B  51
PRO A1764
TYR C 460
 None
 1.05A 5tzoB-4by6B:
undetectable		 5tzoB-4by6B:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1u HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV

(Yersinia pestis) 		PF00005
(ABC_tran) 		3 ARG C  87
PRO C  80
TYR C  60
 None
 1.01A 5tzoB-4g1uC:
undetectable		 5tzoB-4g1uC:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq2 NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		3 ARG M 581
PRO M 555
TYR M 574
 None
 1.00A 5tzoB-4gq2M:
undetectable		 5tzoB-4gq2M:
10.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hk9 ENDO-1,4-BETA-XYLANA
SE 2

(Trichoderma
reesei) 		PF00457
(Glyco_hydro_11) 		3 ARG A 122
PRO A 126
TYR A 179
 XYP  A 203 (-3.7A)
XYP  A 203 ( 4.0A)
None
 0.36A 5tzoB-4hk9A:
29.4		 5tzoB-4hk9A:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4q BEL-BETA TREFOIL

(Boletus edulis) 		no annotation 3 ARG A  27
PRO A  32
TYR A  37
 GOL  A 201 (-4.0A)
None
GOL  A 201 ( 4.0A)
 1.03A 5tzoB-4i4qA:
undetectable		 5tzoB-4i4qA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4s BEL BETA-TREFOIL

(Boletus edulis) 		no annotation 3 ARG A  27
PRO A  32
TYR A  37
 GOL  A 203 (-3.9A)
None
GOL  A 203 (-3.6A)
 0.97A 5tzoB-4i4sA:
undetectable		 5tzoB-4i4sA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4s BEL BETA-TREFOIL

(Boletus edulis) 		no annotation 3 ARG A 121
PRO A 126
TYR A 131
 GOL  A 202 (-3.8A)
None
GOL  A 202 (-3.6A)
 0.97A 5tzoB-4i4sA:
undetectable		 5tzoB-4i4sA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idj FAB LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ARG L  45
PRO L  59
TYR L  86
 None
 1.06A 5tzoB-4idjL:
undetectable		 5tzoB-4idjL:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Saccharomyces
cerevisiae) 		PF03200
(Glyco_hydro_63)
PF16923
(Glyco_hydro_63N) 		3 ARG A 698
PRO A 684
TYR A 691
 None
 0.96A 5tzoB-4j5tA:
undetectable		 5tzoB-4j5tA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt0 MTRE PROTEIN

(Neisseria
gonorrhoeae) 		PF02321
(OEP) 		3 ARG A 193
PRO A 216
TYR A 413
 None
 0.99A 5tzoB-4mt0A:
undetectable		 5tzoB-4mt0A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ony EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 5

(Brucella
melitensis) 		PF00496
(SBP_bac_5) 		3 ARG A 351
PRO A 395
TYR A 452
 None
 0.76A 5tzoB-4onyA:
undetectable		 5tzoB-4onyA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmz XYLANASE

(Xanthomonas
citri) 		PF00331
(Glyco_hydro_10) 		3 ARG A 311
PRO A 260
TYR A 269
 None
 0.95A 5tzoB-4pmzA:
undetectable		 5tzoB-4pmzA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		3 ARG A 337
PRO A 303
TYR A 332
 None
 1.01A 5tzoB-4po0A:
undetectable		 5tzoB-4po0A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rn3 HAD SUPERFAMILY
HYDROLASE

(Geobacter
sulfurreducens) 		PF13419
(HAD_2) 		3 ARG A 200
PRO A 194
TYR A 191
 None
 1.08A 5tzoB-4rn3A:
undetectable		 5tzoB-4rn3A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvw ZNUD

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ARG A 486
PRO A 488
TYR A 545
 None
 1.08A 5tzoB-4rvwA:
undetectable		 5tzoB-4rvwA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tuw HISTONE RNA
HAIRPIN-BINDING
PROTEIN

(Drosophila
melanogaster) 		PF15247
(SLBP_RNA_bind) 		3 ARG A 229
PRO A 219
TYR A 211
 None
 1.03A 5tzoB-4tuwA:
undetectable		 5tzoB-4tuwA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnz LIGHT CHAIN OF
ANTIBODY VRC06B

(Homo sapiens) 		no annotation 3 ARG L  44
PRO L  58
TYR L  85
 None
 0.99A 5tzoB-4xnzL:
undetectable		 5tzoB-4xnzL:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a11 THIOCYANATE FORMING
PROTEIN

(Thlaspi arvense) 		PF01344
(Kelch_1) 		3 ARG A  94
PRO A 155
TYR A  45
 None
 1.03A 5tzoB-5a11A:
undetectable		 5tzoB-5a11A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus) 		PF01398
(JAB)
PF01399
(PCI)
PF13012
(MitMem_reg) 		3 ARG F 110
PRO F 254
TYR M 139
 None
 0.92A 5tzoB-5a5tF:
undetectable		 5tzoB-5a5tF:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		3 ARG A 193
PRO A  45
TYR A  88
 None
 0.93A 5tzoB-5cjfA:
undetectable		 5tzoB-5cjfA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ecu CELLULASE

(Caldicellulosiruptor
saccharolyticus) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		3 ARG A 367
PRO A 372
TYR A  38
 None
 1.08A 5tzoB-5ecuA:
undetectable		 5tzoB-5ecuA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fav CHOLINE
TRIMETHYLAMINE-LYASE

(Desulfovibrio
alaskensis) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 ARG A 274
PRO A 112
TYR A 106
 None
None
MLI  A 904 (-4.5A)
 1.04A 5tzoB-5favA:
undetectable		 5tzoB-5favA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fm5 OBSCURIN-LIKE-1

(Homo sapiens) 		PF07679
(I-set) 		3 ARG O 296
PRO O 275
TYR O 268
 None
 1.00A 5tzoB-5fm5O:
undetectable		 5tzoB-5fm5O:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftz CHITIN BINDING
PROTEIN

(Streptomyces
lividans) 		PF03067
(LPMO_10) 		3 ARG A 142
PRO A  72
TYR A 128
 None
 0.94A 5tzoB-5ftzA:
undetectable		 5tzoB-5ftzA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		3 ARG A 337
PRO A 303
TYR A 332
 None
 1.00A 5tzoB-5ghkA:
undetectable		 5tzoB-5ghkA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpl PUTATIVE NUCLEOSOME
ASSEMBLY PROTEIN
C36B7.08C

(Schizosaccharomyces
pombe) 		PF00956
(NAP) 		3 ARG A  39
PRO A 191
TYR A  80
 None
 0.99A 5tzoB-5gplA:
undetectable		 5tzoB-5gplA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs1 LIGHT CHAIN

(Homo sapiens) 		PF07686
(V-set) 		3 ARG A  46
PRO A  60
TYR A  87
 None
 1.09A 5tzoB-5gs1A:
undetectable		 5tzoB-5gs1A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwe CYTOCHROME P450

(Corynebacterium
glutamicum) 		PF00067
(p450) 		3 ARG A 444
PRO A 446
TYR A 335
 SO4  A 503 (-3.1A)
None
SO4  A 503 (-4.0A)
 0.99A 5tzoB-5gweA:
undetectable		 5tzoB-5gweA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5icq METHYLOCYSTIS PARVUS
OBBP MBNE

(Methylocystis
parvus) 		PF00496
(SBP_bac_5) 		3 ARG A 362
PRO A 406
TYR A 462
 None
 0.84A 5tzoB-5icqA:
undetectable		 5tzoB-5icqA:
15.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jrm ENDO-1,4-BETA-XYLANA
SE

(Fusarium
oxysporum) 		PF00457
(Glyco_hydro_11) 		3 ARG A 121
PRO A 125
TYR A 178
 None
GOL  A 201 (-4.1A)
None
 0.77A 5tzoB-5jrmA:
27.6		 5tzoB-5jrmA:
47.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kxj L-ASPARTATE OXIDASE

(Salmonella
enterica) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		3 ARG A 444
PRO A 217
TYR A 213
 GOL  A 603 (-3.2A)
GOL  A 603 ( 4.5A)
None
 1.03A 5tzoB-5kxjA:
undetectable		 5tzoB-5kxjA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqs BETA-L-ARABINOBIOSID
ASE

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2) 		3 ARG A  59
PRO A 456
TYR A 361
 None
 0.80A 5tzoB-5mqsA:
6.0		 5tzoB-5mqsA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ori ALBUMIN

(Capra hircus) 		no annotation 3 ARG A 144
PRO A 113
TYR A 139
 None
 1.07A 5tzoB-5oriA:
undetectable		 5tzoB-5oriA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ori ALBUMIN

(Capra hircus) 		no annotation 3 ARG A 336
PRO A 302
TYR A 331
 None
 1.03A 5tzoB-5oriA:
undetectable		 5tzoB-5oriA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uy3 ANTIBODY PGT144 FAB
LIGHT CHAIN

(Homo sapiens) 		no annotation 3 ARG L  45
PRO L  59
TYR L  86
 None
 1.07A 5tzoB-5uy3L:
undetectable		 5tzoB-5uy3L:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjn CYTOCHROME P450

(Corynebacterium
glutamicum) 		PF00067
(p450) 		3 ARG A 417
PRO A 419
TYR A 308
 None
 1.06A 5tzoB-5xjnA:
undetectable		 5tzoB-5xjnA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 ARG A 470
PRO A 465
TYR B 833
 None
 1.08A 5tzoB-5xogA:
undetectable		 5tzoB-5xogA:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xon PROTEIN THAT FORMS A
COMPLEX WITH SPT4P
TRANSCRIPTION
ELONGATION FACTOR
SPT4

(Komagataella
phaffii) 		PF00467
(KOW)
PF03439
(Spt5-NGN)
PF06093
(Spt4) 		3 ARG V  73
PRO W 213
TYR V 104
 None
 1.01A 5tzoB-5xonV:
undetectable		 5tzoB-5xonV:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtb NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
12
NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL

(Homo sapiens) 		PF00384
(Molybdopterin)
PF05071
(NDUFA12)
PF09326
(NADH_dhqG_C)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4) 		3 ARG M 308
PRO M 578
TYR N 144
 None
 0.89A 5tzoB-5xtbM:
undetectable		 5tzoB-5xtbM:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE

(Pseudomonas
nitroreducens) 		no annotation 3 ARG A 439
PRO A 453
TYR A 463
 None
 1.03A 5tzoB-6em0A:
undetectable		 5tzoB-6em0A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gii CYTOCHROME P450

(Tepidiphilus
thermophilus) 		no annotation 3 ARG A 459
PRO A 461
TYR A 351
 None
 0.79A 5tzoB-6giiA:
undetectable		 5tzoB-6giiA:
16.67