SIMILAR PATTERNS OF AMINO ACIDS FOR 5TZO_B_7V7B201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1axk GLUXYN-1

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11)
PF00722
(Glyco_hydro_16) 		6 VAL A 193
TRP A 227
TYR A 236
TRP A 285
TYR A 322
GLY A 329
 None
 0.61A 5tzoB-1axkA:
34.6		 5tzoB-1axkA:
58.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl6 ATPASE

(Escherichia
coli) 		PF10412
(TrwB_AAD_bind) 		5 LEU A 413
SER A 409
VAL A 411
ALA A 486
GLY A 478
 None
 0.94A 5tzoB-1gl6A:
undetectable		 5tzoB-1gl6A:
18.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h1a ENDO-1,4-BETA-XYLANA
SE

(Chaetomium
thermophilum) 		PF00457
(Glyco_hydro_11) 		6 VAL A  47
TRP A  80
TYR A  89
TRP A 139
TYR A 172
GLY A 179
 None
 0.69A 5tzoB-1h1aA:
28.8		 5tzoB-1h1aA:
52.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h39 SQUALENE--HOPENE
CYCLASE

(Alicyclobacillus
acidocaldarius) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		5 LEU A 475
VAL A 500
TRP A 558
ALA A 499
GLY A 498
 None
 1.20A 5tzoB-1h39A:
undetectable		 5tzoB-1h39A:
17.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hix ENDO-1,4-BETA-XYLANA
SE

(Streptomyces
sp. S38) 		PF00457
(Glyco_hydro_11) 		6 VAL A  48
TRP A  80
TYR A  89
TRP A 137
TYR A 171
GLY A 178
 None
 0.54A 5tzoB-1hixA:
27.7		 5tzoB-1hixA:
54.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzv NITRITE REDUCTASE

(Pseudomonas
aeruginosa) 		PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3) 		5 LEU A 194
VAL A 227
ALA A 251
ALA A 242
GLY A 243
 None
 1.05A 5tzoB-1hzvA:
0.0		 5tzoB-1hzvA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE

(Cucurbita
moschata) 		PF01553
(Acyltransferase)
PF14829
(GPAT_N) 		5 LEU A 213
SER A 191
VAL A 189
TRP A 228
GLY A 168
 None
 1.16A 5tzoB-1iuqA:
undetectable		 5tzoB-1iuqA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhk IG GAMMA-1-CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU H  45
VAL H  37
TRP H  50
TRP H  95
GLY H  49
 None
 1.19A 5tzoB-1jhkH:
undetectable		 5tzoB-1jhkH:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE

(Pyrococcus
horikoshii) 		PF06026
(Rib_5-P_isom_A) 		5 LEU A 120
VAL A  84
ALA A 114
ALA A  83
GLY A  25
 None
 1.14A 5tzoB-1lk5A:
0.0		 5tzoB-1lk5A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p2z HEXON PROTEIN

(Human
mastadenovirus
C) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		5 LEU A 931
PHE A 695
VAL A 933
ALA A 665
TRP A 687
 None
 1.01A 5tzoB-1p2zA:
undetectable		 5tzoB-1p2zA:
10.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pvx PROTEIN
(ENDO-1,4-BETA-XYLAN
ASE)

(Byssochlamys
spectabilis) 		PF00457
(Glyco_hydro_11) 		5 VAL A  46
TRP A  79
TYR A  88
TRP A 138
TYR A 172
 None
 0.71A 5tzoB-1pvxA:
27.1		 5tzoB-1pvxA:
45.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry2 ACETYL-COENZYME A
SYNTHETASE 1

(Saccharomyces
cerevisiae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 LEU A 417
VAL A 412
TYR A 454
ALA A 360
GLY A 361
 None
 1.14A 5tzoB-1ry2A:
undetectable		 5tzoB-1ry2A:
15.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1te1 ENDO-1,4-XYLANASE

(Talaromyces
funiculosus) 		PF00457
(Glyco_hydro_11) 		5 TRP B  78
TYR B  87
TRP B 137
TYR B 170
GLY B 177
 None
 0.72A 5tzoB-1te1B:
26.8		 5tzoB-1te1B:
45.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkr POLYPOROPEPSIN

(Irpex lacteus) 		PF00026
(Asp) 		5 LEU A 142
SER A   4
ALA A   1
ALA A   2
GLY A   3
 None
 1.03A 5tzoB-1wkrA:
undetectable		 5tzoB-1wkrA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9j PROBABLE BUTYRATE
KINASE 2

(Thermotoga
maritima) 		PF00871
(Acetate_kinase) 		5 SER A 106
ALA A 113
TYR A 355
ALA A 110
GLY A 109
 None
 1.10A 5tzoB-1x9jA:
undetectable		 5tzoB-1x9jA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y80 PREDICTED COBALAMIN
BINDING PROTEIN

(Moorella
thermoacetica) 		PF02310
(B12-binding) 		5 LEU A 163
VAL A 174
ALA A 186
ALA A 191
GLY A 193
 None
 1.17A 5tzoB-1y80A:
undetectable		 5tzoB-1y80A:
21.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yna ENDO-1,4-BETA-XYLANA
SE

(Thermomyces
lanuginosus) 		PF00457
(Glyco_hydro_11) 		5 VAL A  46
TRP A  79
TYR A  88
TRP A 138
TYR A 172
 None
 0.58A 5tzoB-1ynaA:
27.7		 5tzoB-1ynaA:
44.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be3 GTP
PYROPHOSPHOKINASE

(Streptococcus
pneumoniae) 		PF04607
(RelA_SpoT) 		5 LEU A   9
VAL A  46
ALA A 138
ALA A  74
GLY A  75
 None
 1.13A 5tzoB-2be3A:
undetectable		 5tzoB-2be3A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6k TRANSKETOLASE

(Thermus
thermophilus) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		6 LEU A 536
SER A 551
VAL A 553
ALA A 601
TYR A 534
ALA A 548
 None
 1.37A 5tzoB-2e6kA:
undetectable		 5tzoB-2e6kA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqx MEMBRANE LIPOPROTEIN
TMPC

(Treponema
pallidum) 		PF02608
(Bmp) 		5 LEU A  80
SER A  45
ALA A 262
ALA A 266
GLY A  43
 None
 1.18A 5tzoB-2fqxA:
undetectable		 5tzoB-2fqxA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus sp.
GL1) 		PF07470
(Glyco_hydro_88) 		5 ALA A 281
TRP A 372
TYR A 356
ALA A 224
GLY A 222
 None
 1.20A 5tzoB-2fv0A:
undetectable		 5tzoB-2fv0A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF01571
(GCV_T)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4) 		5 LEU A 167
SER A 430
ALA A 248
ALA A 139
GLY A 432
 None
None
NAD  A 999 (-4.8A)
NAD  A 999 (-3.2A)
None
 1.14A 5tzoB-2gahA:
undetectable		 5tzoB-2gahA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0k OXIDOREDUCTASE

(Brevibacterium
sterolicum) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		5 LEU A 289
SER A 307
ALA A 204
ALA A 310
GLY A 309
 None
 1.16A 5tzoB-2i0kA:
undetectable		 5tzoB-2i0kA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran) 		5 ALA A1907
TRP A1757
TYR A1754
ALA A1908
GLY A1909
 None
 1.19A 5tzoB-2ix8A:
undetectable		 5tzoB-2ix8A:
11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Saccharomyces
cerevisiae) 		PF00156
(Pribosyltran) 		5 LEU A 107
PHE A 154
VAL A 109
ALA A  63
ALA A  35
 None
 1.14A 5tzoB-2jkyA:
undetectable		 5tzoB-2jkyA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jty TYPE-1 FIMBRIAL
PROTEIN, A CHAIN

(Escherichia
coli) 		PF00419
(Fimbrial) 		5 LEU A  88
VAL A  99
ALA A  47
ALA A 139
GLY A 141
 None
 1.20A 5tzoB-2jtyA:
undetectable		 5tzoB-2jtyA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jxm CYTOCHROME F

(Prochlorothrix
hollandica) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		5 LEU B  83
VAL B 104
ALA B  73
ALA B 117
GLY B 118
 None
None
None
None
HEC  B 250 ( 4.3A)
 1.03A 5tzoB-2jxmB:
undetectable		 5tzoB-2jxmB:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ka9 DISKS LARGE HOMOLOG
4

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 LEU A  86
SER A  82
VAL A  84
ALA A  80
GLY A  81
 None
 1.17A 5tzoB-2ka9A:
undetectable		 5tzoB-2ka9A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obe HEXON

(Human
mastadenovirus
E) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		5 LEU A 896
PHE A 660
VAL A 898
ALA A 630
TRP A 652
 None
 0.97A 5tzoB-2obeA:
undetectable		 5tzoB-2obeA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7a BACTERIAL HEME
BINDING PROTEIN

(Shigella
dysenteriae) 		PF01497
(Peripla_BP_2) 		5 LEU A 147
SER A 269
VAL A 267
ALA A 192
ALA A 190
 None
 1.15A 5tzoB-2r7aA:
undetectable		 5tzoB-2r7aA:
19.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vul GH11 XYLANASE

(Escherichia
coli) 		PF00457
(Glyco_hydro_11) 		6 VAL A  50
TRP A  82
TYR A  91
TRP A 142
TYR A 175
GLY A 182
 None
12P  A1199 ( 4.7A)
None
None
12P  A1199 (-4.2A)
None
 0.76A 5tzoB-2vulA:
28.5		 5tzoB-2vulA:
51.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9m POLYMERASE X

(Deinococcus
radiodurans) 		PF14520
(HHH_5)
PF14716
(HHH_8) 		5 LEU A 294
PHE A 291
VAL A 290
ALA A 242
GLY A 244
 None
 1.16A 5tzoB-2w9mA:
undetectable		 5tzoB-2w9mA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xec PUTATIVE MALEATE
ISOMERASE

(Nocardia
farcinica) 		no annotation 5 LEU A 122
SER A 224
ALA A 217
ALA A 220
GLY A 221
 None
 1.16A 5tzoB-2xecA:
undetectable		 5tzoB-2xecA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfs ORF12

(Streptomyces
clavuligerus) 		PF13354
(Beta-lactamase2) 		5 LEU A 340
VAL A 336
ALA A 257
ALA A 258
GLY A 259
 None
 1.18A 5tzoB-2xfsA:
undetectable		 5tzoB-2xfsA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aka PUTATIVE CALCIUM
BINDING PROTEIN

(Streptomyces
coelicolor) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		5 LEU A  60
SER A  28
ALA A  36
ALA A  33
GLY A  32
 None
 1.15A 5tzoB-3akaA:
undetectable		 5tzoB-3akaA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 SER A 185
VAL A 138
ALA A1009
ALA A 137
GLY A 136
 None
 1.19A 5tzoB-3cmtA:
undetectable		 5tzoB-3cmtA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 SER A1185
VAL A1138
ALA A2009
ALA A1137
GLY A1136
 None
 1.21A 5tzoB-3cmtA:
undetectable		 5tzoB-3cmtA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 SER A2185
VAL A2138
ALA A3009
ALA A2137
GLY A2136
 None
 1.21A 5tzoB-3cmtA:
undetectable		 5tzoB-3cmtA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 SER A3185
VAL A3138
ALA A4009
ALA A3137
GLY A3136
 None
 1.19A 5tzoB-3cmtA:
undetectable		 5tzoB-3cmtA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 SER A4185
VAL A4138
ALA A5009
ALA A4137
GLY A4136
 None
 1.20A 5tzoB-3cmuA:
undetectable		 5tzoB-3cmuA:
5.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gh8 IODOTYROSINE
DEHALOGENASE 1

(Mus musculus) 		PF00881
(Nitroreductase) 		5 LEU A 256
SER A 124
VAL A 213
ALA A 119
ALA A 216
 None
 1.20A 5tzoB-3gh8A:
undetectable		 5tzoB-3gh8A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER

(Rhodospirillum
rubrum) 		PF13458
(Peripla_BP_6) 		5 LEU A 326
VAL A 322
ALA A 155
ALA A 321
GLY A 318
 None
 1.21A 5tzoB-3hutA:
undetectable		 5tzoB-3hutA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6y ESTERASE APC40077

(Oleispira
antarctica) 		PF00756
(Esterase) 		5 LEU A 249
SER A 148
ALA A 145
ALA A 170
GLY A 151
 None
CL  A 280 (-3.0A)
None
None
None
 1.16A 5tzoB-3i6yA:
undetectable		 5tzoB-3i6yA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j97 VESICLE-FUSING
ATPASE

(Cricetulus
griseus) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2) 		5 LEU A  16
SER A  25
VAL A  23
ALA A   9
ALA A  61
 None
 1.16A 5tzoB-3j97A:
undetectable		 5tzoB-3j97A:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 SER A 207
ALA A 213
TYR A 311
ALA A 210
GLY A 209
 None
None
None
SO4  A 337 (-3.3A)
SO4  A 337 (-4.0A)
 1.15A 5tzoB-3k2bA:
undetectable		 5tzoB-3k2bA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9d PUTATIVE GTP
PYROPHOSPHOKINASE

(Streptococcus
mutans) 		PF04607
(RelA_SpoT) 		5 LEU A   7
VAL A  44
ALA A 136
ALA A  72
GLY A  73
 None
 1.18A 5tzoB-3l9dA:
undetectable		 5tzoB-3l9dA:
20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lb9 ENDO-1,4-BETA-XYLANA
SE

(Bacillus
circulans) 		PF00457
(Glyco_hydro_11) 		6 VAL A 102
TRP A 136
TYR A 145
TRP A   8
TYR A  45
GLY A  52
 None
 0.58A 5tzoB-3lb9A:
12.4		 5tzoB-3lb9A:
60.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lps TOPOISOMERASE IV
SUBUNIT B

(Xanthomonas
oryzae) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		5 LEU A 267
PHE A 361
SER A 309
VAL A 362
ALA A 234
 None
 1.17A 5tzoB-3lpsA:
undetectable		 5tzoB-3lpsA:
17.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mf9 ENDO-1,4-BETA-XYLANA
SE

(Thermopolyspora
flexuosa) 		PF00457
(Glyco_hydro_11) 		5 VAL A  49
TRP A  81
TRP A 138
TYR A 171
GLY A 178
 None
 0.66A 5tzoB-3mf9A:
27.9		 5tzoB-3mf9A:
56.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndn O-SUCCINYLHOMOSERINE
SULFHYDRYLASE

(Mycobacterium
tuberculosis) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A 105
VAL A 101
ALA A 231
ALA A 100
GLY A  97
 None
None
None
None
LLP  A 219 ( 3.2A)
 1.17A 5tzoB-3ndnA:
undetectable		 5tzoB-3ndnA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3olo TWO-COMPONENT SENSOR
HISTIDINE KINASE

(Nostoc sp. PCC
7120) 		PF00989
(PAS) 		5 LEU A  26
SER A  95
VAL A 109
ALA A  22
TYR A  82
 None
 1.21A 5tzoB-3oloA:
undetectable		 5tzoB-3oloA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otn SUSD SUPERFAMILY
PROTEIN

(Parabacteroides
distasonis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 SER A 203
ALA A 216
TYR A  51
ALA A 213
GLY A 212
 None
None
EDO  A 634 ( 4.1A)
None
None
 1.02A 5tzoB-3otnA:
undetectable		 5tzoB-3otnA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbw ANHYDRO-N-ACETYLMURA
MIC ACID KINASE

(Pseudomonas
aeruginosa) 		PF03702
(AnmK) 		5 LEU A 219
VAL A 214
ALA A 209
ALA A 263
GLY A 212
 None
 1.07A 5tzoB-3qbwA:
undetectable		 5tzoB-3qbwA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rl7 DISKS LARGE HOMOLOG
1

(Homo sapiens) 		no annotation 5 LEU B 305
SER B 301
VAL B 303
ALA B 299
GLY B 300
 None
 1.18A 5tzoB-3rl7B:
undetectable		 5tzoB-3rl7B:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tua BURKHOLDERIA LETHAL
FACTOR 1 (BLF1)

(Burkholderia
pseudomallei) 		no annotation 5 LEU A  64
VAL A 104
ALA A 138
ALA A  98
GLY A  99
 None
 0.97A 5tzoB-3tuaA:
undetectable		 5tzoB-3tuaA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ui2 SIGNAL RECOGNITION
PARTICLE 43 KDA
PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF12796
(Ank_2) 		5 LEU A 179
VAL A 167
ALA A 201
ALA A 168
GLY A 169
 None
 1.21A 5tzoB-3ui2A:
undetectable		 5tzoB-3ui2A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2i PEPTIDYL-TRNA
HYDROLASE

(Burkholderia
thailandensis) 		PF01195
(Pept_tRNA_hydro) 		5 LEU A 131
VAL A 102
ALA A 172
ALA A 173
GLY A 100
 None
 1.12A 5tzoB-3v2iA:
undetectable		 5tzoB-3v2iA:
21.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vzm ENDO-1,4-BETA-XYLANA
SE

(Bacillus
circulans) 		PF00457
(Glyco_hydro_11) 		6 VAL A  37
TRP A  71
TYR A  80
TRP A 129
TYR A 166
GLY A 173
 XYP  A 202 (-4.9A)
XYP  A 202 ( 4.9A)
None
None
XYP  A 202 (-4.7A)
None
 0.58A 5tzoB-3vzmA:
35.0		 5tzoB-3vzmA:
91.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfa ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		5 LEU A 491
VAL A 249
TRP A 288
ALA A 246
ALA A 247
 None
 1.14A 5tzoB-3wfaA:
undetectable		 5tzoB-3wfaA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyh LYSOZYME G

(Struthio
camelus) 		PF01464
(SLT) 		5 LEU A 113
SER A  71
ALA A  64
ALA A  67
GLY A  68
 None
 1.12A 5tzoB-3wyhA:
undetectable		 5tzoB-3wyhA:
21.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zse ENDO-1,4-BETA-XYLANA
SE

(Thermobifida
fusca) 		PF00457
(Glyco_hydro_11) 		6 VAL A  88
TRP A 120
TYR A 129
TRP A 177
TYR A 210
GLY A 217
 FXP  A1207 (-4.7A)
FXP  A1207 (-4.6A)
None
None
FXP  A1207 (-4.7A)
None
 0.79A 5tzoB-3zseA:
28.6		 5tzoB-3zseA:
55.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b45 CELL DIVISION
PROTEIN FTSZ

(Haloferax
volcanii) 		PF00091
(Tubulin) 		5 LEU A   5
VAL A  31
ALA A 195
ALA A  30
GLY A  29
 None
 1.18A 5tzoB-4b45A:
undetectable		 5tzoB-4b45A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgu MALATE DEHYDROGENASE

(Haloferax
volcanii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A  30
VAL A   6
ALA A  10
ALA A   9
GLY A   8
 None
 1.21A 5tzoB-4bguA:
undetectable		 5tzoB-4bguA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dio NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1

(Sinorhizobium
meliloti) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 LEU A 317
VAL A 347
ALA A 355
ALA A 348
GLY A 349
 None
 1.15A 5tzoB-4dioA:
undetectable		 5tzoB-4dioA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f48 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Xanthomonas
campestris) 		PF00563
(EAL) 		5 LEU A  31
PHE A 227
VAL A 235
ALA A 241
GLY A 237
 None
 1.07A 5tzoB-4f48A:
undetectable		 5tzoB-4f48A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU

(Yersinia pestis) 		PF01032
(FecCD) 		6 LEU A 200
SER A 118
ALA A  96
TRP A 181
ALA A 123
GLY A 122
 None
 1.19A 5tzoB-4g1uA:
undetectable		 5tzoB-4g1uA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbz PUTATIVE
PHOSPHOHISTIDINE
PHOSPHATASE, SIXA

(Nakamurella
multipartita) 		PF00300
(His_Phos_1) 		5 SER A  29
ALA A  26
TYR A  91
ALA A  27
GLY A  28
 ACY  A 205 (-4.6A)
None
None
None
None
 1.02A 5tzoB-4hbzA:
undetectable		 5tzoB-4hbzA:
22.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hk9 ENDO-1,4-BETA-XYLANA
SE 2

(Trichoderma
reesei) 		PF00457
(Glyco_hydro_11) 		6 VAL A  46
TRP A  79
TYR A  88
TRP A 138
TYR A 171
GLY A 178
 XYP  A 202 (-4.9A)
XYP  A 202 (-4.7A)
None
None
XYP  A 202 (-4.7A)
None
 0.71A 5tzoB-4hk9A:
29.4		 5tzoB-4hk9A:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksi LEUCINE
AMINOPEPTIDASE 1,
CHLOROPLASTIC

(Solanum
lycopersicum) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 LEU A 230
VAL A 208
ALA A 172
ALA A 171
GLY A 211
 None
 1.14A 5tzoB-4ksiA:
undetectable		 5tzoB-4ksiA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc9 GLUCOKINASE
REGULATORY PROTEIN

(Rattus
norvegicus) 		no annotation 5 LEU A 245
VAL A  86
ALA A 277
ALA A  87
GLY A  88
 None
 1.20A 5tzoB-4lc9A:
undetectable		 5tzoB-4lc9A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nuh ICE-BINDING PROTEIN

(Leucosporidium) 		PF11999
(DUF3494) 		5 LEU A 184
SER A 160
VAL A 182
ALA A  16
GLY A 199
 None
 1.19A 5tzoB-4nuhA:
undetectable		 5tzoB-4nuhA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oju HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN

(Pseudoflavonifractor
capillosus) 		PF13306
(LRR_5) 		5 LEU A 118
SER A 114
VAL A 116
ALA A  61
GLY A  92
 None
 1.17A 5tzoB-4ojuA:
undetectable		 5tzoB-4ojuA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s2t PROTEIN APP-1

(Caenorhabditis
elegans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		5 LEU P 287
VAL P 285
ALA P 231
TRP P 268
ALA P 198
 None
 0.75A 5tzoB-4s2tP:
undetectable		 5tzoB-4s2tP:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w91 AMINOTRANSFERASE

(Brucella suis) 		PF00266
(Aminotran_5) 		5 LEU A  88
SER A  80
VAL A  84
ALA A 297
GLY A 295
 None
 1.19A 5tzoB-4w91A:
undetectable		 5tzoB-4w91A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjf D-AMINO-ACID OXIDASE

(Sus scrofa) 		PF01266
(DAO) 		5 PHE B 213
ALA B  48
TYR B 224
ALA B  49
GLY B  50
 None
FAD  B 401 (-3.6A)
98B  B 404 (-3.3A)
FAD  B 401 (-3.2A)
FAD  B 401 (-3.9A)
 1.15A 5tzoB-4yjfB:
undetectable		 5tzoB-4yjfB:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0h GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
GAPC1, CYTOSOLIC

(Arabidopsis
thaliana) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 SER O 207
ALA O 213
TYR O 311
ALA O 210
GLY O 209
 None
None
None
SO4  O 403 ( 3.8A)
SO4  O 403 (-3.9A)
 1.07A 5tzoB-4z0hO:
undetectable		 5tzoB-4z0hO:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3j PUTATIVE
QUINONE-OXIDOREDUCTA
SE HOMOLOG,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		5 LEU A 284
VAL A  94
ALA A  42
ALA A  74
GLY A  75
 None
 0.79A 5tzoB-5a3jA:
undetectable		 5tzoB-5a3jA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3v BILIVERDIN REDUCTASE

(Synechocystis
sp. PCC 6803) 		no annotation 5 LEU B  37
PHE B  40
ALA B  21
ALA B  22
GLY B  19
 None
None
NAP  B 401 (-3.5A)
None
NAP  B 401 (-3.1A)
 1.11A 5tzoB-5b3vB:
undetectable		 5tzoB-5b3vB:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum) 		PF00400
(WD40)
PF08154
(NLE) 		5 LEU A 221
VAL A 200
ALA A 182
ALA A 194
GLY A 195
 None
 1.17A 5tzoB-5cykA:
undetectable		 5tzoB-5cykA:
17.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ej3 ENDO-1,4-BETA-XYLANA
SE B

(Streptomyces
lividans) 		PF00457
(Glyco_hydro_11) 		6 VAL A  48
TRP A  80
TYR A  89
TRP A 137
TYR A 171
GLY A 178
 None
 0.79A 5tzoB-5ej3A:
27.5		 5tzoB-5ej3A:
49.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4i PHOSPHOLYASE

(Paenarthrobacter
aurescens) 		PF00202
(Aminotran_3) 		5 LEU A 205
VAL A 212
ALA A 243
ALA A 244
GLY A 245
 None
 1.03A 5tzoB-5g4iA:
undetectable		 5tzoB-5g4iA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j44 SERINE PROTEASE SEPA
AUTOTRANSPORTER

(Shigella
flexneri) 		PF02395
(Peptidase_S6) 		5 LEU A 666
SER A 711
VAL A 664
ALA A 642
TYR A 701
 None
 1.13A 5tzoB-5j44A:
undetectable		 5tzoB-5j44A:
13.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jrm ENDO-1,4-BETA-XYLANA
SE

(Fusarium
oxysporum) 		PF00457
(Glyco_hydro_11) 		5 TRP A  78
TYR A  87
TRP A 137
TYR A 170
GLY A 177
 GOL  A 201 ( 3.7A)
None
None
None
None
 0.80A 5tzoB-5jrmA:
27.6		 5tzoB-5jrmA:
47.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jrm ENDO-1,4-BETA-XYLANA
SE

(Fusarium
oxysporum) 		PF00457
(Glyco_hydro_11) 		5 VAL A  46
TRP A  78
TYR A  87
TRP A 137
GLY A 177
 GOL  A 201 ( 4.7A)
GOL  A 201 ( 3.7A)
None
None
None
 0.96A 5tzoB-5jrmA:
27.6		 5tzoB-5jrmA:
47.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldn HEXON PROTEIN,HEXON
CAPSID

(Human
mastadenovirus
C) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		5 LEU A 915
PHE A 679
VAL A 917
ALA A 649
TRP A 671
 None
 1.01A 5tzoB-5ldnA:
undetectable		 5tzoB-5ldnA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncc FATTY ACID
PHOTODECARBOXYLASE

(Chlorella
variabilis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 LEU A 511
VAL A 344
ALA A 610
ALA A 343
GLY A 342
 None
None
FAD  A 701 (-3.5A)
None
FAD  A 701 (-3.2A)
 1.11A 5tzoB-5nccA:
undetectable		 5tzoB-5nccA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngd PORTAL PROTEIN

(Thermus virus
P74-26) 		no annotation 5 LEU A 344
SER A 213
ALA A 134
ALA A 128
GLY A 132
 None
 1.15A 5tzoB-5ngdA:
undetectable		 5tzoB-5ngdA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE

(Homo sapiens) 		no annotation 5 LEU A 587
VAL A 597
TRP A 499
ALA A 610
GLY A 611
 None
 0.94A 5tzoB-5nn8A:
undetectable		 5tzoB-5nn8A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o16 AMBC

(Sorangium
cellulosum) 		no annotation 5 LEU A  69
SER A 243
VAL A 245
ALA A 287
GLY A 288
 None
 1.06A 5tzoB-5o16A:
undetectable		 5tzoB-5o16A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uni NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Thermus
thermophilus) 		PF02233
(PNTB) 		5 LEU B 123
PHE B 190
VAL B 127
ALA B 128
GLY B 131
 PEG  B 308 ( 4.6A)
None
None
None
None
 1.17A 5tzoB-5uniB:
undetectable		 5tzoB-5uniB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Neisseria
gonorrhoeae) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 SER A 210
ALA A 216
TYR A 313
ALA A 213
GLY A 212
 None
 1.17A 5tzoB-5vmtA:
undetectable		 5tzoB-5vmtA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8q BIS3 BIPHENYL
SYNTHASE

(Malus domestica) 		no annotation 5 LEU A 143
SER A 215
ALA A  16
ALA A 108
GLY A  18
 None
 1.18A 5tzoB-5w8qA:
undetectable		 5tzoB-5w8qA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyj ACETYL-COA
ACETYLTRANSFERASE

(Saccharomyces
cerevisiae) 		no annotation 5 SER B 391
VAL B 301
TRP B 283
ALA B 304
GLY B 284
 None
 1.09A 5tzoB-5xyjB:
undetectable		 5tzoB-5xyjB:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yak -

(-) 		no annotation 5 LEU A 260
SER A 128
VAL A 217
ALA A 123
ALA A 220
 None
 1.18A 5tzoB-5yakA:
undetectable		 5tzoB-5yakA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yeq KETOL-ACID
REDUCTOISOMERASE
(NADP(+))

(Sulfolobus
acidocaldarius) 		no annotation 5 LEU A  36
VAL A  20
ALA A  70
TRP A  32
ALA A  21
 None
 1.21A 5tzoB-5yeqA:
undetectable		 5tzoB-5yeqA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aom ENDOPLASMIN

(Canis lupus) 		no annotation 5 LEU A 144
VAL A 250
ALA A 202
TRP A 223
ALA A 206
 None
 1.16A 5tzoB-6aomA:
undetectable		 5tzoB-6aomA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT C
ALTERNATIVE COMPLEX
III SUBUNIT D

(Flavobacterium
johnsoniae) 		no annotation 5 LEU C 234
VAL D 108
ALA D  57
ALA D 111
GLY D  61
 None
 1.16A 5tzoB-6btmC:
undetectable		 5tzoB-6btmC:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehy SCFV ANTIBODY
FRAGMENT

(Homo sapiens) 		no annotation 5 LEU A  45
SER A  35
VAL A  37
ALA A  61
GLY A  49
 None
 1.19A 5tzoB-6ehyA:
undetectable		 5tzoB-6ehyA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et0 PQSB

(Pseudomonas
aeruginosa) 		no annotation 5 LEU B  88
VAL B  42
ALA B   5
ALA B  45
GLY B   7
 None
 1.14A 5tzoB-6et0B:
undetectable		 5tzoB-6et0B:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB

(Yersinia
pseudotuberculosis) 		no annotation 5 LEU A 251
VAL A 274
ALA A 311
ALA A 169
GLY A 170
 LEU  A 251 ( 0.5A)
VAL  A 274 ( 0.6A)
ALA  A 311 ( 0.0A)
ALA  A 169 ( 0.0A)
GLY  A 170 ( 0.0A)
 1.12A 5tzoB-6gefA:
undetectable		 5tzoB-6gefA:
16.85