SIMILAR PATTERNS OF AMINO ACIDS FOR 5TZO_B_7V7B201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1axk GLUXYN-1

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11)
PF00722
(Glyco_hydro_16) 		6 VAL A 193
TRP A 227
TYR A 236
TRP A 285
TYR A 322
GLY A 329
 None
 0.61A 5tzoB-1axkA:
34.6		 5tzoB-1axkA:
58.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl6 ATPASE

(Escherichia
coli) 		PF10412
(TrwB_AAD_bind) 		5 LEU A 413
SER A 409
VAL A 411
ALA A 486
GLY A 478
 None
 0.94A 5tzoB-1gl6A:
undetectable		 5tzoB-1gl6A:
18.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h1a ENDO-1,4-BETA-XYLANA
SE

(Chaetomium
thermophilum) 		PF00457
(Glyco_hydro_11) 		6 VAL A  47
TRP A  80
TYR A  89
TRP A 139
TYR A 172
GLY A 179
 None
 0.69A 5tzoB-1h1aA:
28.8		 5tzoB-1h1aA:
52.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h39 SQUALENE--HOPENE
CYCLASE

(Alicyclobacillus
acidocaldarius) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		5 LEU A 475
VAL A 500
TRP A 558
ALA A 499
GLY A 498
 None
 1.20A 5tzoB-1h39A:
undetectable		 5tzoB-1h39A:
17.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hix ENDO-1,4-BETA-XYLANA
SE

(Streptomyces
sp. S38) 		PF00457
(Glyco_hydro_11) 		6 VAL A  48
TRP A  80
TYR A  89
TRP A 137
TYR A 171
GLY A 178
 None
 0.54A 5tzoB-1hixA:
27.7		 5tzoB-1hixA:
54.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzv NITRITE REDUCTASE

(Pseudomonas
aeruginosa) 		PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3) 		5 LEU A 194
VAL A 227
ALA A 251
ALA A 242
GLY A 243
 None
 1.05A 5tzoB-1hzvA:
0.0		 5tzoB-1hzvA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE

(Cucurbita
moschata) 		PF01553
(Acyltransferase)
PF14829
(GPAT_N) 		5 LEU A 213
SER A 191
VAL A 189
TRP A 228
GLY A 168
 None
 1.16A 5tzoB-1iuqA:
undetectable		 5tzoB-1iuqA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhk IG GAMMA-1-CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU H  45
VAL H  37
TRP H  50
TRP H  95
GLY H  49
 None
 1.19A 5tzoB-1jhkH:
undetectable		 5tzoB-1jhkH:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE

(Pyrococcus
horikoshii) 		PF06026
(Rib_5-P_isom_A) 		5 LEU A 120
VAL A  84
ALA A 114
ALA A  83
GLY A  25
 None
 1.14A 5tzoB-1lk5A:
0.0		 5tzoB-1lk5A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p2z HEXON PROTEIN

(Human
mastadenovirus
C) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		5 LEU A 931
PHE A 695
VAL A 933
ALA A 665
TRP A 687
 None
 1.01A 5tzoB-1p2zA:
undetectable		 5tzoB-1p2zA:
10.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pvx PROTEIN
(ENDO-1,4-BETA-XYLAN
ASE)

(Byssochlamys
spectabilis) 		PF00457
(Glyco_hydro_11) 		5 VAL A  46
TRP A  79
TYR A  88
TRP A 138
TYR A 172
 None
 0.71A 5tzoB-1pvxA:
27.1		 5tzoB-1pvxA:
45.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry2 ACETYL-COENZYME A
SYNTHETASE 1

(Saccharomyces
cerevisiae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 LEU A 417
VAL A 412
TYR A 454
ALA A 360
GLY A 361
 None
 1.14A 5tzoB-1ry2A:
undetectable		 5tzoB-1ry2A:
15.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1te1 ENDO-1,4-XYLANASE

(Talaromyces
funiculosus) 		PF00457
(Glyco_hydro_11) 		5 TRP B  78
TYR B  87
TRP B 137
TYR B 170
GLY B 177
 None
 0.72A 5tzoB-1te1B:
26.8		 5tzoB-1te1B:
45.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkr POLYPOROPEPSIN

(Irpex lacteus) 		PF00026
(Asp) 		5 LEU A 142
SER A   4
ALA A   1
ALA A   2
GLY A   3
 None
 1.03A 5tzoB-1wkrA:
undetectable		 5tzoB-1wkrA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9j PROBABLE BUTYRATE
KINASE 2

(Thermotoga
maritima) 		PF00871
(Acetate_kinase) 		5 SER A 106
ALA A 113
TYR A 355
ALA A 110
GLY A 109
 None
 1.10A 5tzoB-1x9jA:
undetectable		 5tzoB-1x9jA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y80 PREDICTED COBALAMIN
BINDING PROTEIN

(Moorella
thermoacetica) 		PF02310
(B12-binding) 		5 LEU A 163
VAL A 174
ALA A 186
ALA A 191
GLY A 193
 None
 1.17A 5tzoB-1y80A:
undetectable		 5tzoB-1y80A:
21.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yna ENDO-1,4-BETA-XYLANA
SE

(Thermomyces
lanuginosus) 		PF00457
(Glyco_hydro_11) 		5 VAL A  46
TRP A  79
TYR A  88
TRP A 138
TYR A 172
 None
 0.58A 5tzoB-1ynaA:
27.7		 5tzoB-1ynaA:
44.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be3 GTP
PYROPHOSPHOKINASE

(Streptococcus
pneumoniae) 		PF04607
(RelA_SpoT) 		5 LEU A   9
VAL A  46
ALA A 138
ALA A  74
GLY A  75
 None
 1.13A 5tzoB-2be3A:
undetectable		 5tzoB-2be3A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6k TRANSKETOLASE

(Thermus
thermophilus) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		6 LEU A 536
SER A 551
VAL A 553
ALA A 601
TYR A 534
ALA A 548
 None
 1.37A 5tzoB-2e6kA:
undetectable		 5tzoB-2e6kA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqx MEMBRANE LIPOPROTEIN
TMPC

(Treponema
pallidum) 		PF02608
(Bmp) 		5 LEU A  80
SER A  45
ALA A 262
ALA A 266
GLY A  43
 None
 1.18A 5tzoB-2fqxA:
undetectable		 5tzoB-2fqxA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus sp.
GL1) 		PF07470
(Glyco_hydro_88) 		5 ALA A 281
TRP A 372
TYR A 356
ALA A 224
GLY A 222
 None
 1.20A 5tzoB-2fv0A:
undetectable		 5tzoB-2fv0A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF01571
(GCV_T)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4) 		5 LEU A 167
SER A 430
ALA A 248
ALA A 139
GLY A 432
 None
None
NAD  A 999 (-4.8A)
NAD  A 999 (-3.2A)
None
 1.14A 5tzoB-2gahA:
undetectable		 5tzoB-2gahA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0k OXIDOREDUCTASE

(Brevibacterium
sterolicum) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		5 LEU A 289
SER A 307
ALA A 204
ALA A 310
GLY A 309
 None
 1.16A 5tzoB-2i0kA:
undetectable		 5tzoB-2i0kA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran) 		5 ALA A1907
TRP A1757
TYR A1754
ALA A1908
GLY A1909
 None
 1.19A 5tzoB-2ix8A:
undetectable		 5tzoB-2ix8A:
11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Saccharomyces
cerevisiae) 		PF00156
(Pribosyltran) 		5 LEU A 107
PHE A 154
VAL A 109
ALA A  63
ALA A  35
 None
 1.14A 5tzoB-2jkyA:
undetectable		 5tzoB-2jkyA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jty TYPE-1 FIMBRIAL
PROTEIN, A CHAIN

(Escherichia
coli) 		PF00419
(Fimbrial) 		5 LEU A  88
VAL A  99
ALA A  47
ALA A 139
GLY A 141
 None
 1.20A 5tzoB-2jtyA:
undetectable		 5tzoB-2jtyA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jxm CYTOCHROME F

(Prochlorothrix
hollandica) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		5 LEU B  83
VAL B 104
ALA B  73
ALA B 117
GLY B 118
 None
None
None
None
HEC  B 250 ( 4.3A)
 1.03A 5tzoB-2jxmB:
undetectable		 5tzoB-2jxmB:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ka9 DISKS LARGE HOMOLOG
4

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 LEU A  86
SER A  82
VAL A  84
ALA A  80
GLY A  81
 None
 1.17A 5tzoB-2ka9A:
undetectable		 5tzoB-2ka9A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obe HEXON

(Human
mastadenovirus
E) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		5 LEU A 896
PHE A 660
VAL A 898
ALA A 630
TRP A 652
 None
 0.97A 5tzoB-2obeA:
undetectable		 5tzoB-2obeA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7a BACTERIAL HEME
BINDING PROTEIN

(Shigella
dysenteriae) 		PF01497
(Peripla_BP_2) 		5 LEU A 147
SER A 269
VAL A 267
ALA A 192
ALA A 190
 None
 1.15A 5tzoB-2r7aA:
undetectable		 5tzoB-2r7aA:
19.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vul GH11 XYLANASE

(Escherichia
coli) 		PF00457
(Glyco_hydro_11) 		6 VAL A  50
TRP A  82
TYR A  91
TRP A 142
TYR A 175
GLY A 182
 None
12P  A1199 ( 4.7A)
None
None
12P  A1199 (-4.2A)
None
 0.76A 5tzoB-2vulA:
28.5		 5tzoB-2vulA:
51.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9m POLYMERASE X

(Deinococcus
radiodurans) 		PF14520
(HHH_5)
PF14716
(HHH_8) 		5 LEU A 294
PHE A 291
VAL A 290
ALA A 242
GLY A 244
 None
 1.16A 5tzoB-2w9mA:
undetectable		 5tzoB-2w9mA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xec PUTATIVE MALEATE
ISOMERASE

(Nocardia
farcinica) 		no annotation 5 LEU A 122
SER A 224
ALA A 217
ALA A 220
GLY A 221
 None
 1.16A 5tzoB-2xecA:
undetectable		 5tzoB-2xecA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfs ORF12

(Streptomyces
clavuligerus) 		PF13354
(Beta-lactamase2) 		5 LEU A 340
VAL A 336
ALA A 257
ALA A 258
GLY A 259
 None
 1.18A 5tzoB-2xfsA:
undetectable		 5tzoB-2xfsA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aka PUTATIVE CALCIUM
BINDING PROTEIN

(Streptomyces
coelicolor) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		5 LEU A  60
SER A  28
ALA A  36
ALA A  33
GLY A  32
 None
 1.15A 5tzoB-3akaA:
undetectable		 5tzoB-3akaA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 SER A 185
VAL A 138
ALA A1009
ALA A 137
GLY A 136
 None
 1.19A 5tzoB-3cmtA:
undetectable		 5tzoB-3cmtA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 SER A1185
VAL A1138
ALA A2009
ALA A1137
GLY A1136
 None
 1.21A 5tzoB-3cmtA:
undetectable		 5tzoB-3cmtA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 SER A2185
VAL A2138
ALA A3009
ALA A2137
GLY A2136
 None
 1.21A 5tzoB-3cmtA:
undetectable		 5tzoB-3cmtA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 SER A3185
VAL A3138
ALA A4009
ALA A3137
GLY A3136
 None
 1.19A 5tzoB-3cmtA:
undetectable		 5tzoB-3cmtA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 SER A4185
VAL A4138
ALA A5009
ALA A4137
GLY A4136
 None
 1.20A 5tzoB-3cmuA:
undetectable		 5tzoB-3cmuA:
5.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gh8 IODOTYROSINE
DEHALOGENASE 1

(Mus musculus) 		PF00881
(Nitroreductase) 		5 LEU A 256
SER A 124
VAL A 213
ALA A 119
ALA A 216
 None
 1.20A 5tzoB-3gh8A:
undetectable		 5tzoB-3gh8A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER

(Rhodospirillum
rubrum) 		PF13458
(Peripla_BP_6) 		5 LEU A 326
VAL A 322
ALA A 155
ALA A 321
GLY A 318
 None
 1.21A 5tzoB-3hutA:
undetectable		 5tzoB-3hutA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6y ESTERASE APC40077

(Oleispira
antarctica) 		PF00756
(Esterase) 		5 LEU A 249
SER A 148
ALA A 145
ALA A 170
GLY A 151
 None
CL  A 280 (-3.0A)
None
None
None
 1.16A 5tzoB-3i6yA:
undetectable		 5tzoB-3i6yA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j97 VESICLE-FUSING
ATPASE

(Cricetulus
griseus) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2) 		5 LEU A  16
SER A  25
VAL A  23
ALA A   9
ALA A  61
 None
 1.16A 5tzoB-3j97A:
undetectable		 5tzoB-3j97A:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 SER A 207
ALA A 213
TYR A 311
ALA A 210
GLY A 209
 None
None
None
SO4  A 337 (-3.3A)
SO4  A 337 (-4.0A)
 1.15A 5tzoB-3k2bA:
undetectable		 5tzoB-3k2bA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9d PUTATIVE GTP
PYROPHOSPHOKINASE

(Streptococcus
mutans) 		PF04607
(RelA_SpoT) 		5 LEU A   7
VAL A  44
ALA A 136
ALA A  72
GLY A  73
 None
 1.18A 5tzoB-3l9dA:
undetectable		 5tzoB-3l9dA:
20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lb9 ENDO-1,4-BETA-XYLANA
SE

(Bacillus
circulans) 		PF00457
(Glyco_hydro_11) 		6 VAL A 102
TRP A 136
TYR A 145
TRP A   8
TYR A  45
GLY A  52
 None
 0.58A 5tzoB-3lb9A:
12.4		 5tzoB-3lb9A:
60.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lps TOPOISOMERASE IV
SUBUNIT B

(Xanthomonas
oryzae) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		5 LEU A 267
PHE A 361
SER A 309
VAL A 362
ALA A 234
 None
 1.17A 5tzoB-3lpsA:
undetectable		 5tzoB-3lpsA:
17.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mf9 ENDO-1,4-BETA-XYLANA
SE

(Thermopolyspora
flexuosa) 		PF00457
(Glyco_hydro_11) 		5 VAL A  49
TRP A  81
TRP A 138
TYR A 171
GLY A 178
 None
 0.66A 5tzoB-3mf9A:
27.9		 5tzoB-3mf9A:
56.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndn O-SUCCINYLHOMOSERINE
SULFHYDRYLASE

(Mycobacterium
tuberculosis) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A 105
VAL A 101
ALA A 231
ALA A 100
GLY A  97
 None
None
None
None
LLP  A 219 ( 3.2A)
 1.17A 5tzoB-3ndnA:
undetectable		 5tzoB-3ndnA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3olo TWO-COMPONENT SENSOR
HISTIDINE KINASE

(Nostoc sp. PCC
7120) 		PF00989
(PAS) 		5 LEU A  26
SER A  95
VAL A 109
ALA A  22
TYR A  82
 None
 1.21A 5tzoB-3oloA:
undetectable		 5tzoB-3oloA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otn SUSD SUPERFAMILY
PROTEIN

(Parabacteroides
distasonis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 SER A 203
ALA A 216
TYR A  51
ALA A 213
GLY A 212
 None
None
EDO  A 634 ( 4.1A)
None
None
 1.02A 5tzoB-3otnA:
undetectable		 5tzoB-3otnA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbw ANHYDRO-N-ACETYLMURA
MIC ACID KINASE

(Pseudomonas
aeruginosa) 		PF03702
(AnmK) 		5 LEU A 219
VAL A 214
ALA A 209
ALA A 263
GLY A 212
 None
 1.07A 5tzoB-3qbwA:
undetectable		 5tzoB-3qbwA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rl7 DISKS LARGE HOMOLOG
1

(Homo sapiens) 		no annotation 5 LEU B 305
SER B 301
VAL B 303
ALA B 299
GLY B 300
 None
 1.18A 5tzoB-3rl7B:
undetectable		 5tzoB-3rl7B:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tua BURKHOLDERIA LETHAL
FACTOR 1 (BLF1)

(Burkholderia
pseudomallei) 		no annotation 5 LEU A  64
VAL A 104
ALA A 138
ALA A  98
GLY A  99
 None
 0.97A 5tzoB-3tuaA:
undetectable		 5tzoB-3tuaA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ui2 SIGNAL RECOGNITION
PARTICLE 43 KDA
PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF12796
(Ank_2) 		5 LEU A 179
VAL A 167
ALA A 201
ALA A 168
GLY A 169
 None
 1.21A 5tzoB-3ui2A:
undetectable		 5tzoB-3ui2A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2i PEPTIDYL-TRNA
HYDROLASE

(Burkholderia
thailandensis) 		PF01195
(Pept_tRNA_hydro) 		5 LEU A 131
VAL A 102
ALA A 172
ALA A 173
GLY A 100
 None
 1.12A 5tzoB-3v2iA:
undetectable		 5tzoB-3v2iA:
21.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vzm ENDO-1,4-BETA-XYLANA
SE

(Bacillus
circulans) 		PF00457
(Glyco_hydro_11) 		6 VAL A  37
TRP A  71
TYR A  80
TRP A 129
TYR A 166
GLY A 173
 XYP  A 202 (-4.9A)
XYP  A 202 ( 4.9A)
None
None
XYP  A 202 (-4.7A)
None
 0.58A 5tzoB-3vzmA:
35.0		 5tzoB-3vzmA:
91.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfa ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		5 LEU A 491
VAL A 249
TRP A 288
ALA A 246
ALA A 247
 None
 1.14A 5tzoB-3wfaA:
undetectable		 5tzoB-3wfaA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyh LYSOZYME G

(Struthio
camelus) 		PF01464
(SLT) 		5 LEU A 113
SER A  71
ALA A  64
ALA A  67
GLY A  68
 None
 1.12A 5tzoB-3wyhA:
undetectable		 5tzoB-3wyhA:
21.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zse ENDO-1,4-BETA-XYLANA
SE

(Thermobifida
fusca) 		PF00457
(Glyco_hydro_11) 		6 VAL A  88
TRP A 120
TYR A 129
TRP A 177
TYR A 210
GLY A 217
 FXP  A1207 (-4.7A)
FXP  A1207 (-4.6A)
None
None
FXP  A1207 (-4.7A)
None
 0.79A 5tzoB-3zseA:
28.6		 5tzoB-3zseA:
55.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b45 CELL DIVISION
PROTEIN FTSZ

(Haloferax
volcanii) 		PF00091
(Tubulin) 		5 LEU A   5
VAL A  31
ALA A 195
ALA A  30
GLY A  29
 None
 1.18A 5tzoB-4b45A:
undetectable		 5tzoB-4b45A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgu MALATE DEHYDROGENASE

(Haloferax
volcanii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A  30
VAL A   6
ALA A  10
ALA A   9
GLY A   8
 None
 1.21A 5tzoB-4bguA:
undetectable		 5tzoB-4bguA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dio NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1

(Sinorhizobium
meliloti) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 LEU A 317
VAL A 347
ALA A 355
ALA A 348
GLY A 349
 None
 1.15A 5tzoB-4dioA:
undetectable		 5tzoB-4dioA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f48 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Xanthomonas
campestris) 		PF00563
(EAL) 		5 LEU A  31
PHE A 227
VAL A 235
ALA A 241
GLY A 237
 None
 1.07A 5tzoB-4f48A:
undetectable		 5tzoB-4f48A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU

(Yersinia pestis) 		PF01032
(FecCD) 		6 LEU A 200
SER A 118
ALA A  96
TRP A 181
ALA A 123
GLY A 122
 None
 1.19A 5tzoB-4g1uA:
undetectable		 5tzoB-4g1uA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbz PUTATIVE
PHOSPHOHISTIDINE
PHOSPHATASE, SIXA

(Nakamurella
multipartita) 		PF00300
(His_Phos_1) 		5 SER A  29
ALA A  26
TYR A  91
ALA A  27
GLY A  28
 ACY  A 205 (-4.6A)
None
None
None
None
 1.02A 5tzoB-4hbzA:
undetectable		 5tzoB-4hbzA:
22.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hk9 ENDO-1,4-BETA-XYLANA
SE 2

(Trichoderma
reesei) 		PF00457
(Glyco_hydro_11) 		6 VAL A  46
TRP A  79
TYR A  88
TRP A 138
TYR A 171
GLY A 178
 XYP  A 202 (-4.9A)
XYP  A 202 (-4.7A)
None
None
XYP  A 202 (-4.7A)
None
 0.71A 5tzoB-4hk9A:
29.4		 5tzoB-4hk9A:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksi LEUCINE
AMINOPEPTIDASE 1,
CHLOROPLASTIC

(Solanum
lycopersicum) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 LEU A 230
VAL A 208
ALA A 172
ALA A 171
GLY A 211
 None
 1.14A 5tzoB-4ksiA:
undetectable		 5tzoB-4ksiA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc9 GLUCOKINASE
REGULATORY PROTEIN

(Rattus
norvegicus) 		no annotation 5 LEU A 245
VAL A  86
ALA A 277
ALA A  87
GLY A  88
 None
 1.20A 5tzoB-4lc9A:
undetectable		 5tzoB-4lc9A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nuh ICE-BINDING PROTEIN

(Leucosporidium) 		PF11999
(DUF3494) 		5 LEU A 184
SER A 160
VAL A 182
ALA A  16
GLY A 199
 None
 1.19A 5tzoB-4nuhA:
undetectable		 5tzoB-4nuhA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oju HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN

(Pseudoflavonifractor
capillosus) 		PF13306
(LRR_5) 		5 LEU A 118
SER A 114
VAL A 116
ALA A  61
GLY A  92
 None
 1.17A 5tzoB-4ojuA:
undetectable		 5tzoB-4ojuA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s2t PROTEIN APP-1

(Caenorhabditis
elegans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		5 LEU P 287
VAL P 285
ALA P 231
TRP P 268
ALA P 198
 None
 0.75A 5tzoB-4s2tP:
undetectable		 5tzoB-4s2tP:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w91 AMINOTRANSFERASE

(Brucella suis) 		PF00266
(Aminotran_5) 		5 LEU A  88
SER A  80
VAL A  84
ALA A 297
GLY A 295
 None
 1.19A 5tzoB-4w91A:
undetectable		 5tzoB-4w91A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjf D-AMINO-ACID OXIDASE

(Sus scrofa) 		PF01266
(DAO) 		5 PHE B 213
ALA B  48
TYR B 224
ALA B  49
GLY B  50
 None
FAD  B 401 (-3.6A)
98B  B 404 (-3.3A)
FAD  B 401 (-3.2A)
FAD  B 401 (-3.9A)
 1.15A 5tzoB-4yjfB:
undetectable		 5tzoB-4yjfB:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0h GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
GAPC1, CYTOSOLIC

(Arabidopsis
thaliana) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 SER O 207
ALA O 213
TYR O 311
ALA O 210
GLY O 209
 None
None
None
SO4  O 403 ( 3.8A)
SO4  O 403 (-3.9A)
 1.07A 5tzoB-4z0hO:
undetectable		 5tzoB-4z0hO:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3j PUTATIVE
QUINONE-OXIDOREDUCTA
SE HOMOLOG,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		5 LEU A 284
VAL A  94
ALA A  42
ALA A  74
GLY A  75
 None
 0.79A 5tzoB-5a3jA:
undetectable		 5tzoB-5a3jA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3v BILIVERDIN REDUCTASE

(Synechocystis
sp. PCC 6803) 		no annotation 5 LEU B  37
PHE B  40
ALA B  21
ALA B  22
GLY B  19
 None
None
NAP  B 401 (-3.5A)
None
NAP  B 401 (-3.1A)
 1.11A 5tzoB-5b3vB:
undetectable		 5tzoB-5b3vB:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum) 		PF00400
(WD40)
PF08154
(NLE) 		5 LEU A 221
VAL A 200
ALA A 182
ALA A 194
GLY A 195
 None
 1.17A 5tzoB-5cykA:
undetectable		 5tzoB-5cykA:
17.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ej3 ENDO-1,4-BETA-XYLANA
SE B

(Streptomyces
lividans) 		PF00457
(Glyco_hydro_11) 		6 VAL A  48
TRP A  80
TYR A  89
TRP A 137
TYR A 171
GLY A 178
 None
 0.79A 5tzoB-5ej3A:
27.5		 5tzoB-5ej3A:
49.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4i PHOSPHOLYASE

(Paenarthrobacter
aurescens) 		PF00202
(Aminotran_3) 		5 LEU A 205
VAL A 212
ALA A 243
ALA A 244
GLY A 245
 None
 1.03A 5tzoB-5g4iA:
undetectable		 5tzoB-5g4iA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j44 SERINE PROTEASE SEPA
AUTOTRANSPORTER

(Shigella
flexneri) 		PF02395
(Peptidase_S6) 		5 LEU A 666
SER A 711
VAL A 664
ALA A 642
TYR A 701
 None
 1.13A 5tzoB-5j44A:
undetectable		 5tzoB-5j44A:
13.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jrm ENDO-1,4-BETA-XYLANA
SE

(Fusarium
oxysporum) 		PF00457
(Glyco_hydro_11) 		5 TRP A  78
TYR A  87
TRP A 137
TYR A 170
GLY A 177
 GOL  A 201 ( 3.7A)
None
None
None
None
 0.80A 5tzoB-5jrmA:
27.6		 5tzoB-5jrmA:
47.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jrm ENDO-1,4-BETA-XYLANA
SE

(Fusarium
oxysporum) 		PF00457
(Glyco_hydro_11) 		5 VAL A  46
TRP A  78
TYR A  87
TRP A 137
GLY A 177
 GOL  A 201 ( 4.7A)
GOL  A 201 ( 3.7A)
None
None
None
 0.96A 5tzoB-5jrmA:
27.6		 5tzoB-5jrmA:
47.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldn HEXON PROTEIN,HEXON
CAPSID

(Human
mastadenovirus
C) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		5 LEU A 915
PHE A 679
VAL A 917
ALA A 649
TRP A 671
 None
 1.01A 5tzoB-5ldnA:
undetectable		 5tzoB-5ldnA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncc FATTY ACID
PHOTODECARBOXYLASE

(Chlorella
variabilis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 LEU A 511
VAL A 344
ALA A 610
ALA A 343
GLY A 342
 None
None
FAD  A 701 (-3.5A)
None
FAD  A 701 (-3.2A)
 1.11A 5tzoB-5nccA:
undetectable		 5tzoB-5nccA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngd PORTAL PROTEIN

(Thermus virus
P74-26) 		no annotation 5 LEU A 344
SER A 213
ALA A 134
ALA A 128
GLY A 132
 None
 1.15A 5tzoB-5ngdA:
undetectable		 5tzoB-5ngdA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE

(Homo sapiens) 		no annotation 5 LEU A 587
VAL A 597
TRP A 499
ALA A 610
GLY A 611
 None
 0.94A 5tzoB-5nn8A:
undetectable		 5tzoB-5nn8A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o16 AMBC

(Sorangium
cellulosum) 		no annotation 5 LEU A  69
SER A 243
VAL A 245
ALA A 287
GLY A 288
 None
 1.06A 5tzoB-5o16A:
undetectable		 5tzoB-5o16A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uni NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Thermus
thermophilus) 		PF02233
(PNTB) 		5 LEU B 123
PHE B 190
VAL B 127
ALA B 128
GLY B 131
 PEG  B 308 ( 4.6A)
None
None
None
None
 1.17A 5tzoB-5uniB:
undetectable		 5tzoB-5uniB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Neisseria
gonorrhoeae) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 SER A 210
ALA A 216
TYR A 313
ALA A 213
GLY A 212
 None
 1.17A 5tzoB-5vmtA:
undetectable		 5tzoB-5vmtA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8q BIS3 BIPHENYL
SYNTHASE

(Malus domestica) 		no annotation 5 LEU A 143
SER A 215
ALA A  16
ALA A 108
GLY A  18
 None
 1.18A 5tzoB-5w8qA:
undetectable		 5tzoB-5w8qA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyj ACETYL-COA
ACETYLTRANSFERASE

(Saccharomyces
cerevisiae) 		no annotation 5 SER B 391
VAL B 301
TRP B 283
ALA B 304
GLY B 284
 None
 1.09A 5tzoB-5xyjB:
undetectable		 5tzoB-5xyjB:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yak -

(-) 		no annotation 5 LEU A 260
SER A 128
VAL A 217
ALA A 123
ALA A 220
 None
 1.18A 5tzoB-5yakA:
undetectable		 5tzoB-5yakA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yeq KETOL-ACID
REDUCTOISOMERASE
(NADP(+))

(Sulfolobus
acidocaldarius) 		no annotation 5 LEU A  36
VAL A  20
ALA A  70
TRP A  32
ALA A  21
 None
 1.21A 5tzoB-5yeqA:
undetectable		 5tzoB-5yeqA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aom ENDOPLASMIN

(Canis lupus) 		no annotation 5 LEU A 144
VAL A 250
ALA A 202
TRP A 223
ALA A 206
 None
 1.16A 5tzoB-6aomA:
undetectable		 5tzoB-6aomA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT C
ALTERNATIVE COMPLEX
III SUBUNIT D

(Flavobacterium
johnsoniae) 		no annotation 5 LEU C 234
VAL D 108
ALA D  57
ALA D 111
GLY D  61
 None
 1.16A 5tzoB-6btmC:
undetectable		 5tzoB-6btmC:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehy SCFV ANTIBODY
FRAGMENT

(Homo sapiens) 		no annotation 5 LEU A  45
SER A  35
VAL A  37
ALA A  61
GLY A  49
 None
 1.19A 5tzoB-6ehyA:
undetectable		 5tzoB-6ehyA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et0 PQSB

(Pseudomonas
aeruginosa) 		no annotation 5 LEU B  88
VAL B  42
ALA B   5
ALA B  45
GLY B   7
 None
 1.14A 5tzoB-6et0B:
undetectable		 5tzoB-6et0B:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB

(Yersinia
pseudotuberculosis) 		no annotation 5 LEU A 251
VAL A 274
ALA A 311
ALA A 169
GLY A 170
 LEU  A 251 ( 0.5A)
VAL  A 274 ( 0.6A)
ALA  A 311 ( 0.0A)
ALA  A 169 ( 0.0A)
GLY  A 170 ( 0.0A)
 1.12A 5tzoB-6gefA:
undetectable		 5tzoB-6gefA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amo NADPH-CYTOCHROME
P450 REDUCTASE

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		3 ARG A 450
PRO A 362
TYR A 323
 None
 0.70A 5tzoB-1amoA:
undetectable		 5tzoB-1amoA:
15.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1axk GLUXYN-1

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11)
PF00722
(Glyco_hydro_16) 		3 ARG A 268
PRO A 272
TYR A 330
 None
 0.58A 5tzoB-1axkA:
34.6		 5tzoB-1axkA:
58.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dhs DEOXYHYPUSINE
SYNTHASE

(Homo sapiens) 		PF01916
(DS) 		3 ARG A  61
PRO A 336
TYR A 340
 None
 0.94A 5tzoB-1dhsA:
undetectable		 5tzoB-1dhsA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6z CHITINASE B

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		3 ARG A  89
PRO A 178
TYR A 208
 None
 1.02A 5tzoB-1e6zA:
undetectable		 5tzoB-1e6zA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1em2 MLN64 PROTEIN

(Homo sapiens) 		PF01852
(START) 		3 ARG A 380
PRO A 373
TYR A 378
 None
 1.01A 5tzoB-1em2A:
undetectable		 5tzoB-1em2A:
21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1f5j BETA-1,4-XYLANASE

(Dictyoglomus
thermophilum) 		PF00457
(Glyco_hydro_11) 		3 ARG A 125
PRO A 129
TYR A 182
 None
 0.78A 5tzoB-1f5jA:
25.6		 5tzoB-1f5jA:
42.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN

(Panulirus
interruptus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 ARG A 107
PRO A  24
TYR A  27
 None
 1.06A 5tzoB-1hcyA:
undetectable		 5tzoB-1hcyA:
15.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hix ENDO-1,4-BETA-XYLANA
SE

(Streptomyces
sp. S38) 		PF00457
(Glyco_hydro_11) 		3 ARG A 121
PRO A 125
TYR A 179
 None
 0.80A 5tzoB-1hixA:
27.7		 5tzoB-1hixA:
54.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i41 CYSTATHIONINE
GAMMA-SYNTHASE

(Nicotiana
tabacum) 		PF01053
(Cys_Met_Meta_PP) 		3 ARG A 423
PRO A 387
TYR A 404
 HEN  A 500 (-3.3A)
HEN  A 500 (-3.8A)
None
 0.93A 5tzoB-1i41A:
undetectable		 5tzoB-1i41A:
19.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1igo FAMILY 11 XYLANASE

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11) 		3 ARG A 128
PRO A 132
TYR A 185
 None
 0.81A 5tzoB-1igoA:
25.2		 5tzoB-1igoA:
48.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH) 		3 ARG A 382
PRO A 438
TYR A 363
 None
 0.96A 5tzoB-1lrtA:
undetectable		 5tzoB-1lrtA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lw7 TRANSCRIPTIONAL
REGULATOR NADR

(Haemophilus
influenzae) 		PF01467
(CTP_transf_like)
PF13521
(AAA_28) 		3 ARG A 110
PRO A 223
TYR A 332
 None
 0.81A 5tzoB-1lw7A:
undetectable		 5tzoB-1lw7A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH)
PF00571
(CBS) 		3 ARG A 382
PRO A 438
TYR A 363
 None
 0.91A 5tzoB-1mewA:
undetectable		 5tzoB-1mewA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		3 ARG A 253
PRO A 402
TYR A 398
 None
 0.90A 5tzoB-1mlzA:
undetectable		 5tzoB-1mlzA:
18.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pvx PROTEIN
(ENDO-1,4-BETA-XYLAN
ASE)

(Byssochlamys
spectabilis) 		PF00457
(Glyco_hydro_11) 		3 ARG A 122
PRO A 126
TYR A 180
 None
 0.88A 5tzoB-1pvxA:
27.1		 5tzoB-1pvxA:
45.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qi9 PROTEIN (VANADIUM
BROMOPEROXIDASE)

(Ascophyllum
nodosum) 		no annotation 3 ARG A 196
PRO A 206
TYR A 155
 None
 1.06A 5tzoB-1qi9A:
undetectable		 5tzoB-1qi9A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r76 PECTATE LYASE

(Niveispirillum
irakense) 		PF09492
(Pec_lyase) 		3 ARG A 162
PRO A  81
TYR A 141
 None
 0.61A 5tzoB-1r76A:
undetectable		 5tzoB-1r76A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sdd COAGULATION FACTOR V

(Bos taurus) 		PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3) 		3 ARG B1778
PRO B1775
TYR B1956
 None
 0.78A 5tzoB-1sddB:
undetectable		 5tzoB-1sddB:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1u CHOLINE
O-ACETYLTRANSFERASE

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		3 ARG A 463
PRO A 444
TYR A 539
 None
 0.75A 5tzoB-1t1uA:
undetectable		 5tzoB-1t1uA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		3 ARG A 337
PRO A 303
TYR A 332
 None
 1.00A 5tzoB-1tf0A:
undetectable		 5tzoB-1tf0A:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tj5 SUCROSE-PHOSPHATASE

(Synechocystis
sp. PCC 6803) 		PF05116
(S6PP) 		3 ARG A  32
PRO A  60
TYR A  36
 None
 1.07A 5tzoB-1tj5A:
undetectable		 5tzoB-1tj5A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up2 CELA1 PROTEIN

(Mycobacterium
tuberculosis) 		PF01341
(Glyco_hydro_6) 		3 ARG A 358
PRO A 322
TYR A 172
 None
None
SO4  A 385 (-4.8A)
 0.94A 5tzoB-1up2A:
undetectable		 5tzoB-1up2A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9l GLUTAMATE
DEHYDROGENASE

(Pyrobaculum
islandicum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		3 ARG A 400
PRO A 324
TYR A 334
 None
 1.09A 5tzoB-1v9lA:
undetectable		 5tzoB-1v9lA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy9 ALPHA-GALACTOSIDASE

(Thermotoga
maritima) 		PF02065
(Melibiase) 		3 ARG A 414
PRO A  67
TYR A 104
 None
 0.94A 5tzoB-1zy9A:
2.7		 5tzoB-1zy9A:
15.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dck XYLANASE J

(Bacillus sp.
41M-1) 		PF00457
(Glyco_hydro_11)
PF03422
(CBM_6) 		3 ARG A 128
PRO A 132
TYR A 185
 None
 0.88A 5tzoB-2dckA:
25.6		 5tzoB-2dckA:
31.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE

(Bacillus sp.
NG-27) 		PF00331
(Glyco_hydro_10) 		3 ARG A 290
PRO A 236
TYR A 298
 None
 1.03A 5tzoB-2f8qA:
undetectable		 5tzoB-2f8qA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		3 ARG A 317
PRO A 315
TYR A  95
 None
 1.03A 5tzoB-2fjaA:
undetectable		 5tzoB-2fjaA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fy2 CHOLINE
O-ACETYLTRANSFERASE

(Homo sapiens) 		PF00755
(Carn_acyltransf) 		3 ARG A 453
PRO A 434
TYR A 529
 None
 0.76A 5tzoB-2fy2A:
undetectable		 5tzoB-2fy2A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT

(Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 ARG A 142
PRO A 680
TYR A 655
 None
None
MD1  A1987 (-4.5A)
 0.97A 5tzoB-2ivfA:
undetectable		 5tzoB-2ivfA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lrn THIOL:DISULFIDE
INTERCHANGE PROTEIN

(Bacteroides sp.
4_3_47FAA) 		PF00578
(AhpC-TSA) 		3 ARG A 128
PRO A 111
TYR A  50
 None
 0.89A 5tzoB-2lrnA:
undetectable		 5tzoB-2lrnA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2no5 (S)-2-HALOACID
DEHALOGENASE IVA

(Burkholderia
cepacia) 		PF13419
(HAD_2) 		3 ARG A 194
PRO A 201
TYR A 204
 None
 0.74A 5tzoB-2no5A:
undetectable		 5tzoB-2no5A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pb7 E3 UBIQUITIN-PROTEIN
LIGASE UHRF1

(Homo sapiens) 		PF02182
(SAD_SRA) 		3 ARG A 582
PRO A 587
TYR A 555
 None
 1.01A 5tzoB-2pb7A:
undetectable		 5tzoB-2pb7A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE

(Escherichia
virus T7) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		3 ARG A 357
PRO A 248
TYR A 385
 None
 0.72A 5tzoB-2pi5A:
undetectable		 5tzoB-2pi5A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uwf ALKALINE ACTIVE
ENDOXYLANASE

(Bacillus
halodurans) 		PF00331
(Glyco_hydro_10) 		3 ARG A 296
PRO A 242
TYR A 304
 None
 0.96A 5tzoB-2uwfA:
undetectable		 5tzoB-2uwfA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7g UROCANATE HYDRATASE

(Pseudomonas
putida) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		3 ARG A 362
PRO A 360
TYR A  52
 ACT  A1558 (-2.9A)
None
ACT  A1558 ( 4.3A)
 1.03A 5tzoB-2v7gA:
undetectable		 5tzoB-2v7gA:
16.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vul GH11 XYLANASE

(Escherichia
coli) 		PF00457
(Glyco_hydro_11) 		3 ARG A 126
PRO A 130
TYR A 183
 None
12P  A1199 ( 4.6A)
None
 0.55A 5tzoB-2vulA:
28.5		 5tzoB-2vulA:
51.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w61 GLYCOLIPID-ANCHORED
SURFACE PROTEIN 2

(Saccharomyces
cerevisiae) 		PF03198
(Glyco_hydro_72)
PF07983
(X8) 		3 ARG A 207
PRO A 210
TYR A 128
 None
 0.96A 5tzoB-2w61A:
undetectable		 5tzoB-2w61A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwx GLCNAC-BINDING
PROTEIN A

(Vibrio cholerae) 		PF03067
(LPMO_10) 		3 ARG A 143
PRO A  77
TYR A 129
 None
 1.01A 5tzoB-2xwxA:
undetectable		 5tzoB-2xwxA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynk WZI

(Escherichia
coli) 		PF14052
(Caps_assemb_Wzi) 		3 ARG A  34
PRO A 177
TYR A 347
 None
 0.85A 5tzoB-2ynkA:
undetectable		 5tzoB-2ynkA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoy RBAM17540

(Bacillus
amyloliquefaciens) 		PF03067
(LPMO_10) 		3 ARG A 147
PRO A  78
TYR A 133
 None
 0.99A 5tzoB-2yoyA:
undetectable		 5tzoB-2yoyA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5c PROTEIN YPL144W
UNCHARACTERIZED
PROTEIN YLR021W

(Saccharomyces
cerevisiae) 		PF10448
(POC3_POC4) 		3 ARG B  43
PRO A  28
TYR A 113
 None
 1.05A 5tzoB-2z5cB:
undetectable		 5tzoB-2z5cB:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akf PUTATIVE SECRETED
ALPHA
L-ARABINOFURANOSIDAS
E II

(Streptomyces
avermitilis) 		PF04616
(Glyco_hydro_43)
PF05270
(AbfB) 		3 ARG A 279
PRO A 288
TYR A 220
 None
 0.88A 5tzoB-3akfA:
undetectable		 5tzoB-3akfA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvh 25-D1.16 LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ARG L  44
PRO L  58
TYR L  85
 None
 1.02A 5tzoB-3cvhL:
undetectable		 5tzoB-3cvhL:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edy TRIPEPTIDYL-PEPTIDAS
E 1

(Homo sapiens) 		PF09286
(Pro-kuma_activ) 		3 ARG A 492
PRO A 563
TYR A  79
 None
None
EDO  A 704 (-4.6A)
 1.04A 5tzoB-3edyA:
undetectable		 5tzoB-3edyA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoj BACTERIOCHLOROPHYLL
A PROTEIN

(Prosthecochloris
aestuarii) 		PF02327
(BChl_A) 		3 ARG A 286
PRO A 134
TYR A 325
 None
 0.96A 5tzoB-3eojA:
undetectable		 5tzoB-3eojA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h04 UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF07859
(Abhydrolase_3) 		3 ARG A 180
PRO A 135
TYR A 221
 None
 1.06A 5tzoB-3h04A:
undetectable		 5tzoB-3h04A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h96 F420-H2 DEPENDENT
REDUCTASE A

(Mycolicibacterium
smegmatis) 		PF04075
(F420H2_quin_red) 		3 ARG A 132
PRO A  74
TYR A 111
 None
 0.94A 5tzoB-3h96A:
undetectable		 5tzoB-3h96A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hid ADENYLOSUCCINATE
SYNTHETASE

(Yersinia pestis) 		PF00709
(Adenylsucc_synt) 		3 ARG A 307
PRO A 280
TYR A 238
 None
 0.97A 5tzoB-3hidA:
undetectable		 5tzoB-3hidA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		3 ARG A 359
PRO A 433
TYR A 539
 None
 1.08A 5tzoB-3hjrA:
undetectable		 5tzoB-3hjrA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1u BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE

(Clostridium
acetobutylicum) 		PF04616
(Glyco_hydro_43) 		3 ARG A 279
PRO A 288
TYR A 220
 None
None
TRS  A 801 (-4.6A)
 1.02A 5tzoB-3k1uA:
undetectable		 5tzoB-3k1uA:
18.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lb9 ENDO-1,4-BETA-XYLANA
SE

(Bacillus
circulans) 		PF00457
(Glyco_hydro_11) 		3 ARG A 177
PRO A 181
TYR A  53
 None
 0.63A 5tzoB-3lb9A:
12.4		 5tzoB-3lb9A:
60.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mf9 ENDO-1,4-BETA-XYLANA
SE

(Thermopolyspora
flexuosa) 		PF00457
(Glyco_hydro_11) 		3 ARG A 122
PRO A 126
TYR A 179
 None
 0.95A 5tzoB-3mf9A:
27.9		 5tzoB-3mf9A:
56.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nom GLUTAMINE
CYCLOTRANSFERASE

(Zymomonas
mobilis) 		PF05096
(Glu_cyclase_2) 		3 ARG A 160
PRO A 199
TYR A 138
 None
 1.09A 5tzoB-3nomA:
undetectable		 5tzoB-3nomA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oft CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		3 ARG A 276
PRO A 321
TYR A 278
 None
 0.96A 5tzoB-3oftA:
undetectable		 5tzoB-3oftA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfs NADPH--CYTOCHROME
P450 REDUCTASE

(Homo sapiens) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		3 ARG A 453
PRO A 365
TYR A 326
 None
 0.77A 5tzoB-3qfsA:
undetectable		 5tzoB-3qfsA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uqz DNA PROCESSING
PROTEIN DPRA

(Streptococcus
pneumoniae) 		PF02481
(DNA_processg_A) 		3 ARG A 208
PRO A 206
TYR A 173
 None
 1.01A 5tzoB-3uqzA:
undetectable		 5tzoB-3uqzA:
18.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vzm ENDO-1,4-BETA-XYLANA
SE

(Bacillus
circulans) 		PF00457
(Glyco_hydro_11) 		3 ARG A 112
PRO A 116
TYR A 174
 DFX  A 201 (-3.9A)
DFX  A 201 (-3.9A)
None
 0.24A 5tzoB-3vzmA:
35.0		 5tzoB-3vzmA:
91.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zse ENDO-1,4-BETA-XYLANA
SE

(Thermobifida
fusca) 		PF00457
(Glyco_hydro_11) 		3 ARG A 161
PRO A 165
TYR A 218
 FXP  A1207 (-4.1A)
FXP  A1207 (-3.7A)
EDO  A1232 (-3.8A)
 0.53A 5tzoB-3zseA:
28.6		 5tzoB-3zseA:
55.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4beg PHOSPHATIDYLETHANOLA
MINE BINDING PROTEIN

(Mycobacterium
tuberculosis) 		PF01161
(PBP) 		3 ARG A 131
PRO A   5
TYR A  67
 None
 0.76A 5tzoB-4begA:
undetectable		 5tzoB-4begA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 2
GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 5

(Saccharomyces
cerevisiae) 		PF04054
(Not1)
PF04153
(NOT2_3_5) 		3 ARG B  51
PRO A1764
TYR C 460
 None
 1.05A 5tzoB-4by6B:
undetectable		 5tzoB-4by6B:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1u HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV

(Yersinia pestis) 		PF00005
(ABC_tran) 		3 ARG C  87
PRO C  80
TYR C  60
 None
 1.01A 5tzoB-4g1uC:
undetectable		 5tzoB-4g1uC:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq2 NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		3 ARG M 581
PRO M 555
TYR M 574
 None
 1.00A 5tzoB-4gq2M:
undetectable		 5tzoB-4gq2M:
10.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hk9 ENDO-1,4-BETA-XYLANA
SE 2

(Trichoderma
reesei) 		PF00457
(Glyco_hydro_11) 		3 ARG A 122
PRO A 126
TYR A 179
 XYP  A 203 (-3.7A)
XYP  A 203 ( 4.0A)
None
 0.36A 5tzoB-4hk9A:
29.4		 5tzoB-4hk9A:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4q BEL-BETA TREFOIL

(Boletus edulis) 		no annotation 3 ARG A  27
PRO A  32
TYR A  37
 GOL  A 201 (-4.0A)
None
GOL  A 201 ( 4.0A)
 1.03A 5tzoB-4i4qA:
undetectable		 5tzoB-4i4qA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4s BEL BETA-TREFOIL

(Boletus edulis) 		no annotation 3 ARG A  27
PRO A  32
TYR A  37
 GOL  A 203 (-3.9A)
None
GOL  A 203 (-3.6A)
 0.97A 5tzoB-4i4sA:
undetectable		 5tzoB-4i4sA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4s BEL BETA-TREFOIL

(Boletus edulis) 		no annotation 3 ARG A 121
PRO A 126
TYR A 131
 GOL  A 202 (-3.8A)
None
GOL  A 202 (-3.6A)
 0.97A 5tzoB-4i4sA:
undetectable		 5tzoB-4i4sA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idj FAB LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ARG L  45
PRO L  59
TYR L  86
 None
 1.06A 5tzoB-4idjL:
undetectable		 5tzoB-4idjL:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Saccharomyces
cerevisiae) 		PF03200
(Glyco_hydro_63)
PF16923
(Glyco_hydro_63N) 		3 ARG A 698
PRO A 684
TYR A 691
 None
 0.96A 5tzoB-4j5tA:
undetectable		 5tzoB-4j5tA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt0 MTRE PROTEIN

(Neisseria
gonorrhoeae) 		PF02321
(OEP) 		3 ARG A 193
PRO A 216
TYR A 413
 None
 0.99A 5tzoB-4mt0A:
undetectable		 5tzoB-4mt0A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ony EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 5

(Brucella
melitensis) 		PF00496
(SBP_bac_5) 		3 ARG A 351
PRO A 395
TYR A 452
 None
 0.76A 5tzoB-4onyA:
undetectable		 5tzoB-4onyA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmz XYLANASE

(Xanthomonas
citri) 		PF00331
(Glyco_hydro_10) 		3 ARG A 311
PRO A 260
TYR A 269
 None
 0.95A 5tzoB-4pmzA:
undetectable		 5tzoB-4pmzA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		3 ARG A 337
PRO A 303
TYR A 332
 None
 1.01A 5tzoB-4po0A:
undetectable		 5tzoB-4po0A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rn3 HAD SUPERFAMILY
HYDROLASE

(Geobacter
sulfurreducens) 		PF13419
(HAD_2) 		3 ARG A 200
PRO A 194
TYR A 191
 None
 1.08A 5tzoB-4rn3A:
undetectable		 5tzoB-4rn3A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvw ZNUD

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ARG A 486
PRO A 488
TYR A 545
 None
 1.08A 5tzoB-4rvwA:
undetectable		 5tzoB-4rvwA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tuw HISTONE RNA
HAIRPIN-BINDING
PROTEIN

(Drosophila
melanogaster) 		PF15247
(SLBP_RNA_bind) 		3 ARG A 229
PRO A 219
TYR A 211
 None
 1.03A 5tzoB-4tuwA:
undetectable		 5tzoB-4tuwA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnz LIGHT CHAIN OF
ANTIBODY VRC06B

(Homo sapiens) 		no annotation 3 ARG L  44
PRO L  58
TYR L  85
 None
 0.99A 5tzoB-4xnzL:
undetectable		 5tzoB-4xnzL:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a11 THIOCYANATE FORMING
PROTEIN

(Thlaspi arvense) 		PF01344
(Kelch_1) 		3 ARG A  94
PRO A 155
TYR A  45
 None
 1.03A 5tzoB-5a11A:
undetectable		 5tzoB-5a11A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus) 		PF01398
(JAB)
PF01399
(PCI)
PF13012
(MitMem_reg) 		3 ARG F 110
PRO F 254
TYR M 139
 None
 0.92A 5tzoB-5a5tF:
undetectable		 5tzoB-5a5tF:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		3 ARG A 193
PRO A  45
TYR A  88
 None
 0.93A 5tzoB-5cjfA:
undetectable		 5tzoB-5cjfA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ecu CELLULASE

(Caldicellulosiruptor
saccharolyticus) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		3 ARG A 367
PRO A 372
TYR A  38
 None
 1.08A 5tzoB-5ecuA:
undetectable		 5tzoB-5ecuA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fav CHOLINE
TRIMETHYLAMINE-LYASE

(Desulfovibrio
alaskensis) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 ARG A 274
PRO A 112
TYR A 106
 None
None
MLI  A 904 (-4.5A)
 1.04A 5tzoB-5favA:
undetectable		 5tzoB-5favA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fm5 OBSCURIN-LIKE-1

(Homo sapiens) 		PF07679
(I-set) 		3 ARG O 296
PRO O 275
TYR O 268
 None
 1.00A 5tzoB-5fm5O:
undetectable		 5tzoB-5fm5O:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftz CHITIN BINDING
PROTEIN

(Streptomyces
lividans) 		PF03067
(LPMO_10) 		3 ARG A 142
PRO A  72
TYR A 128
 None
 0.94A 5tzoB-5ftzA:
undetectable		 5tzoB-5ftzA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		3 ARG A 337
PRO A 303
TYR A 332
 None
 1.00A 5tzoB-5ghkA:
undetectable		 5tzoB-5ghkA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpl PUTATIVE NUCLEOSOME
ASSEMBLY PROTEIN
C36B7.08C

(Schizosaccharomyces
pombe) 		PF00956
(NAP) 		3 ARG A  39
PRO A 191
TYR A  80
 None
 0.99A 5tzoB-5gplA:
undetectable		 5tzoB-5gplA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs1 LIGHT CHAIN

(Homo sapiens) 		PF07686
(V-set) 		3 ARG A  46
PRO A  60
TYR A  87
 None
 1.09A 5tzoB-5gs1A:
undetectable		 5tzoB-5gs1A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwe CYTOCHROME P450

(Corynebacterium
glutamicum) 		PF00067
(p450) 		3 ARG A 444
PRO A 446
TYR A 335
 SO4  A 503 (-3.1A)
None
SO4  A 503 (-4.0A)
 0.99A 5tzoB-5gweA:
undetectable		 5tzoB-5gweA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5icq METHYLOCYSTIS PARVUS
OBBP MBNE

(Methylocystis
parvus) 		PF00496
(SBP_bac_5) 		3 ARG A 362
PRO A 406
TYR A 462
 None
 0.84A 5tzoB-5icqA:
undetectable		 5tzoB-5icqA:
15.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jrm ENDO-1,4-BETA-XYLANA
SE

(Fusarium
oxysporum) 		PF00457
(Glyco_hydro_11) 		3 ARG A 121
PRO A 125
TYR A 178
 None
GOL  A 201 (-4.1A)
None
 0.77A 5tzoB-5jrmA:
27.6		 5tzoB-5jrmA:
47.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kxj L-ASPARTATE OXIDASE

(Salmonella
enterica) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		3 ARG A 444
PRO A 217
TYR A 213
 GOL  A 603 (-3.2A)
GOL  A 603 ( 4.5A)
None
 1.03A 5tzoB-5kxjA:
undetectable		 5tzoB-5kxjA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqs BETA-L-ARABINOBIOSID
ASE

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2) 		3 ARG A  59
PRO A 456
TYR A 361
 None
 0.80A 5tzoB-5mqsA:
6.0		 5tzoB-5mqsA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ori ALBUMIN

(Capra hircus) 		no annotation 3 ARG A 144
PRO A 113
TYR A 139
 None
 1.07A 5tzoB-5oriA:
undetectable		 5tzoB-5oriA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ori ALBUMIN

(Capra hircus) 		no annotation 3 ARG A 336
PRO A 302
TYR A 331
 None
 1.03A 5tzoB-5oriA:
undetectable		 5tzoB-5oriA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uy3 ANTIBODY PGT144 FAB
LIGHT CHAIN

(Homo sapiens) 		no annotation 3 ARG L  45
PRO L  59
TYR L  86
 None
 1.07A 5tzoB-5uy3L:
undetectable		 5tzoB-5uy3L:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjn CYTOCHROME P450

(Corynebacterium
glutamicum) 		PF00067
(p450) 		3 ARG A 417
PRO A 419
TYR A 308
 None
 1.06A 5tzoB-5xjnA:
undetectable		 5tzoB-5xjnA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 ARG A 470
PRO A 465
TYR B 833
 None
 1.08A 5tzoB-5xogA:
undetectable		 5tzoB-5xogA:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xon PROTEIN THAT FORMS A
COMPLEX WITH SPT4P
TRANSCRIPTION
ELONGATION FACTOR
SPT4

(Komagataella
phaffii) 		PF00467
(KOW)
PF03439
(Spt5-NGN)
PF06093
(Spt4) 		3 ARG V  73
PRO W 213
TYR V 104
 None
 1.01A 5tzoB-5xonV:
undetectable		 5tzoB-5xonV:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtb NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
12
NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL

(Homo sapiens) 		PF00384
(Molybdopterin)
PF05071
(NDUFA12)
PF09326
(NADH_dhqG_C)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4) 		3 ARG M 308
PRO M 578
TYR N 144
 None
 0.89A 5tzoB-5xtbM:
undetectable		 5tzoB-5xtbM:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE

(Pseudomonas
nitroreducens) 		no annotation 3 ARG A 439
PRO A 453
TYR A 463
 None
 1.03A 5tzoB-6em0A:
undetectable		 5tzoB-6em0A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gii CYTOCHROME P450

(Tepidiphilus
thermophilus) 		no annotation 3 ARG A 459
PRO A 461
TYR A 351
 None
 0.79A 5tzoB-6giiA:
undetectable		 5tzoB-6giiA:
16.67