SIMILAR PATTERNS OF AMINO ACIDS FOR 5TZO_A_7V7A202

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1axk GLUXYN-1

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11)
PF00722
(Glyco_hydro_16) 		7 VAL A 193
TRP A 227
TYR A 236
PRO A 272
TRP A 285
TYR A 322
GLY A 329
 None
 0.61A 5tzoA-1axkA:
34.6		 5tzoA-1axkA:
58.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bco BACTERIOPHAGE MU
TRANSPOSASE

(Escherichia
virus Mu) 		PF02914
(DDE_2)
PF09299
(Mu-transpos_C) 		5 PHE A 356
PRO A 537
TYR A 518
ALA A 514
GLY A 513
 None
 1.09A 5tzoA-1bcoA:
undetectable		 5tzoA-1bcoA:
22.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1f5j BETA-1,4-XYLANASE

(Dictyoglomus
thermophilum) 		PF00457
(Glyco_hydro_11) 		5 TRP A  83
TYR A  92
PRO A 129
TRP A 141
GLY A 181
 None
 0.71A 5tzoA-1f5jA:
25.4		 5tzoA-1f5jA:
42.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h1a ENDO-1,4-BETA-XYLANA
SE

(Chaetomium
thermophilum) 		PF00457
(Glyco_hydro_11) 		7 VAL A  47
TRP A  80
TYR A  89
PRO A 127
TRP A 139
TYR A 172
GLY A 179
 None
None
None
GOL  A1196 (-4.0A)
None
None
None
 0.72A 5tzoA-1h1aA:
28.8		 5tzoA-1h1aA:
52.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hix ENDO-1,4-BETA-XYLANA
SE

(Streptomyces
sp. S38) 		PF00457
(Glyco_hydro_11) 		6 VAL A  48
TRP A  80
TYR A  89
PRO A 125
TRP A 137
TYR A 171
 None
 0.56A 5tzoA-1hixA:
27.6		 5tzoA-1hixA:
54.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hix ENDO-1,4-BETA-XYLANA
SE

(Streptomyces
sp. S38) 		PF00457
(Glyco_hydro_11) 		6 VAL A  48
TRP A  80
TYR A  89
TRP A 137
TYR A 171
GLY A 178
 None
 0.63A 5tzoA-1hixA:
27.6		 5tzoA-1hixA:
54.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1igo FAMILY 11 XYLANASE

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11) 		5 TRP A  87
TYR A  96
PRO A 132
TRP A 144
GLY A 184
 None
 0.63A 5tzoA-1igoA:
25.2		 5tzoA-1igoA:
48.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00266
(Aminotran_5) 		5 VAL A 276
ALA A 285
PRO A 315
ALA A 286
GLY A 135
 None
 1.38A 5tzoA-1iugA:
undetectable		 5tzoA-1iugA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pq4 PERIPLASMIC BINDING
PROTEIN COMPONENT OF
AN ABC TYPE ZINC
UPTAKE TRANSPORTER

(Synechocystis
sp. PCC 6803) 		PF01297
(ZnuA) 		5 PHE A 288
VAL A 287
ALA A 303
ALA A 302
GLY A 308
 None
 1.38A 5tzoA-1pq4A:
undetectable		 5tzoA-1pq4A:
18.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pvx PROTEIN
(ENDO-1,4-BETA-XYLAN
ASE)

(Byssochlamys
spectabilis) 		PF00457
(Glyco_hydro_11) 		6 VAL A  46
TRP A  79
TYR A  88
PRO A 126
TRP A 138
TYR A 172
 None
 0.69A 5tzoA-1pvxA:
27.1		 5tzoA-1pvxA:
45.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5m PROSTAGLANDIN-E2
9-REDUCTASE

(Oryctolagus
cuniculus) 		PF00248
(Aldo_ket_red) 		5 VAL A 306
ALA A 311
TRP A  86
TYR A 216
ALA A 308
 None
None
None
NDP  A1003 (-3.2A)
None
 1.25A 5tzoA-1q5mA:
undetectable		 5tzoA-1q5mA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r88 MPT51/MPB51 ANTIGEN

(Mycobacterium
tuberculosis) 		PF00756
(Esterase) 		5 SER A  75
ALA A 101
TYR A 105
ALA A  70
GLY A  71
 None
 1.34A 5tzoA-1r88A:
undetectable		 5tzoA-1r88A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smq RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 1

(Saccharomyces
cerevisiae) 		PF00268
(Ribonuc_red_sm) 		5 SER A 244
ALA A 236
TRP A 216
TYR A 348
GLY A 240
 None
 1.35A 5tzoA-1smqA:
undetectable		 5tzoA-1smqA:
17.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1te1 ENDO-1,4-XYLANASE

(Talaromyces
funiculosus) 		PF00457
(Glyco_hydro_11) 		5 TRP B  78
TYR B  87
PRO B 125
TRP B 137
TYR B 170
 None
 0.72A 5tzoA-1te1B:
26.7		 5tzoA-1te1B:
45.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1te1 ENDO-1,4-XYLANASE

(Talaromyces
funiculosus) 		PF00457
(Glyco_hydro_11) 		5 TRP B  78
TYR B  87
TRP B 137
TYR B 170
GLY B 177
 None
 0.76A 5tzoA-1te1B:
26.7		 5tzoA-1te1B:
45.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ukr ENDO-1,4-B-XYLANASE
I

(Aspergillus
niger) 		PF00457
(Glyco_hydro_11) 		5 VAL A  39
TRP A  72
TYR A  81
PRO A 119
TYR A 164
 None
 0.78A 5tzoA-1ukrA:
26.3		 5tzoA-1ukrA:
40.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urj MAJOR DNA-BINDING
PROTEIN

(Human
alphaherpesvirus
1) 		PF00747
(Viral_DNA_bp) 		5 ALA A 368
TRP A 933
PRO A 925
ALA A 369
GLY A 370
 None
 1.35A 5tzoA-1urjA:
undetectable		 5tzoA-1urjA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1

(Rattus
norvegicus) 		PF00996
(GDI) 		5 VAL A 390
PRO A 606
TYR A 251
ALA A 389
GLY A 392
 None
 1.36A 5tzoA-1vg0A:
undetectable		 5tzoA-1vg0A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlj NADH-DEPENDENT
BUTANOL
DEHYDROGENASE

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		5 VAL A 190
ALA A 196
PRO A 235
ALA A 193
GLY A 192
 None
 1.27A 5tzoA-1vljA:
undetectable		 5tzoA-1vljA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1

(Pyrococcus
furiosus) 		PF00291
(PALP) 		5 PHE B  95
ALA B  86
TRP B  46
ALA B  90
GLY B  88
 None
 1.20A 5tzoA-1wdwB:
undetectable		 5tzoA-1wdwB:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9j PROBABLE BUTYRATE
KINASE 2

(Thermotoga
maritima) 		PF00871
(Acetate_kinase) 		5 SER A 106
ALA A 113
TYR A 355
ALA A 110
GLY A 109
 None
 1.02A 5tzoA-1x9jA:
undetectable		 5tzoA-1x9jA:
17.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xyn ENDO-1,4-BETA-XYLANA
SE I

(Trichoderma
reesei) 		PF00457
(Glyco_hydro_11) 		5 VAL A  35
TRP A  68
TYR A  77
PRO A 113
TYR A 158
 None
 0.84A 5tzoA-1xynA:
28.4		 5tzoA-1xynA:
43.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yna ENDO-1,4-BETA-XYLANA
SE

(Thermomyces
lanuginosus) 		PF00457
(Glyco_hydro_11) 		6 VAL A  46
TRP A  79
TYR A  88
PRO A 126
TRP A 138
TYR A 172
 None
 0.65A 5tzoA-1ynaA:
27.7		 5tzoA-1ynaA:
44.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 VAL A  13
ALA A  41
TYR A  50
ALA A  16
GLY A  15
 None
NAP  A 900 (-3.4A)
None
None
NAP  A 900 (-3.2A)
 1.30A 5tzoA-1ys4A:
undetectable		 5tzoA-1ys4A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zxo CONSERVED
HYPOTHETICAL PROTEIN
Q8A1P1

(Bacteroides
thetaiotaomicron) 		no annotation 5 VAL A 147
ALA A 195
PRO A 134
ALA A 146
GLY A 145
 None
 1.10A 5tzoA-1zxoA:
undetectable		 5tzoA-1zxoA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bcc UBIQUINOL CYTOCHROME
C OXIDOREDUCTASE

(Gallus gallus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 SER A  81
VAL A  79
ALA A 101
ALA A  84
GLY A  83
 None
 1.24A 5tzoA-2bccA:
undetectable		 5tzoA-2bccA:
16.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dck XYLANASE J

(Bacillus sp.
41M-1) 		PF00457
(Glyco_hydro_11)
PF03422
(CBM_6) 		5 TRP A  86
TYR A  95
PRO A 132
TRP A 144
GLY A 184
 None
 0.80A 5tzoA-2dckA:
25.6		 5tzoA-2dckA:
31.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran) 		5 ALA A1907
TRP A1757
TYR A1754
ALA A1908
GLY A1909
 None
 1.17A 5tzoA-2ix8A:
undetectable		 5tzoA-2ix8A:
11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lhf OUTER MEMBRANE
PROTEIN H1

(Pseudomonas
aeruginosa) 		PF13505
(OMP_b-brl) 		5 PHE A 179
VAL A   6
ALA A  57
ALA A  46
GLY A  47
 None
 1.24A 5tzoA-2lhfA:
undetectable		 5tzoA-2lhfA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvo RO SIXTY-RELATED
PROTEIN, RSR

(Deinococcus
radiodurans) 		PF05731
(TROVE) 		5 PHE A 408
VAL A 368
ALA A 426
PRO A 443
ALA A 430
 None
 1.39A 5tzoA-2nvoA:
undetectable		 5tzoA-2nvoA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6r AFUHEL308 HELICASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 ALA A 340
PRO A  48
TYR A 363
ALA A 370
GLY A 371
 None
 1.27A 5tzoA-2p6rA:
undetectable		 5tzoA-2p6rA:
13.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vul GH11 XYLANASE

(Escherichia
coli) 		PF00457
(Glyco_hydro_11) 		7 VAL A  50
TRP A  82
TYR A  91
PRO A 130
TRP A 142
TYR A 175
GLY A 182
 None
12P  A1199 ( 4.7A)
None
12P  A1199 ( 4.6A)
None
12P  A1199 (-4.2A)
None
 0.82A 5tzoA-2vulA:
28.5		 5tzoA-2vulA:
51.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 VAL A  36
ALA A  40
TYR A 315
ALA A  39
GLY A  38
 None
GOL  A1726 ( 4.0A)
None
None
None
 1.30A 5tzoA-2x40A:
undetectable		 5tzoA-2x40A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0e UDP-GLUCOSE
DEHYDROGENASE

(Burkholderia
cepacia) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 VAL A  14
ALA A  20
PRO A  45
ALA A  17
GLY A  16
 None
 1.38A 5tzoA-2y0eA:
undetectable		 5tzoA-2y0eA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 SER A2185
VAL A2138
ALA A3009
ALA A2137
GLY A2136
 None
 1.38A 5tzoA-3cmvA:
undetectable		 5tzoA-3cmvA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo sapiens) 		PF00233
(PDEase_I) 		5 SER A 561
ALA A 592
PRO A 513
TRP A 541
ALA A 593
 None
 1.38A 5tzoA-3ecnA:
undetectable		 5tzoA-3ecnA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG

(Sulfolobus
solfataricus) 		PF01890
(CbiG_C)
PF11760
(CbiG_N) 		5 SER A 254
VAL A 301
ALA A 330
ALA A 302
GLY A 219
 None
SO4  A   3 (-4.0A)
None
SO4  A   3 (-3.8A)
None
 1.21A 5tzoA-3eeqA:
undetectable		 5tzoA-3eeqA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eg4 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E

(Brucella suis) 		PF00132
(Hexapep)
PF14602
(Hexapep_2)
PF14805
(THDPS_N_2) 		5 SER A 121
ALA A 157
PRO A  94
ALA A 139
GLY A 138
 None
 1.13A 5tzoA-3eg4A:
undetectable		 5tzoA-3eg4A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw6 CELLULASE

(uncultured
bacterium) 		PF12891
(Glyco_hydro_44) 		5 SER A 476
ALA A 548
TYR A 445
ALA A 479
GLY A 478
 None
 1.10A 5tzoA-3fw6A:
undetectable		 5tzoA-3fw6A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnr OS03G0212800 PROTEIN

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		5 VAL A  66
ALA A  62
TRP A 452
ALA A  65
GLY A  34
 VAL  A  66 ( 0.6A)
ALA  A  62 ( 0.0A)
TRP  A 452 (-0.5A)
ALA  A  65 ( 0.0A)
GLY  A  34 ( 0.0A)
 1.19A 5tzoA-3gnrA:
undetectable		 5tzoA-3gnrA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I

(Gallus gallus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 SER A  81
VAL A  79
ALA A 101
ALA A  84
GLY A  83
 None
 1.14A 5tzoA-3h1lA:
undetectable		 5tzoA-3h1lA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdu PUTATIVE
THIOESTERASE

(Syntrophus
aciditrophicus) 		PF03061
(4HBT) 		5 PHE A  35
SER A  37
VAL A  41
ALA A  77
ALA A  76
 None
 1.33A 5tzoA-3hduA:
undetectable		 5tzoA-3hduA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Candida
albicans) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 PHE A  19
VAL A   8
ALA A  36
TYR A  45
GLY A  10
 None
None
NAP  A 366 (-3.4A)
None
NAP  A 366 (-3.3A)
 1.27A 5tzoA-3hskA:
undetectable		 5tzoA-3hskA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l47 ODORANT BINDING
PROTEIN
(AGAP010409-PA)

(Anopheles
gambiae) 		PF01395
(PBP_GOBP) 		5 VAL A  36
ALA A  40
TYR A  48
ALA A  39
GLY A  38
 None
 1.33A 5tzoA-3l47A:
undetectable		 5tzoA-3l47A:
19.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lb9 ENDO-1,4-BETA-XYLANA
SE

(Bacillus
circulans) 		PF00457
(Glyco_hydro_11) 		7 VAL A 102
TRP A 136
TYR A 145
PRO A 181
TRP A   8
TYR A  45
GLY A  52
 None
 0.82A 5tzoA-3lb9A:
12.4		 5tzoA-3lb9A:
60.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3m4f ENDO-1,4-BETA-XYLANA
SE

(Acidomyces
acidophilus) 		PF00457
(Glyco_hydro_11) 		5 VAL A  62
TRP A  95
TYR A 104
PRO A 142
TRP A 154
 None
None
None
CXS  A 206 ( 4.3A)
None
 0.81A 5tzoA-3m4fA:
26.8		 5tzoA-3m4fA:
39.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mf9 ENDO-1,4-BETA-XYLANA
SE

(Thermopolyspora
flexuosa) 		PF00457
(Glyco_hydro_11) 		6 VAL A  49
TRP A  81
PRO A 126
TRP A 138
TYR A 171
GLY A 178
 None
 0.75A 5tzoA-3mf9A:
28.0		 5tzoA-3mf9A:
56.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqh GLYCOSYL HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF04616
(Glyco_hydro_43) 		5 PHE A 414
SER A 399
VAL A 401
PRO A 417
ALA A 292
 None
 1.35A 5tzoA-3nqhA:
undetectable		 5tzoA-3nqhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phf ENVELOPE
GLYCOPROTEIN H

(Human
gammaherpesvirus
4) 		no annotation 5 SER A 195
VAL A 197
ALA A 172
TYR A 213
GLY A 180
 None
 1.19A 5tzoA-3phfA:
undetectable		 5tzoA-3phfA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r8y 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-ACETYLTRANSFERASE

(Bacillus
anthracis) 		PF00132
(Hexapep)
PF08503
(DapH_N)
PF14602
(Hexapep_2) 		5 VAL A 104
ALA A 140
PRO A  83
ALA A 122
GLY A 121
 None
 0.95A 5tzoA-3r8yA:
undetectable		 5tzoA-3r8yA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE

(Pyrococcus
horikoshii) 		no annotation 5 ALA A 306
PRO A  56
TYR A 292
ALA A 303
GLY A 302
 None
ACY  A 338 ( 4.7A)
None
None
None
 1.15A 5tzoA-3u4gA:
undetectable		 5tzoA-3u4gA:
19.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vzm ENDO-1,4-BETA-XYLANA
SE

(Bacillus
circulans) 		PF00457
(Glyco_hydro_11) 		7 VAL A  37
TRP A  71
TYR A  80
PRO A 116
TRP A 129
TYR A 166
GLY A 173
 XYP  A 202 (-4.9A)
XYP  A 202 ( 4.9A)
None
DFX  A 201 (-3.9A)
None
XYP  A 202 (-4.7A)
None
 0.48A 5tzoA-3vzmA:
35.1		 5tzoA-3vzmA:
91.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbm COPPER-CONTAINING
NITRITE REDUCTASE

(Ralstonia
pickettii) 		PF07732
(Cu-oxidase_3)
PF13442
(Cytochrome_CBB3) 		5 PHE A 174
VAL A 201
ALA A 294
ALA A 299
GLY A 298
 None
 1.37A 5tzoA-3zbmA:
undetectable		 5tzoA-3zbmA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Mycobacterium
tuberculosis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 VAL A 281
ALA A 285
PRO A  36
ALA A 284
GLY A 283
 None
 1.12A 5tzoA-3zhyA:
undetectable		 5tzoA-3zhyA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zse ENDO-1,4-BETA-XYLANA
SE

(Thermobifida
fusca) 		PF00457
(Glyco_hydro_11) 		7 VAL A  88
TRP A 120
TYR A 129
PRO A 165
TRP A 177
TYR A 210
GLY A 217
 FXP  A1207 (-4.7A)
FXP  A1207 (-4.6A)
None
FXP  A1207 (-3.7A)
None
FXP  A1207 (-4.7A)
None
 0.78A 5tzoA-3zseA:
28.4		 5tzoA-3zseA:
55.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a63 APOPTOSIS
STIMULATING OF P53
PROTEIN 2

(Homo sapiens) 		PF00018
(SH3_1)
PF12796
(Ank_2) 		5 PHE B1010
SER B1014
ALA B1017
ALA B1016
GLY B1015
 None
 1.23A 5tzoA-4a63B:
undetectable		 5tzoA-4a63B:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a63 APOPTOSIS
STIMULATING OF P53
PROTEIN 2

(Homo sapiens) 		PF00018
(SH3_1)
PF12796
(Ank_2) 		5 SER B1014
VAL B1012
ALA B1017
ALA B1016
GLY B1015
 None
 1.37A 5tzoA-4a63B:
undetectable		 5tzoA-4a63B:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aty TEREPHTHALATE
1,2-CIS-DIHYDRODIOL
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF04166
(PdxA) 		5 VAL A 124
ALA A 130
PRO A  27
TYR A 159
ALA A 127
 None
 1.35A 5tzoA-4atyA:
undetectable		 5tzoA-4atyA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bb9 GLUCOKINASE
REGULATORY PROTEIN

(Homo sapiens) 		no annotation 5 VAL A  90
ALA A 287
TYR A 134
ALA A  87
GLY A  88
 None
 1.37A 5tzoA-4bb9A:
undetectable		 5tzoA-4bb9A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7e L-LYS MONOOXYGENASE

(Nocardia
farcinica) 		PF13434
(K_oxygenase) 		5 SER A 237
VAL A 280
ALA A 334
ALA A 218
GLY A 213
 None
 1.31A 5tzoA-4d7eA:
undetectable		 5tzoA-4d7eA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL

(Homo sapiens) 		PF00481
(PP2C) 		5 PHE A 292
VAL A 343
ALA A  98
ALA A 323
GLY A  96
 None
None
None
None
BME  A 501 ( 4.5A)
 1.39A 5tzoA-4da1A:
undetectable		 5tzoA-4da1A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exb PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF00248
(Aldo_ket_red) 		5 PHE A 108
SER A 136
VAL A 134
ALA A 185
GLY A 169
 None
 1.33A 5tzoA-4exbA:
undetectable		 5tzoA-4exbA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0t C-PHYCOCYANIN ALPHA
CHAIN

(Synechocystis
sp. PCC 6803) 		PF00502
(Phycobilisome) 		5 SER A  50
VAL A  52
ALA A  58
ALA A  55
GLY A  54
 None
 1.37A 5tzoA-4f0tA:
undetectable		 5tzoA-4f0tA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE

(Homo sapiens) 		PF00884
(Sulfatase)
PF14707
(Sulfatase_C) 		5 SER A 287
ALA A 292
TYR A 254
ALA A 291
GLY A 290
 None
 1.39A 5tzoA-4fdjA:
undetectable		 5tzoA-4fdjA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU

(Yersinia pestis) 		PF01032
(FecCD) 		5 SER A 118
ALA A  96
TRP A 181
ALA A 123
GLY A 122
 None
 1.30A 5tzoA-4g1uA:
undetectable		 5tzoA-4g1uA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		5 SER M 267
ALA M 296
PRO M 209
ALA M 297
GLY M 294
 None
 1.33A 5tzoA-4heaM:
undetectable		 5tzoA-4heaM:
18.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hk9 ENDO-1,4-BETA-XYLANA
SE 2

(Trichoderma
reesei) 		PF00457
(Glyco_hydro_11) 		7 VAL A  46
TRP A  79
TYR A  88
PRO A 126
TRP A 138
TYR A 171
GLY A 178
 XYP  A 202 (-4.9A)
XYP  A 202 (-4.7A)
None
XYP  A 203 ( 4.0A)
None
XYP  A 202 (-4.7A)
None
 0.72A 5tzoA-4hk9A:
29.2		 5tzoA-4hk9A:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8q PUTATIVE
UNCHARACTERIZED
PROTEIN

(Bacteroides
fragilis) 		PF12667
(NigD_N)
PF17415
(NigD_C) 		5 VAL A  76
TRP A  55
ALA A  52
TYR A  68
ALA A  38
 None
 1.36A 5tzoA-4j8qA:
undetectable		 5tzoA-4j8qA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis) 		PF00532
(Peripla_BP_1) 		5 PHE A 279
VAL A 243
ALA A 216
ALA A 242
GLY A 241
 None
 1.27A 5tzoA-4kzkA:
undetectable		 5tzoA-4kzkA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npl RNA DEMETHYLASE
ALKBH5

(Danio rerio) 		PF13532
(2OG-FeII_Oxy_2) 		5 SER A  18
VAL A  16
ALA A 192
ALA A 191
GLY A  19
 None
 1.34A 5tzoA-4nplA:
undetectable		 5tzoA-4nplA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nrq RNA DEMETHYLASE
ALKBH5

(Homo sapiens) 		PF13532
(2OG-FeII_Oxy_2) 		5 SER A  87
VAL A  85
ALA A 261
ALA A 260
GLY A  88
 None
 1.35A 5tzoA-4nrqA:
undetectable		 5tzoA-4nrqA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nt9 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		no annotation 5 VAL B 211
ALA B 183
TYR B 229
ALA B 215
GLY B 186
 None
 1.39A 5tzoA-4nt9B:
undetectable		 5tzoA-4nt9B:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4osp OXYGENASE-REDUCTASE

(Streptomyces
fradiae) 		PF13561
(adh_short_C2) 		5 SER A 213
VAL A 218
ALA A 207
ALA A 210
GLY A 211
 None
 1.32A 5tzoA-4ospA:
undetectable		 5tzoA-4ospA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovt TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Ochrobactrum
anthropi) 		PF03480
(DctP) 		5 SER A 267
ALA A 260
PRO A  39
ALA A 263
GLY A 264
 None
 1.30A 5tzoA-4ovtA:
undetectable		 5tzoA-4ovtA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2f ADENYLATE CYCLASE

(Mycobacterium
tuberculosis) 		PF00211
(Guanylate_cyc) 		5 VAL A 352
ALA A 348
PRO A 311
ALA A 370
GLY A 350
 None
 1.28A 5tzoA-4p2fA:
undetectable		 5tzoA-4p2fA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pka PATATIN-17

(Solanum
cardiophyllum) 		PF01734
(Patatin) 		5 VAL X 218
ALA X 222
PRO X 196
ALA X 217
GLY X 216
 None
 1.33A 5tzoA-4pkaX:
undetectable		 5tzoA-4pkaX:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s38 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF04551
(GcpE) 		5 VAL A 340
ALA A 354
PRO A 361
ALA A 339
GLY A 357
 None
 1.29A 5tzoA-4s38A:
undetectable		 5tzoA-4s38A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoz BETA-GALACTOSIDASE

(Bifidobacterium
animalis) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		5 PHE A 449
SER A 309
ALA A 466
TYR A 471
GLY A 313
 None
 1.25A 5tzoA-4uozA:
undetectable		 5tzoA-4uozA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v08 UL26

(Suid
alphaherpesvirus
1) 		PF00716
(Peptidase_S21) 		5 SER A   7
VAL A 143
ALA A 215
PRO A 148
GLY A   8
 None
 1.38A 5tzoA-4v08A:
undetectable		 5tzoA-4v08A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpu ENDONUCLEASE V

(Escherichia
coli) 		PF04493
(Endonuclease_5) 		5 VAL A 102
ALA A  48
PRO A 126
ALA A  34
GLY A  33
 None
 1.17A 5tzoA-4xpuA:
undetectable		 5tzoA-4xpuA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1k OUTER MEMBRANE
PROTEIN OPRM

(Pseudomonas
aeruginosa) 		PF02321
(OEP) 		5 PHE A 379
SER A 438
ALA A 370
ALA A 374
GLY A 372
 None
 1.15A 5tzoA-4y1kA:
undetectable		 5tzoA-4y1kA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjf D-AMINO-ACID OXIDASE

(Sus scrofa) 		PF01266
(DAO) 		5 PHE B 213
ALA B  48
TYR B 224
ALA B  49
GLY B  50
 None
FAD  B 401 (-3.6A)
98B  B 404 (-3.3A)
FAD  B 401 (-3.2A)
FAD  B 401 (-3.9A)
 1.25A 5tzoA-4yjfB:
undetectable		 5tzoA-4yjfB:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 PHE A 181
SER A 183
VAL A 206
TRP A 482
ALA A 188
 None
None
None
1PE  A 803 ( 4.0A)
None
 1.35A 5tzoA-4zohA:
undetectable		 5tzoA-4zohA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwa TYPE-2 RESTRICTION
ENZYME AGEI

(Thalassobius
gelatinovorus) 		no annotation 5 ALA A  46
PRO A  63
TRP A  88
ALA A  50
GLY A  48
 None
 1.33A 5tzoA-5dwaA:
undetectable		 5tzoA-5dwaA:
21.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ej3 ENDO-1,4-BETA-XYLANA
SE B

(Streptomyces
lividans) 		PF00457
(Glyco_hydro_11) 		6 VAL A  48
TRP A  80
TYR A  89
PRO A 125
TRP A 137
TYR A 171
 None
 0.75A 5tzoA-5ej3A:
27.5		 5tzoA-5ej3A:
49.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ej3 ENDO-1,4-BETA-XYLANA
SE B

(Streptomyces
lividans) 		PF00457
(Glyco_hydro_11) 		6 VAL A  48
TRP A  80
TYR A  89
TRP A 137
TYR A 171
GLY A 178
 None
 0.81A 5tzoA-5ej3A:
27.5		 5tzoA-5ej3A:
49.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h36 UNCHARACTERIZED
PROTEIN TRIC

(Rhodobacter
sphaeroides) 		no annotation 5 PHE E 163
VAL E 105
ALA E 129
ALA E 104
GLY E 125
 None
 1.35A 5tzoA-5h36E:
undetectable		 5tzoA-5h36E:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hos CELLULASE

(Xanthomonas
citri) 		PF00150
(Cellulase) 		5 SER A 281
ALA A 316
TRP A 277
ALA A  10
GLY A  11
 None
 1.40A 5tzoA-5hosA:
undetectable		 5tzoA-5hosA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxs SODIUM,CALCIUM
EXCHANGER

(Methanocaldococcus
jannaschii) 		PF01699
(Na_Ca_ex) 		5 ALA A  47
TRP A 141
TYR A 138
ALA A  43
GLY A 231
 None
 1.19A 5tzoA-5hxsA:
undetectable		 5tzoA-5hxsA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j78 ACETALDEHYDE
DEHYDROGENASE
(ACETYLATING)

(Parageobacillus
thermoglucosidasius) 		PF00171
(Aldedh) 		5 SER A 164
VAL A 162
PRO A 200
ALA A 135
GLY A 136
 None
 1.39A 5tzoA-5j78A:
undetectable		 5tzoA-5j78A:
16.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jrm ENDO-1,4-BETA-XYLANA
SE

(Fusarium
oxysporum) 		PF00457
(Glyco_hydro_11) 		5 TRP A  78
TYR A  87
PRO A 125
TRP A 137
TYR A 170
 GOL  A 201 ( 3.7A)
None
GOL  A 201 (-4.1A)
None
None
 0.51A 5tzoA-5jrmA:
27.6		 5tzoA-5jrmA:
47.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jrm ENDO-1,4-BETA-XYLANA
SE

(Fusarium
oxysporum) 		PF00457
(Glyco_hydro_11) 		5 VAL A  46
TRP A  78
TYR A  87
PRO A 125
TRP A 137
 GOL  A 201 ( 4.7A)
GOL  A 201 ( 3.7A)
None
GOL  A 201 (-4.1A)
None
 0.78A 5tzoA-5jrmA:
27.6		 5tzoA-5jrmA:
47.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jw6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Aspergillus
fumigatus) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 VAL A  11
ALA A  39
TYR A  48
ALA A  14
GLY A  13
 None
SO4  A 402 (-3.1A)
None
None
None
 1.31A 5tzoA-5jw6A:
undetectable		 5tzoA-5jw6A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nmi CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL

(Bos taurus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 SER A  81
VAL A  79
ALA A 101
ALA A  84
GLY A  83
 None
 1.31A 5tzoA-5nmiA:
undetectable		 5tzoA-5nmiA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyn DEHYDRATASE,
ILVD/EDD FAMILY

(Caulobacter
vibrioides) 		no annotation 5 SER A 398
ALA A 303
PRO A 314
ALA A 272
GLY A 381
 None
 1.32A 5tzoA-5oynA:
undetectable		 5tzoA-5oynA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr1 CHLORIDE CHANNEL
PROTEIN

(Bos taurus) 		PF00654
(Voltage_CLC) 		5 VAL A 478
ALA A 508
PRO A 428
ALA A 477
GLY A 476
 None
 1.12A 5tzoA-5tr1A:
undetectable		 5tzoA-5tr1A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqj EXO-BETA-1,4-XYLANAS
E

(unidentified) 		no annotation 5 TRP A  82
TYR A 100
PRO A 137
TRP A 149
TYR A 194
 None
 0.38A 5tzoA-5vqjA:
24.0		 5tzoA-5vqjA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqj EXO-BETA-1,4-XYLANAS
E

(unidentified) 		no annotation 5 VAL A  50
TRP A  82
TYR A 100
PRO A 137
TRP A 149
 None
 0.67A 5tzoA-5vqjA:
24.0		 5tzoA-5vqjA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgm RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Bacillus
subtilis) 		no annotation 5 SER A 246
ALA A 249
TYR A 357
ALA A 248
GLY A 247
 None
 1.21A 5tzoA-6cgmA:
undetectable		 5tzoA-6cgmA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT

(Methylomicrobium
alcaliphilum) 		no annotation 5 SER A 113
TRP B  54
PRO B 194
ALA A 266
GLY A 267
 None
 1.08A 5tzoA-6cxhA:
undetectable		 5tzoA-6cxhA:
19.19