SIMILAR PATTERNS OF AMINO ACIDS FOR 5TZO_A_7V7A201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1axk GLUXYN-1

(Bacillus
subtilis)
PF00457
(Glyco_hydro_11)
PF00722
(Glyco_hydro_16)
4 THR A 247
THR A 266
ARG A 268
GLN A 283
None
0.95A 5tzoA-1axkA:
34.6
5tzoA-1axkA:
58.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1axk GLUXYN-1

(Bacillus
subtilis)
PF00457
(Glyco_hydro_11)
PF00722
(Glyco_hydro_16)
5 TYR A 264
THR A 266
ARG A 268
GLN A 283
TRP A 285
None
0.53A 5tzoA-1axkA:
34.6
5tzoA-1axkA:
58.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1f5j BETA-1,4-XYLANASE

(Dictyoglomus
thermophilum)
PF00457
(Glyco_hydro_11)
5 TYR A 121
THR A 123
ARG A 125
GLN A 139
TRP A 141
None
0.94A 5tzoA-1f5jA:
25.4
5tzoA-1f5jA:
42.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h1a ENDO-1,4-BETA-XYLANA
SE


(Chaetomium
thermophilum)
PF00457
(Glyco_hydro_11)
5 THR A 101
TYR A 119
THR A 121
GLN A 137
TRP A 139
None
0.90A 5tzoA-1h1aA:
28.8
5tzoA-1h1aA:
52.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h1a ENDO-1,4-BETA-XYLANA
SE


(Chaetomium
thermophilum)
PF00457
(Glyco_hydro_11)
5 TYR A 119
THR A 121
ARG A 123
GLN A 137
TRP A 139
None
None
GOL  A1196 (-2.8A)
None
None
1.28A 5tzoA-1h1aA:
28.8
5tzoA-1h1aA:
52.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hix ENDO-1,4-BETA-XYLANA
SE


(Streptomyces
sp. S38)
PF00457
(Glyco_hydro_11)
5 TYR A 117
THR A 119
ARG A 121
GLN A 135
TRP A 137
None
0.48A 5tzoA-1hixA:
27.6
5tzoA-1hixA:
54.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1igo FAMILY 11 XYLANASE

(Bacillus
subtilis)
PF00457
(Glyco_hydro_11)
4 THR A 107
THR A 126
ARG A 128
GLN A 142
None
1.06A 5tzoA-1igoA:
25.2
5tzoA-1igoA:
48.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1igo FAMILY 11 XYLANASE

(Bacillus
subtilis)
PF00457
(Glyco_hydro_11)
5 TYR A 124
THR A 126
ARG A 128
GLN A 142
TRP A 144
None
0.73A 5tzoA-1igoA:
25.2
5tzoA-1igoA:
48.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1imv PIGMENT
EPITHELIUM-DERIVED
FACTOR


(Homo sapiens)
PF00079
(Serpin)
4 THR A  67
TYR A 142
THR A 144
ARG A 121
None
1.29A 5tzoA-1imvA:
undetectable
5tzoA-1imvA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyn CHLOROPLASTIC
ASCORBATE PEROXIDASE


(Nicotiana
tabacum)
PF00141
(peroxidase)
4 THR A 164
TYR A 206
ARG A 167
TRP A 195
NA  A 297 (-3.2A)
None
None
None
1.39A 5tzoA-1iynA:
undetectable
5tzoA-1iynA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum)
PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ)
4 THR A 209
THR A 985
ARG A 913
GLN A1047
None
1.08A 5tzoA-1k32A:
undetectable
5tzoA-1k32A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum)
PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ)
4 TRP A 214
THR A 985
ARG A 913
GLN A1047
None
1.32A 5tzoA-1k32A:
undetectable
5tzoA-1k32A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqj A/G-SPECIFIC ADENINE
GLYCOSYLASE


(Escherichia
coli)
PF00633
(HHH)
PF00730
(HhH-GPD)
4 TRP A  77
THR A  78
TYR A  51
ARG A  58
None
None
None
GOL  A 302 (-2.9A)
1.36A 5tzoA-1kqjA:
undetectable
5tzoA-1kqjA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ks5 ENDOGLUCANASE A

(Aspergillus
niger)
PF01670
(Glyco_hydro_12)
4 TRP A  45
THR A 203
TYR A  61
GLN A  19
None
1.02A 5tzoA-1ks5A:
16.6
5tzoA-1ks5A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tr7 FIMH PROTEIN

(Escherichia
coli)
no annotation 4 TRP B 103
THR B  57
TYR B  77
ARG B  60
None
1.01A 5tzoA-1tr7B:
undetectable
5tzoA-1tr7B:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u69 HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa)
PF06983
(3-dmu-9_3-mt)
4 THR A 119
THR A  88
ARG A 147
GLN A  85
None
1.25A 5tzoA-1u69A:
undetectable
5tzoA-1u69A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u9c APC35852

(Geobacillus
stearothermophilus)
PF01965
(DJ-1_PfpI)
4 THR A 148
THR A 150
ARG A 183
GLN A 201
None
1.37A 5tzoA-1u9cA:
undetectable
5tzoA-1u9cA:
20.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yna ENDO-1,4-BETA-XYLANA
SE


(Thermomyces
lanuginosus)
PF00457
(Glyco_hydro_11)
4 THR A 120
ARG A 122
GLN A 136
TRP A 138
None
0.44A 5tzoA-1ynaA:
27.7
5tzoA-1ynaA:
44.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3i SIMILAR TO
RAD54-LIKE


(Danio rerio)
PF00176
(SNF2_N)
PF00271
(Helicase_C)
4 THR X 618
THR X 669
ARG X 672
GLN X 627
None
1.41A 5tzoA-1z3iX:
undetectable
5tzoA-1z3iX:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlp PETAL DEATH PROTEIN

(Dianthus
caryophyllus)
PF13714
(PEP_mutase)
4 THR A 180
TYR A 198
THR A 206
ARG A 228
None
1.28A 5tzoA-1zlpA:
undetectable
5tzoA-1zlpA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0j GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 2


(Homo sapiens)
PF03360
(Glyco_transf_43)
4 THR A 189
TYR A 190
THR A 104
GLN A 107
None
1.16A 5tzoA-2d0jA:
undetectable
5tzoA-2d0jA:
19.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f6b FAMILY 11 XYLANASE

(Bacillus)
PF00457
(Glyco_hydro_11)
5 TYR A 125
THR A 127
ARG A 129
GLN A 143
TRP A 145
None
0.59A 5tzoA-2f6bA:
25.1
5tzoA-2f6bA:
47.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gvk HEME PEROXIDASE

(Bacteroides
thetaiotaomicron)
PF04261
(Dyp_perox)
4 THR A 268
TYR A 186
THR A 272
ARG A 245
None
None
None
EDO  A 323 (-4.0A)
1.39A 5tzoA-2gvkA:
undetectable
5tzoA-2gvkA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT


(Aromatoleum
aromaticum)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
4 TRP A 471
THR A 231
THR A 807
ARG A 811
None
1.32A 5tzoA-2ivfA:
undetectable
5tzoA-2ivfA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j89 METHIONINE SULFOXIDE
REDUCTASE A


(Populus
trichocarpa)
PF01625
(PMSR)
4 THR A 137
TYR A 135
ARG A  92
GLN A  41
None
1.24A 5tzoA-2j89A:
undetectable
5tzoA-2j89A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lpu KMATG10

(Kluyveromyces
marxianus)
PF03987
(Autophagy_act_C)
4 TRP A  21
THR A  19
ARG A  26
GLN A  35
None
1.32A 5tzoA-2lpuA:
undetectable
5tzoA-2lpuA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA


(Desulfovibrio
vulgaris)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
4 TRP B  41
TYR B  63
THR B  64
ARG B  94
None
None
None
SH0  A 503 (-2.7A)
1.33A 5tzoA-2v4jB:
undetectable
5tzoA-2v4jB:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vcl CYANOBACTERIAL
PHYCOERYTHROBILIN


(Prochlorococcus
phage P-SSM2)
PF05996
(Fe_bilin_red)
4 TRP A  47
THR A  62
ARG A  75
TRP A  44
None
1.19A 5tzoA-2vclA:
undetectable
5tzoA-2vclA:
20.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vul GH11 XYLANASE

(Escherichia
coli)
PF00457
(Glyco_hydro_11)
4 TYR A 122
ARG A 126
GLN A 140
TRP A 142
None
0.67A 5tzoA-2vulA:
28.5
5tzoA-2vulA:
51.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vzx GREEN FLUORESCENT
PROTEIN


(Dendronephthya
sp. SSAL-2002)
PF01353
(GFP)
4 THR A 176
TYR A 177
ARG A 104
TRP A  89
None
None
None
CR8  A  64 ( 3.8A)
1.08A 5tzoA-2vzxA:
undetectable
5tzoA-2vzxA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL


(Homo sapiens)
PF00155
(Aminotran_1_2)
4 THR A  99
THR A 275
ARG A 257
GLN A  91
None
1.30A 5tzoA-2xh1A:
undetectable
5tzoA-2xh1A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsj SULFITE REDUCTASE
BETA SUBUNIT


(Desulfomicrobium
norvegicum)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
PF12838
(Fer4_7)
4 TRP B  41
TYR B  63
THR B  64
ARG B  94
None
None
None
SRM  A 503 (-2.7A)
1.38A 5tzoA-2xsjB:
undetectable
5tzoA-2xsjB:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybr SINGLE CHAIN
ANTIBODY FRAGMENT
9004G


(Homo sapiens)
PF07686
(V-set)
4 TRP A 107
TYR B 219
ARG B 228
GLN B 221
None
1.17A 5tzoA-2ybrA:
undetectable
5tzoA-2ybrA:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2u UPF0026 PROTEIN
MJ0257


(Methanocaldococcus
jannaschii)
PF04055
(Radical_SAM)
PF08608
(Wyosine_form)
4 TRP A  61
TRP A  89
TYR A 142
THR A  56
None
1.28A 5tzoA-2z2uA:
undetectable
5tzoA-2z2uA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahy BETA-GLUCOSIDASE

(Trichoderma
reesei)
PF00232
(Glyco_hydro_1)
4 THR A 370
TYR A 298
THR A 299
ARG A 341
None
TRS  A 500 (-4.1A)
None
None
1.27A 5tzoA-3ahyA:
undetectable
5tzoA-3ahyA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvd PLASTOCYANIN

(Phormidium
laminosum)
PF00127
(Copper-bind)
4 THR A 102
TYR A  85
THR A  86
GLN A  47
None
1.19A 5tzoA-3cvdA:
undetectable
5tzoA-3cvdA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djl PROTEIN AIDB

(Escherichia
coli)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
4 THR A 298
THR A 378
ARG A 375
TRP A 362
None
1.38A 5tzoA-3djlA:
undetectable
5tzoA-3djlA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dnf 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE


(Aquifex
aeolicus)
PF02401
(LYTB)
4 THR A 166
THR A 196
ARG A 226
GLN A 200
None
1.40A 5tzoA-3dnfA:
undetectable
5tzoA-3dnfA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE


(Enterococcus
faecium)
PF01636
(APH)
4 TYR A  95
THR A  94
ARG A  92
GLN A  97
None
1.41A 5tzoA-3hamA:
undetectable
5tzoA-3hamA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT


(Eubacterium
barkeri)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
4 TYR A 176
THR A 178
ARG A 278
GLN A 357
None
None
NO3  A5658 (-4.0A)
NO3  A5658 (-3.1A)
1.15A 5tzoA-3hrdA:
undetectable
5tzoA-3hrdA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if2 AMINOTRANSFERASE

(Psychrobacter
arcticus)
PF00155
(Aminotran_1_2)
4 THR A 151
THR A 218
ARG A 415
TRP A 368
None
1.32A 5tzoA-3if2A:
undetectable
5tzoA-3if2A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv1 P22 PROTEIN

(Trypanosoma
brucei)
PF02330
(MAM33)
4 TRP A  79
THR A  80
THR A  91
GLN A 104
None
1.36A 5tzoA-3jv1A:
undetectable
5tzoA-3jv1A:
19.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lb9 ENDO-1,4-BETA-XYLANA
SE


(Bacillus
circulans)
PF00457
(Glyco_hydro_11)
4 THR A 156
THR A 175
ARG A 177
GLN A   6
None
0.87A 5tzoA-3lb9A:
12.4
5tzoA-3lb9A:
60.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lb9 ENDO-1,4-BETA-XYLANA
SE


(Bacillus
circulans)
PF00457
(Glyco_hydro_11)
5 TYR A 173
THR A 175
ARG A 177
GLN A   6
TRP A   8
None
0.59A 5tzoA-3lb9A:
12.4
5tzoA-3lb9A:
60.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mf9 ENDO-1,4-BETA-XYLANA
SE


(Thermopolyspora
flexuosa)
PF00457
(Glyco_hydro_11)
4 THR A 101
THR A 120
ARG A 122
GLN A 136
None
1.03A 5tzoA-3mf9A:
28.0
5tzoA-3mf9A:
56.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mf9 ENDO-1,4-BETA-XYLANA
SE


(Thermopolyspora
flexuosa)
PF00457
(Glyco_hydro_11)
5 TYR A 118
THR A 120
ARG A 122
GLN A 136
TRP A 138
None
0.72A 5tzoA-3mf9A:
28.0
5tzoA-3mf9A:
56.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mw3 NEUREXIN-2-BETA

(Rattus
norvegicus)
PF02210
(Laminin_G_2)
4 TRP A 102
THR A 101
TYR A 100
ARG A 130
None
1.05A 5tzoA-3mw3A:
undetectable
5tzoA-3mw3A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mw4 NEUREXIN-2-BETA

(Mus musculus)
PF02210
(Laminin_G_2)
4 TRP A  98
THR A  97
TYR A  96
ARG A 126
None
1.08A 5tzoA-3mw4A:
undetectable
5tzoA-3mw4A:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qv9 PYRUVATE KINASE 2

(Trypanosoma
cruzi)
PF00224
(PK)
PF02887
(PK_C)
4 THR A 424
THR A 428
ARG A 427
GLN A 431
None
1.37A 5tzoA-3qv9A:
undetectable
5tzoA-3qv9A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxb PUTATIVE XYLOSE
ISOMERASE


(Rhodospirillum
rubrum)
PF01261
(AP_endonuc_2)
4 THR A  36
TYR A  37
THR A  40
ARG A  52
None
None
None
EDO  A 360 ( 3.2A)
1.39A 5tzoA-3qxbA:
undetectable
5tzoA-3qxbA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9r PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE


(Mycobacteroides
abscessus)
PF01259
(SAICAR_synt)
4 THR A 181
TYR A 180
THR A 176
ARG A 173
THR  A 181 ( 0.8A)
TYR  A 180 ( 1.3A)
THR  A 176 ( 0.8A)
ARG  A 173 ( 0.6A)
1.40A 5tzoA-3r9rA:
undetectable
5tzoA-3r9rA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0a NTNH

(Clostridium
botulinum)
PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C)
4 TRP B 561
THR B 727
THR B 899
ARG B 563
None
1.38A 5tzoA-3v0aB:
undetectable
5tzoA-3v0aB:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4v INTEGRIN BETA-7

(Homo sapiens)
PF00362
(Integrin_beta)
4 THR B 419
ARG B 124
GLN B 122
TRP B 421
None
1.37A 5tzoA-3v4vB:
undetectable
5tzoA-3v4vB:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vta CUCUMISIN

(Cucumis melo)
PF00082
(Peptidase_S8)
4 TRP A 246
THR A 141
THR A 201
ARG A 199
None
1.39A 5tzoA-3vtaA:
undetectable
5tzoA-3vtaA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vz0 PUTATIVE
NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE


(Gluconobacter
oxydans)
PF00171
(Aldedh)
4 THR A  13
THR A   6
ARG A  16
GLN A 163
None
1.23A 5tzoA-3vz0A:
undetectable
5tzoA-3vz0A:
17.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vzm ENDO-1,4-BETA-XYLANA
SE


(Bacillus
circulans)
PF00457
(Glyco_hydro_11)
4 THR A  91
THR A 110
ARG A 112
GLN A 127
None
None
DFX  A 201 (-3.9A)
DFX  A 201 (-4.3A)
0.82A 5tzoA-3vzmA:
35.1
5tzoA-3vzmA:
91.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vzm ENDO-1,4-BETA-XYLANA
SE


(Bacillus
circulans)
PF00457
(Glyco_hydro_11)
5 TYR A 108
THR A 110
ARG A 112
GLN A 127
TRP A 129
None
None
DFX  A 201 (-3.9A)
DFX  A 201 (-4.3A)
None
0.46A 5tzoA-3vzmA:
35.1
5tzoA-3vzmA:
91.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zse ENDO-1,4-BETA-XYLANA
SE


(Thermobifida
fusca)
PF00457
(Glyco_hydro_11)
4 THR A 140
THR A 159
ARG A 161
GLN A 175
None
None
FXP  A1207 (-4.1A)
FXP  A1207 (-4.3A)
0.78A 5tzoA-3zseA:
28.4
5tzoA-3zseA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zse ENDO-1,4-BETA-XYLANA
SE


(Thermobifida
fusca)
PF00457
(Glyco_hydro_11)
5 TYR A 157
THR A 159
ARG A 161
GLN A 175
TRP A 177
None
None
FXP  A1207 (-4.1A)
FXP  A1207 (-4.3A)
None
0.48A 5tzoA-3zseA:
28.4
5tzoA-3zseA:
55.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvu BETA-MANNOSIDASE

(Trichoderma
harzianum)
PF00703
(Glyco_hydro_2)
4 TRP A  87
THR A  88
TYR A  89
THR A  39
None
1.41A 5tzoA-4cvuA:
2.8
5tzoA-4cvuA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e5t MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME, C-TERMINAL
DOMAIN PROTEIN


(Labrenzia
alexandrii)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 THR A  83
TYR A  78
ARG A  60
GLN A  61
None
1.32A 5tzoA-4e5tA:
undetectable
5tzoA-4e5tA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4frx ANAEROBICALLY-INDUCE
D OUTER MEMBRANE
PORIN OPRE


(Pseudomonas
aeruginosa)
PF03573
(OprD)
4 THR A 145
THR A 143
ARG A 114
GLN A 141
None
1.24A 5tzoA-4frxA:
undetectable
5tzoA-4frxA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4frx ANAEROBICALLY-INDUCE
D OUTER MEMBRANE
PORIN OPRE


(Pseudomonas
aeruginosa)
PF03573
(OprD)
4 THR A 151
THR A 143
ARG A 114
GLN A 141
None
1.37A 5tzoA-4frxA:
undetectable
5tzoA-4frxA:
19.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hk9 ENDO-1,4-BETA-XYLANA
SE 2


(Trichoderma
reesei)
PF00457
(Glyco_hydro_11)
6 THR A 100
TYR A 118
THR A 120
ARG A 122
GLN A 136
TRP A 138
None
None
None
XYP  A 203 (-3.7A)
XYP  A 203 (-4.0A)
None
0.94A 5tzoA-4hk9A:
29.2
5tzoA-4hk9A:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ixl XYLANASE

(Bacillus sp.
(in: Bacteria))
PF00457
(Glyco_hydro_11)
4 TYR A 124
ARG A 128
GLN A 142
TRP A 144
None
0.90A 5tzoA-4ixlA:
24.6
5tzoA-4ixlA:
41.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ixl XYLANASE

(Bacillus sp.
(in: Bacteria))
PF00457
(Glyco_hydro_11)
4 TYR A 124
THR A 126
GLN A 142
TRP A 144
None
0.64A 5tzoA-4ixlA:
24.6
5tzoA-4ixlA:
41.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5r OXYGENASE

(Streptomyces
argillaceus)
PF01494
(FAD_binding_3)
4 THR A 105
THR A  60
ARG A  59
GLN A 310
None
1.27A 5tzoA-4k5rA:
undetectable
5tzoA-4k5rA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7w HD DOMAIN-CONTAINING
PROTEIN 2


(Homo sapiens)
PF13023
(HD_3)
4 TRP A  35
TYR A 168
THR A 171
GLN A 144
None
1.41A 5tzoA-4l7wA:
undetectable
5tzoA-4l7wA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdp BETA-GLUCOSIDASE

(Humicola grisea)
PF00232
(Glyco_hydro_1)
4 THR A 380
TYR A 308
THR A 309
ARG A 351
None
GOL  A 507 (-4.1A)
None
None
1.15A 5tzoA-4mdpA:
undetectable
5tzoA-4mdpA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pgj HUMAN HEAVY CHAIN
DOMAIN ANTIBODY


(Homo sapiens)
PF07686
(V-set)
4 TRP A 111
TYR A 110
THR A 100
GLN A 104
None
1.33A 5tzoA-4pgjA:
undetectable
5tzoA-4pgjA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pju COHESIN SUBUNIT SA-2
DOUBLE-STRAND-BREAK
REPAIR PROTEIN RAD21
HOMOLOG


(Homo sapiens)
PF08514
(STAG)
no annotation
4 TRP B 381
THR A 626
THR A 586
GLN A 590
None
1.42A 5tzoA-4pjuB:
undetectable
5tzoA-4pjuB:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rep GAMMA-CAROTENE
DESATURASE


(Nonlabens
dokdonensis)
PF01593
(Amino_oxidase)
4 TRP A 309
THR A 410
ARG A 313
TRP A 368
None
GOL  A 502 ( 4.1A)
None
None
1.42A 5tzoA-4repA:
undetectable
5tzoA-4repA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk6 GLUCOSE-RESISTANCE
AMYLASE REGULATOR


(Weissella
paramesenteroides)
PF13377
(Peripla_BP_3)
4 THR A 224
TYR A 216
THR A 185
ARG A 195
None
None
None
GLC  A 401 (-2.6A)
1.33A 5tzoA-4rk6A:
undetectable
5tzoA-4rk6A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN


(Mycolicibacterium
fortuitum)
PF00722
(Glyco_hydro_16)
4 THR A 220
TYR A 219
THR A 203
ARG A 140
THR  A 220 ( 0.8A)
TYR  A 219 ( 1.3A)
THR  A 203 ( 0.8A)
ARG  A 140 ( 0.6A)
1.05A 5tzoA-4w65A:
5.6
5tzoA-4w65A:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6y NANOBODY NBFEDF9

(Lama glama)
PF07686
(V-set)
4 THR B  28
TYR B  29
THR B  53
ARG B  54
None
1.33A 5tzoA-4w6yB:
undetectable
5tzoA-4w6yB:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0v 2',5'-PHOSPHODIESTER
ASE 12


(Homo sapiens)
PF03372
(Exo_endo_phos)
4 THR A 236
TYR A 235
ARG A 233
TRP A 197
None
1.07A 5tzoA-4z0vA:
undetectable
5tzoA-4z0vA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE


(Geobacillus
stearothermophilus)
PF00232
(Glyco_hydro_1)
4 TRP A  15
THR A 473
ARG A 403
GLN A 407
None
1.26A 5tzoA-4zfmA:
undetectable
5tzoA-4zfmA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7m BETA-XYLOSIDASE

(Trichoderma
reesei)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like)
4 TRP A 280
THR A 274
GLN A 230
TRP A 763
None
ZN  A1909 ( 4.4A)
None
None
1.29A 5tzoA-5a7mA:
undetectable
5tzoA-5a7mA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
ALPHA SUBUNIT


(Candidatus
Kuenenia
stuttgartiensis)
no annotation 4 TRP A 458
TYR A 554
ARG A 490
GLN A 557
None
1.38A 5tzoA-5c2vA:
undetectable
5tzoA-5c2vA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cd6 TPR-DOMAIN
CONTAINING PROTEIN


(Parabacteroides
distasonis)
PF17128
(DUF5107)
4 TRP A 299
THR A 560
TYR A 561
THR A 564
None
1.16A 5tzoA-5cd6A:
undetectable
5tzoA-5cd6A:
14.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ej3 ENDO-1,4-BETA-XYLANA
SE B


(Streptomyces
lividans)
PF00457
(Glyco_hydro_11)
4 THR A 100
THR A 119
ARG A 121
GLN A 135
None
1.26A 5tzoA-5ej3A:
27.5
5tzoA-5ej3A:
49.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ej3 ENDO-1,4-BETA-XYLANA
SE B


(Streptomyces
lividans)
PF00457
(Glyco_hydro_11)
5 TYR A 117
THR A 119
ARG A 121
GLN A 135
TRP A 137
None
0.74A 5tzoA-5ej3A:
27.5
5tzoA-5ej3A:
49.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyy CENTROLOBIUM
TOMENTOSUM LECTIN


(Centrolobium
tomentosum)
PF00139
(Lectin_legB)
4 THR A 183
TYR A 177
THR A 176
GLN A  71
None
1.03A 5tzoA-5eyyA:
undetectable
5tzoA-5eyyA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw7 GLUCOSIDASE YGJK

(Escherichia
coli)
PF01204
(Trehalase)
4 TRP A 323
TRP A 744
THR A 666
TRP A 685
BGC  A1003 (-3.9A)
None
None
None
1.42A 5tzoA-5gw7A:
undetectable
5tzoA-5gw7A:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxf ACRYLYL-COA
REDUCTASE ACUI


(Ruegeria
pomeroyi)
PF00107
(ADH_zinc_N)
4 THR A 156
ARG A 231
GLN A 235
TRP A 217
None
1.22A 5tzoA-5gxfA:
undetectable
5tzoA-5gxfA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hi8 ANTENNA PROTEIN

(Prochlorococcus
phage P-HM1)
PF06206
(CpeT)
4 TYR A  41
THR A  43
ARG A  55
GLN A  57
None
None
None
ACT  A 202 (-3.8A)
1.24A 5tzoA-5hi8A:
undetectable
5tzoA-5hi8A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbk BETA-GLUCOSIDASE

(Trichoderma
harzianum)
PF00232
(Glyco_hydro_1)
4 THR A 370
TYR A 298
THR A 299
ARG A 341
None
GOL  A 501 (-4.1A)
None
None
1.22A 5tzoA-5jbkA:
undetectable
5tzoA-5jbkA:
18.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jrm ENDO-1,4-BETA-XYLANA
SE


(Fusarium
oxysporum)
PF00457
(Glyco_hydro_11)
4 TYR A 117
ARG A 121
GLN A 135
TRP A 137
None
0.71A 5tzoA-5jrmA:
27.6
5tzoA-5jrmA:
47.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kis RHS2

(Yersinia
entomophaga)
no annotation 4 TRP B 480
THR B 470
ARG B 657
GLN B 652
None
1.26A 5tzoA-5kisB:
undetectable
5tzoA-5kisB:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5njf METALLOPROTEASE PMBA

(Escherichia
coli)
PF01523
(PmbA_TldD)
4 THR B 290
THR B 325
ARG B 316
GLN B 326
None
1.06A 5tzoA-5njfB:
undetectable
5tzoA-5njfB:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae)
no annotation 4 THR B  25
TYR B  28
THR B  10
ARG B  11
None
1.42A 5tzoA-5swiB:
undetectable
5tzoA-5swiB:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u38 LECTIN

(Platypodium
elegans)
PF00139
(Lectin_legB)
4 THR A 183
TYR A 177
THR A 176
GLN A  71
None
1.35A 5tzoA-5u38A:
undetectable
5tzoA-5u38A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME


(uncultured
organism)
no annotation 4 THR A 116
TYR A 122
THR A 124
GLN A 126
None
1.38A 5tzoA-5wh8A:
undetectable
5tzoA-5wh8A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wut ULAM111

(Flavobacterium
sp.)
no annotation 4 THR A  70
TYR A  44
THR A  68
GLN A  66
None
1.42A 5tzoA-5wutA:
5.0
5tzoA-5wutA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3r PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1


(Mus musculus)
no annotation 4 TRP A1730
THR A1732
THR A1737
GLN A1789
None
0.91A 5tzoA-6b3rA:
undetectable
5tzoA-6b3rA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfu SPIKE PROTEIN

(Coronavirus
HKU15)
no annotation 4 THR A 444
TYR A 436
ARG A 292
GLN A 293
None
1.28A 5tzoA-6bfuA:
undetectable
5tzoA-6bfuA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpz PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,MOUSE
PIEZO1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1


(Mus musculus)
no annotation 4 TRP A1730
THR A1732
THR A1737
GLN A1789
None
1.11A 5tzoA-6bpzA:
undetectable
5tzoA-6bpzA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eks SIALIDASE

(Vibrio cholerae)
no annotation 4 TRP A 553
THR A 554
TYR A 394
GLN A 423
None
1.40A 5tzoA-6eksA:
4.7
5tzoA-6eksA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae)
no annotation 4 THR A 635
THR A 589
GLN A 573
TRP A 575
None
1.42A 5tzoA-6eojA:
undetectable
5tzoA-6eojA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9n CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 1


(Homo sapiens)
no annotation 4 TYR A 701
THR A 782
GLN A 798
TRP A 784
None
1.23A 5tzoA-6f9nA:
undetectable
5tzoA-6f9nA:
15.96